Cancer Research and Treatment

Original Articles

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study: Kyeong A So, Mi Jung Kim, Ki-Heon Lee, In-Ho Lee, Mi Kyung Kim, Yoo Kyung Lee, Chang-Sun Hwang, Mi Seon Jeong, Mee-Kyung Kee, Chun Kang, Chi Heum Cho, Seok Mo Kim, Sung Ran Hong, Ki Tae Kim, Won-Chul Lee, Jong Sup Park, Tae Jin Kim; Cancer Res Treat. 2016;48(4):1313-1320. Published online March 9, 2016; DOI: https://doi.org/10.4143/crt.2016.013

Purpose
The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).
Materials and Methods
The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months.
Results
A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
Conclusion
HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

Citations

Citations to this article as recorded by

Women 50 Years and Older With Negative Pap Test and Positive Human Papillomavirus Test for Genotypes Other Than 16 and 18—Follow-up Outcomes
Farah S. Baban, Michael R. Henry, Margaret E. Long, Meredith A. VandeHaar, Grant M. Spears, Sarah M. Jenkins, Diva R. Salomao
Journal of Lower Genital Tract Disease.2024; 28(1): 43. CrossRef
Cervical intraepithelial neoplasia in non-16/18 high-risk human papilloma virus positive/cytology negative women: An alternative approach in poor resource areas
Fariba Yarandi, Elham Shirali, Elham Feizabad, Sara Ramhormoziyan, Soheila Sarmadi, Maryam SadrAmeli, Elham Arshadi
Taiwanese Journal of Obstetrics and Gynecology.2023; 62(2): 299. CrossRef
Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Journal of Cancer Research and Clinical Oncology.2023; 149(10): 8077. CrossRef
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef
Association strength of E6 to E6AP/p53 complex correlates with HPV‐mediated oncogenesis risk
Matheus Vitor Ferreira Ferraz, Isabelle Freire Tabosa Viana, Danilo Fernandes Coêlho, Carlos Henrique Bezerra da Cruz, Maíra de Arruda Lima, Madson Allan de Luna Aragão, Roberto Dias Lins
Biopolymers.2022;[Epub] CrossRef
Diagnostic performance of immediate colposcopy among women with high‐risk human papillomavirus (HPV) other than HPV 16/18 and normal cytology
Serdar Aydın, Hande Nur Öncü, Dilek Sema Arıcı
Journal of Obstetrics and Gynaecology Research.2021; 47(2): 720. CrossRef
Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
Rachelle P. Mendoza, Tahmineh Haidary, Elmer Gabutan, Ying Yin Zhou, Zaheer Bukhari, Courtney Connelly, Wen-Ching Lee, Yi-Chun Lee, Raj Wadgaonkar, Raag Agrawal, M. A. Haseeb, Raavi Gupta
Scientific Reports.2021;[Epub] CrossRef
Distribution of HPV genotypes among women with abnormal cytology results in Alberta, Canada
Sabrina S Plitt, Ryan Kichuk, Sheena Geier, Trenton Smith, Felicia Roy, Alberto Severini, Carmen L Charlton
Journal of the Association of Medical Microbiology and Infectious Disease Canada.2021; 6(2): 94. CrossRef
The Clinical Significance and Utility of HPV-DNA Testing in Korean Women with Atypical Glandular Cells in Cervical Pap Tests: An Analysis of 311 Cases at a Single Institution
Tae-Kyu Jang, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Cancer Investigation.2021; 39(10): 885. CrossRef
Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Jaehyun Seong, Sangmi Ryou, JeongGyu Lee, Myeongsu Yoo, Sooyoung Hur, Byeong-Sun Choi
Virology Journal.2021;[Epub] CrossRef
Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China
Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui, Xingsheng Yang
Infectious Agents and Cancer.2020;[Epub] CrossRef
Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women
Marco A Escarcega-Tame, Marcela López-Hurtado, Marcos R Escobedo-Guerra, Elba Reyes-Maldonado, Graciela Castro-Escarpulli, Fernando M Guerra-Infante
International Journal of STD & AIDS.2020; 31(13): 1255. CrossRef
Artificial intelligence estimates the impact of human papillomavirus types in influencing the risk of cervical dysplasia recurrence: progress toward a more personalized approach
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
European Journal of Cancer Prevention.2019; 28(2): 81. CrossRef
Human papillomavirus genotype-specific risk in cervical carcinogenesis
Kyeong A So, In Ho Lee, Ki Heon Lee, Sung Ran Hong, Young Jun Kim, Hyun Hee Seo, Tae Jin Kim
Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Comparison of the PANArray HPV Genotyping Chip Test with the Cobas 4800 HPV and Hybrid Capture 2 Tests for Detection of HPV in ASCUS Women
Eun Young Ki, Yoon Kyung Lee, Ahwon Lee, Jong Sup Park
Yonsei Medical Journal.2018; 59(5): 662. CrossRef
Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
Infectious Agents and Cancer.2017;[Epub] CrossRef

