Cancer Research and Treatment

Original Articles

Lung and Thoracic cancer

Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non–Small Cell Lung Cancer: Chaelin Lee, Miso Kim, Dong-Wan Kim, Tae Min Kim, Soyeon Kim, Sun-Wha Im, Yoon Kyung Jeon, Bhumsuk Keam, Ja-Lok Ku, Dae Seog Heo; Cancer Res Treat. 2022;54(1):140-149. Published online May 3, 2021; DOI: https://doi.org/10.4143/crt.2021.385

Abstract PDF Supplementary Material PubReader ePub

Purpose
Epidermal growth factor receptor kinase domain duplication (EGFR-KDD) is a rare and poorly understood oncogenic mutation in non–small cell lung cancer (NSCLC). We aimed to investigate the acquired resistance mechanism of EGFR-KDD against EGFR-TKIs.
Materials and Methods
We identified EGFR-KDD in tumor tissue obtained from a patient with stage IV lung adenocarcinoma and established the patient-derived cell line SNU-4784. We also established several EGFR-KDD Ba/F3 cell lines: EGFR-KDD wild type (EGFR-KDD^WT), EGFR-KDD domain 1 T790M (EGFR-KDD^D1T), EGFR-KDD domain 2 T790M (EGFR-KDD^D2T), and EGFR-KDD both domain T790M (EGFR-KDD^BDT). We treated the cells with EGFR tyrosine kinase inhibitors (TKIs) and performed cell viability assays, immunoblot assays, and ENU (N-ethyl-N-nitrosourea) mutagenesis screening.
Results
In cell viability assays, SNU-4784 cells and EGFR-KDD^WT Ba/F3 cells were sensitive to 2nd generation and 3rd generation EGFR TKIs. In contrast, the T790M-positive EGFR-KDD Ba/F3 cell lines (EGFR-KDD^T790M) were only sensitive to 3rd generation EGFR TKIs. In ENU mutagenesis screening, we identified the C797S mutation in kinase domain 2 of EGFR-KDD^BDT Ba/F3 cells. Based on this finding, we established an EGFR-KDD domain 1 T790M/domain 2 cis-T790M+C797S (EGFR-KDD^T/T+C) Ba/F3 model, which was resistant to EGFR TKIs and anti-EGFR monoclonal antibody combined with EGFR TKIs.
Conclusion
Our study reveals that the T790M mutation in EGFR-KDD confers resistance to 1st and 2nd generation EGFR TKIs, but is sensitive to 3rd generation EGFR TKIs. In addition, we identified that the C797S mutation in kinase domain 2 of EGFR-KDD^T790M mediates a resistance mechanism against 3rd generation EGFR TKIs.

Citations

Citations to this article as recorded by

Colorectal cancer harboring EGFR kinase domain duplication response to EGFR tyrosine kinase inhibitors
Tomohiro Kondo, Osamu Kikuchi, Yoshihiro Yamamoto, Tomohiko Sunami, Yafeng Wang, Keita Fukuyama, Tomoki Saito, Hideto Nakahara, Sachiko Minamiguchi, Masashi Kanai, Atsushi Sueyoshi, Manabu Muto
The Oncologist.2025;[Epub] CrossRef
Virtual Screening and Biological Evaluation of T22306 as a Potent Third-generation EGFR Inhibitor for NSCLC Treatment
Ran Wang, Wei Ruan, Dang Fan, Li Long, Han Zhang, Min Li, Shan Xu, Linxiao Wang
Anti-Cancer Agents in Medicinal Chemistry.2025; 25(15): 1128. CrossRef
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology
Justin J. Kim, Ilse K. Schaeffner, David E. Heppner, Ciric To, Pasi A. Jänne, Tyler S. Beyett, Michael J. Eck
Molecular Pharmacology.2024; 105(2): 97. CrossRef
Tumor-associated Macrophages Mediate Gefitinib Resistance in Lung Cancer through HGF/c-met Signaling Pathway
Xiali Tang, Yu Chen, Demin Jiao, Xiang Liu, Jun Chen, Yongyang Liu, Chunyan Jiang, Qingyong Chen
Anti-Cancer Agents in Medicinal Chemistry.2024; 24(1): 30. CrossRef
Research progress on the role of bypass activation mechanisms in resistance to tyrosine kinase inhibitors in non-small cell lung cancer
Ziyang Jiang, Zhihan Gu, Xiaomin Yu, Tao Cheng, Bofu Liu
Frontiers in Oncology.2024;[Epub] CrossRef
Molecular Targets and Mechanisms of Casein-Derived Tripeptides Ile-Pro-Pro and Val-Pro-Pro on Hepatic Glucose Metabolism
Chenyang Wang, Lin Zheng, Mouming Zhao
Journal of Agricultural and Food Chemistry.2023; 71(48): 18802. CrossRef
Erlotinib

Reactions Weekly.2022; 1907(1): 208. CrossRef

9,790 View
341 Download
6 Web of Science
7 Crossref

Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans: Soo Young Lee, Duck-Woo Kim, Young-Kyoung Shin, Myong Hoon Ihn, Sung Min Lee, Heung-Kwon Oh, Ja-Lok Ku, Seung-Yong Jeong, Jae Bong Lee, Soyeon Ahn, Sungho Won, Sung-Bum Kang; Cancer Res Treat. 2016;48(2):668-675. Published online June 5, 2015; DOI: https://doi.org/10.4143/crt.2014.288

Abstract PDF PubReader ePub

Purpose
Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on family history and clinical features (MMRPredict, PREMM1,2,6, and MMRPro) have been validated only in Western countries. In this study, we propose validating these prediction models in the Korean population.
Materials and Methods
We collected MMR gene analysis data from 188 individuals in the Korean Hereditary Tumor Registry. The probability of gene mutation was calculated using three prediction models, and the overall diagnostic value of each model compared using receiver operator characteristic (ROC) curves and area under the ROC curve (AUC). Quantitative test characteristics were calculated at sensitivities of 90%, 95%, and 98%.
Results
Of the individuals analyzed, 101 satisfied Amsterdam criteria II, and 87 were suspected hereditary nonpolyposis colorectal cancer. MMR mutations were identified in 62 of the 188 subjects (33.0%). All three prediction models showed a poor predictive value of AUC (MMRPredict, 0.683; PREMM1,2,6, 0.709; MMRPro, 0.590). Within the range of acceptable sensitivity (> 90%), PREMM1,2,6 demonstrated higher specificity than the other models.
Conclusion
In the Korean population, overall predictive values of the three models (MMRPredict, PREMM1,2,6, MMRPro) for MMR gene mutations are poor, compared with their performance in Western populations. A new prediction model is therefore required for the Korean population to detect MMR mutation carriers, reflecting ethnic differences in genotype-phenotype associations.

Citations

Citations to this article as recorded by

Performance evaluation of predictive models for detecting MMR gene mutations associated with Lynch syndrome in cancer patients in a Chinese cohort in Taiwan
Fei‐Hung Hung, Hung‐Pin Peng, Chen‐Fang Hung, Ling‐Ling Hsieh, An‐Suei Yang, Yong Alison Wang
International Journal of Cancer.2024; 155(12): 2201. CrossRef
Absence of constitutional MLH1 promoter methylation in Pakistani colorectal cancer patients
Ayesha Azeem, Humaira Naeemi, Noor Muhammad, Asif Loya, Muhammed Aasim Yusuf, Muhammad Usman Rashid
Gene Reports.2024; 36: 101995. CrossRef
Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients
Muhammad Usman Rashid, Humaira Naeemi, Noor Muhammad, Asif Loya, Jan Lubiński, Anna Jakubowska, Muhammed Aasim Yusuf
Hereditary Cancer in Clinical Practice.2019;[Epub] CrossRef
Evaluation of current prediction models for Lynch syndrome: updating the PREMM5 model to identify PMS2 mutation carriers
A. Goverde, M. C. W. Spaander, D. Nieboer, A. M. W. van den Ouweland, W. N. M. Dinjens, H. J. Dubbink, C. J. Tops, S. W. ten Broeke, M. J. Bruno, R. M. W. Hofstra, E. W. Steyerberg, A. Wagner
Familial Cancer.2018; 17(3): 361. CrossRef
Advances in Hereditary Colorectal and Pancreatic Cancers
Meghan L. Underhill, Katharine A. Germansky, Matthew B. Yurgelun
Clinical Therapeutics.2016;[Epub] CrossRef

14,460 View
88 Download
4 Web of Science
5 Crossref

Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades: Il Tae Son, Duck-Woo Kim, Seung-Yong Jeong, Young-Kyoung Shin, Myong Hoon Ihn, Heung-Kwon Oh, Sung-Bum Kang, Kyu Joo Park, Jae Hwan Oh, Ja-Lok Ku, Jae-Gahb Park; Cancer Res Treat. 2016;48(2):605-611. Published online May 26, 2015; DOI: https://doi.org/10.4143/crt.2015.092

Abstract PDF PubReader ePub

Purpose
The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients.
Materials and Methods
Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time.
Results
The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly— period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001).
Conclusion
Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry’s establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.

Citations

Citations to this article as recorded by

Universal Screening for Lynch Syndrome Compared with Pedigree-Based Screening: 10-Year Experience in a Tertiary Hospital
Min Hyun Kim, Duck-Woo Kim, Hye Seung Lee, Su Kyung Bang, Soo Hyun Seo, Kyung Un Park, Heung-Kwon Oh, Sung-Bum Kang
Cancer Research and Treatment.2023; 55(1): 179. CrossRef
Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?
Chun-Kai Liao, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jeng-Fu You, Jy-Ming Chiang
Hereditary Cancer in Clinical Practice.2021;[Epub] CrossRef
Comparison of oncologic outcomes between patients with Lynch syndrome and sporadic microsatellite instability-high colorectal cancer
Il Tae Son, Duck-Woo Kim, Min Hyun Kim, Young-Kyoung Shin, Ja-Lok Ku, Heung-Kwon Oh, Sung-Bum Kang, Seung-Yong Jeong, Kyu Joo Park
Annals of Surgical Treatment and Research.2021; 101(1): 13. CrossRef
Germline Variants in MLH1, MSH2, and MSH6 in Korean Patients with Lynch Syndrome
Kyoung-Jin Park, Dong Kyung Chang, Hee Cheol Kim, Jong-Won Kim
Laboratory Medicine Online.2018; 8(4): 156. CrossRef
Efficacy, functional outcome and post‑operative complications of total abdominal colectomy with ileorectal anastomosis vs. segmental colectomy in hereditary non‑polyposis colorectal cancer
Jie Sun, Mingjie Dong, Xiaoping Xiao
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef

12,389 View
107 Download
4 Web of Science
5 Crossref

Review Article

Biology of SNU Cell Lines: Ja-Lok Ku, Jae-Gahb Park; Cancer Res Treat. 2005;37(1):1-19. Published online February 28, 2005; DOI: https://doi.org/10.4143/crt.2005.37.1.1

Abstract PDF PubReader ePub

SNU (Seoul National University) cell lines have been established from Korean cancer patients since 1982. Of these 109 cell lines have been characterized and reported, i.e., 17 colorectal carcinoma, 12 hepatocellular carcinoma, 11 gastric carcinoma, 12 uterine cervical carcinoma, 17 B-lymphoblastoid cell lines derived from cancer patients, 5 ovarian carcinoma, 3 malignant mixed Mllerian tumor, 6 laryngeal squamous cell carcinoma, 7 renal cell carcinoma, 9 brain tumor, 6 biliary tract, and 4 pancreatic carcinoma cell lines. These SNU cell lines have been distributed to biomedical researchers domestic and worldwide through the KCLB (Korean Cell Line Bank), and have proven to be of value in various scientific research fields. The characteristics of these cell lines have been reported in over 180 international journals by our laboratory and by many other researchers from 1987. In this paper, the cellular and molecular characteristics of SNU human cancer cell lines are summarized according to their genetic and epigenetic alterations and functional analysis.

