Cancer Research and Treatment

Tumor Lysis Syndrome in a Solid Tumor: A Case Report of a Patient with Invasive Thymoma: Ji Yun Lee, Sung Hee Lim, Ji Young Lee, Ji Hoon Kim, Ki Hong Choi, Keunchil Park, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn; Cancer Res Treat. 2013;45(4):343-348. Published online December 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.4.343

Tumor lysis syndrome (TLS) has rarely been observed in solid tumors. We report on a case of a patient with advanced invasive thymoma who developed tumor lysis syndrome after chemotherapy. The potential complications of TLS should be considered in treatment of extensive thymoma.

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Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis
Larry E Nyanti, Andy Sing Ong Tang, Adam Malik b Ismail, Lee Ping Chew, Tze Shin Leong
Proceedings of Singapore Healthcare.2022;[Epub] CrossRef
Tumor Lysis Syndrome in Patients With Solid Tumors: A Systematic Review of Reported Cases
Riyadh M Alqurashi , Husam H Tamim, Ziyad D Alsubhi, Alyazid A Alzahrani, Emad Tashkandi
Cureus.2022;[Epub] CrossRef
Spontaneous tumour lysis syndrome in cervical cancer
Yu Kyung Kim, Ji Yeon Ham, Won-Kil Lee, Kyung Eun Song
Journal of Obstetrics and Gynaecology.2017; 37(5): 679. CrossRef
Ifosfamide/mesna/paclitaxel

Reactions Weekly.2015; 1547(1): 151. CrossRef
Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature
Aibek E. Mirrakhimov, Alaa M. Ali, Maliha Khan, Aram Barbaryan
Rare Tumors.2014; 6(2): 68. CrossRef

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Systems Biology Approaches to Decoding the Genome of Liver Cancer: Ju-Seog Lee, Ji Hoon Kim, Yun-Yong Park, Gordon B. Mills; Cancer Res Treat. 2011;43(4):205-211. Published online December 27, 2011; DOI: https://doi.org/10.4143/crt.2011.43.4.205

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Molecular classification of cancers has been significantly improved patient outcomes through the implementation of treatment protocols tailored to the abnormalities present in each patient's cancer cells. Breast cancer represents the poster child with marked improvements in outcome occurring due to the implementation of targeted therapies for estrogen receptor or human epidermal growth factor receptor-2 positive breast cancers. Important subtypes with characteristic molecular features as potential therapeutic targets are likely to exist for all tumor lineages including hepatocellular carcinoma (HCC) but have yet to be discovered and validated as targets. Because each tumor accumulates hundreds or thousands of genomic and epigenetic alterations of critical genes, it is challenging to identify and validate candidate tumor aberrations as therapeutic targets or biomarkers that predict prognosis or response to therapy. Therefore, there is an urgent need to devise new experimental and analytical strategies to overcome this problem. Systems biology approaches integrating multiple data sets and technologies analyzing patient tissues holds great promise for the identification of novel therapeutic targets and linked predictive biomarkers allowing implementation of personalized medicine for HCC patients.

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Systems Challenges of Hepatic Carcinomas: A Review
Dhatri Madduru, Johny Ijaq, Sujata Dhar, Saumyadip Sarkar, Naresh Poondla, Partha S. Das, Silvia Vasquez, Prashanth Suravajhala
Journal of Clinical and Experimental Hepatology.2019; 9(2): 233. CrossRef
Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease
Yuan Tian, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Alfred Sze-Lok Cheng
Seminars in Cancer Biology.2013; 23(6): 471. CrossRef
The Impact of Network Medicine in Gastroenterology and Hepatology
György Baffy
Clinical Gastroenterology and Hepatology.2013; 11(10): 1240. CrossRef

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A Locally Advanced Breast Cancer with Difficult Differential Diagnosis of Carcinosarcoma and Atypical Medullary Carcinoma, which had Poor Response to Adriamycin- and Taxane-based Neoadjuvant Chemotherapy: A Case Report: Se Hyun Kim, Hyun Cheol Chung, Jaeheon Jeong, Ji Hoon Kim, Sun Young Rha, Joong Bae Ahn, Nam Hoon Cho, Hei-Cheul Jeung; Cancer Res Treat. 2007;39(3):134-137. Published online September 30, 2007; DOI: https://doi.org/10.4143/crt.2007.39.3.134

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Atypical medullary carcinomas and carcinosarcoma have unique histopathological features. Here we present a case with a breast malignancy that had pathological characteristics of both. A 54-year old patient with a malignant breast mass received 6 cycles of adriamycin-based chemotherapy, followed by 3 cycles of paclitaxel monotherapy, and had a poor clinical response to treatment. A modified radical mastectomy was performed. The pathological diagnosis was complicated by an inability to distinguish between atypical medullary carcinoma and carcinosarcoma. The findings included a tumor that was well-circumscribed, high grade and a syncytial growth pattern as well as biphasic sarcomatous and carcinomatous characteristics. In conclusion, atypical medullary carcinoma and carcinosarcoma of the breast have entirely different prognoses and should be managed differently. Both should be treated by surgical resection, and additional therapy should be considered based on the cancer with the poorer prognosis.

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Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity
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World Journal of Clinical Cases.2025;[Epub] CrossRef
A Rare Case of Primary Carcinosarcoma of the Breast
Maria Kiakou, Maria Tolia, Nektarios Koufopoulos, Konstantinos Tsapakidis, Eleni Arvanitou, Gkikas Konstantinos, Nikolaos Charalambakis, Michalis Nikolaou, Dimitrios Matthaios, Nikolaos Tsoukalas
Forum of Clinical Oncology.2022; 13(1): 48. CrossRef
Carcinosarcoma (Metaplastic Carcinoma) Breast: A Rare and Aggressive Primary – Report of Two Cases with Review of Literature
Gunjesh Kumar Singh, Pragya Singh, KT Bhowmik
Indian Journal of Medical and Paediatric Oncology.2018; 39(03): 400. CrossRef
Carcinosarcoma of the Breast: An Aggressive Subtype of Metaplastic Cancer. Report of a Rare Case in a Young BRCA-1 Mutated Woman
Matteo Ghilli, Donatella M. Mariniello, Giovanni Fanelli, Francesca Cascione, Andrea Fontana, Agostino Cristaudo, Anna Cilotti, Adelaide M. Caligo, Giampiero Manca, Livio Colizzi, Antonio G. Naccarato, Manuela Roncella
Clinical Breast Cancer.2017; 17(1): e31. CrossRef

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