Cancer Research and Treatment

Original Articles

Lung cancer

Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase–Low Squamous Cell Lung Cancer: Mihong Choi, Heung Tae Kim, Ji-Youn Han, Geon Kook Lee, Soo-Hyun Lee, Kun Young Lim, Jungnam Joo, Hye Jin Won, Jin Soo Lee, Youngjoo Lee; Cancer Res Treat. 2021;53(1):87-92. Published online August 13, 2020; DOI: https://doi.org/10.4143/crt.2020.741

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Purpose
Squamous cell carcinomas (SqCC) of the lung often express high levels of thymidylate synthase (TS), which is associated with primary resistance to pemetrexed. We explored the efficacy of pemetrexed in a selected population of patients with lung SqCC with low TS expression.
Materials and Methods
In this single-arm phase II trial, we enrolled 32 previously-treated patients with advanced lung SqCC exhibiting low immunohistochemical staining for TS (i.e., in 10% or less of tumor cells). The primary endpoint was 12-week progression-free survival (PFS) rate.
Results
Of 32 patients, eight patients (25%) had an Eastern Cooperative Oncology Group performance status of 2, and seven patients (22%) had previously received three or more lines of chemotherapy. The disease control rate from pemetrexed treatment was 30%, and no objective response was observed. The 12-week PFS rate was 24.5% (95% confidence interval [CI], 13.0 to 46.1). Median PFS was 1.3 months (95% CI, 1.3 to 2.7), and median overall survival was 11.8 months (95% CI, 8.1 to not applicable). Most of adverse events were grade 1 or 2.
Conclusion
Pemetrexed demonstrated modest activity as a salvage chemotherapy in patients with advanced lung SqCC with low TS expression, although its toxicity was generally manageable.

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Bioengineered miR-7-5p modulates non–small cell lung cancer cell metabolism to improve therapy
Gavin M. Traber, Mei-Juan Tu, Su Guan, Neelu Batra, Ai-Ming Yu
Molecular Pharmacology.2025; 107(1): 100006. CrossRef

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Sequential Treatment with an Immune Checkpoint Inhibitor Followed by a Small-Molecule Targeted Agent Increases Drug-Induced Pneumonitis: Jongheon Jung, Hyae Young Kim, Dong-Gil Kim, Seog Yun Park, A Ra Ko, Ji-Youn Han, Heung Tae Kim, Jin Soo Lee, Youngjoo Lee; Cancer Res Treat. 2021;53(1):77-86. Published online August 6, 2020; DOI: https://doi.org/10.4143/crt.2020.543

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Purpose
Immune checkpoint inhibitors (ICI) and targeted small-molecule drugs are mainstay elements of lung cancer chemotherapy. However, they are associated with development of pneumonitis, a rare, but potentially life-threatening event. We analyzed lung cancer patients treated with ICI to evaluate the effect of sequential therapeutic administration on the incidence of pneumonitis.
Materials and Methods
In this retrospective study, 242 patients were included. Serial radiologic findings taken during and immediately after ICI treatment were reviewed. Factors that increased pneumonitis and the relationship between peri-ICI chemotherapy and the development of pneumonitis were evaluated.
Results
Pneumonitis developed in 23 patients (9.5%); severe pneumonitis (grade ≥ 3) occurred in 13 of 23 patients (56%); pneumonitis-related death occurred in six. High-dose thoracic radiation (≥ 6,000 cGy) revealed a tendency toward high risk of pneumonitis (odds ratio, 2.642; 95% confidence interval, 0.932 to 7.490; p=0.068). Among 149 patients followed for ≥ 8 weeks after the final ICI dose, more patients who received targeted agents within 8-weeks post-ICI experienced pneumonitis (3/16, 18.8%) compared with patients who received cytotoxic agents (4/54, 7.4%) or no chemotherapy (4/79, 5.1%) (p=0.162). Targeted therapy was associated with earlier-onset pneumonitis than treatment with cytotoxic agents (35 vs. 62 days post-ICI, p=0.007); the resulting pneumonitis was more severe (grade ≥ 3, 100% vs. 0%, p=0.031).
Conclusion
Sequential administration of small-molecule targeted agents immediately after ICI may increase the risk of severe pneumonitis. The sequence of chemotherapy regimens that include ICI and targeted agents should be carefully planned to reduce the risk of pneumonitis in lung cancer patients.

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Toxicities associated with sequential or combined use of immune checkpoint inhibitors and small targeted therapies in non-small cell lung cancer: A critical review of the literature
Anne-Laure Désage, Michael Duruisseaux, Claire Lafitte, Sophie Bayle-Bleuez, Christos Chouaid, Pierre Fournel, Thomas Pierret
Cancer Treatment Reviews.2024; 129: 102805. CrossRef
Deep learning for predicting the risk of immune checkpoint inhibitor-related pneumonitis in lung cancer
M. Cheng, R. Lin, N. Bai, Y. Zhang, H. Wang, M. Guo, X. Duan, J. Zheng, Z. Qiu, Y. Zhao
Clinical Radiology.2023; 78(5): e377. CrossRef
Evaluating Pneumonitis Incidence in Patients with Non–small Cell Lung Cancer Treated with Immunotherapy and/or Chemotherapy Using Real-world and Clinical Trial Data
Qi Liu, Chenan Zhang, Yue Huang, Ruihao Huang, Shiew-Mei Huang, Erin Larkins, Liza Stapleford, Donna R. Rivera, Paul G. Kluetz, Shenggang Wang, Hao Zhu, James Weese, Elizabeth Cromartie, Mahder Teka, Sheetal Walters, Frank Wolf, Thomas D. Brown
Cancer Research Communications.2023; 3(2): 258. CrossRef
Pulmonary toxicity in driver gene positive non-small cell lung cancer therapy
Yi-Pu Zhao, Yong Long
Current Medical Research and Opinion.2022; 38(8): 1369. CrossRef
Immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer: A review
Yuxuan Hao, Xiaoye Zhang, Li Yu
Frontiers in Oncology.2022;[Epub] CrossRef
Improving Time-to-Treatment for Advanced Non-Small Cell Lung Cancer Patients through Faster Single Gene EGFR Testing Using the Idylla™ EGFR Testing Platform
Norbert Banyi, Deepu Alex, Curtis Hughesman, Kelly McNeil, Diana N. Ionescu, Carmen Ma, Stephen Yip, Barbara Melosky
Current Oncology.2022; 29(10): 7900. CrossRef
Sequential or combined immune checkpoint inhibitors and targeted therapy: Navigating uncharted waters
K. El Husseini, M. Wislez
Respiratory Medicine and Research.2021; 79: 100820. CrossRef
Multiple drugs

Reactions Weekly.2021; 1863(1): 255. CrossRef
Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
Jeong Hun Kim, Won Suk Lee, Hye Jin Lee, Hannah Yang, Seung Joon Lee, So Jung Kong, Soyeon Je, Hyun-Jin Yang, Jongsun Jung, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim
OncoImmunology.2021;[Epub] CrossRef

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Real-World Experience of Nivolumab in Non-small Cell Lung Cancer in Korea: Sun Min Lim, Sang-We Kim, Byoung Chul Cho, Jin Hyung Kang, Myung-Ju Ahn, Dong-Wan Kim, Young-Chul Kim, Jin Soo Lee, Jong-Seok Lee, Sung Yong Lee, Keon Uk Park, Ho Jung An, Eun Kyung Cho, Tae Won Jang, Bong-Seog Kim, Joo-Hang Kim, Sung Sook Lee, Im-II Na, Seung Soo Yoo, Ki Hyeong Lee; Cancer Res Treat. 2020;52(4):1112-1119. Published online May 15, 2020; DOI: https://doi.org/10.4143/crt.2020.245

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Purpose
The introduction of immune checkpoint inhibitors represents a major advance in the treatment of lung cancer, allowing sustained recovery in a significant proportion of patients. Nivolumab is a monoclonal anti–programmed death cell protein 1 antibody licensed for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. In this study, we describe the demographic and clinical outcomes of patients with advanced NSCLC treated with nivolumab in the Korean expanded access program.
Materials and Methods
Previously treated patients with advanced non-squamous and squamous NSCLC patients received nivolumab at 3 mg/kg every 2 weeks up to 36 months. Efficacy data including investigator-assessed tumor response, progression data, survival, and safety data were collected.
Results
Two hundred ninety-nine patients were treated across 36 Korean centers. The objective response rate and disease control rate were 18% and 49%, respectively; the median progression-free survival was 2.1 months (95% confidence interval [CI], 1.87 to 3.45), and the overall survival (OS) was 13.2 months (95% CI, 10.6 to 18.9). Patients with smoking history and patients who experienced immune-related adverse events showed a prolonged OS. Cox regression analysis identified smoking history, presence of immune-related adverse events as positive factors associated with OS, while liver metastasis was a negative factor associated with OS. The safety profile was generally comparable to previously reported data.
Conclusion
This real-world analysis supports the use of nivolumab for pretreated NSCLC patients, including those with an older age.

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Advances in reprogramming of energy metabolism in tumor T cells
Liu Xuekai, Song Yan, Chu Jian, Song Yifei, Wu Xinyue, Zhang Wenyuan, Han Shuwen, Yang Xi
Frontiers in Immunology.2024;[Epub] CrossRef
Effectiveness and Safety of PD-1 Inhibitors’ Treatment for Patients with Non-Small-Cell Lung Cancer in China: A Real-World Study
Ning Wan, Yongbang Chen, Liqing Lu, Bing Wang, Liuliu He, Hongyi Liang, Fei Xie, Xiaoshun Jian, Bo Ji, Jianping Zhang, Hammoda Abu-Odah
European Journal of Cancer Care.2024; 2024: 1. CrossRef
Optimization of treatment strategies for elderly patients with advanced non-small cell lung cancer
Qiang Chen, Shuo Ying, Jianwen Qin, Li Zhang
Frontiers in Oncology.2024;[Epub] CrossRef
Real-World Data on Pembrolizumab for Pretreated Non-Small-Cell Lung Cancer: Clinical Outcome and Relevance of the Lung Immune Prognostic Index
Ana Ortega-Franco, Clare Hodgson, Haseem Raja, Mathew Carter, Colin Lindsay, Sarah Hughes, Laura Cove-Smith, Paul Taylor, Yvonne Summers, Fiona Blackhall, Raffaele Califano
Targeted Oncology.2022; 17(4): 453. CrossRef
Liver metastases and the efficacy of immune checkpoint inhibitors in advanced lung cancer: A systematic review and meta-analysis
Handai Xia, Wengang Zhang, Yuqing Zhang, Xiaoling Shang, Yanguo Liu, Xiuwen Wang
Frontiers in Oncology.2022;[Epub] CrossRef
Immune-Related Adverse Events Predict the Efficacy of Immune Checkpoint Inhibitors in Lung Cancer Patients: A Meta-Analysis
Donghui Wang, Cen Chen, Yanli Gu, Wanjun Lu, Ping Zhan, Hongbing Liu, Tangfeng Lv, Yong Song, Fang Zhang
Frontiers in Oncology.2021;[Epub] CrossRef
Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer
Min Jung Geum, Chungsoo Kim, Ji Eun Kang, Jae Hee Choi, Jae Song Kim, Eun Sun Son, Sun Min Lim, Sandy Jeong Rhie
Pharmaceuticals.2021; 14(5): 445. CrossRef
Nivolumab

Reactions Weekly.2021; 1855(1): 269. CrossRef
Immune-Related Adverse Events Associated With Outcomes in Patients With NSCLC Treated With Anti-PD-1 Inhibitors: A Systematic Review and Meta-Analysis
Zhe Zhao, Xinfeng Wang, Jinghan Qu, Wei Zuo, Yan Tang, Huijuan Zhu, Xiaoguang Chen
Frontiers in Oncology.2021;[Epub] CrossRef

