Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
3 "Min Chul Cho"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Genitourinary cancer
A Nationwide Study of Differences in Surgical Treatment Rates and Oncological Outcomes for Prostate Cancer according to Economic Status and Region
Sangjun Yoo, Sohee Oh, Min Chul Cho, Hwancheol Son, Hyeon Jeong
Cancer Res Treat. 2023;55(2):652-658.   Published online December 12, 2022
DOI: https://doi.org/10.4143/crt.2022.893
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
We investigated the effects of economic status (classified based on insurance type and residential area) on oncological outcomes of prostate cancer using a nationwide database. We additionally investigated oncological outcomes based on economic status and residential area in patients who underwent surgical treatment.
Materials and Methods
The study included 75,518 men with newly diagnosed prostate cancer between 2009 and 2018 in whom oncological outcomes were investigated based on economic status and residential area. Among the 75,518 men with prostate cancer, the data of 29,973 men who underwent radical prostatectomy were further analyzed. Multivariate analysis was performed to determine the effects of economic status and residential area on postoperative oncological outcomes.
Results
Among the 75,518 patients with prostate cancer, 3,254 (4.31%) were medical aid beneficiaries. The 5-year overall survival rates were 81.2% and 64.8% in the health insurance and medical aid groups, respectively. Radical prostatectomy was more common in the health insurance group, and surgical intervention was significantly affected by the residential area. Among patients who underwent surgery, 5-year androgen deprivation therapy–free and overall survival were better in the health insurance group. Multivariate analysis showed that insurance type and residential area were significantly associated with the androgen deprivation therapy–free and overall survival after adjustment for other variables.
Conclusion
Economic status and residential area were shown to affect not only treatment patterns but also post-diagnosis and postoperative oncological outcomes. Political support for early diagnosis and appropriate treatment of prostate cancer is warranted for medically vulnerable populations.
  • 4,228 View
  • 126 Download
Close layer
Gynecologic cancer
Frequency of Mismatch Repair Deficiency/High Microsatellite Instability and Its Role as a Predictive Biomarker of Response to Immune Checkpoint Inhibitors in Gynecologic Cancers
Joseph J. Noh, Min Kyu Kim, Min Chul Choi, Jeong-Won Lee, Hyun Park, Sang Geun Jung, Won Duk Joo, Seung Hun Song, Chan Lee
Cancer Res Treat. 2022;54(4):1200-1208.   Published online December 13, 2021
DOI: https://doi.org/10.4143/crt.2021.828
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study was to investigate the frequency of mismatch repair deficiency/high microsatellite instability (MMRd/MSI-H) in gynecologic malignancies and the efficacy of immune checkpoint inhibitors (ICIs) in patients with recurrent gynecologic cancers according to MMR/MSI status.
Materials and Methods
We conducted a multi-center retrospective review on the patients who were diagnosed with gynecologic cancers between 2015 and 2020. Their clinicopathologic information, results of immunohistochemistry staining for MLH1/MSH2/MSH6/PMS2 and MSI analysis, tumor response to treatment with ICIs were investigated.
Results
Among 1,093 patients included in the analysis, MMRd/MSI-H was most frequent in endometrial/uterine cancers (34.8%, 164/471), followed by ovarian, tubal, and peritoneal cancers (12.8%, 54/422) and cervical cancer (11.3%, 21/186). When assessed by histology without regard for cancer types, the frequency of MMRd/MSI-H was 11.0% (38/345) in high-grade serous adenocarcinoma, 38.6% (117/303) in endometrioid adenocarcinoma, and 30.2% (16/53) in carcinosarcoma. A total of 114 patients were treated with ICIs at least once. The objective response rate (ORR) was 21.6% (8/37) in cervical cancer, 4.7% (2/43) in ovarian cancer, and 25.8% (8/31) in endometrial/uterine cancers. Univariate regression analysis identified MMRd/MSI-H as the only significant factor associated with the ORR (28.9% [11/38] vs. 11.8% [9/76]; odds ratio, 3.033; 95% confidence interval, 1.129–8.144; p=0.028).
Conclusion
The frequency of MMRd/MSI-H is moderate to high in gynecologic cancers in the Korean population. MMRd/MSI-H could be effective predictive biomarkers in gynecologic cancers of any type.

