Cancer Research and Treatment

Original Articles

Hematologic malignancy

Impact of T-Cell Engagers on COVID-19–Related Mortality in B-Cell Lymphoma Patients Receiving B-Cell Depleting Therapy: Chan Mi Lee, Pyoeng Gyun Choe, Chang Kyung Kang, Hyeon Jae Jo, Nam Joong Kim, Sung-Soo Yoon, Tae Min Kim, Wan Beom Park, Myoung-don Oh; Cancer Res Treat. 2024;56(1):324-333. Published online July 6, 2023; DOI: https://doi.org/10.4143/crt.2023.738

Abstract PDF Supplementary Material PubReader ePub

Purpose
B-cell depleting therapies, including T-cell engager (TCE), are increasingly used for patients with hematologic malignancies, including during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate the relationship between TCE therapy and COVID-19–related outcomes among patients with COVID-19 and B-cell lymphomas receiving B-cell depleting therapy.
Materials and Methods
This retrospective cohort study included patients with B-cell lymphoma, who were admitted to Seoul Natio-nal University Hospital with COVID-19 between September 2021 and February 2023, and received B-cell depleting therapy before COVID-19 diagnosis. Multivariable logistic regression was used to identify factors associated with severe to critical COVID-19 and COVID-19–related mortality.
Results
Of 54 patients with B-cell lymphomas and COVID-19 who received B-cell depleting therapy, 14 were treated with TCE (TCE group) and 40 with rituximab (RTX group). COVID-19–related mortality was higher in the TCE group than in the RTX group (57.1% vs. 12.5%, p=0.002). In multivariable analyses, TCE therapy (adjusted odds ratio [aOR], 7.08; 95% confidence interval [CI], 1.29 to 38.76; p=0.024) and older age (aOR, 1.06; 95% CI, 1.00 to 1.13; p=0.035) were associated with severe to critical COVID-19. TCE therapy (aOR, 8.98; 95% CI, 1.48 to 54.40; p=0.017), older age (aOR, 1.13; 95% CI, 1.02 to 1.26; p=0.022), and prior bendamustine therapy (aOR, 7.78; 95% CI, 1.17 to 51.65; p=0.034) were independent risk factors for COVID-19–related mortality.
Conclusion
B-cell lymphoma patients treated with TCE had significantly worse outcomes from COVID-19 than those treated with RTX. TCE therapy should be used with caution in B-cell lymphoma patients during the COVID-19 epidemic.

Citations

Citations to this article as recorded by

Long-Term Outcomes of COVID-19 and Risk Factors for Prolonged or Persistent COVID-19 in Lymphoma Patients: A Multicenter, Retrospective Cohort Study
Jung Ah Lee, Min Han, Sangmin Ahn, Yongseop Lee, Joon-Sup Yeom, Jun Yong Choi, Nam Su Ku, Su Jin Jeong, Jung Ho Kim, Jin Seok Kim, Haerim Chung, Hyunsoo Cho, Yu Ri Kim, Jin Young Ahn
Journal of Korean Medical Science.2024;[Epub] CrossRef
Features of the T-cell immune response in patients with hematological diseases after SARS-CoV-2 infection and vaccination
K. V. Zornikova, N. O. Ivanova, O. A. Aleshina, S. A. Sheetikov, V. D. Davydova, A. V. Bogolyubova
Russian journal of hematology and transfusiology.2024; 69(2): 200. CrossRef
Call for Balancing the Risks and Benefits of Immunotherapeutic Agents for Lymphoma during the COVID-19 Pandemic
Chan Mi Lee, Wan Beom Park
Infection & Chemotherapy.2024; 56(3): 406. CrossRef
Epcoritamab in relapsed/refractory large B-cell lymphoma: 2-year follow-up from the pivotal EPCORE NHL-1 trial
Catherine Thieblemont, Yasmin H. Karimi, Herve Ghesquieres, Chan Y. Cheah, Michael Roost Clausen, David Cunningham, Wojciech Jurczak, Young Rok Do, Robin Gasiorowski, David John Lewis, Tae Min Kim, Marjolein van der Poel, Michelle Limei Poon, Tatyana Feld
Leukemia.2024; 38(12): 2653. CrossRef

3,238 View
192 Download
3 Web of Science
4 Crossref

Breast cancer

Health-Seeking Behavior Returning to Normalcy Overcoming COVID-19 Threat in Breast Cancer: Eun-Gyeong Lee, Yireh Han, Dong-Eun Lee, Hyeong-Gon Moon, Hyoung Won Koh, Eun-Kyu Kim, So-Youn Jung; Cancer Res Treat. 2023;55(4):1222-1230. Published online April 3, 2023; DOI: https://doi.org/10.4143/crt.2023.364

