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2 "Samina Park"
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Lung and Thoracic cancer
The Role of Adjuvant Therapy Following Surgical Resection of Small Cell Lung Cancer: A Multi-Center Study
Seong Yong Park, Samina Park, Geun Dong Lee, Hong Kwan Kim, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Tae Hee Hong, Yong Soo Choi, Jhingook Kim, Jong Ho Cho, Young Mog Shim, Jae Ill Zo, Kwon Joong Na, In Kyu Park, Chang Hyun Kang, Young-Tae Kim, Byung Jo Park, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik
Cancer Res Treat. 2023;55(1):94-102.   Published online June 9, 2022
DOI: https://doi.org/10.4143/crt.2022.290
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This multi-center, retrospective study was conducted to evaluate the long-term survival in patients who underwent surgical resection for small cell lung cancer (SCLC) and to identify the benefit of adjuvant therapy following surgery.
Materials and Methods
The data of 213 patients who underwent surgical resection for SCLC at four institutions were retrospectively reviewed. Patients who received neoadjuvant therapy or an incomplete resection were excluded.
Results
The mean patient age was 65.29±8.93 years, and 184 patients (86.4%) were male. Lobectomies and pneumonectomies were performed in 173 patients (81.2%), and 198 (93%) underwent systematic mediastinal lymph node dissections. Overall, 170 patients (79.8%) underwent adjuvant chemotherapy, 42 (19.7%) underwent radiotherapy to the mediastinum, and 23 (10.8%) underwent prophylactic cranial irradiation. The median follow-up period was 31.08 months (interquartile range, 13.79 to 64.52 months). The 5-year overall survival (OS) and disease-free survival were 53.4% and 46.9%, respectively. The 5-year OS significantly improved after adjuvant chemotherapy in all patients (57.4% vs. 40.3%, p=0.007), and the survival benefit of adjuvant chemotherapy was significant in patients with negative node pathology (70.8% vs. 39.7%, p=0.004). Adjuvant radiotherapy did not affect the 5-year OS (54.6% vs. 48.5%, p=0.458). Age (hazard ratio [HR], 1.032; p=0.017), node metastasis (HR, 2.190; p < 0.001), and adjuvant chemotherapy (HR, 0.558; p=0.019) were associated with OS.
Conclusion
Adjuvant chemotherapy after surgical resection in patients with SCLC improved the OS, though adjuvant radiotherapy to the mediastinum did not improve the survival or decrease the locoregional recurrence rate.

Citations

Citations to this article as recorded by  
  • Application of postoperative adjuvant radiotherapy in limited-stage small cell lung cancer: A systematic review and meta-analysis
    Chuanhao Zhang, Genghao Zhao, Huajian Wu, Jianing Jiang, Wenyue Duan, Zhijun Fan, Zhe Wang, Ruoyu Wang
    Radiotherapy and Oncology.2024; 193: 110123.     CrossRef
  • A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection
    Sevcan Atay
    Cancers.2023; 15(21): 5219.     CrossRef
  • 5,802 View
  • 142 Download
  • 2 Web of Science
  • 2 Crossref
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Current Trends of Lung Cancer Surgery and Demographic and Social Factors Related to Changes in the Trends of Lung Cancer Surgery: An Analysis of the National Database from 2010 to 2014
Samina Park, In Kyu Park, Eung Re Kim, Yoohwa Hwang, Hyun Joo Lee, Chang Hyun Kang, Young Tae Kim
Cancer Res Treat. 2017;49(2):330-337.   Published online July 18, 2016
DOI: https://doi.org/10.4143/crt.2016.196
AbstractAbstract PDFPubReaderePub
Purpose
We investigated current trends in lung cancer surgery and identified demographic and social factors related to changes in these trends.
Materials and Methods
We estimated the incidence of lung cancer surgery using a procedure code-based approach provided by the Health Insurance Review and Assessment Service (http://opendata.hira.or.kr). The population data were obtained every year from 2010 to 2014 from the Korean Statistical Information Service (http://kosis.kr/). The annual percent change (APC) and statistical significance were calculated using the Joinpoint software.
Results
From January 2010 to December 2014, 25,687 patients underwent 25,921 lung cancer surgeries, which increased by 45.1% from 2010 to 2014. The crude incidence rate of lung cancer surgery in each year increased significantly (APC, 9.5; p < 0.05). The male-to-female ratio decreased from 2.1 to 1.6 (APC, −6.3; p < 0.05). The incidence increased in the age group of ≥ 70 years for both sexes (male: APC, 3.7; p < 0.05; female: APC, 5.96; p < 0.05). Furthermore, the proportion of female patients aged ≥ 65 years increased (APC, 7.2; p < 0.05), while that of male patients aged < 65 years decreased (APC, −3.9; p < 0.05). The proportions of segmentectomies (APC, 17.8; p < 0.05) and lobectomies (APC, 7.5; p < 0.05) increased, while the proportion of pneumonectomies decreased (APC, −6.3; p < 0.05). Finally, the proportion of patients undergoing surgery in Seoul increased (APC, 1.1; p < 0.05), while the proportion in other areas decreased (APC, −1.5; p < 0.05).
Conclusion
An increase in the use of lung cancer surgery in elderly patients and female patients, and a decrease in the proportion of patients requiring extensive pulmonary resection were identified. Furthermore, centralization of lung cancer surgery was noted.

Citations

Citations to this article as recorded by  
  • Clinical characteristics and course of pulmonary artery stump thrombosis following lung cancer surgery: A retrospective study from tertiary care hospital
    Ji-Eun Park, Seung-Ick Cha, Deok Heon Lee, Eung Bae Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Seung-Soo Yoo, Shin-Yup Lee, Jaehee Lee, Chang-Ho Kim, Jae-Yong Park
    Medicine.2024; 103(2): e36879.     CrossRef
  • Lung cancer screening, diagnosis, and treatment: The radiologist's perspective
    Bingqing Long, Zeng Xiong, Manzo Habou
    Meta-Radiology.2024; 2(1): 100066.     CrossRef
  • Inter-prefectural and urban–rural regional disparities in lung cancer surgery: a Japanese nationwide population-based cohort study from 2017 to 2019
    Masamitsu Kido, Satoru Okada, Naoyuki Takashima, Luying Yan, Atsuki Uchibori, Koji Sensaki, Tetsuo Kido, Masayoshi Inoue
    Surgery Today.2024; 54(12): 1428.     CrossRef
  • Peri- and postoperative morbidity and mortality in older patients with non-small cell lung cancer: a matched-pair study
    Seyer Safi, Maximilian Robert Gysan, Dorothea Weber, Rouven Behnisch, Thomas Muley, Michael Allgäuer, Hauke Winter, Hans Hoffmann, Martin Eichhorn
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study
    So Yeon Kim, Gerard A. Silvestri, Yeon Wook Kim, Roger Y. Kim, Sang-Won Um, Yunjoo Im, Jung Hye Hwang, Seung Ho Choi, Jung Seop Eom, Kang Mo Gu, Yong-Soo Kwon, Shin Yup Lee, Hyun Woo Lee, Dong Won Park, Yeonjeong Heo, Seung Hun Jang, Kwang Yong Choi, Yeol
    Journal of Thoracic Oncology.2024;[Epub]     CrossRef
  • Advanced surgical technologies for lung cancer treatment: Current status and perspectives
    Hongfei Cai, Yonghui Wang, Da Qin, Youbin Cui, Hongbo Zhang
    Engineered Regeneration.2023; 4(1): 55.     CrossRef
  • Domestic medical travel from non-Seoul regions to Seoul for initial breast cancer treatment: a nationwide cohort study
    Jae Ho Jeong, Jinhong Jung, Hee Jeong Kim, Jong Won Lee, Beom-Seok Ko, Byung Ho Son, Kyung Hae Jung, Il Yong Chung
    Annals of Surgical Treatment and Research.2023; 104(2): 71.     CrossRef
  • Crataegus pinnatifida Bunge root extract induces apoptosis of murine lung carcinoma cells in vitro
    Minjeong Kwon, Jongbeom Chae, Ju-Ock Nam
    Journal of Applied Biological Chemistry.2023;[Epub]     CrossRef
  • Disparities in lung cancer short- and long-term outcomes after surgery: Analysis from the national cancer database
    Mark R. Korst, Aman M. Patel, Daniel J. Garcia, Akash R. Patel, Hassaam S. Choudhry, Joseph G. Santitoro, Vincent Yeung, Joshua A. Kra
    Cancer Treatment and Research Communications.2023; 37: 100777.     CrossRef
  • Trend of lung cancer surgery, hospital selection, and survival between 2005 and 2016 in South Korea
    Dohun Kim, Gil‐Won Kang, Hoyeon Jang, Jun Yeun Cho, Bumhee Yang, Hee Chul Yang, Jinwook Hwang
    Thoracic Cancer.2022; 13(2): 210.     CrossRef
  • Current Status of Lung Cancer and Surgery Based on Studies Using a Nationwide Database
    Dohun Kim, Jung-Won Lee
    Journal of Chest Surgery.2022; 55(1): 1.     CrossRef
  • Assessment of textbook outcome after lobectomy for early‐stage non‐small cell lung cancer in a Korean institution: A retrospective study
    Woo Sik Yu, Jaeyong Shin, Jung A Son, Joonho Jung, Seokjin Haam
    Thoracic Cancer.2022; 13(8): 1211.     CrossRef
  • Pulmonary vein stump thrombosis after lung resection for lung cancer: clinical features and outcome
    Ji-Eun Park, Seung-Ick Cha, Deok Heon Lee, Eung Bae Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Seung-Soo Yoo, Shin-Yup Lee, Jaehee Lee, Chang-Ho Kim, Jae-Yong Park
    Blood Coagulation & Fibrinolysis.2022; 33(6): 295.     CrossRef
  • Healthcare vulnerability disparities in pancreatic cancer treatment and mortality using the Korean National Sample Cohort: a retrospective cohort study
    Sung Hoon Jeong, Hyeon Ji Lee, Choa Yun, Il Yun, Yun Hwa Jung, Soo Young Kim, Hee Seung Lee, Sung-In Jang
    BMC Cancer.2022;[Epub]     CrossRef
  • Trends in the traditional cardiothoracic surgery resident operative experience for cardiac cases: An analysis of Accreditation Council for Graduate Medical Education case logs
    Aakash M. Shah, Emaad Siddiqui, Sari D. Holmes, Alexis Okoh, Mohamed Abdullah, Kristopher Deatrick, Sunjay Kaushal, Justin Sambol
    The Journal of Thoracic and Cardiovascular Surgery.2021; 161(3): 1064.     CrossRef
  • Does Delaying Time in Cancer Treatment Affect Mortality? A Retrospective Cohort Study of Korean Lung and Gastric Cancer Patients
    Kyu-Tae Han, Woorim Kim, Seungju Kim
    International Journal of Environmental Research and Public Health.2021; 18(7): 3462.     CrossRef
  • Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?
    Elizabeth Ahern, Ben J Solomon, Rina Hui, Nick Pavlakis, Ken O'Byrne, Brett G M Hughes
    Journal for ImmunoTherapy of Cancer.2021; 9(6): e002248.     CrossRef
  • Do Patients Residing in Provincial Areas Transport and Spend More on Cancer Treatment in Korea?
    Woorim Kim, Kyu-Tae Han, Seungju Kim
    International Journal of Environmental Research and Public Health.2021; 18(17): 9247.     CrossRef
  • Pulmonary Metastasectomy in Colorectal Cancer: A Population-Based Retrospective Cohort Study Using the Korean National Health Insurance Database
    Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
    Cancer Research and Treatment.2021; 53(4): 1104.     CrossRef
  • Rare location and drainage pattern of right pulmonary veins and aberrant right upper lobe bronchial branch: A case report
    Fu-Qiang Wang, Rui Zhang, Han-Lu Zhang, Yun-Hai Mo, Yu Zheng, Guang-Hao Qiu, Yun Wang
    World Journal of Clinical Cases.2021; 9(32): 9954.     CrossRef
  • Comment on: ‘Hospital lung surgery volume and patient outcomes’
    Rob Stirling, Michael Stenger, John Zalcberg
    Lung Cancer.2020; 142: 138.     CrossRef
  • Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis
    Sanghyun Ahn, Jin-Young Min, Hyunyoung G. Kim, Hyejin Mo, Seung-Kee Min, Sangil Min, Jongwon Ha, Kyoung-Bok Min
    BMC Surgery.2020;[Epub]     CrossRef
  • Time trends and predictors of survival in surgically resected early‐stage non–small cell lung cancer patients
    Jitesh B. Shewale, Erin M. Corsini, Arlene M. Correa, Eric L. Brown, Luis G. Leon‐Novelo, Alan G. Nyitray, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack Roth, Garrett L. Walsh, Ara A. Vaporciyan, Stephen G. Swisher, Boris Sepe
    Journal of Surgical Oncology.2020; 122(3): 495.     CrossRef
  • Patterns of percutaneous transthoracic needle biopsy (PTNB) of the lung and risk of PTNB-related severe pneumothorax: A nationwide population-based study
    Bo Ram Yang, Mi-Sook Kim, Chang Min Park, Soon Ho Yoon, Kum Ju Chae, Joongyub Lee, James West
    PLOS ONE.2020; 15(7): e0235599.     CrossRef
  • Surgical Treatment of Lung Cancer
    Haley Hoy, Thuy Lynch, Monica Beck
    Critical Care Nursing Clinics of North America.2019; 31(3): 303.     CrossRef
  • Higher Age Puts Lung Cancer Patients at Risk for Not Receiving Anti-cancer Treatment
    Won-Il Choi, Jiah Choi, Mi-Ae Kim, Gyumin Lee, Jihyeon Jeong, Choong Won Lee
    Cancer Research and Treatment.2019; 51(3): 1241.     CrossRef
  • Recent Trends in Demographics, Surgery, and Prognosis of Patients with Surgically Resected Lung Cancer in a Single Institution from Korea
    Jae Kwang Yun, Han Pil Lee, Geun Dong Lee, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Sehoon Choi
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Pharmacodynamics of Pre-Operative PD1 checkpoint blockade and receptor activator of NFkB ligand (RANKL) inhibition in non-small cell lung cancer (NSCLC): study protocol for a multicentre, open-label, phase 1B/2, translational trial (POPCORN)
    Elizabeth Ahern, Annette Cubitt, Emma Ballard, Michele W. L. Teng, William C. Dougall, Mark J. Smyth, David Godbolt, Rishendran Naidoo, Amanda Goldrick, Brett G. M. Hughes
    Trials.2019;[Epub]     CrossRef
  • Progress in the Management of Early-Stage Non–Small Cell Lung Cancer in 2017
    Jessica S. Donington, Young Tae Kim, Betty Tong, Andre L. Moreira, Jamie Bessich, Kathleen D. Weiss, Yolonda L. Colson, Dennis Wigle, Raymond U. Osarogiagbon, Jeffrey Zweig, Heather Wakelee, Justin Blasberg, Megan Daly, Leah Backhus, Paul Van Schil
    Journal of Thoracic Oncology.2018; 13(6): 767.     CrossRef
  • 10,742 View
  • 290 Download
  • 16 Web of Science
  • 29 Crossref
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