Cancer Research and Treatment

Special Articles

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2018: Seri Hong, Young-Joo Won, Jae Jun Lee, Kyu-Won Jung, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo, The Community of Population-Based Regional Cancer Registries; Cancer Res Treat. 2021;53(2):301-315. Published online March 17, 2021; DOI: https://doi.org/10.4143/crt.2021.291

Abstract PDF Supplementary Material PubReader ePub

Purpose
The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2018.
Materials and Methods
Incidence, survival, and prevalence rates of cancer were calculated using the Korea National Cancer Incidence Database, from 1999 to 2018, with survival follow-up until December 31, 2019. Deaths from cancer were assessed using causes-of-death data obtained from Statistics Korea. Crude and age-standardized rates (ASRs) for incidence, mortality, prevalence, and 5-year relative survival rates were calculated, and temporal trends for incidence and mortality rates were evaluated, with annual percentage changes.
Results
In 2018, newly diagnosed cancer cases and deaths from cancer were reported as 243,837 (ASR, 270.4 per 100,000) and 79,153 (ASR, 73.3 per 100,000), respectively. The overall cancer incidence rates increased by 3.3% annually from 1999 to 2012, and decreased by 5.4% annually from 2012 to 2015, thereafter, followed by nonsignificant changes. Cancer mortality rates have been decreasing since 2002, with more rapid decline in recent years (annual decrease of 2.7% from 2007 to 2014; 3.7% from 2014 to 2018). The 5-year relative survival between 2014 and 2018 was 70.3%, which contributed to prevalent cases reaching over 2 million by the end of 2018.
Conclusion
Cancer statistics have improved significantly during the past two decades. However, there remain important challenges to be solved, such as controlling cancers with low survival rates. Cancer statistics can be used to discover blind spots in cancer control, and as evidence for developing and implementing future cancer control strategies.

