Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
1 "Jian-Yong Shao"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients
Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Ming-Yuan Chen, Chong Zhao, Xiang Guo, Chao-Nan Qian, Mu-Sheng Zeng, Jin-Xin Bei, Jing Tan, Shuai Chen, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Hai-Qiang Mai
Cancer Res Treat. 2018;50(1):19-29.   Published online April 5, 2017
DOI: https://doi.org/10.4143/crt.2016.595
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC).
Materials and Methods
A total of 413 consecutive stage II-IVb NPC patients treated with concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared using the log-rank test.
Results
A minimum (mini)–absolute lymphocyte counts (ALC) of < 390 cells/μL or ALC after 3 months of CCRT (post3m-ALC) < 705 cells/μL was significantly associated with worse outcome than mini-ALC ≥ 390 cells/μL (OS, p=0.002; PFS, p=0.005; DMFS, p=0.004) or post3m-ALC ≥ 705 cells/μL (OS, p < 0.001; PFS, p < 0.001; DMFS, p=0.001). Patients with lymphopenia (mini-ALC < 390 cells/μL and post3m-ALC < 705 cells/μL) had a worse prognosis than those without lymphopenia (mini-ALC ≥ 390 cells/μL and post3m-ALC ≥ 705 cells/μL) (OS, p < 0.001; PFS, p < 0.001; DMFS, p < 0.001). Multivariate analysis revealed that post3m-ALC was an independent prognostic factor for OS (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.12 to 2.78; p=0.015), PFS (HR, 1.86; 95% CI, 1.23 to 2.82; p=0.003), and DMFS (HR, 1.87; 95% CI, 1.13 to 3.08; p=0.014). Multivariate analysis also revealed that patients with lymphopenia had a high risk of death (HR, 3.79; 95% CI, 1.75 to 8.19; p=0.001), disease progression (HR, 2.93; 95% CI, 1.59 to 5.41; p=0.001), and distant metastasis (HR, 3.89; 95% CI, 1.67 to 9.10; p=0.002). Multivariate analysis performed with time dependent Cox regression demonstrated ALC was an independent prognostic factor for OS (HR, 0.995; 95% CI, 0.991 to 0.999; p=0.025) and PFS (HR, 0.993; 95% CI, 0.988 to 0.998; p=0.006).
Conclusion
Treatment-related lymphopenia was a poor prognostic factor in NPC patients.

Citations

Citations to this article as recorded by  
  • Nomograms containing body dose parameters for predicting survival in patients with nasopharyngeal carcinoma
    Jianyun Jiang, Ruiping Zhai, Fangfang Kong, Chengrun Du, Hongmei Ying
    European Archives of Oto-Rhino-Laryngology.2024; 281(1): 181.     CrossRef
  • Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study
    Wei-Wei Zhang, Jia-Yi Lin, Gao-Yuan Wang, Cheng-Long Huang, Ling-Long Tang, Yan-Ping Mao, Guan-Qun Zhou, Li-Zhi Liu, Li Tian, Ji-Bin Li, Jun Ma, Rui Guo
    Radiotherapy and Oncology.2024; 194: 110189.     CrossRef
  • Reduced-Volume Irradiation of Uninvolved Neck in Patients With Nasopharyngeal Cancer: Updated Results From an Open-Label, Noninferiority, Multicenter, Randomized Phase III Trial
    Cheng-Long Huang, Ning Zhang, Wei Jiang, Fang-Yun Xie, Xiao-Qing Pei, Shao Hui Huang, Xue-Yan Wang, Yan-Ping Mao, Kun-Peng Li, Qing Liu, Ji-Bin Li, Shao-Qiang Liang, Guan-Jie Qin, Wei-Han Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Lei Chen, Ling-Long Tang
    Journal of Clinical Oncology.2024; 42(17): 2021.     CrossRef
  • Immunological effects of radiopharmaceutical therapy
    Amanda G. Shea, Malick Bio Idrissou, Ana Isabel Torres, Tessa Chen, Reiner Hernandez, Zachary S. Morris, Quaovi H. Sodji
    Frontiers in Nuclear Medicine.2024;[Epub]     CrossRef
