Cancer Research and Treatment

Original Article

Lung and Thoracic cancer

Cost Utility Analysis of a Pilot Study for the Korean Lung Cancer Screening Project: Juyoung Kim, Bogeum Cho, Seon-Ha Kim, Chang-Min Choi, Yeol Kim, Min-Woo Jo; Cancer Res Treat. 2022;54(3):728-736. Published online September 24, 2021; DOI: https://doi.org/10.4143/crt.2021.480

Abstract PDF Supplementary Material PubReader ePub

Purpose
The aim of this study was to evaluate the cost utility of a pilot study of Korean Lung Cancer Screening Project.
Materials and Methods
We constructed a Markov model consisting of 26 states based on the natural history of lung cancer according to the Surveillance, Epidemiology, and End Results summary stage (localized, regional, distant). In the base case, people aged 55-74 years were under consideration for annual screening. Costs and quality-adjusted life years were simulated to calculate the incremental cost utility ratio. Sensitivity analyses were performed on the uncertainty associated with screening target ages, stage distribution, cost, utility, mortality, screening duration, and discount rate.
Results
The base case (US$25,383 per quality-adjusted life year gained) was cost-effective compared to the scenario of no screening and acceptable considering a willingness-to-pay threshold of US$27,000 per quality-adjusted life years gained. In terms of the target age of screening, the age between 60 and 74 years was the most cost-effective. Lung cancer screening was still cost-effective in the sensitivity analyses on the cost for treatment, utility, mortality, screening duration, and less than 5% discount rates, although the result was sensitive to a rise in positive rates or variation of stage distribution.
Conclusion
Our results showed the cost-effectiveness of annual low-dose computed tomography screening for lung cancer in high-risk populations.

Citations

Citations to this article as recorded by

Quantitative risk factor analysis of prior disease condition and socioeconomic status with the multiple myeloma development: nationwide cohort study
Suein Choi, Eunjin Kim, Jinhee Jung, Sung-Soo Park, Chang-Ki Min, Seunghoon Han
Scientific Reports.2024;[Epub] CrossRef
Survival of lung cancer patients according to screening eligibility using Korean Lung Cancer Registry 2014–2016
Sangwon Lee, Eun Hye Park, Bo Yun Jang, Ye Ji Kang, Kyu-Won Jung, Hyo Soung Cha, Kui Son Choi
Scientific Reports.2024;[Epub] CrossRef
Cost-Effectiveness Analysis of Risk Factor-Based Lung Cancer Screening Program by Low-Dose Computer Tomography in Current Smokers in China
Tiantian Zhang, Xudong Chen, Caichen Li, Xiaoqin Wen, Tengfei Lin, Jiaxing Huang, Jianxing He, Nanshan Zhong, Jie Jiang, Wenhua Liang
Cancers.2023; 15(18): 4445. CrossRef
Applying utility values in cost-effectiveness analyses of lung cancer screening: a review of methods
Preston J. Ngo, Sonya Cressman, Silvia Behar-Harpaz, Deme J. Karikios, Karen Canfell, Marianne F. Weber
Lung Cancer.2022;[Epub] CrossRef
Cost-Effectiveness Analyses of Lung Cancer Screening Using Low-Dose Computed Tomography: A Systematic Review Assessing Strategy Comparison and Risk Stratification
Matthew Fabbro, Kirah Hahn, Olivia Novaes, Mícheál Ó’Grálaigh, James F. O’Mahony
PharmacoEconomics - Open.2022; 6(6): 773. CrossRef

6,733 View
220 Download
3 Web of Science
5 Crossref

First
Prev
Page of 1
Next
Last

Search