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- Genetic Alterations in Preinvasive Lung Synchronous Lesions
- Soyeon Ahn, Jisun Lim, Soo Young Park, Hyojin Kim, Hyun Jung Kwon, Yeon Bi Han, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung
- Cancer Res Treat. 2020;52(4):1120-1134. Published online June 5, 2020
- DOI: https://doi.org/10.4143/crt.2020.307
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Abstract
PDF
Supplementary Material
PubReader
ePub - Purpose
Despite advances in treatment, lung cancer remains the leading cause of cancer mortality. This study aimed to characterise genome-wide tumorigenesis events and to understand the hypothesis of the multistep carcinogenesis of lung adenocarcinoma (LUAD)
Materials and Methods
We conducted multiregion whole-exome sequencing of LUAD with synchronous atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ, or minimally invasive adenocarcinoma of 19 samples from three patients to characterize genome-wide tumorigenesis events and validate the hypothesis of the multistep carcinogenesis of LUAD. We identified potential pathogenic mutations preserved in preinvasive lesions and supplemented the finding by allelic variant level from RNA sequencing.
Results
Overall, independent mutational profiles were observed per patient and between patients. Some shared mutations including epidermal growth factor receptor (EGFR , p.L858R) were present across synchronous lesions.
Conclusion
Here, we show that there are driver gene mutations in AAH, and they may exacerbate as a sequence in a histological continuum, supporting the Darwinian evolution model of cancer genome. The intertumoral and intratumoral heterogeneity of synchronous LUAD implies that multi-biomarker strategies might be necessary for appropriate treatment. -
Citations
Citations to this article as recorded by
- Gene Expression Profiles of Multiple Synchronous Lesions in Lung Adenocarcinoma
Jisun Lim, Yeon Bi Han, Soo Young Park, Soyeon Ahn, Hyojin Kim, Hyun Jung Kwon, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung
Cells.2021; 10(12): 3484. CrossRef
- Gene Expression Profiles of Multiple Synchronous Lesions in Lung Adenocarcinoma
- 8,386 View
- 153 Download
- 2 Web of Science
- 1 Crossref
- Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
- Hyung-Jun Kim, Jun Yeun Cho, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Sukki Cho, Kwhanmien Kim, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
- Cancer Res Treat. 2019;51(4):1540-1548. Published online March 25, 2019
- DOI: https://doi.org/10.4143/crt.2019.057
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival.
Materials and Methods
Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed.
Results
Among 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91).
Conclusion
Concurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients. -
Citations
Citations to this article as recorded by- A CT-based deep learning model: visceral pleural invasion and survival prediction in clinical stage IA lung adenocarcinoma
Xiaofeng Lin, Kunfeng Liu, Kunwei Li, Xiaojuan Chen, Biyun Chen, Sheng Li, Huai Chen, Li Li
iScience.2024; 27(1): 108712. CrossRef - CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer
Yun Wang, Deng Lyu, Lei Hu, Junhong Wu, Shaofeng Duan, Taohu Zhou, Wenting Tu, Yi Xiao, Li Fan, Shiyuan Liu
Journal of Imaging Informatics in Medicine.2024; 37(2): 520. CrossRef - Prognostic Analysis of Stage I Non-Small Cell Lung Cancer Abutting Adjacent Structures on Preoperative Computed Tomography
Soohwan Choi, Sun Kyun Ro, Seok Whan Moon