  • Current Status and Future Directions of Proton Therapy for Head and Neck Carcinoma
    Sara Lillo, Alfredo Mirandola, Alessandro Vai, Anna Maria Camarda, Sara Ronchi, Maria Bonora, Rossana Ingargiola, Barbara Vischioni, Ester Orlandi
    Cancers.2024; 16(11): 2085.     CrossRef
  • Treatment-Related Lymphopenia is Possibly a Marker of Good Prognosis in Nasopharyngeal Carcinoma: a Propensity-Score Matching Analysis
    Ke-gui Weng, Hai-ke Lei, De-Song Shen, Ying Wang, Xiao-Dong Zhu
    Cancer Management and Research.2024; Volume 16: 603.     CrossRef
  • A prognostic nomogram for patients with III–IV nasopharyngeal carcinoma based on dynamic changes in the inflammatory and nutrition index
    Guangyi Cheng, Shiwang Yuan, Jiang Wang, Sijia Deng, Yang Wu, Yuyan Wang, Yu Shen, Liantao Li
    Clinical and Translational Oncology.2024;[Epub]     CrossRef
  • Impact of Radiation Dose to Circulating Immune Cells on Tumor Control and Survival in Esophageal Cancer
    Shang Cai, Yawen Fan, Qi Guo, Yanze Sun, Peifeng Zhao, Ye Tian, Qiuhong Fan
    Cancer Biotherapy and Radiopharmaceuticals.2023; 38(6): 380.     CrossRef
  • Meta-analysis and Critical Review: Association Between Radio-induced Lymphopenia and Overall Survival in Solid Cancers
    Yasmine El Houat, Christophe Massard, Veronique Quillien, Renaud de Crevoisier, Joël Castelli
    Advances in Radiation Oncology.2023; 8(2): 101038.     CrossRef
  • The prognostic predictive value of systemic immune index and systemic inflammatory response index in nasopharyngeal carcinoma: A systematic review and meta-analysis
    Li Wang, Xianfei Qin, Yu Zhang, Shouyu Xue, Xicheng Song
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Prognostic Significance of the Post-Treatment Neutrophil-to-Lymphocyte Ratio in Pharyngeal Cancers Treated with Concurrent Chemoradiotherapy
    Ji Min Yun, Man Ki Chung, Chung Hwan Baek, Young Ik Son, Myung Ju Ahn, Dongryul Oh, Ki Won Kim, Yoon Kyoung So
    Cancers.2023; 15(4): 1248.     CrossRef
  • Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma
    Zhaodong Fei, Huiling Hong, Ting Xu, Yiying Xu, Jiawei Chen, Xiufang Qiu, Jianming Ding, Ye Feng, Chaoxiong Huang, Li Li, Mengying Li, Chuanben Chen
    BMC Cancer.2023;[Epub]     CrossRef
  • Higher radiation dose on immune cells is associated with radiation-induced lymphopenia and worse prognosis in patients with locally advanced esophageal squamous cell carcinoma
    Jianjian Qiu, Hancui Lin, Dongmei Ke, Yilin Yu, Jiaying Xu, Hejin Qiu, Qunhao Zheng, Hui Li, Hongying Zheng, Lingyun Liu, Zhiping Wang, Qiwei Yao, Jiancheng Li
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
    Rema Shah, Christina Liu, Hemali P. Shah, Benjamin L. Judson
    Laryngoscope Investigative Otolaryngology.2023; 8(4): 870.     CrossRef
  • Dosimetric Effect of Thymus and Thoracic Duct on Radiation-Induced Lymphopenia in Patients With Primary Lung Cancer Who Received Thoracic Radiation
    Jinliang Zhang, Li Yang, Hui Li, Jeff W. Chan, Eric K.W. Lee, Min Liu, Lingyu Ma, Qin Liu, Jian-Yue Jin, Pingfu Fu, Zhiyuan Xu, Feng-Ming (Spring) Kong
    Advances in Radiation Oncology.2023; 8(6): 101260.     CrossRef
  • Lymphopénie radio-induite : les lymphocytes comme nouvel organe à risque
    P.A. Laurent, É. Deutsch
    Cancer/Radiothérapie.2023; 27(6-7): 511.     CrossRef
  • Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