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A Clinicopathological Review of Pulmonary Metastasis from Uterine Cervical Cancer: Eun Young Ki, Keun Ho Lee, Jong Sup Park, Soo Young Hur; Cancer Res Treat. 2016;48(1):266-272. Published online February 23, 2015; DOI: https://doi.org/10.4143/crt.2014.206

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Purpose
The purpose of this study was to investigate the clinicopathological features of pulmonary metastasis from cervical cancer. Materials and Methods We reviewed the medical records of 56 patients with cervical cancer who developed pulmonary metastasis after radical hysterectomy, postoperative concurrent chemoradiation or systemic chemotherapy between January 1990 and March 2014.
Results
Fifty-six patients were diagnosed with pulmonary metastasis from cervical cancer. The prevalence of pulmonary metastasis was 3.6%. The mean event-free duration was 12 months. Twelve patients underwent surgical removal of metastatic lesions. The overall survival (OS) of patients with ≤ 3 metastatic lung lesions was 40.7 months, longer than those with > 4 lesions (25 months, p=0.034). The OS of patients who underwent surgical resection was 53.8 months, longer than that of those who did not (p=0.006). In addition, the OS of patients with adjuvant platinum-based chemotherapy was 32.6 months (p=0.027). Conclusion In this study, we found that the number of metastatic nodules, surgical resection, and postoperative platinum-based chemotherapy can influence clinical outcome. Further studies on prognostic factors and successful treatment modalities are warranted.

