Cancer Research and Treatment

Pediatric Adenocarcinoma in Korea: A Multicenter Study: Hee-Beom Yang, Jung-Man Namgoong, Ki Hoon Kim, Dae Yeon Kim, Jinyoung Park, Hyun Beak Shin, Joong Kee Youn, Sanghoon Lee, Ji Won Lee, Sung Eun Jung, Jae Hee Chung, Yun-Mee Choe, Tae Gil Heo, In Geol Ho, Hyun-Young Kim; Cancer Res Treat. 2020;52(1):117-127. Published online June 3, 2019; DOI: https://doi.org/10.4143/crt.2019.092

Abstract PDF Supplementary Material PubReader ePub

Purpose
Adenocarcinoma is an extremely rare malignancy in the pediatric population. Research regarding pediatric adenocarcinoma is very rare in Korea. This study aimed to investigate the clinical features of pediatric adenocarcinomas of various primary organ sites in Korea.
Materials and Methods
Pediatric patients under 18 years, diagnosed with adenocarcinoma of various sites between January 1995 and December 2016, were included. We retrospectively reviewed patient and tumor characteristics and calculated survival estimates, reported as 5-year survival rate and 95% confidence interval.
Results
Of 80 patients (median age, 15 years; range, 10 to 17 years), 37 (46.3%) were men, and 24 (30%) had a family history of cancer or underlying disease relevant to malignancy. The cancer locations were the colon and rectum (n=32), ovaries (n=18), stomach (n=15), lung (n=4), small bowel (n=1), and other sites (n=10). Totally, 54.8% patients (42/77) had stage 3 or 4 disease. The median follow-up period was 2.0 years (range, 0 to 20.4). The 5-year overall survival estimate for all patients, and for those with stomach, colorectal, ovarian, and other cancer sites were 57.9%±11.5%, 58.2%±25.7%, 41.5%±18.2%, 87.5%±16.2%, and 64.0%±34.4%, respectively. The 5-year survival rate differed significantly between categories of adenocarcinomas into gastrointestinal (GI) (44.7%) and non-GI adenocarcinomas (78.8%) (p=0.007). The 5-year survival rate also differed significantly according to carcinoembryonic antigen level (69.3% in < 3 ng/mL, 23.8% in > 3 ng/mL; p < 0.001).
Conclusion
In pediatric patients, adenocarcinomas arise from various organs and are often diagnosed at advanced stages. Large, prospective studies for their accurate clinical characteristics and prognostic factors are needed.

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Pediatric Pancreatic Tumors: Dae Yeon Kim, Min Gew Choi, Ki Hong Kim, In One Kim, Sung Eun Jung, Seong Cheol Lee, Kwi Won Park, Woo Ki Kim; J Korean Cancer Assoc. 1999;31(4):830-835.

Abstract PDF: PURPOSE
Pancreatic tumors are relatively rare in children. Until now more than 150 cases have been reported in the English literature. In this paper, the authors report the tumors clinical characteristics and the results of surgery in eleven children.
MATERIALS AND METHODS
Eleven cases of pancreatic tumor pathologically verified at Seoul National University Children's Hospital between 1984 to 1998 were retrospectively analyzed. Four were boys and seven were girls, and their mean age at diagnosis was 7.7 (range, 2 13) years.
RESULTS
There were six solid and papillary epithelial neoplasms of the pancreas (SPENP) and five pancreatoblastomas. All children came to medical attention because of abdominal masses. Tumors ranged in size from 6.0X 5.0 cm to 10.5 x 8.0 cm. Eight tumors were located in head and three in tail. Complete excision was performed in eight cases (six in SPENP and two in pancreatoblastoma). Incomplete excision was performed in two cases of pancreatoblastoma. One patient with pancreatoblastoma had an unresectable tumor at the time of diagnosis and needle aspiration biopsy was done under the ultrasound guidance. No patient died during surgery. After a mean follow-up period of 4.1 years, all patients with SPENP were alive and there had been no recurrence. However, of two patients who received complete excision in pancreatoblastoma, one presented with liver metastasis at 4 months after operation and received chemotherapy, but died 6 months after operation. The other patient had local recurrence 1 year after operation. Reoperation and chemotherapy were performed and the child is now alive without evidence of disease montbs after the initial operation. All three patients with unresectable tumor died in spite of adjuvant radiotherapy and chemotherapy.
CONCLUSION
Pediatric pancreatic tumors comprise rare heterogenous groups of malignancies with their prognosis dependent upon adequate resection and pathologic classification. Complete resection of pancreatic tumors arising anywhere in the pancreas was recommended.

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The Significance of the Measurement of Immunosuppressive Acid Protein ( IAP ): Jin Pok Kim, Sung Eun Jung, Yoon Baek Choi, Jung Taik Kim; J Korean Cancer Assoc. 1985;17(2):271-276.

Abstract PDF: To evaluate the significance and the relationship between serum IAP level and the posto- perative pragression of the cancer, we measured IAP level in 42 stomach cancer patients, 11 colorectal cancer patients, and 12 breast cancer patients 2 years after curative surgery was performed as well as the preoperative IAP level of 54 stomach cancer patients, 28 colorectal cancer patients, and 24 breast cancer patients. 1) IAP level in preaperative stomach cancer patients was 596. 2+210. 5 g/ml, 51.8%. positive rate, and in postoperative patients, 352.8+67. 3 g/ml, 0 positive rate. 2) In preoperative colorectal cancer patients, IAP level was 519.8 +- 195.2 g/ml, 50.0% positive rate, and in postoperative patients 401.2+-140.3 g/ml, 9.1% positive rate. 3) In preoperative breast cancer patients, IAP level was 499. 6+ 170. 3 g/ml, 45. SM positive rate and in postoperative patients, 365.0+- 20.6 g/ml, 0% positive rate. 4) The change of IAP level as well as DNCB and T-cell count showed positive correlation with progression and surgical treatment in stomach cancer. We concluded that the measurement of serum IAP level in cancer patients is an useful tool as an immune parameter study for the postoperative progression of the cancer.

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Staging Patients with Gastric Cancer and Their Prognosis: Jin Pok Kim, Sung Eun Jung; J Korean Cancer Assoc. 1986;18(1):9-14.

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