    Yuanyuan Ma, Chang Guo, Xijun Wang, Xundong Wei, Jie Ma
    Journal of Experimental & Clinical Cancer Research.2023;[Epub]     CrossRef
  • CT-based dosiomics and radiomics model predicts radiation-induced lymphopenia in nasopharyngeal carcinoma patients
    Qingfang Huang, Chao Yang, Jinmeng Pang, Biao Zeng, Pei Yang, Rongrong Zhou, Haijun Wu, Liangfang Shen, Rong Zhang, Fan Lou, Yi Jin, Albert Abdilim, Hekun Jin, Zijian Zhang, Xiaoxue Xie
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Developing the POTOMAC Model: A Novel Prediction Model to Study the Impact of Lymphopenia Kinetics on Survival Outcomes in Head and Neck Cancer Via an Ensemble Tree-Based Machine Learning Approach
    Carmen Kut, Doug Midthune, Emerson Lee, Peyton Fair, Tia Cheunkarndee, Todd McNutt, Theodore DeWeese, Carole Fakhry, Victor Kipnis, Harry Quon
    JCO Clinical Cancer Informatics.2023;[Epub]     CrossRef
  • Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer
    Ku‐Hao Fang, Sheng‐Wei Chang, Yi‐Chan Lee, Ethan I. Huang, Chia‐Hsuan Lai, Geng‐He Chang, Ming‐Shao Tsai, Cheng‐Ming Hsu, Yao‐Te Tsai
    Oral Diseases.2022; 28(7): 1816.     CrossRef
  • A comprehensive model based on temporal dynamics of peripheral T cell repertoire for predicting post-treatment distant metastasis of nasopharyngeal carcinoma
    Yajing Zhang, Yujie Zhu, Jiaqi Wang, Yi Xu, Zekun Wang, Yang Liu, Xuebing Di, Lin Feng, Ye Zhang
    Cancer Immunology, Immunotherapy.2022; 71(3): 675.     CrossRef
  • Identifying distinct risks of treatment failure in nasopharyngeal carcinoma: Study based on the dynamic changes in peripheral blood lymphocytes, monocytes, N classification, and plasma Epstein‐Barr virus DNA
    Li‐Ting Liu, Yu‐Jing Liang, Shan‐Shan Guo, Yao Xie, Guo‐Dong Jia, Dong‐Xiang Wen, Lin‐Quan Tang, Qiu‐Yan Chen, Hai‐Qiang Mai
    Head & Neck.2022; 44(1): 34.     CrossRef
  • Taxane/gemcitabine-containing chemotherapy plus locoregional IMRT for patients with de novo metastatic nasopharyngeal carcinoma: the treatment outcomes and prognostic factors analysis
    Chengrun Du, Mengshan Ni, Jianyun Jiang, Fangfang Kong, Ruiping Zhai, Yingchen Lv, Chaosu Hu, Hongmei Ying
    European Archives of Oto-Rhino-Laryngology.2022; 279(8): 3947.     CrossRef
  • The impact of radiation induced lymphopenia in the prognosis of head and neck cancer: A systematic review and meta-analysis
    Dongjun Dai, Qiaoying Tian, Yongjie Shui, Jinfan Li, Qichun Wei
    Radiotherapy and Oncology.2022; 168: 28.     CrossRef
  • Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma
    Weiqun Lin, Di Cao, Annan Dong, Shaobo Liang, Yongyi Zhao, Cuibing Liu, Yinghua Yan, Xiaoliu Luo, Lizhi Liu, Xinchen Zeng, Qiaowen Ou
    Head & Neck.2022; 44(5): 1086.     CrossRef
  • Radiation Induced Lymphopenia Is Associated With the Effective Dose to the Circulating Immune Cells in Breast Cancer
    Fang Chen, Jian-Yue Jin, Timothy S.K. Hui, Haiman Jing, Hong Zhang, Yaqing Nong, Ying Han, Weili Wang, Lingyu Ma, Fan Yi, Qingqing Chen, Yongsheng Zhang, Pingfu Fu, Li Yang, Zhiyuan Xu, Feng-Ming Spring Kong
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study
    Chao Luo, Shuqi Li, Qin Zhao, Qiaowen Ou, Wenjie Huang, Guangying Ruan, Shaobo Liang, Lizhi Liu, Yu Zhang, Haojiang Li
    Journal of Inflammation Research.2022; Volume 15: 4803.     CrossRef
  • Head and neck cancers volume reduction: should we reduce our prophylactic node radiation to spare the antitumor immune response?
