Cancer Research and Treatment

Case Report

Calcified Carcinoma of the Gallbladder with Calcified Nodal Metastasis Presenting as a Porcelain Gallbladder: A Case Report: Eun Joo Yun, Dae Young Yoon, Chul Soon Choi, Sang Hoon Bae, Young Lan Seo, Suk Ki Chang, Kyoung Ja Lim, Jung Hye Kwon, Mi Jung Kwon, Eun Sook Nam; Cancer Res Treat. 2011;43(1):71-74. Published online March 31, 2011; DOI: https://doi.org/10.4143/crt.2011.43.1.71

Porcelain gallbladder is regarded as a risk factor of gallbladder cancer. A porcelain gallbladder with calcified regional lymph nodes was found using computed tomography (CT) and magnetic resonance imaging (MRI) in a 43-year-old man who presented with nausea, vomiting, and abdominal pain. His cholecystectomy specimen showed diffuse wall thickening and contained small gallstones. Histological examination revealed diffuse infiltrative adenocarcinoma with extensive intratumoral calcification (calcified carcinoma). The majority of the calcified material was located within or replaced the tumor glands, and was not found in the stroma. A lymph node was totally replaced with a calcified metastatic adenocarcinoma. To the best of our knowledge, only one case of calcified lymph node metastasis from a calcified carcinoma of the gallbladder has been previously reported in the literature. We herein add a case of calcified carcinoma of the gallbladder with calcified lymph node metastasis, presenting as a porcelain gallbladder on CT and MRI.

Citations

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A porcelain gallbladder and a rapid tumor dissemination
Juan-Ramón Gómez-López, Beatriz De Andrés-Asenjo, Christian Ortega-Loubon
Annals of Medicine and Surgery.2014; 3(4): 119. CrossRef
Porcelain Gallbladder: A Benign Process or Concern for Malignancy?
Thomas Schnelldorfer
Journal of Gastrointestinal Surgery.2013; 17(6): 1161. CrossRef

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Original Article

Microcalcification Classifications on Mammography and Breast Cancer Incidences: Jeoung Won Bae, Jin Kim, Min Young Cho, Jae Bok Lee, Bum Hwan Koo; J Korean Cancer Assoc. 1999;31(2):275-281.

Abstract PDF: PURPOSE
Since needle localization biopsy was introduced, it is widely performed for nonpalpable microcalcified breast lesions, but there are many controversies in determining the disease characteristics and guidelines of the biopsy for microcalcifications detected mammographically in the absence of any palpable mass. This study was designed to detennine the breast cancers according to microcalcification types.
MATERIALS AND METHODS
We reviewed 91 patients, who underwent breast biopsies between January 1995 and June 1998 for only microcalcified lesions detected by mammography at the Department of Surgery, Korea University Hospitals. Microcalcifications were defined as calcifications less than 1.0 mm. The needle localization biopsy was performed only on patients who were found to have five or more microcalcifications. We classified the mictocalcifications into three types; casting type, crushed-stone-like type, and amorphous type.
RESULTS
The mean age was 49 years (25 82 years). Sixteen patients (17.6%) among the 91 patients were diagnosed with the breast cancer; four (22.2%) of 18 patients with casting type, eight (21.6%) of 37 patients with crushed-stone-like type, and four (11.1%) of 36 patients with amorphous type microcalcifications. Breast cancers were more prevalent in casting and crushed-stone-like types than in amorphous types. There was no difference in the size of microcalcifiations between benign and malignant lesions 13.11+-10.89 rnm vs 13.13+-9.51 mm.
CONCLUSIONS
The patients who have more than 5 microcalcifications clustered within 1 cm circle detected at mammographic evaluation, especially in case of casting or crushed-stone-like type, should be advised to have localization biopsy to detect early breast cancer.

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