Citations

Citations to this article as recorded by  
  • Immunotherapy plus chemotherapy in patients with advanced endometrial cancer: a cost-effectiveness analysis
    Youwen Zhu, Kun Liu, Hong Zhu
    Journal of Gynecologic Oncology.2025;[Epub]     CrossRef
  • Cervical lymphoepithelioma-like carcinoma with deficient mismatch repair and loss of SMARCA4/BRG1: a case report and five related cases
    Yu Miyama, Tomomi Kato, Masayasu Sato, Akira Yabuno, Kosei Hasegawa, Masanori Yasuda
    Diagnostic Pathology.2024;[Epub]     CrossRef
  • Prognostic factors of 87 ovarian yolk sac tumor (OYST) patients and molecular characteristics of persistent and recurrent OYST
    Shanhui Liang, Huijuan Ge, Shuling Zhou, Jie Tang, Yanzi Gu, Xiaohua Wu, Jin Li
    Gynecologic Oncology.2024; 187: 64.     CrossRef
  • Immunotherapy in MMR-d/MSI-H recurrent/metastatic endometrial cancer
    Renata Pacholczak-Madej, Michele Bartoletti, Lucia Musacchio, Mirosława Püsküllüoglu, Paweł Blecharz, Domenica Lorusso
    Expert Review of Anticancer Therapy.2024; 24(8): 717.     CrossRef
  • Expression patterns of mismatch repair proteins in cervical cancer uncover independent prognostic value of MSH-2
    Madeleine Charlotte van den Berg, Hege F Berg, Tomasz Stokowy, Erling A Hoivik, Kathrine Woie, Hilde Engerud, Akinyemi I Ojesina, Ingfrid Salvesen Haldorsen, Jone Trovik, Bjørn I Bertelsen, Camilla Krakstad, Mari Kyllesø Halle, Janie Foote
    International Journal of Gynecological Cancer.2024; 34(7): 993.     CrossRef
  • Cervical cancer: a new era
    Giuseppe Caruso, Matthew K Wagar, Heng-Cheng Hsu, Jorge Hoegl, Guido Martin Rey Valzacchi, Andreina Fernandes, Giuseppe Cucinella, Seda Sahin Aker, Aarthi S Jayraj, Jessica Mauro, Rene Pareja, Pedro T Ramirez
    International Journal of Gynecological Cancer.2024; 34(12): 1946.     CrossRef
  • Unraveling the Heterogeneity of Deficiency of Mismatch Repair Proteins in Endometrial Cancer: Predictive Biomarkers and Assessment Challenges
    Filomena M. Carvalho, Jesus P. Carvalho
    Cancers.2024; 16(20): 3452.     CrossRef
  • Long-term benefit of immunotherapy in a patient with squamous lung cancer exhibiting mismatch repair deficient/high microsatellite instability/high tumor mutational burden: A case report and literature review
    Na Li, Zixuan Wan, Dongyan Lu, Ruilian Chen, Xiaowei Ye
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
    Guillaume Mestrallet, Matthew Brown, Cansu Cimen Bozkus, Nina Bhardwaj
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Heterogeneous expression of mismatch repair proteins and interpretation of immunohistochemical results in colorectal cancer and endometrial cancer
    Xiangzhao Li, Shifen Zhang, Jiamin Zeng, Sha-sha Song, Xiaoqing Liu, Wei Kang, Minyi Liang, Rui Yang, Hong Li, Li Liang
    Pathology - Research and Practice.2023; 248: 154647.     CrossRef
  • Rechallenge with Anti-PD-1 Inhibitors in Patients with Recurrent Gynecologic Malignancies
    Migang Kim, Chi-Son Chang, Min Chul Choi, Jeong-Won Lee, Hyun Park, Won Duk Joo
    Yonsei Medical Journal.2023; 64(10): 587.     CrossRef
  • Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature
    Linlin Liu, Xianbo Deng, Shuang Guo, Shouhua Yang
    Diagnostic Pathology.2023;[Epub]     CrossRef
  • Adverse Effect of the Duration of Antibiotic Use Prior to Immune Checkpoint Inhibitors on the Overall Survival of Patients with Recurrent Gynecologic Malignancies
    Hye-Ji Jung, Jong-Ho Park, Jina Oh, Sae-Mi Lee, Il-Yeo Jang, Jung-Yong Hong, Yoo-Young Lee, Hyun Jin Choi
    Cancers.2023; 15(24): 5745.     CrossRef
  • Uterine carcinosarcoma with microsatellite instability - does immunotherapy modify the therapeutic scenario? A case report and literature review
