Cancer Research and Treatment

Case Report

The Role of Radiation Therapy for the Extramammary Paget's Disease of the Vulva ; Experience of 3 Cases: Seok-Hyun Son, Jung-Seok Lee, Yeon-Sil Kim, Mi-Ryeong Ryu, Su-Mi Chung, Sung-Eun Namkoong, Gu-Taek Han, Hee-Jeong Lee, Sei-Chul Yoon; Cancer Res Treat. 2005;37(6):365-369. Published online December 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.6.365

We have experienced three cases of extramammary Paget's disease (EMPD) of the vulva that received radiation therapy (RT). Here, we analyze the efficacy of RT and include a literature survey.

Three patients with EMPD of the vulva were treated with curative RT between 1993 and 1998. One of the patients had associated underlying adenocarcinoma of the vulva. The total doses of radiation administered were 54~78 Gy/6~8 weeks. Radiation fields encompassed 2 to 3 cm outer margins free from all visible disease including or not including the inguinal area using a 9 MeV electron or a 6 MV photon beam. Follow-up durations after radiotherapy were 0.6~11 years. Complete response was obtained in all three patients. Marginal failure occurred in one patient, and another patient with underlying adenocarcinoma treated by vulvectomy with bilateral inguinal lymph node dissection followed by external RT showed no relapse. Radiation induced side effects were transient acute confluent wet desquamation in the treated area resulting in mild late atrophic skin changes.

Although surgery is currently considered the preferred primary treatment for EMPD, it has a high relapse rate due to the multifocal nature of the disease. We conclude that RT is of benefit in some selected cases of EMPD.

Citations

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Anatomic Subtype Differences in Extramammary Paget Disease
Nour Kibbi, Joshua L. Owen, Brandon Worley, Jake X. Wang, Vishnu Harikumar, Sumaira Z. Aasi, Sunandana Chandra, Jennifer N. Choi, Yasuhiro Fujisawa, Christos Iavazzo, John Y. S. Kim, Naomi Lawrence, Mario M. Leitao, Allan B. MacLean, Jeffrey S. Ross, Anth
JAMA Dermatology.2024; 160(4): 417. CrossRef
Vulvar Paget Disease: a series of cases in southern Brazil
Marcella B. Persiano, Elisa T. Rosin, Giovana A. Cabrera, Fernanda Uratani, Leticia V. Pires, Felipe Luzzatto, Kathleen M. Schmeler, Mila P. Salcedo
Journal of Global Health Reports.2023;[Epub] CrossRef
The Paget Trial: topical 5% imiquimod cream for noninvasive vulvar Paget disease
Michelle van der Linden, Colette L. van Hees, Marc van Beurden, Johan Bulten, Eleonora B. van Dorst, Martha D. Esajas, Kim A. Meeuwis, Dorry Boll, Mariëtte I. van Poelgeest, Joanne A. de Hullu
American Journal of Obstetrics and Gynecology.2022; 227(2): 250.e1. CrossRef
Genomic Alterations as Potential Therapeutic Targets in Extramammary Paget’s Disease of the Vulva
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JCO Precision Oncology.2020; (4): 1054. CrossRef
Invasive Vulval Paget’s disease treated with primary radiotherapy: A rare case report and literature review
Avir Sarkar, S.C. Saha, Pooja Sikka, Neha Kumari, Pranab Dey, Bhavana Rai
Gynecologic Oncology Reports.2020; 34: 100674. CrossRef
Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis
Igor Snast, Eran Sharon, Ran Kaftory, Yehonatan Noyman, Meital Oren-Shabtai, Moshe Lapidoth, Emmilia Hodak, Daniel Mimouni, Sigal Mazor, Assi Levi
Dermatology.2020; 236(6): 493. CrossRef
A Rare Case of Recurrent Paget’s Disease of the Vulva and Gluteal Region Treated with Radiation Therapy
Mirza Athar Ali, M. Babaiah, Prabhakar Mariappan, Sudha Sinha, KR Muralidhar, Srinivas Ponaganti, Pranav Ashwin Shah, Sujana Priya Vuba, Arun Kumar Reddy Gorla, Deepak Koppaka
Applied Radiation Oncology.2020; : 44. CrossRef
Efficacy of low‐dose 5‐fluorouracil/cisplatin therapy for invasive extramammary Paget's disease
Hiroshi Kato, Shoichi Watanabe, Kiyonori Kariya, Motoki NAKAMURA, Akimichi Morita
The Journal of Dermatology.2018; 45(5): 560. CrossRef
The Role of Radiotherapy in Extramammary Paget Disease
L. Tagliaferri, C. Castà, G. Macchia, A. Pesce, G. Garganese, B. Gui, G. Perotti, S. Gentileschi, F. Inzani, R. Autorino, S. Cammelli, A.G. Morganti, V. Valentini, M.A. Gambacorta
International Journal of Gynecological Cancer.2018; 28(4): 829. CrossRef
The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
JMIR Research Protocols.2017; 6(9): e178. CrossRef
Paget disease of the vulva
M. van der Linden, K.A.P. Meeuwis, J. Bulten, T. Bosse, M.I.E. van Poelgeest, J.A. de Hullu
Critical Reviews in Oncology/Hematology.2016; 101: 60. CrossRef
Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?
Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias, George Kyrgias
BMC Cancer.2016;[Epub] CrossRef
Extramammary Paget Disease of the Vulva: Minimal Excision with Adjuvant Radiation Treatment for Optimal Aesthetic Results
Myeong Su Jeon, Gyu Yong Jung, Joon Ho Lee, Kyung Won Kang, Kwang Won No
Tumori Journal.2016; 102(2_suppl): S84. CrossRef
Paget Disease of the Vulva: Diagnosis by Immunohistochemistry
Andressa Gonçalves Amorim, Brunelle Batista Fraga Mendes, Rodrigo Neves Ferreira, Antônio Chambô Filho
Case Reports in Dermatological Medicine.2015; 2015: 1. CrossRef
Radiation therapy for extramammary Paget's disease: treatment outcomes and prognostic factors
M. Hata, I. Koike, H. Wada, E. Miyagi, T. Kasuya, H. Kaizu, T. Matsui, Y. Mukai, E. Ito, T. Inoue
Annals of Oncology.2014; 25(1): 291. CrossRef
Radiotherapy in Patients with Extramammary Paget's Disease - Our Own Experience and Review of the Literature
Tomohiro Itonaga, Hidetsugu Nakayama, Mitsuru Okubo, Ryuji Mikami, Sachica Nogi, Yu Tajima, Shinji Sugahara, Koichi Tokuuye
Oncology Research and Treatment.2014; 37(1-2): 18. CrossRef
Extramammary Paget's Disease of the Vulva: A Case Report and Review of the Literature
Nirmala Duhan, Mansi Juneja, Sunita Singh
Journal of Gynecologic Surgery.2013; 29(6): 297. CrossRef
HDR-plesiotherapy for the treatment of anogenital extramammary Paget's disease
Soraya Marcos, Angel Montero, Belén Capuz, Javier Martinez-Ollero, Raúl Hernanz, Eva Fernández, Alfredo Polo, Alfredo Ramos
Reports of Practical Oncology & Radiotherapy.2012; 17(3): 163. CrossRef
Extramammary Paget's disease treated with topical imiquimod 5% cream
Sue-Ann J. E. Ho, Derrick C. W. Aw
Dermatologic Therapy.2010; 23(4): 423. CrossRef

