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Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma
Jinhyun Choi, Se-Heon Kim, Yoon Woo Koh, Eun Chang Choi, Chang Geol Lee, Ki Chang Keum
Cancer Res Treat. 2017;49(1):178-184.   Published online July 4, 2016
DOI: https://doi.org/10.4143/crt.2016.165
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to evaluate the clinical outcomes of patients treated with radiotherapy (RT) for a carcinoma of the external auditory canal (EAC) and middle ear.
Materials and Methods
The records of 32 patients who received RT from 1990 to 2013 were reviewed retrospectively. The Pittsburgh classification was used to stage all the cancers (early stage, T1/T2 [n=12]; advanced stage, T3/T4 or N positive [n=20]). Twenty-one patients (65.6%) were treated with postoperative RT and 11 patients (34.4%) were treated with definitive RT. The median radiation doses for postoperative and definitive RT were 60 Gy and 64.8 Gy, respectively. Chemotherapy was administered to seven patients (21.9%).
Results
The 5-year overall survival and disease-free survival rates for all patients were 57% and 52%, respectively. The disease control rates for the patients with early stage versus advanced stage carcinomawere 55.6% (5/9) and 50% (6/12) in the postoperative RT group and 66.7% (2/3) and 37.5% (3/8) in the definitive RT group, respectively. Overall, 15 cases (14 patients, 46.7%) experienced treatment failure; these failures were classified as local in four cases, regional in one case, and distant in 10 cases. The median follow-up period after RT was 51 months (range, 7 to 286 months).
Conclusion
Patients with early stage carcinoma achieved better outcomes when definitive RT was used. Advanced stage carcinoma patients experienced better outcomes with postoperative RT. The high rate of distant failure after RT, with or without surgery, reflected the lack of a consensus regarding the best therapeutic approach for treating carcinoma of the EAC and middle ear.

Citations

Citations to this article as recorded by  
  • Survival Outcomes of Temporal Bone Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis
    Krystelle Sioufi, Aaron David Haynes, Paul W. Gidley, Anastasios Maniakas, Dianna Roberts, Marc‐Elie Nader
    Otolaryngology–Head and Neck Surgery.2024; 171(1): 1.     CrossRef
  • The international expert consensus on management of external auditory canal carcinoma
    Pei Zhou, Rubens de Brito, Yong Cui, Simon Lloyd, Henricus Kunst, J. Walter Kutz, Navin Mani, In Seok Moon, Badr Eldin Mostafa, Cindy Nabuurs, Sampath Chandra Prasad Rao, Bingbin Xie, Yibo Zhang, Chunfu Dai
    European Archives of Oto-Rhino-Laryngology.2024;[Epub]     CrossRef
  • Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal
    Cindy Nabuurs, Wietske Kievit, Charles Leemans, Conrad Smit, Michiel van den Brekel, Robert Pauw, Bernard van der Laan, Jeroen Jansen, Martin Lacko, Weibel Braunius, Chunfu Dai, Xunbei Shi, Giovanni Danesi, Jan Bouček, Daniele Borsetto, Shravan Gowrishank
    Cancers.2024; 16(23): 4026.     CrossRef
  • Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience
    Yongbo Zheng, Ke Qiu, Yangju Fu, Wenjie Yang, Danni Cheng, Yufang Rao, Minzi Mao, Yao Song, Wei Xu, Jianjun Ren, Yu Zhao
    Cancer Medicine.2023; 12(5): 5304.     CrossRef
  • Analysis of Prognostic Factors For External Auditory Canal Carcinoma: A 22‐Year Experience
    Isabelle J. H. Jang, Jiun Fong Thong, Constance E. H. Teo, Kiattisa Sommat
    The Laryngoscope.2023; 133(9): 2203.     CrossRef
  • Neoadjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma: Expecting Its Application in Temporal Bone Squamous Cell Carcinoma
    Meng-wen Shi, Jing Huang, Yu Sun
    Current Medical Science.2023; 43(2): 213.     CrossRef
  • Preoperative simulation using three‐dimensional printer in four temporal bone surgeries
    Ichiro Fukumoto, Yukiyoshi Mita, Rie Shimmi, Yuri Sonobe, Tomohisa Iinuma, Kazuki Yamasaki, Shuji Yonekura, Toshimitsu Nemoto, Toyoyuki Hanazawa
    Clinical Case Reports.2023;[Epub]     CrossRef
  • The Efficacy of Radiotherapy without Surgery for External Auditory Canal Squamous Cell Carcinoma
    Naoto Osu, Atsushi Musha, Hikaru Yumisaki, Kohei Okada, Nobuteru Kubo, Naoko Okano, Yukihiko Takayasu, Masato Shino, Osamu Nikkuni, Shota Ida, Hidemasa Kawamura, Kazuaki Chikamatsu, Tatsuya Ohno
    Journal of Clinical Medicine.2022; 11(19): 5905.     CrossRef
  • Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma
    Ke Qiu, Wendu Pang, Jianqing Qiu, Junhong Li, Danni Cheng, Yufang Rao, Yijun Dong, Minzi Mao, Qiurui Liu, Xiaosong Mu, Wei Zhang, Wei Xu, Jianjun Ren, Yu Zhao
    Cancer Medicine.2021; 10(22): 7958.     CrossRef
  • Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal
    Cindy H. Nabuurs, Wietske Kievit, Nilou Labbé, C. René Leemans, Conrad F. G. M. Smit, Michiel W. M. van den Brekel, Robert J. Pauw, Bernard F. A. M. van der Laan, Jeroen C. Jansen, Martin Lacko, Weibel W. Braunius, Shinya Morita, Małgorzata Wierzbicka, Ta
    Head & Neck.2020; 42(12): 3609.     CrossRef
  • Management of Temporal Bone Malignancy in Ireland
    Robbie S. R. Woods, Anel Naude, John Barry O'Sullivan, Daniel Rawluk, Mohsen Javadpour, Peter Walshe, Peter D. Lacy, James Paul O'Neill, Rory McConn-Walsh
    Journal of Neurological Surgery Part B: Skull Base.2020; 81(06): 680.     CrossRef
  • A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas
    Kazuhiko Hayashi, Masashi Koto, Yusuke Demizu, Jun‐ichi Saitoh, Hiroaki Suefuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Hiroaki Ikawa, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
    Cancer Medicine.2019; 8(1): 51.     CrossRef
  • Squamous cell carcinoma of the temporal bone: A current review
    Benjamin D. Lovin, Paul W. Gidley
    Laryngoscope Investigative Otolaryngology.2019; 4(6): 684.     CrossRef
  • Carcinoma of middle ear
    Dragoslava Đerić
    Биомедицинска истраживања.2019; 10(2): 179.     CrossRef
  • Surgery With or Without Postoperative Radiation Therapy for Early-stage External Auditory Canal Squamous Cell Carcinoma: A Meta-analysis
    Ryohei Oya, Yukinori Takenaka, Kazuya Takemura, Naoki Ashida, Kotaro Shimizu, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
    Otology & Neurotology.2017; 38(9): 1333.     CrossRef
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  • 16 Web of Science
  • 15 Crossref
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Predictive Factors for Radiation Pneumonitis in Lung Cancer Treated with Helical Tomotherapy
Youngkyong Kim, Seong Eon Hong, Moonkyoo Kong, Jinhyun Choi
Cancer Res Treat. 2013;45(4):295-302.   Published online December 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.4.295
AbstractAbstract PDFPubReaderePub
PURPOSE
Predictive factors for radiation pneumonitis (RP) after helical tomotherapy (HT) may differ from those after linac-based radiotherapy. In this study, we identified predictive factors for RP in patients with lung cancer treated with HT.
MATERIALS AND METHODS
We retrospectively analyzed clinical, treatment-related and dosimetric factors from 31 patients with lung cancer treated with HT. RP was graded according to Common Terminology Criteria for Adverse Events version 4.0 and grade > or =2 RP was defined as a RP event. We used Kaplan-Meier methods to compute the actuarial incidence of RP. For univariate and multivariate analysis, the log-rank test and the Cox proportional regression hazard model were used. We generated receiver-operating characteristics (ROC) curves to define the cutoff values for significant parameters.
RESULTS
The median follow-up duration was 6.6 months (range, 1.6 to 38.5 months). The 2-, 4-, and 6-month actuarial RP event rates were 13.2%, 58.5%, and 67.0%, respectively. There was no grade 4 or more RP. Ipsilateral V5, V10, V15, and contralateral V5 were related with RP event on univariate analysis. By multivariate analysis, ipsilateral V10 was factor most strongly associated with RP event. On the ROC curve, the cutoff values of ipsilateral V5, V10, V15, and contralateral V5 were 67.5%, 58.5%, 50.0%, and 55.5%, respectively.
CONCLUSION
In our study, ipsilateral V5, V10, V15, and contralateral V5 were significant predictive factors for RP after HT.