Abstract PDF Supplementary Material PubReader ePub: Purpose
The coronavirus disease 2019 (COVID-19) outbreak has significantly impacted the diagnosis and treatment of breast cancer. Our study investigated the change in diagnosis and treatment of breast cancer with the progress of COVID-19 pandemic.
Materials and Methods
The study group comprised 6,514 recently diagnosed breast cancer patients between January 1, 2019, and February 28, 2021. The patients were divided into two groups: pre–COVID-19 period (3,182; January 2019 to December 2019) and COVID-19 pandemic period (3,332; January 2020 to February 2021). Clinicopathological information related to the first treatment after breast cancer diagnosis was retrospectively collected and analyzed in the two groups.
Results
Among the 6,514 breast cancer patients, 3,182 were in the pre–COVID-19 period and 3,332 were in the COVID-19 pandemic period. According to our evaluation, the least breast cancer diagnosis (21.8%) was seen in the first quarter of 2020. The diagnosis increased gradually except for the fourth quarter in 2020. While early-stage breast cancer was diagnosed 1,601 (48.1%) during the COVID-19 pandemic (p=0.001), the number of surgical treatments increased 4.6% (p < 0.001), and the treatment time was slightly shorter 2 days (p=0.001). The breast cancer subtype distribution was not statistically different between the pre–COVID-19 and COVID-19 period groups.
Conclusion
In the early stages of the pandemic, the number of breast cancer cases temporarily decreased; however, they stabilized soon, and no significant differences could be identified in the diagnosis and treatment when compared to the period before the pandemic.

2,763 View
164 Download

General

Immunogenicity and Safety of Vaccines against Coronavirus Disease in Actively Treated Patients with Solid Tumors: A Prospective Cohort Study: Yae Jee Baek, Youn-Jung Lee, So Ra Park, Kyoo Hyun Kim, Seung-Hoon Beom, Choong-kun Lee, Sang Joon Shin, Sun Young Rha, Sinyoung Kim, Kyoung Hwa Lee, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Minkyu Jung, Jin Young Ahn; Cancer Res Treat. 2023;55(3):746-757. Published online February 9, 2023; DOI: https://doi.org/10.4143/crt.2022.1541

Abstract PDF Supplementary Material PubReader ePub

Purpose
We aimed to assess the humoral response to and reactogenicity of coronavirus disease 2019 (COVID-19) vaccination according to the vaccine type and to analyze factors associated with immunogenicity in actively treated solid cancer patients (CPs).
Materials and Methods
Prospective cohorts of CPs, undergoing anticancer treatment, and healthcare workers (HCWs) were established. The participants had no history of previous COVID-19 and received either mRNA-based or adenovirus vector–based (AdV) vaccines as the primary series. Blood samples were collected before the first vaccination and after 2 weeks for each dose vaccination. Spike-specific binding antibodies (bAbs) in all participants and neutralizing antibodies (nAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wild-type, Delta, and Omicron variants in CPs were analyzed and presented as the geometric mean titer.
Results
Age-matched 20 HCWs and 118 CPs were included in the analysis. The bAb seroconversion rate and antibody concentrations after the first vaccination were significantly lower in CPs than in HCWs. After the third vaccination, antibody levels in CPs with a primary series of AdV were comparable to those in HCWs, but nAb titers against the Omicron variant did not quantitatively increase in CPs with AdV vaccine as the primary series. The incidence and severity of adverse reactions post-vaccination were similar between CPs and HCWs.
Conclusion
CPs displayed delayed humoral immune response after SARS-CoV-2 vaccination. The booster dose elicited comparable bAb concentrations between CPs and HCWs, regardless of the primary vaccine type. Neutralization against the Omicron variant was not robustly elicited following the booster dose in some CPs, implying the need for additional interventions to protect them from COVID-19.

Citations

Citations to this article as recorded by

Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study
Hong-Hong Liu, Yunbo Xie, Bao-Peng Yang, Huan-Yue Wen, Peng-Hui Yang, Jin-E Lu, Yan Liu, Xi Chen, Meng-Meng Qu, Yang Zhang, Wei-Guo Hong, Yong-Gang Li, Junliang Fu, Fu-Sheng Wang
Signal Transduction and Targeted Therapy.2024;[Epub] CrossRef
Immune response of COVID-19 vaccines in solid cancer patients: A meta-analysis
Tiantian Hua, Ru Fan, Yang Fan, Feng Chen
Human Vaccines & Immunotherapeutics.2024;[Epub] CrossRef
A Three-Dose mRNA COVID-19 Vaccine Regime Produces Both Suitable Immunogenicity and Satisfactory Efficacy in Patients with Solid Cancers
Urska Janzic, Urska Bidovec-Stojkovic, Peter Korosec, Katja Mohorcic, Loredana Mrak, Marina Caks, Maja Ravnik, Erik Skof, Matija Rijavec
Vaccines.2023; 11(6): 1017. CrossRef
Neutralizing Antibody Response following a Third Dose of the mRNA-1273 Vaccine among Cancer Patients
Christopher W. Dukes, Marine Potez, Jeffrey Lancet, Barbara J. Kuter, Junmin Whiting, Qianxing Mo, Brett Leav, Haixing Wang, Julie S. Vanas, Christopher L. Cubitt, Kimberly Isaacs-Soriano, Kayoko Kennedy, Julie Rathwell, Julian Diaz Cobo, Wesley O’Nan, Br
Vaccines.2023; 12(1): 13. CrossRef

