Jung Chul Kim, Junsik Park, Yong Jae Lee, Eun Ji Nam, Sang Wun Kim, Sung-Hoon Kim, Young Tae Kim, Se Ik Kim, Jae-Weon Kim, Byoung-Gie Kim, Jung-Yun Lee
Received December 23, 2024 Accepted March 16, 2025 Published online March 19, 2025
Purpose
Considering the current lack of consensus on post-poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) treatment strategies, this study aimed to evaluate the efficacy of subsequent therapy and compare the outcomes of regimes in patients with recurrent ovarian cancer after PARPi treatment.
Materials and Methods
This multi-center retrospective cohort study analyzed data on patients diagnosed with ovarian cancer between January 2012 and June 2023 who had previously used PARPi after first- to fourth-line platinum-based chemotherapy. The primary endpoint was progression-free survival (PFS), which was the interval between recurrence after using PARPi and subsequent recurrence in the case of recurrence.
Results
Of 318 patients, 147/318 (46.2%) recurred after the PARPi maintenance. Patients were categorized into groups based on subsequent therapy except non-treated (11/147, 7.5%): platinum-based chemotherapy (89/147, 60.5%), non-platinum-based chemotherapy (21/147, 14.3%), other treatments (26/147, 17.7%), and the median PFS (mPFS) for each group were 7.3, 4.8 and 11.4 months, respectively. Among the platinum-based chemotherapy group, the gemcitabine + carboplatin regimen demonstrated a longer mPFS (10.1 months) than the other regimens (6.6 months, p=0.0194). In non-platinum-based chemotherapy, no statistically significant differences were observed among the regimens. And, in the other therapy group, where the proportion of patients with oligometastasis was as high as 88.5%, no significant differences were observed among the therapies, including other modalities.
Conclusion
In the subsequent chemotherapy of recurrent ovarian cancer after platinum-based chemotherapy and PARPi, the gemcitabine + carboplatin regimen demonstrated a potential to delay recurrence more effectively compared to other therapies.
Purpose Nausea and vomiting are major non-hematological adverse events associated with niraparib maintenance therapy. This study aimed to investigate the time-trend patterns of niraparib-induced nausea and vomiting (NINV) and the associated risk factors in patients with ovarian cancer.
Materials and Methods In this prospective study, we enrolled patients with stage III-IV epithelial ovarian cancer who received niraparib as frontline maintenance therapy. The clinicopathological characteristics and time-trend patterns of patients with NINV were collected through in-person surveys and electronic medical records from the National Cancer Center.
Results Of 53 patients, 50 (94.3%) were diagnosed with high-grade serous ovarian carcinoma. BRCA mutations and homologous recombination deficiency (HRD) were identifi ed in 23 (43.4%) and 32 (60.4%) patients, respectively. Thirty-one patients (58.5%) had NINV. Time-trend analyses revealed that the fi rst peak intensity of NINV was reached at 3 h post-dose, and the second peak intensity was reached at 11 hour post-dose. NINV signifi cantly decreased from week 1 to weeks 8 and 12. In multivariate analyses of risk factors for NINV, HRD-positive tumors (p < 0.001) and prior experience of chemotherapy-induced nausea and vomiting (p=0.004) were associated with the occurrence of NINV.
Conclusion Pre-emptive treatment with antiemetics is required to manage early-phase NINV during niraparib maintenance therapy in patients with risk factors. Additional larger studies are needed to confi rm these fi ndings and to develop optimal preventive strategies for NINV.
Purpose This study aimed to investigate the impact of BRCA1/2 mutational status on survival outcomes in patients with platinum-sensitive relapsed (PSR) epithelial ovarian cancer (EOC).
Materials and Methods We retrospectively identified patients who received secondary treatment for PSR EOC at our institution between January 2007 and June 2021 and who underwent BRCA1/2 gene testing by either germline or somatic methods. The association between BRCA1/2 mutational status and survival outcomes was evaluated. Both secondary cytoreductive surgery (CRS) and maintenance therapy were stratified considering real-world clinical practice.