Citations

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Tobacco Induced Diseases.2023; 21(May): 1. CrossRef
Recent Trends of Medical Expenses Associated with Radiation Therapy in Korea Based on HIRA Big Data
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Cancer Research and Treatment.2023; 55(3): 758. CrossRef
Asia‐Pacific Leukemia Consortium: An innovative and collaborative initiative to improve care of leukemia and related diseases in the Asia‐Pacific region
Zhentang Lao, Eric Wai Choi Tse, Suporn Chuncharunee, Yok Lam Kwong, Andrew Wei, Bor Sheng Ko, Jin Seok Kim, Soo Chin Ng, Jianxiang Wang, Yeow Tee Goh
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Survival rate of thyroid cancer in the Asian countries: a systematic review and meta-analysis study
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Endocrine.2023; 82(2): 237. CrossRef
Effects of prior endoscopic resection on recurrence in patients with T1 colorectal cancer who underwent radical surgery
Hyun Jin Joo, Jee Ung Seok, Byung Chang Kim, Dong-eun Lee, Bun Kim, Kyung Su Han, Chang Won Hong, Dae Kyung Sohn, Dong Woon Lee, Sung Chan Park, Hee Jin Chang, Jae Hwan Oh
International Journal of Colorectal Disease.2023;[Epub] CrossRef
Etiology of Isolated Third, Fourth, and Sixth Cranial Nerve Palsies with a Cancer History
Dongyoung Lee, Kyung-Ah Park
Journal of the Korean Ophthalmological Society.2023; 64(6): 532. CrossRef
Testicular Cancer Incidence among Obstructive Sleep Apnea (OSA) Patients: South Korean National Health Insurance Data
Marn Joon Park, Kyung-Do Han, Jae Hoon Cho, Ji Ho Choi
Cancers.2023; 15(13): 3273. CrossRef
Differential Prognostic Value of Vascular Invasion in Resected Lung Adenocarcinomas According to Epidermal Growth Factor Receptor Mutational Status
Kyung Hee Lee, Jin-Haeng Chung, Sukki Cho, Jong-Seok Lee, Hyungjin Kim
Clinical Lung Cancer.2023; 24(7): e291. CrossRef
Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population
Anh Quynh Bui, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Scientific Reports.2023;[Epub] CrossRef
Sex‐specific differences in colorectal cancer: A multicenter retrospective cohort study
Hyun Jin Joo, Hyun Seok Lee, Byung Ik Jang, Dae Bum Kim, Jae Hyun Kim, Jae Jun Park, Hyun Gun Kim, Il Hyun Baek, Jun Lee, Bun Kim
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Computed Tomography–based Prognostication in Lung Adenocarcinomas through Histopathological Feature Learning: A Retrospective Multicenter Study
Kyung Hee Lee, Jong Hyuk Lee, Samina Park, Yoon Kyung Jeon, Doo Hyun Chung, Young Tae Kim, Jin Mo Goo, Hyungjin Kim
Annals of the American Thoracic Society.2023; 20(7): 1020. CrossRef
Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
Jaesung Choi, JooYong Park, Ji-Eun Kim, Miyoung Lee, Daehee Kang, Aesun Shin, Ji-Yeob Choi
Cancer Prevention Research.2023; 16(7): 405. CrossRef
Preferred versus Actual Place of Care and Factors Associated with Home Discharge among Korean Patients with Advanced Cancer: A Retrospective Cohort Study
In Young Hwang, Yohan Han, Min Sun Kim, Kyae Hyung Kim, Belong Cho, Wonho Choi, Yejin Kim, Shin Hye Yoo, Sun Young Lee
Healthcare.2023; 11(13): 1939. CrossRef
Systematic Review of Lung Cancer Screening: Advancements and Strategies for Implementation
Daniela Amicizia, Maria Francesca Piazza, Francesca Marchini, Matteo Astengo, Federico Grammatico, Alberto Battaglini, Irene Schenone, Camilla Sticchi, Rosa Lavieri, Bruno Di Silverio, Giovanni Battista Andreoli, Filippo Ansaldi
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Trends in incidence and overdiagnosis of thyroid cancer in China, Japan, and South Korea
Yongtian Lin, Yu Wu
Cancer Science.2023; 114(10): 4052. CrossRef
Complication After Gastrectomy for Gastric Cancer According to Hospital Volume: Based on Korean Gastric Cancer Association-Led Nationwide Survey Data
Sang-Ho Jeong, Moon-Won Yoo, Miyeong Park, Kyung Won Seo, Jae-Seok Min
Journal of Gastric Cancer.2023; 23(3): 462. CrossRef
Renal function change after radical cystectomy for urothelial carcinoma patients with a solitary kidney may be independent of urinary diversion type
Gyeong Hun Kim, Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Ja Hyeon Ku
Investigative and Clinical Urology.2023; 64(5): 457. CrossRef
Serum 25-Hydroxyvitamin D Levels and Risk of Colorectal Cancer: An Age-Stratified Analysis
Yejin Kim, Yoosoo Chang, Yoosun Cho, Jiwon Chang, Kyungeun Kim, Dong-Il Park, Soo-Kyung Park, Hee-Kyung Joh, Mi Kyung Kim, Chanmin Kim, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Gastroenterology.2023; 165(4): 920. CrossRef
Comparison of the Effects of DOTA and NOTA Chelators on 64Cu-Cudotadipep and 64Cu-Cunotadipep for Prostate Cancer
Inki Lee, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Jae Hun Ahn, Yong Jin Lee, Gi Jeong Cheon, Dae Yoon Chi, Sang Moo Lim
Diagnostics.2023; 13(16): 2649. CrossRef
Combinations of lifestyle behaviors and cancer risk among Korean adults
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Scientific Reports.2023;[Epub] CrossRef
Prognostic value of CT-defined ground-glass opacity in early-stage lung adenocarcinomas: a single-center study and meta-analysis
Jong Hyuk Lee, Yunhee Choi, Hyunsook Hong, Young Tae Kim, Jin Mo Goo, Hyungjin Kim
European Radiology.2023; 34(3): 1905. CrossRef
Prognostic Value of Hematological Markers in Head and Neck Cancer Patients With a History of Hematological Malignancy
Jooin Bang, Oh-Hyeong Lee, Geun-Jeon Kim, Sang-Yeon Kim, Dong-Il Sun
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(10): 678. CrossRef
Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer
Hwa Kyung Park, Chang-Seok Yoon, Young-Ok Na, Jae-Kyeong Lee, Hyung-Joo Oh, Ha-Young Park, Bo-Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Yong-Soo Kwon, In-Jae Oh, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, Cheol-Kyu Park