Citations

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Construction and validation of an innovative prognostic nomogram for overall survival in cervical cancer patients with lung metastasis: an analysis utilizing the SEER database
Linlin Chang, Kangkang Zhao
Frontiers in Oncology.2024;[Epub] CrossRef
Cervical cancer: Challenges and prevention strategies: A narrative review
Abate Wondesen Tsige, Dessale Abate Beyene
Health Science Reports.2024;[Epub] CrossRef
Limited Additional Value of a Chest CT in Whole-Body Staging with PET-MRI: A Retrospective Cohort Study
Tineke van de Weijer, Wilhelmina L. van der Meer, Rik P. M. Moonen, Thiemo J. A. van Nijnatten, Hester A. Gietema, Cristina Mitea, Jochem A. J. van der Pol, Joachim E. Wildberger, Felix M. Mottaghy
Cancers.2024; 16(12): 2265. CrossRef
Systematic approach to identify therapeutic targets and functional pathways for the cervical cancer
Md. Tanvir Hasan, Md. Rakibul Islam, Md. Rezwan Islam, Baraa Riyadh Altahan, Kawsar Ahmed, Francis M. Bui, Sami Azam, Mohammad Ali Moni
Journal of Genetic Engineering and Biotechnology.2023; 21(1): 10. CrossRef
Multidimensional outlook on the pathophysiology of cervical cancer invasion and metastasis
Neena George, Poonam Bhandari, Padival Shruptha, Pradyumna Jayaram, Sima Chaudhari, Kapaettu Satyamoorthy
Molecular and Cellular Biochemistry.2023; 478(11): 2581. CrossRef
Tetramethylpyrazine inhibits the proliferation, invasiveness and migration of cervical cancer C33A cells by retarding the Hedgehog signaling pathway
Jing Ren, Jiping Cai, Changfeng Wang
Oncology Letters.2022;[Epub] CrossRef
A molecular approach integrating genomic and DNA methylation profiling for tissue of origin identification in lung-specific cancer of unknown primary
Kaiyan Chen, Fanrong Zhang, Xiaoqing Yu, Zhiyu Huang, Lei Gong, Yanjun Xu, Hui Li, Sizhe Yu, Yun Fan
Journal of Translational Medicine.2022;[Epub] CrossRef
Whole-Exome Sequencing Could Distinguish Primary Pulmonary Squamous Cell Carcinoma From Lung Metastases in Individuals With Cervical Squamous Cell Carcinoma
Lihong Li, Qianqian Song, Dandan Cao, Yuchen Jiao, Guangwen Yuan, Yan Song
Pathology and Oncology Research.2022;[Epub] CrossRef
Cervical Cancer Imaging Features Associated With ADRB1 as a Risk Factor for Cerebral Neurovascular Metastases
Xingju Zheng, Shilin Xu, JiaYing Wu
Frontiers in Neurology.2022;[Epub] CrossRef
Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract
Jennifer Pors, Sheila Segura, Derek S. Chiu, Noorah Almadani, Hezhen Ren, Daniel J. Fix, Brooke E. Howitt, David Kolin, W. Glenn McCluggage, Jelena Mirkovic, Blake Gilks, Kay J. Park, Lynn Hoang
American Journal of Surgical Pathology.2021; 45(4): 498. CrossRef
Analysis of related risk factors of lung metastasis after laparoscopic radical hysterectomy of cervical cancer
Liu Henglian, Wang Jiajun, Wang Caixia, Lu Gang, Xia Min
Medicine.2021; 100(18): e24480. CrossRef
ACR Appropriateness Criteria® Staging and Follow-up of Primary Vaginal Cancer
Aoife Kilcoyne, Ravi V. Gottumukkala, Stella K. Kang, Esma A. Akin, Carlin Hauck, Nicole M. Hindman, Chenchan Huang, Namita Khanna, Rajmohan Paspulati, Gaiane M. Rauch, Tamer Said, Atul B. Shinagare, Erica B. Stein, Aradhana M. Venkatesan, Katherine E. Ma
Journal of the American College of Radiology.2021; 18(11): S442. CrossRef
Risk Assessment of Pulmonary Metastasis for Cervical Cancer Patients by Ensemble Learning Models: A Large Population Based Real-World Study
Menglin Zhu, Bo Wang, Tiejun Wang, Yilin Chen, Du He
International Journal of General Medicine.2021; Volume 14: 8713. CrossRef
The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study
Yi-Hsuan Hsiao, Pei-Ni Chen, Min-Chien Hsin, Po-Hui Wang, Jing-Yang Huang, Shun-Fa Yang
Aging.2021; 13(24): 25846. CrossRef
Defining the role of high-dose radiation in oligometastatic & oligorecurrent cervical cancer
Akshay Mangaj, Supriya Chopra, Remi A. Nout
Indian Journal of Medical Research.2021; 154(2): 303. CrossRef
Detection of Recurrent Cervical Cancer and Prediction of Its Patient Survival with Serum Squamous-Cell Carcinoma-Antigen and 2-[18F] Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography/Computed Tomography
Nan-Jing Peng, Chin Hu, Yu-Li Chiu, Chang-Ching Yu, Chia-Jung Li, Jim Jinn-Chyuan Sheu, An-Jen Chiang
Diagnostics.2020; 10(9): 657. CrossRef
Pulmonary microvascular metastases in cervical carcinoma
P Vaideeswar, Y Aswani, S Damani, S Singaravel
Journal of Postgraduate Medicine.2020; 66(3): 155. CrossRef
Outcome and prognostic factors in cervical cancer patients treated with surgery and concurrent chemoradiotherapy: a retrospective study
Yan-Mei Liu, Ling-Qin Ni, Sai-Sai Wang, Qian-Ling Lv, Wei-Jun Chen, Shen-Peng Ying
World Journal of Surgical Oncology.2018;[Epub] CrossRef
Advances in diagnosis and treatment of metastatic cervical cancer
Haoran Li, Xiaohua Wu, Xi Cheng
Journal of Gynecologic Oncology.2016;[Epub] CrossRef
Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with locally advanced cervical cancer treated with radiation or chemoradiation
Jinju Oh, Hyun Joo Lee, Tae Sung Lee, Ju Hyun Kim, Suk Bong Koh, Youn Seok Choi
Obstetrics & Gynecology Science.2016; 59(4): 269. CrossRef

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High-Dose-Rate Brachytherapy for the Treatment of Vaginal Intraepithelial Neoplasia: Jin Ho Song, Joo Hwan Lee, Jong Hoon Lee, Jong Sup Park, Sook Hee Hong, Hong Seok Jang, Yeon Sil Kim, Byung Ock Choi, Sei Chul Yoon; Cancer Res Treat. 2014;46(1):74-80. Published online January 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.1.74

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PURPOSE
Vaginal intraepithelial neoplasia (VAIN), a rare premalignant condition, is difficult to eradicate. We assess the effectiveness of high-dose rate intracavitary brachytherapy (HDR-ICR) in patients with VAIN or carcinoma in situ (CIS) of the vagina after hysterectomy.
MATERIALS AND METHODS
We reviewed 34 patients treated for posthysterectomy VAIN or CIS of the vagina by brachytherapy as the sole treatment. All patients underwent a coloposcopic-directed punch biopsy or had abnormal cytology, at least 3 consecutive times. All patients were treated with a vaginal cylinder applicator. The total radiation dose was mainly 40 Gy in 8 fractions during the periods of 4 weeks at a prescription point of the median 0.2 cm (range, 0 to 0.5 cm) depth from the surface of the vaginal mucosa.
RESULTS
Acute toxicity was minimal. Seven patients had grade 1/2 acute urinary and rectal complications. There were 15 cases of late toxicity, predominantly vaginal mucosal reaction in 12 patients. Of these patients, two patients suffered from grade 3 vaginal stricture and dyspareunia continuously. After a median follow-up time of 48 months (range, 4 to 122 months), there were 2 recurrences and 2 persistent diseases, in which a second-line therapy was needed. The success rate was 88.2%. The average prescription point in failure patients was 1.1 mm from the surface of the vagina compared to an average of 2.6 mm in non-recurrent patients (p=0.097).
CONCLUSION
HDR-ICR is an effective treatment method in VAIN patients. In spite of high cure rates, we should consider issues regarding vaginal toxicity and radiation techniques to reduce the occurrence of failure and toxicity.

