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Original Articles
Immunogenicity of Influenza Vaccine in Colorectal Cancer Patients
Dong Ho Kim, Yun Yong Lee, Ui Sup Shin, Sun Mi Moon
Cancer Res Treat. 2013;45(4):303-312.   Published online December 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.4.303
AbstractAbstract PDFPubReaderePub
PURPOSE
Although influenza is regarded as a major cause of morbidity and mortality in immunocompromised patients, vaccine coverage remains poor. We evaluated the immunogenicity of influenza vaccines in colorectal cancer patients.
MATERIALS AND METHODS
In this study, 40 colorectal cancer patients who received an influenza vaccine at the Korea Cancer Center Hospital during the 2009-2010 and 2010-2011 influenza seasons were analyzed. The blood samples were collected at prevaccination and 30 days post vaccination, and antibody titers were measured using the hemagglutination-inhibition tests.
RESULTS
In the 2009-2011 season, the seroprotection rate for H1N1 (94.7%) was significantly higher than that for H3N2 (42.1%) and B (47.3%). The seroconversion rate was 52.6%, 26.3%, and 36.8% for H1N1, H3N2, and B, respectively. Fold increase of geometric mean titer (MFI) was 3.86, 1.49, and 3.33 for H1N1, H3N2, and B, respectively. In the 2010-2011 season, the seroprotection rate for H1N1 (57.1%) was significantly higher than that for H3N2 (52.4%) and B (38.1%). The seroconversion rate was 52.4%, 47.6% and 33.3% for H1N1, H3N2, and B, respectively. MFI was 12.29, 3.62 and 4.27 for H1N1, H3N2, and B, respectively.
CONCLUSION
Our study cohort showed an acceptable immune response to an influenza vaccine without significant adverse effects, supporting the recommendation for annual influenza vaccination in colorectal cancer patients.

Citations

Citations to this article as recorded by  
  • Therapeutic vaccines for colorectal cancer: The progress and future prospect
    Mina Shahnazari, Pouria Samadi, Mona Pourjafar, Akram Jalali
    International Immunopharmacology.2020; 88: 106944.     CrossRef
  • Vaccines for colorectal cancer: an update
    Mostafa Sarvizadeh, Faezeh Ghasemi, Fatemeh Tavakoli, Sara Sadat Khatami, Ebrahim Razi, Hossein Sharifi, Nousin Moussavi Biouki, Mohsen Taghizadeh
    Journal of Cellular Biochemistry.2019; 120(6): 8815.     CrossRef
  • Quadrivalent Influenza Vaccine-Induced Antibody Response and Influencing Determinants in Patients ≥ 55 Years of Age in the 2018/2019 Season
    Maria Ganczak, Paulina Dubiel, Marzena Drozd-Dąbrowska, Ewelina Hallmann-Szelińska, Karol Szymański, Lidia B. Brydak
    International Journal of Environmental Research and Public Health.2019; 16(22): 4489.     CrossRef
  • Immunogenicity of Influenza Vaccination in Patients With Cancer
    Saiama N. Waqar, Leigh Boehmer, Daniel Morgensztern, Andrea Wang-Gillam, Steven Sorscher, Steven Lawrence, Feng Gao, Kalin Guebert, Kristina Williams, Ramaswamy Govindan
    American Journal of Clinical Oncology.2018; 41(3): 248.     CrossRef
  • Immunogenicity of trivalent influenza vaccine in patients with lung cancer undergoing anticancer chemotherapy
    Kei Nakashima, Masahiro Aoshima, Satoko Ohfuji, Kanzo Suzuki, Masahiro Katsurada, Naoko Katsurada, Masafumi Misawa, Yoshihito Otsuka, Kyoko Kondo, Yoshio Hirota
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  • Influenza vaccination in adult patients with solid tumours treated with chemotherapy
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    European Journal of Cancer.2017; 76: 134.     CrossRef
  • Vaccination in Patients with Primary Immune Deficiency, Secondary Immune Deficiency and Autoimmunity with Immune Regulatory Abnormalities
    Martha M Eibl, Hermann M Wolf
    Immunotherapy.2015; 7(12): 1273.     CrossRef
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Clinicopathologic Characteristics, Surgical Treatment and Outcomes for Splenic Flexure Colon Cancer
Chan Wook Kim, Ui Sup Shin, Chang Sik Yu, Jin Cheon Kim
Cancer Res Treat. 2010;42(2):69-76.   Published online June 30, 2010
DOI: https://doi.org/10.4143/crt.2010.42.2.69
AbstractAbstract PDFPubReaderePub
Purpose

This current study examined the clinicopathologic characteristics of patients with splenic flexure (SF) colon cancer and the association with the surgical outcomes to find the optimal procedure to treat this malady.

Materials and Methods

A total of 167 operated patients with SF colon cancer were consecutively recruited between 1993 and 2003. The clinicopathological, operative and survival data was reviewed and analyzed.

