Cancer Research and Treatment

Original Articles

Selection Criteria for Active Surveillance of Patients with Prostate Cancer in Korea: A Multicenter Analysis of Pathology after Radical Prostatectomy: Chang Wook Jeong, Sung Kyu Hong, Seok Soo Byun, Seong Soo Jeon, Seong Il Seo, Hyun Moo Lee, Hanjong Ahn, Dong Deuk Kwon, Hong Koo Ha, Tae Gyun Kwon, Jae Seung Chung, Cheol Kwak, Hyung Jin Kim; Cancer Res Treat. 2018;50(1):265-274. Published online April 14, 2017; DOI: https://doi.org/10.4143/crt.2016.477

Abstract PDF Supplementary Material PubReader ePub

Purpose
Korean patients with prostate cancer (PC) typically present with a more aggressive disease than patients in Western populations. Consequently, it is unclear if the current criteria for active surveillance (AS) can safely be applied to Korean patients. Therefore, this study was conducted to define appropriate selection criteria for AS for patients with PC in Korea.
Materials and Methods
We conducted a multicenter retrospective study of 2,126 patients with low risk PC who actually underwent radical prostatectomy. The primary outcome was an unfavorable disease, which was defined by non-organ confined disease or an upgrading of the Gleason score to ≥ 7 (4+3). Predictive variables of an unfavorable outcome were identified by multivariate analysis using randomly selected training samples (n=1,623, 76.3%). We compared our selected criteria to various Western criteria for the primary outcome and validated our criteria using the remaining validation sample (n=503, 23.7%).
Results
A non-organ confined disease rate of 14.9% was identified, with an increase in Gleason score ≥ 7 (4+3) of 8.7% and a final unfavorable disease status of 20.8%. The following criteria were selected: Gleason score ≤ 6, clinical stage T1-T2a, prostate-specific antigen (PSA) ≤ 10 ng/mL, PSA density < 0.15 ng/mL/mL, number of positive cores ≤ 2, and maximum cancer involvement in any one core ≤ 20%. These criteria provided the lowest unfavorable disease rate (11.7%) when compared to Western criteria (13.3%-20.7%), and their validity was confirmed using the validation sample (5.9%).
Conclusion
We developed AS criteria which are appropriate for Korean patients with PC. Prospective studies using these criteria are now warranted.

Citations

Citations to this article as recorded by

Outcomes of active surveillance for Japanese patients with prostate cancer (PRIAS‐JAPAN)
Takuma Kato, Ryuji Matsumoto, Akira Yokomizo, Yoichiro Tohi, Hiroshi Fukuhara, Yoichi Fujii, Keiichiro Mori, Takuma Sato, Junichi Inokuchi, Katsuyoshi Hashine, Shinichi Sakamoto, Hidefumi Kinoshita, Koji Inoue, Toshiki Tanikawa, Takanobu Utsumi, Takayuki
BJU International.2024; 134(4): 652. CrossRef
Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry
Chris Bangma, Paul Doan, Lin Zhu, Sebastiaan Remmers, Daan Nieboer, Jozien Helleman, Monique J. Roobol, Mikio Sugimoto, Byung Ha Chung, Lui Shiong Lee, Mark Frydenberg, Laurence Klotz, Michael Peacock, Antoinette Perry, Anders Bjartell, Antti Rannikko, Mi
European Urology Oncology.2024;[Epub] CrossRef
Establishment of Prospective Registry of Active Surveillance for Prostate Cancer: The Korean Urological Oncology Society Database
Gyoohwan Jung, Jung Kwon Kim, Seong Soo Jeon, Jae Hoon Chung, Cheol Kwak, Chang Wook Jeong, Hanjong Ahn, Jae Young Joung, Tae Gyun Kwon, Sung Woo Park, Seok-Soo Byun
The World Journal of Men's Health.2023; 41(1): 110. CrossRef
The Role of Magnetic Resonance Imaging (MRI) and MRI-Targeted Biopsy for Active Surveillance
Chang Wook Jeong
Journal of Urologic Oncology.2023; 21(2): 97. CrossRef
Incidence and mortality projections for major cancers among Korean men until 2034, with a focus on prostate cancer
Sahyun Pak, Kyu-Won Jung, Eun-Hye Park, Young Hwii Ko, Young-Joo Won, Jae Young Joung
Investigative and Clinical Urology.2022; 63(2): 175. CrossRef
Role of single nucleotide polymorphisms of the HSD3B1 gene (rs6203 and rs33937873) in the prediction of prostate cancer risk
Yasmine Amrousy, Hesham Haffez, Doaa Abdou, Hanaa Atya
Molecular Medicine Reports.2022;[Epub] CrossRef
A single-center long-term experience of active surveillance for prostate cancer: 15 years of follow-up
Sang Hun Song, Jung Kwon Kim, Hakmin Lee, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun
Investigative and Clinical Urology.2021; 62(1): 32. CrossRef
The clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort
Jungyo Suh, Hyeong Dong Yuk, Minyong Kang, Bum Sik Tae, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak, Chang Wook Jeong
Investigative and Clinical Urology.2021; 62(4): 430. CrossRef
Comparison of Characteristics, Follow-up and Outcomes of Active Surveillance for Prostate Cancer According to Ethnicity in the GAP3 Global Consortium Database
Kerri Beckmann, Aida Santaolalla, Jozien Helleman, Peter Carroll, Byung Ha Chung, Lui Shiong Lee, Antoinette Perry, Jose Rubio-Briones, Mikio Sugimoto, Bruce Trock, Riccardo Valdagni, Prokar Dasgupta, Mieke Van Hemelrijck, Oussama Elhage, Bruce Trock, Beh
European Urology Open Science.2021; 34: 47. CrossRef
Patients with Biopsy Gleason Score 3 + 4 Are Not Appropriate Candidates for Active Surveillance
Juhyun Park, Sangjun Yoo, Min Chul Cho, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Hyeon Jeong
Urologia Internationalis.2020; 104(3-4): 199. CrossRef
Current status and progress of focal therapy in Asia
Takumi Shiraishi, Osamu Ukimura
Current Opinion in Urology.2018; 28(6): 529. CrossRef
The MMP2 rs243865 polymorphism increases the risk of prostate cancer: A meta-analysis
Kun Liu, Shuo Gu, Xuzhong Liu, Qing Sun, Yunyan Wang, Junsong Meng, Zongyuan Xu
Oncotarget.2017; 8(42): 72933. CrossRef

9,125 View
249 Download
9 Web of Science
12 Crossref

Oncologic and Functional Outcomes after Partial Nephrectomy Versus Radical Nephrectomy in T1b Renal Cell Carcinoma: A Multicenter, Matched Case-Control Study in Korean Patients: Hoon Ah Jang, Jin Wook Kim, Seok Soo Byun, Sung Hoo Hong, Young Jun Kim, Young Hyun Park, Kyung Suk Yang, Seok Cho, Jun Cheon, Seok Ho Kang; Cancer Res Treat. 2016;48(2):612-620. Published online June 5, 2015; DOI: https://doi.org/10.4143/crt.2014.122

Abstract PDF PubReader ePub

Purpose
The study was to compare the oncologic and functional outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for pathologically proven T1b renal cell carcinoma using pair-matched groups.
Materials and Methods
We reviewed our prospectively maintained database for RN and PN in T1b renal tumors surgically treated between 1999 and 2011 at five institutions in Korea. Of 611 patients treated with PN or RN for a solitary and NX/N0 M0 renal mass (4-7 cm), 577 (PN, 100; RN, 477) patients with pathologically confirmed pT1b remained for analysis. Study subjects were grouped by PN or RN, then matched by age, sex, comorbidities, body mass index, tumor size and depth, histologic type, and preoperative estimated glomerular filtration rate (eGFR) using propensities score. To evaluate oncologic outcomes, overall survival (OS), cancer- specific survival (CSS), and progression-free survival (PFS) rates were analyzed. The functional outcomes were evaluated by postoperative eGFR.
Results
The median follow-up in the RN group was 48.1 and 42.6 months in the PN group. The estimated 10-year CSS rate (PN 85.7% vs. RN 84.4%, p=0.52) and 5- and estimated 10-year PFS rates (PN: 86.4% and 79.2% vs. RN: 86.0% and 66.1%, p=0.66) did not differ significantly between groups. The estimated 10-year OS rate was significantly higher in the PN group (85.7%) compared to the RN group (73.3%) (p=0.003). PN was less likely to induce new-onset chronic kidney disease (CKD) and end-stage CKD compared with RN.
Conclusion
Our study suggests that patients treated with PN demonstrate a superior OS rate and postoperative renal function with analogous CSS and PFS rates compared with pair-matched patients treated with RN.

Citations

Citations to this article as recorded by

Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up
Ovidiu S. Barnoiu, Tom B. Johannesen, Lien M. Diep, Eskil S. Pedersen, Karin M. Hjelle, Christian Beisland
Scandinavian Journal of Urology.2024; 59: 1. CrossRef
Comparison of Oncological and Functional Outcomes of Radical Versus Partial Nephrectomy for cT1b Renal Cell Carcinoma: A Two-Centre, Matched Analysis
Luna van den Brink, Daniel L. van den Kroonenberg, Niels M. Graafland, Axel Bex, Harrie P. Beerlage, Jeroen R.A. van Moorselaar, Patricia J. Zondervan
Kidney Cancer.2024; 8(1): 51. CrossRef
Differences in the treatment patterns of small renal masses: A disaggregated analyses by race/ethnicity
Samuel Carbunaru, Jordan M. Rich, Yassamin Neshatvar, Katie Murray, Madhur Nayan
Urologic Oncology: Seminars and Original Investigations.2024; 42(12): 453.e1. CrossRef
Three-dimensional visualization techniques improve surgical Decision Making of robotic-assisted partial nephrectomy
Yuchao Wang, Qiliang Teng, Zhihong Dai, Chunyu Chen, Liren Zhang, Jiaxin Xie, Hao Wang, Zihan Xin, Sishan Chen, Yu Tai, Liang Wang, Bo Fan, Zhiyu Liu
Heliyon.2024; 10(21): e38806. CrossRef
Renal functional and cardiovascular outcomes of partial nephrectomy versus radical nephrectomy for renal tumors: a systematic review and meta-analysis
Mario Ochoa-Arvizo, Mariano García-Campa, Karla M. Santos-Santillana, Tobias Klatte, Luis R. García-Chairez, Alejandro D. González-Colmenero, Rigoberto Pallares-Méndez, Daniel E. Cervantes-Miranda, Hiram H. Plata-Huerta, Rene- Rodriguez-Gutierrez, Adrián
Urologic Oncology: Seminars and Original Investigations.2023; 41(3): 113. CrossRef
Frequency of Benign Lesions in Radiologically Presumed Renal Cell Carcinoma Taking Histopathology as Gold Standard
Ayesha Khan, Asad Shahzad Hassan, Naseem Akhtar, Rashid Ali, Rehan Mohsin, Altaf Hashmi, Nazish Mughal
Pakistan Journal of Health Sciences.2023; : 51. CrossRef
Laparoscopic partial versus radical nephrectomy for localized renal cell carcinoma over 4 cm
Zi-Jun Sun, Feng Liu, Hai-Bin Wei, Da-Hong Zhang
Journal of Cancer Research and Clinical Oncology.2023; 149(20): 17837. CrossRef
Long-term oncological results of surgical treatment of localized renal tumors
S. A. Rakul, K. V. Pozdnyakov, R. A. Eloev
Cancer Urology.2022; 17(4): 27. CrossRef
Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance
Katsunori Teranishi
International Journal of Molecular Sciences.2022; 23(13): 7228. CrossRef
Comparison of oncologic outcomes between elective partial and radical nephrectomy in patients with renal cell carcinoma in CT1B stadium
Predrag Maric, Predrag Aleksic, Branko Kosevic, Mirko Jovanovic, Vladimir Bancevic, Dejan Simic, Nemanja Rancic
Vojnosanitetski pregled.2022; 79(6): 591. CrossRef
Machine learning-based prediction model for late recurrence after surgery in patients with renal cell carcinoma
Hyung Min Kim, Seok-Soo Byun, Jung Kwon Kim, Chang Wook Jeong, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Yong-June Kim, Yun-Sok Ha, Sung-Hoo Hong
BMC Medical Informatics and Decision Making.2022;[Epub] CrossRef
Comparison of the oncological, perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma: A systematic review and meta-analysis of retrospective studies
Yucong Zhang, Gongwei Long, Haojie Shang, Beichen Ding, Guoliang Sun, Wei Ouyang, Man Liu, Yuan Chen, Heng Li, Hua Xu, Zhangqun Ye
Asian Journal of Urology.2021; 8(1): 117. CrossRef
Machine Learning Approach to Predict the Probability of Recurrence of Renal Cell Carcinoma After Surgery: Prediction Model Development Study
HyungMin Kim, Sun Jung Lee, So Jin Park, In Young Choi, Sung-Hoo Hong
JMIR Medical Informatics.2021; 9(3): e25635. CrossRef
Long-term results of surgical treatment for stage cT1 kidney cancer
Sergey A. Rakul, Pavel N. Romashchenko, Kirill V. Pozdnyakov, Nikolay A. Maistrenko
Bulletin of the Russian Military Medical Academy.2021; 23(3): 133. CrossRef
Retroperitoneal laparoscopic partial versus radical nephrectomy for large (≥ 4 cm) and anatomically complex renal tumors: A propensity score matching study
Wen Deng, Zhengtao Zhou, Jian Zhong, Junhua Li, Xiaoqiang Liu, Luyao Chen, Jingyu Zhu, Bin Fu, Gongxian Wang
European Journal of Surgical Oncology.2020; 46(7): 1360. CrossRef
Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report
Fan Yang, Zi-Chen Zhao, A-Jin Hu, Peng-Fei Sun, Bin Zhang, Ming-Chuan Yu, Juan Wang
World Journal of Clinical Cases.2020; 8(14): 3064. CrossRef
Peri‐operative and local control outcomes of robot‐assisted partial nephrectomy vs percutaneous cryoablation for renal masses: comparison after matching on radiological stage and renal score
Guillaume Fraisse, Loïc Colleter, Benoit Peyronnet, Zine‐Eddine Khene, Qusay Mandoorah, Yanish Soorojebally, Ali Bourgi, Alexandre De La Taille, Morgan Roupret, Eric De Kerviler, François Desgrandchamps, Karim Bensalah, Alexandra Masson‐Lecomte
BJU International.2019; 123(4): 632. CrossRef
Organ-sparing procedures in GU cancer: part 1—organ-sparing procedures in renal and adrenal tumors: a systematic review
Raouf Seyam, Mahmoud I. Khalil, Mohamed H. Kamel, Waleed M. Altaweel, Rodney Davis, Nabil K. Bissada
International Urology and Nephrology.2019; 51(3): 377. CrossRef
Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis
Yu-Li Jiang, Cheng-Xia Peng, Heng-Zi Wang, Lu-Jie Qian
BMC Urology.2019;[Epub] CrossRef
Partial nephrectomy versus radical nephrectomy for cT2 or greater renal tumors: a systematic review and meta-analysis
Jingdong Li, Yanping Zhang, Zhihai Teng, Zhenwei Han
Minerva Urologica e Nefrologica.2019;[Epub] CrossRef
Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery
Jitao Wu, Chalairat Suk‐Ouichai, Wen Dong, Elvis Caraballo Antonio, Ithaar H. Derweesh, Brian R. Lane, Sevag Demirjian, Jianbo Li, Steven C. Campbell
BJU International.2018; 121(1): 93. CrossRef
Oncologic Outcomes of Partial Nephrectomy for Stage T3a Renal Cell Cancer
Asaf Shvero, Ofer Nativ, Yasmin Abu-Ghanem, Dorit Zilberman, Bahouth Zaher, Max Levitt, Eddie Fridman, Orith Portnoy, Jacob Ramon, Zohar A. Dotan
Clinical Genitourinary Cancer.2018; 16(3): e613. CrossRef
External Validation of Contact Surface Area as a Predictor of Postoperative Renal Function in Patients Undergoing Partial Nephrectomy
Miki Haifler, Benjamin T. Ristau, Andrew M. Higgins, Marc C. Smaldone, Alexander Kutikov, Amnon Zisman, Robert G. Uzzo
Journal of Urology.2018; 199(3): 649. CrossRef
Survival outcomes in patients with large (≥7cm) clear cell renal cell carcinomas treated with nephron-sparing surgery versus radical nephrectomy: Results of a multicenter cohort with long-term follow-up
M. W. W. Janssen, J. Linxweiler, S. Terwey, S. Rugge, C.-H. Ohlmann, F. Becker, Ch. Thomas, A. Neisius, J. W. Thüroff, S. Siemer, M. Stöckle, F. C. Roos, Christian Schwentner
PLOS ONE.2018; 13(5): e0196427. CrossRef
Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study
Takaaki Hasegawa, Takashi Yamanaka, Hideo Gobara, Masaya Miyazaki, Haruyuki Takaki, Yozo Sato, Yoshitaka Inaba, Koichiro Yamakado
Japanese Journal of Radiology.2018; 36(9): 551. CrossRef
Néphrectomie partielle pour tumeur de plus de 7 cm : morbidité, résultats oncologiques et fonctionnels (UroCCR-7 study)
J. Rouffilange, A. Gobet, G. Capon, V. Comat, S. Lagabrielle, A. Guillaume, G. Robert, H. Bensadoun, J.-M. Ferrière, J.-C. Bernhard
Progrès en Urologie.2018; 28(12): 588. CrossRef
Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies
Maria Carmen Mir, Ithaar Derweesh, Francesco Porpiglia, Homayoun Zargar, Alexandre Mottrie, Riccardo Autorino
European Urology.2017; 71(4): 606. CrossRef
Utilization trends and outcomes up to 3 months of open, laparoscopic, and robotic partial nephrectomy
Jamie S. Pak, Jason J. Lee, Khawaja Bilal, Mark Finkelstein, Michael A. Palese
Journal of Robotic Surgery.2017; 11(2): 223. CrossRef
Early surgical outcomes and oncological results of robot‐assisted partial nephrectomy: a multicentre study
Rajan Veeratterapillay, Sanjai K. Addla, Clare Jelley, John Bailie, David Rix, Steve Bromage, Neil Oakley, Robin Weston, Naeem A. Soomro
BJU International.2017; 120(4): 550. CrossRef
External validation of the Arterial Based Complexity (ABC) scoring system in renal tumors treated by minimally invasive partial nephrectomy
Liangyou Gu, Xin Ma, Hongzhao Li, Yuanxin Yao, Yongpeng Xie, Luyao Chen, Yu Gao, Xu Zhang
Journal of Surgical Oncology.2017; 116(4): 507. CrossRef
Partial nephrectomy vs. radical nephrectomy for renal tumors: A meta-analysis of renal function and cardiovascular outcomes
Zheng Wang, Ganggang Wang, Qinghua Xia, Zhenhua Shang, Xiao Yu, Muwen Wang, Xunbo Jin
Urologic Oncology: Seminars and Original Investigations.2016; 34(12): 533.e11. CrossRef
Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases
Cheuk Fan Shum, Clinton D. Bahler, Philip S. Low, Timothy L. Ratliff, Steven V. Kheyfets, Jay P. Natarajan, George E. Sandusky, Chandru P. Sundaram
Journal of Endourology Case Reports.2016; 2(1): 189. CrossRef
Recommandations en onco-urologie 2016-2018 du CCAFU : Cancer du rein
K. Bensalah, L. Albiges, J.-C. Bernhard, P. Bigot, T. Bodin, R. Boissier, J.-M. Corréas, P. Gimel, J.-A. Long, F.-X. Nouhaud, I. Ouzaïd, P. Paparel, N. Rioux-Leclercq, A. Méjean
Progrès en Urologie.2016; 27: S27. CrossRef

13,646 View
187 Download
35 Web of Science
33 Crossref

First
Prev
Page of 1
Next
Last

Search