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Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Re-biopsy in Previously Treated Lung Cancer: Joohae Kim, Hyo Jae Kang, Sung Ho Moon, Jong Mog Lee, Hyae Young Kim, Geon-Kook Lee, Jin Soo Lee, Bin Hwangbo; Cancer Res Treat. 2019;51(4):1488-1499. Published online March 15, 2019; DOI: https://doi.org/10.4143/crt.2019.031

Abstract PDF Supplementary Material PubReader ePub

Purpose
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used for the diagnosis and staging of lung cancer. However, evidence of its usefulness for re-biopsy in treated lung cancer, especially according to the previous treatment, is limited. We evaluated the role of EBUS-TBNA for re-biopsy and its diagnostic values in patients with different treatment histories.
Materials and Methods
We reviewed the medical records of patients who underwent EBUS-TBNA for re-biopsy of suspicious recurrent or progressive lesions between January 2006 and December 2016 at the National Cancer Center in South Korea. Patients were categorized into three groups based on the previous treatment modalities: surgery, radiation, and palliation.
Results
Among the 367 patients (surgery, n=192; radiation, n=40; palliation, n=135) who underwent EBUS-TBNA for re-biopsy, the overall sensitivity, negative predictive value (NPV), and diagnostic accuracy of EBUS-TBNA in detecting malignancy were 95.6%, 82.7%, and 96.3%, respectively. The sensitivity was lower in the radiation group (83.3%) when compared with the surgery (95.7%, p=0.042) and palliation (97.7%, p=0.012) groups. The NPV was lower in the palliation group (50.0%) than in the surgery group (88.5%, p=0.042). The sample adequacy of EBUS-TBNA specimens was lower in the radiation group (80.3%) than in the surgery (95.4%, p < 0.001) or palliation (97.8%, p < 0.001) groups. EGFR mutation analysis was feasible in 94.6% of the 92 cases, in which mutation analysis was requested. There were no major complications. Minor complications were reported in 12 patients (3.3%).
Conclusion
EBUS-TBNA showed high diagnostic values and high suitability for EGFR mutation analysis with regard to re-biopsy in patients with previously treated lung cancer. The sensitivity was lower in the radiation group and NPV was lower in the palliation group. The complication rate was low.

Citations

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Repeat biopsy versus initial biopsy in terms of complication risk factors and clinical outcomes for patients with non-small cell lung cancer: a comparative study of 113 CT-guided needle biopsy of lung lesions
Yangyang Wang, Yongyuan Zhang, Nana Ren, Fangting Li, Lin Lu, Xin Zhao, Zhigang Zhou, Mengyu Gao, Meng Wang
Frontiers in Oncology.2024;[Epub] CrossRef
Artificial Intelligence Algorithm Can Predict Lymph Node Malignancy from Endobronchial Ultrasound Transbronchial Needle Aspiration Images for Non-Small Cell Lung Cancer
Yogita S. Patel, Anthony A. Gatti, Forough Farrokhyar, Feng Xie, Waël C. Hanna
Respiration.2024; : 1. CrossRef
Place de l’endoscopie dans l’exploration du médiastin, indications et résultats
F. Wallyn, C. Fournier, V. Jounieaux, D. Basille
Revue des Maladies Respiratoires.2023; 40(1): 78. CrossRef
Prognostic Impact of EBUS TBNA for Lung Adenocarcinoma Patients with Postoperative Recurrences
Ying-Yi Chen, Ying-Shian Chen, Tsai-Wang Huang
Diagnostics.2022; 12(10): 2547. CrossRef
Endobronchial ultrasound-guided transbronchial needle aspiration in patients with previously treated malignancies: diagnostic performance and predictive value
Yan Yan, Zhilong Wang, Wanpu Yan, Shijie Li, Qi Wu
BMC Pulmonary Medicine.2022;[Epub] CrossRef
The Feasibility of Interventional Pulmonology Methods for Detecting the T790M Mutation after the First or Second-Generation EGFR-TKI Resistance of Non-Small Cell Lung Cancer
Wen-Chien Cheng, Yi-Cheng Shen, Chieh-Lung Chen, Wei-Chih Liao, Hung-Jen Chen, Te-Chun Hsia, Chia-Hung Chen, Chih-Yen Tu
Diagnostics.2022; 13(1): 129. CrossRef
Impact of EBUS-TBNA in addition to [18F]FDG-PET/CT imaging on target volume definition for radiochemotherapy in stage III NSCLC
Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Till Ploenes, Christoph Pöttgen, Nika Guberina, Ken Herrmann, Lale Umutlu, Axel Wetter, Dirk Theegarten, Clemens Aigner, Wilfried Ernst Erich Eberhardt, Martin Schuler, Rüdiger Karpf-Wissel, Martin Stuschke
European Journal of Nuclear Medicine and Molecular Imaging.2021; 48(9): 2894. CrossRef
Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis
Bo Da Nam, Soon Ho Yoon, Hyunsook Hong, Jung Hwa Hwang, Jin Mo Goo, Suyeon Park
Korean Journal of Radiology.2021; 22(12): 2082. CrossRef

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WITHDRAWN:The Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Re-biopsy in Previously Treated Lung Cancer: Joohae Kim, Hyo Jae Kang, Sung Ho Moon, Jong Mog Lee, Hyae Young Kim, Geon-Kook Lee, Jin Soo Lee, Bin Hwangbo; Received April 16, 2018 Accepted August 21, 2018 Published online September 3, 2018; DOI: https://doi.org/10.4143/crt.2018.222 [Accepted]

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Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up: Hyae Young Kim, Kyu-Won Jung, Kun Young Lim, Soo-Hyun Lee, Jae Kwan Jun, Jeongseon Kim, Bin Hwangbo, Jin Soo Lee; Cancer Res Treat. 2018;50(3):748-756. Published online July 17, 2017; DOI: https://doi.org/10.4143/crt.2017.312

Abstract PDF Supplementary Material PubReader ePub

Purpose
Because of growing concerns about lung cancer in female never smokers, chest low-dose computed tomography (LDCT) screening is often performed although it has never shown clinical benefits. We examinewhether or not female never smokers really need annual LDCT screening when the initial LDCT showed negative findings.
Materials and Methods
This retrospective cohort study included 4,365 female never smokers aged 40 to 79 years who performed initial LDCT from Aug 2002 to Dec 2007. Lung cancer diagnosis was identified from the Korea Central Cancer Registry Database registered until December 31, 2013. We calculated the incidence, cumulative probability, and standardized incidence ratio (SIR) of lung cancer by Lung Imaging Reporting and Data System (Lung-RADS) categories showed on initial LDCT.
Results
After median follow-up of 9.69 years, 22 (0.5%) had lung cancer. Lung cancer incidence for Lung-RADS category 4 was 1,848.4 (95% confidence interval [CI], 1,132.4 to 3,017.2) per 100,000 person-years and 16.4 (95% CI, 7.4 to 36.4) for categories 1, 2, and 3 combined. The cumulative probability of lung cancer for category 4 was 10.6% at 5 years and 14.8% at 10 years while they were 0.07% and 0.17% when categories 1, 2, and 3 were combined. The SIR for subjects with category 4 was 43.80 (95% CI, 25.03 to 71.14), which was much higher than 0.47 (95% CI, 0.17 to 1.02) for categories 1, 2, and 3 combined.
Conclusion
Considering the low risk of lung cancer development in female never smokers, it seems unnecessary to repeat annual LDCT screening for at least 5 years or even longer unless the initial LDCT showed Lung-RADS category 4 findings.

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Lung cancer screening for never smokers: current evidence and future directions
Kay Choong See
Singapore Medical Journal.2024;[Epub] CrossRef
Cooking oil fume exposure and Lung-RADS distribution among school cafeteria workers of South Korea
Minjun Kim, Yangho Kim, A Ram Kim, Woon Jung Kwon, Soyeoun Lim, Woojin Kim, Cheolin Yoo
Annals of Occupational and Environmental Medicine.2024;[Epub] CrossRef
Distribution of Solid Lung Nodules Presence and Size by Age and Sex in a Northern European Nonsmoking Population
Jiali Cai, Marleen Vonder, Gert Jan Pelgrim, Mieneke Rook, Gerdien Kramer, Harry J.M. Groen, Geertruida H. de Bock, Rozemarijn Vliegenthart, Albert de Roos
Radiology.2024;[Epub] CrossRef
Low Dose Computed Tomography for Lung Cancer Screening in Tuberculosis Endemic Countries: A Systematic Review and Meta-Analysis
Vikram Damaraju, Juhu Kiran Krushna Karri, Gayathri Gandrakota, Yamini Marimuthu, Adimulam Ganga Ravindra, Rajeev Aravindakshan, Navneet Singh
Journal of Thoracic Oncology.2024;[Epub] CrossRef
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Fu-Zong Wu, Yeun-Chung Chang
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Kim L. Sandler, Travis S. Henry, Arya Amini, Saeed Elojeimy, Aine Marie Kelly, Christopher T. Kuzniewski, Elizabeth Lee, Maria D. Martin, Michael F. Morris, Neeraja B. Peterson, Constantine A. Raptis, Gerard A. Silvestri, Arlene Sirajuddin, Betty C. Tong,
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Yifei Mao, Jiali Cai, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Matthijs Oudkerk, Marleen Vonder, Monique D. Dorrius, Geertruida H. de Bock
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Po-Chih Chang, Shah-Hwa Chou, Che-Yu Chuang, I-Hsiao Yang, Yu-Wei Liu, Ming-Cheng Shi, Reu-Sheng Sheu, Ting-Wei Chang
Formosan Journal of Surgery.2022; 55(3): 102. CrossRef
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Maurizio V. Infante, Giuseppe Cardillo
European Respiratory Journal.2020; 56(5): 2002949. CrossRef
Low-dose chest computed tomographic screening and invasive diagnosis of pulmonary nodules for lung cancer in never-smokers
Yeon Wook Kim, Hye-Rin Kang, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
European Respiratory Journal.2020; 56(5): 2000177. CrossRef
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Li-Hsin Chien, Chung-Hsing Chen, Tzu-Yu Chen, Gee-Chen Chang, Ying-Huang Tsai, Chin-Fu Hsiao, Kuan-Yu Chen, Wu-Chou Su, Wen-Chang Wang, Ming-Shyan Huang, Yuh-Min Chen, Chih-Yi Chen, Sheng-Kai Liang, Chung-Yu Chen, Chih-Liang Wang, Mei-Hsuan Lee, Ren-Hua C
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(2): 452. CrossRef
Role of Low-Dose Computerized Tomography in Lung Cancer Screening among Never-Smokers
Hye-Rin Kang, Jun Yeun Cho, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
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Haval Balata, Kwun M. Fong, Lizza E. Hendriks, Stephen Lam, Jamie S. Ostroff, Nir Peled, Ning Wu, Charu Aggarwal
Journal of Thoracic Oncology.2019; 14(9): 1513. CrossRef

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Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer: Youngjoo Lee, Ki Hyeong Lee, Geon Kook Lee, Soo-Hyun Lee, Kun Young Lim, Jungnam Joo, Yun Jung Go, Jin Soo Lee, Ji-Youn Han; Cancer Res Treat. 2017;49(4):1001-1011. Published online January 13, 2017; DOI: https://doi.org/10.4143/crt.2016.546

Abstract PDF PubReader ePub

Purpose
This phase II study examined whether the addition of simvastatin to afatinib provides a clinical benefit compared with afatinib monotherapy in previously treated patients with nonadenocarcinomatous non-small cell lung cancer (NA-NSCLC).
Materials and Methods
Patientswith advancedNA-NSCLCwho progressed after one ortwo chemotherapy regimens were randomly assigned to a simvastatin (40 mg/day) plus afatinib (40 mg/day) (AS) arm or to an afatinib (A) arm. The primary endpoint was response rate (RR).
Results
Sixty-eight patients were enrolled (36 in the AS arm and 32 in the A arm). The RR was 5.7% (95% confidence interval [CI], 0.7 to 19.2) for AS and 9.4% (95% CI, 2.0 to 25.0) for A (p=0.440). In arms AS and A, the median progression-free survival (PFS) was 1.0 versus 3.6 months (p=0.240) and the overall survival was 10.0 months versus 7.0 months (p=0.930), respectively. Skin rash, stomatitis, and diarrhea were the most common adverse events in both arms. More grade 3 or 4 diarrhea was observed in arm A (18.8% vs. 5.6% in arm AS). In all patients, the median PFS for treatment including afatinib was not correlated with the status of epidermal growth factor receptor (EGFR) mutation (p=0.122), EGFR fluorescence in situ hybridization (p=0.944), or EGFR immunohistochemistry (p=0.976). However, skin rash severity was significantly related to the risk of progression for afatinib (hazard ratio for skin rash grade ≥ 2 vs. grade < 2, 0.44; 95% CI, 0.25 to 0.78; p=0.005).
Conclusion
There were no significant differences in the efficacy between AS and A arms in patients with NA-NSCLC.

