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Original Articles
Clinical Value of Ezrin Expression in Primary Osteosarcoma
Chan Kim, Eunah Shin, Soojung Hong, Hong Jae Chon, Hye Ryun Kim, Jung Ryun Ahn, Min Hee Hong, Woo Ick Yang, Jae Kyung Roh, Sun Young Rha
Cancer Res Treat. 2009;41(3):138-144.   Published online September 28, 2009
DOI: https://doi.org/10.4143/crt.2009.41.3.138
AbstractAbstract PDFPubReaderePub
Purpose

Ezrin is a membrane cytoskeletal linker protein and it is known to be associated with metastasis of primary osteosarcoma. The aim of this study is to determine the relationship between an ezrin expression and several key clinical parameters and to elucidate its potential prognostic value for patients with osteosarcoma.

Materials and Methods

Seventy patients with histologically confirmed osteosarcoma and who had no distant metastasis were enrolled between 1995 and 2005 at Yonsei Cancer Center, Severance Hospital, Korea. The clinical parameters were retrospectively reviewed and immunohistochemical staining (IHC) for ezrin was performed using the surgically resected specimens.

Results

Of the 70 tumor specimens, 39 (55.7%) revealed an ezrin expression. More of an osteoblastic histology and an elevated initial ALP level were observed in the ezrin positive patients than in the ezrin negative patients (p=0.008 and 0.001, respectively). The proportion of patients who favorably responded to neoadjuvant chemotherapy (≥90% necrosis) was significantly higher in the group of ezrin positive patients than that in the group of ezrin negative patient (72.2% vs 45.2%, respectively, p=0.024). The ezrin positive patients showed more frequent recurrence than did the ezrin negative patients (64.1% vs 35.5%, respectively, p=0.017). The patients with an ezrin expression also demonstrated poorer survival than did those patients without ezrin expression (5-year EFS: 31.7% vs 61.3%, respectively, p=0.023, 5-year OS: 53.4% vs 71.0%, respectively, p=0.022). When comparing EFS according to both an ezrin expression and chemoresponsiveness, there were trends that the ezrin negative/chemoresponsive group showed the best 5-year EFS (71.4%), followed by the ezrin negative/chemoresistant group (52.9%), the ezrin positive/chemoresponsive group (38.1%) and the ezrin positive/chemoresistant group (13.6%). These trends were statistically significant (p=0.036).

Conclusion

The expression of ezrin by IHC staining was found in 55.7% of the patients with metastasis-free osteosarcoma. Immunoreactivity to ezrin is a negative prognostic factor for survival for the patients suffering with osteosarcoma. Identifying an ezrin expression might offer a valuable piece of information when treating patients with primary osteosarcoma.