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Yana Liu, Meng Mao, Jing Bai, Mingbo Cai, Qian Wang, Hanlin Fu, Mengling Zhao, Chunfang Wang, Lulu Si, Ruixia Guo
BMC Women's Health.2024;[Epub] CrossRef
Advances in the Treatment of High-Grade Stump Vaginal Intraepithelial Neoplasia after Total Hysterectomy
俐君刘
Advances in Clinical Medicine.2024; 14(04): 1555. CrossRef
Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies
Jiahui Wei, Yumei Wu
Archives of Gynecology and Obstetrics.2024; 310(1): 1. CrossRef
Non-Excisional therapeutic modalities in vaginal intraepithelial neoplasia
Gonçalo Freitas, Antónia Costa
European Journal of Obstetrics & Gynecology and Reproductive Biology.2023; 284: 175. CrossRef
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) Consensus State
Vesna Kesic, Xavier Carcopino, Mario Preti, Pedro Vieira-Baptista, Federica Bevilacqua, Jacob Bornstein, Cyrus Chargari, Maggie Cruickshank, Emre Erzeneoglu, Niccolò Gallio, Murat Gultekin, Debra Heller, Elmar Joura, Maria Kyrgiou, Tatjana Madić, François
Journal of Lower Genital Tract Disease.2023; 27(2): 131. CrossRef
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus state
Vesna Kesic, Xavier Carcopino, Mario Preti, Pedro Vieira-Baptista, Federica Bevilacqua, Jacob Bornstein, Cyrus Chargari, Maggie Cruickshank, Emre Erzeneoglu, Niccolò Gallio, Murat Gultekin, Debra Heller, Elmar Joura, Maria Kyrgiou, Tatjana Madić, François
International Journal of Gynecological Cancer.2023; 33(4): 446. CrossRef
Analysis of related factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia
Y.Y. Zhang, R. Xia, D. Chen, X. Zhang
Clinical and Translational Oncology.2022; 24(5): 902. CrossRef
Sexual Health Dysfunction After Radiotherapy for Gynecological Cancer: Role of Physical Rehabilitation Including Pelvic Floor Muscle Training
Amelia Barcellini, Mattia Dominoni, Francesca Dal Mas, Helena Biancuzzi, Sara Carla Venturini, Barbara Gardella, Ester Orlandi, Kari Bø
Frontiers in Medicine.2022;[Epub] CrossRef
Clinical outcomes of laser vaporization for vaginal intraepithelial neoplasia – A 20-year retrospective review
Mung Yuen He, Ellen Lok-man Yu, Sze Ki Hui, Yau Lung Fred Kung
European Journal of Obstetrics & Gynecology and Reproductive Biology.2022; 277: 101. CrossRef
Detection of high‐risk human papillomavirus infection and treatment of high‐grade vaginal intraepithelial neoplasia: A single‐institution study
Hyun‐Woong Cho, Jin Hwa Hong, Jae Kwan Lee
International Journal of Gynecology & Obstetrics.2021; 154(2): 227. CrossRef
UK national survey of the management of vaginal intraepithelial neoplasia
Mahalakshmi Gurumurthy, Simon Leeson, John Tidy, Margaret E. Cruickshank
Journal of Obstetrics and Gynaecology.2020; 40(5): 694. CrossRef
Vaginal carcinoma after cervical dysplasia
Mikel Gorostidi, Arantza Lekuona, Arantxa Juaristi, Glauco Baiocchi
International Journal of Gynecological Cancer.2020; 30(2): 265. CrossRef
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Argirios Rountis, Vasilios Pergialiotis, Paraskevi Tsetsa, Alexandros Rodolakis, Dimitrios Haidopoulos
International Journal of Clinical Practice.2020;[Epub] CrossRef
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International Journal of Toxicology.2018; 37(5): 373. CrossRef
Total vaginectomy for refractory vaginal intraepithelial neoplasia III of the vaginal vault
Ju Hyun Youn, Min Ah Lee, Woong Ju, Seoung Cheol Kim, Yun Hwan Kim
Obstetrics & Gynecology Science.2016; 59(1): 71. CrossRef
Brachytherapy for vaginal intraepithelial neoplasia
Agnieszka Zolciak-Siwinska, Ewelina Gruszczynska, Joanna Jonska-Gmyrek, Anna Kulik, Wojciech Michalski
European Journal of Obstetrics & Gynecology and Reproductive Biology.2015; 194: 73. CrossRef

