Cancer Research and Treatment

Original Article

Displacement of Surgical Clips in Patients with Human Acellular Dermal Matrix in the Excision Cavity during Whole Breast Irradiation Following Breast-Conserving Surgery: Wonguen Jung, Kyubo Kim, Nam Sun Paik; Cancer Res Treat. 2020;52(2):388-395. Published online August 13, 2019; DOI: https://doi.org/10.4143/crt.2019.213

Purpose
The purpose of this study was to investigate the displacement of surgical clips in the excision cavity during whole breast irradiation following breast-conserving surgery (BCS) with or without acellular dermal matrix (ADM) insertion, and to analyze clinicopathologic factors associated with the displacement of surgical clips.
Materials and Methods
From 2016 to 2017, 100 consecutive breast cancer patients who underwent BCS with the placement of surgical clips (superior, inferior, medial, lateral, and deep sides) in the tumor bed were included in this study. All patients took first planning computed tomography (CT) scan (CT 1) before whole breast irradiation and second CT scan (CT 2) before boost irradiation. Between two sets of planning CT, the displacement of surgical clips was calculated from the ΔX (lateral–medial), ΔY (anterior–posterior), ΔZ (superior–inferior), and three-dimensional (3D) directions. Patients were divided into two groups according to the breast volume replacement with ADM: group A with ADM and group B without ADM.
Results
The means and 1 standard deviations of 3D displacement for superior, inferior, medial, lateral and deep clips were 5.2±2.9, 5.2±3.2, 5.6±4.5, 5.6±4.3, and 4.9±4.9 mm in entire cohort (n=100); 5.6±2.6, 6.0±3.5, 6.7±5.8, 6.7±5.7, and 6.1±7.4 mm in group A (n=38); 4.9±3.1, 4.8±3.0, 5.0±3.5, 5.0±2.9, and 4.3±2.8 mm in group B (n=62), respectively. The 3D displacements of group A were longer than those of group B, but only significant difference was observed in lateral clip (p=0.047).
Conclusion
This study demonstrated displacement of surgical clips during whole breast irradiation in patients with ADM insertion. For patients who had breast volume replacement using ADM, adaptive boost planning should be considered.

Citations

Citations to this article as recorded by

Interobserver variability of clinical target volume delineation in patients undergoing breast-conserving surgery without surgical clips: a pilot study on preoperative magnetic resonance simulation
Shuning Jiao, Yiqing Wang, Jiabin Ma, Jing Shen, Xi-Qian Zhang, Bing Zhou, Xiansong Sun, Haoran Xu, Xia Liu, Ke Hu, Fuquan Zhang, Xiaorong Hou, Jie Qiu
BMC Cancer.2024;[Epub] CrossRef
What Should We Know in Postoperative Surveillance Imaging After Oncoplastic Breast-Conserving Surgery with Pellet-Type Acellular Dermal Matrix?
Yeong Yi An, Hyejung Hwang, Young Jin Suh
Academic Radiology.2023; 30: S16. CrossRef
Imaging surveillance for the detection of ipsilateral local tumor recurrence in patients who underwent oncoplastic breast-conserving surgery with acellular dermal matrix: abbreviated MRI versus conventional mammography and ultrasonography
Mi Young Kim, Young Jin Suh, Yeong Yi An
World Journal of Surgical Oncology.2021;[Epub] CrossRef

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Review Article

RNA Regulation in Neurologic Disease and Cancer: Robert B. Darnell; Cancer Res Treat. 2010;42(3):125-129. Published online September 30, 2010; DOI: https://doi.org/10.4143/crt.2010.42.3.125

Abstract PDF PubReader ePub

The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tumor cells. Efforts to gain insight into their function has led to the development of new methods and strategies to understand RNA protein regulation in living tissues.

Citations

Citations to this article as recorded by

Identifying the mitochondrial ribosomal protein MRPL13 as an oncogenic RBP that promotes proliferation, migration, and anti-apoptotic effects in esophageal cancer cells
Yaxi Song, Hui Wang, Shiyao Li, Weili Tao, Chunqing Li, Bin Wang, Caifeng Gong
Heliyon.2024; : e39546. CrossRef
LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
Xiaoli Long, Xunhua Liu, Ting Deng, Jianxiong Chen, Jiawen Lan, Sijing Zhang, Miao Zhou, Dan Guo, Jun Zhou
Journal of Experimental & Clinical Cancer Research.2023;[Epub] CrossRef
Effect and mechanism of circRNAs in tumor angiogenesis and clinical application
Luyang Zhao, Yuying Guo, Yaxin Guo, Xiang Ji, Dandan Fan, Chen Chen, Weitang Yuan, Zhenqiang Sun, Zhenyu Ji
International Journal of Cancer.2022; 150(8): 1223. CrossRef
Widespread autogenous mRNA–protein interactions detected by CLIP-seq
Thomas H Kapral, Fiona Farnhammer, Weihao Zhao, Zhi J Lu, Bojan Zagrovic
Nucleic Acids Research.2022; 50(17): 9984. CrossRef
Computational tools to study RNA-protein complexes
Sneha Bheemireddy, Sankaran Sandhya, Narayanaswamy Srinivasan, Ramanathan Sowdhamini
Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
RNA Regulators in Leukemia and Lymphoma
Camila Prieto, Michael G. Kharas
Cold Spring Harbor Perspectives in Medicine.2020; 10(5): a034967. CrossRef
Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers
Kiyoshi Masuda, Yuki Kuwano
WIREs RNA.2019;[Epub] CrossRef
MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change
Qianru He, Lini Zhao, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Heng Cai, Zhen Li, Yixue Xue
Journal of Experimental & Clinical Cancer Research.2019;[Epub] CrossRef
KHDRBS3 regulates the permeability of blood–tumor barrier via cDENND4C/miR-577 axis
Peiqi Wu, Yang Gao, Shuyuan Shen, Yixue Xue, Xiaobai Liu, Xuelei Ruan, Lianqi Shao, Yunhui Liu, Ping Wang
Cell Death & Disease.2019;[Epub] CrossRef
IDH1 fine-tunes cap-dependent translation initiation
Lichao Liu, J Yuyang Lu, Fajin Li, Xudong Xing, Tong Li, Xuerui Yang, Xiaohua Shen, Zefeng Wang
Journal of Molecular Cell Biology.2019; 11(10): 816. CrossRef
Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer
Samantha Moore, Aino I Järvelin, Ilan Davis, Gareth L Bond, Alfredo Castello
Current Opinion in Genetics & Development.2018; 48: 112. CrossRef
Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer
Zhi Shang, Liqiang Qian, Sha Liu, Xiaomin Niu, Zhi Qiao, Yan Sun, Yan Zhang, Liu-Yin Fan, Xin Guan, Cheng-Xi Cao, Hua Xiao
ACS Applied Materials & Interfaces.2018; 10(21): 17756. CrossRef
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
Andrew T. Ludlow, Mandy Sze Wong, Jerome D. Robin, Kimberly Batten, Laura Yuan, Tsung-Po Lai, Nicole Dahlson, Lu Zhang, Ilgen Mender, Enzo Tedone, Mohammed E. Sayed, Woodring E. Wright, Jerry W. Shay
Nature Communications.2018;[Epub] CrossRef
Identification and Analysis of Key Residues in Protein–RNA Complexes
A. Kulandaisamy, Ambuj Srivastava, Pradeep Kumar, R. Nagarajan, S. Binny Priya, M. Michael Gromiha
IEEE/ACM Transactions on Computational Biology and Bioinformatics.2018; 15(5): 1436. CrossRef
RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment
Suntaek Hong
Journal of Cancer Prevention.2017; 22(4): 203. CrossRef
The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions
Benedikt M. Beckmann, Alfredo Castello, Jan Medenbach
Pflügers Archiv - European Journal of Physiology.2016; 468(6): 1029. CrossRef
NOVA2-mediated RNA regulation is required for axonal pathfinding during development
Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, Robert B Darnell
eLife.2016;[Epub] CrossRef
Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases
Magdalena Jazurek, Adam Ciesiolka, Julia Starega-Roslan, Katarzyna Bilinska, Wlodzimierz J. Krzyzosiak
Nucleic Acids Research.2016; : gkw803. CrossRef
UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis
Laurence Wurth, Panagiotis Papasaikas, David Olmeda, Nadine Bley, Guadalupe T. Calvo, Santiago Guerrero, Daniela Cerezo-Wallis, Javier Martinez-Useros, María García-Fernández, Stefan Hüttelmaier, Maria S. Soengas, Fátima Gebauer
Cancer Cell.2016; 30(5): 694. CrossRef
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma
Junichi Hamada, Katsutoshi Shoda, Kiyoshi Masuda, Yuji Fujita, Takuya Naruto, Tomohiro Kohmoto, Yuko Miyakami, Miki Watanabe, Yasusei Kudo, Hitoshi Fujiwara, Daisuke Ichikawa, Eigo Otsuji, Issei Imoto
Oncotarget.2016; 7(13): 17111. CrossRef
RNA-binding proteins, multifaceted translational regulators in cancer
Laurence Wurth, Fátima Gebauer
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2015; 1849(7): 881. CrossRef
RNA-binding proteins in neurological diseases
HuaLin Zhou, Marie Mangelsdorf, JiangHong Liu, Li Zhu, Jane Y Wu
Science China Life Sciences.2014; 57(4): 432. CrossRef
A versatile assay for RNA-binding proteins in living cells
Claudia Strein, Anne-Marie Alleaume, Ulrich Rothbauer, Matthias W. Hentze, Alfredo Castello
RNA.2014; 20(5): 721. CrossRef
RNA-binding proteins in Mendelian disease
Alfredo Castello, Bernd Fischer, Matthias W. Hentze, Thomas Preiss
Trends in Genetics.2013; 29(5): 318. CrossRef
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
Alfredo Castello, Bernd Fischer, Katrin Eichelbaum, Rastislav Horos, Benedikt M. Beckmann, Claudia Strein, Norman E. Davey, David T. Humphreys, Thomas Preiss, Lars M. Steinmetz, Jeroen Krijgsveld, Matthias W. Hentze
Cell.2012; 149(6): 1393. CrossRef
Alternative splicing interference by xenobiotics
Emanuela Zaharieva, J. Kevin Chipman, Matthias Soller
Toxicology.2012; 296(1-3): 1. CrossRef
Neural antigen‐specific autoimmune disorders
Raffaele Iorio, Vanda A. Lennon
Immunological Reviews.2012; 248(1): 104. CrossRef
Paraneoplastic encephalomyelopathies: pathology and mechanisms
Andrew McKeon, Sean J. Pittock
Acta Neuropathologica.2011; 122(4): 381. CrossRef

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