Cancer Research and Treatment

Reversible Proximal Renal Tubular Dysfunction after One-Time Ifosfamide Exposure: Young Il Kim, Ju Young Yoon, Jun Eul Hwang, Hyun Jeong Shim, Woo Kyun Bae, Sang Hee Cho, Ik-Joo Chung; Cancer Res Treat. 2010;42(4):244-246. Published online December 31, 2010; DOI: https://doi.org/10.4143/crt.2010.42.4.244

The alkylating agent ifosfamide is an anti-neoplastic used to treat various pediatric and adult malignancies. Its potential urologic toxicities include glomerulopathy, tubulopathy and hemorrhagic cystitis. This report describes a case of proximal renal tubular dysfunction and hemorrhagic cystitis in a 67-year-old male given ifosfamide for epitheloid sarcoma. He was also receiving an oral hypoglycemic agent for type 2 diabetes mellitus and had a baseline glomerular filtration rate of 51.5 mL/min/1.73 m². Despite mesna prophylaxis, the patient experienced dysuria and gross hematuria after a single course of ifosfamide plus adriamycin. The abrupt renal impairment and serum/urine electrolyte imbalances that ensued were consistent with Fanconi's syndrome. However, normal renal function and electrolyte status were restored within 14 days, simply through supportive measures. A score of 8 by Naranjo adverse drug reaction probability scale indicated these complications were most likely treatment-related, although they developed without known predisposing factors. The currently undefined role of diabetic nephropathy in adult ifosfamide nephrotoxicity merits future investigation.

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Expression of p53, bcl-2 Protein in Small Cell Lung Cancer (SCLC) Cell Lines in Relation to Sensitivity to Chemotherapy: In Sook Woo, Myung Jae Park, Young Seok Park, Sung Won Jung, Mi Ae Yeo, Soo Hyun Park, Si Young Kim, Hwi Joong Yoon, Kyung Sam Cho, Jae Kyung Park, Young Il Kim; J Korean Cancer Assoc. 2000;32(5):904-910.

Abstract PDF: PURPOSE
Sensitivity of tumor cells to chemotherapeutic regimen may be accentuated by their abnormal expression of oncogene. p53 is required for the efficient activation of apoptosis following irradiation or treatment with chemotherapeutic agents. The aim of this study was to evaluate the relationship between chemosensitivity and apoptosis related proteins such as p53, bcl-2 in small cell lung cancer cell lines. MATERIAL AND METHODS: Six human small cell lung cancer cell lines, NCI-H69, NCI-H128, NCI-H1436, NCI-H1092, derived from untreated and treated patients were tested for chemo sensitivity and the expression of the p53, bcl-2 genes were examined in each cell lines with western blot analysis. We used 4 drugs including adriamycin, cisplatin, vincristine and VP-16.
RESULTS
NCI-H128 was the most sensitive cell line to four drugs. NCI-H82 and NCI-H1092 were highly resistant to VP-16, adriamycin and vincristine and determination of an IC50 was not possible. In western blot analysis, NCI-H128 alone was strong positive to p53 monoclonal antibody and the rest of cell lines were negative. All but NCI-H128 were positive to bcl-2 monoclonal antibody. NCI-H128 which was strong positive to p53 and negative to bcl-2. NCI-H1092 was strong positive to bcl-2 and negative to p53 monoclonal antibody.
CONCLUSION
We were not able to explain the expression of p53 in small cell lung cancer cell lines in relation to senitivity to anti-cancer chemotherapeutic agents. But the expression of bcl-2 in small cell lung cancer cell lines was correlated with the chemosensitivity well.

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The immunological characteristics of tumor infiltrating lymphocytes and tumor draining lymph node lymphocytes in advanced stomach cancer: Jae Yong Lee, Jung Soon Jang, Young Iee Park, Noe Kyeong Kim, Chee Young Choe, Woo Ho Kim, Chul Woo Kim, Young Il Kim, Dae Seog Heo, Woo Hyun Chang; J Korean Cancer Assoc. 1992;24(5):656-665.

Abstract PDF: No abstract available.

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Lymphokine-activated killer(LAK) cell activity in tumor-transplanted mice(II): Sang Yun Nam, Yun Tai Lee, Young Il Kim, Si Young Kim, Kyung Sam Cho; J Korean Cancer Assoc. 1992;24(3):365-377.

Abstract PDF: No abstract available.

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The effect of inductive chemotherapy with FAC regimen on breast cancer: Eil Sung Chang, Young Il Kim; J Korean Cancer Assoc. 1991;23(4):783-789.

Abstract PDF: No abstract available.

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Lymphokine-activated killer(LAK) cell activity in tumor-transplanted mice(I): Sang Yun Nam, Yun Tai Lee, Young Il Kim, Si Young Kim, Kyung Sam Cho; J Korean Cancer Assoc. 1991;23(2):218-229.

Abstract PDF: No abstract available.

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Antigen Receptor Gene Rearrangement Patterans of Acute Lymphoblastic Leukemia - Preliminary study of detection of residual leukemic cells using polymerase chain r: Kyung Sam Cho, Young Il Kim, Seon Hee Kim, Si Young Kim, Hwi Joong Yoon; J Korean Cancer Assoc. 1994;26(4):591-599.

Abstract PDF: 1) Background: Polymerase chain reaction (PCR) is a highly sensitive method to detect minimal residual disease (MRD). Although leukemia-specific translocations are detected only in minority of patients with acute lymphoblastic leukemia (ALL), several investigators developed methods to detect MRD by PCR, based on preferential usage of specific genetic elements, the limited number of VB and JB elements of T cell receptor (TCR) delta gene, and assembled V regions of immunoglobulin (Ig) gene containing re1atively conserved base sequences. 2) Methods: We evaluated antigen receptor gene rearrangement patterns of leukemic cells from ALL patients by southern blot technique, as a baseline study for the detection of MRD using PCR. 3) Results: Rearrangements of Ig heavy chain, TCR beta, gamma and delta chain gene were found in 68%, 68%, 64%, 9B% of patients respectively. So thern analysis of HindIII digests with JBS16 probe showed Vδ[Jδ] rearrangement in only 4 cases. 4) Conclusion: Heavy chain gene rearrangement is more suitable target for the application of PCR than TCR delta gene rearrangements for detection of MRD in ALL.

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