Journal of Chest Surgery.2024; 57(2): 136. CrossRef - Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma
Yun Wang, Deng Lyu, Su Hu, Yanqing Ma, Shaofeng Duan, Yayuan Geng, Taohu Zhou, Wenting Tu, Yi Xiao, Li Fan, Shiyuan Liu
Journal of Cardiothoracic Surgery.2024;[Epub] CrossRef - Nomogram for predicting invasive lung adenocarcinoma in small solitary pulmonary nodules
Mengchao Xue, Rongyang Li, Junjie Liu, Ming Lu, Zhenyi Li, Huiying Zhang, Hui Tian
Frontiers in Oncology.2024;[Epub] CrossRef - Analysis of postoperative recurrence-free survival in non–small cell lung cancer patients based on consensus clustering
Q. Tian, S.-Y. Zhou, Y.-H. Qin, Y.-Y. Wu, C. Qin, H. Zhou, J. Shi, S.-F. Duan, F. Feng
Clinical Radiology.2024; 79(10): e1214. CrossRef - Predicting bone metastasis-free survival in non-small cell lung cancer from preoperative CT via deep learning
Jia Guo, Jianguo Miao, Weikai Sun, Yanlei Li, Pei Nie, Wenjian Xu
npj Precision Oncology.2024;[Epub] CrossRef - Tumour–pleura relationship on CT is a risk factor for occult lymph node metastasis in peripheral clinical stage IA solid adenocarcinoma
Chengzhou Zhang, Liping Wang, Xiaoting Cai, Mengfei Li, Dandan Sun, Ping Wang
European Radiology.2023; 33(5): 3083. CrossRef - Analysis of the relevance between computed tomography characterization and pathology of pulmonary ground-glass nodules with different pathology types
Zhang Youguo, Wang Chengye, Cheng Xiaofei, Zhang Xuefei, Liu Changhong
Turkish Journal of Thoracic and Cardiovascular Surgery.2023; 31(1): 95. CrossRef - Risk factors for loss of pulmonary function after wedge resection for peripheral ground-glass opacity dominant lung cancer
Tomohiro Miyoshi, Hiroyuki Ito, Masashi Wakabayashi, Tadayoshi Hashimoto, Yuta Sekino, Kenji Suzuki, Masahiro Tsuboi, Yasumitsu Moriya, Ichiro Yoshino, Tetsuya Isaka, Aritoshi Hattori, Takahiro Mimae, Mitsuhiro Isaka, Tomohiro Maniwa, Makoto Endo, Hiroshi
European Journal of Cardio-Thoracic Surgery.2023;[Epub] CrossRef - Volumetric analysis of intravoxel incoherent motion diffusion-weighted imaging in preoperative assessment of non-small cell lung cancer
Jianqin Jiang, Yigang Fu, Lili Zhang, Jia Liu, Xiaowen Gu, Weiwei Shao, Lei Cui, Gaofeng Xu
Japanese Journal of Radiology.2022; 40(9): 903. CrossRef - A Nomogram Combined Radiomics and Clinical Features as Imaging Biomarkers for Prediction of Visceral Pleural Invasion in Lung Adenocarcinoma
Xinyi Zha, Yuanqing Liu, Xiaoxia Ping, Jiayi Bao, Qian Wu, Su Hu, Chunhong Hu
Frontiers in Oncology.2022;[Epub] CrossRef - Radiologists with and without deep learning–based computer-aided diagnosis: comparison of performance and interobserver agreement for characterizing and diagnosing pulmonary nodules/masses
Tomohiro Wataya, Masahiro Yanagawa, Mitsuko Tsubamoto, Tomoharu Sato, Daiki Nishigaki, Kosuke Kita, Kazuki Yamagata, Yuki Suzuki, Akinori Hata, Shoji Kido, Noriyuki Tomiyama
European Radiology.2022; 33(1): 348. CrossRef - The value of CT radiomics features to predict visceral pleural invasion in ≤3 cm peripheral type early non-small cell lung cancer
Shu-Hua Wei, Jin-Mei Zhang, Bin Shi, Fei Gao, Zhao-Xuan Zhang, Li-Ting Qian
Journal of X-Ray Science and Technology.2022; 30(6): 1115. CrossRef - Pathological components and CT imaging analysis of the area adjacent pleura within the pure ground-glass nodules with pleural deformation in invasive lung adenocarcinoma
Yining Jiang, Ziqi Xiong, Wenjing Zhao, Di Tian, Qiuping Zhang, Zhiyong Li
BMC Cancer.2022;[Epub] CrossRef - Development and validation of a deep learning signature for predicting lymph node metastasis in lung adenocarcinoma: comparison with radiomics signature and clinical-semantic model