    Diocesio Alves Pinto Andrade, Eduardo Paulino, Isabela Panzeri Carlotti Buzatto, Danilo Tadao Wada, Warne Pedro Andrade, Andreia Cristina Melo, Angelica Nogueira-Rodrigues
    Brazilian Journal of Oncology.2023;[Epub]     CrossRef
  • Immune checkpoint inhibitors in cervical cancer: Current status and research progress
    Yunkai Xie, Weimin Kong, Xiaoling Zhao, He Zhang, Dan Luo, Shuning Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • 7,011 View
  • 296 Download
  • 16 Web of Science
  • 15 Crossref
Close layer
Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma
Min Chul Choi, Sohyun Hwang, Sewha Kim, Sang Geun Jung, Hyun Park, Won Duk Joo, Seung Hun Song, Chan Lee, Tae-Heon Kim, Haeyoun Kang, Hee Jung An
Cancer Res Treat. 2020;52(2):634-644.   Published online January 6, 2020
DOI: https://doi.org/10.4143/crt.2019.207
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
In this study, we investigated the frequencies of mutations in DNA damage repair genes including BRCA1, BRCA2, homologous recombination genes and TP53 gene in ovarian high-grade serous carcinoma, alongside those of germline and somatic BRCA mutations, with the aim of improving the identification of patients suitable for treatment with poly(ADP-ribose) polymerase inhibitors.
Materials and Methods
Tissue samples from 77 Korean patients with ovarian high-grade serous carcinoma were subjected to next-generation sequencing. Pathogenic alterations of 38 DNA damage repair genes and TP53 gene and their relationships with patient survival were examined. Additionally, we analyzed BRCA germline variants in blood samples from 47 of the patients for comparison.
Results
BRCA1, BRCA2, and TP53 mutations were detected in 28.6%, 5.2%, and 80.5% of the 77 patients, respectively. Alterations in RAD50, ATR, MSH6, MSH2, and FANCA were also identified. At least one mutation in a DNA damage repair gene was detected in 40.3% of patients (31/77). Germline and somatic BRCA mutations were found in 20 of 47 patients (42.6%), and four patients had only somatic mutations without germline mutations (8.5%, 4/47). Patients with DNA damage repair gene alterations with or without TP53mutation, exhibited better disease-free survival than those with TP53 mutation alone.
Conclusion
DNA damage repair genes were mutated in 40.3% of patients with high-grade serous carcinoma, with somatic BRCA mutations in the absence of germline mutation in 8.5%. Somatic variant examination, along with germline testing of DNA damage repair genes, has potential to detect additional candidates for PARP inhibitor treatment.

Citations

Citations to this article as recorded by  
  • Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms
    Harshavardhani Canchi Sistla, Srikanth Talluri, Taruna Rajagopal, Sivaramakrishnan Venkatabalasubramanian, Nageswara Rao Dunna
    Clinica Chimica Acta.2025; 565: 119992.     CrossRef
  • BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer
    Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina de Armas, Fábio Carvalho de Barros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dos Santos, Miguel Angelo Martins Mor
    Cancer Medicine.2024;[Epub]     CrossRef
  • Proteomic landscape of epithelial ovarian cancer
    Liujia Qian, Jianqing Zhu, Zhangzhi Xue, Yan Zhou, Nan Xiang, Hong Xu, Rui Sun, Wangang Gong, Xue Cai, Lu Sun, Weigang Ge, Yufeng Liu, Ying Su, Wangmin Lin, Yuecheng Zhan, Junjian Wang, Shuang Song, Xiao Yi, Maowei Ni, Yi Zhu, Yuejin Hua, Zhiguo Zheng, Ti
    Nature Communications.2024;[Epub]     CrossRef
  • T-Cell Receptor Repertoire Characteristics Associated with Prognostic Significance in High-Grade Serous Ovarian Carcinoma
    Ju-Won Kim, Sewha Kim, So-Yun Yang, Je-Gun Joung, Sohyun Hwang
    Genes.2023; 14(4): 785.     CrossRef
  • Potential prognostic role of somatic mutations in a set of cancer susceptibility genes in ovarian carcinoma: A follow-up multicentric study from Pakistan
    Atika Masood, Rahat Sarfaraz, Saima Zaki, Amira Shami, Saba Khaliq, Nadia Naseem
    Cancer Biomarkers.2023; 36(3): 207.     CrossRef
  • Deleterious and ethnic-related BRCA1/2 mutations in tissue and blood of Egyptian colorectal cancer patients and its correlation with human papillomavirus
    Amira Salah El-Din Youssef, Abdel Rahman N. Zekri, Marwa Mohanad, Samah A. Loutfy, Nasra F. Abdel Fattah, Mostafa H. Elberry, Asmaa A. El Leithy, Ahmed El-Touny, Ahmed Samy Rabie, Mohamed Shalaby, Ayman Hanafy, Mai M. Lotfy, Enas R. El-sisi, Gharieb S. El
    Clinical and Experimental Medicine.2023; 23(8): 5063.     CrossRef
  • SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells
    Ka‐Kui Chan, Zahi Abdul‐Sater, Aditya Sheth, Dana K. Mitchell, Richa Sharma, Donna M. Edwards, Ying He, Grzegorz Nalepa, Steven D. Rhodes, D. Wade Clapp, Elizabeth A. Sierra Potchanant
    Molecular Oncology.2022; 16(4): 860.     CrossRef
  • Somatic genomic landscape of East Asian epithelial ovarian carcinoma and its clinical implications from prospective clinical sequencing: A Korean Gynecologic Oncology Group study (KGOG 3047)
    Jason K. Sa, Jihye Kim, Sokbom Kang, Sang Wun Kim, Taejong Song, Seung‐Hyuk Shim, Min Chul Choi, Jae Hong No, Jae‐Yun Song, Deokhoon Kim, Yong‐Man Kim, Jae‐Hoon Kim, Jeong‐Won Lee
    International Journal of Cancer.2022; 151(7): 1086.     CrossRef
  • Analysis of Novel Variants Associated with Three Human Ovarian Cancer Cell Lines
    Venugopala Reddy Mekala, Jan-Gowth Chang, Ka-Lok Ng
    Current Bioinformatics.2022; 17(4): 380.     CrossRef
  • Genomic profiling of platinum-resistant ovarian cancer: The road into druggable targets
    Alexandre André Balieiro Anastácio da Costa, Glauco Baiocchi
    Seminars in Cancer Biology.2021; 77: 29.     CrossRef
  • The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study
    Angela Toss, Claudia Piombino, Elena Tenedini, Alessandra Bologna, Elisa Gasparini, Vittoria Tarantino, Maria Elisabetta Filieri, Luca Cottafavi, Filippo Giovanardi, Stefano Madrigali, Monica Civallero, Luigi Marcheselli, Isabella Marchi, Federica Domati,
    Diagnostics.2021; 11(3): 565.     CrossRef
  • USP19 and RPL23 as Candidate Prognostic Markers for Advanced-Stage High-Grade Serous Ovarian Carcinoma
    Haeyoun Kang, Min Chul Choi, Sewha Kim, Ju-Yeon Jeong, Ah-Young Kwon, Tae-Hoen Kim, Gwangil Kim, Won Duk Joo, Hyun Park, Chan Lee, Seung Hun Song, Sang Geun Jung, Sohyun Hwang, Hee Jung An
    Cancers.2021; 13(16): 3976.     CrossRef
  • Summary of BARD1 Mutations and Precise Estimation of Breast and Ovarian Cancer Risks Associated with the Mutations
    Malwina Suszynska, Piotr Kozlowski
    Genes.2020; 11(7): 798.     CrossRef
  • Prevalence of pathogenic variants in actionable genes in advanced ovarian cancer: a next-generation sequencing analysis of a nationwide registry study
    Sokbom Kang, Ye L. Yu, Soo Y. Cho, Seog-Yun Park
    European Journal of Cancer.2020; 141: 185.     CrossRef
  • PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality—An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness
    Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak, Michał Mikuła, Jerzy Ostrowski, Agnieszka Śliwińska, Aneta Rogalska
    International Journal of Molecular Sciences.2020; 21(24): 9715.     CrossRef
  • 10,405 View
  • 293 Download
  • 15 Web of Science
  • 15 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP