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2 "Kwang-Hyun Kim"
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Original Articles
Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer
Tae Ryool Koo, Hong-Gyun Wu, J. Hun Hah, Myung-Whun Sung, Kwang-Hyun Kim, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae-Seog Heo, Charn Il Park
Cancer Res Treat. 2012;44(4):227-234.   Published online December 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.4.227
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study is to analyze treatment outcome of radiotherapy (RT) in patients with stage III-IV tonsil cancer managed by surgery followed by postoperative RT (SRT) and definitive chemoradiotherapy (CRT), and to thereby evaluate the most feasible treatment modality.
MATERIALS AND METHODS
Of 124 patients, 67 underwent CRT, and 57 underwent SRT. We compared survival and complication rates in both groups.
RESULTS
The median follow-up time was 57 months (range, 19 to 255 months) for surviving patients. At five years, locoregional progression-free survival (LRPFS) and overall survival (OS) were 88% and 80%, respectively. No significant difference in LRPFS (p=0.491) and OS (p=0.177) was observed between CRT and SRT. In multivariate analysis, old age and higher T stage showed a significant association with poor LRPFS, PFS, and OS; higher N stage showed an association with poor PFS and a trend of poor LRPFS, while no association with OS was observed; treatment modality (CRT and SRT) showed no association with LRFPS, PFS, and OS. Grade 3 or higher mucositis was observed in 12 patients (21%) in the SRT group, and 25 patients (37%) in the CRT group.
CONCLUSION
Definitive CRT and SRT have similar treatment outcomes for patients with stage III-IV tonsil cancer. Although acute complication rate appears to be higher in the CRT group, it should be noted that not all data on complications were included in this retrospective study. To determine the most feasible treatment modality, not only mucositis and xerostomia, but also emotional aspect and quality of life, should be considered.

Citations

Citations to this article as recorded by  
  • Risk of lymph node metastasis in T1 tonsil squamous cell carcinomas patients according to age stratification at diagnosis
    Yujiao Li, Chaosu Hu
    American Journal of Otolaryngology.2024; 45(6): 104452.     CrossRef
  • Detection of the high-risk factors for synchronous bone metastasis in tonsillar squamous cell carcinoma
    Yujiao Li, Chaosu Hu
    European Archives of Oto-Rhino-Laryngology.2023; 280(10): 4619.     CrossRef
  • The treatment of tonsillar squamous cell carcinoma at Hue Central Hospital
    Phuong Nam Tran
    Journal of Clinical Medicine- Hue Central Hospital.2021;[Epub]     CrossRef
  • Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study
    Sanghyuk Song, Hong-Gyun Wu, Chang Geol Lee, Ki Chang Keum, Mi Sun Kim, Yong Chan Ahn, Dongryul Oh, Hyo Jung Park, Sang-Wook Lee, Geumju Park, Sung Ho Moon, Kwan Ho Cho, Yeon-Sil Kim, Yongkyun Won, Young-Taek Oh, Won-Taek Kim, Jae-Uk Jeong
    BMC Cancer.2017;[Epub]     CrossRef
  • Long-term results of ipsilateral radiotherapy for tonsil cancer
    Tae Ryool Koo, Hong-Gyun Wu
    Radiation Oncology Journal.2013; 31(2): 66.     CrossRef
  • Impact of Postoperative Chemoradiotherapy and Chemoradiotherapy Alone for Esophageal Cancer in North-West Iran
    Seyed Kazem Mirinezhad, Mohammad Hossein Somi, Masoud Shirmohamadi, Farshad Seyednejad, Amir Ghasemi Jangjoo, Morteza Ghojazadeh, Mohammad Mohammadzadeh, Ali Reza Naseri, Behnam Nasiri
    Asian Pacific Journal of Cancer Prevention.2013; 14(6): 3921.     CrossRef
  • 12,463 View
  • 46 Download
  • 6 Crossref
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Retrospective Analysis of the Treatment Results for Patients with Squamous Cell Carcinoma of Tonsil
Ah Ram Chang, Hong-Gyun Wu, Charn Il Park, Kwang-Hyun Kim, Myung-Whun Sung, Dae-Seog Heo
Cancer Res Treat. 2005;37(2):92-97.   Published online April 30, 2005
DOI: https://doi.org/10.4143/crt.2005.37.2.92
AbstractAbstract PDFPubReaderePub
Purpose

There has been no definitive randomized study to identify the optimal therapeutic regimen for treating squamous cell carcinoma of tonsil. The purpose of this study was to retrospectively evaluate the treatment outcome according to various combinations of surgery, radiation therapy and chemotherapy.