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The Increasing Frequency of Cervical Cancer in Korean Women under 35: Chan Hee Han, Hyun Jung Cho, Sung Jong Lee, Jeong Hoon Bae, Seog Nyen Bae, Sung Eun Namkoong, Jong Sup Park; Cancer Res Treat. 2008;40(1):1-5. Published online March 31, 2008; DOI: https://doi.org/10.4143/crt.2008.40.1.1

Abstract PDF PubReader ePub

Purpose

The goal of this study was to determine the clinical and epidemiological trends of cervical cancer in young Korean women. Social behavior including sexual habits has changed in Korean women, with sexual activity commencing at a younger age. These changes are likely to influence certain risk factors of cervical cancer, resulting in changing trends in the occurrence of the disease.

Materials and Methods

The incidence of cervical cancer in women less than 35 years-old between January 1990 and December 2006 was analyzed, and available medical records from January 1996 to December 2006 were reviewed. The clinical, pathological and epidemiologic characteristics and changing trends among these young patients were analyzed.

Results

Over the last two decades, the incidence of young (< 35 years) cervical cancer patients increased, more patients had an aggressive form of the disease, and there was a higher rate of women with more advanced education. Human papillomavirus (HPV) infection was detected in 94.0% of the women (63/67) tested. HPV 16 (82.5%) and HPV 18 (12.7%) were the two most common viral infections detected throughout the study period.

Conclusions

The changing trends and risk factors identified suggest a need for more active education of young women about cervical cancer prevention strategies. In addition, young women are strongly recommended to undergo a regular screening test and HPV vaccination.

Citations

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Prevalence and Treatment of Vulvar Cancer From 2014−2018: A Nationwide Population-Based Study in Korea
Yung-Taek Ouh, Dongwoo Kang, Hoseob Kim, Jae Kwan Lee, Jin Hwa Hong
Journal of Korean Medical Science.2022;[Epub] CrossRef
Successful Treatment of Synchronous Double Lung Primary Malignancies and Colon Cancer
Hosam A Alghanmi
Cureus.2022;[Epub] CrossRef
WITHDRAWN: Polymerase chain reaction technique for molecular detection of HPV16 infections among women with cervical cancer in Dhi-Qar Province
Abduladheem Turki Jalil, Ali Hussein Demin Al-Khafaji, Aleksandr Karevskiy, Saja Hussain Dilfy, Zaman K. Hanan
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Current Status of Human Papillomavirus Infection and Introduction of Vaccination to the National Immunization Program in Korea: an Overview
Min-A Kim, Gwan Hee Han, Jae-Hoon Kim, Kyung Seo
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Management for locally advanced cervical cancer: new trends and controversial issues
Oyeon Cho, Mison Chun
Radiation Oncology Journal.2018; 36(4): 254. CrossRef
Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
Cancer Research and Treatment.2017; 49(2): 526. CrossRef
Factors associated with participation in cervical cancer screening among young Koreans: a nationwide cross-sectional study
Ha Kyun Chang, Jun-Pyo Myong, Seung Won Byun, Sung-Jong Lee, Yong Seok Lee, Hae-Nam Lee, Keun Ho Lee, Dong Choon Park, Chan Joo Kim, Soo Young Hur, Jong Sup Park, Tae Chul Park
BMJ Open.2017; 7(4): e013868. CrossRef
Molecular Detection and Typing of Human Papillomaviruses in Paraffin-Embedded Cervical Cancer and Pre-Cancer Tissue Specimens
Pezhman Mahmoodi, Hossein Motamedi, Masoud Reza Seyfi Abad Shapouri, Mahjabin Bahrami Shehni, Mohammad Kargar
Iranian Journal of Cancer Prevention.2016;[Epub] CrossRef
Cervical cancer in north-eastern Libya: 2000–2008
F. Ben Khaial, Z. Bodalal, A. Elramli, F. Elkhwsky, A. Eltaguri, R. Bendardaf
Journal of Obstetrics and Gynaecology.2014; 34(6): 523. CrossRef
Current status of the National Cancer Screening Program for cervical cancer in Korea, 2009
Young Hwa Lee, Kui Son Choi, Hoo-Yeon Lee, Jae Kwan Jun
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Laparoscopic versus open radical hysterectomy in early-stage cervical cancer: long-term survival outcomes in a matched cohort study
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Annals of Oncology.2012; 23(4): 903. CrossRef
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Mi-La Kim, Ho-Suap Hahn, Kyung-Taek Lim, Ki-Heon Lee, Hy-Sook Kim, Sung-Ran Hong, Tae-Jin Kim
Journal of Gynecologic Oncology.2011; 22(1): 25. CrossRef
Human papillomavirus 16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy Korean women
Seung Cheol Kim, Yong Sang Song, Young-Tae Kim, Young Tak Kim, Ki-Sung Ryu, Bhavyashree Gunapalaiah, Dan Bi, Hans L Bock, Jong-Sup Park
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Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer
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Gynecologic Oncology.2011; 120(2): 270. CrossRef

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Polymorphisms of p53, p21 and IRF-1 and Cervical Cancer Susceptibility in Korean Women: Sung Jong Lee, Sung Eun Namkoong, Won Chul Lee, Jae Woong Sul, Sun Ha Jee, Youn Kyoung You, Jong Eun Lee, Jong Sup Park; Cancer Res Treat. 2002;34(5):357-364. Published online October 31, 2002; DOI: https://doi.org/10.4143/crt.2002.34.5.357

Abstract PDF

PURPOSE
The aim of this study was to identify gene- gene and gene-environmental factor on cervical carcinogenesis in Korean women.
MATERIALS AND METHODS
We evaluated 185 women patients who had cervical cancer with 345 normal control healthy women. The single nucleotide polymorphisms (SNPs) of the p53 codon 72, the p21 codon 31 and the IRF-1 intron 6 were evaluated from extracted DNA of peripheral blood with an automatic DNA sequencer. The difference of each SNP, gene-gene and gene-environmental interaction between normal controls and patients, were evaluated in an adjusted environmental background.
RESULTS
With regard to environmental factors, the cervical cancer increased in the women with a lower level of education, a younger age at first sexual intercourse and with the increased number of children borne. The women who had p53 (Arg/Arg), IRF-1 (T/T) and an education of less than 6 years showed a 14.7 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and an education of more than 15 years. The women who had p53 (Arg/Arg), p21 (Ser/Ser) and more than 3 children showed a 6.4 fold increased risk of cervical cancer than those women who had p53 (~Pro), p21 (~Arg) and had borne no child. The women who had p53 (Arg/Arg), IRF-1 (T/T) and had experience of first sexual intercourse before the age of 22-years showed a 5.5 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and had experience of first sexual intercourse after the age of 26-years.
CONCLUSION
We found that the level of education, the age at first intercourse, and the number of children borne, were independent risk factors in cervical carcinogenesis. The specific combination of p53, p21 and IRF-1 gene-gene and gene-environmental interactions were significantly noted in the cervical carcinogenesis of Korean women.

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Distinctive cell cycle regulatory protein profiles by adenovirus delivery of p53 in human papillomavirus-associated cancer cells
H.-S. JIN, S.-M. BAE, Y.-W. KIM, J.-M. LEE, S.-E. NAMKOONG, B.-D. HAN, Y.-J. LEE, C.-K. KIM, H.-J. CHUN, W.-S. AHN
International Journal of Gynecological Cancer.2006; 16(2): 698. CrossRef
Cell Cycle Regulatory Protein Expression Profiles by Adenovirus p53 Infection in Human Papilloma Virus-associated Cervical Cancer Cells
Yong-Seok Lee, Su-Mi Bae, Sun-Young Kwak, Dong-Chun Park, Yong-Wook Kim, Soo-Young Hur, Eun-Kyung Park, Byoung-Don Han, Young-Joo Lee, Chong-Kook Kim, Do Kang Kim, Woong-Shick Ahn
Cancer Research and Treatment.2006; 38(3): 168. CrossRef
Cellular process classification of human papillomavirus-16-positive SiHa cervical carcinoma cell using Gene Ontology
W. S. Ahn, M.-J. Seo, S. M. Bae, J. M. Lee, S. E. Namkoong, C. K. Kim, Y.-W. Kim
International Journal of Gynecological Cancer.2005; 15(1): 94. CrossRef

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Growth Suppression of Ovarian Cancer Cells by Interferon-gama: Jong Sup Park, Eun Joo Kim, Tae Chul Park, Eun Jung Kim, Jin Kim, Joon Mo Lee, Sung Eun Namkoong, Soo Jong Um; Cancer Res Treat. 2001;33(3):236-242. Published online June 30, 2001; DOI: https://doi.org/10.4143/crt.2001.33.3.236