Citations

Citations to this article as recorded by

The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886
Jiyoung Joan Jang, Myung-Ju Lee, Myung-Shin Lee, Jinjong Myoung, Hwi-Ho Lee, Byung-Han Choi, Enkhjin Saruuldalai, Yuh-Seog Jung, Hyun-Sung Lee, Yeochan Kim, TaeJin Ahn, Jong-Lyul Park, Seon-Young Kim, Gaeul Park, Sang-Jae Park, Sung-Hoon Kim, Ji-Hoon Kim,
Cellular and Molecular Life Sciences.2025;[Epub] CrossRef
HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of Carcinogenesis
Jane Shen-Gunther, Acarizia Easley
Viruses.2024; 16(6): 975. CrossRef
Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy
Ozen Leylek, Megan E. Honeywell, Michael J. Lee, Michael T. Hemann, Gulnihal Ozcan
Gastric Cancer.2024; 27(6): 1201. CrossRef
Newcastle disease virus harboring the PTEN gene inhibits pancreatic cancer growth by inhibiting PI3K/AKT/mTOR signaling and activating apoptosis
Seonhee Kim, Bo-Kyoung Jung, Jinju Kim, Joo Hee Jeon, Sung Hoon Jang, Minsoo Kim, Cuk-Seong Kim, Hyun Jang
Molecular Therapy: Oncology.2024; 32(4): 200898. CrossRef
Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases
Annie Yang, Zhifang Zhang, Shyambabu Chaurasiya, Anthony K Park, Audrey Jung, Jianming Lu, Sang-In Kim, Saul Priceman, Yuman Fong, Yanghee Woo
Journal for ImmunoTherapy of Cancer.2023; 11(4): e006280. CrossRef
In Vitro Study on AI‐PRS Enabled Precision Cocktail Drugs Design for Treating Human Colorectal Carcinoma
Hsin‐Yu Yang, Venkanagouda S. Goudar, Yi‐Chi Hung, Chih‐Hsuan Ouyang, Masturah Bte Mohd Abdul Rashid, Liang‐Yi Juo, Jen‐Kuei Wu, Ya‐Wen Cheng, Po‐Li Wei, Huey‐En Tzeng, Jeng‐Kai Jiang, Edward Kai‐Hua Chow, Chih‐Yung Yang, Chih‐Ming Ho, Yun Yen, Fan‐Gang T
Advanced Therapeutics.2023;[Epub] CrossRef
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
Valentina K. Todorova, Stephanie D. Byrum, Samuel G. Mackintosh, Azemat Jamshidi-Parsian, Allen J. Gies, Charity L. Washam, Samir V. Jenkins, Timothy Spiva, Emily Bowman, Nathan S. Reyna, Robert J. Griffin, Issam Makhoul
International Journal of Molecular Sciences.2023; 24(17): 13098. CrossRef
Peritoneal-directed chimeric oncolytic virus CF17 prevents malignant ascites and improves survival in gastric cancer peritoneal metastases
Annie Yang, Zhifang Zhang, Shyambabu Chaurasiya, Anthony K. Park, Jianming Lu, Sang-In Kim, Hannah Valencia, Yuman Fong, Yanghee Woo
Molecular Therapy - Oncolytics.2023; 31: 100734. CrossRef
Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition
Raghav Sundar, Kie-Kyon Huang, Vikrant Kumar, Kalpana Ramnarayanan, Deniz Demircioglu, Zhisheng Her, Xuewen Ong, Zul Fazreen Bin Adam Isa, Manjie Xing, Angie Lay-Keng Tan, David Wai Meng Tai, Su Pin Choo, Weiwei Zhai, Jia Qi Lim, Meghna Das Thakur, Lucian
Gut.2022; 71(7): 1277. CrossRef
Regulation of GTPase function by autophosphorylation
Christian W. Johnson, Hyuk-Soo Seo, Elizabeth M. Terrell, Moon-Hee Yang, Fenneke KleinJan, Teklab Gebregiworgis, Genevieve M.C. Gasmi-Seabrook, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Puspalata Bashyal, Olesja Popow, Joao A. Paulo, Andrea Liu, Carl
Molecular Cell.2022; 82(5): 950. CrossRef
Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric cancer cells
Min Hee Yang, Seung Ho Baek, Sun Tae Hwang, Jae‐Young Um, Kwang Seok Ahn
Phytotherapy Research.2022; 36(6): 2449. CrossRef
Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma
Sojin Kim, Soo-Ji Park, Tamrin Chowdhury, Jeong-Im Hong, Jinhee Ahn, Tae Yeong Jeong, Hyeon Jong Yu, Young-Kyoung Shin, Ja-Lok Ku, Jong Bae Park, Junho K. Hur, Hwajin Lee, Kyoungmi Kim, Chul‑Kee Park
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Comparative Study of Autophagy in Oxaliplatin-Sensitive and Resistant SNU-C5 Colon Cancer Cells
Sun-Jin Boo, Mei Jing Piao, Kyoung Ah Kang, Ao Xuan Zhen, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Seung Joo Lee, Seung Eun Song, Jin Won Hyun
Biomolecules & Therapeutics.2022; 30(5): 447. CrossRef
BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment
Stephanie Busche, Katharina John, Franziska Wandrer, Florian W. R. Vondran, Ulrich Lehmann, Heiner Wedemeyer, Frank Essmann, Klaus Schulze-Osthoff, Heike Bantel
Cell Death & Disease.2021;[Epub] CrossRef
The role of transforming growth factor β in upper gastrointestinal cancers: A systematic review
Linde M. Veen, Tim L.P. Skrabanja, Sarah Derks, Tanja D. de Gruijl, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven
Cancer Treatment Reviews.2021; 100: 102285. CrossRef
Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses
Yanping Yang, Jaclyn E. McCloskey, Huan Yang, Janusz Puc, Yago Alcaina, Yogindra Vedvyas, Angel A. Gomez Gallegos, Elizabeth Ortiz-Sánchez, Elisa de Stanchina, Irene M. Min, Eric von Hofe, Moonsoo M. Jin
Cancer Immunology Research.2021; 9(10): 1158. CrossRef
Identification and Functional Characterization of Two Noncoding RNAs Transcribed from Putative Active Enhancers in Hepatocellular Carcinoma
Ye-Eun Lee, Jiyeon Lee, Yong Sun Lee, Jiyoung Joan Jang, Hyeonju Woo, Hae In Choi, Young Gyu Chai, Tae-Kyung Kim, TaeSoo Kim, Lark Kyun Kim, Sun Shim Choi
Molecules and Cells.2021; 44(9): 658. CrossRef
TDP1 and TOP1 Modulation in Olaparib-Resistant Cancer Determines the Efficacy of Subsequent Chemotherapy
Jin Won Kim, Ahrum Min, Seock-Ah Im, Hyemin Jang, Yu Jin Kim, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Keun Wook Lee, Do-Youn Oh, Jee-Hyun Kim, Yung-Jue Bang
Cancers.2020; 12(2): 334. CrossRef
ErbB3, a possible prognostic factor of head and neck squamous cell carcinoma
Heejin Kim, Joo Yeon Choi, Yoon Chan Rah, Jae-Cheul Ahn, Hyunchul Kim, Woo-Jin Jeong, Soon-Hyun Ahn
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2020; 129(4): 377. CrossRef
Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells
María A. Rodríguez-Hernández, Raquel Chapresto-Garzón, Miryam Cadenas, Elena Navarro-Villarán, María Negrete, Miguel A. Gómez-Bravo, Victor M. Victor, Francisco J. Padillo, Jordi Muntané
Cell Death & Disease.2020;[Epub] CrossRef
PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer
Kui-Jin Kim, Ji-Won Kim, Ji Hea Sung, Koung Jin Suh, Ji Yun Lee, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee, Hark Kyun Kim, Keun-Wook Lee
Scientific Reports.2020;[Epub] CrossRef
RhoA and Rac1 in Liver Cancer Cells: Induction of Overexpression Using Mechanical Stimulation
Sharda Yadav, Navid Kashaninejad, Nam-Trung Nguyen
Micromachines.2020; 11(8): 729. CrossRef
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype
Anees Khatib, Balakrishnan Solaimuthu, Michal Ben Yosef, Areej Abu Rmaileh, Mayur Tanna, Gidi Oren, Michal Schlesinger Frisch, Jonathan H. Axelrod, Michal Lichtenstein, Yoav D. Shaul
Proceedings of the National Academy of Sciences.2020; 117(35): 21420. CrossRef
CircRNA CircRIMS Acts as a MicroRNA Sponge to Promote Gastric Cancer Metastasis
Jun Lin, Yi Zhang, Xianchang Zeng, Chaorong Xue, Xu Lin
ACS Omega.2020; 5(36): 23237. CrossRef
Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
Miso Lee, Kyung-Hun Lee, Ahrum Min, Jeongeun Kim, Seongyeong Kim, Hyemin Jang, Jee Min Lim, So Hyeon Kim, Dong-Hyeon Ha, Won Jae Jeong, Koung Jin Suh, Yae-Won Yang, Tae Yong Kim, Do-Youn Oh, Yung-Jue Bang, Seock-Ah Im
Cancer Research and Treatment.2019; 51(2): 451. CrossRef
Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations
Ye‐Lim Park, Hwang‐Phill Kim, Young‐Won Cho, Dong‐Wook Min, Seul‐Ki Cheon, Yoo Joo Lim, Sang‐Hyun Song, Sung Jin Kim, Sae‐Won Han, Kyu Joo Park, Tae‐You Kim
International Journal of Cancer.2019; 144(2): 389. CrossRef
NFATC3–PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines
Jee-Eun Jang, Hwang-Phill Kim, Sae-Won Han, Hoon Jang, Si-Hyun Lee, Sang-Hyun Song, Duhee Bang, Tae-You Kim
Cancer Research and Treatment.2019; 51(1): 391. CrossRef
Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells
Mamiko Imanishi, Yoshiyuki Yamamoto, Xiaoxuan Wang, Akinori Sugaya, Mitsuaki Hirose, Shinji Endo, Yukikazu Natori, Kenji Yamato, Ichinosuke Hyodo
Cancer Science.2019; 110(2): 639. CrossRef
Cytotoxicity of Human Hepatic Intrasinusoidal CD56bright Natural Killer Cells against Hepatocellular Carcinoma Cells
Shin Hwang, Jaeseok Han, Ji-Seok Baek, Eunyoung Tak, Gi-Won Song, Sung-Gyu Lee, Dong-Hwan Jung, Gil-Chun Park, Chul-Soo Ahn, Nayoung Kim
International Journal of Molecular Sciences.2019; 20(7): 1564. CrossRef
Cytolytic Activity of Effector T-lymphocytes Against Hepatocellular Carcinoma is Improved by Dendritic Cells Pulsed with Pooled Tumor Antigens
Thaweesak Chieochansin, Chutamas Thepmalee, Janya Grainok, Mutita Junking, Pa-thai Yenchitsomanus
Scientific Reports.2019;[Epub] CrossRef
Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer
S H Song, M S Jeon, J W Nam, J K Kang, Y J Lee, J Y Kang, H P Kim, S W Han, G H Kang, T Y Kim
Oncogene.2018; 37(8): 993. CrossRef
Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells
Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, Kyong-Ah Yoon, Hiromu Suzuki
PLOS ONE.2018; 13(2): e0193275. CrossRef
Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models
Eun Ju Shin, Hyo-Kyoung Choi, Mi Jeong Sung, Jae Ho Park, Min-Yu Chung, Sangwon Chung, Jin-Taek Hwang
Biochemical Pharmacology.2018; 152: 60. CrossRef
Cyclin E overexpression confers resistance to the CDK4/6 specific inhibitor palbociclib in gastric cancer cells
