Cancer Research and Treatment

Case Reports

Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy: Jae Heun Chung, Hye Ju Yeo, Hyun Myung Cho, Jin Ook Jang, Byung Min Ye, Gun Yoon, Dong Hoon Shin, Dohyung Kim, Woo Hyun Cho; Cancer Res Treat. 2017;49(1):279-282. Published online June 24, 2016; DOI: https://doi.org/10.4143/crt.2016.125

A 22-year-old woman with a 1-month history of shortness of breath that was treated as a case of tuberculosis and pulmonary embolism was referred to the authors’ hospital. Because of the hemodynamic instability in this patient, venoarterial extracorporeal membrane oxygenation (ECMO) was administered in the intensive care unit. She underwent a pulmonary embolectomy for the treatment of progressive circulatory collapse secondary to a pulmonary embolism. The histopathologic result was consistent with a metastatic choriocarcinoma. Despite the surgical management, persistent refractory cardiogenic shock occurred. Subsequently, the patient was treated with chemotherapy in the presence of ECMO and responded well to chemotherapy. She was discharged after 3 months. This case suggests that metastatic choriocarcinoma should be considered as a differential diagnosis in women of childbearing age presenting with a pulmonary embolism, and ECMO may be beneficial in patients with pulmonary embolism for bridging to surgical embolectomy and chemotherapy.

Citations

Citations to this article as recorded by

Isolated pulmonary artery choriocarcinoma masquerading as pulmonary embolism diagnosed by endovascular biopsy
Simon Doran, Ronan Kernan, Niall McEniff
Radiology Case Reports.2024; 19(8): 3525. CrossRef
Extracorporeal membrane oxygenation in critically ill patients with active hematologic and non-hematologic malignancy: a literature review
Roberto Rabello Filho, Daniel Joelsons, Bruno de Arruda Bravim
Frontiers in Medicine.2024;[Epub] CrossRef
Acute pulmonary tumour embolism and right systolic dysfunction in a hidden intrahepatic cholangiocarcinoma: case report
Alejandra Portillo-Romero, Eric Cuevas-Medina, Maria Jose Santa Ana-Bayona, Santiago Saenz-Ancira, Costantino Mancusi, Megha Agarwal, A Shaheer Ahmed, Federico B Blasi, Polyvios Demetriades, Jonathan Senior
European Heart Journal - Case Reports.2023;[Epub] CrossRef
Advances in the use of ECMO in oncology patient
Xiangnan Teng, Jiali Wu, Jing Liao, Shanling Xu
Cancer Medicine.2023; 12(15): 16243. CrossRef
A rare case of pulmonary artery embolism with choriocarcinoma: A case report and literature review
Pengcheng Wang, Dunqiang Ren, Caihong Guo, Xiaoqian Ding, Yiwei Cao, Peige Zhao, Qiang Wang, Wenjuan Xu
Oncology Letters.2023;[Epub] CrossRef
Extracorporeal Membrane Oxygenator Failure in a Patient With Gestational Trophoblastic Neoplasm: Possible Mechanisms and Considerations in Critical Care
Nathan J. Smith, Beth A. Nance, Lucian A. Durham, Lindsey A. McAlarnen, Erin A. Bishop, M. Tracy Zundel
Journal of Cardiothoracic and Vascular Anesthesia.2022; 36(8): 2583. CrossRef
Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia: A case report
Seung Soo Yoo, Shin Yup Lee, Sun Ha Choi
World Journal of Clinical Cases.2022; 10(25): 8974. CrossRef
Extracorporeal Membrane Oxygenation to Facilitate Chemotherapy—Moving the Goalposts!
Emad A Chishti, Thomas Marsden, Aaron Harris, Zhonglin Hao, Suresh Keshavamurthy
Cureus.2022;[Epub] CrossRef
Dyspnoea unmasked with point of care ultrasound. A Case Report
Priya Ramachandran, Varghese Louis, Uma Devaraj, Kavitha Venkatanarayana, Uma Maheshwari Krishnaswamy
SN Comprehensive Clinical Medicine.2021; 3(5): 1203. CrossRef
Outcomes of extracorporeal membrane oxygenation in adults with active hematologic and nonhematologic malignancy
Chul Park, Ui Won Ko, Ryoung‐Eun Ko, Soo Jin Na, Jeong Hoon Yang, Kyeongman Jeon, Gee Young Suh, Kiick Sung, Yang Hyun Cho
Artificial Organs.2021;[Epub] CrossRef
Acute cardiopulmonary failure in a young woman with high-risk gestational trophoblastic neoplasia: A case of induction chemotherapy during extracorporeal membrane oxygenation
Lindsey A. McAlarnen, Nathan J. Smith, Beth A. Nance, M. Tracy Zundel, Erin A. Bishop
Gynecologic Oncology Reports.2021; 37: 100849. CrossRef
Pulmonary tumor embolism from breast cancer diagnosed by selective aspiration cytology using a Swan-Ganz catheter
Ryohei Aoki, Toyoshi Yanagihara, Hiroshi Mannoji, Syunya Sunami, Nobuhiro Tsuruta, Reiko Yoneda, Makoto Usui
Respiratory Medicine Case Reports.2021; 34: 101527. CrossRef
The Utility of Extracorporeal Membrane Oxygenation in Patients With Hematologic Malignancies: A Literature Review
Praveena Tathineni, Mauna Pandya, Bassem Chaar
Cureus.2020;[Epub] CrossRef
Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review
Atsuna Fukuda, Takeshi Isoda, Naoya Sakamoto, Keisuke Nakajima, Tetsuya Ohta
BMC Pediatrics.2019;[Epub] CrossRef
Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium
Belinda Rivera-Lebron, Michael McDaniel, Kamran Ahrar, Abdulah Alrifai, David M. Dudzinski, Christina Fanola, Danielle Blais, David Janicke, Roman Melamed, Kerry Mohrien, Elizabeth Rozycki, Charles B. Ross, Andrew J. Klein, Parth Rali, Nicholas R. Teman,
Clinical and Applied Thrombosis/Hemostasis.2019;[Epub] CrossRef
Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect
Sheng Wang, Dexi Zhou, Zhenyu Xu, Jing Song, Xueyi Qian, Xiongwen Lv, Jiajie Luan
Current Drug Targets.2019; 20(11): 1180. CrossRef
Pulmonary micro‐tumor emboli resulting in paradoxical emboli: a case report
Louis‐Vincent Morin‐Thibault, Daniel Wiseman, Michelle Fortin, Christian Couture, Steeve Provencher
Pulmonary Circulation.2018; 8(2): 1. CrossRef
Possibility of venoarterial extracorporeal membranous oxygenator being a bridging therapy for hemodynamic deterioration of pulmonary tumor thrombotic microangiopathy prior to initiating chemotherapy
Yoshiaki Iwashita, Takuya Hiramoto, Kei Suzuki, Ryotaro Hashizume, Kazuo Maruyama, Hiroshi Imai
Medicine.2018; 97(37): e12169. CrossRef
Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism
Mei Yang, Li Peng
Medicine.2017; 96(36): e7866. CrossRef
Antineoplastics