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Incorporating Erlotinib or Irinotecan Plus Cisplatin into Chemoradiotherapy for Stage III Non-small Cell Lung Cancer According to EGFR Mutation Status: Youngjoo Lee, Ji-Youn Han, Sung Ho Moon, Byung-Ho Nam, Kun Young Lim, Geon Kook Lee, Heung Tae Kim, Tak Yun, Hye Jin An, Jin Soo Lee; Cancer Res Treat. 2017;49(4):981-989. Published online January 6, 2017; DOI: https://doi.org/10.4143/crt.2016.522

Abstract PDF Supplementary Material PubReader ePub

Purpose
Concurrent chemoradiotherapy (CCRT) is the standard care for stage III non-small cell lung cancer (NSCLC) patients; however, a more effective regimen is needed to improve the outcome by better controlling occult metastases. We conducted two parallel randomized phase II studies to incorporate erlotinib or irinotecan-cisplatin (IP) into CCRT for stage III NSCLC depending on epidermal growth factor receptor (EGFR) mutation status.
Materials and Methods
Patients with EGFR-mutant tumors were randomized to receive three cycles of erlotinib first and then either CCRT with erlotinib followed by erlotinib (arm A) or CCRT with IP only (arm B). Patients with EGFR unknown or wild-type tumors were randomized to receive either three cycles of IP before (arm C) or after CCRT with IP (arm D).
Results
Seventy-three patients were screened and the study was closed early because of slow accrual after 59 patients were randomized. Overall, there were seven patients in arm A, five in arm B, 22 in arm C, and 25 in arm D. The response rate was 71.4% and 80.0% for arm A and B, and 70.0% and 73.9% for arm C and D. The median overall survival (OS) was 39.3 months versus 31.2 months for arm A and B (p=0.442), and 16.3 months versus 25.3 months for arm C and D (p=0.050). Patients with sensitive EGFR mutations had significantly longer OS than EGFR-wild patients (74.8 months vs. 25.3 months, p=0.034). There were no unexpected toxicities.
Conclusion
Combined-modality treatment by molecular diagnostics is feasible in stage III NSCLC. EGFR-mutant patients appear to be a distinct subset with longer survival.

Citations

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Targeted treatment for unresectable EGFR mutation-positive stage III non-small cell lung cancer: Emerging evidence and future perspectives
Terufumi Kato, Ignacio Casarini, Manuel Cobo, Corinne Faivre-Finn, Fiona Hegi-Johnson, Shun Lu, Mustafa Özgüroğlu, Suresh S. Ramalingam
Lung Cancer.2024; 187: 107414. CrossRef
The ASCENT Trial: a phase 2 study of induction and consolidation afatinib and chemoradiation with or without surgery in stage III EGFR-mutant NSCLC
Allison E B Chang, Andrew J Piper-Vallillo, Raymond H Mak, Michael Lanuti, Alona Muzikansky, Julia Rotow, Pasi A Jänne, Mari Mino-Kenudson, Scott Swanson, Cameron D Wright, David Kozono, Paul Marcoux, Zofia Piotrowska, Lecia V Sequist, Henning Willers
The Oncologist.2024; 29(7): 609. CrossRef
Management of Non-Metastatic Non-Small Cell Lung Cancer (NSCLC) with Driver Gene Alterations: An Evolving Scenario
Valeria Fuorivia, Ilaria Attili, Carla Corvaja, Riccardo Asnaghi, Ambra Carnevale Schianca, Pamela Trillo Aliaga, Ester Del Signore, Gianluca Spitaleri, Antonio Passaro, Filippo de Marinis
Current Oncology.2024; 31(9): 5121. CrossRef
Comparison of treatment regimens for unresectable stage III epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer
Xin Dai, Qian Xu, Lei Sheng, Xue Zhang, Miao Huang, Song Li, Kai Huang, Jiahui Chu, Jian Wang, Jisheng Li, Yanguo Liu, Jianyuan Zhou, Shulun Nie, Lian Liu
Chinese Medical Journal.2024;[Epub] CrossRef
Management of Oncogene Driven Locally Advanced Unresectable Non-small Cell Lung Cancer
Jerold Loh, Jia Li Low, Manavi Sachdeva, Peter QJ Low, Rachel Su Jen Wong, Yiqing Huang, Puey Ling Chia, Ross A Soo
Expert Review of Anticancer Therapy.2023; 23(9): 913. CrossRef
Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery
Farid Hajareh Haghighi, Roya Binaymotlagh, Ilaria Fratoddi, Laura Chronopoulou, Cleofe Palocci
Gels.2023; 9(12): 953. CrossRef
Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1‐STAT1 loop in lung adenocarcinoma
Wei‐Chao Liao, Tsung‐Jen Lin, Yu‐Chin Liu, Yu‐Shan Wei, Guan‐Ying Chen, Hsiang‐Pu Feng, Yi‐Feng Chang, Hsin‐Tzu Chang, Chih‐Liang Wang, Hsinag‐Cheng Chi, Chun‐I Wang, Kwang‐Huei Lin, Wei‐Ting Ou Yang, Chia‐Jung Yu
Cancer Science.2022; 113(1): 205. CrossRef
Erlotinib Versus Etoposide/Cisplatin With Radiation Therapy in Unresectable Stage III Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Multicenter, Randomized, Open-Label, Phase 2 Trial
Ligang Xing, Gang Wu, Luhua Wang, Jiancheng Li, Jianhua Wang, Zhiyong Yuan, Ming Chen, Yaping Xu, Xiaolong Fu, Zhengfei Zhu, You Lu, Chun Han, Tingyi Xia, Conghua Xie, Guang Li, Shenglin Ma, Bing Lu, Qin Lin, Guangying Zhu, Baolin Qu, Wanqi Zhu, Jinming Y
International Journal of Radiation Oncology*Biology*Physics.2021; 109(5): 1349. CrossRef
A systematic review and meta-analysis of treatment-related toxicities of curative and palliative radiation therapy in non-small cell lung cancer
M. Or, B. Liu, J. Lam, S. Vinod, W. Xuan, R. Yeghiaian-Alvandi, E. Hau
Scientific Reports.2021;[Epub] CrossRef
Tyrosine Kinase Inhibitor Therapy in Unresectable Locally Advanced NSCLC: Keep Holding Our Breaths or Time to Take a Breather?
Aruz Mesci, Theodoros Tsakiridis, Anand Swaminath
Journal of Thoracic Oncology.2021; 16(10): 1607. CrossRef
Experiences of patients with lung cancer receiving concurrent chemo-radiotherapy
Choi Eunsook, Park Sunhee
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Recent advances and new insights in the management of early-stage epidermal growth factor receptor-mutated non-small-cell lung cancer
Miguel J Sotelo, José Luis García, Cesar Torres-Mattos, Héctor Milián, Carlos Carracedo, María Ángeles González-Ruiz, Xabier Mielgo-Rubio, Juan Carlos Trujillo-Reyes, Felipe Couñago
World Journal of Clinical Oncology.2021; 12(10): 912. CrossRef
PLGA nanoparticle-reinforced supramolecular peptide hydrogels for local delivery of multiple drugs with enhanced synergism
Can Wu, Chunlu Wang, Lu Sun, Keming Xu, Wenying Zhong
Soft Matter.2020; 16(46): 10528. CrossRef
Epidermal growth factor receptor tyrosine kinase inhibitors combined with thoracic radiotherapy or chemoradiotherapy for advanced or metastatic non-small cell lung cancer: A systematic review and meta-analysis of single-arm trials
Ruifeng Liu, Shihong Wei, Qiuning Zhang, Xueliang Zhang, Hongtao Luo, Jinhui Tian, Yi Li, Long Ge, Xiaohu Wang
Medicine.2019; 98(29): e16427. CrossRef
Role of Anti-EGFR Targeted Therapies in Stage III Locally Advanced Non-small Cell Lung Cancer: Give or Not to Give?
Sanjal Desai, Chul Kim, Irina Veytsman
Current Oncology Reports.2019;[Epub] CrossRef

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ERCC1 Expression-Based Randomized Phase II Study of Gemcitabine/Cisplatin Versus Irinotecan/Cisplatin in Patients with Advanced Non-small Cell Lung Cancer: Ji-Youn Han, Geon Kook Lee, Kun Young Lim, Young Ju Lee, Byung Ho Nam, Jin Soo Lee; Cancer Res Treat. 2017;49(3):678-687. Published online October 11, 2016; DOI: https://doi.org/10.4143/crt.2016.365

Abstract PDF Supplementary Material PubReader ePub

Purpose
We evaluated the clinical utility of excision repair cross-complementation group 1 (ERCC1) expression as a predictive biomarker for platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC).
Materials and Methods
Eligible patients were randomly assigned to the GP (gemcitabine 1,250 mg/m² on days 1 and 8, and cisplatin 75 mg/m² on day 1 every 3 weeks) or IP (irinotecan 65 mg/m² and cisplatin 30 mg/m² on days 1 and 8 every 3 weeks) arm. The primary goal of this study was to compare the response rate (RR) of the GP and IP arms according to the ERCC1 expression level.
Results
A total of 279 patients were randomly assigned to the GP (n=139) and IP (n=140) arms, among which 63% were ERCC1-positive and 268 patients were assessable for the RR. The GP and IP arms did not differ significantly with respect to the RR (29.8% vs. 27.0%, respectively; p=0.082), median progression-free survival (PFS; 4.5 months vs. 3.9 months, respectively; p=0.117), and overall survival (OS; 16.5 months vs. 16.7 months, respectively; p=0.313). When comparing the efficacy between the ERCC1-positive and ERCC1-negative groups, there was no significant difference in the RR (GP, 28.2% vs. 32.6%, respectively, p=0.509; IP, 30.2% vs. 21.6%, respectively, p=0.536), median PFS (GP, 4.6 months vs. 5.0 months, respectively, p=0.506; IP, 3.9 months vs. 3.7 months, respectively, p=0.748), or median OS (GP, 18.6 months vs. 11.9 months, respectively, p=0.070; IP, 17.5 months vs. 14.0 months, respectively, p=0.821).
Conclusion
Immunohistochemical analysis of the ERCC1 expression level did not differentiate the efficacy of platinum-based chemotherapy in advanced NSCLC.

