Cancer Research and Treatment

Original Articles

Genitourinary cancer

TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort: Sang Hun Song, Jaewon Lee, Young Hwii Ko, Jong Wook Kim, Seung Il Jung, Seok Ho Kang, Jinsung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, Jong Jin Oh; Cancer Res Treat. 2023;55(4):1337-1345. Published online April 17, 2023; DOI: https://doi.org/10.4143/crt.2023.417

Abstract PDF Supplementary Material PubReader ePub

Purpose
Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses.
Materials and Methods
Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was conducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted.
Results
UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor ≥ pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1-2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in ≥ pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients.
Conclusion
Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC.

Citations

Citations to this article as recorded by

Clinical Presentation and Targeted Interventions in Urachal Adenocarcinoma: A Single-Institution Case Series and Review of Emerging Therapies
Akshay Mathavan, Akash Mathavan, Rodrigo Murillo-Alvarez, Kriti Gera, Urszula Krekora, Aaron J. Winer, Mohit Mathavan, Ellery Altshuler, Brian Hemendra Ramnaraign
Clinical Genitourinary Cancer.2024; 22(1): 67. CrossRef
Robotic‐assisted approaches to urachal carcinoma: A comprehensive systematic review of the safety and efficacy outcomes
Caio Vinícius Suartz, Lucas Motta Martinez, Pedro Henrique Brito, Carlos Victori Neto, Maurício Dener Cordeiro, Luiz Antonio Assan Botelho, Fábio Pescarmona Gallucci, José Maurício Mota, William Carlos Nahas, Leopoldo Alves Ribeiro‐Filho
BJUI Compass.2024; 5(3): 327. CrossRef

3,777 View
208 Download
3 Web of Science
2 Crossref

Decision Based on Narrow Band Imaging Cystoscopy without a Referential Normal Standard Rather Increases Unnecessary Biopsy in Detection of Recurrent Bladder Urothelial Carcinoma Early after Intravesical Instillation: Phil Hyun Song, Seok Cho, Young Hwii Ko; Cancer Res Treat. 2016;48(1):273-280. Published online March 2, 2015; DOI: https://doi.org/10.4143/crt.2014.190

Abstract PDF PubReader ePub

Purpose
The purpose of this study was to calculate the operating characteristics of narrowband imaging (NBI) cystoscopy versus traditional white light cystoscopy (WLC) in common clinical scenarios involving suspicion of bladder urothelial carcinoma (UC). Materials and Methods Sixty-three consecutive patients initially underwent WLC and then NBI in a single session for evaluation of microscopic hematuria (group I, n=20), gross hematuria (group II, n=19), and follow-up for prior UC (group III, n=24), by an experienced urologist. All lesions that were abnormal in contrast with adjacent normal mucosa were diagnosed as positive and biopsied.
Results
Sixty-six biopsies from 47 patients were performed. Pathologic examination showed 17 cases of UC from 21 sites. While the overall sensitivity of NBI was similar to that of WLC (100% vs. 94.1%), the specificity of NBI was significantly lower than that of WLC (50% vs. 86.9%, p < 0.001), particularly in group III (38.9% vs. 88.9%, p=0.004). Based on identification by NBI only, 23 additional biopsies from 18 cases were performed for identification of one patient with UC, who belonged to group III. In this group, to identify this specific patient, 15 additional biopsies were performed from 10 patients. All seven cases with positive findings from NBI within 2 months after the last intravesical therapy were histologically proven as negative. Conclusion In evaluation for recurrence early after intravesical instillation, the decision based on NBI increased unnecessary biopsy in the absence of an established standard for judging NBI.

Citations

Citations to this article as recorded by

Comparison of narrow band imaging versus white light imaging in detecting non muscle invasive bladder cancer
Raghavendra RT, Amit Sharma, Deepak Biswal, Saryu Goel
Urologia Journal.2024; 91(2): 289. CrossRef
Advanced optical imaging techniques for bladder cancer detection and diagnosis: a systematic review
Marinka J. Remmelink, Yael Rip, Jakko A. Nieuwenhuijzen, Johannes C.F. Ket, Jorg R. Oddens, Theo M. de Reijke, Daniel M. de Bruin
BJU International.2024; 134(6): 890. CrossRef
Differentiation of Urothelial Carcinoma and Normal Bladder Tissues by Means of Fiber-Based ATR IR Spectroscopy
Rimantė Bandzevičiūtė, Gediminas Platkevičius, Justinas Čeponkus, Arūnas Želvys, Albertas Čekauskas, Valdas Šablinskas
Cancers.2023; 15(2): 499. CrossRef
Development and validation of a predictive model for the diagnosis of bladder tumors using narrow band imaging
Hao Liang, Qingya Yang, Yaozhong Zhang, Hui Sun, Qiang Fu, Tongxiang Diao, Jin Wang, Wei Huang, Yang Xu, Nan Ge, Xuewen Jiang, Shouzhen Chen, Yan Li, Bin Zhou, Peixin Li, Xiaoyi Zhang, Nianzhao Zhang, Benkang Shi, Jun Chen
Journal of Cancer Research and Clinical Oncology.2023; 149(17): 15867. CrossRef
Role of Macroscopic Image Enhancement in Diagnosis of Non-Muscle-Invasive Bladder Cancer: An Analytical Review
Prashant Motiram Mulawkar, Gyanendra Sharma, Ashwin Tamhankar, Utsav Shah, Rickaz Raheem
Frontiers in Surgery.2022;[Epub] CrossRef
Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis
Giorgio I. Russo, Tamir N. Sholklapper, Andrea Cocci, Giuseppe Broggi, Rosario Caltabiano, Angela B. Smith, Yair Lotan, Giuseppe Morgia, Ashish M. Kamat, J. Alfred Witjes, Siamak Daneshmand, Mihir M. Desai, Indebir S. Gill, Giovanni E. Cacciamani
Cancers.2021; 13(17): 4378. CrossRef
Postoperative Recurrent Bladder Tumors Detection by Narrow-Band Imaging Cystoscopy
Won Tae Seo, Su Hwan Kang
The Korean Journal of Urological Oncology.2020; 18(3): 209. CrossRef
Blue-light cystoscopy and narrow-band imaging in bladder cancer management
Zhijiang Zang, Qinghui Wu, Edmund Chiong
Formosan Journal of Surgery.2019; 52(5): 155. CrossRef
Usefulness of narrow-band imaging in transurethral resection of bladder tumor: Early experience from a tertiary center in India
Kanuj Malik, Anand Raja, Sivakumar Mahalingam, L.S Ravishankar
South Asian Journal of Cancer.2019; 08(04): 226. CrossRef
Diagnostic performance of image technique based transurethral resection for non-muscle invasive bladder cancer: systematic review and diagnostic meta-analysis
Changhao Chen, Hao Huang, Yue Zhao, Hao Liu, Richard Sylvester, Tianxin Lin, Jian Huang
BMJ Open.2019; 9(10): e028173. CrossRef
Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy
Seung Bin Kim, Sung Goo Yoon, Jonghyun Tae, Jae Yoon Kim, Ji Sung Shim, Sung Gu Kang, Jun Cheon, Jeong Gu Lee, Je Jong Kim, Seok Ho Kang
Investigative and Clinical Urology.2018; 59(2): 98. CrossRef
A meta-analysis of narrow band imaging for the diagnosis and therapeutic outcome of non-muscle invasive bladder cancer
YiQuan Xiong, JianDong Li, ShuJuan Ma, Jing Ge, LiZhi Zhou, Dongliang Li, Qing Chen, Robert Hurst
PLOS ONE.2017; 12(2): e0170819. CrossRef
Narrow band imaging-assisted transurethral resection reduces the recurrence risk of non-muscle invasive bladder cancer: A systematic review and meta-analysis
Weiting Kang, Zilian Cui, Qianqian Chen, Dong Zhang, Haiyang Zhang, Xunbo Jin
Oncotarget.2017; 8(14): 23880. CrossRef
Narrow band imaging for bladder cancer
Thomas Y. Hsueh, Allen W. Chiu
Asian Journal of Urology.2016; 3(3): 126. CrossRef

13,677 View
87 Download
14 Web of Science
14 Crossref

Biopsy Related Prostate Status Does Not Affect on the Clinicopathological Outcome of Robotic Assisted Laparoscopic Radical Prostatectomy: Hoon Choi, Young Hwii Ko, Sung Gu Kang, Seok Ho Kang, Hong Seok Park, Jun Cheon, Vipul R. Patel; Cancer Res Treat. 2009;41(4):205-210. Published online December 31, 2009; DOI: https://doi.org/10.4143/crt.2009.41.4.205

Abstract PDF PubReader ePub

Purpose

To determine whether the biopsy core number and time interval between prostate biopsy and radical prostatectomy affect the operative and oncologic outcome of robot assisted laparoscopic radical prostatectomy (RALP).

Materials and Methods

From January 2008 to April 2009, a single surgeon performed 72 RALPs after an initial learning period of 30 cases. The relationship between time from biopsy to prostatectomy and biopsy core number with operative time and estimated blood loss (EBL) were initially evaluated with a linear regression model. These patients were classified into groups according to whether the interval from biopsy to RALP was within four weeks or not, and whether there were less than or greater than 10 core specimens removed.

Results

RALP was performed in 34 patients within four weeks of biopsy, and in 38 patients more than 4 weeks after biopsy. According to the number of core specimens removed, less than 10 cores were performed in 10 patients, and more than 10 cores were performed in 62 patients. Using an interval of 4 weeks as the cutoff point, early surgery was associated with longer operating time (232.6 vs 208.8 min) and increased estimated blood loss (305.1 vs 276.9 mL). For cases with more than 10 biopsy cores, there was a slight increase in operative time (229.2 vs 210.3 min). None of these differences were statistically significant by multivariate analysis.

Conclusion

Our data suggests that there is no reason to delay RALP to more than 4 weeks after prostate biopsy. It also revealed that the number of biopsy cores (up to 14) did not influence operative outcome. Thus, RALP is a feasible procedure regardless of the biopsy related prostate state.

Citations

Citations to this article as recorded by

Effect of Transperineal Versus Transrectal Prostate Biopsy on the Quality of Hydrogel Spacer Placement in Men Prior to Radiation Therapy for Prostate Cancer
Michael E. Rezaee, Ulysses Gardner, Mark N. Alshak, Stephen C. Greco, Daniel Y. Song, Michael Goldstein, Christian P. Pavlovich
Urology.2023; 182: 27. CrossRef
Does time interval between prostate biopsy and surgery affect outcomes of radical prostatectomy? A systematic review and meta-analysis
Jie Li, Qing Jiang, Qiubo Li, Yuanfeng Zhang, Liang Gao
International Urology and Nephrology.2020; 52(4): 619. CrossRef
Short interval of biopsy to robotic-assisted laparoscopic radical prostatectomy does not render any adverse effects on the perioperative outcomes
Minke He, Yaohui Li, Zhuoyi Xiang, Li-an Sun, Yanjun Zhu, Xiaoyi Hu, Jianming Guo, Hang Wang
Medicine.2018; 97(36): e11686. CrossRef
A Multidimensional Analysis of Prostate Surgery Costs in the United States: Robotic-Assisted versus Retropubic Radical Prostatectomy
Akash Bijlani, April E. Hebert, Mike Davitian, Holly May, Mark Speers, Robert Leung, Nihal E. Mohamed, Henry S. Sacks, Ashutosh Tewari
Value in Health.2016; 19(4): 391. CrossRef
Interval from Prostate Biopsy to Radical Prostatectomy Does Not Affect Immediate Operative Outcomes for Open or Minimally Invasive Approach
Bumsoo Park, Seol Ho Choo, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi
Journal of Korean Medical Science.2014; 29(12): 1688. CrossRef
Interval from Prostate Biopsy to Robot-Assisted Laparoscopic Radical Prostatectomy (RALP): Effects on Surgical Difficulties
In Sung Kim, Woong Na, Jung Su Nam, Jong Jin Oh, Chang Wook Jeong, Sung Kyu Hong, Seok Soo Byun, Sang Eun Lee
Korean Journal of Urology.2011; 52(10): 664. CrossRef
Prostate-Specific Antigen Density as a Powerful Predictor of Extracapsular Extension and Positive Surgical Margin in Radical Prostatectomy Patients with Prostate-Specific Antigen Levels of Less than 10 ng/ml
Jin-Seok Chang, Hoon Choi, Young-Seop Chang, Jin-Bum Kim, Mi Mi Oh, Du Geon Moon, Jae Hyun Bae, Jun Cheon
Korean Journal of Urology.2011; 52(12): 809. CrossRef

9,630 View
51 Download
7 Crossref

A Matched-cohort Comparison of Laparoscopic Renal Cryoablation using Ultra-thin Cryoprobes with Open Partial Nephrectomy for the Treatment of Small Renal Cell Carcinoma: Young Hwii Ko, Hong Seok Park, Du Geon Moon, Jeong Gu Lee, Je Jong Kim, Duck Ki Yoon, Seok Ho Kang, Jun Cheon; Cancer Res Treat. 2008;40(4):184-189. Published online December 31, 2008; DOI: https://doi.org/10.4143/crt.2008.40.4.184

Abstract PDF PubReader ePub

Purpose

To evaluate the feasibility and efficacy of performing laparoscopic renal cryoablation (LRC) for the treatment of RCC, as compared with open partial nephrectomy (OPN), which is the established NSS.

Materials and Methods

From April 2004, among the patients who underwent LRC with a 1.47 mm cryoprobe, we enrolled 20 patients who were pathologically confirmed as having RCC with a tumor size smaller than 4 cm. These patients were matched with a group of 20 patients, who were selected based on the pre-operative characteristics of the tumor and those of the patients, from a pre-existing database of the patients who underwent OPN during the same period.

Results

The mean age and tumor size were 56.3±11.5 years and 2.4±1.7 cm in the LRC group, and 57.6±10.9 years and 2.2±1.1 cm in the OPN group. The two groups were similar for their age, gender, BMI, ASA, the tumor characteristics and the indications for operation. While the pathologic results and the operation time showed similarity, the EBL (98±87 ml vs 351±147 ml, respectively, p=0.001), the transfusion rate (10% vs 40%, respectively, p=0.03) and the hospital stay (4.2±1.5 days vs 8.2±2.4 days, respectively, p=0.005) were significantly less in the LRC group. Major complications did not occur in the LRC group, but in the OPN group, one patient experienced urine leakage and one patient had a perirenal hematoma. During the mean follow up of 27.3±10.8 months and 28.7±14.9 months for each group, respectively, all the patients remained disease-free with no evidence of local recurrence or metastases.

Conclusions

LRC using ultra-thin cryoprobes for the treatment of small RCC showed similar effective oncologic results with the merits of minimal invasiveness, as compared with OPN, during the intermediate term follow up.

Citations

Citations to this article as recorded by

Comparative efficacy and safety of ablative therapies in the management of primary localised renal cell carcinoma: a systematic review and meta-analysis
Ryan S Huang, Ronald Chow, Ali Benour, David Chen, Gabriel Boldt, Christopher J D Wallis, Anand Swaminath, Charles B Simone, Michael Lock, Srinivas Raman
The Lancet Oncology.2025; 26(3): 387. CrossRef
Stage IA papillary and chromophobe renal cell carcinoma: effectiveness of cryoablation and partial nephrectomy
Annemarie Uhlig, Johannes Uhlig, Brian Shuch, Hyun S. Kim
Insights into Imaging.2024;[Epub] CrossRef
Differential efficacy of ablation therapy versus partial nephrectomy between clinical T1a and T1b renal tumors: A systematic review and meta-analysis
Takafumi Yanagisawa, Keiichiro Mori, Tatsushi Kawada, Reza Sari Motlagh, Hadi Mostafaei, Fahad Quhal, Ekaterina Laukhtina, Pawel Rajwa, Abdulmajeed Aydh, Frederik König, Maximilian Pallauf, Benjamin Pradere, Jun Miki, Takahiro Kimura, Shin Egawa, Shahrokh
Urologic Oncology: Seminars and Original Investigations.2022; 40(7): 315. CrossRef
Partial nephrectomy vs cryoablation for T1a renal cell carcinoma: A comparison of survival benefit stratified by tumour size
Xinyang Liao, Shi Qiu, Wanyu Wang, Xiaonan Zheng, Kun Jin, Shiyu Zhang, Yige Bao, Lu Yang, Qiang Wei
Cancer Epidemiology.2019; 59: 221. CrossRef
Partial nephrectomy versus ablative therapies for cT1a renal masses: A Systematic Review and meta-analysis
Xu Hu, Yan-Xiang Shao, Yan Wang, Zhi-Qiang Yang, Wei-Xiao Yang, Xiang Li
European Journal of Surgical Oncology.2019; 45(9): 1527. CrossRef
Comparison among cryoablation, radiofrequency ablation, and partial nephrectomy for renal cell carcinomas sized smaller than 2 cm or sized 2–4 cm
Shuai Yan, Wei Yang, Cheng-mei Zhu, Pei-meng Yan, Zhi-chao Wang
Medicine.2019; 98(21): e15610. CrossRef
Ablative Therapy for Small Renal Masses
Benjamin L. Taylor, S. William Stavropoulos, Thomas J. Guzzo
Urologic Clinics of North America.2017; 44(2): 223. CrossRef
A national study of kidney graft tumor treatments: Toward ablative therapy
Kerem Guleryuz, Arnaud Doerfler, Ricardo Codas, Grégoire Coffin, Jacques Hubert, Eric Lechevallier, Xavier Tillou, L. Badet, B. Barrou, T. Bessede, P. Blanchet, J.M. Boutin, J. Branchereau, T. Culty, V. Delaporte, F. Gaudez, M. Gigante, G. Karam, F. Klein
Surgery.2016; 160(1): 237. CrossRef
Guía de manejo del carcinoma de células renales
William Quiroga Matamoros, Fernando Fernandez, Danilo Citarella Otero, Jaime Rangel, Andrea Estrada Guerrero, Iván Darío Patiño
Urología Colombiana.2016; 25(2): 169. CrossRef
Current Status of Cryotherapy for Prostate and Kidney Cancer
Seok Cho, Seok Ho Kang
Korean Journal of Urology.2014; 55(12): 780. CrossRef
Retrospective Comparison of Laparoscopic Partial Nephrectomy Versus Laparoscopic Renal Cryoablation for Small (<3.5 cm) Cortical Renal Masses
Georgios Haramis, Joseph A. Graversen, Adam C. Mues, Ruslan Korets, Juan Carlos Rosales, Zhamshid Okhunov, Ketan K. Badani, Mantu Gupta, Jaime Landman
Journal of Laparoendoscopic & Advanced Surgical Techniques.2012; 22(2): 152. CrossRef
Systematic Review of Perioperative and Quality-of-life Outcomes Following Surgical Management of Localised Renal Cancer
Steven MacLennan, Mari Imamura, Marie C. Lapitan, Muhammad Imran Omar, Thomas B.L. Lam, Ana M. Hilvano-Cabungcal, Pam Royle, Fiona Stewart, Graeme MacLennan, Sara J. MacLennan, Philipp Dahm, Steven E. Canfield, Sam McClinton, T.R. Leyshon Griffiths, Börje
European Urology.2012; 62(6): 1097. CrossRef
Systematic Review of Oncological Outcomes Following Surgical Management of Localised Renal Cancer
Steven MacLennan, Mari Imamura, Marie C. Lapitan, Muhammad Imran Omar, Thomas B.L. Lam, Ana M. Hilvano-Cabungcal, Pam Royle, Fiona Stewart, Graeme MacLennan, Sara J. MacLennan, Steven E. Canfield, Sam McClinton, T.R. Leyshon Griffiths, Börje Ljungberg, Ja
European Urology.2012; 61(5): 972. CrossRef
Perioperative, Oncologic, and Functional Outcomes of Laparoscopic Renal Cryoablation and Open Partial Nephrectomy: A Matched Pair Analysis
Tobias Klatte, Julian Mauermann, Gertraud Heinz-Peer, Matthias Waldert, Peter Weibl, Hans Christoph Klingler, Mesut Remzi
Journal of Endourology.2011; 25(6): 991. CrossRef

9,583 View
81 Download
14 Crossref

First
Prev
Page of 1
Next
Last

Search