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Sublobar Resection versus Stereotactic Body Radiation Therapy for Clinical Stage I Non–Small Cell Lung Cancer: A Study Using Data from the Korean Nationwide Lung Cancer Registry
Jeonghee Yun, Jong Ho Cho, Tae Hee Hong, Kyungmi Yang, Yong Chan Ahn, Hong Kwan Kim
Cancer Research and Treatment.2023; 55(4): 1171. CrossRef
Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort
Chi Lan Tran, Minji Han, Byungmi Kim, Eun Young Park, Young Il Kim, Jin‐Kyoung Oh
Cancer Medicine.2023; 12(18): 19163. CrossRef
Short-term efficacy of additional laparoscopic-assisted radical gastrectomy after non-curative endoscopic submucosal dissection for early gastric cancer
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A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10)
Keun-Wook Lee, Dae Young Zang, Min-Hee Ryu, Hye Sook Han, Ki Hyang Kim, Mi-Jung Kim, Sung Ae Koh, Sung Sook Lee, Dong-Hoe Koo, Yoon Ho Ko, Byeong Seok Sohn, Jin Won Kim, Jin Hyun Park, Byung-Ho Nam, In Sil Choi
Cancer Research and Treatment.2023; 55(4): 1250. CrossRef
Preoperative Haematologic Markers for the Differentiation of Endometrial Cancer from Benign Endometrial Lesions in Postmenopausal Patients with Endometrial Masses
Yong Jung Song, Hwi Gon Kim, Hyung Joon Yoon, Kyung Un Choi, Dong Soo Suh, Ki Hyung Kim
Cancer Management and Research.2023; Volume 15: 1111. CrossRef
Enhanced Risk Stratification in Early-Stage Endometrial Cancer: Integrating POLE through Droplet Digital PCR and L1CAM
Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee
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Diagnostic performance and prognostic value of CT-defined visceral pleural invasion in early-stage lung adenocarcinomas
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European Radiology.2023; 34(3): 1934. CrossRef
Prognostication of lung adenocarcinomas using CT-based deep learning of morphological and histopathological features: a retrospective dual-institutional study
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European Radiology.2023; 34(5): 3431. CrossRef
Gastric Cancer Incidence and Mortality After Endoscopic Resection of Gastric Adenoma: A Nationwide Cohort Study
Jae Myung Park, Songhee Cho, Ga-Yeong Shin, Jayoun Lee, Minjee Kim, Hyeon Woo Yim
American Journal of Gastroenterology.2023; 118(12): 2166. CrossRef
Comparison of complications between laparoscopic and open gastrectomies for early gastric cancer by a nationwide propensity score-matched cohort study
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Comparative Risk of Type 2 Diabetes after Gastrectomy and Endoscopic Resection for Gastric Cancer: A Nationwide Cohort Study
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Journal of the American College of Surgeons.2023; 237(6): 902. CrossRef
Mammographic Breast Density and Risk of Ovarian Cancer in Korean Women
Thi Xuan Mai Tran, Soyeoun Kim, Boyoung Park
Cancer Epidemiology, Biomarkers & Prevention.2023; 32(12): 1690. CrossRef
Deep learning-based prognostication in idiopathic pulmonary fibrosis using chest radiographs
Taehee Lee, Su Yeon Ahn, Jihang Kim, Jong Sun Park, Byoung Soo Kwon, Sun Mi Choi, Jin Mo Goo, Chang Min Park, Ju Gang Nam
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How should the healthcare system support cancer survivors? Survivors’ and health professionals’ expectations and perception on comprehensive cancer survivorship care in Korea: a qualitative study
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BMC Cancer.2023;[Epub] CrossRef
Parental intention to vaccinate daughters with the human papillomavirus vaccine in Korea: a nationwide cross-sectional survey
Yejin Ha, Kyeongmin Lee, Bomi Park, Mina Suh, Jae Kwan Jun, Kui Son Choi
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Socioeconomic inequality in organized and opportunistic screening for colorectal cancer: results from the Korean National Cancer Screening Survey, 2009-2021
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kui Son Choi
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Riboflavin intake, MTRR genetic polymorphism (rs1532268) and gastric cancer risk in a Korean population: a case–control study
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2022; 127(7): 1026. CrossRef
Cause-specific mortality rate of ovarian cancer in the presence of competing risks of death: a nationwide population-based cohort study
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Association between metabolic syndrome and its components and incident colorectal cancer in a prospective cohort study
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Cancer.2022; 128(6): 1230. CrossRef
Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study
Eunji Kim, Tae Hyung Kim, Wonguen Jung, Kyubo Kim, Ah Ram Chang, Hae Jin Park, Hyeon Kang Koh, Semie Hong, Kyung Hwan Kim, Jee Suk Chang, Woong Sub Koom, Won Il Jang, Mi-Sook Kim
International Journal of Clinical Oncology.2022; 27(3): 553. CrossRef
Body Mass Index and Thyroid Cancer Risk: A Pooled Analysis of Half a Million Men and Women in the Asia Cohort Consortium
Aesun Shin, Sooyoung Cho, Doeun Jang, Sarah Krull Abe, Eiko Saito, Md Shafiur Rahman, Md Rashedul Islam, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Yumi Sugawara, Hidemi Ito, Chisato Nagata, Sue K. Park, Jian-Min Yuan, Jeongs
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Cervical conization before primary radical hysterectomy has a protective effect on disease recurrence in early cervical cancer: A two-center matched cohort study according to surgical approach
Se Ik Kim, Bo Ram Choi, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Chel Hun Choi, Maria Lee
Gynecologic Oncology.2022; 164(3): 535. CrossRef
Influence of Fasting Glucose Level on Gastric Cancer Incidence in a Prospective Cohort Study
Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Hyunsoon Cho, Jeongseon Kim
Cancer Epidemiology, Biomarkers & Prevention.2022; 31(1): 254. CrossRef
Spade-Shaped Anastomosis after Laparoscopic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomach (SPADE Operation): A Case Series
Sin Hye Park, Harbi Khalayleh, Sung Gon Kim, Sang Soo Eom, Fahed Merei, Junsun Ryu, Young-Woo Kim
Cancers.2022; 14(2): 379. CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Population attributable fractions of modifiable cancer risk factors in Korea: a systematic review protocol
Mi Ah Han, Eu Chang Hwang, Jae Hung Jung, Seo-Hee Kim, Sun Mi Park
BMJ Open.2022; 12(1): e055758. CrossRef
The incidence and clinical features of familial pancreatic cancer in Korea
Minseob Kim, Hongbeom Kim, Youngmin Han, Heeju Sohn, Mirang Lee, Yoon Hyung Kang, Hyeong Seok Kim, Wooil Kwon, Jin‐Young Jang
Journal of Hepato-Biliary-Pancreatic Sciences.2022; 29(6): 659. CrossRef
Neoadjuvant chemotherapy with gemcitabine and cisplatin followed by selective bladder preservation chemoradiotherapy in muscle-invasive urothelial carcinoma of bladder
Hyun Hwan Sung, Hana Kim, Ryul Kim, Chan Kyo Kim, Ghee Young Kwon, Won Park, Wan Song, Byong Chang Jeong, Se Hoon Park
Investigative and Clinical Urology.2022; 63(2): 168. CrossRef
Effect of colorectal cancer screening on long‐term survival of colorectal cancer patients: Results of the Korea National Cancer Screening Program
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu‐Won Jung, Kui Son Choi
International Journal of Cancer.2022; 150(12): 1958. CrossRef
Conditional relative survival of patients with endometrial cancer: a Korean National Cancer Registry study
Dong Wook Shin, Kyu-Won Jung, Johyun Ha, Jaeman Bae
Journal of Gynecologic Oncology.2022;[Epub] CrossRef
Trends in cervical cancer screening rates among Korean women: results of the Korean National Cancer Screening Survey, 2005–2020
Hye Young Shin, Yun Yeong Lee, Soo Yeon Song, Bomi Park, Mina Suh, Kui Son Choi, Jae Kwan Jun
Journal of Gynecologic Oncology.2022;[Epub] CrossRef
The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
European Journal of Nutrition.2022; 61(5): 2601. CrossRef
Coffee consumption and its interaction with the genetic variant AhR rs2066853 in colorectal cancer risk: a case–control study in Korea
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Youngyo Kim, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Carcinogenesis.2022; 43(3): 203. CrossRef
Trends in Incidence and Survival of Patients With Thymic Epithelial Tumor in a High-Incidence Asian Country: Analysis of the Korean Central Cancer Registry 1999 to 2017
Dong Wook Shin, Jong Ho Cho, Johyun Ha, Kyu-Won Jung
Journal of Thoracic Oncology.2022; 17(6): 827. CrossRef
No Prognostic Impact of Staging Brain MRI in Patients with Stage IA Non–Small Cell Lung Cancer
Ju G. Nam, Hyunsook Hong, Seung Hong Choi, Chang Min Park, Jin Mo Goo, Young Tae Kim, Hyungjin Kim
Radiology.2022; 303(3): 632. CrossRef
Notification of Terminal Status and Advance Care Planning in Patients with Cancer
Si Won Lee
The Korean Journal of Hospice and Palliative Care.2022; 25(1): 42. CrossRef
Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Current Issues in Molecular Biology.2022; 44(3): 1395. CrossRef
Assessment of textbook outcome after lobectomy for early‐stage non‐small cell lung cancer in a Korean institution: A retrospective study
Woo Sik Yu, Jaeyong Shin, Jung A Son, Joonho Jung, Seokjin Haam
Thoracic Cancer.2022; 13(8): 1211. CrossRef
Comparison of the Clinical Outcomes of Reconstruction Methods After Distal Gastrectomy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials
Jae-Seok Min, Rock Bum Kim, Kyung Won Seo, Sang-Ho Jeong
Journal of Gastric Cancer.2022; 22(2): 83. CrossRef
PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
Ick Joon Cho, Jae-Uk Jeong, Taek-Keun Nam, Young-Eun Joo, Sung-Bum Cho, Yong-Hyub Kim, Ju-Young Song, Mee Sun Yoon, Sung-Ja Ahn, Woong-Ki Chung
Radiation Oncology Journal.2022; 40(1): 20. CrossRef
Chronic pancreatitis and cancer risk in a matched cohort study using national claims data in South Korea
Minji Han, Thi Phuong Thao Tran, Jin-Kyoung Oh
Scientific Reports.2022;[Epub] CrossRef
Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea
Se Ik Kim, Hyeong In Ha, Kyung Jin Eoh, Jiwon Lim, Young-Joo Won, Myong Cheol Lim
Frontiers in Oncology.2022;[Epub] CrossRef
Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Rectal Cancer: Long-Term Results after Protocol-Based Treatment
Dong Soo Lee, Seong-Taek Oh, Chang-Hyeok Ahn, Jaeim Lee, Kil-Yong Lee, Hiun Suk Chae, Sung Soo Kim, Sang Woo Kim, Kyung Jin Seo, Alessandro Granito
Journal of Oncology.2022; 2022: 1. CrossRef
Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter?
Hyeji Kim, Hyungju Kwon, Byung-In Moon
Cancers.2022; 14(8): 1896. CrossRef
Prediction of Cancer Incidence and Mortality in Korea, 2022
Kyu-Won Jung, Young-Joo Won, Mee Joo Kang, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
Cancer Research and Treatment.2022; 54(2): 345. CrossRef
Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection
Jiyoung Yoon, Seung-Yeon Yoo, Young Soo Park, Kee Don Choi, Beom Su Kim, Moon-Won Yoo, In Seob Lee, Jeong Hwan Yook, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
World Journal of Gastroenterology.2022; 28(15): 1548. CrossRef
Exploring socio-demographic, physical, psychological, and quality of life-related factors related with fear of cancer recurrence in stomach cancer survivors: a cross-sectional study
Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, JiHye Hwang, Ji Eun Lee, BeLong Cho, Yun–Mi Song
BMC Cancer.2022;[Epub] CrossRef
Single-Center Real-World Experience of Multiple Myeloma in the 21st Century
Hyungwoo Cho, Shin Kim, Kyoungmin Lee, Eun Hee Kang, Jung Sun Park, Cheolwon Suh
The Korean Journal of Medicine.2022; 97(2): 125. CrossRef
Nanocarrier-based co-delivery approaches of chemotherapeutics with natural P-glycoprotein inhibitors in the improvement of multidrug resistance cancer therapy
Shadab Md, Nabil A. Alhakamy, Priyanka Sharma, Mohammad Shahnawaze Ansari, Bapi Gorain
Journal of Drug Targeting.2022; 30(8): 801. CrossRef
Association of institutional transition of cancer care with mortality in elderly patients with lung cancer: a retrospective cohort study using national claim data
Kyu-Tae Han, Jongwha Chang, Dong-Woo Choi, Seungju Kim, Dong Jun Kim, Yoon-Jung Chang, Sun Jung Kim
BMC Cancer.2022;[Epub] CrossRef
Staging and response assessment of lymphoma: a brief review of the Lugano classification and the role of FDG-PET/CT
Kwai Han Yoo
Blood Research.2022; 57(S1): S75. CrossRef
Association between Low-Dose Computed Tomography Results and 1-Year Smoking Cessation in a Residential Smoking Cessation Program
Da-Som Shin, Hye-Mi Noh, Hong Ji Song, Kyung Hee Park, Young-Gyun Seo, Yu-Jin Paek
International Journal of Environmental Research and Public Health.2022; 19(9): 5510. CrossRef
Distress, Family Resilience, and Quality of Life among Family Caregivers of Cancer Patients Undergoing Chemotherapy: The Moderating Role of Family Resilience
Son-Hee Ahn, Soo Hyun Kim
Korean Journal of Adult Nursing.2022; 34(2): 225. CrossRef
Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab
Kyunghye Bang, Jaekyung Cheon, Young Soo Park, Hyung-Don Kim, Min-Hee Ryu, Yangsoon Park, Meesun Moon, Hyungeun Lee, Yoon-Koo Kang
Gastric Cancer.2022; 25(4): 794. CrossRef
Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Journal of Gastroenterology.2022; 57(7): 464. CrossRef
The Associations of Dietary Intake of High Sodium and Low Zinc with Gastric Cancer Mortality: A Prospective Cohort Study in Korea
Jung Hyun Kwak, Chan Hyuk Park, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Nutrition and Cancer.2022; 74(10): 3501. CrossRef
Development of Korean CARcinogen EXposure: Assessment of the Exposure Intensity of Carcinogens by Industry
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Hyejung Jung, Inah Kim, Sangjun Choi, Donguk Park
Safety and Health at Work.2022; 13(3): 308. CrossRef
Natural Language Processing for Information Extraction of Gastric Diseases and Its Application in Large-Scale Clinical Research
Gyuseon Song, Su Jin Chung, Ji Yeon Seo, Sun Young Yang, Eun Hyo Jin, Goh Eun Chung, Sung Ryul Shim, Soonok Sa, Moongi Simon Hong, Kang Hyun Kim, Eunchan Jang, Chae Won Lee, Jung Ho Bae, Hyun Wook Han
Journal of Clinical Medicine.2022; 11(11): 2967. CrossRef
Current status of the gastric cancer screening program in Korea
Young-Il Kim, Il Ju Choi
Journal of the Korean Medical Association.2022; 65(5): 250. CrossRef
Association between Dietary Fiber Intake and Colorectal Adenoma
Hyojin Kim, Jiyoung Youn, Sun Young Yang, Ji Hyun Song, Young Sun Kim, Jung Eun Lee
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Deep Learning Prediction of Survival in Patients with Chronic Obstructive Pulmonary Disease Using Chest Radiographs
Ju Gang Nam, Hye-Rin Kang, Sang Min Lee, Hyungjin Kim, Chanyoung Rhee, Jin Mo Goo, Yeon-Mok Oh, Chang-Hoon Lee, Chang Min Park
Radiology.2022; 305(1): 199. CrossRef
Clinical Implication of Preoperative Renal Function on Oncological Outcomes in Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy
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Biomedicines.2022; 10(6): 1340. CrossRef
Recent Improvements in the Treatment of High-Risk Thyroid Cancer
Eun Kyung Lee
Korean Society for Head and Neck Oncology.2022; 38(1): 1. CrossRef
Association between Masticatory Difficulty and Handgrip Strength in Korean Adult Cancer Survivors
Geon Jung, Ga Eun Nam, Youn Huh, Yusun Her, Eun Sik Lee, Jeemin Choo, Jinkyung Chang, Yang-Hyun Kim, Kyung-Hwan Cho
Korean Journal of Family Practice.2022; 12(3): 179. CrossRef
Retreatment with progestin for recurrence after complete response with fertility-sparing treatment in patients with endometrial cancer
A Jin Lee, Seung-Hyuk Shim, Nae Ry Kim, Eun Jung Yang, Kyeong A So, Sun Joo Lee, Ji Young Lee, Tae Jin Kim, Soon-Beom Kang
International Journal of Gynecological Cancer.2022; 32(8): 1001. CrossRef
Association between Micronutrient Intake and Breast Cancer Risk According to Body Mass Index in South Korean Adult Women: A Cohort Study
Huiyeon Song, Ansun Jeong, Thi Xuan Mai Tran, Jiseon Lee, Mikyung Kim, Boyoung Park
Nutrients.2022; 14(13): 2644. CrossRef
Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019
Juhee Park, Kyeongjun Moon, Dong-Sook Kim
Frontiers in Oncology.2022;[Epub] CrossRef
Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study
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Association between dietary intake networks identified through a Gaussian graphical model and the risk of cancer: a prospective cohort study
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European Journal of Nutrition.2022; 61(8): 3943. CrossRef
Cancer Incidence and Mortality in Asian Countries: A Trend Analysis
Junjie Huang, Chun Ho Ngai, Yunyang Deng, Man Sing Tin, Veeleah Lok, Lin Zhang, Jinqiu Yuan, Wanghong Xu, Zhi-Jie Zheng, Martin C. S. Wong
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Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis
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Technology in Cancer Research & Treatment.2022;[Epub] CrossRef
High Expression of PRNP Predicts Poor Prognosis in Korean Patients with Gastric Cancer
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Prediction of Cancer Incidence and Mortality in Korea, 2021: Kyu-Won Jung, Young-Joo Won, Seri Hong, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo; Cancer Res Treat. 2021;53(2):316-322. Published online March 17, 2021; DOI: https://doi.org/10.4143/crt.2021.290

Abstract PDF PubReader ePub

Purpose
This study aimed to report the projected cancer incidence and mortality for the year 2021 to estimate Korea’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2018 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2019 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against their respective years and then by multiplying the projected age-specific rates by the anticipated age-specific population for 2021. A joinpoint regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend.
Results
In total, 259,999 new cancer cases and 81,567 cancer deaths are expected to occur in Korea in 2021. The most common cancer site is expected to be the lung, followed by the thyroid, colon and rectum, breast, and stomach. These five cancers are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer leading to death is expected to be lung cancer, followed by liver, colorectal, pancreatic, and stomach cancers.
Conclusion
The incidence rates for all types of cancer in Korea are estimated to gradually decrease. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.

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Original Article

General

Trends in Cancer Screening Rates among Korean Men and Women: Results of the Korean National Cancer Screening Survey, 2004–2018: Seri Hong, Yun Yeong Lee, Jaeho Lee, Yeol Kim, Kui Son Choi, Jae Kwan Jun, Mina Suh; Cancer Res Treat. 2021;53(2):330-338. Published online October 20, 2020; DOI: https://doi.org/10.4143/crt.2020.263

Abstract PDF Supplementary Material PubReader ePub

Purpose
The Korean National Cancer Screening Survey (KNCSS) is a nationwide annual cross-sectional survey conducted for the past 15 years. This study aimed to report trends in the overall screening rates of both organized and opportunistic cancer screening programs from 2004–2018.
Materials and Methods
KNCSS data were collected using a structured questionnaire. For five major cancers (i.e., stomach, liver, colorectal, breast, and cervical cancer), we evaluated both the lifetime screening rate and the screening rate with recommendations. The study population included men aged 40–74 years and women aged 20–74 years with no cancer histories.
Results
Screening rate with recommendations increased from 2004 annually by 4.4% and 1.5% until 2013 for stomach and liver cancers, respectively, by 4.0% until 2012 for breast cancer, and by 3.6% and 1.2% until 2014 for colorectal and cervical cancers, respectively, followed by nonsignificant trends thereafter. In 2018, screening rates with recommendations for these cancers were 72.8%, 26.2%, 63.1%, 58.4%, and 55.6%, respectively.
Conclusion
Screening rates for the five types of cancer demonstrated a marked increase between 2004 and 2018. However, many recent screening rates have been flattened with nonsignificant trends, and there are lower rates for cervical cancer screening among young age groups. Steady efforts are needed to achieve higher screening participation rates overall, especially for the cervical cancer screening of young women in their 20s.

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Special Articles

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017: Seri Hong, Young-Joo Won, Young Ran Park, Kyu-Won Jung, Hyun-Joo Kong, Eun Sook Lee, The Community of Population-Based Regional Cancer Registries; Cancer Res Treat. 2020;52(2):335-350. Published online March 16, 2020; DOI: https://doi.org/10.4143/crt.2020.206

Abstract PDF PubReader ePub

Purpose
This study reports the cancer statistics and temporal trends in Korea on a nationwide scale, including incidence, survival, prevalence, and mortality in 2017.
Materials and Methods
The incidence, survival, and prevalence rates of cancer were evaluated using data from the Korea National Cancer Incidence Database from 1999 to 2017 with follow-up until December 31, 2018. Deaths from cancer were assessed using cause-of-death data from 1983 to 2017, obtained from Statistics Korea. Crude and age-standardized rates (ASRs) for incidence, mortality, and prevalence, and 5-year relative survival rates were calculated and trend analysis was performed.
Results
In 2017, newly diagnosed cancer cases and deaths from cancer numbered 232,255 (ASR, 264.4 per 100,000) and 78,863 (ASR, 76.6 per 100,000), respectively. The overall cancer incidence rates increased annually by 3.5% from 1999 to 2011 and decreased by 2.7% annually thereafter. Cancer mortality rates have been decreasing since 2002, by 2.8% annually. The 5-year relative survival rate for all patients diagnosed with cancer between 2013 and 2017 was 70.4%, which contributed to a prevalence of approximately 1.87 million cases by the end of 2017.
Conclusion
The burden of cancer measured by incidence and mortality rates have improved in Korea, with the exception of a few particular cancers that are associated with increasing incidence or mortality rates. However, cancer prevalence is increasing rapidly, with the dramatic improvement in survival during the past several years. Comprehensive cancer control strategies and efforts should continue, based on the changes of cancer statistics.

Citations

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Differential risk of 23 site‐specific incident cancers and cancer‐related mortality among patients with metabolic dysfunction‐associated fatty liver disease: a population‐based cohort study with 9.7 million Korean subjects
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Analysis of Interaction between Twenty-Seven Pyrimidinone Derivatives with XIAP Using a Theoretical Model
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Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
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The Design of an Automatic Temperature Compensation System through Smart Heat Comparison/Judgment and Control for Stable Thermal Treatment in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Surgery
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Cost-Effectiveness of Active Surveillance Compared to Early Surgery of Small Papillary Thyroid Cancer: A Retrospective Study on a Korean Population
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Supramaximal Resection for Glioblastoma: Redefining the Extent of Resection Criteria and Its Impact on Survival
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Association Between Distress at Diagnosis and Disease-free Survival Among Patients With Resectable Colon Cancer: A Large Cohort Study
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Comparison of health literacy and health behaviors between Korean women with and without breast cancer
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Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
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Expert Opinion Survey on Proposals for Safety Management of Prescription Opioids
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Gastric cancer: A unique opportunity to shift the paradigm of cancer disparities in the United States
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The increased risk of colorectal cancer in the women who underwent hysterectomy from the South Korean National Health Insurance Database
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Anticancer Properties of Some Selected Plant Phenolic Compounds: Future Leads for Therapeutic Development
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High Expression of NRF2 and Low Expression of KEAP1 Predict Worse Survival in Patients With Operable Triple-Negative Breast Cancer
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Comparison of Clinicopathological Features and Prognosis of Mucinous Gastric Carcinoma and other Gastric Cancers: A Retrospective Study of 4,417 Patients
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The effect of the introduction of the national lung cancer screening program on short-term mortality in Korea
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Lung Cancer.2023; 186: 107412. CrossRef
Subjective perceptions of 8, 11 and 14°C chemotherapy liquid cooled gloves and socks
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Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives
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Risk Predictors of Post-Embolization Syndrome after Transarterial Chemoembolization by Sex: A Retrospective Study
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Korean Journal of Adult Nursing.2023; 35(4): 418. CrossRef
Characteristics of Defecation Function Related Quality of Life According to Cancer Location in Colorectal Cancer Survivors
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Socioeconomic Disparities in Gastric Cancer and Identification of a Single SES Variable for Predicting Risk
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Re-do Operation Using a Robotic System due to Locoregional Recurrence after Initial Thyroidectomy for Thyroid Cancer
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Dehydroevodiamine inhibits lung metastasis by suppressing survival and metastatic abilities of colorectal cancer cells
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Cause-specific mortality rate of ovarian cancer in the presence of competing risks of death: a nationwide population-based cohort study
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Comparative performance of various human papillomavirus assays available in Korea for detecting cervical intraepithelial neoplasia
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Ramucirumab plus paclitaxel as a second-line treatment in HER2-positive gastric cancer: subgroup analysis of a nationwide, real-world study in Korea (KCSG-ST19-16)
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Successful treatment of locally advanced bulky cervical cancer complicated by irreducible complete uterine prolapse
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Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients
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A Pilot Feasibility Study of a Combined Supervised- and Home-Based Exercise to Improve Cancer-Related Symptoms in 1-3 Colorectal Cancer Patients
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Exposure to Secondhand Smoke and a Tobacco-Specific Carcinogen in Non-Smokers
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Dietary methyl donor nutrients, DNA mismatch repair polymorphisms, and risk of colorectal cancer based on microsatellite instability status
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European Journal of Nutrition.2022; 61(6): 3051. CrossRef
The longitudinal effects of chronotype on chemotherapy-induced nausea and vomiting in patients with breast cancer receiving neoadjuvant chemotherapy
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Prolonged or Transition to Metabolically Unhealthy Status, Regardless of Obesity Status, Is Associated with Higher Risk of Cardiovascular Disease Incidence and Mortality in Koreans
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Global guidelines for breast cancer screening: A systematic review
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Introducing the Sanguis-Filum for Detection of Gastric Mucosal Lesions Prior to Endoscopy: A Study Protocol
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Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma
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Immune Profile of BRAF-Mutated Metastatic Colorectal Tumors with Good Prognosis after Palliative Chemotherapy
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Paradigm Shift in Prostate Cancer Diagnosis: Pre-Biopsy Prostate Magnetic Resonance Imaging and Targeted Biopsy
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Korean Journal of Radiology.2022; 23(6): 625. CrossRef
Risk factors and economic burden of postoperative anastomotic leakage related events in patients who underwent surgeries for colorectal cancer
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Factors Related to the Caregiving Burden on Families of Korean Patients With Lung Cancer
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Clinical Nursing Research.2022; 31(6): 1124. CrossRef
Growth Pattern of Hepatic Metastasis as a Prognostic Index Reflecting Liver Metastasis-Associated Survival in Breast Cancer Liver Metastasis
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Current Status of the National Health Screening Programs in South Korea
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Discovery of BRCA1/BRCA2 founder variants by haplotype analysis
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Prognostic Role of Systemic Inflammatory Markers in Patients Undergoing Surgical Resection for Oral Squamous Cell Carcinoma
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Update of the Diagnostic and Therapeutic Role of the Pelvic Lymph Node Dissection Boundaries During Radical Cystectomy in Muscle Invasive Bladder Cancer
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The Korean Journal of Urological Oncology.2022; 20(2): 71. CrossRef
Enhanced Recovery After Surgery Program for Radical Cystectomy
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Colon cancer organoids using monoclonal organoids established in four different lesions of one cancer patient reveal tumor heterogeneity and different real-time responsiveness to anti-cancer drugs