Xiaoling Ma, Liming Xia, Jun Chen, Weijia Wan, Wen Zhou
European Radiology.2022; 33(3): 1949. CrossRef - Lung-RADS Version 1.1: Challenges and a Look Ahead, From the AJR Special Series on Radiology Reporting and Data Systems
Lydia Chelala, Rydhwana Hossain, Ella A. Kazerooni, Jared D. Christensen, Debra S. Dyer, Charles S. White
American Journal of Roentgenology.2021; 216(6): 1411. CrossRef - Predicting pathological lymph node status in clinical stage IA peripheral lung adenocarcinoma
Keiju Aokage, Kenji Suzuki, Masashi Wakabayashi, Tomonori Mizutani, Aritoshi Hattori, Haruhiko Fukuda, Shun-Ichi Watanabe
European Journal of Cardio-Thoracic Surgery.2021; 60(1): 64. CrossRef - Discriminating Small-Sized (2 cm or Less), Noncalcified, Solitary Pulmonary Tuberculoma and Solid Lung Adenocarcinoma in Tuberculosis-Endemic Areas
Jingping Zhang, Tingting Han, Jialiang Ren, Chenwang Jin, Ming Zhang, Youmin Guo
Diagnostics.2021; 11(6): 930. CrossRef - Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma
Yanyan Zhang, Fengnian Zhao, Minghao Wu, Yunqing Zhao, Ying Liu, Qian Li, Guiming Zhou, Zhaoxiang Ye
European Journal of Radiology.2021; 141: 109802. CrossRef - Characterization of Newly Detected Costal Pleura–attached Noncalcified Nodules at Annual Low-Dose CT Screenings
Yeqing Zhu, Rowena Yip, Nan You, Qiang Cai, Claudia I. Henschke, David F. Yankelevitz, Claudia I. Henschke, David F. Yankelevitz, Rowena Yip, Dongming Xu, Mary Salvatore, Raja Flores, Andrea Wolf, David S. Mendelson, Dorothy I. McCauley, Mildred Chen, Dan
Radiology.2021; 301(3): 724. CrossRef - Clinicopathological and computed tomographic features associated with occult lymph node metastasis in patients with peripheral solid non-small cell lung cancer
Xiao-Qun He, Tian-You Luo, Xian Li, Ji-Wen Huo, Jun-Wei Gong, Qi Li
European Journal of Radiology.2021; 144: 109981. CrossRef - Surgical Extent for Ground Glass Nodules
Suk Ki Cho
Journal of Chest Surgery.2021; 54(5): 338. CrossRef - CT-guided microcoil localization for pulmonary nodules before VATS: a retrospective evaluation of risk factors for pleural marking failure
Yanyan Xu, Lingchuan Ma, Hongliang Sun, Zhenguo Huang, Zhenrong Zhang, Fei Xiao, Qianli Ma, Chuandong Li, Xiaomeng Zhang, Sheng Xie
European Radiology.2020; 30(10): 5674. CrossRef - Management of Nodules Attached to the Costal Pleura at Low-Dose CT Screening for Lung Cancer
Yeqing Zhu, Rowena Yip, Nan You, Claudia I. Henschke, David F. Yankelevitz
Radiology.2020; 297(3): 710. CrossRef
- A CT-based deep learning model: visceral pleural invasion and survival prediction in clinical stage IA lung adenocarcinoma
- 9,495 View
- 212 Download
- 31 Web of Science
- 25 Crossref
- Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients
- Se-Hoon Lee, Boram Lee, Joon Ho Shim, Kwang Woo Lee, Jae Won Yun, Sook-Young Kim, Tae-You Kim, Yeul Hong Kim, Young Hyeh Ko, Hyun Cheol Chung, Chang Sik Yu, Jeeyun Lee, Sun Young Rha, Tae Won Kim, Kyung Hae Jung, Seock-Ah Im, Hyeong-Gon Moon, Sukki Cho, Jin Hyoung Kang, Jihun Kim, Sang Kyum Kim, Han Suk Ryu, Sang Yun Ha, Jong Il Kim, Yeun-Jun Chung, Cheolmin Kim, Hyung-Lae Kim, Woong-Yang Park, Dong-Young Noh, Keunchil Park
- Cancer Res Treat. 2019;51(1):211-222. Published online April 23, 2018
- DOI: https://doi.org/10.4143/crt.2018.132
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian populations, the prevalence and spectrum of clinically actionable genetic alterations has not yet been determined because of a lack of studies examining high-throughput cancer genomic data.
Materials and Methods
To address this issue, 1,071 tumor samples were collected from five major cancer institutes in Korea and analyzed using targeted NGS at a centralized laboratory. Samples were either fresh frozen or formalin-fixed, paraffin embedded (FFPE) and the quality and yield of extracted genomic DNA was assessed. In order to estimate the effect of sample condition on the quality of sequencing results, tissue preparation method, specimen type (resected or biopsied) and tissue storage time were compared.
Results
We detected 7,360 non-synonymous point mutations, 1,164 small insertions and deletions, 3,173 copy number alterations, and 462 structural variants. Fifty-four percent of tumors had one or more clinically relevant genetic mutation. The distribution of actionable variants was variable among different genes. Fresh frozen tissues, surgically resected specimens, and recently obtained specimens generated superior sequencing results over FFPE tissues, biopsied specimens, and tissues with long storage duration.
Conclusion
In order to overcome, challenges involved in bringing NGS testing into routine clinical use, a centralized laboratory model was designed that could improve the NGS workflows, provide appropriate turnaround times and control costs with goal of enabling precision medicine. -
Citations
Citations to this article as recorded by- Real-World Data and Clinical Implications of Next-Generation Sequencing (NGS)-Based Analysis in Metastatic Breast Cancer Patients
Fabio Canino, Antonio Tornincasa, Stefania Bettelli, Samantha Manfredini, Monica Barbolini, Luca Moscetti, Claudia Omarini, Angela Toss, Fabio Tamburrano, Giuseppina Antonelli, Federica Baglio, Lorenzo Belluzzi, Giulio Martinelli, Salvatore Natalizio, Orn
International Journal of Molecular Sciences.2024; 25(5): 2490. CrossRef - Exploring the DNA methylome of Korean patients with colorectal cancer consolidates the clinical implications of cancer-associated methylation markers
Sejoon Lee, Kil-yong Lee, Ji-Hwan Park, Duck-Woo Kim, Heung-Kwon Oh, Seong-Taek Oh, Jongbum Jeon, Dongyoon Lee, Soobok Joe, Hoang Bao Khanh Chu, Jisun Kang, Jin-Young Lee, Sheehyun Cho, Hyeran Shim, Si-Cho Kim, Hong Seok Lee, Young-Joon Kim, Jin Ok Yang,
BMB Reports.2024; 57(3): 161. CrossRef - Establishing molecular pathology curriculum for pathology trainees and continued medical education: a collaborative work from the Molecular Pathology Study Group of the Korean Society of Pathologists
Jiwon Koh, Ha Young Park, Jeong Mo Bae, Jun Kang, Uiju Cho, Seung Eun Lee, Haeyoun Kang, Min Eui Hong, Jae Kyung Won, Youn-La Choi, Wan-Seop Kim, Ahwon Lee
Journal of Pathology and Translational Medicine.2023; 57(5): 265. CrossRef - Quality and Quantity of Nucleic Acids Extracted from Formalin-Fixed Paraffin-Embedded Lymphoma Biopsies from Nigerian Archived Biopsy
IC Uzoma, IA Taiwo, NI Ugwu, MA Durosinmi, O Akinloye
Nigerian Journal of Clinical Practice.2023; 26(12): 1854. CrossRef - Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group
Shinkyo Yoon, Miso Kim, Yong Sang Hong, Han Sang Kim, Seung Tae Kim, Jihun Kim, Hongseok Yun, Changhoon Yoo, Hee Kyung Ahn, Hyo Song Kim, In Hee Lee, In-Ho Kim, Inkeun Park, Jae Ho Jeong, Jaekyung Cheon, Jin Won Kim, Jina Yun, Sun Min Lim, Yongjun Cha, Se