Results

For the SF colon cancer patients, the proportion of males was higher than that for the right-sided colon patients or the sigmoid-descending junction & sigmoid (SD & S) colon patients (p≤0.05, respectively) and the age at the time of diagnosis was younger (p≤0.05). Obstruction was more frequent in the patients with SF colon cancer than that for the patients with colon cancer at other sites (p≤0.001). The incidence of mucinous adenocarcinoma for the SF patients was similar to that for the patients with right-sided colon cancer, but it was higher than that for the patients with SD & S colon cancer (11.4% vs. 6.5%, p=0.248 or 2.5%, respectively, p=0.001). Disease-free and overall survival did not differ between the patients who underwent a left hemicolectomy and extended surgery such as combined splenectomy or subtotal colectomy. Multivariate analysis showed that old age (≥60 years) and a N1-2 and M1 status were the independent risk factors for overall survival.

Conclusion

The SF colon cancers exhibited exclusively different characteristics as compared to colon cancers at other site colon cancers. It appears that left hemicolectomy was generally sufficient for a satisfactory oncological outcome, obviating concurrent splenectomy.

Citations

Citations to this article as recorded by  
  • Surgical approach to splenic flexure adenocarcinoma of the colon: Less is more?
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    Colorectal Disease.2024; 26(7): 1485.     CrossRef
  • Extended procedure has no oncological benefits over segmental resection in the treatment of non-metastatic splenic flexure colon cancer, a population-based cohort study and a single center’s decade-long experience
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    Updates in Surgery.2024; 76(4): 1289.     CrossRef
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    Julia F. Kohn, Sonja Boatman, Qi Wang, Schelomo Marmor, Imran Hassan, Robert D. Madoff, Wolfgang B. Gaertner, Paolo Goffredo
    Colorectal Disease.2024; 26(11): 1883.     CrossRef
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    Chi Zhang, Esteban Calderon, Yu Hui Chang, Ga-ram Han, Scott R. Kelley, Amit Merchea, Justin T. Brady, Tonia M. Young-Fadok, David A. Etzioni, Nitin Mishra
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    Hefei Cheng, Minjian Zhou, Lianlei Yang, Ziqi Sui
    Medicine.2023; 102(19): e33742.     CrossRef
  • Standardization of the Definition and Surgical Management of the Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?
    Cigdem Benlice, Amjad Parvaiz, Bilgi Baca, Werner Hohenberger, Danilo Miskovic, Luca Stocchi, Scott Steele, Seon-Hahn Kim, Torbjörn Holm, Antonino Spinelli, Ismail Gogenur, Yves Panis, Hirotoshi Hasegawa, Alexey Karachun, Juan C Patron Uriburu, Masaki Ito
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    Kazuki Ueda, Koji Daito, Hokuto Ushijima, Yoshinori Yane, Yasumasa Yoshioka, Tadao Tokoro, Masayoshi Iwamoto, Toshiaki Wada, Yusuke Makutani, Junichiro Kawamura
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    Corrado Pedrazzani, Giulia Turri, Soo Yeun Park, Koya Hida, Yudai Fukui, Jacopo Crippa, Giovanni Ferrari, Matteo Origi, Gaya Spolverato, Matteo Zuin, Sung Uk Bae, Seong Kyu Baek, Andrea Costanzi, Dario Maggioni, Gyung Mo Son, Andrea Scala, Timothy Rockall
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    Gilles Manceau, Arnaud Alves, Hélène Meillat, Léonor Benhaïm, Mehdi Ouaïssi, Yves H. Panis, Jean-Jacques Tuech, Bertrand Dousset, Cécile Brigand, Eddy Cotte, Zaher Lakkis, Bogdan Badic, Frédéric Marchal, Charles Sabbagh, Momar Diouf, Mehdi Karoui
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    International Journal of Colorectal Disease.2022; 37(4): 757.     CrossRef
  • Surgical Treatment of SplenicFlexure Colon Cancer: Analysisof Short-Term and Long-Term Outcomes of Three DifferentSurgical Procedures
    Mingjin Huang, Xiaojie Wang, Yu Shao, Shenghui Huang, Ying Huang, Pan Chi
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Extended right colectomy, left colectomy, or segmental left colectomy for splenic flexure carcinomas: a European multicenter propensity score matching analysis
    Nicola de’Angelis, Aleix Martínez-Pérez, Des C. Winter, Filippo Landi, Giulio Cesare Vitali, Bertrand Le Roy, Federico Coccolini, Francesco Brunetti, Valerio Celentano, Salomone Di Saverio, Frederic Ris, David Fuks, Eloy Espin
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    Stefan Morarasu, Cillian Clancy, Catherine T Cronin, Takeru Matsuda, Helen M Heneghan, Desmond C Winter
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  • Laparoscopic Colectomy for Splenic Flexure Cancer Approached from Four Directions
    Hiroki Hashida, Masato Kondo, Ryosuke Kita, Koji Kitamura, Kenji Uryuhara, Hiroyuki Kobayashi, Satoshi Kaihara
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(9): 1014.     CrossRef
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    International Cancer Conference Journal.2020; 9(4): 170.     CrossRef
  • Comparison of extended right hemicolectomy, left hemicolectomy and segmental colectomy for splenic flexure colon cancer: a systematic review and meta‐analysis
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    Colorectal Disease.2020; 22(12): 1885.     CrossRef