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Impact of the ACOSOG Z0011 trial on surgical practice in Asian patients: trends in axillary surgery for breast cancer from a Korean Breast Cancer Registry analysis
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Various types of reconstruction after pancreaticoduodenectomy for the patients who underwent all types of gastrectomy: a single-enter experience
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The T Category of Distal Extrahepatic Bile Duct Carcinoma
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Relationship between Health Behaviors and Metabolic Syndrome in Cancer Survivors in Korea: Korean National Health and Nutrition Examination Survey, 2013–2018
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Utility of a deep learning model and a clinical model for predicting bleeding after endoscopic submucosal dissection in patients with early gastric cancer
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Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study
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Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019
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Gynecologic cancer clinical practice guidelines in Korea and current issues
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Catching Up with the World: Pepsinogen Screening for Gastric Cancer in the United States
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Trend Analysis and Prediction of Hepatobiliary Pancreatic Cancer Incidence and Mortality in Korea
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Selection Strategies and Practical Application of BRAF V600E-Mutated Non–Small Cell Lung Carcinoma
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Trends in the Performance of the Korean National Cancer Screening Program for Gastric Cancer from 2007 to 2016
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CT-Only Radiotherapy: An Exploratory Study for Automatic Dose Prediction on Rectal Cancer Patients Via Deep Adversarial Network
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PEG‐rhG‐CSF for prophylaxis of neutropenia after chemotherapy in patients with non–small cell lung cancer: A multicenter, prospective, randomized study
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Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study
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Tearing down the barriers to exercise after mastectomy: a qualitative inquiry to facilitate exercise among breast cancer survivors
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A Comparative Analysis of Patient Satisfaction and Cosmetic Outcomes after Breast Reconstruction through BREAST-Q and the Judgment of Medical Panels: Does it Reflect Well in Terms of Aesthetics in Korean Patients?
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The Medical Needs and Characteristics of Cancer and Progressive Neurologic Disease Patients Who Use Home-Based Medical Care in Korea: A Retrospective Study for 2011-2020
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Decreased Preoperative Serum AGR as a Diagnostic Marker of Poor Prognosis after Radical Surgery of Upper Urinary Tract and Bladder Cancers from a Pooled Analysis of 9,002 Patients
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Clinical Significance of Tumor Size in Gross Extrathyroidal Extension to Strap Muscles (T3b) in Papillary Thyroid Carcinoma: Comparison with T2
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Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors
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Updated Trends in Cancer in Japan: Incidence in 1985–2015 and Mortality in 1958–2018—A Sign of Decrease in Cancer Incidence
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Comparing short-term outcomes after totally laparoscopic distal gastrectomy and laparoscopy-assisted distal gastrectomy with Billroth I anastomosis: early experience of a single institution
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Risk of female-specific cancers according to obesity and menopausal status in 2•7 million Korean women: Similar trends between Korean and Western women
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Clinical Implication of Liquid Biopsy in Colorectal Cancer Patients Treated with Metastasectomy
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Chuna Manual Therapy for Lymphedema: A Systematic Review and Meta-analysis
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Anticancer Efficacy of Nonthermal Plasma Therapy Combined with PD-L1 Antibody Conjugated Gold Nanoparticles on Oral Squamous Cell Carcinoma
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Incidence and Clinical Outcomes of Febrile Neutropenia in Adult Cancer Patients with Chemotherapy Using Korean Nationwide Health Insurance Database
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Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data
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Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View
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Factors to improve distress and fatigue in Cancer survivorship; further understanding through text analysis of interviews by machine learning
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Changes in Korean National Healthcare Insurance Policy and Breast Cancer Surgery Trend in Korea
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3 Cases of Cancer Patients Whose Natural Killer Cell Activity Improved with Traditional Korean Medicine Treatment: A Case Series
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The prognostic value of the pretreatment serum albumin to globulin ratio for predicting adverse pathology in patients undergoing radical prostatectomy for prostate cancer
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Cost-Effectiveness Analysis of Active Surveillance Compared to Early Surgery in Small Papillary Thyroid Cancer: A Systemic Review
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Prediction of Cancer Incidence and Mortality in Korea, 2020: Kyu-Won Jung, Young-Joo Won, Seri Hong, Hyun-Joo Kong, Eun Sook Lee; Cancer Res Treat. 2020;52(2):351-358. Published online March 16, 2020; DOI: https://doi.org/10.4143/crt.2020.203

Abstract PDF PubReader ePub

Purpose
This study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. A Joinpoint regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend.
Results
In total, 243,263 new cancer cases and 80,546 cancer deaths are expected to occur in Korea in 2020. The most common cancer site is expected to be the lung, followed by the stomach, thyroid, colon/rectum, and breast. These five cancers types are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer among people who die is expected to be lung cancer, followed by liver, colon/rectal, pancreatic, and stomach cancers.
Conclusion
The incidence rates for all types of cancer in Korea are estimated to decrease gradually. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.

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Characteristics of second primary breast cancer after ovarian cancer: a Korea central cancer registry retrospective study
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Comparative performance of various human papillomavirus assays available in Korea for detecting cervical intraepithelial neoplasia
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Loss of adipose tissue or skeletal muscle during first‐line gemcitabine/nab‐paclitaxel therapy is associated with worse survival after second‐line therapy of advanced pancreatic cancer
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Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis
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Pilot study of the Korean national breast implant registry: Experiences and lessons learned
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Identifying and Validating of an Autophagy-Related Gene Signature for the Prediction of Early Relapse in Breast Cancer
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New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities
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