Citations

Citations to this article as recorded by  
  • Predictive factors for severe radiation-induced lung injury in patients with lung cancer and coexisting interstitial lung disease
    Shin-Hyung Park, Jae-Kwang Lim, Min Kyu Kang, Jongmoo Park, Chae Moon Hong, Chang Ho Kim, Seung Ick Cha, Jaehee Lee, Seoung-Jun Lee, Jae-Chul Kim
    Radiotherapy and Oncology.2024; 192: 110053.     CrossRef
  • Deep-Learning Model Prediction of Radiation Pneumonitis Using Pretreatment Chest Computed Tomography and Clinical Factors
    Jang Hyung Lee, Min Kyu Kang, Jongmoo Park, Seoung-Jun Lee, Jae-Chul Kim, Shin-Hyung Park
    Technology in Cancer Research & Treatment.2024;[Epub]     CrossRef
  • Pulmonary toxicity of craniospinal irradiation using helical tomotherapy
    Joongyo Lee, Euidam Kim, Nalee Kim, Chang-Ok Suh, Yoonsun Chung, Hong In Yoon
    Scientific Reports.2022;[Epub]     CrossRef
  • Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors
    Xin Zhang, Dingyi Yang, Yong Jiang, Luo Huang, Can Wang, Dan Tao, Xianfeng Liu, Yongyang Lei, Yongzhong Wu, Wei Zhou
    Journal of Inflammation Research.2021; Volume 14: 4205.     CrossRef
  • The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer: A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study
    Moonkyoo Kong, Seung Hyeun Lee, Jaehyo Kim, Beom-Joon Lee, Kwan-Il Kim
    Integrative Cancer Therapies.2020;[Epub]     CrossRef
  • Phase II study of compensator-based non-coplanar intensity-modulated radiotherapy for Stage I non–small-cell lung cancer
    Tomohiro Itonaga, Ryuji Mikami, Hidetsugu Nakayama, Tatsuhiko Saito, Sachika Shiraishi, Mitsuru Okubo, Shinji Sugahara, Norihiko Ikeda, Koichi Tokuuye
    Journal of Radiation Research.2019; 60(3): 387.     CrossRef
  • Dosimetric Comparison Between Jaw Tracking and No Jaw Tracking in Intensity-Modulated Radiation Therapy
    Shengyu Yao, Yin Zhang, Tingfeng Chen, Guoqi Zhao, Zhekai Hu, Xiaokai Lu, Yong Liu
    Technology in Cancer Research & Treatment.2019;[Epub]     CrossRef
  • A new Monte Carlo model of a Cyberknife® system for the precise determination of out-of-field doses
    J Colnot, V Barraux, C Loiseau, P Berejny, A Batalla, R Gschwind, C Huet
    Physics in Medicine & Biology.2019; 64(19): 195008.     CrossRef
  • Treatment outcomes and patterns of radiologic appearance after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) for lung tumours
    Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
    The British Journal of Radiology.2017;[Epub]     CrossRef
  • Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC
    S Arcangeli, L Agolli, L Portalone, M R Migliorino, M G Lopergolo, A Monaco, J Dognini, M C Pressello, S Bracci, V Donato
    The British Journal of Radiology.2015; 88(1048): 20140728.     CrossRef
  • Early Toxicity in Patients Treated With Postoperative Proton Therapy for Locally Advanced Breast Cancer
    John J. Cuaron, Brian Chon, Henry Tsai, Anuj Goenka, David DeBlois, Alice Ho, Simon Powell, Eugen Hug, Oren Cahlon
    International Journal of Radiation Oncology*Biology*Physics.2015; 92(2): 284.     CrossRef
  • Risk of radiation-induced pneumonitis after helical and static-port tomotherapy in lung cancer patients and experimental rats
    Xianglan Zhang, You Keun Shin, Zhenlong Zheng, Lianhua Zhu, Ik Jae Lee
    Radiation Oncology.2015;[Epub]     CrossRef
  • Dosimetric Comparisons of Lung SBRT with Multiple Metastases by Two Advanced Planning Systems
    Ye Zhang, Yie Chen, Jie Qiu, Jack Yang
    International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.2014; 03(04): 252.     CrossRef
  • Frameless stereotactic body radiation therapy for multiple lung metastases
    Qilin Li, Jinming Mu, Wendong Gu, Yuan Chen, Zhonghua Ning, Jianxue Jin, Honglei Pei
    Journal of Applied Clinical Medical Physics.2014; 15(4): 105.     CrossRef
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  • 71 Download
  • 14 Crossref
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Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors
Moonkyoo Kong, Seong Eon Hong, Woo Suk Choi, Si-Young Kim, Jinhyun Choi
Cancer Res Treat. 2012;44(2):104-112.   Published online June 30, 2012
DOI: https://doi.org/10.4143/crt.2012.44.2.104
AbstractAbstract PDFPubReaderePub
PURPOSE
This study was designed to investigate the long-term oncologic outcomes for locally advanced rectal cancer patients after treatment with preoperative concurrent chemoradiotherapy followed by total mesorectal excision, and to identify prognostic factors that affect survival and pathologic response.
MATERIALS AND METHODS
From June 1996 to June 2009, 135 patients with locally advanced rectal cancer were treated with preoperative concurrent chemoradiotherapy followed by total mesorectal excision at Kyung Hee University Hospital. Patient data was retrospectively collected and analyzed in order to determine the treatment outcomes and identify prognostic factors for survival.
RESULTS
The median follow-up time was 50 months (range, 4.5 to 157.8 months). After preoperative chemoradiotherapy, sphincter preservation surgery was accomplished in 67.4% of whole patients. A complete pathologic response was achieved in 16% of patients. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for all patients was 82.7% and 75.7%, 76.8% and 71.9%, 67.9% and 63.3%, respectively. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for pathologic complete responders was 100% and 100%, 100% and 88.9%, 95.5% and 95.5%, respectively. In the multivariate analysis, pathologic complete response was significantly associated with overall survival. The predictive factor for pathologic complete response was pretreatment clinical stage.
CONCLUSION
Preoperative chemoradiotherapy for locally advanced rectal cancer resulted in a high rate of overall survival, sphincter preservation, down-staging, and pathologic complete response. The patients achieving pathologic complete response had very favorable outcomes. Pathologic complete response was a significant prognostic factor for overall survival and the significant predictive factor for a pathologic complete response was pretreatment clinical stage.

Citations

Citations to this article as recorded by  
  • Characteristics of Patients Presented With Metastases During or After Completion of Chemoradiation Therapy for Locally Advanced Rectal Cancer: A Case Series
    Radwan Torky, Mohammed Alessa, Ho Seung Kim, Ahmed Sakr, Eman Zakarneh, Fozan Sauri, Heejin Bae, Nam Kyu Kim
    Annals of Coloproctology.2021; 37(3): 186.     CrossRef
  • A prospective analysis of the diagnostic accuracy of 3 T MRI, CT and endoscopic ultrasound for preoperative T staging of potentially resectable esophageal cancer
    Jia Guo, Zhaoqi Wang, Jianjun Qin, Hongkai Zhang, Wentao Liu, Yan Zhao, Yanan Lu, Xu Yan, Zhongxian Zhang, Ting Zhang, Shouning Zhang, Nickel Marcel Dominik, Ihab R. Kamel, Hailiang Li, Jinrong Qu
    Cancer Imaging.2020;[Epub]     CrossRef
  • Sustaining Blood Lymphocyte Count during Preoperative Chemoradiotherapy as a Predictive Marker for Pathologic Complete Response in Locally Advanced Rectal Cancer
    Jaesung Heo, Mison Chun, O Kyu Noh, Young-Taek Oh, Kwang Wook Suh, Jun Eun Park, Oyeon Cho
    Cancer Research and Treatment.2016; 48(1): 232.     CrossRef
  • Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer
    Ikuko Kato, Gregory Dyson, Michael Snyder, Hyeong-Reh Kim, Richard K. Severson
    Journal of Radiation Oncology.2016; 5(3): 279.     CrossRef
  • JOURNAL CLUB: Preoperative MRI Evaluation of Primary Rectal Cancer: Intrasubject Comparison With and Without Rectal Distention
    Feng Ye, Hongmei Zhang, Xiao Liang, Han Ouyang, Xinming Zhao, Chunwu Zhou
    American Journal of Roentgenology.2016; 207(1): 32.     CrossRef
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    The Egyptian Journal of Radiology and Nuclear Medicine.2016; 47(4): 1243.     CrossRef
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    Daniel G Couch
    World Journal of Gastroenterology.2016; 22(2): 467.     CrossRef
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    Samah Kohla
    Polish Journal of Radiology.2015; 80: 115.     CrossRef
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    Gennaro Galizia, Eva Lieto, Ferdinando De Vita, Francesca Ferraraccio, Anna Zamboli, Andrea Mabilia, Annamaria Auricchio, Paolo Castellano, Vincenzo Napolitano, Michele Orditura
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    Elsa Iannicelli, Sara Di Renzo, Mario Ferri, Emanuela Pilozzi, Marco Di Girolamo, Alessandra Sapori, Vincenzo Ziparo, Vincenzo David
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    Gunther Klautke
    Info Onkologie.2014; 17(6): 17.     CrossRef
  • Sphincter preservation in distal CT2N0 rectal cancer after preoperative chemoradiotherapy
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  • Metformin use and improved response to therapy in rectal cancer
    Heath D. Skinner, Christopher H. Crane, Christopher R. Garrett, Cathy Eng, George J. Chang, John M. Skibber, Miguel A. Rodriguez‐Bigas, Patrick Kelly, Vlad C. Sandulache, Marc E. Delclos, Sunil Krishnan, Prajnan Das
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  • 15 Crossref
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