  • Segmental Colonic Resection Is a Safe and Effective Treatment Option for Colon Cancer of the Splenic Flexure: A Nationwide Retrospective Study of the Italian Society of Surgical Oncology–Colorectal Cancer Network Collaborative Group
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    Diseases of the Colon & Rectum.2020; 63(10): 1372.     CrossRef
  • Clinical–Pathologic Characteristics and Long-term Outcomes of Left Flexure Colonic Cancer: A Retrospective Analysis of an International Multicenter Cohort
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    Diseases of the Colon & Rectum.2020; 63(12): 1593.     CrossRef
  • Short- and long-term outcomes after transverse versus extended colectomy for transverse colon cancer. A systematic review and meta-analysis
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    International Journal of Colorectal Disease.2019; 34(2): 201.     CrossRef
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    Colorectal Disease.2019; 21(9): 1090.     CrossRef
  • Treatment of splenic flexure colon cancer: a comparison of three different surgical procedures: Experience of a high volume cancer center
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  • Intracorporeal Versus Extracorporeal Anastomosis for Laparoscopic Resection of the Splenic Flexure Colon Cancer: A Multicenter Propensity Score Analysis
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  • Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia
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  • Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure
    Jin Cheon Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Seok‐Byeong Lim
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  • Propensity score analysis of postoperative and oncological outcomes after surgical treatment for splenic flexure colon cancer
    J. Martín Arévalo, D. Moro-Valdezate, S. A. García-Botello, V. Pla-Martí, M. Garcés-Albir, L. Pérez Santiago, A. Vargas-Durán, A. Espí-Macías
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  • How we do it: totally laparoscopic complete mesocolon excision for splenic flexure cancer
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  • Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery
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  • Surgical Treatment of Colon Cancer of the Splenic Flexure: A Systematic Review and Meta-analysis
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  • Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case–control study
    Nicola de’Angelis, Elisabeth Hain, Mara Disabato, Cristiana Cordun, Maria Clotilde Carra, Daniel Azoulay, Francesco Brunetti
    International Journal of Colorectal Disease.2016; 31(3): 623.     CrossRef
  • Laparoscopic resection of splenic flexure tumors
    Massimo Carlini, Domenico Spoletini, Fabio Castaldi, Cristiano Giovannini, Umberto Passaro
    Updates in Surgery.2016; 68(1): 77.     CrossRef
  • Operative Method for Transverse Colon Carcinoma: Transverse Colectomy Versus Extended Colectomy
    Choon Seng Chong, Jung Wook Huh, Bo Young Oh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee
    Diseases of the Colon & Rectum.2016; 59(7): 630.     CrossRef
  • Optimum Level of Vessel Ligation in Splenic Flexure Cancer
    Kim Nam Kyu
    Journal of Surgery and Surgical Research.2016; : 055.     CrossRef
  • Splenic flexure colon cancers: minimally invasive treatment
    Valentino Fiscon, Giuseppe Portale, Giovanni Migliorini, Flavio Frigo
    Updates in Surgery.2015; 67(1): 55.     CrossRef
  • Laparoscopic colonic resection for splenic flexure cancer: our experience
    Andrea Pisani Ceretti, Nirvana Maroni, Matteo Sacchi, Stefano Bona, Maria Rachele Angiolini, Paolo Bianchi, Enrico Opocher, Marco Montorsi
    BMC Gastroenterology.2015;[Epub]     CrossRef
  • The short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis
    Manfred Odermatt, Najaf Siddiqi, Rose Johns, Danilo Miskovic, Omar Khan, Jim Khan, Amjad Parvaiz
    Surgery Today.2014; 44(11): 2045.     CrossRef
  • Elective subtotal colectomy with ileosigmoid anastomosis for colon cancer preserves bowel function and quality of life
    G. Manceau, E. d'Annunzio, M. Karoui, S. Breton, G. Rousseau, A. S. Blanchet, J. C. Vaillant, L. Hannoun
    Colorectal Disease.2013; 15(9): 1078.     CrossRef
  • Totally laparoscopic resection of the splenic flexure for tumor
    Francesco Roscio, Camillo Bertoglio, Antonio De Luca, Paolo Frattini, Federico Clerici, Ildo Scandroglio
    Updates in Surgery.2012; 64(3): 185.     CrossRef
  • Does the outcome of colonic flexure cancers differ from the other colonic sites?
    Irshad A. Shaikh, Stuart A. Suttie, Mary Urquhart, Amin I. Amin, Thomas Daniel, Satheesh Yalamarthi
    International Journal of Colorectal Disease.2012; 27(1): 89.     CrossRef
  • Colon Cancer in the Splenic Flexure
    Masayuki Nakashima, Takashi Akiyoshi, Masashi Ueno, Yosuke Fukunaga, Satoshi Nagayama, Yoshiya Fujimoto, Tsuyoshi Konishi, Rota Noaki, Keiko Yamakawa, Yasutomo Nagasue, Hiroya Kuroyanagi, Toshiharu Yamaguchi
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2011; 21(6): 415.     CrossRef
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