Cancer Research and Treatment.2022; 54(1): 1. CrossRef - State legislative trends related to biomarker testing
Gelareh Sadigh, Hilary Gee Goeckner, Ella A. Kazerooni, Bruce E. Johnson, Robert A. Smith, Devon V. Adams, Ruth C. Carlos
Cancer.2022; 128(15): 2865. CrossRef - Clinical Application of Next-Generation Sequencing in Patients With Breast Cancer: Real-World Data
Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Heechul Shin, Eunyoung Kang, Eun-Kyu Kim, Sejoon Lee, Ji Won Woo, Hee Young Na, Soomin Ahn, Bum-Sup Jang, In Ah Kim, So Yeon Park, Jee Hyun Kim
Journal of Breast Cancer.2022; 25(5): 366. CrossRef - Small-Cell Lung Cancer: Is the Black Box Finally Opening Up?
Birgitta I. Hiddinga, Klaas Kok
Cancers.2021; 13(2): 236. CrossRef - Real‐world utility of next‐generation sequencing for targeted gene analysis and its application to treatment in lung adenocarcinoma
Jwa Hoon Kim, Shinkyo Yoon, Dae Ho Lee, Se Jin Jang, Sung‐Min Chun, Sang‐We Kim
Cancer Medicine.2021; 10(10): 3197. CrossRef - Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase
Yuki Okawa, Nobutaka Ebata, Nayoung K.D. Kim, Masashi Fujita, Kazuhiro Maejima, Shota Sasagawa, Toru Nakamura, Woong-Yang Park, Satoshi Hirano, Hidewaki Nakagawa
Oncotarget.2021; 12(15): 1540. CrossRef - Development and Validation of Targeted Gene Sequencing Panel Based Companion Diagnostic for Korean Patients with Solid Tumors
Byung-Joo Min, Woo Seung Lee, Myung-Eui Seo, Kye-Hwa Lee, Seung-Yong Jeong, Ja-Lok Ku, Yeul Hong Kim, Sang-Won Shin, Ju Han Kim
Cancers.2021; 13(20): 5112. CrossRef - Junction Location Identifier (JuLI)
Hyun-Tae Shin, Nayoung K.D. Kim, Jae Won Yun, Boram Lee, Sungkyu Kyung, Ki-Wook Lee, Daeun Ryu, Jinho Kim, Joon Seol Bae, Donghyun Park, Yoon-La Choi, Se-Hoon Lee, Myung-Ju Ahn, Keunchil Park, Woong-Yang Park
The Journal of Molecular Diagnostics.2020; 22(3): 304. CrossRef - Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults
Tomoko Watanabe, Takayuki Honda, Hirohiko Totsuka, Masayuki Yoshida, Maki Tanioka, Kouya Shiraishi, Yoko Shimada, Eri Arai, Mineko Ushiama, Kenji Tamura, Teruhiko Yoshida, Yae Kanai, Takashi Kohno
Breast Cancer Research and Treatment.2020; 182(2): 491. CrossRef
- Real-World Data and Clinical Implications of Next-Generation Sequencing (NGS)-Based Analysis in Metastatic Breast Cancer Patients
- 14,321 View
- 467 Download
- 14 Web of Science
- 13 Crossref
- Effect of Adjuvant Chemotherapy after Complete Resection for Pathologic Stage IB Lung Adenocarcinoma in High-Risk Patients as Defined by a New Recurrence Risk Scoring Model
- Hyo Joon Jang, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Hee Chul Yang, Dong Kwan Kim
- Cancer Res Treat. 2017;49(4):898-905. Published online January 18, 2017
- DOI: https://doi.org/10.4143/crt.2016.312
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Abstract
PDFPubReaderePub
- Purpose
We conducted a retrospective analysis to determine if adjuvant chemotherapy prolongs overall survival in patients with pathologic stage IB lung adenocarcinoma who had undergone complete resection and were defined as high-risk by a newly developed recurrence risk scoring model.
Materials and Methods
Patientswho underwent curative resection for stage IB lung adenocarcinomawere analyzed with a newly developed recurrence risk scoring model and divided into a low-risk group and a high-risk group. The patients in the high-risk group were retrospectively divided into two groups based on whether they underwent adjuvant chemotherapy or observation. Recurrence-free survival and overall survival were compared between these two groups.
Results
A total of 328 patients who underwent curative resection between 2000 and 2009 were included in this study, of whom 110 (34%) received adjuvant chemotherapy and 218 (67%) underwent observation without additional treatment. According to our risk model, 167 patients (51%) were high-risk and 161 (49%) were low-risk. The 5-year recurrence-free survival rates and overall survival were 84.4% and 91.5% in low-risk patients and 53.9% and 74.7% in high-risk patients (p < 0.001). In high-risk patients, the 5-year overall survival rates were 77% among patients who underwent observation and 87% among those who underwent adjuvant chemotherapy (p=0.019).
Conclusion
Adjuvant chemotherapy prolonged overall survival among high-risk patients who had undergone complete resection for stage IB lung adenocarcinoma. -
Citations
Citations to this article as recorded by- Influence of adjuvant chemotherapy on survival for patients with completely resected high-risk stage IB NSCLC
Zi-Qing Shen, Kun-Peng Feng, Zi-Yao Fang, Tian Xia, Shu Pan, Cheng Ding, Chun Xu, Sheng Ju, Jun Chen, Chang Li, Jun Zhao
Journal of Cardiothoracic Surgery.2024;[Epub] CrossRef - Surgically Treated pT2aN0M0 (Stage IB) Non-Small Cell Lung Cancer: A 20-Year Single-Center Retrospective Study
Monica Casiraghi, Francesco Petrella, Claudia Bardoni, Shehab Mohamed, Giulia Sedda, Juliana Guarize, Antonio Passaro, Filippo De Marinis, Patrick Maisonneuve, Lorenzo Spaggiari
Journal of Clinical Medicine.2023; 12(5): 2081. CrossRef - A Novel Nomogram for Identifying Candidates for Adjuvant Chemotherapy in Patients With Stage IB Non-small Cell Lung Cancer
Xue Song, Yangyang Xie, Haoran Deng, Fei Yu, Shiqiang Wang, Yafang Lou
Cancer Control.2023;[Epub] CrossRef - Adjuvant chemotherapy may improve long-term outcomes in stage IB non-small cell lung cancer patients with previous malignancies: A propensity score-matched analysis
Ke Zhou, Yaqin Zhao, Linchuan Liang, Jie Cao, Huahang Lin, Zhiyu Peng, Jiandong Mei
Frontiers in Oncology.2022;[Epub] CrossRef - A Population-Based Study on the Prognostic factors and Efficacy of Adjuvant Chemotherapy in the Postoperative Stage for Patients with Stage IIA Non-Small Cell Lung Cancer
Wei Wang, Fei Teng, Shi Bu, Wei Xu, Qing-Chun Cai, Yue-Quan Jiang, Zhi-Qiang Wang
Risk Management and Healthcare Policy.2022; Volume 15: 1581. CrossRef - Personalized Prescription of Chemotherapy Based on Assessment of mRNA Expression of BRCA1, RRM1, ERCC1, TOP1, TOP2α, TUBβ3, TYMS, and GSTP1 Genes in Tumors Compared to Standard Chemotherapy in the Treatment of Non-Small-Cell Lung Cancer
Matvey M. Tsyganov, Evgeny O. Rodionov, Marina K. Ibragimova, Sergey V. Miller, Olga V. Cheremisina, Irina G. Frolova, Sergey A. Tuzikov, Nikolai V. Litviakov
Journal of Personalized Medicine.2022; 12(10): 1647. CrossRef - Survival Nomogram for Stage IB Non-Small-Cell Lung Cancer Patients, Based on the SEER Database and an External Validation Cohort
Zhichao Zuo, Guochao Zhang, Peng Song, Jing Yang, Shuiting Li, Zhi Zhong, Qinghao Tan, Liming Wang, Qi Xue, Shugeng Gao, Nan Sun, Jie He
Annals of Surgical Oncology.2021; 28(7): 3941. CrossRef - Drug Regimen for Patients after a Pneumonectomy
Noheul Kim, Ronny Priefer
Journal of Respiration.2021; 1(2): 114. CrossRef - Prognostic stratification of pathological node-negative lung adenocarcinoma by carcinoembryonic antigen level
Khashchuluun Batmunkh, Sukki Cho, Sungwon Yum, Kwhanmien Kim, Sanghoon Jheon
Interactive CardioVascular and Thoracic Surgery.2020; 30(6): 820. CrossRef - Effects of adjuvant chemotherapy on survival of patients with stage IB non-small cell lung cancer with visceral pleural invasion
Jun Xie, Xian Zhang, Song Hu, Wan-Da Peng, Bin Xu, Yan Li, Su-Juan Zhang, Qing Li, Chong Li
Journal of Cancer Research and Clinical Oncology.2020; 146(9): 2231. CrossRef
- Influence of adjuvant chemotherapy on survival for patients with completely resected high-risk stage IB NSCLC
- 8,410 View
- 187 Download
- 12 Web of Science
- 10 Crossref
- Curative Resection for Metachronous Pulmonary Metastases from Colorectal Cancer: Analysis of Survival Rates and Prognostic Factors
- Myong Hoon Ihn, Duck-Woo Kim, Sukki Cho, Heung-Kwon Oh, Sanghoon Jheon, Kwhanmien Kim, Eun Shin, Hye Seung Lee, Jin-Haeng Chung, Sung-Bum Kang
- Cancer Res Treat. 2017;49(1):104-115. Published online May 9, 2016
- DOI: https://doi.org/10.4143/crt.2015.367
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Abstract
PDFPubReaderePub
- Purpose
Prognostic factors in patients with pulmonary metastases (PM) from colorectal cancer (CRC) are still controversial. This study assessed oncologic outcomes and prognostic factors in patients with metachronous PM from CRC.
Materials and Methods
Between June 2003 and December 2011, 122 patients with CRC underwent curative resection of PM detected at least 4 months after CRC resection. Clinico-pathological factors selected from the prospectively maintained database were analyzed retrospectively.
Results
The median disease-free interval (DFI) between resection of the primary tumor and detection of PM was 22.0 months (range, 4 to 85 months). Solitary PM were detected in 77 patients (63.1%), with a median maximal tumor diameter of 12.0 mm (range, 2 to 70 mm). Of 52 patients who underwent mediastinal lymph node (LN) dissection, eight patients had LN involvement. Five-year overall survival and disease-free survival (DFS) rates after initial pulmonary metastasectomy were 66.4% and 50.9%, respectively. DFI, mediastinal LN involvement, and the number and distribution of PM were significantly prognostic factors for DFS. In multivariable analysis DFI ≥ 12 months, solitary lesion, and absence of mediastinal LN involvement were independently prognostic for DFS. Of the 122 patients, 48 patients (39.3%) developed recurrent PM a median 13.0 months after initial pulmonary metastasectomy. Recurrent DFI was independently prognostic of DFS in patients who underwent repeated pulmonary metastasectomy.
Conclusion
There is a potential survival benefit for patients with metachronous PM from CRC who undergo pulmonary metastasectomy, even those with recurrent PM. Pulmonary metastasectomy should be considered in selected patients, particularly those with longer DFI, solitary lesions, and absence of mediastinal LN involvement. -
Citations
Citations to this article as recorded by- Outcomes and prognostic factors of repeat pulmonary metastasectomy
Ryu Kanzaki, Hirokazu Watari, Akiisa Omura, Sachi Kawagishi, Ryo Tanaka, Tomohiro Maniwa, Jiro Okami
Interdisciplinary CardioVascular and Thoracic Surgery.2024;[Epub] CrossRef - Development of a protocol for whole-lung in vivo lung perfusion-assisted photodynamic therapy using a porcine model
Khaled Ramadan, Tina Saeidi, Edson Brambate, Vanderlei Bagnato, Marcelo Cypel, Lothar Lilge
Journal of Biomedical Optics.2024;[Epub] CrossRef - circEIF3I Promotes Colorectal Cancer Metastasis by Regulating the miR‐328‐3p/NCAPH Axis
Yali Zhao, Yan He, Zhiyuan Xiao, Le Xin, Mingjing Deng, Mingxia Yao, Guan Huang
Molecular Carcinogenesis.2024;[Epub] CrossRef - Role of Pulmonary Metastasectomy in Colorectal Cancer
Zamaan Hooda, Michael Eisenberg, Mara B. Antonoff
Thoracic Surgery Clinics.2024;[Epub] CrossRef - Preoperative prognostic factors for 5-year survival following pulmonary metastasectomy from colorectal cancer: a systematic review and meta-analysis
Andreas Gkikas, Christos Kakos, Savvas Lampridis, Peter J Godolphin, Davide Patrini
European Journal of Cardio-Thoracic Surgery.2023;[Epub] CrossRef - FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation
Lingnan He, Zijun Guo, Weijun Wang, Shuxin Tian, Rong Lin
Cell Communication and Signaling.2023;[Epub] CrossRef - PET/MRI in colorectal and anal cancers: an update
Vetri Sudar Jayaprakasam, Semra Ince, Garima Suman, Pankaj Nepal, Thomas A. Hope, Raj Mohan Paspulati, Tyler J. Fraum
Abdominal Radiology.2023; 48(12): 3558. CrossRef - A review of surgery for lung metastasis from colorectal cancer
Yu-Kwang Lee, Mong-Wei Lin, Ke-Cheng Chen, Pei-Ming Huang, Shuenn-Wen Kuo, Jang-Ming Lee
Formosan Journal of Surgery.2023;[Epub] CrossRef - Long-term outcomes and early recurrence after resection for metachronous pulmonary metastases from colorectal cancer
Shintaro Hashimoto, Tetsuro Tominaga, Takashi Nonaka, Keisuke Noda, Soishiro Kiya, Toshio Shiraishi, Kaido Oishi, Yuma Takamura, Shoto Yamazaki, Masato Araki, Yorihisa Sumida, Takuro Miyazaki, Ryotaro Kamohara, Shigeyuki Morino, Keitaro Matsumoto, Akihiro
Langenbeck's Archives of Surgery.2023;[Epub] CrossRef - Survival and prognostic factors of isolated pulmonary metastases originating from colorectal cancer: An 8-year single-center experience
Ameera S. Balhareth, Abdullah S. AlQattan, Hassan M. Alshaqaq, Abdullah M. Alkhalifa, Alaa A. Al Abdrabalnabi, Muna S. Alnamlah, Deborah MacNamara
Annals of Medicine and Surgery.2022; 77: 103559. CrossRef - Long term survival after multiple microwave ablations for colorectal cancer lung metastases: A case report
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