Reactions Weekly.2017; 1643(1): 32. CrossRef

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18 Web of Science
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Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma: Jae Heun Chung, Seung Kug Baik, Su-Hee Cho, Seong-Geun Kim; Cancer Res Treat. 2015;47(2):329-333. Published online September 11, 2014; DOI: https://doi.org/10.4143/crt.2013.145

Abstract PDF PubReader ePub

A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine region, sparing the basis pontis. Here, we report on the case of a patient with reversible cerebellar ataxia related to extrapontine myelinolysis without hyponatremia after treatment with cisplatin-based chemotherapy for cholangiocarcinoma and discuss the literature on cerebellar ataxia in patients who underwent recent chemotherapy for malignancy.

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Citations to this article as recorded by

A Rare Case of Osmotic Demyelination Syndrome in Advanced Pancreatic Adenocarcinoma Without Hyponatremia
Konstantinos Baronos, Muhammad Memon
Cureus.2025;[Epub] CrossRef
Osmotic demyelination syndrome in cancer patients: Risk even without rapid sodium correction - a scoping review
Youming Wang, Weibing Jia, Minjia Wang, Xiaoli Yang, Xinli Gao, Yao Zhang
Journal of the Neurological Sciences.2024; 467: 123326. CrossRef
Oncologic Emergencies in the Head and Neck
Carlos Zamora, Mauricio Castillo, Paulo Puac-Polanco, Carlos Torres
Radiologic Clinics of North America.2023; 61(1): 71. CrossRef

11,627 View
87 Download
3 Web of Science
3 Crossref

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