Results Of 262 patients, 91 (34.7%) and 171 (65.3%) were assigned to BRCA1/2 mutation and wild-type groups, respectively. The two groups had similar proportions of patients undergoing secondary CRS (26.4% vs. 32.7%, p=0.286) and maintenance therapy (54.9% vs. 46.2%, p=0.178). Overall, no differences in progression-free survival (PFS; median, 19.7 vs. 15.1 months, p=0.120) and overall survival (OS; p=0.400) were observed between the two groups. In multivariate analyses, BRCA1/2 mutational status was not associated with PFS (adjusted hazard ratio, 0.816; 95% confidence interval, 0.596 to 1.119; p=0.207). BRCA1/2 mutational status did not affect PFS among patients who underwent secondary CRS (n=80) and among those who did not (n=182) (p=0.074 and p=0.222, respectively). PFS did not differ in the BRCA1/2 mutational status among the patients who received bevacizumab maintenance (n=90, p=0.992).
Conclusion In this real-world evidence study, BRCA1/2 mutational status itself was not associated with PFS and OS in PSR EOC, which was consistent with whether secondary CRS or not and with bevacizumab maintenance.
Purpose This study aimed to identify patients who would benefit from third and subsequent lines of chemotherapy in recurrent epithelial ovarian cancer (EOC).
Materials and Methods Recurrent EOC patients who received third, fourth, or fifth-line palliative chemotherapy were retrospectively analyzed. Patients’ survival outcomes were assessed according to chemotherapy lines. Based on the best objective response, patients were divided into good-response (stable disease or better) and poor response (progressive disease or those who died before response assessment) groups. Survival outcomes were compared between the two groups, and factors associated with chemotherapy responses were investigated.
Results A total of 189 patients were evaluated. Ninety-four and 95 patients were identified as good and poor response group respectively, during the study period of 2008 to 2021. The poor response group showed significantly worse progression-free survival (median, 2.1 months vs. 9.7 months; p < 0.001) and overall survival (median, 5.0 months vs. 22.9 months; p < 0.001) compared with the good response group. In multivariate analysis adjusting for clinicopathologic factors, short treatment-free interval (TFI) (hazard ratio [HR], 5.557; 95% confidence interval [CI], 2.403 to 12.850), platinum-resistant EOC (HR, 2.367; 95% CI, 1.017 to 5.510), and non-serous/endometrioid histologic type (HR, 5.045; 95% CI, 1.152 to 22.088) were identified as independent risk factors for poor response. There was no difference in serious adverse events between good and poor response groups (p=0.167).
Conclusion Third and subsequent lines of chemotherapy could be carefully considered for palliative purposes in recurrent EOC patients with serous or endometrioid histology, initial platinum sensitivity, and long TFIs from the previous chemotherapy regimen.
Citations
Citations to this article as recorded by
CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression Chunyan Huang, Li Qin, Sailan Chen, Qin Huang Anti-Cancer Drugs.2022;[Epub] CrossRef
Purpose
This study aimed to present a single institutional experience with BRCA1/2 gene tests and the effects of pathogenic mutations in epithelial peritoneal, ovarian, and fallopian tube cancer (POFTC) on survival outcomes.
Materials and Methods
We identified patients with epithelial POFTCs who underwent BRCA1/2 gene testing by either germline or somatic methods between March 2007 and March 2020. Based on the BRCA1/2 test results, patients were divided into BRCA mutation and wild-type groups, followed by comparisons of clinicopathologic characteristics and survival outcomes after primary treatment.
Results
The annual number of POFTC patients who received BRCA1/2 gene tests increased gradually. In total, 511 patients were included and BRCA1/2 mutations were observed in 143 (28.0%). Among 57 patients who received both germline and somatic tests, three (5.3%) showed discordant results from the two tests. Overall, no differences in progression-free survival (PFS; p=0.467) and overall survival (p=0.641) were observed between the BRCA mutation and wild-type groups; however, multivariate analyses identified BRCA1/2 mutation as an independent favorable prognostic factor for PFS (adjusted hazard ratio [aHR], 0.765; 95% confidence interval [CI], 0.593 to 0.987; p=0.040). In 389 patients with International Federation of Gynecology and Obstetrics stage III-IV, different results were shown depending on primary treatment strategy: while BRCA1/2 mutation significantly improved PFS in the subgroup of neoadjuvant chemotherapy (aHR, 0.619; 95% CI, 0.385 to 0.995; p=0.048), it did not affect patient PFS in the subgroup of primary debulking surgery (aHR, 0.759; 95% CI, 0.530 to 1.089; p=0.135).
Conclusion BRCA1/2 mutations are frequently observed in patients with epithelial POFTCs, and such patients showed better PFS than did those harboring wild-type BRCA1/2.
Citations
Citations to this article as recorded by
Overview of Molecular Diagnostics in Irish Clinical Oncology Tyler Medina, Seán O. Hynes, Maeve Lowery, Paddy Gillespie, Walter Kolch, Cathal Seoighe HRB Open Research.2024; 7: 16. CrossRef
Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea Se Ik Kim, Hyeong In Ha, Kyung Jin Eoh, Jiwon Lim, Young-Joo Won, Myong Cheol Lim Frontiers in Oncology.2022;[Epub] CrossRef
Characteristics of homologous recombination repair pathway genes mutation in ovarian cancers Zongbi Yi, Min Chen, Shaoxing Sun, Chunxu Yang, Zijie Mei, Hui Yang, Qingming Xiang, Hui Qiu Cancer Innovation.2022; 1(3): 220. CrossRef
Se Ik Kim, Minsun Song, Suhyun Hwangbo, Sungyoung Lee, Untack Cho, Ju-Hyun Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Dae-Shik Suh, Taesung Park, Yong-Sang Song
Cancer Res Treat. 2019;51(3):1144-1155. Published online November 20, 2018
Purpose
Discovery of models predicting the exact prognosis of epithelial ovarian cancer (EOC) is necessary as the first step of implementation of individualized treatment. This study aimed to develop nomograms predicting treatment response and prognosis in EOC.
Materials and Methods
We comprehensively reviewed medical records of 866 patients diagnosed with and treated for EOC at two tertiary institutional hospitals between 2007 and 2016. Patients’ clinico-pathologic characteristics, details of primary treatment, intra-operative surgical findings, and survival outcomes were collected. To construct predictive nomograms for platinum sensitivity, 3-year progression-free survival (PFS), and 5-year overall survival (OS), we performed stepwise variable selection by measuring the area under the receiver operating characteristic curve (AUC) with leave-one-out cross-validation. For model validation, 10-fold cross-validation was applied.
Results
The median length of observation was 42.4 months (interquartile range, 25.7 to 69.9 months), during which 441 patients (50.9%) experienced disease recurrence. The median value of PFS was 32.6 months and 3-year PFS rate was 47.8% while 5-year OS rate was 68.4%. The AUCs of the newly developed nomograms predicting platinum sensitivity, 3-year PFS, and 5-year OS were 0.758, 0.841, and 0.805, respectively. We also developed predictive nomograms confined to the patients who underwent primary debulking surgery. The AUCs for platinum sensitivity, 3-year PFS, and 5-year OS were 0.713, 0.839, and 0.803, respectively.
Conclusion
We successfully developed nomograms predicting treatment response and prognosis of patients with EOC. These nomograms are expected to be useful in clinical practice and designing clinical trials.
Citations
Citations to this article as recorded by
Comprehensive analyses of mitophagy-related genes and mitophagy-related lncRNAs for patients with ovarian cancer Jianfeng Zheng, Shan Jiang, Xuefen Lin, Huihui Wang, Li Liu, Xintong Cai, Yang Sun BMC Women's Health.2024;[Epub] CrossRef
Peripheral and tumor‐infiltrating immune cells are correlated with patient outcomes in ovarian cancer Weiwei Zhang, Yawen Ling, Zhidong Li, Xingchen Peng, Yazhou Ren Cancer Medicine.2023; 12(8): 10045. CrossRef
Nonalcoholic fatty liver disease and early prediction of gestational diabetes mellitus using machine learning methods Seung Mi Lee, Suhyun Hwangbo, Errol R. Norwitz, Ja Nam Koo, Ig Hwan Oh, Eun Saem Choi, Young Mi Jung, Sun Min Kim, Byoung Jae Kim, Sang Youn Kim, Gyoung Min Kim, Won Kim, Sae Kyung Joo, Sue Shin, Chan-Wook Park, Taesung Park, Joong Shin Park Clinical and Molecular Hepatology.2022; 28(1): 105. CrossRef
Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer Part 2: Medical Perspectives Stanislas Quesada, Michel Fabbro, Jérôme Solassol Cancers.2022; 14(4): 1098. CrossRef
Construction and validation of a transcription factors-based prognostic signature for ovarian cancer Qingyuan Cheng, Liman Li, Mingxia Yu Journal of Ovarian Research.2022;[Epub] CrossRef
Predicting preterm birth through vaginal microbiota, cervical length, and WBC using a machine learning model Sunwha Park, Jeongsup Moon, Nayeon Kang, Young-Han Kim, Young-Ah You, Eunjin Kwon, AbuZar Ansari, Young Min Hur, Taesung Park, Young Ju Kim Frontiers in Microbiology.2022;[Epub] CrossRef
Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma Jiayi Li, Dongyan Cao Frontiers in Oncology.2022;[Epub] CrossRef
Recent Advances and Future Directions of Diagnostic and Prognostic Prediction Models in Ovarian Cancer Judan Zeng, Wenjiao Cao, Lihua Wang Journal of Shanghai Jiaotong University (Science).2021; 26(1): 10. CrossRef
Sphingolipids as multifaceted mediators in ovarian cancer MelissaR Pitman, Martin K. Oehler, Stuart M. Pitson Cellular Signalling.2021; 81: 109949. CrossRef
Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition Jiani Yang, Jun Ma, Yue Jin, Shanshan Cheng, Shan Huang, Nan Zhang, Yu Wang Scientific Reports.2021;[Epub] CrossRef
Prediction Models for the Clinical Severity of Patients With COVID-19 in Korea: Retrospective Multicenter Cohort Study Bumjo Oh, Suhyun Hwangbo, Taeyeong Jung, Kyungha Min, Chanhee Lee, Catherine Apio, Hyejin Lee, Seungyeoun Lee, Min Kyong Moon, Shin-Woo Kim, Taesung Park Journal of Medical Internet Research.2021; 23(4): e25852. CrossRef
Development of Machine Learning Models to Predict Platinum Sensitivity of High-Grade Serous Ovarian Carcinoma Suhyun Hwangbo, Se Ik Kim, Ju-Hyun Kim, Kyung Jin Eoh, Chanhee Lee, Young Tae Kim, Dae-Shik Suh, Taesung Park, Yong Sang Song Cancers.2021; 13(8): 1875. CrossRef
M2 Macrophage-Based Prognostic Nomogram for Gastric Cancer After Surgical Resection Jianwen Hu, Yongchen Ma, Ju Ma, Yanpeng Yang, Yingze Ning, Jing Zhu, Pengyuan Wang, Guowei Chen, Yucun Liu Frontiers in Oncology.2021;[Epub] CrossRef
Prognosis for intrahepatic cholangiocarcinoma patients treated with postoperative adjuvant transcatheter hepatic artery chemoembolization Ji-Bin Liu, Kai-Jian Chu, Chang-Chun Ling, Ting-Miao Wu, Hui-Min Wang, Yi Shi, Zhi-Zhen Li, Jing-Han Wang, Zhi-Jun Wu, Xiao-Qing Jiang, Gao-Ren Wang, Yu-Shui Ma, Da Fu Current Problems in Cancer.2020; 44(6): 100612. CrossRef
Can we predict who lives long with ovarian cancer? Michael A. Bookman Cancer.2019; 125(S24): 4578. CrossRef
Purpose
The purpose of this study is to compare quality of life (QoL) and sexual functioning between sexually active cervical cancer survivors and healthy women.
Materials and Methods
In this cross-sectional study, propensity-score-matched cervical cancer survivors (n=104) and healthy women (n=104) were compared. All women had engaged in sexual activity within the previous 3 months, and cervical cancer survivors showed no evidence of disease after primary treatment. QoL and sexual functioning were assessed using three questionnaires; the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), Cervical Cancer Module (EORTC QLQ-CX24), and the Female Sexual Function Index (FSFI).
Results
Significantly higher scores for lymphedema were observed in the cervical cancer survivors group compared with the healthy women group (mean, 20.2 vs. 12.2; p < 0.05). Sexuality, both in terms of sexual activity, sexual enjoyment, and sexual worry (EORTC QLQ-CX24), and in terms of desire, arousal, lubrication, orgasm, satisfaction, and pain (FSFI) were similar between the groups. When the scale of sexual/vaginal functioning in EORTC QLQ-CX24 was divided into individual questions, cervical cancer survivors reported shorter vaginal length than the control group, but without statistical significance (mean, 80.6 vs. 85.4; p=0.077).
Conclusion
Compared with healthy women, sexuality was not impaired in cervical cancer survivors who showed no evidence of disease after primary treatment and engaging in sexual activity. Further prospective cohort studies are warranted to confirm this finding.
Citations
Citations to this article as recorded by
Longitudinal study on quality of life following cervical cancer treatment in Botswana Surbhi Grover, Rohini K Bhatia, Salman Khan, Paseka Tladi, Lesego Gabaitiri, Memory Bvochora-Nsingo, Sebathu Chiyapo, Dawn Balang, Shalini Vinod, Mark N Polizzotto, Natalie Taylor, Karen Canfell, Nicola Zetola, Doreen Ramogola-Masire, Lilie L Lin, Erle Ro BMJ Global Health.2025; 10(3): e017206. CrossRef
The feasibility and acceptability of delivering and evaluating a physical activity intervention (ACCEPTANCE) for cervical cancer survivors Nessa Millet, Hilary J. McDermott, Fehmidah Munir, Charlotte L. Edwardson, Tatiana Plekhanova, Esther L. Moss Pilot and Feasibility Studies.2025;[Epub] CrossRef
Sexual quality of life between healthy women and women with gynecological cancer: Results of a hospital‐based case–control study in Türkiye Ekin Dila Topaloğlu Ören, Selin Kiziltaş Journal of Obstetrics and Gynaecology Research.2024; 50(3): 456. CrossRef
Quality of life in long-term cervical cancer survivors compared with healthy women and women with benign gynecological disorders Jorge Cea García, Inmaculada Rodríguez Jiménez, Francisco Márquez Maraver, Laura Ríos-Pena, M. Carmen Rubio Rodríguez European Journal of Obstetrics & Gynecology and Reproductive Biology.2024; 297: 78. CrossRef
Pre- and Post-Treatment Quality of Life Among Patients with Advanced Stage Cervical Cancer at Tikur Anbessa Specialized Hospital, Ethiopia Roza Teshome, Irene Yang, Edom Woldetsadik, Eshetu Girma, Melinda Higgins, Jessica Wells Cancer Management and Research.2024; Volume 16: 311. CrossRef
Female sexual function in long-term cervical cancer survivors compared with healthy women and women affected by benign gynecological disorders Jorge Cea García, Francisco Márquez Maraver, Inmaculada Rodríguez Jiménez, Laura Ríos-Pena, M. Carmen Rubio Rodríguez European Journal of Obstetrics & Gynecology and Reproductive Biology.2024; 299: 43. CrossRef
Prevalence of sexual dysfunction in women with cervical cancer: a systematic review and meta-analysis Maolin Qian, Lan Wang, Jiajun Xing, Xiao Shan, Juan Wu, Xiaoqin Liu Psychology, Health & Medicine.2023; 28(2): 494. CrossRef
Trends and future projections of cervical cancer‐related outcomes in Japan: What happens if the HPV vaccine program is not implemented? Atsuko Sakakibara, Takeo Nakayama, Hiroyuki Uchida, Youichi Odagiri, Yuri Ito, Toshiro Katayama, Yutaka Ueda, Toshihiro Higuchi, Koichi Terakawa, Kunihiko Matsui, Kikuko Miyazaki, Ikuo Konishi International Journal of Cancer.2023; 152(9): 1863. CrossRef
Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review Stefano Cianci, Mattia Tarascio, Martina Arcieri, Marco La Verde, Canio Martinelli, Vito Andrea Capozzi, Vittorio Palmara, Ferdinando Gulino, Salvatore Gueli Alletti, Giuseppe Caruso, Stefano Restaino, Giuseppe Vizzielli, Carmine Conte, Marco Palumbo, Alf Medicina.2023; 59(4): 704. CrossRef
Association between cervical cancer-related anxiety and depression symptoms and health-related quality of life: A Moroccan cross-sectional study Asmaa Azizi, Doha Achak, Amal Boutib, Samia Chergaoui, Elmadani Saad, Abderraouf Hilali, Amr S. Soliman, Ibtissam Youlyouz-Marfak, Abdelghafour Marfak Clinical Epidemiology and Global Health.2023; 22: 101328. CrossRef
Impacto del cáncer de cuello uterino en la sexualidad femenina Camilla R. Albæk-Jakobsen, Pere Fusté-Brull Medicina.2023; 24(2): 21. CrossRef
Sexual Behaviors and Intimate Relationships of Sexual Partners of Young Patients with Early-Stage Cervical Cancer: A Qualitative Study Mingyue Li, Dongyang Wang, Jiaxiang Huang, Shunlian Luan, Qinghua Wang International Journal of General Medicine.2023; Volume 16: 5377. CrossRef
Long-term Quality of Life and Sexual Function After Neoadjuvant Chemotherapy and Radical Surgery for Locally Advanced Cervical Cancer Innocenza Palaia, Giusi Santangelo, Giuseppe Caruso, Giorgia Perniola, Valentina Tibaldi, Ludovico Muzii, Pierluigi Benedetti Panici, Violante Di Donato The Journal of Sexual Medicine.2022; 19(4): 613. CrossRef
The Importance of Social Support, Optimism and Resilience on the Quality of Life of Cancer Patients Iván Ruiz-Rodríguez, Isabel Hombrados-Mendieta, Anabel Melguizo-Garín, María José Martos-Méndez Frontiers in Psychology.2022;[Epub] CrossRef
Relationship of sexual quality of life and mental well-being in undergraduate women in a Canadian university Niki Oveisi, Zeba Khan, Lori A. Brotto The Canadian Journal of Human Sexuality.2022; 31(3): 422. CrossRef
Longitudinal Health-Related Quality of Life Study among Cervical Cancer Patients Treated with Radiotherapy Małgorzata Pasek, Lilia Suchocka, Grażyna Osuch-Pęcak, Konrad Muzykiewicz, Ewa Iwańska, Helena Kaducakowa, Anna Goździalska, Magdalena Goździalska Journal of Clinical Medicine.2021; 10(2): 226. CrossRef
Sexual Function and the Role of Sexual Communication in Women Diagnosed with Cervical Cancer: A Systematic Review Magdalena Liberacka-Dwojak, Paweł Izdebski International Journal of Sexual Health.2021; 33(3): 385. CrossRef
Contribution of Sociodemographic, Clinical, and Psychological Variables to Quality of Life in Women with Cervical Cancer in the Follow-Up Phase Ana Clara Lopes, Rosário Bacalhau, Martim Santos, Marta Pereira, M. Graça Pereira Journal of Clinical Psychology in Medical Settings.2020; 27(3): 603. CrossRef
Health-related quality of life and associated factors among cervical cancer patients at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia Liya Teklu Araya, Teferi Gedif Fenta, Beate Sander, Girma Tekle Gebremariam, Gebremedhin Beedemariam Gebretekle Health and Quality of Life Outcomes.2020;[Epub] CrossRef
Le retentissement du cancer utérin et ses traitements sur la sexualité A. Ghorbel, A. Yousfi, R. Abidi, S. Yahyaoui, S. Zaraa, K. Mahjoubi, A. Belaid, W. Gargouri, C. Nasr Sexologies.2020; 29(4): 186. CrossRef
Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early‐stage cervical cancer Hideaki Yahata, Kenzo Sonoda, Kaoru Okugawa, Hiroshi Yagi, Tatsuhiro Ohgami, Masafumi Yasunaga, Ichiro Onoyama, Eisuke Kaneki, Kazuo Asanoma, Kiyoko Kato Journal of Obstetrics and Gynaecology Research.2019; 45(11): 2255. CrossRef
Qualidade de vida e fatores associados em mulheres sobreviventes ao câncer do colo do útero Camila Soares Lima Corrêa, Isabel Cristina Gonçalves Leite, Anna Paula Silva Andrade, Simone Meira Carvalho, Ricardo Miranda Borges, Maximiliano Ribeiro Guerra HU Revista.2019; 43(4): 307. CrossRef
The EOLO (End-of-Life Ovarian Cancer) Study: Approach to Ovarian Cancer Patients at the End of Life Innocenza Palaia, Federica Tomao, Giusi Santangelo, Anna Di Pinto, Carolina Maria Sassu, Giorgia Perniola, Angela Musella, Violante Di Donato, Antonella Giancotti, Pierluigi Benedetti Panici Oncology.2019; 97(5): 306. CrossRef
Vaginal development and sexual functioning in young women after stem cell transplantation, chemotherapy, and/or radiotherapy for childhood hematological diseases Fausta Beneventi, Elena Locatelli, Margherita Simonetta, Chiara Cavagnoli, Raffaella Pampuri, Camilla Bellingeri, Irene De Maggio, Beatrice Ruspini, Santina Recupero, Giovanna Giorgiani, Arsenio Spinillo Bone Marrow Transplantation.2018; 53(9): 1157. CrossRef
Cross-cultural adaptation and validation of the Functional Assessment of Chronic Illness Therapy – Cervical Dysplasia (FACIT-CD) questionnaire for Serbian women Vesna Kesić, Radmila Sparić, Rafal Watrowski, Jelena Dotlić, Radomir Stefanović, Gorica Marić, Tatjana Pekmezović European Journal of Obstetrics & Gynecology and Reproductive Biology.2018; 226: 7. CrossRef
Percutaneous parametrial dose escalation in women with advanced cervical cancer: feasibility and efficacy in relation to long-term quality of life Sati Akbaba, Jan Tobias Oelmann-Avendano, Tilman Bostel, Harald Rief, Nils Henrik Nicolay, Juergen Debus, Katja Lindel, Robert Foerster Radiology and Oncology.2018; 52(3): 320. CrossRef
Attitudes Regarding HPV Vaccinations of Children among Mothers with Adolescent Daughters in Korea Kyong-No Lee, Kylie Hae-Jin Chang, Seong-Sik Cho, Sung-Ho Park, Sung Taek Park Journal of Korean Medical Science.2017; 32(1): 130. CrossRef
Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study Nicoletta De Rosa, Giada Lavitola, Pierluigi Giampaolino, Ilaria Morra, Carmine Nappi, Giuseppe Bifulco BioMed Research International.2017; 2017: 1. CrossRef
Körperliche Beschwerden und psychosoziale Folgen nach einer Zervixkarzinomerkrankung Kristina Geue, Elisabeth Sowa, Susanne Kuhnt Der Onkologe.2016; 22(10): 780. CrossRef