Cancer Research and Treatment

Original Articles

Lung and Thoracic cancer

Long-term Exposure to PM₁₀ Increases Lung Cancer Risks: A Cohort Analysis: Hyun Woo Lee, Sung-Chan Kang, Sun-Young Kim, Young-Jae Cho, Seungsik Hwang; Cancer Res Treat. 2022;54(4):1030-1037. Published online January 17, 2022; DOI: https://doi.org/10.4143/crt.2021.1030

Abstract PDF Supplementary Material PubReader ePub

Purpose
Although lung cancer incidences in female never-smokers have increased, few studies focus on explicit investigation. We aimed to investigate the relationship between long-term exposure to ambient particulate matter sized 10 μm or less in diameter (PM₁₀) and the incidence of lung cancer within different genders and smoking status populations.
Materials and Methods
We included Seoul metropolitan residents, aged between 20 and 65 years, who underwent a national health screening examination from 2005-2007 and were followed up until 2015. Individual-level long-term exposure to PM₁₀ was assessed based on subject home addresses. To assess the relationship between PM₁₀ and lung cancer, we estimated hazard ratios (HRs) for increased lung cancer incidence from a 10 µg/m³ increase in PM₁₀.
Results
Among 5,831,039 individuals, 36,225 (0.6%) developed lung cancer within the 7 years observed. In females, the majority (94.4%) of lung cancer development was found in never-smokers. In adjusted analyses, a significant relationship between lung cancer development and PM₁₀ was observed in males, regardless of smoking status (never-smoker: HR, 1.14 [95% confidence interval (CI), 1.13 to 1.15]; ex-smoker: HR, 1.16 [95% CI, 1.14 to 1.17]; current smoker: HR, 1.18 [95% CI, 1.17 to 1.19]). We also found significant associations in female never- or ex-smokers with smaller HRs (never-smoker: HR, 1.06 [95% CI, 1.05 to 1.07]; ex-smoker: HR, 1.13 [95% CI, 1.02 to 1.23]; current smoker: HR, 1.04 [95% CI, 0.99 to 1.10]).
Conclusion
Our findings suggest that long-term exposure to PM₁₀ is associated with lung cancer development. A novel approach to lung cancer screening needs to be considered depending on the exposed PM₁₀ level.

Citations

Citations to this article as recorded by

Lung Cancer in Women: The Past, Present, and Future
Narjust Florez, Lauren Kiel, Ivy Riano, Shruti Patel, Kathryn DeCarli, Natasha Dhawan, Ivy Franco, Ashley Odai-Afotey, Kelly Meza, Nishwant Swami, Jyoti Patel, Lecia V. Sequist
Clinical Lung Cancer.2024; 25(1): 1. CrossRef
Impact of air pollution on cardiorespiratory morbidities in Southern Thailand
Suhaimee Buya, Apiradee Lim, Rattikan Saelim, Salang Musikasuwan, Thitiworn Choosong, Nutta Taneepanichskul
Clinical Epidemiology and Global Health.2024; 25: 101501. CrossRef
Lung cancer screening for never smokers: current evidence and future directions
Kay Choong See
Singapore Medical Journal.2024;[Epub] CrossRef
Airborne particulate matter integral assessment in Magdalena department, Colombia: Patterns, health impact, and policy management
Eliana Vergara-Vásquez, Luis M. Hernández Beleño, Tailin T. Castrillo-Borja, Tomás R. Bolaño-Ortíz, Yiniva Camargo-Caicedo, Andrés M. Vélez-Pereira
Heliyon.2024; 10(16): e36284. CrossRef
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The dysfunctionality of hippocampal synapses may be directly related to PM-induced impairments in spatial learning and memory in juvenile rats
Jianxiong Gui, Jie Liu, Ziyao Han, Xiaoyue Yang, Ran Ding, Jiaxin Yang, Hanyu Luo, Dishu Huang, Hengsheng Chen, Li Cheng, Li Jiang
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Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
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Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer: Hyung-Jun Kim, Jun Yeun Cho, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Sukki Cho, Kwhanmien Kim, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee; Cancer Res Treat. 2019;51(4):1540-1548. Published online March 25, 2019; DOI: https://doi.org/10.4143/crt.2019.057

Abstract PDF Supplementary Material PubReader ePub

Purpose
Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival.
Materials and Methods
Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed.
Results
Among 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91).
Conclusion
Concurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients.

Citations

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