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Original Articles

Immunization with Adenoviral Vectors Carrying Recombinant IL-12 and E7 Enhanced the Antitumor Immunity against Human Papillomavirus 16-associated Tumor: Eun-Kyung Park, Young-Wook Kim, Joon-Mo Lee, Sung-Eun NamKoong, Do-Gang Kim, Heung-Jae Chun, Byoung-Don Han, Su-Mi Bae, Hyun-Sun Jin, Jeong-Im Sin, Woong-Shick Ahn; Cancer Res Treat. 2005;37(1):63-70. Published online February 28, 2005; DOI: https://doi.org/10.4143/crt.2005.37.1.63

Abstract PDF PubReader ePub

Purpose

Human papillomavirus (HPV) infection has a significant role in cervical carcinogenesis, and HPV oncoprotein E7 plays an important part in the formation and maintenance of cervical cancer. Interleukin-12 (IL-12) has been reported to induce a cellular immune response, and to suppress the tumor growth and the E7 production. Here we describe the use of adenoviral delivery of the HPV 16 E7 subunit (AdE7) along with adenoviral delivery of IL-12 (AdIL-12) in mice with HPV-associated tumors.

Materials and Methods

Mice were injected with TC-1 cells to establish TC-1 tumor, and then they were immunized with AdIL-12 and/or AdE7 intratumorally. The anti tumor effects induced by AdIL-12 and/or E7 were evaluated by measuring the size of the tumor. E7-specific antibody and INF-γ production in sera, and the T-helper cell proliferative responses were then measured. Cytotoxic T-lymphocyte (CTL) and T cell subset depletion studies were also performed.

Results

Combined AdIL-12 and AdE7 infection at the tumor sites significantly enhanced the antitumor effects more than that of AdIL-12 or AdE7 single infection. This combined infection resulted in regression of the 9 mm sized tumors in 80% of animals as compare to the PBS group. E7-specific antibody and INF-γ production in the sera, and the T-helper cell proliferative responses were significantly higher with coinfection of AdIL-12 and AdE7 than with AdIL-12 or AdE7 alone. CTL response induced by AdIL-12 and AdE7 in the coinjected group suggested that tumor suppression was mediated by mostly CD8+ and only a little by the CD4+ T cells.

