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2 "In Yong Whang"
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Case Report
PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers
Hye Sung Won, Eun Deok Chang, Sae Jung Na, In Yong Whang, Dong Soo Lee, Sun Hyong You, Yong Seok Kim, Jeong Soo Kim
Cancer Res Treat. 2019;51(1):402-407.   Published online February 27, 2018
DOI: https://doi.org/10.4143/crt.2017.579
AbstractAbstract PDFPubReaderePub
PTEN hamartoma tumor syndrome is a spectrum of disorders characterized by unique phenotypic features including multiple hamartomas caused by mutations of the tumor suppressor gene PTEN. Cowden syndrome and Bannayan–Riley–Ruvalcaba syndrome are representative diseases, and both have several common clinical features and differences. Because PTEN mutations are associated with an increased risk of malignancy including breast, thyroid, endometrial, and renal cancers, cancer surveillance is an important element of disease management. We report a germline mutation of the PTEN (c.723dupT, exon 7) identified in a young woman with a simultaneous occurrence of breast cancer, dermatofibrosarcoma protuberans, and follicular neoplasm. This case suggests that it is critical for clinicians to recognize the phenotypic features associated with these syndromes to accurately diagnose them and provide preventive care.

Citations

Citations to this article as recorded by  
  • Breast Cancer with a Newly Diagnosed Variant in the PTEN Gene: A Case Report
    Yuka Maeda, Tatsuhiko Ikeda, Ayana Sato, Akiko Matsumoto, Hiromitsu Jinno
    Surgical Case Reports.2025; 11(1): n/a.     CrossRef
  • Synchronous and metachronous thyroid cancer, breast cancer, and melanoma in a premenopausal patient with Cowden syndrome
    Belinda Asare, Babita Panigrahi
    Radiology Case Reports.2023; 18(5): 1918.     CrossRef
  • Molecular Action of Herbal Antioxidants in Regulation of Cancer Growth: Scope for Novel Anticancer Drugs
    Manjula Vinayak
    Nutrition and Cancer.2018; 70(8): 1199.     CrossRef
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Original Article
Effect of Granisetron Plus Dexamethasone in the Prevention of Delayed Nausea and Vomiting
Jeong Woo Shim, Yong Seop Lee, Heung Up Kim, Geong Won Jung, Yeong Ho Park, Se Ho Chang, Jin Yong Whang, Jeong Soon Jang, Jong Seok Lee
J Korean Cancer Assoc. 1997;29(4):690-699.
AbstractAbstract PDF
BACKGROUND
Granisetron, a new 5-HT3 receptor antagonist, was reported as a highly effective antiemetics, especially in combination with dexamethasone, in the prevention of acute emesis induced by cisplatin. But there is lack of data about effectiveness in the prevention of delayed emesis. In this study, the efficacy of granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin was evaluated.
MATERIALS AND METHODS
Sixty-four patients who were to receive high-dose cisplatin containing chemotherapy regimen were enrolled in this study. They were received 20 mg of dexamethasone and 3 mg of granisetron at 30 min and 10 minutes prior to cisplatin infusion, respectively. They were monitored for 5 days, first 24 hours for acute nausea/ vomiting and the subsequent 4 days for delayed nausea/vomiting. Antiemetic effect of granisetron was evaluated according to the criteria of Italian Group of Antiemetic Research.
RESULTS
Control of delayed nausea and vomiting was achieved in 58% and 84%, respectively. Eastern Cooperative Oncology Group performance status was a statistically significant prognostic factor for control of acute vomiting and delayed nausea/vomiting. There were no stastically significant differences between control of delayed nausea/ vomiting and other prognostic factors, including sex, age, and prior history of cisplatin therapy. The antiemetic effect was greater in the patients who had controled acute nausea/ vomiting than those who had not.
CONCLUSION
Granisetron plus dexamethasone is an excellent regimen in the control of not only acute emesis but also delayed emesis induced by high-dose cisplatin chemotherapy.
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