Cancer Research and Treatment

Case Reports

PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers: Hye Sung Won, Eun Deok Chang, Sae Jung Na, In Yong Whang, Dong Soo Lee, Sun Hyong You, Yong Seok Kim, Jeong Soo Kim; Cancer Res Treat. 2019;51(1):402-407. Published online February 27, 2018; DOI: https://doi.org/10.4143/crt.2017.579

PTEN hamartoma tumor syndrome is a spectrum of disorders characterized by unique phenotypic features including multiple hamartomas caused by mutations of the tumor suppressor gene PTEN. Cowden syndrome and Bannayan–Riley–Ruvalcaba syndrome are representative diseases, and both have several common clinical features and differences. Because PTEN mutations are associated with an increased risk of malignancy including breast, thyroid, endometrial, and renal cancers, cancer surveillance is an important element of disease management. We report a germline mutation of the PTEN (c.723dupT, exon 7) identified in a young woman with a simultaneous occurrence of breast cancer, dermatofibrosarcoma protuberans, and follicular neoplasm. This case suggests that it is critical for clinicians to recognize the phenotypic features associated with these syndromes to accurately diagnose them and provide preventive care.

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Breast Cancer with a Newly Diagnosed Variant in the PTEN Gene: A Case Report
Yuka Maeda, Tatsuhiko Ikeda, Ayana Sato, Akiko Matsumoto, Hiromitsu Jinno
Surgical Case Reports.2025; 11(1): n/a. CrossRef
Synchronous and metachronous thyroid cancer, breast cancer, and melanoma in a premenopausal patient with Cowden syndrome
Belinda Asare, Babita Panigrahi
Radiology Case Reports.2023; 18(5): 1918. CrossRef
Molecular Action of Herbal Antioxidants in Regulation of Cancer Growth: Scope for Novel Anticancer Drugs
Manjula Vinayak
Nutrition and Cancer.2018; 70(8): 1199. CrossRef

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Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy: Su Lim Lee, Eun Deok Chang, Sae Jung Na, Jeong Soo Kim, Ho Jung An, Yoon Ho Ko, Hye Sung Won; Cancer Res Treat. 2014;46(1):98-103. Published online January 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.1.98

Abstract PDF PubReader ePub

Pseudocirrhosis refers to a condition that shows changes in hepatic contour that mimic cirrhosis radiographically in the absence of the typical histopathological findings of cirrhosis. This condition has been observed in patients with cancer metastatic to the liver, both in those who have undergone prior systemic chemotherapy and those who have not. Pseudocirrhosis may cause difficulty in interpretation of the response to chemotherapy and hepatic decompression and complication of portal hypertension have a negative effect on the prognosis. We report on a case of breast cancer with liver metastases that showed cirrhotic changes during disease progression. Progression of liver metastases was confirmed by F18 fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT). We also performed ultrasound-guided liver biopsy and confirmed tumor infiltration with severe desmoplastic fibrosis. This case suggests the pathogenesis of pseudocirrhosis through histopathological findings and the role of PET-CT in evaluation of the response to chemotherapy in patients with pseudocirrhosis.

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Pseudocirrhosis: A Case Series with Clinical and Radiographic Correlation and Review of the Literature
Gal Sadlik, Redmond-Craig Anderson, Xiaomeng Lei, Steven Yong Cen, Vinay A. Duddalwar, Tse-Ling Fong
Digestive Diseases and Sciences.2024; 69(3): 1004. CrossRef
Clinical characteristics and outcomes in patients with metastatic breast cancer and pseudocirrhosis: a single center retrospective cohort study
Laura A. Huppert, Zak Walker, Moming Li, Mi-Ok Kim, Jennifer Callan, Danielle Brandman, Melanie Majure, Michelle E. Melisko, Hope S. Rugo, Spencer Behr, A. Jo Chien
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Dione Lother, Marie Robert, Elliot Elwood, Sam Smith, Nina Tunariu, Stephen R.D. Johnston, Marina Parton, Basrull Bhaludin, Thomas Millard, Kate Downey, Bhupinder Sharma
Cancer Imaging.2023;[Epub] CrossRef
Pseudocirrhosis Due to Desmoplastic Response to Chemotherapy in Breast Cancer Liver Metastases
Kazuhide Takata, Ai Mogi, Ryo Yamauchi, Satoshi Shakado, Fumihito Hirai
Cureus.2022;[Epub] CrossRef
Liver Metastases: Correlation between Imaging Features and Pathomolecular Environments
Kumi Ozaki, Shohei Higuchi, Hirohiko Kimura, Toshifumi Gabata
RadioGraphics.2022; 42(7): 1994. CrossRef
Clinical Outcomes of Metastatic Breast Cancer in Patients Having Imaging Liver Pseudocirrhosis with or without Evident Varices
Wei-Li Ma, Dwan-Ying Chang, Ching-Hung Lin, Kao-Lang Liu, Po-Chin Liang, Huang-Chun Lien, Chan-Chuan Hu, Ling-Yun Huang, Yi-Chun Yeh, Yen-Shen Lu
The Oncologist.2022; 27(12): 1008. CrossRef
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Rosanna Villani, Francesca Di Cosimo, Moris Sangineto, Antonino Davide Romano, Gaetano Serviddio
Scientific Reports.2022;[Epub] CrossRef
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Dharmesh Gopalakrishnan, Ain Shajihan, Andrei S. Purysko, Jame Abraham
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Tomohito Shinoda, Toshiyuki Tanahashi, Takuji Sakuratani, Masato Ota, Seito Fujibayashi, Shunya Kiriyama, Keita Matsumoto, Kazunori Yawata, Yoshiyuki Sasaki, Shinji Osada, Makoto Yamada
Molecular and Clinical Oncology.2021;[Epub] CrossRef
Imaging of the chemotherapy-induced hepatic damage: Yellow liver, blue liver, and pseudocirrhosis
Linda Calistri, Vieri Rastrelli, Cosimo Nardi, Davide Maraghelli, Sofia Vidali, Michele Pietragalla, Stefano Colagrande
World Journal of Gastroenterology.2021; 27(46): 7866. CrossRef
Clinical features of pseudocirrhosis in metastatic breast cancer
Caspian Oliai, Michael L. Douek, Caelainn Rhoane, Abhishek Bhutada, Phillip S. Ge, Bruce A. Runyon, Xiaoyan Wang, Sara A. Hurvitz
Breast Cancer Research and Treatment.2019; 177(2): 409. CrossRef
Seudocirrosis en cáncer de mama metastásico
Alba Hidalgo-Blanco, Maddi Aguirresarobe-Gil de San Vicente, Santi Aresti, Eduardo de Miguel, Jose Luis Cabriada-Nuno
Gastroenterología y Hepatología.2018; 41(2): 111. CrossRef
Pseudocirrhosis in metastatic breast cancer
Alba Hidalgo-Blanco, Maddi Aguirresarobe-Gil de San Vicente, Santi Aresti, Eduardo de Miguel, Jose Luis Cabriada-Nuno
Gastroenterología y Hepatología (English Edition).2018; 41(2): 111. CrossRef
Pseudocirrhosis after chemotherapy in breast cancer, case reports
Tomoyoshi Aoyagi, Kazuaki Takabe, Tamaki Tamanuki, Hisahiro Matsubara, Hiroshi Matsuzaki
Breast Cancer.2018; 25(5): 614. CrossRef
Unintended Consequences of Systemic and Ablative Oncologic Therapy in the Abdomen and Pelvis
Julie C. Birch, Gaurav Khatri, Lori M. Watumull, Yull E. Arriaga, John R. Leyendecker
RadioGraphics.2018; 38(4): 1158. CrossRef
Transjugular Intrahepatic Portosystemic Shunt for the Treatment of Portal Hypertension-Induced Refractory Ascites Due to Metastatic Carcinomatous Liver Disease
Barbara Geeroms, Gert De Hertogh, Ragna Vanslembrouck, Hans Wildiers, Frederik Nevens, Geert Maleux
Journal of Vascular and Interventional Radiology.2018; 29(12): 1713. CrossRef
Delineating Extramammary Findings at Breast MR Imaging
Yiming Gao, Opeyemi Ibidapo, Hildegard K. Toth, Linda Moy
RadioGraphics.2017; 37(1): 10. CrossRef
Pseudocirrhosis caused by regorafenib in an advanced rectal cancer patient with multiple liver metastases
Kensuke Kumamoto, Shungo Endo, Noriyuki Isohata, Azuma Nirei, Daiki Nemoto, Kenichi Utano, Takuro Saito, Kazutomo Togashi
Molecular and Clinical Oncology.2017; 6(1): 63. CrossRef
Systemic treatment in breast cancer: a primer for radiologists
Aya Y. Michaels, Abhishek R. Keraliya, Sree Harsha Tirumani, Atul B. Shinagare, Nikhil H. Ramaiya
Insights into Imaging.2016; 7(1): 131. CrossRef
Causes of hepatic capsular retraction: a pictorial essay
Gary Xia Vern Tan, Rhian Miranda, Tom Sutherland
Insights into Imaging.2016; 7(6): 831. CrossRef
Pseudocirrhosis in Gastric Cancer with Diffuse Liver Metastases after a Dramatic Response to Chemotherapy
Seiichiro Mitani, Shigenori Kadowaki, Hiroya Taniguchi, Hisanori Muto, Kei Muro
Case Reports in Oncology.2016; 9(1): 106. CrossRef
Pseudocirrhosis: A Case Series and Literature Review
Abimbola Adike, Nina Karlin, Christine Menias, Elizabeth J. Carey
Case Reports in Gastroenterology.2016; 10(2): 381. CrossRef
Cancer therapy related complications in the liver, pancreas, and biliary system: an imaging perspective
Danny Ngo, Jemianne Bautista Jia, Christopher S. Green, Anjalie T. Gulati, Chandana Lall
Insights into Imaging.2015; 6(6): 665. CrossRef
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Rui-Jun Ju, Xue-Tao Li, Ji-Feng Shi, Xiu-Ying Li, Meng-Ge Sun, Fan Zeng, Jia Zhou, Lei Liu, Cheng-Xiang Zhang, Wei-Yu Zhao, Wan-Liang Lu
Biomaterials.2014; 35(26): 7610. CrossRef

15,923 View
179 Download
26 Web of Science
25 Crossref

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