Cancer Research and Treatment

Original Articles

Endocrine Cancer

Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea: Tung Hoang, Dayoung Song, Jeonghee Lee, Eun Kyung Lee, Yul Hwangbo, Jeongseon Kim; Cancer Res Treat. 2021;53(3):857-873. Published online December 7, 2020; DOI: https://doi.org/10.4143/crt.2020.720

Purpose
Obesity has been determined to be associated with fat mass and obesity-associated (FTO) gene and thyroid cancer risk. However, the effect of combined interactions between obesity and the FTO gene on thyroid cancer needs further investigation. This study aimed to examine whether interactions between body mass index (BMI) and the FTO gene are associated with an increased risk of thyroid cancer.
Materials and Methods
A total of 705 thyroid cancer cases and 705 sex- and age-matched normal controls were selected from the Cancer Screenee Cohort in National Cancer Center, Korea. A conditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the measure of associations and the combined effect of BMI and FTO gene on thyroid cancer.
Results
BMI was associated with an increased risk of thyroid cancer in subclasses of overweight (23-24.9 kg/m²; adjusted OR, 1.50; 95% CI, 1.12 to 2.00) and obese (≥ 25 kg/m²) (adjusted OR, 1.62; 95% CI, 1.23 to 2.14). There were positive associations between the FTO genetic variants rs8047395 and rs8044769 and an increased risk of thyroid cancer. Additionally, the combination of BMI subclasses and FTO gene variants was significantly associated with thyroid cancer risk in the codominant (rs17817288), dominant (rs9937053, rs12149832, rs1861867, and rs7195539), and recessive (rs17817288 and rs8044769) models.
Conclusion
Findings from this study identified the effects of BMI on thyroid cancer risk among individuals carrying rs17817288, rs9937053, rs12149832, rs1861867, rs7195539, and rs8044769, whereas the effects of BMI may be modified according to individual characteristics of other FTO variants.

Citations

Citations to this article as recorded by

Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta‐Analysis
Fengran Guo, Yilong Gao, Hu Wang, Pengfei Zhou, Yanping Zhang, Zhihai Teng, Yaxuan Wang, Zhenwei Han
Cancer Reports.2025;[Epub] CrossRef
Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study
Giacomo Di Filippo, Gian Luigi Canu, Giovanni Lazzari, Dorin Serbusca, Eleonora Morelli, Paolo Brazzarola, Leonardo Rossi, Benard Gjeloshi, Mariangela Caradonna, George Kotsovolis, Ioannis Pliakos, Efthymios Poulios, Theodosios Papavramidis, Federico Capp
Cancers.2024; 16(7): 1429. CrossRef
Analysis of Body Mass Index and Clinicopathological Factors in Patients with Papillary Thyroid Carcinoma
Wei Yan, Xue Luo, Qing-Jun Gao, Bing-Feng Chen, Hui Ye
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2013. CrossRef
Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway
Bo-Tao Zhang, Ying Li, Qi-Lan Jiang, Rui Jiang, Yang Zeng, Jun Jiang
Annals of Medicine.2024;[Epub] CrossRef
The association of obesity with thyroid carcinoma risk
Xiao‐Ni Ma, Cheng‐Xu Ma, Li‐Jie Hou, Song‐Bo Fu
Cancer Medicine.2022; 11(4): 1136. CrossRef
Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer
Tung Hoang, Eun Kyung Lee, Jeonghee Lee, Yul Hwangbo, Jeongseon Kim
Endocrinology and Metabolism.2022; 37(3): 513. CrossRef
Low-Level Environmental Mercury Exposure and Thyroid Cancer Risk Among Residents Living Near National Industrial Complexes in South Korea: A Population-Based Cohort Study
Seyoung Kim, Sang-Hwan Song, Chul-Woo Lee, Jung-Taek Kwon, Eun Young Park, Jin-Kyoung Oh, Hyun-Jin Kim, Eunjung Park, Byungmi Kim
Thyroid.2022; 32(9): 1118. CrossRef
Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study
Yoonyoung Jang, Taehwa Kim, Brian H. S. Kim, Boyoung Park
Cancers.2022; 14(19): 4712. CrossRef
FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma
Feng Xiao, Jianrong Zhou
Pharmacogenomics and Personalized Medicine.2021; Volume 14: 1239. CrossRef

7,282 View
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9 Web of Science
9 Crossref

Development and Evaluation of a Korean Version of a Thyroid-Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patients: Chang Hwan Ryu, Boram Park, Junsun Ryu, Youn Mi Ryu, Seong Ae Jo, You Jin Lee, Eun-Kyung Lee, Yul Hwangbo, Jungnam Joo, Yuh-Seog Jung; Cancer Res Treat. 2018;50(2):405-415. Published online May 26, 2017; DOI: https://doi.org/10.4143/crt.2017.012

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to develop a Korean version of the self-reported thyroid-specific quality of life (QoL) questionnaire for thyroid cancer patients (KT-QoL), and to evaluate its reliability and validity.
Materials and Methods
Two hundred seventy-two patients who underwent thyroidectomy from January to December 2010 were recruited in this study. The original version of the thyroid QoL was translated into Korean and evaluated for its reliability and validity. Using the developed KT-QoL, the postoperative QoL was evaluated until postoperative 1 year.
Results
At the preoperative baseline, the item internal consistency (IIC) ranged from ‒0.19 to 0.76, with low IIC values for items 2, 17, and 27. Item discriminant validity ranged from 86% to 97%. These values were similar at the postoperative periods. The internal consistency reliability (Cronbach’s α) was high for all dimensions, ranging from 0.90 to 0.95. The test-retest reliability (intraclass correlation coefficient) was acceptable (0.74-0.82). The external validity examined by the correlation between the item 1j (voice changes) of KT-QoL and the voice handicap index-30 ranged from 0.51 to 0.75. Patients’ QoL scores decreased after surgery, which demonstrated the sensitivity of the questionnaire. The QoL scores in patients with lobectomy showed best QoL scores postoperatively and those with receiving radioactive iodine still showed decreased QoL scores along the postoperative periods.
Conclusion
These results demonstrate that KT-QoL is a valid instrument for evaluating QoL of Korean patients with thyroid cancer.

Citations

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Health-Related Quality of Life in Patients with Low-Risk Differentiated Thyroid Cancer: A Systematic Review Examining the Extent of Thyroidectomy
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