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Case Report
An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression
Hye Seon Kang, Hea Yon Lee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Gyeong Sin Park, Kyo Young Lee, Jung Im Jung, Ji Young Kang
Cancer Res Treat. 2015;47(4):943-948.   Published online September 15, 2014
DOI: https://doi.org/10.4143/crt.2014.016
AbstractAbstract PDFPubReaderePub
A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course.

Citations

Citations to this article as recorded by  
  • Surgery and chemotherapy cannot improve the survival of patients with early-stage mucosa-associated lymphoid tissue derived primary pulmonary lymphoma
    Huahang Lin, Ke Zhou, Zhiyu Peng, Linchuan Liang, Jie Cao, Jiandong Mei
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Abscopal Regressions of Lymphoma After Involved-Site Radiation Therapy Confirmed by Positron Emission Tomography
    Michael P. MacManus, Michael S. Hofman, Rodney J. Hicks, Belinda A. Campbell, Andrew Wirth, John F. Seymour, Nicole Haynes, Kate Burbury
    International Journal of Radiation Oncology*Biology*Physics.2020; 108(1): 204.     CrossRef
  • Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma with Spontaneous Regression after Computed Tomography-guided Needle Biopsy: A Case Report and Summary of 8 Reported Cases
    Kazuaki Fukushima, Susumu Hirosako, Yuki Tenjin, Yosuke Mukasa, Keisuke Kojima, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu, Kazuhiko Fujii, Yoshitaka Kikukawa, Koichi Kawanaka, Hirotsugu Kohrogi
    Internal Medicine.2016; 55(24): 3655.     CrossRef
  • A Rare Radiological Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Bronchovascular Thickening and Ground Glass Opacities with Concurrent Pancreas Involvement
    Yun Mi Kwak, Ho Sung Lee, Ki Hyun Seo, Ji Won Lyu, Si-Hyong Jang, Ju Ock Na
    Soonchunhyang Medical Science.2016; 22(2): 151.     CrossRef
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Original Articles
Predicting Survival in Patients with Advanced Non-squamous Non-small Cell Lung Cancer: Validating the Extent of Metastasis
Dong Soo Lee, Jin Hyoung Kang, Chang Geol Lee, Seoung Jun Kim, Young Jin Choi, Kyo Young Lee, Yeon Sil Kim
Cancer Res Treat. 2013;45(2):95-102.   Published online June 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.2.95
AbstractAbstract PDFPubReaderePub
PURPOSE
A number of factors related to overall survival (OS) have been addressed in advanced non-small cell lung cancer (NSCLC). This study was conducted to determine the impact of whole-body metastatic regions on survival outcome in advanced non-squamous NSCLC.
MATERIALS AND METHODS
Between March 2005 and February 2011, 112 eligible patients with newly confirmed stage IV non-squamous NSCLC, available for epidermal growth factor receptor (EGFR) mutation status 18-21 analysis, and accessible for the determination of pretreatment whole-body metastatic regions were enrolled in this retrospective study. The total number of synchronous metastatic regions was scored according to the following disease sites: abdomen/pelvis, lung to lung/pulmonary lymphangitic spread, bone, pleura/pleural effusion/pericardial effusion, neck/axillary lymph nodes, other soft tissue, brain.
RESULTS
The median age of the cohort was 65 years (range, 31 to 88 years). The median whole-body metastatic score was 2 (range, 1 to 6), and bone and lung to lung were the most common metastatic sites. EGFR mutations were observed in 40 (35.7%) patients with a deletion in exon 19 and Leu858Arg mutation in exon 21 being detected in 16 (40.0%) and 19 (47.5%) patients, respectively. Multivariate analysis for OS revealed that treatment factors (p=0.005), performance status (p=0.006), whole-body metastatic score (p<0.001), and EGFR mutation status (p=0.095) were significantly or marginally associated with OS.
CONCLUSION
The results of the present study demonstrated that whole-body metastatic extent strongly affects survival outcome, even after adjustment for other significant variables in advanced non-squamous NSCLC. The clinical validity of more curative multimodal approaches in cohorts with limited metastases remains to be explored.