4,489 View
209 Download
4 Web of Science
4 Crossref

Functional Impairments in the Mental Health, Depression and Anxiety Related to the Viral Epidemic, and Disruption in Healthcare Service Utilization among Cancer Patients in the COVID-19 Pandemic Era: Kyumin Kim, Harin Kim, Joohee Lee, Inn-Kyu Cho, Myung Hee Ahn, Ki Young Son, Jeong Eun Kim, Hee Jeong Kim, Sang Min Yoon, So Hee Kim, Moon Jung Kwon, Hwa Jung Kim, Su-Jin Koh, Seyoung Seo, Seockhoon Chung; Cancer Res Treat. 2022;54(3):671-679. Published online September 17, 2021; DOI: https://doi.org/10.4143/crt.2021.585

Abstract PDF PubReader ePub

Purpose
Literature is scarce regarding cancer care utilization during the massive outbreak of coronavirus disease 2019 (COVID-19) in the Republic of Korea. We investigated functional impairments in mental health and their relationships with depression, anxiety regarding the viral epidemic, and disruptions in healthcare service utilization among cancer patients in the COVID-19 pandemic era.
Materials and Methods
We used an online survey with questions related to the disturbances faced by patients with cancer in utilizing healthcare services in the pandemic era. Current mental health status was assessed using the Work and Social Adjustment Scale (WSAS), Stress and Anxiety to Viral Epidemics-6 (SAVE-6) scale, Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI), Brief Resilience Scale (BRS), Cancer-Related Dysfunctional Beliefs about Sleep Scale (C-DBS), and Fear of COVID-19 over Cancer (FCC).
Results
Among the 221 responders, 95 (43.0%) reported disruptions in healthcare service utilization during the COVID-19 pandemic. Logistic regression analysis revealed that functional impairment in the mental health of these patients was expected due to disruptions in healthcare service utilization, high levels of depression, anxiety regarding the viral epidemic, fear of COVID over cancer, and low resilience. Mediation analysis showed that patient resilience and cancer-related dysfunctional beliefs about sleep partially mediated the effects of viral anxiety on functional impairment.
Conclusion
In this pandemic era, patients with cancer experience depression, anxiety regarding the viral epidemic, and disruptions in healthcare service utilization, which may influence their functional impairments in mental health.

Citations

Citations to this article as recorded by

Prevalence of depressive symptoms and correlates among individuals who self-reported SARS-CoV-2 infection after optimizing the COVID-19 response in China
Liangjia Wei, Jiao Qin, Zhifeng Lin, Xinju Huang, Jinfeng He, Dee Yu, Fei Zhang, Sisi Li, Ping Cen, Mu Li, Tong Luo, Rongjing Zhang, Shanmei Zhong, Cai Qin, Zeyu Li, Yuan Yang, Huiqi Pan, Mengdi Zhao, Xiaoqiong Wu, Junjun Jiang, Hao Liang, Li Ye, Bingyu L
Frontiers in Public Health.2024;[Epub] CrossRef
Evaluation of mental health of students in healthcare education programs at Qatar University
Ola Hayk, Abdulla Mansoor, Shahd Al-Najdi, Alaa Daud, Rula Shami, Najah Al-Hashimi, Kamran Ali
MedEdPublish.2024; 14: 37. CrossRef
Inpatient Hospice Care in Korea during the COVID-19 Pandemic: A Preliminary Study
Youn Seon Choi, Sun Wook Hwang, In Cheol Hwang
Journal of Hospice and Palliative Care.2024; 27(2): 82. CrossRef
The COVID-19 pandemic experience for patients with central nervous system tumors: Differences in patient-reported outcomes and practice recommendations
Amanda L King, Kayla N Roche, Elizabeth Vera, Valentina Pillai, Lily Polskin, Alvina A Acquaye-Mallory, Lisa Boris, Eric Burton, Anna Choi, Ewa Grajkowska, Heather E Leeper, Marissa Panzer, Marta Penas-Prado, Jennifer Reyes, Solmaz Sahebjam, Brett J Theel
Neuro-Oncology Practice.2024;[Epub] CrossRef
Risk factors for heightened COVID‐19‐Related anxiety among breast cancer patients
Yash B. Shah, Stephanie Kjelstrom, Diana Martinez, Adam Leitenberger, Donna‐Marie Manasseh, Melissa Bollmann‐Jenkins, Ann Partridge, Virginia Kaklamani, Rowen Chlebowski, Sharon Larson, Marisa Weiss
Cancer Medicine.2023; 12(3): 3577. CrossRef
Discrepancy between desired time in bed and desired total sleep time in patients with cancer: The DBST index and its relationship with insomnia severity and sleep onset latency
Eulah Cho, Jaeeun Song, Joohee Lee, Inn-Kyu Cho, Dongin Lee, Hayun Choi, Harin Kim, Seockhoon Chung
Frontiers in Psychiatry.2023;[Epub] CrossRef
Health-related quality of life and depressive symptoms of patients with chronic diseases and the general population before and during the COVID-19 pandemic in Korea
Yeeun Park, Kyong Park
Frontiers in Psychology.2023;[Epub] CrossRef
A study of COVID anxiety, spiritual well-being and resilience levels in patients with cancer undergoing chemotherapy during the COVID-19 pandemic: a cross-sectional study in the south of Iran
Zahra Khiyali, Zeinab Naderi, Mohammadkazem Vakil, Hajar Ghasemi, Azizallah Dehghan, Mostafa Bijani
BMC Psychology.2023;[Epub] CrossRef
Does Viral Anxiety Influence the Insomnia Severity Among Patients With Insomnia Disorder During COVID-19 Pandemic?
Jana Sleiman, Eulah Cho, Dongin Lee, Inn-Kyu Cho, Seockhoon Chung, Omer Faruk Uygur
Sleep Medicine Research.2023; 14(1): 25. CrossRef
Associations of psychological status and ultrasonic characteristics of thyroid nodules in adults during the COVID-19 pandemic
Zhengwu Lei, Zhongxiang He, Ying Mei, Xiaoya Qi, Pingping Yu, Guoqiong Xu, Hongfeng Cheng, Ruixue Bai, Jing Deng
Frontiers in Psychology.2023;[Epub] CrossRef
The Impact of COVID-19 on Psychiatric Health in the Korean Population
Sheng-Min Wang, Sung-Hwan Kim, Won-Seok Choi, Hyun Kook Lim, Young Sup Woo, Chi-Un Pae, Won-Myong Bahk
Clinical Psychopharmacology and Neuroscience.2023; 21(3): 410. CrossRef
Adherence to Physical Distancing and Health Beliefs About COVID-19 Among Patients With Cancer
Sajida Fawaz Hammoudi, Oli Ahmed, Hoyoung An, Youjin Hong, Myung Hee Ahn, Seockhoon Chung
Journal of Korean Medical Science.2023;[Epub] CrossRef
Catastrophizing Maladaptive Coping Affects the Association Between Viral Anxiety and Fear of Progression in Cancer Patients During COVID-19 Pandemic
Hyuk Joo Lee, Cheolkyung Sin, Hyeyeong Kim, Hyeon-Su Im, Jae-Cheol Jo, Yoo Jin Lee, Youjin Kim, Junseok Ahn, Soyoung Yoo, Su-Jin Koh, Seockhoon Chung
Psychiatry Investigation.2023; 20(12): 1204. CrossRef
The role of social support and resilience in the mental health impact of the COVID-19 pandemic among healthcare workers in Spain
Esther Ortiz-Calvo, Gonzalo Martínez-Alés, Roberto Mediavilla, Elisabeth González-Gómez, Eduardo Fernández-Jiménez, María-Fe Bravo-Ortiz, Berta Moreno-Küstner
Journal of Psychiatric Research.2022; 148: 181. CrossRef
The Validation Study of the Stress and Anxiety to Viral Epidemics−6 Scale Among Patients With Cancer in the COVID-19 Pandemic
Hyeyeong Kim, Harin Kim, Hyuk Joo Lee, Eulah Cho, Su-Jin Koh, Oli Ahmed, Seockhoon Chung
Frontiers in Psychiatry.2022;[Epub] CrossRef
Resilience, Social Support, and Anxious Preoccupation in Patients with Advanced Cancer during COVID-19 Pandemic
Veronica Velasco-Durantez, Paula Jimenez-Fonseca, Carla M. Martín Abreu, Ismael Ghanem, Manuel González Moya, Elena Asensio, María J. Corral, Adan Rodriguez-Gonzalez, Mireia Gil-Raga, Alberto Carmona-Bayonas, Caterina Calderon
Cancer Investigation.2022; 40(6): 475. CrossRef
Mental Health in Postoperative Thyroid Patients During the COVID-19 Pandemic
Shijie Yang, Xiequn Xu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Effect of Cancer-Related Dysfunctional Beliefs About Sleep on Fear of Cancer Progression in the Coronavirus Pandemic
Harin Kim, Inn-Kyu Cho, Dongin Lee, Kyumin Kim, Joohee Lee, Eulah Cho, C. Hyung Keun Park, Seockhoon Chung
Journal of Korean Medical Science.2022;[Epub] CrossRef
Insomnia Mediate the Influence of Reassurance-Seeking Behavior and Viral Anxiety on Preoccupation With COVID-19 Among the General Population
Eulah Cho, Dongin Lee, Inn-Kyu Cho, Joohee Lee, Junseok Ahn, Young Rong Bang
Sleep Medicine Research.2022; 13(2): 68. CrossRef
Reliability and Validity of Dysfunctional Beliefs About Sleep-2 (DBS-2), an Ultra-brief Rating Scale for Assessing Dysfunctional Thoughts About Sleep
Kyumin Kim, Seockhoon Chung, Eulah Cho, Jung Mun Choi, Dongin Lee, Inn-Kyu Cho
Sleep Medicine Research.2022; 13(3): 165. CrossRef

9,454 View
277 Download
18 Web of Science
20 Crossref

Special Article

Guidelines for Cancer Care during the COVID-19 Pandemic in South Korea: Jii Bum Lee, Minkyu Jung, June Hyuk Kim, Bo Hyun Kim, Yeol Kim, Young Seok Kim, Byung Chang Kim, Jin Kim, Sung Ho Moon, Keon-Uk Park, Meerim Park, Hyeon Jin Park, Sung Hoon Sim, Hong Man Yoon, Soo Jung Lee, Eunyoung Lee, June Young Chun, Youn Kyung Chung, So-Youn Jung, Jinsoo Chung, Eun Sook Lee, Hyun Cheol Chung, Tak Yun, Sun Young Rha; Cancer Res Treat. 2021;53(2):323-329. Published online March 15, 2021; DOI: https://doi.org/10.4143/crt.2020.1256

Abstract PDF PubReader ePub

At the end of 2019, the cause of pneumonia outbreaks in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In February 2020, the World Health Organization named the disease cause by SARS-CoV-2 as coronavirus disease 2019 (COVID-19). In response to the pandemic, the Korean Cancer Association formed the COVID-19 task force to develop practice guidelines. This special article introduces the clinical practice guidelines for cancer patients which will help oncologists best manage cancer patients during the COVID-19 pandemic.

Citations

Citations to this article as recorded by

Preoperative COVID-19 and Postoperative Mortality in Cancer Surgery: A South Korean Nationwide Study
Jae-Woo Ju, Soo-Hyuk Yoon, Tak Kyu Oh, Ho-Jin Lee
Annals of Surgical Oncology.2024; 31(10): 6394. CrossRef
Impact of the COVID-19 Pandemic on Esophagogastroduodenoscopy and Gastric Cancer Claims in South Korea: A Nationwide, Population-Based Study
Min Ah Suh, Su Bee Park, Min Seob Kwak, Jin Young Yoon, Jae Myung Cha
Yonsei Medical Journal.2023; 64(9): 549. CrossRef
The elderly population are more vulnerable for the management of colorectal cancer during the COVID-19 pandemic: a nationwide, population-based study
Hong Sun Kang, Seung Hoon Jeon, Su Bee Park, Jin Young Youn, Min Seob Kwak, Jae Myung Cha
Intestinal Research.2023; 21(4): 500. CrossRef
Impact of Coronavirus Disease 2019 on Gastric Cancer Diagnosis and Stage: A Single-Institute Study in South Korea
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim,
Journal of Gastric Cancer.2023; 23(4): 574. CrossRef
Health-Seeking Behavior Returning to Normalcy Overcoming COVID-19 Threat in Breast Cancer
Eun-Gyeong Lee, Yireh Han, Dong-Eun Lee, Hyeong-Gon Moon, Hyoung Won Koh, Eun-Kyu Kim, So-Youn Jung
Cancer Research and Treatment.2023; 55(4): 1222. CrossRef
Adherence to Physical Distancing and Health Beliefs About COVID-19 Among Patients With Cancer
Sajida Fawaz Hammoudi, Oli Ahmed, Hoyoung An, Youjin Hong, Myung Hee Ahn, Seockhoon Chung
Journal of Korean Medical Science.2023;[Epub] CrossRef
To overcome medical gap in screening and surveillance of colorectal cancer during the COVID-19 pandemic
Yoo Min Han
Intestinal Research.2023; 21(4): 418. CrossRef
COVID-19 pandemic: a new cause of unplanned interruption of radiotherapy in breast cancer patients
Shiho Lee, Jaesung Heo
Medical Oncology.2022;[Epub] CrossRef
Impact of the COVID-19 Pandemic on Breast Cancer Management in Portugal: A Cross-Sectional Survey-Based Study of Medical Oncologists
Diogo Alpuim Costa, José Guilherme Gonçalves Nobre, João Paulo Fernandes, Marta Vaz Batista, Ana Simas, Carolina Sales, Helena Gouveia, Leonor Abreu Ribeiro, Andreia Coelho, Margarida Brito, Mariana Inácio, André Cruz, Mónica Mariano, Joana Savva-Bordalo,
Oncology and Therapy.2022; 10(1): 225. CrossRef
Organisation of cancer care in troubling times: A scoping review of expert guidelines and their implementation during the COVID-19 pandemic
Brenda Bogaert, Victoria Buisson, Zizis Kozlakidis, Pierre Saintigny
Critical Reviews in Oncology/Hematology.2022; 173: 103656. CrossRef
Surgical safety in the COVID-19 era: present and future considerations
Young Il Kim, In Ja Park
Annals of Surgical Treatment and Research.2022; 102(6): 295. CrossRef
Effect of Cancer-Related Dysfunctional Beliefs About Sleep on Fear of Cancer Progression in the Coronavirus Pandemic
Harin Kim, Inn-Kyu Cho, Dongin Lee, Kyumin Kim, Joohee Lee, Eulah Cho, C. Hyung Keun Park, Seockhoon Chung
Journal of Korean Medical Science.2022;[Epub] CrossRef
Impact of the COVID-19 Pandemic on Gastric Cancer Screening in South Korea: Results From the Korean National Cancer Screening Survey (2017–2021)
Kyeongmin Lee, Mina Suh, Jae Kwan Jun, Kui Son Choi
Journal of Gastric Cancer.2022; 22(4): 297. CrossRef
Changes in cancer screening before and during COVID‐19: findings from the Korean National Cancer Screening Survey 2019 and 2020
Thao Thi Kim Trinh, Yun Yeong Lee, Mina Suh, Jae Kwan Jun, Kui Son Choi
Epidemiology and Health.2022; 44: e2022051. CrossRef
Treatment decision for cancer patients with fever during the coronavirus disease 2019 (COVID-19) pandemic
In Hee Lee, Sung Ae Koh, Soo Jung Lee, Sun Ah Lee, Yoon Young Cho, Ji Yeon Lee, Jin Young Kim
Yeungnam University Journal of Medicine.2021; 38(4): 344. CrossRef

9,120 View
246 Download
14 Web of Science
15 Crossref

Original Articles

General

Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19: Tung Hoang, Trung Quang Nguyen, Tho Thi Anh Tran; Cancer Res Treat. 2021;53(3):650-656. Published online December 29, 2020; DOI: https://doi.org/10.4143/crt.2020.950

Abstract PDF Supplementary Material PubReader ePub

Purpose
Coronavirus disease 2019 (COVID-19) pandemic has spread worldwide rapidly and patients with cancer have been considered as a vulnerable group for this infection. This study aimed to examine the expressions of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in tumor tissues of six common cancer types.
Materials and Methods
The expression levels of ACE2 and TMPRSS2 in tumors and control samples were obtained from online databases. Survival prognosis and biological functions of these genes were investigated for each tumor type.
Results
There was the overexpression of ACE2 in colon and stomach adenocarcinomas compared to controls, meanwhile colon and prostate adenocarcinomas showed a significantly higher expression of TMPRSS2. Additionally, survival prognosis analysis has demonstrated that upregulation of ACE2 in liver hepatocellular carcinoma was associated with higher overall survival (hazard ratio, 0.65; p=0.016) and disease-free survival (hazard ratio, 0.66; p=0.007), while overexpression of TMPRSS2 was associated with a 26% reduced risk of death in lung adenocarcinoma (p=0.047) but 50% increased risk of death in breast invasive carcinoma (p=0.015).
Conclusion
There is a need to take extra precautions for COVID-19 in patients with colorectal cancer, stomach cancer, and lung cancer. Further information on other types of cancer at different stages should be investigated.

Citations

Citations to this article as recorded by

In vitro analysis suggests that SARS-CoV-2 infection differentially modulates cancer-like phenotypes and cytokine expression in colorectal and prostate cancer cells
Alberta Serwaa, Fatima Oyawoye, Irene Amoakoh Owusu, Daniel Dosoo, Aaron Adom Manu, Augustine Kojo Sobo, Kwadwo Fosu, Charles Ochieng Olwal, Peter Kojo Quashie, Anastasia Rosebud Aikins
Scientific Reports.2024;[Epub] CrossRef
Impacts of COVID-19 in Breast Cancer: From Molecular Mechanism to the Treatment Approach
Maria Carolina Stipp, Claudia Rita Corso, Alexandra Acco
Current Pharmaceutical Biotechnology.2023; 24(2): 238. CrossRef
A Multigene-Panel Study Identifies Single Nucleotide Polymorphisms Associated with Prostate Cancer Risk
Maria Antonietta Manca, Fabio Scarpa, Davide Cossu, Elena Rita Simula, Daria Sanna, Stefano Ruberto, Marta Noli, Hajra Ashraf, Tatiana Solinas, Massimo Madonia, Roberto Cusano, Leonardo A. Sechi
International Journal of Molecular Sciences.2023; 24(8): 7594. CrossRef
Covid-19 And Cancer: Insights Into Their Association And Influence On Genetic And Epigenetic Landscape
Mrinal K Ghosh, Sunny Kumar, Kirat K Ganguly, Pratyay Ghosh, Shaheda Tabassum, Bhaskar Basu, Malini Basu
Epigenomics.2023; 15(4): 227. CrossRef
Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma
Xiao Liang, Yali Chen, Yuchao Fan
Environmental Science and Pollution Research.2022; 29(15): 22012. CrossRef
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19
Li Liu, Ju‐Fang Qin, Man‐Zhen Zuo, Quan Zhou
Journal of Cellular and Molecular Medicine.2022; 26(3): 709. CrossRef
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2–Related Genes in Kidney Renal Clear Cell Carcinoma
Yongbiao Huang, Sheng Chen, Lingyan Xiao, Wan Qin, Long Li, Yali Wang, Li Ma, Xianglin Yuan
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef
Potential therapeutic strategies for quercetin targeting critical pathological mechanisms associated with colon adenocarcinoma and COVID-19
Xiushen Li, Weizheng Liang, Chengwei Yu, Qingxue Meng, Weiwen Zhang, Xueliang Wu, Jun Xue, Shoulong Deng, Hao Wang
Frontiers in Pharmacology.2022;[Epub] CrossRef
Assessing the Vulnerability of Cancer Patients for COVID-19
Saloni Bhatia, Padmini Gokhale, Teesta Katte, Shreeshanthi Acharya, Avinash Arvind Rasalkar, Soumya Vidapanakal, Ram Manas, Sampath Chinnam, Prathibha Narayanan, Ashok Kumar Shettihalli, Vijayakumar Kadappa, Divijendra Natha Reddy Sirigiri
ACS Omega.2022; 7(40): 35735. CrossRef
Biological effects of COVID-19 on lung cancer: Can we drive our decisions
Beatrice Aramini, Valentina Masciale, Anna Valeria Samarelli, Roberto Tonelli, Stefania Cerri, Enrico Clini, Franco Stella, Massimo Dominici
Frontiers in Oncology.2022;[Epub] CrossRef
COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario
Shomoita Sayed
Cancer Treatment and Research Communications.2021; 28: 100425. CrossRef
Neuropilin-1: A feasible link between liver pathologies and COVID-19
Aitor Benedicto, Iñigo García-Kamiruaga, Beatriz Arteta
World Journal of Gastroenterology.2021; 27(24): 3516. CrossRef

8,702 View
214 Download
12 Web of Science
12 Crossref

Lung Cancer

Risk of Coronavirus Disease 2019 Occurrence, Severe Presentation, and Mortality in Patients with Lung Cancer: Bumhee Yang, Hayoung Choi, Sun-Kyung Lee, Sung Jun Chung, Yoomi Yeo, Yoon Mi Shin, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Yun Su Sim, Ho Joo Yoon, Jang Won Sohn, Hyun Lee, Sang-Heon Kim; Cancer Res Treat. 2021;53(3):678-684. Published online December 28, 2020; DOI: https://doi.org/10.4143/crt.2020.1242

Abstract PDF PubReader ePub

Purpose
This study aimed to analyze whether patients with lung cancer have a higher susceptibility of coronavirus disease 2019 (COVID-19), severe presentation, and higher mortality than those without lung cancer.
Materials and Methods
A nationwide cohort of confirmed COVID-19 (n=8,070) between January 1, 2020, and May 30, 2020, and a 1:15 age-, sex-, and residence-matched cohort (n=121,050) were constructed. A nested case-control study was performed to compare the proportion of patients with lung cancer between the COVID-19 cohort and the matched cohort.
Results
The proportion of patients with lung cancer was significantly higher in the COVID-19 cohort (0.5% [37/8,070]) than in the matched cohort (0.3% [325/121,050]) (p=0.002). The adjusted odds ratio [OR] of having lung cancer was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR, 1.51; 95% confidence interval [CI], 1.05 to 2.10). Among patients in the COVID-19 cohort, compared to patients without lung cancer, those with lung cancer were more likely to have severe COVID-19 (54.1% vs. 13.2%, p < 0.001), including mortality (18.9% vs. 2.8%, p < 0.001). The adjusted OR for the occurrence of severe COVID-19 in patients with lung cancer relative to those without lung cancer was 2.24 (95% CI, 1.08 to 4.74).
Conclusion
The risk of COVID-19 occurrence and severe presentation, including mortality, may be higher in patients with lung cancer than in those without lung cancer.

Citations

Citations to this article as recorded by

Increased Risk of New-Onset Asthma After COVID-19: A Nationwide Population-Based Cohort Study
Bo-Guen Kim, Hyun Lee, Sang Woo Yeom, Cho Yun Jeong, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Jong Seung Kim, Sang-Heon Kim
The Journal of Allergy and Clinical Immunology: In Practice.2024; 12(1): 120. CrossRef
Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: a nationwide population-based cohort study
Bo-Guen Kim, Hyun Lee, Cho Yun Jeong, Sang Woo Yeom, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Jong Seung Kim, Sang-Heon Kim
Frontiers in Public Health.2024;[Epub] CrossRef
Microwave ablation for high-risk pulmonary nodules in patients infected with the Omicron variant of Sars-Cov-2 within 3 months: a retrospective analysis of safety and efficacy
Yuxian Chen, Yang Li, Hong Meng, Chunhai Li, Fanlei Kong
Frontiers in Oncology.2024;[Epub] CrossRef
A year of experience with COVID‐19 in patients with cancer: A nationwide study
Mina Khosravifar, Sogol Koolaji, Negar Rezaei, Ali Ghanbari, Seyedeh Melika Hashemi, Erfan Ghasemi, Ali Bitaraf, Ozra Tabatabaei‐Malazy, Nazila Rezaei, Sahar Mohammadi Fateh, Arezou Dilmaghani‐Marand, Rosa Haghshenas, Ameneh Kazemi, Erfan Pakatchian, Farz
Cancer Reports.2023;[Epub] CrossRef
Risk factors for mortality among lung cancer patients with covid-19 infection: A systematic review and meta-analysis
Mingyue Wu, Siru Liu, Changyu Wang, Yuxuan Wu, Jialin Liu, Yoon-Seok Chung
PLOS ONE.2023; 18(9): e0291178. CrossRef
International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical Trials
Matthew P. Smeltzer, Giorgio V. Scagliotti, Heather A. Wakelee, Tetsuya Mitsudomi, Upal Basu Roy, Russell C. Clark, Renee Arndt, Clayton D. Pruett, Karen L. Kelly, Peter Ujhazy, Melissa L. Johnson, Yesim Eralp, Carlos H. Barrios, Fabrice Barlesi, Fred R.
Journal of Thoracic Oncology.2022; 17(5): 651. CrossRef
Conceptual Framework for Cancer Care During a Pandemic Incorporating Evidence From the COVID-19 Pandemic
Vivienne Milch, Anne E. Nelson, Melissa Austen, Debra Hector, Scott Turnbull, Rahul Sathiaraj, Carolyn Der Vartanian, Rhona Wang, Cleola Anderiesz, Dorothy Keefe
JCO Global Oncology.2022;[Epub] CrossRef
COVID-19 and Lung Cancer Survival: An Updated Systematic Review and Meta-Analysis
Simone Oldani, Fausto Petrelli, Giuseppina Dognini, Karen Borgonovo, Maria Chiara Parati, Mara Ghilardi, Lorenzo Dottorini, Mary Cabiddu, Andrea Luciani
Cancers.2022; 14(22): 5706. CrossRef
Interstitial lung disease increases susceptibility to and severity of COVID-19
Hyun Lee, Hayoung Choi, Bumhee Yang, Sun-Kyung Lee, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
European Respiratory Journal.2021; 58(6): 2004125. CrossRef
Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis
Marco Tagliamento, Elisa Agostinetto, Marco Bruzzone, Marcello Ceppi, Kamal S. Saini, Evandro de Azambuja, Kevin Punie, C. Benedikt Westphalen, Gilberto Morgan, Paolo Pronzato, Lucia Del Mastro, Francesca Poggio, Matteo Lambertini
Critical Reviews in Oncology/Hematology.2021; 163: 103365. CrossRef
Characteristics and outcomes of the Korean patients with coronavirus disease 2019; analyses of the national database
Sang-Heon Kim
Allergy, Asthma & Respiratory Disease.2021; 9(3): 113. CrossRef

8,192 View
195 Download
10 Web of Science
11 Crossref

First
Prev
Page of 1
Next
Last

Search