Citations

Citations to this article as recorded by  
  • Osteosarcoma-Specific Genes as a Diagnostic Tool and Clinical Predictor of Tumor Progression
    Pattaralawan Sittiju, Parunya Chaiyawat, Dumnoensun Pruksakorn, Jeerawan Klangjorhor, Weerinrada Wongrin, Phichayut Phinyo, Rawikant Kamolphiwong, Areerak Phanphaisarn, Pimpisa Teeyakasem, Prachya Kongtawelert, Peraphan Pothacharoen
    Biology.2022; 11(5): 698.     CrossRef
  • Ezrin gone rogue in cancer progression and metastasis: An enticing therapeutic target
    Ganesh Kumar Barik, Osheen Sahay, Debasish Paul, Manas Kumar Santra
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(4): 188753.     CrossRef
  • Mass Spectrometric-Based Proteomics for Biomarker Discovery in Osteosarcoma: Current Status and Future Direction
    Nutnicha Sirikaew, Dumnoensun Pruksakorn, Parunya Chaiyawat, Somchai Chutipongtanate
    International Journal of Molecular Sciences.2022; 23(17): 9741.     CrossRef
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    Thoracic Cancer.2019; 10(10): 1953.     CrossRef
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  • The Prognostic Role of Ezrin and HER2/neu Expression in Osteosarcoma
    Asmaa G. Abdou, Mona Kandil, Nancy Y. Asaad, Marwa M. Dawoud, Ahmed A. Shahin, Amal F. Abd Eldayem
    Applied Immunohistochemistry & Molecular Morphology.2016; 24(5): 355.     CrossRef
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    Marcella Laschi, Giulia Bernardini, Michela Geminiani, Lorenzo Ghezzi, Loredana Amato, Daniela Braconi, Lia Millucci, Bruno Frediani, Adriano Spreafico, Alessandro Franchi, Domenico Campanacci, Rodolfo Capanna, Annalisa Santucci
    Journal of Cellular Physiology.2015; 230(11): 2718.     CrossRef
  • Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data
    Hai-Yong Ren, Ling-Ling Sun, Heng-Yuan Li, Zhao-Ming Ye
    BioMed Research International.2015; 2015: 1.     CrossRef
  • Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis
    Jianwei Li, Kuanhai Wei, Hailang Yu, Dan Jin, Gang Wang, Bin Yu
    Scientific Reports.2015;[Epub]     CrossRef
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    Izabela Baryła, Ewa Styczeń-Binkowska, Andrzej K Bednarek
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    Deng-Xing Lun, Yong-Cheng Hu, Zhao-Wan Xu, Li-Na Xu, Bin-Wu Wang
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    Shibing Guo, Rui Bai, Wei Zhao, Yuxin Wang, Zhenqun Zhao, Wei Feng
    Tumor Biology.2014; 35(1): 469.     CrossRef
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  • Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis
    Da-Hang Zhao, Jiang Zhu, Wen-Bo Wang, Feng Dong, Qiao Zhang, Hong-Wu Fan, Jing-Zhe Zhang, Yong-Ming Wang
    The Scientific World Journal.2014; 2014: 1.     CrossRef
  • Expression of HMGA1 and Ezrin in laryngeal squamous cell carcinoma
    De-Sheng Wang, Chun-Chen Pan, Hai-Chun Lai, Jian-Min Huang
    Acta Oto-Laryngologica.2013; 133(6): 626.     CrossRef
  • The β5/focal adhesion kinase/glycogen synthase kinase 3β integrin pathway in high-grade osteosarcoma: a protein expression profile predictive of response to neoadjuvant chemotherapy
    Sophie Le Guellec, Elizabeth Cohen-Jonathan Moyal, Thomas Filleron, Marie-Bernadette Delisle, Christine Chevreau, Hervé Rubie, Marie-Pierre Castex, Jerome Sales de Gauzy, Paul Bonnevialle, Anne Gomez-Brouchet
    Human Pathology.2013; 44(10): 2149.     CrossRef
  • Meta-analysis of Associations of the Ezrin Gene with Human Osteosarcoma Response to Chemotherapy and Prognosis
    Zhe Wang, Mao-Lin He, Jin-Min Zhao, Hai-Hui Qing, Yang Wu
    Asian Pacific Journal of Cancer Prevention.2013; 14(5): 2753.     CrossRef
  • The Prognostic Role of Ezrin Immunoexpression in Osteosarcoma: A Meta-Analysis of Published Data
    Hongtao Li, Daliu Min, Hui Zhao, Zhiyu Wang, Weixiang Qi, Shuier Zheng, Lina Tang, Aina He, Yuanjue Sun, Yang Yao, Zan Shen, David Loeb
    PLoS ONE.2013; 8(6): e64513.     CrossRef
  • Effects of siRNA-mediated Cdc2 silencing on MG63 cell proliferation and apoptosis
    XIANG-YONG QUE, YI LI, YU HAN, XIN-ZHI LI
    Molecular Medicine Reports.2013; 7(2): 466.     CrossRef
  • Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
    Ho Won Lee, Eui Han Kim, Mee-Hye Oh
    Korean Journal of Pathology.2012; 46(5): 470.     CrossRef
  • Effects of transplantation sites on tumour growth, pulmonary metastasis and ezrin expression of canine osteosarcoma cell lines in nude mice
    T. Jaroensong, Y. Endo, S.‐J. Lee, A. Kamida, M. Mochizuki, R. Nishimura, N. Sasaki, T. Nakagawa
    Veterinary and Comparative Oncology.2012; 10(4): 274.     CrossRef
  • Prognostic implication of ezrin expression in esophageal squamous cell carcinoma
    Jian‐Jun Xie, Li‐Yan Xu, Zhi‐Yong Wu, Qing Zhao, Xiu‐E Xu, Jian‐Yi Wu, Qiao Huang, En‐Min Li
    Journal of Surgical Oncology.2011; 104(5): 538.     CrossRef
  • Identification of the VIL2 enhancer in human embryonic kidney cells
    Shu‐Ying Gao, Yan‐Peng Dai, Xia Long, Fang‐Ting Zhang, Jie Yu
    Cell Biology International.2011; 35(10): 967.     CrossRef
  • Rôle du pathologiste dans la prise en charge des tumeurs osseuses primitives malignes : ostéosarcomes et tumeurs de la famille Ewing après traitement néoadjuvant
    Anne Gomez-Brouchet, Corinne Bouvier, Anne-Valérie Decouvelaere, Frédérique Larousserie, Sébastien Aubert, Xavier Leroy, Jean-Marc Guinebretière, Aurore Coulomb, Elisabeth Cassagnau, Anne de Muret, Virginie Audard, Béatrice Marie, Gonzague de Pinieux
    Annales de Pathologie.2011; 31(6): 455.     CrossRef
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    S. Gao, Y. Dai, M. Yin, J. Ye, G. Li, J. Yu
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  • YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma
    Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini, Claudio Napoli
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    Shuhui Zheng, Jinghe Huang, Kewen Zhou, Chengxi Zhang, Qiuling Xiang, Zhi Tan, Tinghuai Wang, Xiaodong Fu, Jean-Marc Vanacker
    PLoS ONE.2011; 6(7): e22439.     CrossRef
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    Ana Carneiro, Pär-Ola Bendahl, Måns Åkerman, Henryk A Domanski, Anders Rydholm, Jacob Engellau, Mef Nilbert
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  • Immunoexpression of Ezrin and CD44 in Patients With Osteosarcoma
    Erica Boldrini, Stela Verzinhasse Peres, Sandra Morini, Beatriz de Camargo
    Journal of Pediatric Hematology/Oncology.2010; 32(6): e213.     CrossRef
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    Gayathri Thevi Selvarajah, Jolle Kirpensteijn
    The Veterinary Journal.2010; 185(1): 28.     CrossRef
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  • 33 Crossref
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Prognosis of pN3 Stage Gastric Cancer
Jung Ryun Ahn, Minkyu Jung, Chan Kim, Min Hee Hong, Hong Jae Chon, Hye Ryun Kim, Hei-Cheul Jeung, Woo Jin Hyung, Sung Sook Lee, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha
Cancer Res Treat. 2009;41(2):73-79.   Published online June 30, 2009
DOI: https://doi.org/10.4143/crt.2009.41.2.73
AbstractAbstract PDFPubReaderePub
Purpose