Abstract PDF

PURPOSE
Growth regulation of cancer cells very frequently involves tumor suppressor gene p53, Rb and cell cycle regulator, however the molecular biologic mechanisms of growth regulation in ovarian carcinoma cells are not fully defined. To assess the mechanism of growth suppression, we treated IFN-gama in ovarian carcinoma cells.
MATERIALS AND METHODS
Growth suppression by treatment of IFN-gama was determined by cell proliferation assay in ovarian carcinoma cell lines. Apoptosis was determined by DNA fragmentation assay and electron microscopy. Molecular mechanism of the apoptosis in ovarian carcinoma cell by IFN-gama was further analyzed by the western blot.
RESULTS
We found that IFN-gama had remarkable growth- suppressive effects in PA-1 and A2774 ovarian carcinoma cells in a time-dependent manner. Apoptosis was observed in PA-1 and A2774 cell following treatment of IFN- gama by DNA fragmentation assay and EM. The expression of IRF-1 protein from A2774 and PA-1 cell extracts was elevated by increasing the concentration of IFN-gama. IFN-gama caused an increased expression of the important apoptosis-related gene, ICE (interleukin-1beta-converting enzyme) protein in A2774 and PA-1.
CONCLUSION
The coordinate induction of IRF-1 and ICE by IFN-gama in ovarian carcinoma cells suggests a functional relationship between these proteins in programmed cell death. The significance of this study is the molecular biologic background of IFN-gama considered as an alternative treatment trial of ovarian cancers.

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Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions
Hee-Don Chae, Jeanho Yun, Yung-Jue Bang, Deug Y Shin
Oncogene.2004; 23(23): 4084. CrossRef
Cdk2-dependent Phosphorylation of the NF-Y Transcription Factor and Its Involvement in the p53-p21 Signaling Pathway
Jeanho Yun, Hee-Don Chae, Tae-Saeng Choi, Eun-Hee Kim, Yung-Jue Bang, Jongkyeong Chung, Kyeong-Sook Choi, Roberto Mantovani, Deug Y. Shin
Journal of Biological Chemistry.2003; 278(38): 36966. CrossRef

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Growth Regulation of Ovarian Cancer Cells through the Inactivation of AP-1 by Retinoid Derivatives: Young Me Koh, Jong Sup Park, Sung Eun Namkoong, So Young Lee, Soo A Kim, Kyong Ja Hong, Soo Jong Um; J Korean Cancer Assoc. 2000;32(6):1043-1049.

Abstract PDF: PURPOSE
The growth regulatory effect of retinoid derivatives could be mediated by the transcriptional inactivation of AP-1 oncogenic transcription factor. By using ovarian cancer cell lines we were to investigate the cross-regulation mechanism between retinoids and AP-1.
MATERIALS AND METHODS
Cell proliferation assays were performed in 4 ovarian cancer cells (A2774, PA-1, OVCAR-3, SKOV-3) by increasing the concentrations of all-trans retinoic acid (ATRA), 9-cis retinoic acid (9RA), 13-cis RA (13RA), 4-hydroxyphenyl retinamide (4-HPR). Transient transfection and CAT ELISA were done to determine the selective activity of each retinoid on the RAR (alpha, beta, gamma), RXR (alpha, beta, gamma). and the negative activity on AP-1 (c-Jun).
RESULTS
Antiproliferative effect of 4-HPR (IC50; 0.7~2.7 micrometer) was more potent than those of other retinoid derivatives (IC50; 2.7~9.0 micrometer). To assess the anticancer mechanism, we examined the effect of 4-HPR on the transriptional activity of retinoic acid receptors (RAR/RXR) and of c-jun. Contrary to other retinoid derivatives that are active for RAR and RXR with some different levels, 4-HPR showed weak activity only for RARgamma. However, 4-HPR exerted the strongest suppression on AP-1 (c-Jun) activity.
CONCLUSION
Based on our results showing much 4-HPR's potent antiproliferative activity coupled with the most effectively inhibiting activity on AP-1 and minimum activity on RA receptor (selective for RARgamma) than other retinoid derivatives, we suggest that 4-HPR may be a novel, and very effective anticancer drugs for ovarian cancer.

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The Effects of Interferon/Retinoic Acid on Cervical Cancer Cell Lines According to the Mutational Status of HPV-URR: Tae Yeon Kim, Chan Joo Kim, Eun Joo Kim, Tae Chul Park, Sung Eun Namkoong, Jae Gahb Park, Soo Jong Um, Jong Sup Park; J Korean Cancer Assoc. 2000;32(5):884-894.

Abstract PDF: PURPOSE
We investigated the effects of all-trans-retinoic acid (ATRA) and/or interferon-gamma (IFN-gamma) on the growth of various cervical cancer cell lines and HPV E6/E7 expression. The relationships between the functional activities of HPV-URR and the growth inhibition were identified.
MATERIALS AND METHODS
Four groups of cell lines were included; i) with integrated form of HPV-16 DNA (SNU-17, CaSki), ii) episomal form of HPV-16 (SNU-523), iii) integrated form of HPV-18 (SNU-1160, HeLa) and iv) episomal form of HPV-18 (SNU-1245). The promoter activity of HPV-URR was confirmed by transient transfection assay in C33A using the HPV-18 URR-CAT reporter plasmid.
RESULTS
Selective mutation was detected in TEF-1 (transcriptional enhancer factor) binding site in SNU-17, and the activity of URR in SNU-17 was higher than that of the prototype. The proliferation was more inhibited in SNU-17 by IFN-gamma (10 ng/ml) than in SNU-902, CaSki and HeLa. The increase of the HPV-URR activity might play a role in the inhibition of growth by interferon-g. The expression of HPV-16 E6/E7 were significantly decreased by ATRA or IFN-gamma.
CONCLUSION
Point mutation at TEF-1 binding site of SNU-17 was related with the increased transcriptional activity of URR. Mutation in the HPV-URR and alteration of HPV-URR activity in SNU-17 might be related with significant growth suppression by IFN-gamma.

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Integration of HPV and the Antibody Respones to HPV Proteins in Patients with Cervical Cancer: Joon Mo Lee, Seung Jo Kim, Jong Sup Park, Sung Eun Namkoong, Chan Joo Kim, Tae Chul Park, Soo Jong Um; J Korean Cancer Assoc. 1998;30(6):1184-1197.

Abstract PDF: PURPOSE
HPV (human papillomavirus) are known as the major causative agent for development of cervical cancer. High-risk HPVs, especially HPV-16 /18 DNA, are often found to be integrated into the human genome in high grade CINs as well as cervial cancer. Investigation of the relationship between the genomic states of HPV genes and their antibody response against the HPV-16 Ll/L2 virus-like particles (VLPs) and the in vitro translated E6 and E7 proteins may help to explain the mechanism of HPV-related cervical carcinogenesis and host immune responses.
MATERIALS AND METHODS
Cervical cancer tissues obtained from 41 patients with cervical cancer were studied by PCR, Southern blot hybridization and the antibody response against HPV-16 Ll/L2 VLPs and HPV-16 E6, E7 proteins of serum were tested by ELISA and radioimmunoprecipitation assay (RIPA), respectively.
RESULTS
Integrated forms of the HPV-16 DNA were found in 23 of the 38 patients (60.5%). The HPV-16 positive cervial cancer patients had a significantly higher prevalence (39.5%; 15/38) of antibodies to HPV-16 Ll/L2 VLPs than 8.7% (2/28) of the the control group (p<0.05). Antibodies to HPV-16 Ll/L2 VLPs were more detectable in 60% (9/15) of the cervical cancer patients with episomal forms of HPV-16 DNA than those who having only integrated HPV-16 (26.1%; 6/23) (p<0.05). Antibodies to E6 and E7 proteins were positive in 36.8% (14/38) and 50% (19/38) of the patients with HPV-16 positive cervical cancer. And those were siginificantly higher than the positivities for the control group (8.3% and 2.8%), (p<0.05). The difference between seroreactivities to E6 and E7 proteins in the patients with episomal forms of HPV-16 DNA (pure episomal and mixed forms) and those with integrated froms of HPV-16 DNA was not significant (P>0.05). CONCLUSION: Integrated forms of HPV-16 DNA were prevalent in most patients with cervical cancer. Antibodies to HPV-16 Ll/L2 VLPs, in vitro translated HPV-16 E6 and E7 proteins appeared in the significantly larger proportions of the HPV-associated cervical cancer patients than in the controls. Antibodies to HPV-16 Ll/L2 VLPs were more detectable in the cervical cancer patients with episomal form of HPV-16 DNA than those who having only integrated forms of HPV-16. Antibody responses to HPV-16 E6 and E7 proteins were not influenced by the different viral states. More numbers of studies would be necessary to determine the relationship between the genomic states of HPV and the immune responses to their proteins by the such genomic and serologic parameters.

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Clinical Trial of Concomitant Thermo - Chemotherapy in Cervix Cancer Patients: Hong Seok Jang, Sei Chul Yoon, Su Mi Chung, Mi Ryeong Ryu, Yeon Shil Kim, Jong Sup Park, Sung Eun NamKoong, Seung Jo Kim, Kyung Sub Shinn; J Korean Cancer Assoc. 1995;27(6):968-978.

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