Conclusion

IL-12 and E7 application using adenovirus vector showed antitumor immunity effects against TC-1 tumor, and this system could be use in clinical applications for HPV-associated cancer. (ED note: nice abstract.)

Citations

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Development of a replication‐deficient adenoviral vector‐based vaccine candidate for the interception of HPV16‐ and HPV18‐induced infections and disease
Selina Khan, Koen Oosterhuis, Kerstin Wunderlich, Evelien M. Bunnik, Melissa Bhaggoe, Satish Boedhoe, Santusha Karia, Renske D.M. Steenbergen, Leontien Bosch, Jan Serroyen, Sarah Janssen, Hanneke Schuitemaker, Jort Vellinga, Gert Scheper, Roland Zahn, Jer
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Jiarong Xu, Dongyan Huang, shichao Liu, Huixing Lin, Haodan Zhu, Bao Liu, Chengping Lu
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Virus Research.2012; 167(2): 188. CrossRef

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Proteome Analysis of Differential Protein Expression in Cervical Cancer Cells after Paclitaxel Treatment: Eun-Kyoung Yim, Jun-Sang Bae, Seung-Bak Lee, Keun-Ho Lee, Chan-Joo Kim, Sung-Eun Namkoong, Soo-Jong Um, Jong-Sup Park; Cancer Res Treat. 2004;36(6):395-399. Published online December 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.6.395

Abstract PDF PubReader ePub

Purpose

It is well known that infection with HPV (human papillomavirus) is the main cause of cervical cancer and certain types of HPV are recognized as carcinogens. At present, there is little information regarding the antineoplastic mechanism of paclitaxel against cervical carcinoma cells. We thus tried to analyze differential protein expression and antineoplastic mechanism-related proteins after paclitaxel treatment on cervical cancer cells by using a proteomic analysis and to investigate the mechanism of action.

Materials and Methods

Using proteomics analysis including 2-DE and MALDI-TOF-MS, we detected the antineoplastic mechanism-related proteins. Then, we performed western blot analysis for apoptosis- and transformation-related proteins to confirm expression patterns derived from proteome analysis after paclitaxel treatment.

Results

We identified several cellular proteins that are responsive to paclitaxel treatment in HeLa cells using proteomics methods. Paclitaxel treatment elevated mainly apoptosis, immune response and cell cycle check point-related proteins. On the other hand, paclitaxel treatment diminished growth factor/oncogene-related proteins and transcription regulation-related proteins. Also, in the HPV-associated cervical carcinoma cells, paclitaxel demonstrated anti-proliferative activity through the membrane death receptor-mediated apoptotic pathway and the mitochondrial-mediated pathway.

Conclusion

Identification and characterization of functionally modulated proteins involved in anti-cancer regulatory events should lead to a better understanding of the long-term actions of paclitaxel at the molecular level and will contribute to the future development of novel therapeutic drug treatments based upon current therapies.

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Georgia Kontostathi, Jerome Zoidakis, Nicholas P. Anagnou, Kalliopi I. Pappa, Antonia Vlahou, Manousos Makridakis
Expert Review of Proteomics.2016; 13(8): 731. CrossRef
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Journal of Proteomics.2011; 74(12): 2760. CrossRef

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Photodynamic Effects of Radachlorin® on Cervical Cancer Cells: Su-Mi Bae, Yong-Wook Kim, Joon-Mo Lee, Sung-Eun Namkoong, Sei-Jun Han, Jong-Ki Kim, Chang-Hee Lee, Heung-Jae Chun, Hyun-Sun Jin, Woong-Shick Ahn; Cancer Res Treat. 2004;36(6):389-394. Published online December 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.6.389

Abstract PDF PubReader ePub

Purpose

Photodynamic therapy (PDT) is a novel treatment modality, which produces local tissue necrosis with laser light following the prior administration of a photosensitizing agent. Radachlorin® has recently been shown to be a promising PDT sensitizer. In order to elucidate the antitumor effects of PDT using Radachlorin® on cervical cancer, growth inhibition studies on a HPV-associated tumor cell line, TC-1 cells in vitro and animals with an established TC-1 tumor in vivo were determined.

Materials and Methods

TC-1 tumor cells were exposed to various concentrations of Radachlorin® and PDT, with irradiation of 12.5 or 25 J/cm² at an irradiance of 20 mW/cm² using a Won-PDT D662 laser at 662 nm in vitro. C57BL/6 mice with TC-1 tumor were injected with Radachlorin® via different routes and treated with PDT in vivo. A growth suppression study was then used to evaluate the effects at various time points after PDT.

Results

The results showed that irradiation of TC-1 tumor cells in the presence of Radachlorin® induced significant cell growth inhibition. Animals with established TC-1 tumors exhibited significantly smaller tumor sizes over time when treated with Radachlorin® and irradiation.

Conclusion

PDT after the application of Radachlorin® appears to be effective against TC-1 tumors both in vitro and in vivo.

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Clinical Cancer Research.2016; 22(6): 1459. CrossRef
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