The aim of this study was to determine the prognosis of pN3 stage gastric cancer patients after they have undergone curative resection, and we also wanted to identify the prognostic factors according to the clinico-pathologic features.

Materials and Methods

Between January 2000 and December 2004, we retrospectively reviewed the medical records of the patients with histologically confirmed pN3 stage gastric cancer. They underwent both gastrectomy and lymphadenectomy with a curative aim. We categorized the pN3 stage patients into 2 groups; one with pN3 only (pN3M0) and the other with pN3 combined with M1 stage (pN3M1) that included peritoneal seeding, hepatic metastasis or para-aortic LN metastasis.

Results

Out of 467 patients with stage IV gastric adenocarcinoma who received surgery, 260 patients underwent curative resection and they were pathologically staged as N3. Among these 260 patients, 78 patients were classified as the pN3/M1 stage. For all the patients, the median follow-up period was 19 months (range: 1~108 months) and the median overall survival time was 16.2 months (95% CI, 14.1~18.3%). The 5-year survival rate of the pN3/M0 group was significantly higher than that of the pN3/M1 group (12.6% vs. 2.6%, respectively, p<0.0001). The identified predictor for a worse prognosis was an advanced T4 stage (HR: 3.38, 95% CI, 1.4~8.3, p=0.008) for the pN3 patients.

Conclusion

The survival for the pN3 gastric cancer patients after curative gastrectomy was significantly longer in the pN3/M0 group as compared to that of the pN3/M1 group. An advanced T stage was a predictor for a poor prognosis for the pN3 patients. Therefore, diverse treatment strategies for these heterogeneous pN3 gastric cancer patients are needed for improving their survival.

Citations

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Treatment Outcomes of Sunitinib Treatment in Advanced Renal Cell Carcinoma Patients: A Single Cancer Center Experience in Korea
Min Hee Hong, Hyo Song Kim, Chan Kim, Jung Ryun Ahn, Hong Jae Chon, Sang-Joon Shin, Joong-Bae Ahn, Hyun Cheol Chung, Sun Young Rha
Cancer Res Treat. 2009;41(2):67-72.   Published online June 30, 2009
DOI: https://doi.org/10.4143/crt.2009.41.2.67
AbstractAbstract PDFPubReaderePub
Purpose

The retrospective study was performed to assess the efficacy and toxicity profiles of sunitinib in Korean patients with metastatic renal cell carcinoma (RCC).

Materials and Methods

Between January 2005 and December 2008, 76 Korean patients with recurrent/metastatic RCC who received sunitinib were retrospectively reviewed. The primary end point was progression-free survival and the secondary end points were overall survival and response rate. We also assessed the toxicities associated with sunitinib treatment.

Results

Of the 76 patients, 69 (90.1%) were diagnosed with clear cell RCC. The median progression-free survival and overall survival were 7.2 and 22.8 months, respectively in overall patients. Sixty-two patients (81.6%) received 50 mg 4 week and 2 week off schedule, and 14 patients (18.4%) received 37.5 mg daily on a daily continuous schedule. The objective response rate and disease control rate were 27.6% and 84.2%, respectively. A dose reduction or reduction in dose due to adverse events occurred in 76% of the patients, whereas 11% of the patients had discontinued treatment. Other common laboratory abnormalities were increased serum creatinine (75.6%), elevated alanine aminotransferase (71.0%), neutropenia (61.8%), anemia (69.7%), and increased aspartate aminotrasferase (53.3%). Grade 3/4 toxicities occurred as follows: thrombocytopenia (38.2%), fatigue (10.5%), stomatitis (10.5%), and hand-foot syndrome (9.2%).

Conclusion

Our results indicate that sunitinib treatment is effective and tolerable for ecurrent/metastatic RCC patients in Korea. Further studies with prognostic or biochemical factors are needed to clarify the different toxicity profiles of this study.

Citations

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