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Meta‐Analysis of ERCC1 Protein Expression and Platinum Chemosensitivity in Non‐Small‐Cell Lung Cancer
Guoping Li, Dan Cheng, Jamal A. Mahajna
Evidence-Based Complementary and Alternative Medicine.2020;[Epub] CrossRef
The role of ERCC1 and AFP gene polymorphism in hepatocellular carcinoma
Yu-Liang Huang, Jun-Rong Wu, Min Fang, Hui-Liu Zhao, Zhi-Min Liu, Jian Ye, Ling-Sha Huang, Bo Zhu
Medicine.2019; 98(14): e15090. CrossRef

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A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma Who Have Acquired Resistance to EGFR–Tyrosine Kinase Inhibitors: Ji-Youn Han, Ki Hyeong Lee, Sang-We Kim, Young Joo Min, Eunkyung Cho, Youngjoo Lee, Soo-Hyun Lee, Hyae Young Kim, Geon Kook Lee, Byung Ho Nam, Hyesun Han, Jina Jung, Jin Soo Lee; Cancer Res Treat. 2017;49(1):10-19. Published online May 3, 2016; DOI: https://doi.org/10.4143/crt.2016.058

Abstract PDF Supplementary Material PubReader ePub

Purpose
We examined the efficacy of poziotinib, a second-generation epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) in patients with lung adenocarcinoma with activating EGFR mutations, who developed acquired resistance (AR) to EGFR-TKIs.
Materials and Methods
This single-arm phase II study included EGFR-mutant lung adenocarcinoma with AR to erlotinib or gefitinib based on the Jackman criteria. Patients received poziotinib 16 mg orally once daily in a 28-day cycle. The primary endpoint was progression-free survival (PFS). Prestudy tumor biopsies and blood samples were obtained to determine resistance mechanisms.
Results
Thirty-nine patients were treated. Tumor genotyping was determined in 37 patients; 19 EGFR T790M mutations and two PIK3CAmutations were detected in the prestudy tumors, and seven T790M mutations were detected in the plasma assay. Three (8%; 95% confidence interval [CI], 2 to 21) and 17 (44%; 95% CI, 28 to 60) patients had partial response and stable disease, respectively. The median PFS and overall survival were 2.7 months (95% CI, 1.8 to 3.7) and 15.0 months (95% CI, 9.5 to not estimable), respectively. A longer PFS was observed for patients without T790M or PIK3CA mutations in tumor or plasma compared to those with these mutations (5.5 months vs. 1.8 months, p=0.003). The most frequent grade 3 adverse events were rash (59%), mucosal inflammation (26%), and stomatitis (18%). Most patients required one (n=15) or two (n=15) dose reductions.
Conclusion
Low activity of poziotinib was detected in patients with EGFR-mutant non-small cell lung cancer who developed AR to gefitinib or erlotinib, potentially because of severe-toxicityimposed dose limitation.

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A Phase II Study of Weekly Paclitaxel Plus Gemcitabine as a Second-Line Therapy in Patients with Metastatic or Recurrent Small Cell Lung Cancer: Tak Yun, Heung Tae Kim, Ji-Youn Han, Sung Jin Yoon, Hyae Young Kim, Byung-Ho Nam, Jin Soo Lee; Cancer Res Treat. 2016;48(2):465-472. Published online May 26, 2015; DOI: https://doi.org/10.4143/crt.2015.061

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Purpose
Paclitaxel (P) and gemcitabine (G) are clinically synergistic in small cell lung cancer (SCLC). We evaluated the efficacy of PG as a salvage treatment for SCLC patients whose disease progressed after a platinum-containing regimen.
Materials and Methods
Eligibility included histologically confirmed SCLC, one dimensionally measurable disease, Eastern Cooperative Oncology Group performance status 0-2, and progressive disease after platinum-based chemotherapy. Treatment consisted of P (80 mg/m2) and G (1,000 mg/m2) on days 1 and 8 of each cycle of 21 days until disease progression.
Results
Thirty-three patients seen between December 2005 and February 2009 were selected into this study. Thirty patients (91%) had received irinotecan-platinum, and three had received etoposide-platinum. Sixteen patients (49%) had a treatment-free interval of less than 3 months. The overall response rate was 30.3% (29.4% in sensitive relapse and 31.3% in refractory relapse). The median time to progression was 12.0 weeks and median overall survival (OS) 31.0 weeks, with a 1-year OS rate of 30.3%. Toxicities were moderate and manageable with 18.2% grade (G) 4 neutropenia, 24.2% G3 thrombocytopenia, 6.1% G3 sensory neuropathy, and 3% G3 asthenia. One patient developed febrile neutropenia.
Conclusion
Second-line paclitaxel and gemcitabine were well-tolerated and moderately active in SCLC patients previously treated with platinum-based chemotherapy.

Citations

Citations to this article as recorded by

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Special Articles

Prediction of Cancer Incidence and Mortality in Korea, 2014: Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Duk Hyoung Lee, Jin Soo Lee; Cancer Res Treat. 2014;46(2):124-130. Published online April 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.2.124

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Purpose

We studied and reported on cancer incidence and mortality rates as projected for the year 2014 in order to estimate Korea's current cancer burden.

Materials and Methods

Cancer incidence data from 1999 to 2011 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2012 were acquired from Statistics Korea. Cancer incidence in 2014 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. For cancer mortality, a similar procedure was employed, except that a Joinpoint regression model was used to determine at which year the linear trend changed significantly.

Results

A total of 265,813 new cancer cases and 74,981 cancer deaths are expected to occur in Korea in 2014. Further, the crude incidence rate per 100,000 of all sites combined will likely reach 524.7 and the age-standardized incidence rate, 338.5. Meanwhile, the crude mortality rate of all sites combined and age-standardized rate are projected to be 148.0 and 84.6, respectively. Given the rapid rise in prostate cancer cases, it is anticipated to be the fourth most frequently occurring cancer site in men for the first time.

Conclusion

Cancer has become the most prominent public health concern in Korea, and as the population ages, the nation's cancer burden will continue to increase.

Citations

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103 Download
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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011: Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Duk Hyoung Lee, Jin Soo Lee; Cancer Res Treat. 2014;46(2):109-123. Published online April 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.2.109

Abstract PDF PubReader ePub

Purpose

This study aimed to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends.

Materials and Methods

Incidence data from 1993 to 2011 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2012. Mortality data from 1983 to 2011 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated.

Results

A total of 218,017 cancer cases and 71,579 cancer deaths were reported to have occurred in 2011, and there were 1,097,253 prevalent cases identified in Korea as of January 1, 2012. Over the past 13 years (1999-2011), overall incidence rates have increased by 3.4% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, thyroid cancer increased by 23.3% per year in both sexes, and became the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2011. Five-year relative survival rates of patients diagnosed in the last 5 years (2007-2011) have improved by 25.1% compared with those from 1993 to 1995.

Conclusion

Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased rapidly and survival has improved.

Citations

Citations to this article as recorded by

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Clinical Endocrinology.2016; 84(2): 257. CrossRef
A Case of von Hippel–Lindau Disease with Colorectal Adenocarcinoma, Renal Cell Carcinoma and Hemangioblastomas
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Cancer Research and Treatment.2016; 48(1): 409. CrossRef
Cancer literacy as a mediator for cancer screening behaviour in Korean adults
Hee Yun Lee, Taeho Greg Rhee, Nam Keol Kim
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Postoperative Lower Extremity Edema in Patients with Primary Endometrial Cancer
Hyo Sook Bae, Myong Cheol Lim, Jeong Seon Lee, Yumi Lee, Byung Ho Nam, Sang-Soo Seo, Sokbom Kang, Seung Hyun Chung, Joo-Young Kim, Sang-Yoon Park
Annals of Surgical Oncology.2016; 23(1): 186. CrossRef
Trends in Cancer Screening Rates among Korean Men and Women: Results of the Korean National Cancer Screening Survey, 2004-2013
Mina Suh, Kui Son Choi, Boyoung Park, Yoon Young Lee, Jae Kwan Jun, Duk-Hyoung Lee, Yeol Kim
Cancer Research and Treatment.2016; 48(1): 1. CrossRef
An Alternative Triage Strategy Based on Preoperative MRI for Avoiding Trimodality Therapy in Stage IB Cervical Cancer
Jung-Yun Lee, Jina Youm, Jae Weon Kim, Kidong Kim, Hak Jae Kim, Jeong Yeon Cho, Min A Kim, Noh Hyun Park, Yong-Sang Song
Cancer Research and Treatment.2016; 48(1): 259. CrossRef
Postoperative biochemical remission of serum calcitonin is the best predictive factor for recurrence‐free survival of medullary thyroid cancer: a large‐scale retrospective analysis over 30 years
Kyong Yeun Jung, Seok‐Mo Kim, Won Sang Yoo, Bup‐Woo Kim, Yong Sang Lee, Kyung Won Kim, Kyu Eun Lee, Jong Ju Jeong, Kee‐Hyun Nam, Se Hoon Lee, Jeong Hun Hah, Woong Youn Chung, Ka Hee Yi, Do Joon Park, Yeo‐Kyu Youn, Myung‐Whun Sung, Bo Youn Cho, Cheong Soo
Clinical Endocrinology.2016; 84(4): 587. CrossRef
Age-Period-Cohort Analysis of Female Breast Cancer Mortality in Korea
Yunhee Choi, Yeonju Kim, Sue K. Park, Hai-Rim Shin, Keun-Young Yoo
Cancer Research and Treatment.2016; 48(1): 11. CrossRef
Some Elements in Thyroid Tissue are Associated with More Advanced Stage of Thyroid Cancer in Korean Women
Hye-Kyung Chung, Ji Sun Nam, Chul Woo Ahn, Yong Sang Lee, Kyung Rae Kim
Biological Trace Element Research.2016; 171(1): 54. CrossRef
Method evaluation of pepsinogen I/II assay based on chemiluminescent immunoassays and comparison with other test methods
Eun-Jung Cho, Hyun-Ki Kim, Tae-Dong Jeong, Dae-Hyun Ko, Suh Eun Bae, Jong-Soo Lee, Woochang Lee, Jae Won Choe, Sail Chun, Hwoon-Yong Jung, Won-Ki Min
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European Journal of Surgical Oncology (EJSO).2016; 42(1): 81. CrossRef
Anti-cancer Effect of Luminacin, a Marine Microbial Extract, in Head and Neck Squamous Cell Carcinoma Progression via Autophagic Cell Death
Yoo Seob Shin, Hyun Young Cha, Bok-Soon Lee, Sung Un Kang, Hye Sook Hwang, Hak Cheol Kwon, Chul-Ho Kim, Eun Chang Choi
Cancer Research and Treatment.2016; 48(2): 738. CrossRef
Population-Based Regional Cancer Incidence in Korea: Comparison between Urban and Rural Areas
Haa-Na Song, Se-Il Go, Won Sup Lee, Yire Kim, Hye Jung Choi, Un Seok Lee, Myoung Hee Kang, Gyeong-Won Lee, Hoon-Gu Kim, Jung Hun Kang, Yune Sik Kang, Jeong-Hee Lee, Jin-Myung Jung, Soon Chan Hong
Cancer Research and Treatment.2016; 48(2): 789. CrossRef
Is There Any Role of Adjuvant Chemotherapy for T3N0M0 or T1N2M0 Gastric Cancer Patients in Stage II in the 7th TNM but Stage I in the 6th TNM System?
Kyung-Goo Lee, Hyuk-Joon Lee, Seung-Young Oh, Jun-Young Yang, Hye-Seong Ahn, Yun-Suhk Suh, Seong-Ho Kong, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Kuhn Uk Lee, Woo Ho Kim, Yung-Jue Bang, Han-Kwang Yang
Annals of Surgical Oncology.2016; 23(4): 1234. CrossRef
Diagnostic group classifications of gastric neoplasms by endoscopic resection criteria before and after treatment: real-world experience
Jun Hee Lee, Yang Won Min, Jun Haeng Lee, Eun Ran Kim, Hyuk Lee, Byung-Hoon Min, Jae J. Kim, Kee-Taek Jang, Kyoung-Mee Kim, Cheol Keun Park
Surgical Endoscopy.2016; 30(9): 3987. CrossRef
Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer
Feng-qi Nie, Shijie Ma, Min Xie, Yan-wen Liu, Wei De, Xiang-hua Liu
Tumor Biology.2016; 37(6): 7693. CrossRef
The caspase 3-dependent apoptotic effect of pycnogenol in human oral squamous cell carcinoma HSC-3 cells
In-Hyoung Yang, Ji-Ae Shin, Lee-Han Kim, Ki Han Kwon, Sung-Dae Cho
Journal of Clinical Biochemistry and Nutrition.2016; 58(1): 40. CrossRef
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
The Korean Journal of Internal Medicine.2016; 31(2): 313. CrossRef
CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Rock Bum Kim, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Cancer Research and Treatment.2016; 48(1): 142. CrossRef
Prevalence rate and clinical characteristics of esophageal ectopic sebaceous glands in asymptomatic health screen examinees
Areum Park, Jung-Hyun Lee, Ayoung Park, Young-Hwan Jung, Hyung-Jun Chu, Sang-Su Bae, Jeong-Kwon Kim, Won-Yong Kim, Byung-Kook Kim
Diseases of the Esophagus.2016; : n/a. CrossRef
Leptomeningeal metastasis: Clinical experience of 519 cases
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European Journal of Cancer.2016; 56: 107. CrossRef
Distinctive Patterns of Initially Presenting Metastases and Clinical Outcomes According to the Histological Subtypes in Stage IV Non-Small Cell Lung Cancer
Dong Soo Lee, Yeon S. Kim, Chul S. Kay, Sung H. Kim, Chang D. Yeo, Jin W. Kim, Seung Joon Kim, Young K. Kim, Yoon H. Ko, Jin H. Kang, Kyo Y. Lee
Medicine.2016; 95(6): e2795. CrossRef
Survival Benefit of Early Cancer Detection Through Regular Endoscopic Screening for De Novo Gastric and Colorectal Cancers in Korean Liver Transplant Recipients
D.H. Jung, S. Hwang, G.W. Song, C.S. Ahn, D.B. Moon, T.Y. Ha, K.H. Kim, G.C. Park, B.S. Kim, I.J. Park, S.B. Lim, J.C. Kim, M.W. Yoo, J.S. Byeon, H.Y. Jung, G.H. Lee, S.J. Myung, J. Choe, J.Y. Choi, H.W. Park, S.G. Lee
Transplantation Proceedings.2016; 48(1): 145. CrossRef
Incidence and Survival of Childhood Cancer in Korea
Hyeon Jin Park, Eun-Kyeong Moon, Ju Young Yoon, Chang-Mo Oh, Kyu-Won Jung, Byung Kiu Park, Hee Young Shin, Young-Joo Won
Cancer Research and Treatment.2016; 48(3): 869. CrossRef
Mammographic Breast Density Evaluation in Korean Women Using Fully Automated Volumetric Assessment
Inyoung Youn, SeonHyeong Choi, Shin Ho Kook, Yoon Jung Choi
Journal of Korean Medical Science.2016; 31(3): 457. CrossRef
The potential of deferasirox as a novel therapeutic modality in gastric cancer
Jung Hye Choi, Jung Soon Kim, Young Woong Won, Jieun Uhm, Byeong Bae Park, Young Yiul Lee
World Journal of Surgical Oncology.2016;[Epub] CrossRef
A nationwide epidemiological study of newly diagnosed spine metastasis in the adult Korean population
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
The Spine Journal.2016; 16(8): 937. CrossRef
Outcomes of fertility-sparing surgery among young women with FIGO stage I clear cell carcinoma of the ovary
Jeong-Yeol Park, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
International Journal of Gynecology & Obstetrics.2016; 134(1): 49. CrossRef
Improvement of clinical outcomes in the patients with gallbladder cancer: lessons from periodic comparison in a tertiary referral center
Jihoon Chang, Jin‐Young Jang, Kyoung Bun Lee, Mee Joo Kang, Woohyun Jung, Yong Chan Shin, Sun‐Whe Kim
Journal of Hepato-Biliary-Pancreatic Sciences.2016; 23(4): 234. CrossRef
Management of long-term colorectal cancer survivors in Korea
Hee-Taik Kang, Hyun Jung Bahk, Jae-Yong Shim, Nam Kyu Kim
Journal of the Korean Medical Association.2016; 59(4): 276. CrossRef
Significance of the Complete Surgical Staging of Stage I Malignant Ovarian Germ Cell Tumors
Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Annals of Surgical Oncology.2016; 23(9): 2982. CrossRef
Lung Cancer in Homeless People: Clinical Outcomes and Cost Analysis in a Single Institute
Koung Jin Suh, Ki Hwan Kim, Jin Lim, Jin Hyun Park, Jin-Soo Kim, In Sil Choi
Canadian Respiratory Journal.2016; 2016: 1. CrossRef
One-Year Experience Managing a Cancer Survivorship Clinic Using a Shared-Care Model for Gastric Cancer Survivors in Korea
Ji Eun Lee, Dong Wook Shin, Hyejin Lee, Ki Young Son, Warrick Junsuk Kim, Yun-Suhk Suh, Seong-Ho Kong, Hyuk Joon Lee, Belong Cho, Han-Kwang Yang
Journal of Korean Medical Science.2016; 31(6): 859. CrossRef
Prognostic significance of CEA expression by RT-PCR in peritoneal wash from patients with gastric cancer: result of a 5-year follow-up after curative resection
Hyun-Dong Chae, In-Hwan Kim
Scandinavian Journal of Gastroenterology.2016; 51(8): 956. CrossRef
Vorinostat in combination with capecitabine plus cisplatin as a first-line chemotherapy for patients with metastatic or unresectable gastric cancer: phase II study and biomarker analysis
Changhoon Yoo, Min-Hee Ryu, Young-Soon Na, Baek-Yeol Ryoo, Chae-Won Lee, Yoon-Koo Kang
British Journal of Cancer.2016; 114(11): 1185. CrossRef
Association between reduction in copayment and gastric cancer patient concentration to the capital area in South Korea: NHI cohort 2003–2013
Kyu-Tae Han, Jeeyun Kim, Chung Mo Nam, Ki Tae Moon, Sang Gyu Lee, Seung Ju Kim, Yeong Jun Ju, Jeoung A Kwon, Sun Jung Kim, Woorim Kim, Eun-Cheol Park
Health Policy.2016; 120(6): 580. CrossRef
Changes in the types of liver diseases requiring hepatic resection: a single-institution experience of 9016 cases over a 10-year period
Hwui-Dong Cho, Shin Hwang, Young-Joo Lee, Kwang-Min Park, Ki-Hun Kim, Jin Cheon Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Sung-Gyu Lee
Korean Journal of Hepato-Biliary-Pancreatic Surgery.2016; 20(2): 49. CrossRef
NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
Jung Hwan Yoon, Jung Woo Eun, Won Suk Choi, Olga Kim, Suk Woo Nam, Jung Young Lee, Won Sang Park
EBioMedicine.2016; 9: 97. CrossRef
Nuclear Medicine in Pediatric and Adolescent Tumors
Pınar Özgen Kiratli, Murat Tuncel, Zvi Bar-Sever
Seminars in Nuclear Medicine.2016; 46(4): 308. CrossRef
Evaluation of Machine Learning Algorithm Utilization for Lung Cancer Classification Based on Gene Expression Levels
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Asian Pacific Journal of Cancer Prevention.2016; 17(2): 835. CrossRef
Prognostic relevance of genetic variants involved in immune checkpoints in patients with colorectal cancer
Shinkyo Yoon, Byung Woog Kang, Su Yeon Park, Hye Jin Kim, Jun Seok Park, Gyu Seog Choi, Jong Gwang Kim
Journal of Cancer Research and Clinical Oncology.2016; 142(8): 1775. CrossRef
The clinical utilization of radiation therapy in Korea between 2009 and 2013
Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
Radiation Oncology Journal.2016; 34(2): 88. CrossRef
Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data
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BMC Cancer.2016;[Epub] CrossRef
Knowledge of HPV and Surgery among Women Who Underwent Cervical Conization: A Korean Multi-Center Study
So Yeun Jun, Se Ik Kim, Myong Cheol Lim, Jung-Yun Lee, San Hui Lee, Yong Jung Song, Kyoung-Chul Chun, Jae Weon Kim, Sang-Yoon Park
Yonsei Medical Journal.2016; 57(5): 1222. CrossRef
High levels of carcinoembryonic antigen and smoking might be markers of colorectal adenoma in Korean males aged 40-49 years
In Cheol Yoon, Jeong Hyeon Cho, Heejin Choi, Young Hoon Choi, Kyu Min Lim, Sung Hwa Choi, Jae Ho Han, Hyeon Ju Jeong, Hong Sub Lee
Yeungnam University Journal of Medicine.2016; 33(1): 13. CrossRef
Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
Cancer Research and Treatment.2016; 48(3): 899. CrossRef
Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX
Mi-Jung Kim, Sae-Won Han, Dae-Won Lee, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Se Hyung Kim, Seock-Ah Im, Yung-Jue Bang, Tae-You Kim
Cancer Research and Treatment.2016; 48(3): 990. CrossRef
Risk factors for lymph node metastasis in papillary thyroid microcarcinoma: Older patients with fewer lymph node metastases
L. Zhang, J. Yang, Q. Sun, Y. Liu, F. Liang, Z. Liu, G. Chen, S. Chen, Z. Shang, Y. Li, X. Li
European Journal of Surgical Oncology (EJSO).2016; 42(10): 1478. CrossRef
Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin
Yoo Seob Shin, Sung Un Kang, Ju Kyeong Park, Yang Eun Kim, Yeon Soo Kim, Seung Joon Baek, Seong-Ho Lee, Chul-Ho Kim
Phytomedicine.2016; 23(12): 1344. CrossRef
Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses
Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park, Dong-Young Noh
BMC Cancer.2016;[Epub] CrossRef
High-risk clinicopathological features and their predictive significance in Korean patients with stage II colon cancer
Ji Soo Park, Hong Jae Chon, Hei-Cheul Jeung, Sang Joon Shin, Sun Young Rha, Joong Bae Ahn, Kang Young Lee, Nam Kyu Kim, Hyun Cheol Chung
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Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data
Gyeong Mi Heo, Mi Hee Kim, Jin Hwan Kim, Young Soo Rho, Woon Geon Shin
The Korean Journal of Gastroenterology.2016; 68(1): 23. CrossRef
Risk of Cardiovascular Disease Using Framingham Risk Score in Korean Cancer Survivors
Ji-Hyun So, Jung-Kwon Lee, Jin-Young Shin, Wan Park
Korean Journal of Family Medicine.2016; 37(4): 235. CrossRef
Factors Associated with Depression Assessed by the Patient Health Questionnaire-2 in Long-Term Cancer Survivors
Ae-Jin Goo, Yun-Mi Song, Jinyoung Shin, Hyeonyoung Ko
Korean Journal of Family Medicine.2016; 37(4): 228. CrossRef
How to Improve the Quality of Screening Endoscopy in Korea: National Endoscopy Quality Improvement Program
Yu Kyung Cho
Clinical Endoscopy.2016; 49(4): 312. CrossRef
Gastric cancer from operating theatre to bench in Korea
H-K Yang
British Journal of Surgery.2016; 103(10): 1251. CrossRef
Current Perspectives on Gastric Cancer
Juan M. Marqués-Lespier, María González-Pons, Marcia Cruz-Correa
Gastroenterology Clinics of North America.2016; 45(3): 413. CrossRef
Chronic Myeloid Leukemia Following Radioactive Iodine Treatment for Thyroid Cancer: Two Case Reports and a Literature Review
Hae Yeul Park, Sung-eun Choi, Young Hoon Ryu, Hang Seok Change, Cheong Soo Park, Kyoung Hwa Lee, Yu Ri Kim
The Korean Journal of Medicine.2016; 91(1): 70. CrossRef
Comparisons of clinicopathologic factors and survival rates between laparoscopic and open gastrectomy in gastric cancer
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International Journal of Surgery.2016; 34: 161. CrossRef
Solitary bone and brain metastasis in a patient with papillary thyroid carcinoma mimicking cavernous angioma
Eugene Han, Ye Yeon Lee, El Kim, Sun Young Kwon, Sang Pyo Kim, Hye Soon Kim, Mi Kyung Kim
The Korean Journal of Internal Medicine.2016; 31(5): 991. CrossRef
Cervical Cancer Screening after Perimenopause: How Is Human Papillomavirus Test Performed?
Soo-Ho Chung
Journal of Menopausal Medicine.2016; 22(2): 65. CrossRef
SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma
Hye Seung Lee, Wonkyung Jung, Eunjung Lee, Hyeyoon Chang, Jin Hyuk Choi, Han Gyeom Kim, Aeree Kim, Baek-hui Kim
Journal of Pathology and Translational Medicine.2016; 50(5): 337. CrossRef
Association between Socioeconomic Status and Cancer Screening in Koreans over 40 Years in Age Based on the 2010–2012 Korean National Health and Nutrition Examination Survey
Jin-Young Kim, Hee-Taik Kang
Korean Journal of Family Medicine.2016; 37(5): 287. CrossRef
Polycyclic aromatic hydrocarbon emissions of non-road diesel engine treated with non-thermal plasma technology
Jianbing Gao, Chaochen Ma, Shikai Xing, Liwei Sun, Jiangquan Liu
Korean Journal of Chemical Engineering.2016; 33(12): 3425. CrossRef
Return-to-Work Experiences among Nurses after Receiving Cancer Treatment
Mi-Hye Kim, Jeong-Seon Kim, Han-Na Kim
Journal of the Korea Academia-Industrial cooperation Society.2016; 17(6): 215. CrossRef
Systematic Review of Trends in the Incidence Rates of Thyroid Cancer
Joseph J. Wiltshire, Thomas M. Drake, Lesley Uttley, Sabapathy P. Balasubramanian
Thyroid.2016; 26(11): 1541. CrossRef
Comparison of survival of surgical resection and conservative treatment in patients with gastric cancer aged 80 years or older: a single-center experience
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Annals of Surgical Treatment and Research.2016; 91(5): 219. CrossRef
Development of a FFQ for breast cancer survivors in Korea
Woo-kyoung Shin, Sihan Song, Eunkyung Hwang, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
British Journal of Nutrition.2016; 116(10): 1781. CrossRef
Adjuvant radiotherapy for the treatment of stage IV rectal cancer after curative resection
Min Jung Kim, Sang Jin Kim, Sung-Chan Park, Dae Yong Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Heung Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Jung Nam Joo, Jae Hwan Oh
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Jieun Kim, Su Mi Kim, Man Ho Ha, Jeong Eun Seo, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Sin-Ho Jung, Jae Moon Bae
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Prevalence of Insomnia among Patients with the Ten Most Common Cancers in South Korea: Health Insurance Review and Assessment Service-National Patient Sample
Boram Park, Soyoung Youn, Chi-Won Christine Hann, Kikyung Yi, Suyeon Lee, Jung-Sun Lee, Seockhoon Chung
Sleep Medicine Research.2016; 7(2): 48. CrossRef
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Hye rim Ha, Do-Youn Oh, Tae-Yong Kim, KyoungBun Lee, Kyubo Kim, Kyung-Hun Lee, Sae-Won Han, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Yung-Jue Bang, John Souglakos
PLOS ONE.2016; 11(3): e0151406. CrossRef
Converged Study on the Nurses' Knowledge and Performance of Cancer Pain Management in one city
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Journal of the Korea Convergence Society.2016; 7(6): 115. CrossRef
Metastatic prostate cancer initially presenting as chylothorax: A case report
YU-JIN YANG, MINJUNG SEO, HEE-JEONG JEON, JIN-HEE NOH, SEOL HOON PARK, YUNSUK CHOI, JAE-CHEOL JO, JIN HO BAEK, SU-JIN KOH, HAWK KIM, YOUNG JOO MIN
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Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer
HYE YOUN SUNG, JIHYE HAN, WOONG JU, JUNG-HYUCK AHN
Oncology Reports.2016; 36(1): 535. CrossRef
Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells
MIN-HO HAN, WON SUP LEE, ARULKUMAR NAGAPPAN, HYE JUNG KIM, CHEOL PARK, GI-YOUNG KIM, SANG HOON HONG, NAM DEUK KIM, GONSUP KIM, CHUNG HO RYU, SUNG CHUL SHIN, YUNG HYUN CHOI
Oncology Reports.2016; 36(1): 99. CrossRef
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Sang Hyuk Lee, Kyu-Hyoung Lim, Seo-Young Song, Hui-Young Lee, Sung Chul Park, Chang Don Kang, Sung Joon Lee, Dong Wook Choi, Sung Bae Park, Young-Joon Ryu
World Journal of Gastroenterology.2016; 22(16): 4270. CrossRef
Synchronous and Metachronous Colon Cancers in Patients with Gastric Cancer: Report of 2 Cases
Byoung Jo Suh
Case Reports in Oncology.2016; 9(3): 752. CrossRef
Impact of Perceived Cancer Risk on the Cancer Screening Rate in the General Korean Population: Results from the Korean Health Panel Survey Data
Jae-Hyun Kim, Eun-Cheol Park, Ki-Bong Yoo
Asian Pacific Journal of Cancer Prevention.2015; 15(23): 10525. CrossRef
Transenteral Bowel Preparation for Colonoscopy Is More Comfortable than the Traditional Method with No Inferiority in Efficacy
Sung-Won Jung, Da Hye Jung, Young Chul Shin, In Ho Moh, Hana Yoo, Sung Il Jang, Su Rin Shin, Jin Bae Kim, Sang Hoon Park, Myung Seok Lee
Digestive Diseases and Sciences.2015; 60(1): 54. CrossRef
Cytochrome P450 1 family and cancers
Ryeo-Eun Go, Kyung-A Hwang, Kyung-Chul Choi
The Journal of Steroid Biochemistry and Molecular Biology.2015; 147: 24. CrossRef
Pharmacokinetic Properties of Two Erlotinib 150 mg Formulations with a Genetic Effect Evaluation in Healthy Korean Subjects
Hyun-Gyu Choi, Ji-Young Jeon, Yong-Jin Im, Yunjeong Kim, Eun-Kee Song, Young-Hwan Seo, Seok-Je Cho, Min-Gul Kim
Clinical Drug Investigation.2015; 35(1): 31. CrossRef
Effect of endoscopy screening on stage at gastric cancer diagnosis: results of the National Cancer Screening Programme in Korea
K S Choi, J K Jun, M Suh, B Park, D K Noh, S H Song, K W Jung, H-Y Lee, I J Choi, E-C Park
British Journal of Cancer.2015; 112(3): 608. CrossRef
Incidence of cancer in children aged 0–14 years in Taiwan, 1996–2010
Yen-Lin Liu, Wei-Cheng Lo, Chun-Ju Chiang, Ya-Wen Yang, Meng-Yao Lu, Wen-Ming Hsu, Wan-Ling Ho, Meng-Ju Li, James S. Miser, Dong-Tsamn Lin, Mei-Shu Lai
Cancer Epidemiology.2015; 39(1): 21. CrossRef
RPM peptide conjugated bioreducible polyethylenimine targeting invasive colon cancer
Yeong Mi Lee, Duhwan Lee, Jihoon Kim, Hansoo Park, Won Jong Kim
Journal of Controlled Release.2015; 205: 172. CrossRef
Intraoperatively Assessed Macroscopic Serosal Changes in Patients with Curatively Resected Advanced Gastric Cancer: Clinical Implications for Prognosis and Peritoneal Recurrence
Changhoon Yoo, Min-Hee Ryu, Young Soo Park, Moon-Won Yoo, Sook Ryun Park, Baek-Yeol Ryoo, Se Jin Jang, Jeong Hwan Yook, Byung Sik Kim, Yoon-Koo Kang
Annals of Surgical Oncology.2015; 22(9): 2940. CrossRef
Multicenter phase II study of trastuzumab in combination with capecitabine and oxaliplatin for advanced gastric cancer
Min-Hee Ryu, Changhoon Yoo, Jong Gwang Kim, Baek-Yeol Ryoo, Young Soo Park, Sook Ryun Park, Hye-Suk Han, Ik Joo Chung, Eun-Kee Song, Kyung Hee Lee, Seok Yun Kang, Yoon-Koo Kang
European Journal of Cancer.2015; 51(4): 482. CrossRef
Renal cryoablation of small renal masses: A Korea University experience
Hyung Keun Kim, Jong Hyun Pyun, Jae Yoon Kim, Seung Bin Kim, Seok Cho, Sung Gu Kang, Jeong Gu Lee, Je Jong Kim, Jun Cheon, Seok Ho Kang
Korean Journal of Urology.2015; 56(2): 117. CrossRef
Effects of oriental medicine music therapy in an ovarian cancer patient with So-Eum-type constitution: a case report
Seung-Hyun Lee, Eunhye Song, Seul-Ki Kim
Integrative Medicine Research.2015; 4(1): 48. CrossRef
Survival outcome in endometrial cancer patients according to hereditary predisposition
Heon Jong Yoo, Myong Cheol Lim, Yedong Son, Sang-Soo Seo, Sokbom Kang, Sun Ho Kim, Chong Woo Yoo, Sang-Yoon Park
Taiwanese Journal of Obstetrics and Gynecology.2015; 54(1): 24. CrossRef
Ultimate eradication rate of Helicobacter pylori after first, second, or third‐line therapy in Korea
Kichul Yoon, Nayoung Kim, Ryoung H Nam, Ji H Suh, Seonmin Lee, Jung M Kim, Ju Y Lee, Yong H Kwon, Yoon J Choi, Hyuk Yoon, Cheol M Shin, Young S Park, Dong H Lee
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Gastric Cancer Screening Uptake Trends in Korea
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Medicine.2015; 94(8): e533. CrossRef
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Cancer Letters.2015; 361(2): 197. CrossRef
Imaging Surveillance of Patients with Breast Cancer after Primary Treatment: Current Recommendations
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Korean Journal of Radiology.2015; 16(2): 219. CrossRef
Prevalence and Characteristics of Chemotherapy-related Cognitive Impairment in Patients with Breast Cancer
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Journal of Korean Academy of Nursing.2015; 45(1): 118. CrossRef
Factors Affecting the Locoregional Recurrence of Conventional Papillary Thyroid Carcinoma After Surgery: A Retrospective Analysis of 3381 Patients
Yong Joon Suh, Hyungju Kwon, Su-jin Kim, June Young Choi, Kyu Eun Lee, Young Joo Park, Do Joon Park, Yeo-Kyu Youn
Annals of Surgical Oncology.2015; 22(11): 3543. CrossRef
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Asian Journal of Endoscopic Surgery.2015; 8(2): 130. CrossRef
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Journal of the Korean Medical Association.2015; 58(3): 209. CrossRef
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Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Pancreatic Lesions
Hae Woon Baek, Min Jee Park, Ye-Young Rhee, Kyoung Bun Lee, Min A Kim, In Ae Park
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Feasibility of terahertz reflectometry for discrimination of human early gastric cancers
Young Bin Ji, Chan Hyuk Park, Hyunki Kim, Sang-Hoon Kim, Gyu Min Lee, Sam Kyu Noh, Tae-In Jeon, Joo-Hiuk Son, Yong-Min Huh, Seungjoo Haam, Seung Jae Oh, Sang Kil Lee, Jin-Suck Suh
Biomedical Optics Express.2015; 6(4): 1398. CrossRef
Proportion and Clinical Outcomes of Postoperative Radiotherapy Omission after Breast-Conserving Surgery in Women with Breast Cancer
Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Won Park, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Won Ho Kil, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park
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Korean Journal of Pancreas and Biliary Tract.2015; 20(1): 22. CrossRef
A Comparison of Outcomes of Three Reconstruction Methods after Laparoscopic Distal Gastrectomy
Chang Hyun Kim, Kyo Young Song, Cho Hyun Park, Young Joo Seo, Seung-Man Park, Jin-Jo Kim
Journal of Gastric Cancer.2015; 15(1): 46. CrossRef
A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer
Eun Na Cho, Hye Sung Park, Tae Hoon Kim, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang
Tuberculosis and Respiratory Diseases.2015; 78(2): 112. CrossRef
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Yong-Hyub Kim, Sang-Yun Song, Hyun-Jeong Shim, Woong-Ki Chung, Sung-Ja Ahn, Mee Sun Yoon, Jae-Uk Jeong, Ju-Young Song, Taek-Keun Nam
Radiation Oncology Journal.2015; 33(1): 12. CrossRef
Sex Differences Associated With Hepatitis B Virus Surface Antigen Seropositivity Unwareness in Hepatitis B Virus Surface Antigen-positive Adults: 2007‐2012 Korea National Health and Nutrition Examination Survey
Suk-Yong Jang, Sung-In Jang, Hong-Chul Bae, Jaeyong Shin, Eun-Cheol Park
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A phase I/II trial of second-line chemotherapy with paclitaxel and irinotecan in fluoropyrimidine- and platinum-pretreated patients with advanced gastric cancer
Jin Won Kim, In Sil Choi, Yu Jung Kim, Kyung-Hun Lee, Keun-Wook Lee, Tae-Yong Kim, Sae-Won Han, Jee Hyun Kim, Tae-You Kim, Jong Seok Lee, Yung-Jue Bang, Seock-Ah Im, Do-Youn Oh
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The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells
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Saudi Journal of Biological Sciences.2015; 22(6): 752. CrossRef
Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors
Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Gynecologic Oncology.2015; 137(3): 418. CrossRef
Overdiagnosis: epidemiologic concepts and estimation
Jong-Myon Bae
Epidemiology and Health.2015; 37: e2015004. CrossRef
Association of Depression and Survival in Patients with Cancer over 10 Years
Joohyung Kim, Suk Jeong Lee, Jae-Kyung Roh, Sang Jun Shin
Asian Oncology Nursing.2015; 15(1): 37. CrossRef
The Influence of Stress, Spousal Support, and Resilience on the Ways of Coping among Women with Breast Cancer
Jiyoung Kang, Eunyoung E. Suh
Asian Oncology Nursing.2015; 15(1): 1. CrossRef
Epidemiological evidences on overdiagnosis of prostate and kidney cancers in Korean
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Epidemiology and Health.2015; 37: e2015015. CrossRef
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Research and Treatment.2015; 47(2): 127. CrossRef
Prediction of Cancer Incidence and Mortality in Korea, 2015
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Research and Treatment.2015; 47(2): 142. CrossRef
The Korean guideline for thyroid cancer screening
Ka Hee Yi, Soo Young Kim, Do Hoon Kim, Sun Wook Kim, Dong Gyu Na, You Jin Lee, Ki Wook Chung, Kui Son Choi, Yoon Woo Koh, Won Bae Kim, Kee-Hyun Nam, Seung-Kuk Baek, Jung Hwan Baek, Soon Young Lee, Yuh Seok Jung, Jung Jin Cho, Young-Su Ju, Ji Yeon Dang, Ye
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Flavonoids from Orostachys Japonicus A. Berger Induces Caspase-dependent Apoptosis at Least Partly through Activation of p38 MAPK Pathway in U937 Human Leukemic Cells
Won Sup Lee, Jeong Won Yun, Arulkumar Nagappan, Ji Hyun Jung, Sang Mi Yi, Dong Hoon Kim, Hye Jung Kim, GonSup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jung
Asian Pacific Journal of Cancer Prevention.2015; 16(2): 465. CrossRef
The impact of job status on quality of life: general population versus long-term cancer survivors
Seo Yoon Lee, Sun Jung Kim, Jaeyong Shin, Kyu-Tae Han, Eun-Cheol Park
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Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009–2012
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na-Rye Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
Neuro-Oncology Practice.2015; 2(2): 93. CrossRef
Distribution of the Colonoscopic Adenoma Detection Rate According to Age: Is Recommending Colonoscopy Screening for Koreans Over the Age of 50 Safe?
Taeseok Bae, Yunhyung Ha, Changkyun Kim, Jihyun Lee, Kwangil Ha, Sanghyun Shin, Youngcheol Lee, Yoonsik Kang
Annals of Coloproctology.2015; 31(2): 46. CrossRef
Laughter and Stress Relief in Cancer Patients: A Pilot Study
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Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef
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Epidemiology and Health.2015; 37: e2015018. CrossRef
The Association between the Adherence to Dietary Guidelines for Breast Cancer Survivors and Health-related Quality of Life among Korean Breast Cancer Survivors
Sihan Song, Jiyoung Youn, Myungsook Park, Eunkyung Hwang, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
Korean Journal of Community Nutrition.2015; 20(2): 129. CrossRef
Multivalent Aptamer/Gold Nanoparticle–Modified Graphene Oxide for Mass Spectrometry–Based Tumor Tissue Imaging
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Hyun Ah Park, Su Youn Nam, Sang Kil Lee, Sang Gyun Kim, Ki-Nam Shim, Sang Min Park, Sun-Young Lee, Hye Seung Han, Yong Moon Shin, Kyoung-Mee Kim, Kyung-Jae Lee, Tae-Yong Lee, Il Ju Choi, Seong Sook Hong, Jae Woo Kim, Yoon Jae Lee, Soo Young Kim, Yeol Kim,
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Awareness of cervical cancer prevention among mothers of adolescent daughters in Korea: qualitative research
Hae Won Kim, Duck Hee Kim
BMJ Open.2015; 5(5): e006915. CrossRef
Incidence of kidney, bladder, and prostate cancers in Korea: An update
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Korean Journal of Urology.2015; 56(6): 422. CrossRef
Trends of liver cancer and its major risk factors in Korea
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The Effect of Gamisoyo-san Intravenous Pharmacopuncture on Restoration of Liver Function after Partial Hepatectomy in SD Rat
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Journal of Korean Medicine.2015; 36(1): 22. CrossRef
Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2008~2013
Sun Jin Park, Kil Yeon Lee, Suk-Hwan Lee
The Journal of Minimally Invasive Surgery.2015; 18(2): 39. CrossRef
The Basic Facts of Korean Breast Cancer in 2012: Results from a Nationwide Survey and Breast Cancer Registry Database
Zisun Kim, Sun Young Min, Chan Seok Yoon, Kyu-Won Jung, Beom Seok Ko, Eunyoung Kang, Seok Jin Nam, Seokwon Lee, Min Hee Hur
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Development of Job Standards of Clinical Dietitian for the Clinical Nutrition Therapy to Cancer Patients in Hospitals
Soo-Kyong Choi, Gyung-Ah Wie, Song-Mi Lee, Eun Mi Kim, Mi-Sun Park, Cheongmin Sohn, Mi-Hye Woo, Dal Lae Ju, Jin-A Cha, Jung-Sook Seo
Journal of the Korean Dietetic Association.2015; 21(2): 91. CrossRef
Factors Influencing Quality of Life in Patients with Hepatocellular Carcinoma Receiving Transarterial Chemoembolization
Hyoung-Sook Park, Hyun-Ju Lee, Jae-Hyun Ha
Journal of Korean Academy of Fundamentals of Nursing.2015; 22(1): 69. CrossRef
Alcohol Drinking, Cigarette Smoking and Risk of Colorectal Cancer in the Korean Multi-center Cancer Cohort
Sooyoung Cho, Aesun Shin, Sue K. Park, Hai-Rim Shin, Soung-Hoon Chang, Keun-Young Yoo
Journal of Cancer Prevention.2015; 20(2): 147. CrossRef
Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members
Jin-Woo Jeong, Won Sup Lee, Se-il Go, Arulkumar Nagappan, Jun Young Baek, Jae-Dong Lee, Su-Jae Lee, Cheol Park, Gi Young Kim, Hye Jung Kim, Gon-Sup Kim, Taeg Kyu Kwon, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi
Phytotherapy Research.2015; 29(10): 1516. CrossRef
Tumour volume changes assessed with high-quality KVCT in lung cancer patients undergoing concurrent chemoradiotherapy
Y H Lee, Y S Kim, H C Lee, S W Lee, Y N Kang, J H Kang, S H Hong, Y K Kim, S J Kim, M I Ahn, D H Han, I R Yoo, J G Park, S W Sung, K Y Lee
The British Journal of Radiology.2015; 88(1052): 20150156. CrossRef
Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates
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Jun Hyeok Kang, Se Hyun Nam, Taejong Song, Woo Young Kim, Kyo Won Lee, Kye Hyun Kim
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The Economic Burden of Cancers Attributable to Metabolic Syndrome in Korea
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The Prognostic Importance of the Number of Metastatic Lymph Nodes for Patients Undergoing Curative Resection Followed by Adjuvant Chemoradiotherapy for Extrahepatic Bile Duct Cancer
Byoung Hyuck Kim, Kyubo Kim, Eui Kyu Chie, Jeanny Kwon, Jin-Young Jang, Sun Whe Kim, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang, Sung W. Ha
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Race and ethnicity considerations in GI endoscopy
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Seung-Hyun Ma, Woohyun Jung, Elisabete Weiderpass, Jieun Jang, Yunji Hwang, Chunghyun Ahn, Kwang-Pil Ko, Soung-Hoon Chang, Hai-Rim Shin, Keun-Young Yoo, Sue K Park
British Journal of Cancer.2015; 113(9): 1381. CrossRef
Variable Endoscopic Findings and Clinicopathological Characteristics of Borrmann Type 4 Advanced Gastric Cancer
Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, A Reum Choe, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2015; 15(3): 166. CrossRef
Qualitative study on experience of health behavior among Korean low-income breast cancer survivors
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Journal of the Korea Academia-Industrial cooperation Society.2015; 16(5): 3188. CrossRef
A Case of Sparganosis that Mimicked Recurrence of Contralateral Breast Cancer
Seo Ae Han, Byung Woog Kang, Yee Soo Chae, Jun Seok Yoon, Sang Kyung Seo, Ho Young Park, Ji Yeong Park
The Korean Journal of Medicine.2015; 89(4): 470. CrossRef
Prevalence of Sarcopenia and Its Association with Metabolic Syndrome in Korean Cancer Survivors
Ji Hyun Moon, Mi Hee Kong, Hyeon Ju Kim
The Korean Journal of Obesity.2015; 24(3): 140. CrossRef
Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients
Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park, Tae-You Kim
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Anti-oxidative and Anti-cancer Activities of Treculia africana Extract in Human Colon Adenocarcinoma HT29 Cells
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The performance of a novel amino acid multivariate index for detecting lung cancer: A case control study in Korea
Hee Joung Kim, Seung Hun Jang, Jeong-Seon Ryu, Jeong Eun Lee, Young Chul Kim, Min Ki Lee, Tae Won Jang, Shin-Yup Lee, Hidehiro Nakamura, Natsumi Nishikata, Maiko Mori, Yasushi Noguchi, Hiroshi Miyano, Kye Young Lee
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A qualitative study of women’s views on overdiagnosis and screening for thyroid cancer in Korea
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Assessing Activity Limitation Among Cancer Survivors in Korea Using Data from a Nationwide Survey
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Cost-effectiveness Analysis of Cervical Cancer Screening Strategies Based on the Papanicolaou Smear Test in Korea
Min Jung Ko, Jimin Kim, Younhee Kim, Yoon Jae Lee, Sung Ran Hong, Jae Kwan Lee
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Safety Management Status among Nurses Handling Anticancer Drugs: Nurse Awareness and Performance Following Safety Regulations
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Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012
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Lung cancer risk in professional drivers in Korea: A population‐based proportionate cancer incidence ratio study
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Factors Affecting Prostate Cancer Screening Behavior
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Asian Oncology Nursing.2015; 15(4): 256. CrossRef
MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells
PYOUNG RAK CHOI, YONG JUNG KANG, BOKYUNG SUNG, JAE HYUN KIM, HYUNG RYONG MOON, HAE YOUNG CHUNG, SUNG EUN KIM, MOO IN PARK, SEUN JA PARK, NAM DEUK KIM
International Journal of Oncology.2015; 47(2): 563. CrossRef
The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells
HWANG-BO HYUN, WON SUP LEE, SE-IL GO, ARULKUMAR NAGAPPAN, CHEOL PARK, MIN HO HAN, SU HYUN HONG, GONSUP KIM, GI YOUNG KIM, JAEHUN CHEONG, CHUNG HO RYU, SUNG CHUL SHIN, YUNG HYUN CHOI
International Journal of Oncology.2015; 46(6): 2670. CrossRef
Poncirin Induces Apoptosis in AGS Human Gastric Cancer Cells through Extrinsic Apoptotic Pathway by up-Regulation of Fas Ligand
Venu Saralamma, Arulkumar Nagappan, Gyeong Hong, Ho Lee, Silvia Yumnam, Suchismita Raha, Jeong Heo, Sang Lee, Won Lee, Eun Kim, Gon Kim
International Journal of Molecular Sciences.2015; 16(9): 22676. CrossRef
The Effect of National Cancer Screening on Disparity Reduction in Cancer Stage at Diagnosis by Income Level
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PLOS ONE.2015; 10(8): e0136036. CrossRef
Metachronous Second Primary Malignancies after Head and Neck Cancer in a Korean Cohort (1993-2010)
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Risk of Second Primary Cancer among Prostate Cancer Patients in Korea: A Population-Based Cohort Study
Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Hyunsoon Cho, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won, Shian-Ying Sung
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Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer
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Eunji Choi, Yoon Young Lee, Hyo Joong Yoon, Sangeun Lee, Mina Suh, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi, Ali Montazeri
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Diagnostic Value of Osteopontin in Ovarian Cancer: A Meta-Analysis and Systematic Review
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World Journal of Gastroenterology.2015; 21(43): 12410. CrossRef
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World Journal of Gastroenterology.2015; 21(5): 1457. CrossRef
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World Journal of Gastroenterology.2015; 21(46): 13064. CrossRef
Companion diagnostics for the targeted therapy of gastric cancer
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World Journal of Gastroenterology.2015; 21(39): 10948. CrossRef
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Pediatric Patients With Multifocal Papillary Thyroid Cancer Have Higher Recurrence Rates Than Adult Patients: A Retrospective Analysis of a Large Pediatric Thyroid Cancer Cohort Over 33 Years
Young Ah Lee, Hae Woon Jung, Hwa Young Kim, Hoonsung Choi, Hyun-Young Kim, J. Hun Hah, Do Joon Park, June-Key Chung, Sei Won Yang, Choong Ho Shin, Young Joo Park
The Journal of Clinical Endocrinology & Metabolism.2015; 100(4): 1619. CrossRef
Clinical Application of Genetics in Management of Colorectal Cancer
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Intestinal Research.2014; 12(3): 184. CrossRef
Non-surgical treatment versus radical esophagectomy for clinical T1N0M0 esophageal carcinoma: a single-center experience
Inkeun Park, Yong-Hee Kim, Dok Hyun Yoon, Sook Ryun Park, Hyeong Ryul Kim, Jong Hoon Kim, Hwoon-Yong Jung, Gin Hyug Lee, Kyung-Ja Cho, Sung-Bae Kim
Cancer Chemotherapy and Pharmacology.2014; 74(5): 995. CrossRef
Health promotion and disease prevention in the older adults
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Journal of the Korean Medical Association.2014; 57(9): 756. CrossRef
Methodological issues for determining intervals of subsequent cancer screening
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Epidemiology and Health.2014; 36: e2014010. CrossRef
Comparison of adenocarcinoma and adenosquamous carcinoma in patients with early-stage cervical cancer after radical surgery
Min-Hyun Baek, Jeong-Yeol Park, Daeyeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Gynecologic Oncology.2014; 135(3): 462. CrossRef
Two Hypotheses of Dense Breasts and Viral Infection for explaining incidence rates of breast cancer by age group in Korean women
Jong-Myon Bae
Epidemiology and Health.2014; : e2014020. CrossRef
Serum prostate-specific antigen levels and type of work in tire manufacturing workers
Soo-Hyeon Kim, Keun-Ho Jang, Won-Ju Park, Do-Hyeong Kwon, Won-Yang Kang, Hyeong-Min Lim, Jai-Dong Moon
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Korean Journal of Medicine.2014; 87(5): 521. CrossRef
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The Lancet.2014; 384(9957): 1848. CrossRef
A prospective cohort study on postoperative radiotherapy with TomoDirect using simultaneous integrated boost technique in early breast cancer
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Radiation Oncology.2014;[Epub] CrossRef
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Young Doo Kim, Won Ki Bae, Yun Ho Choi, Yoon Jung Jwa, Sang Kyung Jung, Bu Hyun Lee, Woo Hyun Paik, Jong Wook Kim, Nam-Hoon Kim, Kyung-Ah Kim, June Sung Lee
The Korean Journal of Gastroenterology.2014; 64(5): 278. CrossRef
Prevention Strategies for Gastric Cancer: A Global Perspective
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Clinical Endoscopy.2014; 47(6): 478. CrossRef
Endoscopic Gastric Cancer Screening and Surveillance in High-Risk Groups
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Original Articles

Trends in Cancer Screening Rates among Korean Men and Women: Results from the Korean National Cancer Screening Survey (KNCSS), 2004-2010: Eun-Ha Lee, Hoo-Yeon Lee, Kui Son Choi, Jae Kwan Jun, Eun-Cheol Park, Jin Soo Lee; Cancer Res Treat. 2011;43(3):141-147. Published online September 30, 2011; DOI: https://doi.org/10.4143/crt.2011.43.3.141

Abstract PDF PubReader ePub

PURPOSE
The Korean National Cancer Screening Survey (KNCSS) is a continuous nationwide survey implemented by the National Cancer Center in Korea since 2004. The purpose of the present study was to report trends in cancer screening rates for the five major cancers (stomach, liver, colorectal, breast, and cervix uteri) in Korean men and women.
MATERIALS AND METHODS
The study used KNCSS data collected between 2004 and 2010. The survey was conducted on Korean men aged 40-74 years and Korean women aged 30-74 years with no history of cancer diagnosis. The annual percentage change and corresponding 95% confidence intervals were used to examine changes in annual screening rates.
RESULTS
Screening rates with recommendation increased by 4.4% annually for stomach cancer, 1.5% for liver cancer, 2.8% per year for colorectal cancer, 4.5% for breast cancer, and 1.2% for cervix uteri cancer. The increasing trend in cancer screening rates, with the exception of liver cancer, was significant.
CONCLUSION
Cancer screening rates have increased consistently from 2004 to 2010 among Korean men and women. Stomach and breast cancer screening rates in particular have increased markedly.

Citations

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Breast Cancer Research and Treatment.2019; 173(1): 189. CrossRef
A Theory-Based and Culturally Aligned Training Program on Breast and Cervical Cancer Prevention for South Asian Community Health Workers
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Cancer Nursing.2019; 42(2): E20. CrossRef
Effects of Screening on Gastric Cancer Management: Comparative Analysis of the Results in 2006 and in 2011
Yun Gyoung Kim, Seong-Ho Kong, Seung-Young Oh, Kyung-Goo Lee, Yun-Suhk Suh, Jun-Young Yang, Jeongmin Choi, Sang Gyun Kim, Joo-Sung Kim, Woo Ho Kim, Hyuk-Joon Lee, Han-Kwang Yang
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Mina Yu, Joo Hwan Lee, Hong Seok Jang, Dong Min Jeon, Jae Suk Cheon, Hyo Chun Lee, Jong Hoon Lee
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Clinical Characteristics of Malignant Pericardial Effusion Associated with Recurrence and Survival: Sung-Hwan Kim, Mi Hyang Kwak, Sohee Park, Hak Jin Kim, Hyun-Sung Lee, Moon Soo Kim, Jong Mog Lee, Jae Ill Zo, Jung Sil Ro, Jin Soo Lee; Cancer Res Treat. 2010;42(4):210-216. Published online December 31, 2010; DOI: https://doi.org/10.4143/crt.2010.42.4.210

Abstract PDF PubReader ePub

Purpose

We evaluated clinical outcomes after drainage for malignant pericardial effusion with imminent or overt tamponade.

Materials and Methods

Between August 2001 and June 2007, 100 patients underwent pericardiocentesis for malignant pericardial effusion. Adequate follow-up information on the recurrence of pericardial effusion and survival status was available for 98 patients.

Results

Recurrence of effusion occurred in 30 patients (31%), all of whom were diagnosed with adenocarcinoma. Multivariate analysis indicated that adenocarcinoma of the lung (hazard ratio [HR], 6.6; 95% confidence interval [CI], 1.9 to 22.3; p=0.003) and progressive disease despite chemotherapy (HR, 4.3; 95% CI, 1.6 to 12.0; p=0.005) were independent predictors of recurrence. Survival rates three months after pericardiocentesis differed significantly with the type of primary cancer; the rates were 73%, 18%, 90% and 30% in patients with adenocarcinoma of the lung, squamous cell carcinoma of the lung, breast cancer and other cancers, respectively.

Conclusion

Recurrence and survival of patients with malignant pericardial effusion are dependent on the type of primary cancer and response to chemotherapy. Patients with adenocarcinoma of the lung may be good candidates for surgical drainage to avoid repeated pericardiocentesis, but pericardiocentesis is considered effective as palliative management in patients with other cancers.

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Case Report

Plasmablastic Lymphoma in the Anal Canal: Joo Han Lim, Moon Hee Lee, Man Jong Lee, Chul Soo Kim, Jin Soo Lee, Suk Jin Choi, Hyeon Gyu Yi; Cancer Res Treat. 2009;41(3):182-185. Published online September 28, 2009; DOI: https://doi.org/10.4143/crt.2009.41.3.182

Abstract PDF PubReader ePub

Plasmablastic lymphoma (PBL) of the oral cavity is an acquired immunodeficiency syndrome-related lymphoma. The immunophenotype of this disease is associated with poor expression of B-cell markers but a positive reactivity for plasma cell markers. PBL is highly aggressive and responds poorly to treatment. Although originally described in the oral cavity, this disease can occur in other body niches. Here, we describe a very rare case of PBL in the anal canal of a 40-year-old woman with human immunodeficiency virus infection. The malignant cells were positive for Epstein-Barr virus and human herpes virus 8.

Citations

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Anal lymphoma: a tumor with insufficient attention
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Review Article

Passive Smoking and Lung Cancer: Hwangbo Bin, Jin Soo Lee; Cancer Res Treat. 2003;35(2):90-95. Published online April 30, 2003; DOI: https://doi.org/10.4143/crt.2003.35.2.90

Abstract PDF: Passive smoking is an important risk factor for lung cancer and its impact might be more significant than generally appreciated in Korea. We reviewed the literatures that support the biologic plausibility of Environmental Tobacco Smoke (ETS) causing lung cancer and summarized epidemiological evidences. Because ETS exposure is a preventable risk factor, more social efforts should be directed to reduce ETS exposure.

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