Cancer Research and Treatment

Original Articles

Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion Weighted Imaging in Evaluating the Radio-sensitivity of Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiation Therapy: Youping Xiao, Ying Chen, Yunbin Chen, Zhuangzhen He, Yiqi Yao, Jianji Pan; Cancer Res Treat. 2019;51(1):345-356. Published online May 14, 2018; DOI: https://doi.org/10.4143/crt.2018.089

Purpose
Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI)was evaluated regarding its ability to preliminarily predict the short-term treatment response of nasopharyngeal carcinoma (NPC) following intensity-modulated radiation therapy.
Materials and Methods
IVIM-DWI with 14 b-factors (0-1,000 sec/mm2 ) was performed with a 3T MR system on 47 consecutive NPCs before, during (end of the 5th, 10th, 15th, 20th, and 25th fractions), and after fractional radiotherapy. IVIM parametrics (D, f, and D*) were calculated and compared to the baseline and xth fraction. Patients were categorized into responders and non-responders after radiotherapy. IVIM parametrics were also compared between subgroups.
Results
After fractional radiations, the D (except D5 and D at the end of the 5th fraction) after radiations were larger than the baseline D0 (p < 0.05), and the post-radiation D* (except D*5 and D*10) were smaller than D*0 (p < 0.05). f0 was smaller than f5 and f10 (p < 0.001) but larger than fend (p < 0.05). Furthermore, greater D5, D10, D15, and f10 coupled with smaller f0, D*20, and D*25were observed in responders than non-responders (all p < 0.01). Responders also presented larger ΔD10, Δf10, ΔD*20, and δD*20 than non-responders (p < 0.05). Receiver operating characteristic curve analysis indicated that the D5, D*20, and f10 could better differentiate responders from non-responders.
Conclusion
IVIM-DWI could efficiently assess tumor treatment response to fractional radiotherapy and predict the radio-sensitivity for NPCs.

Citations

Citations to this article as recorded by

Intravoxel incoherent motion magnetic resonance imaging to assess early tumor response to radiation therapy: Review and future directions
Emmanuel Mesny, Benjamin Leporq, Olivier Chapet, Olivier Beuf
Magnetic Resonance Imaging.2024; 108: 129. CrossRef
Prediction of short-term treatment outcome of nasopharyngeal carcinoma based on voxel incoherent motion imaging and arterial spin labeling quantitative parameters
Liping Liao, Teng Liu, Bo Wei
European Journal of Radiology Open.2023; 10: 100466. CrossRef
A review of diffusion-weighted magnetic resonance imaging in head and neck cancer patients for treatment evaluation and prediction of radiation-induced xerostomia
Tai Ermongkonchai, Richard Khor, Morikatsu Wada, Eddie Lau, Daniel Tao Xing, Sweet Ping Ng
Radiation Oncology.2023;[Epub] CrossRef
Intravoxel incoherent motion radiomics nomogram for predicting tumor treatment responses in nasopharyngeal carcinoma
Yihao Guo, Ganmian Dai, Xiaoli Xiong, Xiaoyi Wang, Huijuan Chen, Xiaoyue Zhou, Weiyuan Huang, Feng Chen
Translational Oncology.2023; 31: 101648. CrossRef
Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI
Wenguang Liu, Xiao Wang, Simin Xie, Weiyin Vivian Liu, Ismail Bilal Masokano, Yu Bai, Juan Chen, Linhui Zhong, Yijing Luo, Gaofeng Zhou, Wenzheng Li, Yigang Pei
Cancer Imaging.2023;[Epub] CrossRef
Baseline Amide Proton Transfer Imaging at 3T Fails to Predict Early Response to Induction Chemotherapy in Nasopharyngeal Carcinoma
Zhou Liu, Liyan Zou, Qian Yang, Long Qian, Tianran Li, Honghong Luo, Canwen Che, Yuanyuan Lei, Peng Chen, Chunyan Qiu, Xin Liu, Yin Wu, Dehong Luo
Frontiers in Oncology.2022;[Epub] CrossRef
Arterial spin labeling of nasopharyngeal carcinoma shows early therapy response
Jun Liu, Juan Zhu, Yaxian Wang, Fei Wang, Hualin Yang, Nan Wang, Qingyun Chu, Qing Yang
Insights into Imaging.2022;[Epub] CrossRef
A comparative study of functional MRI in predicting response of regional nodes to induction chemotherapy in patients with nasopharyngeal carcinoma
Dawei Zhao, Xuemei Fang, Wenjun Fan, Lingling Meng, Yanrong Luo, Nanxiang Chen, Jinfeng Li, Xiao Zang, Meng Li, Xingdong Guo, Biyang Cao, Chenchen Wu, Xin Tan, Boning Cai, Lin Ma
Frontiers in Oncology.2022;[Epub] CrossRef
The value of intravoxel incoherent motion model-based diffusion-weighted imaging for predicting long-term outcomes in nasopharyngeal carcinoma
Yuhui Qin, Chen Chen, Haotian Chen, Fabao Gao
Frontiers in Oncology.2022;[Epub] CrossRef
Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects
Song Yang, Gaohua Han, Quan Chen, Lei Yu, Peng Wang, Qi Zhang, Jiang Dong, Wei Zhang, Junxing Huang
International Journal of Nanomedicine.2021; Volume 16: 239. CrossRef
Diffusion-weighted MRI for predicting treatment response in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis
Min Kyoung Lee, Yangsean Choi, So-Lyung Jung
Scientific Reports.2021;[Epub] CrossRef
Application Value of Magnetic Resonance Radiomics and Clinical Nomograms in Evaluating the Sensitivity of Neoadjuvant Chemotherapy for Nasopharyngeal Carcinoma
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Frontiers in Oncology.2021;[Epub] CrossRef
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Cancer Imaging.2021;[Epub] CrossRef
Early detection treatment response for head and neck carcinomas using intravoxel incoherent motion-magnetic resonance imaging: a meta-analysis
Qingxu Song, Fang Li, Xin Chen, Jianbo Wang, Hong Liu, Yufeng Cheng
Dentomaxillofacial Radiology.2020; : 20190507. CrossRef
Pre-treatment intravoxel incoherent motion diffusion-weighted imaging predicts treatment outcome in nasopharyngeal carcinoma
Sahrish Qamar, Ann D. King, Qi-Yong H. Ai, Tiffany Y. So, Frankie Kwok Fai Mo, Weitian Chen, Darren M.C. Poon, Macy Tong, Brigette B. Ma, Edwin P. Hui, David Ka-Wai Yeung, Yi-Xiang Wang, Jing Yuan
European Journal of Radiology.2020; 129: 109127. CrossRef
Advanced magnetic resonance imaging techniques for tumors of the head and neck
E. Santos Armentia, T. Martín Noguerol, V. Suárez Vega
Radiología (English Edition).2019; 61(3): 191. CrossRef

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Phase I Study of Axitinib in Combination with Cisplatin and Capecitabine in Patients with Previously Untreated Advanced Gastric Cancer: Do-Youn Oh, Toshihiko Doi, Kuniaki Shirao, Keun-Wook Lee, Sook Ryun Park, Ying Chen, Liqiang Yang, Olga Valota, Yung-Jue Bang; Cancer Res Treat. 2015;47(4):687-696. Published online February 12, 2015; DOI: https://doi.org/10.4143/crt.2014.225

Abstract PDF PubReader ePub

Purpose
This phase I trial evaluated the question of whether the standard starting dose of axitinib could be administered in combination with therapeutic doses of cisplatin/capecitabine in patients with previously untreated advanced gastric cancer, and assessed overall safety, pharmacokinetics, and preliminary antitumor activity of this combination.
Materials and Methods
Patients in dose level (DL) 1 received axitinib 5 mg twice a day (days 1 to 21) with cisplatin 80 mg/m2 (day 1) and capecitabine 1,000 mg/m2 twice a day (days 1 to 14) in 21-day cycles. Maximum tolerated dose (MTD) was the highest dose at which ≤ 30% of the first 12 patients experienced a dose-limiting toxicity (DLT) during cycle 1. Ten additional patients were enrolled and treated at the MTD in order to obtain additional safety and pharmacokinetic data.
Results
Three DLTs occurred during cycle 1 in three (25%) of the first 12 patients: ruptured abdominal aortic aneurysm, acute renal failure, and > 5 consecutive days of missed axitinib due to thrombocytopenia. DL1 was established as the MTD, since higher DL cohorts were not planned. Common grade 3/4 non-hematologic adverse events in 22 patients treated at DL1 included hypertension (36.4%) and decreased appetite and stomatitis (18.2% each). Cisplatin/capecitabine slightly increased axitinib exposure; axitinib decreased capecitabine and 5-fluorouracil exposure. Eight patients (36.4%) each had partial response or stable disease. Median response duration was 9.1 months; median progression-free survival was 3.8 months.
Conclusion
In patients with advanced gastric cancer, standard doses of axitinib plus therapeutic doses of cisplatin and capecitabine could be administered in combination. Adverse events were manageable.

Citations

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Frontiers in Immunology.2023;[Epub] CrossRef
Early TP53 Alterations Shape Gastric and Esophageal Cancer Development
Pranshu Sahgal, Brandon M. Huffman, Deepa T. Patil, Walid K. Chatila, Rona Yaeger, James M. Cleary, Nilay S. Sethi
Cancers.2021; 13(23): 5915. CrossRef
High ELK3 Expression is Associated with the VEGF-C/VEGFR-3 Axis and Gastric Tumorigenesis and Enhances Infiltration of M2 Macrophages
Wang Dazhi, Jiao Zheng, Ren Chunling
Future Medicinal Chemistry.2020; 12(24): 2209. CrossRef
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International Journal of Biological Macromolecules.2019; 123: 1106. CrossRef
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Lin Yang, Yanan Yu, Qi Zhang, Xiaoyu Li, Cuiping Zhang, Tao Mao, Siliang Liu, Zibin Tian
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Li-Tzong Chen, Do-Youn Oh, Min-Hee Ryu, Kun-Huei Yeh, Winnie Yeo, Roberto Carlesi, Rebecca Cheng, Jongseok Kim, Mauro Orlando, Yoon-Koo Kang
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