Materials and Methods

Fifty-six patients with tonsillar carcinoma, who were treated at Seoul National University Hospital from March 1985 to August 2001, were the subjects of this study. Twenty-one patients received surgery followed by radiation therapy (SRT), 16 patients underwent radiation therapy alone (RT), and 19 patients received neoadjuvant chemotherapy and radiation therapy (CRT). The median radiation dose was 66.6 Gy for the SRT group and 70.2 Gy for the RT and CRT groups. Surgery comprised extended tonsillectomy and modified radical neck dissection of the involved neck. Cisplatin and 5-fluorouracil were used every three weeks for 3 cycles in the SRT group. The median follow-up was 73.2 months.

Results

The distribution of T-stage was 4 cases of T1, 14 cases of T2, 1 case of T3 and 2 cases of T4 staging in the SRT group, 2 cases of T1, 6 cases of T2, 5 cases of T3 and 3 cases of T4 staging in the RT group and 0 cases of T1, 7 cases of T2, 9 cases of T3 and 3 cases of T4 staging in the CRT group. The distribution of N-stage was 5 cases of N0, 2 cases of N1, 13 cases of N2 and 1 case of N3 staging in the SRT group, 6 cases of N0, 5 cases of N1, 5 cases of N2 and 0 cases of N3 staging in the RT group, and 2 cases of N0, and 7 cases of N1, 9 cases of N2 and 1 case of N3 staging in the CRT group. The five-year overall survival rate (OSR) for all patients was 78%. The five-year OSR was 80% for the SRT group, 71% for the RT group, and 80% for the CRT group (p=ns). The five-year disease-free survival rate was 93% for the CRT group and 71% for the RT group (p=0.017). Four patients developed local failure and one patient failed at a regional site in the RT group, and one patient failed at a primary site in the CRT group. The five-year DFS was 84% for patients who had undergone neck dissection and 76% for patients who had not undergone neck dissection (p=ns). Treatment-related complications of grade 3 or 4 occurred in 15 patients, and the incidence of complication was not different between each of the treatment methods.

Conclusion

Although the patients with more advanced T stage were included in the RT and CRT groups, the OSR was not statistically different according to the treatment methods. In the radical radiation therapy group, the addition of neoadjuvant chemotherapy showed an improvement in the disease-free survival. Because of the retrospective nature of our study and the small number of patients, this study cannot draw any definite conclusions, but it suggests that radiation therapy with chemotherapy can be a good alternative option for squamous cell carcinoma of tonsil. Controlled randomized study is necessary to confirm this hypothesis.

Citations

Citations to this article as recorded by  
  • Long-term results of ipsilateral radiotherapy for tonsil cancer
    Tae Ryool Koo, Hong-Gyun Wu
    Radiation Oncology Journal.2013; 31(2): 66.     CrossRef
  • Definitive Radiotherapy versus Postoperative Radiotherapy for Tonsil Cancer
    Tae Ryool Koo, Hong-Gyun Wu, J. Hun Hah, Myung-Whun Sung, Kwang-Hyun Kim, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae-Seog Heo, Charn Il Park
    Cancer Research and Treatment.2012; 44(4): 227.     CrossRef
  • Treatment outcome in the residually positive neck after definitive chemotherapy and irradiation
    Laura M. Dooley, Kevin L. Potts, Liz D. Wilson, Zachary J. Cappello, Jeffrey M. Bumpous
    The Laryngoscope.2011; 121(8): 1656.     CrossRef
  • EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil
    Im Il Na, Hye Jin Kang, Soo Youn Cho, Jae Soo Koh, Jin Kyung Lee, Byeong Cheol Lee, Guk Haeng Lee, Yong Sik Lee, Hyung Jun Yoo, Baek-Yeol Ryoo, Sung Hyun Yang, Yoon Sang Shim
    European Journal of Cancer.2007; 43(3): 520.     CrossRef
  • 10,346 View
  • 47 Download
  • 4 Crossref
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