Ahrum Min, Jung Eun Kim, Yu-Jin Kim, Jee Min Lim, Seongyeong Kim, Jin Won Kim, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Yung-Jue Bang, Seock-Ah Im
Cancer Letters.2018; 430: 123. CrossRef
Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells
Seul‐Ki Cheon, Hwang‐Phill Kim, Ye‐Lim Park, Jee‐Eun Jang, Yoojoo Lim, Sang‐Hyun Song, Sae‐Won Han, Tae‐You Kim
Molecular Oncology.2018; 12(8): 1398. CrossRef
Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers
Zhihao Wu, Hong-Fen Guo, Hong Xu, Nai-Kong V. Cheung
Molecular Cancer Therapeutics.2018; 17(10): 2164. CrossRef
Keratin 19 Expression in Hepatocellular Carcinoma Is Regulated by Fibroblast-Derived HGF via a MET-ERK1/2-AP1 and SP1 Axis
Hyungjin Rhee, Hye-Young Kim, Ji-Hye Choi, Hyun Goo Woo, Jeong Eun Yoo, Ji Hae Nahm, Jin-Sub Choi, Young Nyun Park
Cancer Research.2018; 78(7): 1619. CrossRef
Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer
Andrea J. Savio, Bharati Bapat
Epigenetics.2017; 12(6): 441. CrossRef
Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
Cheng Wen Yao, Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Pattage Madushan Dilhara Jayatissa Fernando, Min Chang Oh, Jeong Eon Park, Kristina Shilnikova, Soo-Young Na, Seung Uk Jeong, Sun-Jin Boo, Jin Won Hyun
Biomolecules & Therapeutics.2017; 25(3): 315. CrossRef
AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
Ahrum Min, Seock-Ah Im, Hyemin Jang, Seongyeong Kim, Miso Lee, Debora Keunyoung Kim, Yaewon Yang, Hee-Jun Kim, Kyung-Hun Lee, Jin Won Kim, Tae-Yong Kim, Do-Youn Oh, Jeff Brown, Alan Lau, Mark J. O'Connor, Yung-Jue Bang
Molecular Cancer Therapeutics.2017; 16(4): 566. CrossRef
Epithelial–mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells
Paulina Grygielewicz, Barbara Dymek, Anna Bujak, Pawel Gunerka, Aleksandra Stanczak, Monika Lamparska-Przybysz, Maciej Wieczorek, Karolina Dzwonek, Daria Zdzalik
Gastric Cancer.2016; 19(1): 53. CrossRef
Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability
Jiyeon Yun, Sang-Hyun Song, Jee-Youn Kang, Jinah Park, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim
Nucleic Acids Research.2016; 44(2): 558. CrossRef
Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer
Mi-Seong Jeon, Sang-Hyun Song, Jiyeon Yun, Jee-Youn Kang, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim
Cancer Research and Treatment.2016; 48(2): 676. CrossRef
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation
Jae Won Chang, Seung-Nam Jung, Ju-Hee Kim, Geun-Ae Shim, Hee Sung Park, Lihua Liu, Jin Man Kim, Jongsun Park, Bon Seok Koo
Scientific Reports.2016;[Epub] CrossRef
C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties
Kai-Yu Ng, Stella Chai, Man Tong, Xin-Yuan Guan, Chi-Ho Lin, Yick-Pang Ching, Dan Xie, Alfred Sze-Lok Cheng, Stephanie Ma
Oncotarget.2016; 7(17): 24005. CrossRef
Bone morphogenetic protein-9 is a potent growth inhibitor of hepatocellular carcinoma and reduces the liver cancer stem cells population
Jae Woo Jung, So-Mi Yoon, Subin Kim, Yun-Hui Jeon, Byung-Hak Yoon, Su-Geun Yang, Min Kyoung Kim, Senyon Choe, Mario Meng-Chiang Kuo
Oncotarget.2016; 7(45): 73754. CrossRef
Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage–Induced Senescence Program in Gastric Cancer
Paola Francica, Lluís Nisa, Daniel M. Aebersold, Rupert Langer, Friedhelm Bladt, Andree Blaukat, Deborah Stroka, María Rodríguez Martínez, Yitzhak Zimmer, Michaela Medová
Clinical Cancer Research.2016; 22(21): 5322. CrossRef
Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL
Su-Hoon Lee, Suh-Kyung Hyun, Hak-Bong Kim, Chi-Dug Kang, Sun-Hee Kim
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics.2016; 24(6): 495. CrossRef
GAGE12 mediates human gastric carcinoma growth and metastasis
Eun Kyung Lee, Kyung‐A. Song, Ji‐Hye Chae, Kyoung‐Mee Kim, Seok‐Hyung Kim, Myung‐Soo Kang
International Journal of Cancer.2015; 136(10): 2284. CrossRef
Identification of Long-Range Epigenetic Silencing on Chromosome 15q25 and Its Clinical Implication in Gastric Cancer
Jee-Youn Kang, Sang-Hyun Song, Jiyeon Yun, Mi-Seong Jeon, Yongjun Cha, Si-Hyun Lee, Hwang-Phill Kim, Eun-Goo Jeong, Sae-Won Han, Nam-Yun Cho, Myeong Cherl Kook, Gyeong Hoon Kang, Tae-You Kim
The American Journal of Pathology.2015; 185(3): 666. CrossRef
Targeting HIF1α Peri-operatively Increased Post-surgery Survival in a Tongue Cancer Animal Model
Soon-Hyun Ahn, Joo Yeon Choi, Dong Wook Kim, Doh Young Lee, Eun-Hui Jeon, Woo-Jin Jeong, Jin Ho Paik
Annals of Surgical Oncology.2015; 22(9): 3041. CrossRef
Combined targeting of high‐mobility group box‐1 and interleukin‐8 to control micrometastasis potential in gastric cancer
Hye Won Chung, Sunphil Jang, Hoguen Kim, Jong‐Baeck Lim
International Journal of Cancer.2015; 137(7): 1598. CrossRef
Evaluation of Lapatinib Powder-Entrapped Biodegradable Polymeric Microstructures Fabricated by X-Ray Lithography for a Targeted and Sustained Drug Delivery System
Eun-Goo Jeong, Hyung Yoo, Byeonghwa Song, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim, Dong-Il Cho
Materials.2015; 8(2): 519. CrossRef
Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition
Namgyu Lee, Jung-Hee Kwon, Young Bae Kim, Seong-Hoon Kim, Sung Jin Park, Weiguang Xu, Hoe-Yune Jung, Kyong-Tai Kim, Hee Jung Wang, Kwan Yong Choi
Oncotarget.2015; 6(30): 30130. CrossRef
Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-κB signaling and is associated with metastasis and poor prognosis in gastric cancer patients
Jian Li, Zhijuan Deng, Zhu Wang, Dong Wang, Longjuan Zhang, Qiao Su, Yingrong Lai, Bin Li, Zexing Luo, Xu Chen, Yu Chen, Xiaohui Huang, Jieyi Ma, Wenjian Wang, Jiong Bi, Xinyuan Guan
Oncotarget.2015; 6(10): 8323. CrossRef
Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development
Fung-Yu Huang, Danny Ka-Ho Wong, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
Oncotarget.2015; 6(33): 34941. CrossRef
Novel fusion transcripts in human gastric cancer revealed by transcriptome analysis
H-P Kim, G-A Cho, S-W Han, J-Y Shin, E-G Jeong, S-H Song, W-C Lee, K-H Lee, D Bang, J-S Seo, J-Il Kim, T-Y Kim
Oncogene.2014; 33(47): 5434. CrossRef
p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines
Sung-Ung Moon, Jin Won Kim, Ji Hea Sung, Mi Hyun Kang, Se-Hyun Kim, Hyun Chang, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee
Cancer Research and Treatment.2014; 47(3): 501. CrossRef
Decreased Mitochondrial OGG1 Expression is Linked to Mitochondrial Defects and Delayed Hepatoma Cell Growth
Young-Kyoung Lee, Hwang-Guem Youn, Hee-Jung Wang, Gyesoon Yoon
Molecules and Cells.2013; 35(6): 489. CrossRef
Anti-cancer effect of a quinoxaline derivative GK13 as a transglutaminase 2 inhibitor
Seon-Hyeong Lee, Nayeon Kim, Se-Jin Kim, Jaewhan Song, Young-Dae Gong, Soo-Youl Kim
Journal of Cancer Research and Clinical Oncology.2013; 139(8): 1279. CrossRef
Large-scale profiling and identification of potential regulatory mechanisms for allelic gene expression in colorectal cancer cells
Robin Dong-Woo Lee, Min-Young Song, Jong-Keuk Lee
Gene.2013; 512(1): 16. CrossRef
Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells
Y Suh, C-H Yoon, R-K Kim, E-J Lim, Y S Oh, S-G Hwang, S An, G Yoon, M C Gye, J-M Yi, M-J Kim, S-J Lee
Oncogene.2013; 32(41): 4873. CrossRef
p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax
CHAE WON KIM, JING NAN LU, SE-IL GO, JI HYUN JUNG, SANG MI YI, JAE-HOON JEONG, YOUNG-SOOL HAH, MYUNG SHIN HAN, JEONG WOO PARK, WON SUP LEE, YOUNG JOO MIN
International Journal of Oncology.2013; 43(5): 1495. CrossRef
RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib
Ahrum Min, Seock-Ah Im, Young-Kwang Yoon, Sang-Hyun Song, Hyun-Jin Nam, Hyung-Seok Hur, Hwang-Phill Kim, Kyung-Hun Lee, Sae-Won Han, Do-Youn Oh, Tae-You Kim, Mark J. O'Connor, Woo-Ho Kim, Yung-Jue Bang
Molecular Cancer Therapeutics.2013; 12(6): 865. CrossRef
Antitumor Activity of Saracatinib (AZD0530), a c-Src/Abl Kinase Inhibitor, Alone or in Combination with Chemotherapeutic Agents in Gastric Cancer
Hyun-Jin Nam, Seock-Ah Im, Do-Youn Oh, Paul Elvin, Hwang-Phill Kim, Young-Kwang Yoon, Ahrum Min, Sang-Hyun Song, Sae-Won Han, Tae-You Kim, Yung-Jue Bang
Molecular Cancer Therapeutics.2013; 12(1): 16. CrossRef
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer
Hyun-A Kim, Bon-Kyoung Koo, Ji-Hoon Cho, Yoon-Young Kim, Jinwoo Seong, Hee Jin Chang, Young Min Oh, Daniel E. Stange, Jae-Gahb Park, Daehee Hwang, Young-Yun Kong
Journal of Clinical Investigation.2012; 122(9): 3248. CrossRef
Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells
Young-Kwang Yoon, Hwang-Phill Kim, Sang-Hyun Song, Sae-Won Han, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Kim
Cancer Letters.2012; 316(1): 77. CrossRef
The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines
Hyun-Jin Nam, Hwang-Phill Kim, Young-Kwang Yoon, Sang-Hyun Song, Ah-Rum Min, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang
Investigational New Drugs.2012; 30(6): 2148. CrossRef
Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases
Jun-Xiang Zhang, Da-Qiang Li, Aiwu Ruth He, Mona Motwani, Vasilis Vasiliou, Jeyanthy Eswaran, Lopa Mishra, Rakesh Kumar
Hepatology.2012; 55(6): 1840. CrossRef
Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric cancer
Young-Kwang Yoon, Seock-Ah Im, Ahrum Min, Hwang-Phill Kim, Hyung-Seok Hur, Kyung-Hun Lee, Sae-Won Han, Sang-Hyun Song, Do Youn Oh, Tae-You Kim, Woo Ho Kim, Yung-Jue Bang
Cancer Letters.2012; 321(2): 128. CrossRef
Heterodimerization of Glycosylated Insulin-Like Growth Factor-1 Receptors and Insulin Receptors in Cancer Cells Sensitive to Anti-IGF1R Antibody
Jun Gyu Kim, Min Jueng Kang, Young-Kwang Yoon, Hwang-Phill Kim, Jinah Park, Sang-Hyun Song, Sae-Won Han, Jong-Wan Park, Gyeong Hoon Kang, Keon Wook Kang, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Eugene C. Yi, Tae-You Kim, Frank T. Kolligs
PLoS ONE.2012; 7(3): e33322. CrossRef
NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations
EUNJU PARK, JINAH PARK, SAE-WON HAN, SEOCK-AH IM, TAE-YOU KIM, DO-YOUN OH, YUNG-JUE BANG
International Journal of Oncology.2012; 40(4): 1259. CrossRef
Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis
Sunyoung Chae, Young Bae Kim, Jong-Soo Lee, Hyeseong Cho
American Journal of Physiology-Gastrointestinal and Liver Physiology.2012; 302(9): G1016. CrossRef
Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer
Hyun-Jin Nam, Keith A. Ching, Julie Kan, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, James G. Christensen, Do-Youn Oh, Yung-Jue Bang
Molecular Cancer Therapeutics.2012; 11(2): 439. CrossRef
Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells
Sung-Chul Lim, Hong-Quan Duong, Jeong Eun Choi, Tae-Bum Lee, Ju-Hee Kang, Seung Hyun Oh, Song Iy Han
Carcinogenesis.2011; 32(5): 723. CrossRef
Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects
June-Hyung Kim, Ei-Lyoung Kim, Young-Kyoung Lee, Chan-Bae Park, Bong-Wan Kim, Hee-Jung Wang, Chang-Hwan Yoon, Su-Jae Lee, Gyesoon Yoon
Experimental Cell Research.2011; 317(8): 1108. CrossRef
Antitumor activity of NVP‐AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins
Kyung‐Hun Lee, Ju‐Hee Lee, Sae‐Won Han, Seock‐Ah Im, Tae‐You Kim, Do‐Youn Oh, Yung‐Jue Bang
Cancer Science.2011; 102(7): 1388. CrossRef
Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer
Hyun-Jin Nam, Hwang-Phill Kim, Young-Kwang Yoon, Hyung-Seok Hur, Sang-Hyun Song, Maeng-Sup Kim, Gwan-Sun Lee, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang
Cancer Letters.2011; 302(2): 155. CrossRef
Inhibition of Histone Deacetylase 10 Induces Thioredoxin-Interacting Protein and Causes Accumulation of Reactive Oxygen Species in SNU-620 Human Gastric Cancer Cells
Ju-Hee Lee, Eun-Goo Jeong, Moon-Chang Choi, Sung-Hak Kim, Jung-Hyun Park, Sang-Hyun Song, Jinah Park, Yung-Jue Bang, Tae-You Kim
Molecules and Cells.2010; 30(2): 107. CrossRef
Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells
Young-Kwang Yoon, Hwang-Phill Kim, Sae-Won Han, Hyung-Seok Hur, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Kim
Molecular Cancer Therapeutics.2009; 8(9): 2526. CrossRef
Adaptive and Robust Methods of Reconstruction (ARMOR) for Thermoacoustic Tomography
Yao Xie, Yao Xie, Bin Guo, Bin Guo, Jian Li, Geng Ku, L.V. Wang
IEEE Transactions on Biomedical Engineering.2008; 55(12): 2741. CrossRef
Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors
Jung-Hyun Park, Sung-Hak Kim, Moon-Chang Choi, Juhee Lee, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Kim
Biochemical and Biophysical Research Communications.2008; 368(2): 318. CrossRef
Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers
Yeonjoo Jung, Jinah Park, Yung-Jue Bang, Tae-You Kim
Laboratory Investigation.2008; 88(2): 153. CrossRef
Enzastaurin, a Protein Kinase Cβ Inhibitor, Suppresses Signaling through the Ribosomal S6 Kinase and Bad Pathways and Induces Apoptosis in Human Gastric Cancer Cells
Keun-Wook Lee, Sang Gyun Kim, Hwang-Phill Kim, Euna Kwon, Jiran You, Hyung-Jun Choi, Jung-Hyun Park, Byeong-Cheol Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Yung-Jue Bang
Cancer Research.2008; 68(6): 1916. CrossRef
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy
Yeonjoo Jung, Jinah Park, Tai Young Kim, Jung-Hyun Park, Hyun-Soon Jong, Seock-Ah Im, Keith D. Robertson, Yung-Jue Bang, Tae-You Kim
Journal of Molecular Medicine.2007; 85(10): 1137. CrossRef
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer
M Nojima, H Suzuki, M Toyota, Y Watanabe, R Maruyama, S Sasaki, Y Sasaki, H Mita, N Nishikawa, K Yamaguchi, K Hirata, F Itoh, T Tokino, M Mori, K Imai, Y Shinomura
Oncogene.2007; 26(32): 4699. CrossRef
Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells
Ju-Hee Lee, Jung-Hyun Park, Yeonjoo Jung, Jee-Hyun Kim, Hyun-Soon Jong, Tae-You Kim, Yung-Jue Bang
Molecular Cancer Therapeutics.2006; 5(12): 3085. CrossRef

34,559 View

519 Download

87 Crossref

First

Prev

Page of 1

Next

Last

Search