    Y. El Houat, L. Bouvier, M. Baty, X. Palard-Novello, Y. Pointreau, R. de Crevoisier, J. Castelli
    Cancer/Radiothérapie.2022; 26(6-7): 916.     CrossRef
  • Establishment of a prognostic nomogram for patients with locoregionally advanced nasopharyngeal carcinoma incorporating clinical characteristics and dynamic changes in hematological and inflammatory markers
    Qin Liu, Lingyu Ma, Huangrong Ma, Li Yang, Zhiyuan Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers
    Ava Saidian, Isabella Dolendo, Andrew Sharabi, Tyler F. Stewart, Brent Rose, Rana R. McKay, Aditya Bagrodia, Amirali Salmasi
    Cancers.2022; 15(1): 127.     CrossRef
  • Hypofractionated concurrent chemoradiotherapy related lymphopenia and its association with survival in locally advanced non-small cell lung cancer patients
    FangJie Liu, YingJia Wu, JianHui Shao, Bo Qiu, SuPing Guo, QiaoTing Luo, JinYu Guo, DaQuan Wang, Chu Chu, Rui Zhou, NaiBin Chen, XinLei Ai, Hui Liu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Combined radiotherapy and immunotherapy in urothelial bladder cancer: harnessing the full potential of the anti-tumor immune response
    Mame Daro-Faye, Wassim Kassouf, Luis Souhami, Gautier Marcq, Fabio Cury, Tamim Niazi, Paul Sargos
    World Journal of Urology.2021; 39(5): 1331.     CrossRef
  • Lymphopenia During Definitive Chemoradiotherapy in Esophageal Squamous Cell Carcinoma: Association with Dosimetric Parameters and Patient Outcomes
    Hui Xu, Maosheng Lin, Yingying Hu, Li Zhang, Qiaoqiao Li, Jinhan Zhu, Shi Wang, Mian Xi
    The Oncologist.2021; 26(3): e425.     CrossRef
  • Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy
    Michael I. Koukourakis, Alexandra Giatromanolaki
    Critical Reviews in Oncology/Hematology.2021; 159: 103226.     CrossRef
  • Hematological toxicity in patients with solid malignant tumors treated with radiation – Temporal analysis, dose response and impact on survival
    Cynthia Terrones-Campos, Bruno Ledergerber, Ivan Richter Vogelius, Marie Helleberg, Lena Specht, Jens Lundgren
    Radiotherapy and Oncology.2021; 158: 175.     CrossRef
  • Prognosis of severe lymphopenia after postoperative radiotherapy in non-small cell lung cancer: Results of a long-term follow up study
    Wang Jing, Yufei Liu, Hui Zhu, James Welsh, Saumil Gandhi, Melenda Jeter, Quynh Nguyen, Aileen B. Chen, Michael O'Reilly, Zhongxing Liao, Joe Y. Chang, Percy Lee, Steven H. Lin
    Clinical and Translational Radiation Oncology.2021; 28: 54.     CrossRef
  • Prognostic value of neutrophils for patients with nasopharyngeal carcinoma
    Lisha Chen, Mengying Li, Ting Xu, Xiufang Qiu, Chuanben Chen
    Laryngoscope Investigative Otolaryngology.2021; 6(2): 219.     CrossRef
  • The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis
    Pim J.J. Damen, Tiuri E. Kroese, Richard van Hillegersberg, Ewoud Schuit, Max Peters, Joost J.C. Verhoeff, Steven H. Lin, Peter S.N. van Rossum
    International Journal of Radiation Oncology*Biology*Physics.2021; 111(4): 936.     CrossRef
  • Prognostic Significance of Circulating Lymphocyte Subsets Before Treatment in Patients with Nasopharyngeal Carcinoma
    De-Song Shen, Chang Yan, Yu Liang, Kai-Hua Chen, Xiao-Dong Zhu
    Cancer Management and Research.2021; Volume 13: 8109.     CrossRef
  • Proton therapy for locally advanced non-small cell lung cancer
    Olsi Gjyshi, Zhongxing Liao
    The British Journal of Radiology.2020;[Epub]     CrossRef
  • Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis
    Jiawen Zhao, Weijia Huang, Yongxian Wu, Yihuan Luo, Bo Wu, Jiwen Cheng, Junqiang Chen, Deyun Liu, Chengyang Li
    Cancer Cell International.2020;[Epub]     CrossRef
  • Prognosis and Risk Factors of Radiation-Induced Lymphopenia in Early-Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy
    Qianqian Zhao, Tingting Li, Gang Chen, Zhaochong Zeng, Jian He
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Prediction of Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Development and Validation of a Pretreatment Nomogram
    Peter S.N. van Rossum, Wei Deng, David M. Routman, Amy Y. Liu, Cai Xu, Yutaka Shiraishi, Max Peters, Kenneth W. Merrell, Christopher L. Hallemeier, Radhe Mohan, Steven H. Lin
    Practical Radiation Oncology.2020; 10(1): e16.     CrossRef
  • Radiation-induced lymphopenia correlates with survival in nasopharyngeal carcinoma: impact of treatment modality and the baseline lymphocyte count
    Xiaoxue Xie, Shenglan Gong, Hekun Jin, Pei Yang, Ting Xu, Yilong Cai, Chengxian Guo, Rong Zhang, Fan Lou, Wenjuan Yang, Hui Wang
    Radiation Oncology.2020;[Epub]     CrossRef
  • Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
    Yasunori Yoshino, Ayumi Taguchi, Maki Takao, Tomoko Kashiyama, Akiko Furusawa, Masaya Uno, Satoshi Okada, Nao Kino, Toshiharu Yasugi
    International Journal of Clinical Oncology.2019; 24(4): 428.     CrossRef
  • Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer
    Michael D. Schad, Sunil W. Dutta, Donald M. Muller, Krishni Wijesooriya, Timothy N. Showalter
    Advances in Radiation Oncology.2019; 4(2): 323.     CrossRef
  • Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era
    Hwa Kyung Byun, Nalee Kim, Hong In Yoon, Seok-Gu Kang, Se Hoon Kim, Jaeho Cho, Jong Geol Baek, Jong Hee Chang, Chang-Ok Suh
    Radiation Oncology.2019;[Epub]     CrossRef
  • Acute severe lymphopenia by radiotherapy is associated with reduced overall survival in hepatocellular carcinoma
    Hwa Kyung Byun, Nalee Kim, Sangjoon Park, Jinsil Seong
    Strahlentherapie und Onkologie.2019; 195(11): 1007.     CrossRef
  • Treatment-Related Lymphopenia Predicts Pathologic Complete Response and Recurrence in Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy
    Qiaoqiao Li, Sha Zhou, Shiliang Liu, Songran Liu, Hong Yang, Lei Zhao, Mengzhong Liu, Yonghong Hu, Mian Xi
    Annals of Surgical Oncology.2019; 26(9): 2882.     CrossRef
  • Assessing the interactions between radiotherapy and antitumour immunity
    Clemens Grassberger, Susannah G. Ellsworth, Moses Q. Wilks, Florence K. Keane, Jay S. Loeffler
    Nature Reviews Clinical Oncology.2019; 16(12): 729.     CrossRef
  • Overview of Hematopoietic Stem Cells in Systemic Cancer Treatment, Aging, Pregnancy, and Radiation Hormesis
    Aleksei N. Shoutko
    Advances in Molecular Imaging.2019; 09(02): 19.     CrossRef
  • Irradiation-Related Lymphopenia for Bone Metastasis from Hepatocellular Carcinoma
    Sangjoon Park, Hwa Kyung Byun, Jinsil Seong
    Liver Cancer.2019; 8(6): 468.     CrossRef
  • Neutropenia during the First Cycle of Induction Chemotherapy Is Prognostic for Poor Survival in Locoregionally Advanced Nasopharyngeal Carcinoma: A Real-World Study in an Endemic Area
    Cheng Xu, Shi-Ping Yang, Yuan Zhang, Ling-Long Tang, Guan-Qun Zhou, Xu Liu, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Lei Chen, Ai-Hua Lin, Ying Sun, Jun Ma
    Cancer Research and Treatment.2018; 50(3): 777.     CrossRef
  • Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors
    Susannah G. Ellsworth
    Advances in Radiation Oncology.2018; 3(4): 512.     CrossRef
  • Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles
    Anne Rodallec, Guillaume Sicard, Raphaelle Fanciullino, Sébastien Benzekry, Bruno Lacarelle, Gerard Milano, Joseph Ciccolini
    Expert Opinion on Drug Metabolism & Toxicology.2018; : 1.     CrossRef
  • 11,663 View
  • 355 Download
  • 61 Web of Science
  • 55 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP