Cancer Research and Treatment

Original Articles

Hematologic malignancy

Efficacy of Salvage Treatments in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Including Chimeric Antigen Receptor T-Cell Therapy: A Systematic Review and Meta-Analysis: Jinchul Kim, Jinhyun Cho, Sang Eun Yoon, Won Seog Kim, Seok Jin Kim; Cancer Res Treat. 2023;55(3):1031-1047. Published online March 13, 2023; DOI: https://doi.org/10.4143/crt.2022.1658

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Purpose
We intend to evaluate the efficacy of salvage treatments for relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) through meta-analysis.
Materials and Methods
R/R DLBCL trials were divided into two groups based on eligibility for autologous stem-cell transplantation (ASCT), and meta-analysis of each group was performed. Random effects models were used to estimate the 1-year progression-free survival (PFS) rate, and chimeric antigen receptor (CAR) T-cell therapy was used as reference treatment.
Results
Twenty-six ASCT-eligible cohorts from 17 studies comprising 2,924 patients and 59 ASCT-ineligible cohorts from 53 studies comprising 3,617 patients were included in the pooled analysis. In the ASCT-eligible group, the pooled 1-year PFS rate was 0.40 (95% confidence interval [CI], 0.15 to 0.65) for the CAR T-cell group and 0.34 (95% CI, 0.30 to 0.37) for the group with chemotherapy followed by ASCT intention. The two treatments were not significantly different in meta-regression analysis. In the ASCT-ineligible group, the pooled 1-year PFS was 0.40 (95% CI, 0.35 to 0.46) for CAR T-cell, and the highest primary outcome was 0.47 (95% CI, 0.37 to 0.57) for the tafasitamab group. CAR T-cell therapy showed significantly better outcomes than chemotherapy and therapies based on ibrutinib, lenalidomide, and selinexor. However, loncastuximab, polatuzumab plus bendamustine and rituximab, and the tafasitamab group showed no different efficacy than CAR T-cell therapy after adjusting for median number of previous lines of treatment.
Conclusion
Although several regimens were crudely grouped for classification, CAR T-cell therapy did not outperform chemotherapy followed by ASCT in the second-line setting or several recently developed agents in the ASCT-ineligible setting.

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Real-World Effectiveness of Chemoimmunotherapy and Novel Therapies for Patients With Relapsed/Refractory Aggressive Large B-Cell Lymphoma
Loretta J. Nastoupil, Clark R. Andersen, Amy Ayers, Yucai Wang, Thomas M. Habermann, Dai Chihara, Brad S. Kahl, Brian K. Link, Jean L. Koff, Jonathon B. Cohen, Peter Martin, Izidore S. Lossos, Michele Stanchina, Sara Haddadi, Carla Casulo, Sabarish Ayyapp
Clinical Lymphoma Myeloma and Leukemia.2025; 25(4): e183. CrossRef
Efficacy and safety of polatuzumab-vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma: A systematic review and meta-analysis
Hanzala Ahmed Farooqi, Muhammad Saffi Ullah, Ahmed Raza, Zain Sadiq, Wardah Ali Shaikh, Rahmah Muhammad, Muhammad Shoaib Hussain
Critical Reviews in Oncology/Hematology.2025; 207: 104611. CrossRef
Efficacy and Safety of Chimeric Antigen Receptor (CAR)-T Cell Therapy in Patients with Non-Hodgkin Lymphoma
Abdur Jamil, Zaheer Qureshi, Rimsha Siddique, Faryal Altaf, Hamzah Akram, Rohma Jamil, Shehroz Aslam, Insija I. Selene
American Journal of Clinical Oncology.2025;[Epub] CrossRef
Improving access to chimeric antigen receptor T-cells for refractory or relapsing diffuse large B cell lymphoma therapy in Asia
Ya Hwee Tan, Dok Hyun Yoon, Andrew J. Davies, Christian Buske, Yang Liang Boo, Nagavalli Somasundaram, Francesca Lim, Shin Yeu Ong, Anand Jeyasekharan, Koji Izutsu, Won Seog Kim, Jason Yongsheng Chan
Discover Oncology.2025;[Epub] CrossRef
Luteolin inhibits diffuse large B-cell lymphoma cell growth through the JAK2/STAT3 signaling pathway
Xin-Zhuo Zhan, Yi-Wen Bo, Yu Zhang, Hai-Dong Zhang, Zhi-Hao Shang, Hui Yu, Xiao-Li Chen, Xiang-Tu Kong, Wan-Zhou Zhao, Timo Teimonen, Tao Liu, Meng-Yi Lu, Ye Yang, Shan-Liang Sun, Hai-Wen Ni
Frontiers in Pharmacology.2025;[Epub] CrossRef
Polatuzumab vedotin combined with bendamustine and rituximab for relapsed/refractory diffuse large B-cell lymphoma: A systematic review protocol
Mohammadreza Eslami, Mahdi Mehrabi, Mehrdad Payandeh, Fakhredin Saba, Chen Li
PLOS ONE.2024; 19(8): e0308247. CrossRef
Clinical scoring systems, molecular subtypes and baseline [18F]FDG PET/CT image analysis for prognosis of diffuse large B-cell lymphoma
Zhuxu Sun, Tianshuo Yang, Chongyang Ding, Yuye Shi, Luyi Cheng, Qingshen Jia, Weijing Tao
Cancer Imaging.2024;[Epub] CrossRef
Targeting CD22 for B-cell hematologic malignancies
Jia Xu, Wenjing Luo, Chenggong Li, Heng Mei
Experimental Hematology & Oncology.2023;[Epub] CrossRef

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Early Decline in Left Ventricular Ejection Fraction Can Predict Trastuzumab-Related Cardiotoxicity in Patients with Breast Cancer: A Study Using 13 Years of Registry Data: Eun Kyoung Kim, Jinhyun Cho, Ji-Yeon Kim, Sung-A Chang, Sung-Ji Park, Jin Oh Choi, Sang Chol Lee, Jin Seok Ahn, Seung Woo Park, Young-Hyuck Im, Eun Seok Jeon, Yeon Hee Park; Cancer Res Treat. 2019;51(2):727-736. Published online September 4, 2018; DOI: https://doi.org/10.4143/crt.2018.262

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Purpose
While concerns regarding trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer are increasing, there is a lack of evidence supporting the current recommendations for TRCD monitoring. We aimed to investigate the clinical predictors of TRCD in the adjuvant setting of human epidermal growth factor receptor 2–positive breast cancer patients.
Materials and Methods
From August 2003 to April 2016, consecutive 998 patients who were treated with adjuvant trastuzumab for breast cancer were retrospectively evaluated. TRCD was defined as a decrease ≥10% in left ventricular ejection fraction (LVEF), with a decline below the normal limit or symptomatic heart failure.
Results
Among 787 eligible patients who had complete data sets consisting of both baseline and follow-up assessment of left ventricular systolic function by echocardiography (mean age, 49.9±9.5 years), 58 (7.4%) developed TRCD. TRCD patients had lower baseline LVEF (63% [59–66] vs. 65% [61–68], p=0.016) and more frequently administered Adriamycin (98% vs. 89%, p=0.022) than those without TRCD. On follow-up echocardiography, a drop in LVEF ≥5% within the first 3 months was more frequent in TRCD patients (78.3% vs. 38.4%, p<0.001). Regardless of baseline LVEF and Adriamycin treatment, a drop in LVEF ≥5% within the first 3 months of trastuzumab administration was strongly associated with the development of TRCD (adjusted hazard ratio, 45.1[17.0–127.6], p<0.001).
Conclusion
The overall incidence of TRCD was 7.4% in Asian breast cancer patients treated with adjuvant trastuzumab. A decline in LVEF ≥5% within the first 3 months of trastuzumab initiation was strongly associated with TRCD development in patients with breast cancer.

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Noninvasive identification and therapeutic implications of supernormal left ventricular contractile phenotype
Yi Wang, Lixue Yin
Exploration of Cardiology.2024; 2(3): 97. CrossRef
Significant Influence of Cardiac Radiation Dose on the Risk of Cardiotoxicity in Patients Receiving Adjuvant Trastuzumab and Radiation Therapy for Breast Cancer
Tae Hoon Lee, Nalee Kim, Eun Kyoung Kim, Jin Seok Ahn, Yeon Hee Park, Seok Won Kim, Jeong Eon Lee, Jonghan Yu, Byung Joo Chae, Se Kyung Lee, Won Kyung Cho, Won Park, Tae Gyu Kim, Jee Suk Chang, Haeyoung Kim
International Journal of Radiation Oncology*Biology*Physics.2024;[Epub] CrossRef
ABSDELL Model: Development and Internal Validation of a Risk Prediction Model of LVEF Decline in Breast Cancer Patients Treated With Trastuzumab
Xin Liu, Liyuan Tao, Mopei Wang, Haiyan Li, Weixian Xu
Clinical Breast Cancer.2023; 23(1): 23. CrossRef
New Insights in the Era of Clinical Biomarkers as Potential Predictors of Systemic Therapy-Induced Cardiotoxicity in Women with Breast Cancer: A Systematic Review
Alexia Alexandraki, Elisavet Papageorgiou, Marina Zacharia, Kalliopi Keramida, Andri Papakonstantinou, Carlo M. Cipolla, Dorothea Tsekoura, Katerina Naka, Ketti Mazzocco, Davide Mauri, Manolis Tsiknakis, Georgios C. Manikis, Kostas Marias, Yiola Marcou, E
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Douglas J. Leedy, Marta Alhama-Belotto, William R. Gwin, Ruchi Kapoor, Elina Minami, Eric J. Chow, Richard K. Cheng
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Cardiovascular adverse events of antineoplastic monoclonal antibodies among cancer patients: real-world evidence from a tertiary healthcare system
Abdulrazaq S. Al-Jazairi, Nahlah Bahammam, Dhai Aljuaid, Lama Almutairi, Shroog Alshahrani, Norah Albuhairan, Peter M. B. Cahusac, Ghazwa B. Korayem
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Cardio-Oncology.2023;[Epub] CrossRef
Deceleration capacity of heart rate predicts trastuzumab‐related cardiotoxicity in patients with HER2‐positive breast cancer: A prospective observational study
Yanying Feng, Zhenhua Qin, Zhijun Yang
Journal of Clinical Pharmacy and Therapeutics.2021; 46(1): 93. CrossRef
Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study
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Liliana Maria Radulescu, Dan Radulescu, Tudor-Eliade Ciuleanu, Dana Crisan, Elena Buzdugan, Dragos-Mihai Romitan, Anca Dana Buzoianu
Medicina.2021; 57(8): 806. CrossRef
Successful Use of Digoxin for Trastuzumab-related Cardiotoxicity to Facilitate Breast Surgery in a Patient with Metastatic Breast Cancer
Tsuyoshi SHIGA, Takako KAMIO, Kenta UTO, Kotaro ARAI
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics .2021; 52(4): 101. CrossRef
Treatment with Beta-Blockers and ACE-Inhibitors in Breast Cancer Patients Receiving Adjuvant Trastuzumab-Based Therapy and Developing Mild Cardiac Toxicity: A Prospective Study
Elena Geuna, Pasquale Lombardi, Rossella Martinello, Davide Garino, Alessandro Bonzano, Danilo Galizia, Annamaria Nuzzo, Paola Berchialla, Paolo Becco, Monica Mangioni, Lorena De Zarlo, Filippo Montemurro
Cancers.2020; 12(2): 327. CrossRef
A Prospective Study About Trastuzumab-induced Cardiotoxicity in HER2-positive Breast Cancer
Wala Ben Kridis, Syrine Sghaier, Salma Charfeddine, Nabil Toumi, Jamel Daoud, Samir Kammoun, Afef Khanfir
American Journal of Clinical Oncology.2020; 43(7): 510. CrossRef
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Neelima Denduluri
JACC: CardioOncology.2020; 2(2): 176. CrossRef
Determinants of left ventricular ejection fraction and a novel method to improve its assessment of myocardial contractility
Manuel Ignacio Monge García, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib, Michael R. Pinsky
Annals of Intensive Care.2019;[Epub] CrossRef
The Role of Echocardiography in Cardio-oncology Patients: Contemporary Indications and Future Directions
Saiuj Bhat, Nestor Gahungu, Paaladinesh Thavendiranathan, Girish Dwivedi
Current Cardiovascular Imaging Reports.2019;[Epub] CrossRef
Novel HER2-Targeting Antibody-Drug Conjugates of Trastuzumab Beyond T-DM1 in Breast Cancer: Trastuzumab Deruxtecan(DS-8201a) and (Vic-)Trastuzumab Duocarmazine (SYD985)
Zhuyu Xu, Dandan Guo, Zhongliang Jiang, Rongsheng Tong, Peidu Jiang, Lan Bai, Lu Chen, Yuxuan Zhu, Chun Guo, Jianyou Shi, Dongke Yu
European Journal of Medicinal Chemistry.2019; 183: 111682. CrossRef

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A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First-Line EGFR Tyrosine Kinase Inhibitor: KCSG-LU12-13: Kwai Han Yoo, Su Jin Lee, Jinhyun Cho, Ki Hyeong Lee, Keon Uk Park, Ki Hwan Kim, Eun Kyung Cho, Yoon Hee Choi, Hye Ryun Kim, Hoon-Gu Kim, Heui June Ahn, Ha Yeon Lee, Hwan Jung Yun, Jin-Hyoung Kang, Jaeheon Jeong, Moon Young Choi, Sin-Ho Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn; Cancer Res Treat. 2019;51(2):718-726. Published online September 3, 2018; DOI: https://doi.org/10.4143/crt.2018.324

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Purpose
The optimal cytotoxic regimens have not been established for patients with non-small cell lung cancer (NSCLC) who develop disease progression on first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).
Materials and Methods
We conducted a multi-center randomized phase II trial to compare the clinical outcomes between pemetrexed plus cisplatin combination therapy followed by maintenance pemetrexed (PC) and pemetrexed monotherapy (P) after failure of first-line EGFR-TKI. The primary objective was progression-free survival (PFS), and secondary objectives included overall response rate (ORR), overall survival (OS), health-related quality of life (HRQOL), and safety and toxicity profiles.
Results
A total of 96 patientswere randomized, and 91 patientswere treated at 14 centers in Korea. The ORR was 34.8% (16/46) for the PC arm and 17.8% (8/45) for the P arm (p=0.066). With 23.4 months of follow-up, the median PFS was 5.4 months in the PC arm and 6.4 months in the P arm (p=0.114). The median OS was 17.9 months and 15.7 months in PC and P arms, respectively (p=0.787). Adverse events ≥ grade 3 were reported in 12 patients (26.1%) in the PC arm and nine patients (20.0%) in the P arm (p=0.491). The overall time trends of HRQOL were not significantly different between the two arms.
Conclusion
The outcomes of pemetrexed therapy in NSCLC patients with disease progression after firstline EGFR-TKI might not be improved by adding cisplatin.

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The Survival and Financial Benefit of Investigator-Initiated Trials Conducted by Korean Cancer Study Group
Bum Jun Kim, Chi Hoon Maeng, Bhumsuk Keam, Young-Hyuck Im, Jungsil Ro, Kyung Hae Jung, Seock-Ah Im, Tae Won Kim, Jae Lyun Lee, Dae Seog Heo, Sang-We Kim, Keunchil Park, Myung-Ju Ahn, Byoung Chul Cho, Hoon-Kyo Kim, Yoon-Koo Kang, Jae Yong Cho, Hwan Jung Yu
Cancer Research and Treatment.2025; 57(1): 39. CrossRef
A randomised non-comparative phase II study of atezolizumab, bevacizumab and chemotherapy in EGFR-mutant NSCLC with acquired resistance – The ETOP 15-19 ABC-lung trial
R.A. Soo, K. Vervita, M. Früh, B.C. Cho, M. Majem, D. Rodriguez Abreu, K. Ribi, A. Callejo, T. Moran, M. Domine Gomez, M. Provencio, A. Addeo, J.Y. Han, A.L. Ortega Granados, M. Reck, A. Blasco, R. Garcia Campelo, M.A. Sala González, C. Britschgi, H. Rosc
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Osimertinib with Chemotherapy in EGFR -Mutated NSCLC

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Balazs Halmos, Pragya Rai, Jae Min, Xiaohan Hu, Diana Chirovsky, Mark Shamoun, Bin Zhao
Frontiers in Oncology.2024;[Epub] CrossRef
Clinical efficacy and safety of pemetrexed with or without either Bevacizumab or Pembrolizumab in patients with metastatic nonsquamous non–small cell carcinoma
Wang Chun Kwok, Tan Fong Cheong, Ka Yan Chiang, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip, Terence Chi Chun Tam
Asia-Pacific Journal of Clinical Oncology.2023; 19(1): 87. CrossRef
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Cheng-Yu Chang, Chung-Yu Chen, Shih-Chieh Chang, Ching-Yi Chen, Yi-Chun Lai, Chun-Fu Chang, Yu-Feng Wei
Frontiers in Oncology.2023;[Epub] CrossRef
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JAMA Oncology.2022; 8(6): 879. CrossRef
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Ruizhu Sun, Zhansheng Hou, Yankui Zhang, Bo Jiang
Oncology Letters.2022;[Epub] CrossRef
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Journal of Chemotherapy.2020; 32(8): 429. CrossRef

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Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma: Jinhyun Choi, Se-Heon Kim, Yoon Woo Koh, Eun Chang Choi, Chang Geol Lee, Ki Chang Keum; Cancer Res Treat. 2017;49(1):178-184. Published online July 4, 2016; DOI: https://doi.org/10.4143/crt.2016.165

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Purpose
The purpose of this study was to evaluate the clinical outcomes of patients treated with radiotherapy (RT) for a carcinoma of the external auditory canal (EAC) and middle ear.
Materials and Methods
The records of 32 patients who received RT from 1990 to 2013 were reviewed retrospectively. The Pittsburgh classification was used to stage all the cancers (early stage, T1/T2 [n=12]; advanced stage, T3/T4 or N positive [n=20]). Twenty-one patients (65.6%) were treated with postoperative RT and 11 patients (34.4%) were treated with definitive RT. The median radiation doses for postoperative and definitive RT were 60 Gy and 64.8 Gy, respectively. Chemotherapy was administered to seven patients (21.9%).
Results
The 5-year overall survival and disease-free survival rates for all patients were 57% and 52%, respectively. The disease control rates for the patients with early stage versus advanced stage carcinomawere 55.6% (5/9) and 50% (6/12) in the postoperative RT group and 66.7% (2/3) and 37.5% (3/8) in the definitive RT group, respectively. Overall, 15 cases (14 patients, 46.7%) experienced treatment failure; these failures were classified as local in four cases, regional in one case, and distant in 10 cases. The median follow-up period after RT was 51 months (range, 7 to 286 months).
Conclusion
Patients with early stage carcinoma achieved better outcomes when definitive RT was used. Advanced stage carcinoma patients experienced better outcomes with postoperative RT. The high rate of distant failure after RT, with or without surgery, reflected the lack of a consensus regarding the best therapeutic approach for treating carcinoma of the EAC and middle ear.

Citations

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The international expert consensus on management of external auditory canal carcinoma
Pei Zhou, Rubens de Brito, Yong Cui, Simon Lloyd, Henricus Kunst, J. Walter Kutz, Navin Mani, In Seok Moon, Badr Eldin Mostafa, Cindy Nabuurs, Sampath Chandra Prasad Rao, Bingbin Xie, Yibo Zhang, Chunfu Dai
European Archives of Oto-Rhino-Laryngology.2025; 282(4): 1677. CrossRef
Survival Outcomes of Temporal Bone Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis
Krystelle Sioufi, Aaron David Haynes, Paul W. Gidley, Anastasios Maniakas, Dianna Roberts, Marc‐Elie Nader
Otolaryngology–Head and Neck Surgery.2024; 171(1): 1. CrossRef
Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal
Cindy Nabuurs, Wietske Kievit, Charles Leemans, Conrad Smit, Michiel van den Brekel, Robert Pauw, Bernard van der Laan, Jeroen Jansen, Martin Lacko, Weibel Braunius, Chunfu Dai, Xunbei Shi, Giovanni Danesi, Jan Bouček, Daniele Borsetto, Shravan Gowrishank
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Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience
Yongbo Zheng, Ke Qiu, Yangju Fu, Wenjie Yang, Danni Cheng, Yufang Rao, Minzi Mao, Yao Song, Wei Xu, Jianjun Ren, Yu Zhao
Cancer Medicine.2023; 12(5): 5304. CrossRef
Analysis of Prognostic Factors For External Auditory Canal Carcinoma: A 22‐Year Experience
Isabelle J. H. Jang, Jiun Fong Thong, Constance E. H. Teo, Kiattisa Sommat
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Ichiro Fukumoto, Yukiyoshi Mita, Rie Shimmi, Yuri Sonobe, Tomohisa Iinuma, Kazuki Yamasaki, Shuji Yonekura, Toshimitsu Nemoto, Toyoyuki Hanazawa
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Naoto Osu, Atsushi Musha, Hikaru Yumisaki, Kohei Okada, Nobuteru Kubo, Naoko Okano, Yukihiko Takayasu, Masato Shino, Osamu Nikkuni, Shota Ida, Hidemasa Kawamura, Kazuaki Chikamatsu, Tatsuya Ohno
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Ke Qiu, Wendu Pang, Jianqing Qiu, Junhong Li, Danni Cheng, Yufang Rao, Yijun Dong, Minzi Mao, Qiurui Liu, Xiaosong Mu, Wei Zhang, Wei Xu, Jianjun Ren, Yu Zhao
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Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal
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Robbie S. R. Woods, Anel Naude, John Barry O'Sullivan, Daniel Rawluk, Mohsen Javadpour, Peter Walshe, Peter D. Lacy, James Paul O'Neill, Rory McConn-Walsh
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Kazuhiko Hayashi, Masashi Koto, Yusuke Demizu, Jun‐ichi Saitoh, Hiroaki Suefuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Hiroaki Ikawa, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
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Benjamin D. Lovin, Paul W. Gidley
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Dragoslava Đerić
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Surgery With or Without Postoperative Radiation Therapy for Early-stage External Auditory Canal Squamous Cell Carcinoma: A Meta-analysis
Ryohei Oya, Yukinori Takenaka, Kazuya Takemura, Naoki Ashida, Kotaro Shimizu, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
Otology & Neurotology.2017; 38(9): 1333. CrossRef

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Clinicopathologic Features and Long-Term Outcomes of Elderly Breast Cancer Patients: Experiences at a Single Institution in Korea: Hee Kyung Kim, Jun Soo Ham, Seonggyu Byeon, Kwai Han Yoo, Ki Sun Jung, Haa-Na Song, Jinhyun Cho, Ji Yun Lee, Sung Hee Lim, Hae Su Kim, Ji-Yeon Kim, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Se Kyung Lee, Soo Youn Bae, Jin Seok Ahn, Young-Hyuck Im, Yeon Hee Park; Cancer Res Treat. 2016;48(4):1382-1388. Published online March 11, 2016; DOI: https://doi.org/10.4143/crt.2015.423

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to assess the tumor characteristics and long-term clinical outcomes of adjuvant treatments after surgery with a curative aim for patients with breast cancer who are 65 years and older. Materials and Methods Patients with breast cancer who underwent curative surgery from 2000 to 2009 were analyzed (n=4,388). Tumor characteristics and survival outcome were compared by dividing the patients into two age groups (< 65 and ≥ 65 years old). The Kaplan-Meier method was used for comparison of survival rates by log-rank test, and a Cox regression model was used to examine the effect of variables.
Results
Among 4,388 patients with invasive breast cancer, 317 patients (7.2%) were 65 years or older and the median age of all patients was 47 years (range, 18 to 91 years). Tumor characteristics were similar between the two age groups, but the older patients were treated less often with adjuvant treatments. During a median follow-up period of 122 months, recurrence-free survival (RFS) was equivalent for patients 65 years and older compared to younger patients, but significantly worse in overall survival (OS) and breast cancer–specific survival (BCSS) (5-year OS, 94.3% vs. 90.5%; p < 0.001 and 5-year BCSS, 94.7% vs. 91.8%; p=0.031). In the multivariate model, age ≥ 65 years old was identified as an independent risk factor for OS and RFS. Conclusion Elderly breast cancer appeared to have worse outcomes with very low prevalence in Korea, despite similar tumor characteristics. More active adjuvant therapies would have a role for aggressive subtypes for fit, elderly patients.

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Breast Cancer Research and Treatment.2021; 187(3): 785. CrossRef
Survival outcomes in elderly Taiwanese women according to breast cancer subtype and lymph node status: A single-center retrospective study
Kung-Hung Lin, Huan-Ming Hsu, Kuo-Feng Hsu, Chi-Hong Chu, Zhi-Jie Hong, Chun-Yu Fu, Yu-Ching Chou, Golshan Mehra, Ming-Shen Dai, Jyh-Cherng Yu, Guo-Shiou Liao, Jason Chia-Hsun Hsieh
PLOS ONE.2021; 16(12): e0261258. CrossRef
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The American Journal of Surgery.2020; 220(6): 1417. CrossRef
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Haruko Takuwa, Wakako Tsuji, Fumiaki Yotsumoto
Breast Disease.2018; 37(4): 177. CrossRef
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Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D’Alessandro, Paolo Marchetti, Silveri
Journal of Translational Medicine.2018;[Epub] CrossRef
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Majid Akrami, Afrooz Sepahdar, Peyman Arasteh, Sedigheh Tahmasebi, Vahid Zangouri, Azam Askari, Babak Pezeshki, Abdolrasoul Talei
World Journal of Surgical Oncology.2018;[Epub] CrossRef
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Jessemae L. Welsh, Tanya L. Hoskin, Courtney N. Day, Elizabeth B. Habermann, Matthew P. Goetz, Judy C. Boughey
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Predictive Factors for Radiation Pneumonitis in Lung Cancer Treated with Helical Tomotherapy: Youngkyong Kim, Seong Eon Hong, Moonkyoo Kong, Jinhyun Choi; Cancer Res Treat. 2013;45(4):295-302. Published online December 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.4.295

Abstract PDF PubReader ePub

PURPOSE
Predictive factors for radiation pneumonitis (RP) after helical tomotherapy (HT) may differ from those after linac-based radiotherapy. In this study, we identified predictive factors for RP in patients with lung cancer treated with HT.
MATERIALS AND METHODS
We retrospectively analyzed clinical, treatment-related and dosimetric factors from 31 patients with lung cancer treated with HT. RP was graded according to Common Terminology Criteria for Adverse Events version 4.0 and grade > or =2 RP was defined as a RP event. We used Kaplan-Meier methods to compute the actuarial incidence of RP. For univariate and multivariate analysis, the log-rank test and the Cox proportional regression hazard model were used. We generated receiver-operating characteristics (ROC) curves to define the cutoff values for significant parameters.
RESULTS
The median follow-up duration was 6.6 months (range, 1.6 to 38.5 months). The 2-, 4-, and 6-month actuarial RP event rates were 13.2%, 58.5%, and 67.0%, respectively. There was no grade 4 or more RP. Ipsilateral V5, V10, V15, and contralateral V5 were related with RP event on univariate analysis. By multivariate analysis, ipsilateral V10 was factor most strongly associated with RP event. On the ROC curve, the cutoff values of ipsilateral V5, V10, V15, and contralateral V5 were 67.5%, 58.5%, 50.0%, and 55.5%, respectively.
CONCLUSION
In our study, ipsilateral V5, V10, V15, and contralateral V5 were significant predictive factors for RP after HT.

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Predictive factors for severe radiation-induced lung injury in patients with lung cancer and coexisting interstitial lung disease
Shin-Hyung Park, Jae-Kwang Lim, Min Kyu Kang, Jongmoo Park, Chae Moon Hong, Chang Ho Kim, Seung Ick Cha, Jaehee Lee, Seoung-Jun Lee, Jae-Chul Kim
Radiotherapy and Oncology.2024; 192: 110053. CrossRef
Deep-Learning Model Prediction of Radiation Pneumonitis Using Pretreatment Chest Computed Tomography and Clinical Factors
Jang Hyung Lee, Min Kyu Kang, Jongmoo Park, Seoung-Jun Lee, Jae-Chul Kim, Shin-Hyung Park
Technology in Cancer Research & Treatment.2024;[Epub] CrossRef
Pulmonary toxicity of craniospinal irradiation using helical tomotherapy
Joongyo Lee, Euidam Kim, Nalee Kim, Chang-Ok Suh, Yoonsun Chung, Hong In Yoon
Scientific Reports.2022;[Epub] CrossRef
Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors
Xin Zhang, Dingyi Yang, Yong Jiang, Luo Huang, Can Wang, Dan Tao, Xianfeng Liu, Yongyang Lei, Yongzhong Wu, Wei Zhou
Journal of Inflammation Research.2021; Volume 14: 4205. CrossRef
The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer: A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study
Moonkyoo Kong, Seung Hyeun Lee, Jaehyo Kim, Beom-Joon Lee, Kwan-Il Kim
Integrative Cancer Therapies.2020;[Epub] CrossRef
Phase II study of compensator-based non-coplanar intensity-modulated radiotherapy for Stage I non–small-cell lung cancer
Tomohiro Itonaga, Ryuji Mikami, Hidetsugu Nakayama, Tatsuhiko Saito, Sachika Shiraishi, Mitsuru Okubo, Shinji Sugahara, Norihiko Ikeda, Koichi Tokuuye
Journal of Radiation Research.2019; 60(3): 387. CrossRef
Dosimetric Comparison Between Jaw Tracking and No Jaw Tracking in Intensity-Modulated Radiation Therapy
Shengyu Yao, Yin Zhang, Tingfeng Chen, Guoqi Zhao, Zhekai Hu, Xiaokai Lu, Yong Liu
Technology in Cancer Research & Treatment.2019;[Epub] CrossRef
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J Colnot, V Barraux, C Loiseau, P Berejny, A Batalla, R Gschwind, C Huet
Physics in Medicine & Biology.2019; 64(19): 195008. CrossRef
Treatment outcomes and patterns of radiologic appearance after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) for lung tumours
Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
The British Journal of Radiology.2017;[Epub] CrossRef
Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC
S Arcangeli, L Agolli, L Portalone, M R Migliorino, M G Lopergolo, A Monaco, J Dognini, M C Pressello, S Bracci, V Donato
The British Journal of Radiology.2015; 88(1048): 20140728. CrossRef
Early Toxicity in Patients Treated With Postoperative Proton Therapy for Locally Advanced Breast Cancer
John J. Cuaron, Brian Chon, Henry Tsai, Anuj Goenka, David DeBlois, Alice Ho, Simon Powell, Eugen Hug, Oren Cahlon
International Journal of Radiation Oncology*Biology*Physics.2015; 92(2): 284. CrossRef
Risk of radiation-induced pneumonitis after helical and static-port tomotherapy in lung cancer patients and experimental rats
Xianglan Zhang, You Keun Shin, Zhenlong Zheng, Lianhua Zhu, Ik Jae Lee
Radiation Oncology.2015;[Epub] CrossRef
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Ye Zhang, Yie Chen, Jie Qiu, Jack Yang
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.2014; 03(04): 252. CrossRef
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Journal of Applied Clinical Medical Physics.2014; 15(4): 105. CrossRef

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Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors: Moonkyoo Kong, Seong Eon Hong, Woo Suk Choi, Si-Young Kim, Jinhyun Choi; Cancer Res Treat. 2012;44(2):104-112. Published online June 30, 2012; DOI: https://doi.org/10.4143/crt.2012.44.2.104

Abstract PDF PubReader ePub

PURPOSE
This study was designed to investigate the long-term oncologic outcomes for locally advanced rectal cancer patients after treatment with preoperative concurrent chemoradiotherapy followed by total mesorectal excision, and to identify prognostic factors that affect survival and pathologic response.
MATERIALS AND METHODS
From June 1996 to June 2009, 135 patients with locally advanced rectal cancer were treated with preoperative concurrent chemoradiotherapy followed by total mesorectal excision at Kyung Hee University Hospital. Patient data was retrospectively collected and analyzed in order to determine the treatment outcomes and identify prognostic factors for survival.
RESULTS
The median follow-up time was 50 months (range, 4.5 to 157.8 months). After preoperative chemoradiotherapy, sphincter preservation surgery was accomplished in 67.4% of whole patients. A complete pathologic response was achieved in 16% of patients. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for all patients was 82.7% and 75.7%, 76.8% and 71.9%, 67.9% and 63.3%, respectively. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for pathologic complete responders was 100% and 100%, 100% and 88.9%, 95.5% and 95.5%, respectively. In the multivariate analysis, pathologic complete response was significantly associated with overall survival. The predictive factor for pathologic complete response was pretreatment clinical stage.
CONCLUSION
Preoperative chemoradiotherapy for locally advanced rectal cancer resulted in a high rate of overall survival, sphincter preservation, down-staging, and pathologic complete response. The patients achieving pathologic complete response had very favorable outcomes. Pathologic complete response was a significant prognostic factor for overall survival and the significant predictive factor for a pathologic complete response was pretreatment clinical stage.

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American Journal of Roentgenology.2016; 207(1): 32. CrossRef
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Tamir A. Hassan, Hossam M. Abdel-Rahman, Hala Yehia Ali
The Egyptian Journal of Radiology and Nuclear Medicine.2016; 47(4): 1243. CrossRef
Severe weight loss during preoperative chemoradiotherapy compromises survival outcome for patients with locally advanced rectal cancer
Junzhong Lin, Jianhong Peng, Aiham Qdaisat, Liren Li, Gong Chen, Zhenhai Lu, Xiaojun Wu, Yuanhong Gao, Zhifan Zeng, Peirong Ding, Zhizhong Pan
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Daniel G Couch
World Journal of Gastroenterology.2016; 22(2): 467. CrossRef
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Gennaro Galizia, Eva Lieto, Ferdinando De Vita, Francesca Ferraraccio, Anna Zamboli, Andrea Mabilia, Annamaria Auricchio, Paolo Castellano, Vincenzo Napolitano, Michele Orditura
International Journal of Colorectal Disease.2014; 29(1): 89. CrossRef
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Eine intensivierte Chemotherapie erhöht die Effektivität nicht, oder doch?
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