Citations

Citations to this article as recorded by  
  • Clathrin‐mediated EGFR endocytosis as a potential therapeutic strategy for overcoming primary resistance of EGFR TKI in wild‐type EGFR non‐small cell lung cancer
    Boyeon Kim, Young Soo Park, Jae Sook Sung, Jong Won Lee, Saet Byeol Lee, Yeul Hong Kim
    Cancer Medicine.2021; 10(1): 372.     CrossRef
  • Modified Glasgow Prognostic Score predicts survival among advanced non-small cell lung carcinoma patients treated with anti-PD1 agents
    Cláudia Freitas, Maria Jacob, Nuno Tavares, Natália Cruz-Martins, Conceição Souto-Moura, David Araújo, Hélder Novais-Bastos, Vanessa Santos, Gabriela Fernandes, Adriana Magalhães, Venceslau Hespanhol, Henrique Queiroga
    Anti-Cancer Drugs.2021; 32(5): 567.     CrossRef
  • O impacto da histologia do carcinoma pulmonar na frequência das metástases ósseas
    Marcelo Bragança dos Reis Oliveira, Larissa Costa Souza, Ermides Javier Garcia Sampayo, Gustavo Sobral de Carvalho, Fernanda Carvalho de Queiroz Mello, Marcos Eduardo Machado Paschoal
    Revista Brasileira de Ortopedia.2019; 54(05): 524.     CrossRef
  • Brain Metastases at Presentation in Patients With Non–Small Cell Lung Cancer
    Saiama N. Waqar, Sadaf H. Waqar, Kathryn Trinkaus, Carlos A. Gadea, Cliff G. Robinson, Jeffrey Bradley, Mark A. Watson, Varun Puri, Ramaswamy Govindan, Daniel Morgensztern
    American Journal of Clinical Oncology.2018; 41(1): 36.     CrossRef
  • Differential effects of two therapeutic cancer vaccines on short- and long-term survival populations among patients with advanced lung cancer
    Lizet Sanchez, Leacky Muchene, Patricia Lorenzo-Luaces, Carmen Viada, Pedro C. Rodriguez, Sailyn Alfonso, Tania Crombet, Elia Neninger, Ziv Shkedy, Agustin Lage
    Seminars in Oncology.2018; 45(1-2): 52.     CrossRef
  • Impact of number versus location of metastases on survival in stage IV M1b non-small cell lung cancer
    Amanda Jane Williams Gibson, Haocheng Li, Adrijana D’Silva, Roxana A. Tudor, Anifat A. Elegbede, Shannon Mary Otsuka, D. Gwyn Bebb, Winson Y. Cheung
    Medical Oncology.2018;[Epub]     CrossRef
  • PATHOLOGICAL FRACTURES DUE TO BONE METASTASES FROM LUNG CANCER: RISK FACTORS AND SURVIVAL
    Marcelo Bragança dos Reis Oliveira, Bruno de Carvalho Marques, Rosa Aurílio Matos, César Rubens da Costa Fontenelle, Fernanda Carvalho de Queiroz Mello, Marcos Eduardo Machado Paschoal
    Acta Ortopédica Brasileira.2018; 26(6): 388.     CrossRef
  • Serum lactate dehydrogenase levels at presentation in stage IV non-small cell lung cancer: predictive value of metastases and relation to survival outcomes
    Dong Soo Lee, Kyung Ran Park, Seung Joon Kim, Mi Joo Chung, Yun Hee Lee, Ji Hyun Chang, Jin Hyoung Kang, Sook Hee Hong, Myung Sin Kim, Yeon Sil Kim
    Tumor Biology.2016; 37(1): 619.     CrossRef
  • Distinctive Patterns of Initially Presenting Metastases and Clinical Outcomes According to the Histological Subtypes in Stage IV Non-Small Cell Lung Cancer
    Dong Soo Lee, Yeon S. Kim, Chul S. Kay, Sung H. Kim, Chang D. Yeo, Jin W. Kim, Seung Joon Kim, Young K. Kim, Yoon H. Ko, Jin H. Kang, Kyo Y. Lee
    Medicine.2016; 95(6): e2795.     CrossRef
  • Rare occurrence of cavitation of lung metastases following effective targeted therapy: A case report
    JIACHENG SONG, JING YU, ZHANLONG MA, SHANSHAN LU
    Oncology Letters.2016; 11(2): 1589.     CrossRef
  • Is second-line systemic chemotherapy beneficial in patients with non-small cell lung cancer (NSCLC)? A multicenter data evaluation by the Anatolian Society of Medical Oncology
    Hatice Odabas, Arife Ulas, Kubra Aydin, Mevlude Inanc, Asude Aksoy, Dogan Yazilitas, Mehmet Turkeli, Sinemis Yuksel, Ali Inal, Ahmet S. Ekinci, Alper Sevinc, Nebi S. Demirci, Mukremin Uysal, Necati Alkis, Faysal Dane, Mehmet Aliustaoglu, Mahmut Gumus
    Tumor Biology.2015; 36(12): 9641.     CrossRef
  • Clinical Correlation Between Tumor Maximal Standardized Uptake Value in Metabolic Imaging and Metastatic Tumor Characteristics in Advanced Non-small Cell Lung Cancer
    Dong Soo Lee, Seung Joon Kim, Hong Seok Jang, Ie Ryung Yoo, Kyung Ran Park, Sae Jung Na, Kyo Young Lee, Sook Hee Hong, Jin Hyoung Kang, Young Kyoon Kim, Yeon Sil Kim
    Medicine.2015; 94(32): e1304.     CrossRef
  • A case of lung cancer complicated by axillary Castleman's disease
    Manabu Kakizoe, Kousuke Suzuki, Noriyuki Saeki
    The Journal of the Japanese Association for Chest Surgery.2015; 29(6): 722.     CrossRef
  • Non-small cell lung cancer metastasis to the oral cavity: a case report
    JB Olsen, F Sim, A Chandu
    Australian Dental Journal.2014; 59(4): 520.     CrossRef
  • Lung Cancer Coexisting With Ipsilateral Pleural Effusion
    Francisco Rodriguez-Panadero, Beatriz Romero-Romero
    Lung Cancer Management.2014; 3(4): 335.     CrossRef
  • EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR
    Ukhyun Jo, Kyong Hwa Park, Young Mi Whang, Jae Sook Sung, Nam Hee Won, Jong Kuk Park, Yeul Hong Kim
    Oncotarget.2014; 5(5): 1265.     CrossRef
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Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and -D in Resected Non-Small Cell Lung Cancer
Yoon Ho Ko, Chan-Kwon Jung, Myung-Ah Lee, Jae Ho Byun, Jin Hyoung Kang, Kyo Young Lee, Keon Hyun Jo, Young Pil Wang, Young Seon Hong
Cancer Res Treat. 2008;40(3):133-140.   Published online September 30, 2008
DOI: https://doi.org/10.4143/crt.2008.40.3.133
AbstractAbstract PDFPubReaderePub
Purpose

Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play important roles in lymphangiogenesis via the VEGF receptor 3 (VEGFR-3). We sought to determine whether VEGF-C, VEGF-D and VEGFR-3 are involved in the clinical outcomes of patients with resected NSCLC.

Materials and Methods

Using immunohistochemical staining, we investigated the protein expressions of VEGF-C, VEGF-D and VEGFR-3 in the tissue array specimens from patients who underwent resection for NSCLC. The immunoreactivity for p53 was also examined. The clinicopathological implications of these molecules were statistically analyzed.

Results

Analysis of a total of 118 specimens showed that VEGF-C, VEGF-D and their co-expression were significantly associated with more advanced regional lymph node metastasis (p=0.019, p=0.044 and p=0.026, respectively, N2 versus N0 and N1). A VEGFR-3 expression had a strong correlation with peritumoral lymphatic invasion (p=0.047). On the multivariate analysis for survival and recurrence, pathologic N2 lymph node metastasis was the only independent prognostic factor, but none of the investigated molecules showed any statistical correlation with recurrence and survival.

Conclusions

The present study revealed that high expressions of VEGF-C and VEGF-D were strongly associated with more advanced regional lymph node metastasis in patients with resected NSCLC.

Citations

Citations to this article as recorded by  
  • Advances in lymphatic metastasis of non-small cell lung cancer
    Xiaofei Zhang, Li Ma, Man Xue, Yanning Sun, Zhaoxia Wang
    Cell Communication and Signaling.2024;[Epub]     CrossRef
  • Prediction of VEGF and EGFR Expression in Peripheral Lung Cancer Based on the Radiomics Model of Spectral CT Enhanced Images
    Linhua Wu, Jian Li, Xiaowei Ruan, Jialiang Ren, Xuejun Ping, Bing Chen
    International Journal of General Medicine.2022; Volume 15: 6725.     CrossRef
  • Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis
    Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou, Changyan Chen
    BMC Cancer.2015;[Epub]     CrossRef
  • Prognostic Impact of Elevation of Vascular Endothelial Growth Factor Family Expression in Patients with Non-small Cell lung Cancer: an Updated Meta-analysis
    Chun-Long Zheng, Chen Qiu, Mei-Xiao Shen, Xiao Qu, Tie-Hong Zhang, Ji-Hong Zhang, Jia-Jun Du
    Asian Pacific Journal of Cancer Prevention.2015; 16(5): 1881.     CrossRef
  • Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer - A Structured Review with Meta-Analysis
    Thomas K. Kilvaer, Erna-Elise Paulsen, Sigurd M. Hald, Tom Wilsgaard, Roy M. Bremnes, Lill-Tove Busund, Tom Donnem, Xin-Yuan Guan
    PLOS ONE.2015; 10(8): e0132481.     CrossRef
  • A Gene Signature Combining the Tissue Expression of Three Angiogenic Factors is a Prognostic Marker in Early-stage Non-small Cell Lung Cancer
    Elena Sanmartín, Rafael Sirera, Marta Usó, Ana Blasco, Sandra Gallach, Santiago Figueroa, Nieves Martínez, Cristina Hernando, Antonio Honguero, Miguel Martorell, Ricardo Guijarro, Rafael Rosell, Eloisa Jantus-Lewintre, Carlos Camps
    Annals of Surgical Oncology.2014; 21(2): 612.     CrossRef
  • VEGF-C in non-small cell lung cancer: Meta-analysis
    Hao Jiang, Wei Shao, Wei Zhao
    Clinica Chimica Acta.2014; 427: 94.     CrossRef
  • High density of peritumoral lymphatic vessels measured by D2-40/podoplanin and LYVE-1 expression in gastric cancer patients: an excellent prognostic indicator or a false friend?
    Julia Rudno-Rudzinska, Wojciech Kielan, Zygmunt Grzebieniak, Piotr Dziegiel, Piotr Donizy, Grzegorz Mazur, Monika Knakiewicz, Ewelina Frejlich, Agnieszka Halon
    Gastric Cancer.2013; 16(4): 513.     CrossRef
  • Multiplexed analysis of angiogenesis and lymphangiogenesis factors predicts outcome for non-small cell lung cancer patients
    Valsamo K. Anagnostou, Dina G. Tiniakos, Marianthi Fotinou, Apostolos Achimastos, Konstantinos N. Syrigos
    Virchows Archiv.2011; 458(3): 331.     CrossRef
  • Prognostic significance of epidermal growth factor receptor and vascular endothelial growth factor receptor in colorectal adenocarcinoma
    JUNG YEON KIM, BYUNG-NOE BAE, JI EUN KWON, HYUN-JUNG KIM, KYEONGMEE PARK
    APMIS.2011; 119(7): 449.     CrossRef
  • Supplementation with a-Tocopherol or ß-Carotene Reduces Serum Concentrations of Vascular Endothelial Growth Factor-D, but Not -A or -C, in Male Smokers
    Alison M. Mondul, Helen C. Rager, William Kopp, Jarmo Virtamo, Demetrius Albanes
    The Journal of Nutrition.2011; 141(11): 2030.     CrossRef
  • Expression Analysis of Angiogenesis-Related Genes in Bulgarian Patients with Early-Stage Non-Small Cell Lung Cancer
    Svetlana Nikolova Metodieva, Dragomira Nikolaeva Nikolova, Radostina Vlaeva Cherneva, Ivanka Istalianova Dimova, Danail Borisov Petrov, Draga Ivanova Toncheva
    Tumori Journal.2011; 97(1): 86.     CrossRef
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Loss of heterozygosity affecting MCC and APC loci in Korean colorectal adenocarcinomas
Won Sang Park, Nam Jin Yoo, Sang Wook Choi, Kyo Young Lee, Suk Young Lee, Jung Yong Lee, Sang Ho Kim, Joo Sung Kim
J Korean Cancer Assoc. 1993;25(5):630-635.
AbstractAbstract PDF
No abstract available.
  • 2,956 View
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Intraglomerular malignant lymphomatosis: a report of a case-
Ki Hwa Yang, Kyo Young Lee, Seok Jin Gang, Byoung Kee Kim, Sang In Shim, Sun Moo Kim
J Korean Cancer Assoc. 1991;23(2):443-450.
AbstractAbstract PDF
No abstract available.
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