Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
2 "Yong-Oon Ahn"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Acquired Resistance of MET-Amplified Non-small Cell Lung Cancer Cells to the MET Inhibitor Capmatinib
Seulki Kim, Tae Min Kim, Dong-Wan Kim, Soyeon Kim, Miso Kim, Yong-Oon Ahn, Bhumsuk Keam, Dae Seog Heo
Cancer Res Treat. 2019;51(3):951-962.   Published online October 10, 2018
DOI: https://doi.org/10.4143/crt.2018.052
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Amplified mesenchymal-epithelial transition factor, MET, is a receptor tyrosine kinase (RTK) that has been considered a druggable target in non-small cell lung cancer (NSCLC). Although multiple MET tyrosine kinase inhibitors (TKIs) are being actively developed for MET-driven NSCLC, the mechanisms of acquired resistance to MET-TKIs have not been well elucidated. To understand the mechanisms of resistance and establish therapeutic strategies, we developed an in vitro model using the MET-amplified NSCLC cell line EBC-1.
Materials and Methods
We established capmatinib-resistant NSCLC cell lines and identified alternative signaling pathways using 3′ mRNA sequencing and human phospho-RTK arrays. Copy number alterations were evaluated by quantitative polymerase chain reaction and cell proliferation assay; activation of RTKs and downstream effectors were compared between the parental cell line EBC-1 and the resistant cell lines.
Results
We found that EBC-CR1 showed an epidermal growth factor receptor (EGFR)‒dependent growth and sensitivity to afatinib, an irreversible EGFR TKI. EBC-CR2 cells that had overexpression of EGFR-MET heterodimer dramatically responded to combined capmatinib with afatinib. In addition, EBC-CR3 cells derived from EBC-CR1 cells that activated EGFR with amplified phosphoinositide-3 kinase catalytic subunit α (PIK3CA) were sensitive to combined afatinib with BYL719, a phosphoinositide 3-kinase α (PI3Kα) inhibitor.
Conclusion
Our in vitro studies suggested that activation of EGFR signaling and/or genetic alteration of downstream effectors like PIK3CA were alternative resistance mechanisms used by capmatinib-resistant NSCLC cell lines. In addition, combined treatments with MET, EGFR, and PI3Kα inhibitors may be effective therapeutic strategies in capmatinib-resistant NSCLC patients.

Citations

Citations to this article as recorded by  
  • Immunohistochemical characteristics and potential therapeutic regimens of hepatoid adenocarcinoma of the stomach: a study of 139 cases
    Xuesong Yang, Yan Wu, Anqiang Wang, Xiuli Ma, Kai Zhou, Ke Ji, Xin Ji, Ji Zhang, Xiaojiang Wu, ZhongWu Li, Zhaode Bu
    The Journal of Pathology: Clinical Research.2024;[Epub]     CrossRef
  • My battle with cancer. Part 1
    Mikhail V. Blagosklonny
    Oncoscience.2024; 11: 1.     CrossRef
  • SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma
    Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
    Molecular Oncology.2024; 18(3): 641.     CrossRef
  • Synthetic approaches and application of representative clinically approved fluorine-enriched anti-cancer medications
    He-Nan Liu, Ying Zhu, Yuan Chi, Fei-Fei Sun, Li-Shen Shan, Ya-Tao Wang, Bing Dai
    European Journal of Medicinal Chemistry.2024; 276: 116722.     CrossRef
  • Multifunctional dendrimer-peptide conjugates for MET receptor-specific imaging of cancer cells
    Jin Woong Lee, Kwangok P. Nickel, Rachel L. Minne, Justin J. Jeffery, Eduardo Aluicio-Sarduy, Carter Kim, DaWon Kim, Piper A. Rawding, Michael J. Poellmann, Narsimha Mamidi, Jonathan W. Engle, Jung Heon Lee, Hansoo Park, Reinier Hernandez, Randall J. Kimp
    Nano Today.2024; 59: 102509.     CrossRef
  • Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics
    Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Val
    Genes & Diseases.2023; 10(3): 960.     CrossRef
  • Synergistic therapeutic potential of alpelisib in cancers (excluding breast cancer): Preclinical and clinical evidences
    Yuhao Ye, Zhiyu Huang, Maoqing Zhang, Jiayue Li, Yiqiong Zhang, Chenghua Lou
    Biomedicine & Pharmacotherapy.2023; 159: 114183.     CrossRef
  • Quinolines: Privileged Scaffolds for Developing New Anti‐neurodegenerative Agents
    M.Sc.Shivani Chauhan, Tarana Umar, Manpreet K. Aulakh
    ChemistrySelect.2023;[Epub]     CrossRef
  • A multiparametric fluorescent visualization approach for detecting drug resistance in living cancer cells
    Zhilan Zhou, Ya Wang, Zhengtao Shao, Guixi Zhang, Hang Jiang, Yiyuan Tang, Zening Huang, Yingdi Zhu, Juan Li
    Talanta.2023; 259: 124564.     CrossRef
  • Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy
    Chaofan Wang, Xiaoyun Lu
    Journal of Medicinal Chemistry.2023; 66(12): 7670.     CrossRef
  • Current Indications and Future Landscape of Bispecific Antibodies for the Treatment of Lung Cancer
    Hugo Arasanz, Luisa Chocarro, Leticia Fernández-Rubio, Ester Blanco, Ana Bocanegra, Miriam Echaide, Ibone Labiano, Ana Elsa Huerta, Maria Alsina, Ruth Vera, David Escors, Grazyna Kochan
    International Journal of Molecular Sciences.2023; 24(12): 9855.     CrossRef
  • An Observatory for the MET Oncogene: A Guide for Targeted Therapies
    Dogus M. Altintas, Paolo M. Comoglio
    Cancers.2023; 15(18): 4672.     CrossRef
  • Advances of clinically approved small-molecule drugs for the treatment of non-small cell lung cancer
    Zhen-Xi Niu, Ya-Tao Wang, Nan Lu, Jin-Feng Sun, Peng Nie, Piet Herdewijn
    European Journal of Medicinal Chemistry.2023; 261: 115868.     CrossRef
  • Epigenetic regulation in lung cancer
    Shahin Ramazi, Maedeh Dadzadi, Zahra Sahafnejad, Abdollah Allahverdi
    MedComm.2023;[Epub]     CrossRef
  • SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
    Brianna R. Daley, Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Zaria M. Beckley, Dianna H. Huisman, Deepan Chatterjee, Nancy E. Sealover, Katherine Cox, James W. Askew, Robert A. Svoboda, Kurt W. Fisher, Robert E. Lewis, Robert L. Kortum
    Proceedings of the National Academy of Sciences.2023;[Epub]     CrossRef
  • KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
    Juan Esteban Garcia-Robledo, Rafael Rosell, Alejandro Ruíz-Patiño, Carolina Sotelo, Oscar Arrieta, Lucia Zatarain-Barrón, Camila Ordoñez, Elvira Jaller, Leonardo Rojas, Alessandro Russo, Diego de Miguel-Pérez, Christian Rolfo, Andrés F. Cardona
    Therapeutic Advances in Respiratory Disease.2022;[Epub]     CrossRef
  • MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis
    Daniel Lu, Amy Nagelberg, Justine LM Chow, Yankuan T Chen, Quentin Michalchuk, Romel Somwar, William W. Lockwood
    Cancers.2022; 14(6): 1378.     CrossRef
  • hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
    Ilaria Martinelli, Chiara Modica, Cristina Chiriaco, Cristina Basilico, James M. Hughes, Simona Corso, Silvia Giordano, Paolo M. Comoglio, Elisa Vigna
    Journal of Experimental & Clinical Cancer Research.2022;[Epub]     CrossRef
  • PIK3CAMutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
    Aryana R. Rasti, Amy Guimaraes-Young, Farrah Datko, Virginia F. Borges, Dara L. Aisner, Elena Shagisultanova
    JCO Precision Oncology.2022;[Epub]     CrossRef
  • Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
    Yang Yang, Shuo Li, Yujiao Wang, Yi Zhao, Qiu Li
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef
  • MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies
    Solange Rivas, Arnaldo Marín, Suraj Samtani, Evelin González-Feliú, Ricardo Armisén
    International Journal of Molecular Sciences.2022; 23(22): 13898.     CrossRef
  • Advances in the Lung Cancer Immunotherapy Approaches
    Hafiza Padinharayil, Reema Rose Alappat, Liji Maria Joy, Kavya V. Anilkumar, Cornelia M. Wilson, Alex George, Abilash Valsala Gopalakrishnan, Harishkumar Madhyastha, Thiyagarajan Ramesh, Ezhaveni Sathiyamoorthi, Jintae Lee, Raja Ganesan
    Vaccines.2022; 10(11): 1963.     CrossRef
  • A comprehensive review on the biological interest of quinoline and its derivatives
    Basavarajaiah Suliphuldevara Matada, Raviraj Pattanashettar, Nagesh Gunavanthrao Yernale
    Bioorganic & Medicinal Chemistry.2021; 32: 115973.     CrossRef
  • Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer
    Fatemeh Moosavi, Elisa Giovannetti, Godefridus J. Peters, Omidreza Firuzi
    Critical Reviews in Oncology/Hematology.2021; 160: 103234.     CrossRef
  • Novel Therapies for Metastatic Non-Small Cell Lung Cancer with MET Exon 14 Alterations: A Spotlight on Capmatinib
    Aaron Tan, Tracy J Loh, Xue Lin Kwang, Gek San Tan, Kiat Hon Lim, Daniel SW Tan
    Lung Cancer: Targets and Therapy.2021; Volume 12: 11.     CrossRef
  • Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors
    Qing Tang, Alex M. Aronov, David D. Deininger, Simon Giroux, David J. Lauffer, Pan Li, Jianglin Liang, Kira McGinty, Steven Ronkin, Rebecca Swett, Nathan Waal, Diane Boucher, Pamella J. Ford, Cameron S. Moody
    ACS Medicinal Chemistry Letters.2021; 12(6): 955.     CrossRef
  • Tyrosine Kinase Inhibitors, Antibody-Drug Conjugates, and Proteolysis-Targeting Chimeras: The Pharmacology of Cutting-Edge Lung Cancer Therapies
    Jennifer W. Carlisle, R. Donald Harvey
    American Society of Clinical Oncology Educational Book.2021; (41): e286.     CrossRef
  • Response to crizotinib in a patient with MET‐amplified hepatocellular carcinoma
    Qinglian Chen, Chunfeng Xie, Kunliang Feng, Haijun Huang, Chengming Xiong, Tengjiao Lin, Wenjing Wang, Mian Xu, Xianwei Yang, Chong Zhong
    Hepatology Research.2021; 51(11): 1164.     CrossRef
  • New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications
    Thais Cristina Mendonça Nogueira, Marcus Vinicius Nora de Souza
    Bioorganic & Medicinal Chemistry.2021; 46: 116340.     CrossRef
  • Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer
    Alex Martinez-Marti, Enriqueta Felip, Francesco Mattia Mancuso, Ginevra Caratú, Judit Matito, Paolo Nuciforo, Irene Sansano, Nely Diaz-Mejia, Susana Cedrés, Ana Callejo, Patricia Iranzo, Nuria Pardo, Josep Maria Miquel, Alejandro Navarro, Ana Vivancos, Mi
    British Journal of Cancer.2021; 125(11): 1561.     CrossRef
  • A Biparatopic Antibody–Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade
    John O. DaSilva, Katie Yang, Oliver Surriga, Thomas Nittoli, Arthur Kunz, Matthew C. Franklin, Frank J. Delfino, Shu Mao, Feng Zhao, Jason T. Giurleo, Marcus P. Kelly, Sosina Makonnen, Carlos Hickey, Pamela Krueger, Randi Foster, Zhaoyuan Chen, Marc W. Re
    Molecular Cancer Therapeutics.2021; 20(10): 1966.     CrossRef
  • Development and full validation of an LC–MS/MS methodology to quantify capmatinib (INC280) following intragastric administration to rats
    Xiaoguang Fan, Guanghu Yang, Wenjuan Cui, Qin Liu, Zhaolong Zhang, Zhikun Zhang
    Biomedical Chromatography.2020;[Epub]     CrossRef
  • A Randomized-Controlled Phase 2 Study of the MET Antibody Emibetuzumab in Combination with Erlotinib as First-Line Treatment for EGFR Mutation–Positive NSCLC Patients
    Giorgio Scagliotti, Denis Moro-Sibilot, Jens Kollmeier, Adolfo Favaretto, Eun Kyung Cho, Heidrun Grosch, Martin Kimmich, Nicolas Girard, Chun-Ming Tsai, Te-Chun Hsia, Matteo Brighenti, Christian Schumann, Xuejing Aimee Wang, Sameera R. Wijayawardana, Aaro
    Journal of Thoracic Oncology.2020; 15(1): 80.     CrossRef
  • Targeted Therapy and Checkpoint Immunotherapy in Lung Cancer
    Roberto Ruiz-Cordero, Walter Patrick Devine
    Surgical Pathology Clinics.2020; 13(1): 17.     CrossRef
  • Meta-analysis of functional expression and mutational analysis of c-Met in various cancers
    Murugesan Sivakumar, Murugesan Jayakumar, Palaniappan Seedevi, Palaniappan Sivasankar, Muthu Ravikumar, Sundharaiyya Surendar, Tamilselvi Murugan, Shahid S. Siddiqui, Sivakumar Loganathan
    Current Problems in Cancer.2020; 44(4): 100515.     CrossRef
  • Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement
    Xing Huang, Enliang Li, Hang Shen, Xun Wang, Tianyu Tang, Xiaozhen Zhang, Jian Xu, Zengwei Tang, Chengxiang Guo, Xueli Bai, Tingbo Liang
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Statins use and its impact in EGFR‐TKIs resistance to prolong the survival of lung cancer patients: A Cancer registry cohort study in Taiwan
    Phung‐Anh Nguyen, Chih‐Cheng Chang, Cooper J. Galvin, Yao‐Chin Wang, Soo Yeon An, Chih‐Wei Huang, Yu‐Hsiang Wang, Min‐Huei Hsu, Yu‐Chuan (Jack) Li, Hsuan‐Chia Yang
    Cancer Science.2020; 111(8): 2965.     CrossRef
  • A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells
    Kenneth J. Finn, Scott E. Martin, Jeff Settleman
    Cancer Research.2020; 80(1): 79.     CrossRef
  • Emerging therapies for non-small cell lung cancer
    Chao Zhang, Natasha B. Leighl, Yi-Long Wu, Wen-Zhao Zhong
    Journal of Hematology & Oncology.2019;[Epub]     CrossRef
  • Capmatinib for the treatment of non-small cell lung cancer
    Johan Filip Vansteenkiste, Charlotte Van De Kerkhove, Els Wauters, Pierre Van Mol
    Expert Review of Anticancer Therapy.2019; 19(8): 659.     CrossRef
  • Afatinib Overcomes Pemetrexed-Acquired Resistance in Non-Small Cell Lung Cancer Cells Harboring an EML4-ALK Rearrangement
    Ji-Hyun Kwon, Kui-Jin Kim, Ji Hea Sung, Koung Jin Suh, Ji Yun Lee, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Soyeon Kim, Sung-Soo Yoon, Jong Seok Lee
    Cells.2019; 8(12): 1538.     CrossRef
  • DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild‐type NSCLC cells to AZD9291
    Yang‐ling Li, Ke Ding, Xiu Hu, Lin‐wen Wu, Dong‐mei Zhou, Ming‐jun Rao, Neng‐ming Lin, Chong Zhang
    Journal of Cellular and Molecular Medicine.2019; 23(11): 7427.     CrossRef
  • MiR-1246 Promotes Metastasis and Invasion of A549 cells by Targeting GSK-3β‒Mediated Wnt/β-Catenin Pathway
    Fan Yang, Hairong Xiong, Li Duan, Qian Li, Xin Li, Yongqin Zhou
    Cancer Research and Treatment.2019; 51(4): 1420.     CrossRef
  • 12,381 View
  • 572 Download
  • 44 Web of Science
  • 43 Crossref
Close layer
Clinical Implications of VEGF, TGF-beta1, and IL-1beta in Patients with Advanced Non-small Cell Lung Cancer
Ji-Won Kim, Youngil Koh, Dong-Wan Kim, Yong-Oon Ahn, Tae Min Kim, Sae-Won Han, Do-Youn Oh, Se-Hoon Lee, Seock-Ah Im, Tae-You Kim, Dae Seog Heo, Yung-Jue Bang
Cancer Res Treat. 2013;45(4):325-333.   Published online December 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.4.325
AbstractAbstract PDFPubReaderePub
PURPOSE
Vascular endothelial growth factor (VEGF)-A, VEGF165b, interleukin (IL)-1beta, and transforming growth factor (TGF)-beta1 are known to influence tumor angiogenesis. Clinical implications of these cytokines need to be elucidated.
MATERIALS AND METHODS
Using clinical data and baseline serum samples of 140 consecutive patients with advanced non-small cell lung cancer who received platinum-based combination chemotherapy, we investigated the association among serum cytokine levels, treatment outcomes, as well as leukocyte and platelet counts.
RESULTS
The median age of patients was 64 years (range, 26 to 86 years). The male to female ratio was 104:36. High TGF-beta1 and IL-1beta levels were associated with shorter progression-free survival, and high VEGF-A and IL-1beta levels were associated with shorter overall survival in the univariate analysis. VEGF165b was not related to the treatment outcomes. Leukocytosis and thrombocytosis were associated with shorter overall survival. The multivariate analysis demonstrated that VEGF-A, IL-1beta, and leukocytosis were significant prognostic factors (p=0.0497, p=0.047, and p<0.001, respectively). Leukocytosis was not associated with recent pneumonia (p=0.937) and correlated with VEGF-A (p<0.001) and TGF-beta1 (p=0.020) levels.
CONCLUSION
Serum VEGF-A, TGF-1beta, and IL-1beta levels, in addition to leukocyte and platelet counts, are shown to be associated with clinical outcomes. Leukocyte and platelet counts are correlated with serum VEGF-A and TGF-beta1 levels.

Citations

Citations to this article as recorded by  
  • Canakinumab Versus Placebo in Combination With First-Line Pembrolizumab Plus Chemotherapy for Advanced Non–Small-Cell Lung Cancer: Results From the CANOPY-1 Trial
    Daniel S.W. Tan, Enriqueta Felip, Gilberto de Castro, Benjamin J. Solomon, Alastair Greystoke, Byoung Chul Cho, Manuel Cobo, Tae Min Kim, Sandip Ganguly, Enric Carcereny, Luis Paz-Ares, Jaafar Bennouna, Marina Chiara Garassino, Michael Schenker, Sang-We K
    Journal of Clinical Oncology.2024; 42(2): 192.     CrossRef
  • Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 t
    Luis Paz-Ares, Yasushi Goto, Darren Wan-Teck Lim, Balazs Halmos, Byoung Chul Cho, Manuel Cobo, José Luis González Larriba, Caicun Zhou, Ingel Demedts, Akin Atmaca, Sofia Baka, Bijoyesh Mookerjee, Socorro Portella, Zewen Zhu, Jincheng Wu, David Demanse, Bh
    Lung Cancer.2024; 189: 107451.     CrossRef
  • Targeting Notch-Driven Cytokine Secretion: Novel Therapies for Triple Negative Breast Cancer
    Wanda Marini, Brooke E. Wilson, Michael Reedijk
    DNA and Cell Biology.2023; 42(2): 73.     CrossRef
  • IL-1β is involved in docetaxel chemoresistance by regulating the formation of polyploid giant cancer cells in non-small cell lung cancer
    Song Zhao, Sining Xing, Lili Wang, Mingyue Ouyang, Shuo Liu, Lingyan Sun, Huiying Yu
    Scientific Reports.2023;[Epub]     CrossRef
  • Prognostic Implications of Pyroptosis-Related Gene Signatures in Lung Squamous Cell Carcinoma
    Tingting Li, Huanqing Liu, Chunsheng Dong, Jun Lyu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses
    Mélanie Bruchard, Mannon Geindreau, Anaïs Perrichet, Caroline Truntzer, Elise Ballot, Romain Boidot, Cindy Racoeur, Emilie Barsac, Fanny Chalmin, Christophe Hibos, Thomas Baranek, Christophe Paget, Bernhard Ryffel, Cédric Rébé, Catherine Paul, Frédérique
    Nature Immunology.2022; 23(2): 262.     CrossRef
  • Targeting interleukin-1β and inflammation in lung cancer
    Jun Zhang, Nirmal Veeramachaneni
    Biomarker Research.2022;[Epub]     CrossRef
  • Immunohistochemical Detection of Pro-Inflammatory and Anti-Inflammatory Interleukins in the Lungs of Sheep with Jaagsiekte
    Emin KARAKURT, Enver BEYTUT, Serpil DAĞ, Hilmi NUHOĞLU, Ayfer YILDIZ, Emre KURTBAŞ
    Turkish Journal of Veterinary Research.2022; 6(1): 9.     CrossRef
  • Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System
    Ana Belén Herrera-Campos, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Mónica Fernández-Cortés, Luis M. Montuenga, F. Javier Oliver, Angel Garcia-Diaz
    Cancers.2022; 14(11): 2740.     CrossRef
  • Repositioning canakinumab for non-small cell lung cancer—important lessons for drug repurposing in oncology
    Mark P. Lythgoe, Vinay Prasad
    British Journal of Cancer.2022; 127(5): 785.     CrossRef
  • Promotion of angiogenesis in vitro by Astragalus polysaccharide via activation of TLR4 signaling pathway
    Huiqing Qiu, Liyan Zhang, Xinqi He, Yusen Wei, Miaoran Wang, Bin Ma, Dailun Hu, Zhongli Shi
    Journal of Food Biochemistry.2022;[Epub]     CrossRef
  • B Cell Receptor Signaling Pathway Mutation as Prognosis Predictor of Immune Checkpoint Inhibitors in Lung Adenocarcinoma by Bioinformatic Analysis
    Anqi Lin, Jianbo Fang, Quan Cheng, Zaoqu Liu, Peng Luo, Jian Zhang
    Journal of Inflammation Research.2022; Volume 15: 5541.     CrossRef
  • Biological Rationale for Peripheral Blood Cell–Derived Inflammatory Indices and Related Prognostic Scores in Patients with Advanced Non-Small-Cell Lung Cancer
    Giuseppe Luigi Banna, Alex Friedlaender, Marco Tagliamento, Veronica Mollica, Alessio Cortellini, Sara Elena Rebuzzi, Arsela Prelaj, Abdul Rafeh Naqash, Edouard Auclin, Lucia Garetto, Laura Mezquita, Alfredo Addeo
    Current Oncology Reports.2022; 24(12): 1851.     CrossRef
  • IL-1β enhances cell viability and decreases 5-FU sensitivity in novel colon cancer cell lines derived from African American patients
    Marzia Spagnardi, Jenny Paredes, Jovanny Zabaleta, Jone Garai, Tiana Reyes, Laura A. Martello, Jennie L. Williams
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Immune Resistance in Lung Adenocarcinoma
    Magda Spella, Georgios T. Stathopoulos
    Cancers.2021; 13(3): 384.     CrossRef
  • The Role of Tumor Inflammatory Microenvironment in Lung Cancer
    Zhaofeng Tan, Haibin Xue, Yuli Sun, Chuanlong Zhang, Yonglei Song, Yuanfu Qi
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Interleukin-1β and Cancer
    Cédric Rébé, François Ghiringhelli
    Cancers.2020; 12(7): 1791.     CrossRef
  • Immune Cells Combined With NLRP3 Inflammasome Inhibitor Exert Better Antitumor Effect on Pancreatic Ductal Adenocarcinoma
    Hailiang Liu, Yong Xu, Kai Liang, Rong Liu
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients
    Michela Terlizzi, Chiara Colarusso, Ilaria De Rosa, Pasquale Somma, Carlo Curcio, Rita P. Aquino, Luigi Panico, Rosario Salvi, Federica Zito Marino, Gerardo Botti, Aldo Pinto, Rosalinda Sorrentino
    Journal of Experimental & Clinical Cancer Research.2020;[Epub]     CrossRef
  • A review of canakinumab and its therapeutic potential for non-small cell lung cancer
    Kara M. Schenk, Joshua E. Reuss, Karin Choquette, Alexander I. Spira
    Anti-Cancer Drugs.2019; 30(9): 879.     CrossRef
  • Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity
    Zachary T. Morrow, Zachary M. Powers, John-Demian Sauer
    Current Clinical Microbiology Reports.2019; 6(4): 213.     CrossRef
  • Cell Death, Inflammation, Tumor Burden, and Proliferation Blood Biomarkers Predict Lung Cancer Radiotherapy Response and Correlate With Tumor Volume and Proliferation Imaging
    Ahmed Salem, Hitesh Mistry, Alison Backen, Clare Hodgson, Pek Koh, Emma Dean, Lynsey Priest, Kate Haslett, Ioannis Trigonis, Alan Jackson, Marie-Claude Asselin, Caroline Dive, Andrew Renehan, Corinne Faivre-Finn, Fiona Blackhall
    Clinical Lung Cancer.2018; 19(3): 239.     CrossRef
  • Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3′-Diindolylmethane
    Thomas Wang, Quynhchi Pham, Young Kim
    International Journal of Molecular Sciences.2018; 19(2): 339.     CrossRef
  • IL‐1β promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem‐like properties through PI3K pathway
    Aiwen Yu, Yu Wang, Yue Bian, Lisha Chen, Junfu Guo, Wei Shen, Danqi Chen, Shanshan Liu, Xiuju Sun
    Journal of Cellular Biochemistry.2018; 119(10): 8163.     CrossRef
  • SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients
    Camille Emprou, Pauline Le Van Quyen, Jérémie Jégu, Nathalie Prim, Noëlle Weingertner, Eric Guérin, Erwan Pencreach, Michèle Legrain, Anne‐Claire Voegeli, Charlotte Leduc, Bertrand Mennecier, Pierre‐Emmanuel Falcoz, Anne Olland, Nicolas Santelmo, Elisabet
    Cancer Medicine.2018; 7(7): 3278.     CrossRef
  • RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms
    Stephen Bridgett, Margaret Dellett, David A. Simpson
    Scientific Reports.2017;[Epub]     CrossRef
  • Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation
    Jing Yang, Yun-zhou Li, Phillip B. Hylemon, Lu-yong Zhang, Hui-ping Zhou
    Biomedicine & Pharmacotherapy.2017; 95: 1777.     CrossRef
  • Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Poor Prognosis in Small-cell Lung Cancer
    Xu Wang, Min Liu, Lei Zhang, Kewei Ma
    Archives of Medical Research.2016; 47(1): 19.     CrossRef
  • Prediction of survival and tumor recurrence in patients undergoing surgery for pancreatic neuroendocrine neoplasms
    Alexander Kaltenborn, Svenja Matzke, Moritz Kleine, Till Krech, Wolf Ramackers, Florian W. R. Vondran, Jürgen Klempnauer, Hüseyin Bektas, Harald Schrem
    Journal of Surgical Oncology.2016; 113(2): 194.     CrossRef
  • Association of CT perfusion imaging with plasma levels of TGF-β1 and VEGF in patients with NSCLC
    Da-Wei Li, Bao-Zhong Wu, Yu-Sen Shi, Zhi-Qun Li, Xu-Dong Liu, Xiao-Hua Li
    Asian Pacific Journal of Tropical Medicine.2016; 9(2): 177.     CrossRef
  • Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model
    Anne-Marie Baird, Steven G. Gray, Derek J. Richard, Kenneth J. O’Byrne
    Scientific Reports.2016;[Epub]     CrossRef
  • Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity
    Kristian Hargadon
    Journal of Clinical Medicine.2016; 5(9): 76.     CrossRef
  • Associations of Circulating Cytokines and Chemokines With Cancer Mortality in Men With Rheumatoid Arthritis
    Bryant R. England, Jeremy Sokolove, William H. Robinson, Geoffrey M. Thiele, Apar K. Ganti, Harlan Sayles, Kaleb Michaud, Liron Caplan, Lisa A. Davis, Grant W. Cannon, Brian Sauer, Namrata Singh, E. Blair Solow, Andreas M. Reimold, Gail S. Kerr, Pascale S
    Arthritis & Rheumatology.2016; 68(10): 2394.     CrossRef
  • The inflammasome: an emerging therapeutic oncotarget for cancer prevention
    Wang Zhiyu, Neng Wang, Qi Wang, Cheng Peng, Jin Zhang, Pengxi Liu, Aihua Ou, Shaowen Zhong, Mario D. Cordero, Yi Lin
    Oncotarget.2016; 7(31): 50766.     CrossRef
  • Elevated chronic inflammatory factors and myeloid‐derived suppressor cells indicate poor prognosis in advanced melanoma patients
    Huanhuan Jiang, Christoffer Gebhardt, Ludmila Umansky, Philipp Beckhove, Torsten J. Schulze, Jochen Utikal, Viktor Umansky
    International Journal of Cancer.2015; 136(10): 2352.     CrossRef
  • The Clinical Research of Serum VEGF, TGF-β1, and Endostatin in Non-small Cell Lung Cancer
    Shu-Guang Liu, Shuang-Hu Yuan, Hui-Yong Wu, Jie Liu, Cheng-Suo Huang
    Cell Biochemistry and Biophysics.2015; 72(1): 165.     CrossRef
  • Platelet VEGF and serum TGF-β1 levels predict chemotherapy response in non-small cell lung cancer patients
    Bao-Hong Fu, Zhan-Zhao Fu, Wei Meng, Tao Gu, Xiao-Dong Sun, Zhi Zhang
    Tumor Biology.2015; 36(8): 6477.     CrossRef
  • Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy
    Morena Fasano, Carminia Maria Della Corte, Federica Papaccio, Fortunato Ciardiello, Floriana Morgillo
    Journal of Thoracic Oncology.2015; 10(8): 1133.     CrossRef
  • The angiogenic responses induced by release of angiogenic proteins from tumor cell‐activated platelets are regulated by distinct molecular pathways
    Hongyan Wu, Fangtian Fan, Zhaoguo Liu, Feng Zhang, Yuping Liu, Zhonghong Wei, Cunsi Shen, Yuzhu Cao, Aiyun Wang, Yin Lu
    IUBMB Life.2015; 67(8): 626.     CrossRef
  • Serum Calprotectin, CD26 and EGF to Establish a Panel for the Diagnosis of Lung Cancer
    Sonia Blanco-Prieto, Lorena Vázquez-Iglesias, Mar Rodríguez-Girondo, Leticia Barcia-Castro, Alberto Fernández-Villar, María Isabel Botana-Rial, Francisco Javier Rodríguez-Berrocal, María Páez de la Cadena, Rossella Rota
    PLOS ONE.2015; 10(5): e0127318.     CrossRef
  • 14,199 View
  • 104 Download
  • 47 Web of Science
  • 40 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP