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5 "In Kyu Park"
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Lung and Thoracic cancer
The Role of Adjuvant Therapy Following Surgical Resection of Small Cell Lung Cancer: A Multi-Center Study
Seong Yong Park, Samina Park, Geun Dong Lee, Hong Kwan Kim, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Tae Hee Hong, Yong Soo Choi, Jhingook Kim, Jong Ho Cho, Young Mog Shim, Jae Ill Zo, Kwon Joong Na, In Kyu Park, Chang Hyun Kang, Young-Tae Kim, Byung Jo Park, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik
Cancer Res Treat. 2023;55(1):94-102.   Published online June 9, 2022
DOI: https://doi.org/10.4143/crt.2022.290
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This multi-center, retrospective study was conducted to evaluate the long-term survival in patients who underwent surgical resection for small cell lung cancer (SCLC) and to identify the benefit of adjuvant therapy following surgery.
Materials and Methods
The data of 213 patients who underwent surgical resection for SCLC at four institutions were retrospectively reviewed. Patients who received neoadjuvant therapy or an incomplete resection were excluded.
Results
The mean patient age was 65.29±8.93 years, and 184 patients (86.4%) were male. Lobectomies and pneumonectomies were performed in 173 patients (81.2%), and 198 (93%) underwent systematic mediastinal lymph node dissections. Overall, 170 patients (79.8%) underwent adjuvant chemotherapy, 42 (19.7%) underwent radiotherapy to the mediastinum, and 23 (10.8%) underwent prophylactic cranial irradiation. The median follow-up period was 31.08 months (interquartile range, 13.79 to 64.52 months). The 5-year overall survival (OS) and disease-free survival were 53.4% and 46.9%, respectively. The 5-year OS significantly improved after adjuvant chemotherapy in all patients (57.4% vs. 40.3%, p=0.007), and the survival benefit of adjuvant chemotherapy was significant in patients with negative node pathology (70.8% vs. 39.7%, p=0.004). Adjuvant radiotherapy did not affect the 5-year OS (54.6% vs. 48.5%, p=0.458). Age (hazard ratio [HR], 1.032; p=0.017), node metastasis (HR, 2.190; p < 0.001), and adjuvant chemotherapy (HR, 0.558; p=0.019) were associated with OS.
Conclusion
Adjuvant chemotherapy after surgical resection in patients with SCLC improved the OS, though adjuvant radiotherapy to the mediastinum did not improve the survival or decrease the locoregional recurrence rate.

Citations

Citations to this article as recorded by  
  • Application of postoperative adjuvant radiotherapy in limited-stage small cell lung cancer: A systematic review and meta-analysis
    Chuanhao Zhang, Genghao Zhao, Huajian Wu, Jianing Jiang, Wenyue Duan, Zhijun Fan, Zhe Wang, Ruoyu Wang
    Radiotherapy and Oncology.2024; 193: 110123.     CrossRef
  • A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection
    Sevcan Atay
    Cancers.2023; 15(21): 5219.     CrossRef
  • 5,802 View
  • 142 Download
  • 2 Web of Science
  • 2 Crossref
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Gastrointestinal Cancer
Pulmonary Metastasectomy in Colorectal Cancer: A Population-Based Retrospective Cohort Study Using the Korean National Health Insurance Database
Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
Cancer Res Treat. 2021;53(4):1104-1112.   Published online January 15, 2021
DOI: https://doi.org/10.4143/crt.2020.1213
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The study aimed to investigate the current status and prognostic factors for overall survival in patients who had undergone pulmonary metastasectomy for colorectal cancer.
Materials and Methods
The data of 2,573 patients who had undergone pulmonary metastasectomy after surgery for colorectal cancer between January 2009 and December 2014 were extracted from the Korean National Health Insurance Service claims database. Patient-, colorectal cancer–, pulmonary metastasis–, and hospital-related factors were analyzed using the Kaplan-Meier method, log-rank test, and Cox proportional hazards analysis to identify prognostic factors for overall survival after pulmonary metastasectomy.
Results
The mean age of the patients was 60.9±10.5 years; 66.2% and 79.1% of the participants were male and had distally located colorectal cancer, respectively. Wedge resection (71.7%) was the most frequent extent of pulmonary resection; 21.8% of the patients underwent repeated pulmonary metastasectomies; 73% of pulmonary metastasectomy cases were performed in tertiary hospitals; 53.9% of patients were treated in Seoul area; 82% of patients received chemotherapy in conjunction with pulmonary metastasectomy. The median survival duration was 51.8 months. The 3- and 5-year overall survival rates were 67.7% and 39.4%, respectively. In multivariate analysis, female sex, distally located colorectal cancer, pulmonary metastasectomy-only treatment, and high hospital volume (> 10 pulmonary metastasectomy cases/yr) were positive prognostic factors for survival.
Conclusion
Pulmonary metastasectomy seemed to provide long-term survival of patients with colorectal cancer. The female sex, presence of distally located colorectal cancer, and performance of pulmonary metastasectomy in high-volume centers were positive prognostic factors for survival.

Citations

Citations to this article as recorded by  
  • Lungenmetastasen extrathorakaler Tumoren
    Matthias Grott, Hauke Winter, Martin Eichhorn
    Pneumo News.2024; 16(1): 36.     CrossRef
  • The Clinical Efficacy of Colorectal Cancer Patients with Pulmonary Oligometastases by Sterotactic Body Ablative Radiotherapy: A Meta-Analysis
    Jae-Uk Jeong, Chai Hong Rim, Gyu Sang Yoo, Won Kyung Cho, Eui Kyu Chie, Yong Chan Ahn, Jong Hoon Lee
    Cancer Research and Treatment.2024; 56(3): 809.     CrossRef
  • Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases
    Dima Hammoud, Matthieu Glorion, Pietro Genova, Mostapha El Hajjam, Jalal Assouad, Frédérique Peschaud, Cindy Neuzillet, Denis Debrosse, Renato Micelli Lupinacci
    Journal of Gastrointestinal Cancer.2023; 54(4): 1185.     CrossRef
  • Survival of Patients With Metastatic Rectum Cancer Who Underwent Metastasectomy Following Conversion Chemotherapy Sans Pelvic Radiotherapy: A Turkish Oncology Group Study
    Elvina Almuradova, Suayib Yalcin, Rukiye Arıkan, Murat Ayhan, Hacer Demir, Gokcen Tugba Cevik, Mustafa Karaca, Ibrahim Petekkaya, Bulent Karabulut
    Cureus.2023;[Epub]     CrossRef
  • Laparoscopic Resection of Synchronous Liver Metastasis Involving the Left Hepatic Vein and the Common Trunk Bifurcation: A Strategy of Parenchyma-Sparing Resection with Left Sectionectomy and 4a Subsegmentectomy by Arantius Approach
    Filippo Banchini, Enrico Luzietti, Gerardo Palmieri, Deborah Bonfili, Andrea Romboli, Luigi Conti, Patrizio Capelli
    Healthcare.2022; 10(3): 517.     CrossRef
  • Prognostic Factors in Stage IV Colorectal Cancer Patients With Resection of Liver and/or Pulmonary Metastases: A Population-Based Cohort Study
    Panxin Peng, Yusong Luan, Peng Sun, Liming Wang, Xufeng Zeng, Yangyang Wang, Xuhao Cai, Peide Ren, Yonggang Yu, Qi Liu, Haoyue Ma, Huijing Chang, Bolun Song, Xiaohua Fan, Yinggang Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Determining Which Patients Require Preoperative Pelvic Radiotherapy Before Curative-Intent Surgery and/or Ablation for Metastatic Rectal Cancer
    Jeong Il Yu, Gyu Sang Yoo, Hee Chul Park, Doo Ho Choi, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin, Joon Oh Park, Seung Tae Kim, Young Suk Park, Jeeyun Lee, Won Ki Kang, Ho Yeong Lim, Jung Yong
    Annals of Surgical Oncology.2022; 29(7): 4197.     CrossRef
  • Patterns and predictors of recurrence after laparoscopic resection of rectal cancer
    Hong Yang, Lei Chen, Xiuxiu Wu, Chenghai Zhang, Zhendan Yao, Jiadi Xing, Ming Cui, Beihai Jiang, Xiangqian Su
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Radiomics complements clinical, radiological, and technical features to assess local control of colorectal cancer lung metastases treated with radiofrequency ablation
    Romane Markich, Jean Palussière, Vittorio Catena, Maxime Cazayus, Marianne Fonck, Dominique Bechade, Xavier Buy, Amandine Crombé
    European Radiology.2021; 31(11): 8302.     CrossRef
  • The Pulmonary Metastasectomy in Colorectal Cancer cohort study: Analysis of case selection, risk factors and survival in a prospective observational study of 512 patients
    Tom Treasure, Vernon Farewell, Fergus Macbeth, Tim Batchelor, Mišel Milošević, Juliet King, Yan Zheng, Pauline Leonard, Norman R. Williams, Chris Brew‐Graves, Lesley Fallowfield
    Colorectal Disease.2021; 23(7): 1793.     CrossRef
  • 6,326 View
  • 148 Download
  • 10 Web of Science
  • 10 Crossref
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Current Trends of Lung Cancer Surgery and Demographic and Social Factors Related to Changes in the Trends of Lung Cancer Surgery: An Analysis of the National Database from 2010 to 2014
Samina Park, In Kyu Park, Eung Re Kim, Yoohwa Hwang, Hyun Joo Lee, Chang Hyun Kang, Young Tae Kim
Cancer Res Treat. 2017;49(2):330-337.   Published online July 18, 2016
DOI: https://doi.org/10.4143/crt.2016.196
AbstractAbstract PDFPubReaderePub
Purpose
We investigated current trends in lung cancer surgery and identified demographic and social factors related to changes in these trends.
Materials and Methods
We estimated the incidence of lung cancer surgery using a procedure code-based approach provided by the Health Insurance Review and Assessment Service (http://opendata.hira.or.kr). The population data were obtained every year from 2010 to 2014 from the Korean Statistical Information Service (http://kosis.kr/). The annual percent change (APC) and statistical significance were calculated using the Joinpoint software.
Results
From January 2010 to December 2014, 25,687 patients underwent 25,921 lung cancer surgeries, which increased by 45.1% from 2010 to 2014. The crude incidence rate of lung cancer surgery in each year increased significantly (APC, 9.5; p < 0.05). The male-to-female ratio decreased from 2.1 to 1.6 (APC, −6.3; p < 0.05). The incidence increased in the age group of ≥ 70 years for both sexes (male: APC, 3.7; p < 0.05; female: APC, 5.96; p < 0.05). Furthermore, the proportion of female patients aged ≥ 65 years increased (APC, 7.2; p < 0.05), while that of male patients aged < 65 years decreased (APC, −3.9; p < 0.05). The proportions of segmentectomies (APC, 17.8; p < 0.05) and lobectomies (APC, 7.5; p < 0.05) increased, while the proportion of pneumonectomies decreased (APC, −6.3; p < 0.05). Finally, the proportion of patients undergoing surgery in Seoul increased (APC, 1.1; p < 0.05), while the proportion in other areas decreased (APC, −1.5; p < 0.05).
Conclusion
An increase in the use of lung cancer surgery in elderly patients and female patients, and a decrease in the proportion of patients requiring extensive pulmonary resection were identified. Furthermore, centralization of lung cancer surgery was noted.

Citations

Citations to this article as recorded by  
  • Clinical characteristics and course of pulmonary artery stump thrombosis following lung cancer surgery: A retrospective study from tertiary care hospital
    Ji-Eun Park, Seung-Ick Cha, Deok Heon Lee, Eung Bae Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Seung-Soo Yoo, Shin-Yup Lee, Jaehee Lee, Chang-Ho Kim, Jae-Yong Park
    Medicine.2024; 103(2): e36879.     CrossRef
  • Lung cancer screening, diagnosis, and treatment: The radiologist's perspective
    Bingqing Long, Zeng Xiong, Manzo Habou
    Meta-Radiology.2024; 2(1): 100066.     CrossRef
  • Inter-prefectural and urban–rural regional disparities in lung cancer surgery: a Japanese nationwide population-based cohort study from 2017 to 2019
    Masamitsu Kido, Satoru Okada, Naoyuki Takashima, Luying Yan, Atsuki Uchibori, Koji Sensaki, Tetsuo Kido, Masayoshi Inoue
    Surgery Today.2024; 54(12): 1428.     CrossRef
  • Peri- and postoperative morbidity and mortality in older patients with non-small cell lung cancer: a matched-pair study
    Seyer Safi, Maximilian Robert Gysan, Dorothea Weber, Rouven Behnisch, Thomas Muley, Michael Allgäuer, Hauke Winter, Hans Hoffmann, Martin Eichhorn
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study
    So Yeon Kim, Gerard A. Silvestri, Yeon Wook Kim, Roger Y. Kim, Sang-Won Um, Yunjoo Im, Jung Hye Hwang, Seung Ho Choi, Jung Seop Eom, Kang Mo Gu, Yong-Soo Kwon, Shin Yup Lee, Hyun Woo Lee, Dong Won Park, Yeonjeong Heo, Seung Hun Jang, Kwang Yong Choi, Yeol
    Journal of Thoracic Oncology.2024;[Epub]     CrossRef
  • Advanced surgical technologies for lung cancer treatment: Current status and perspectives
    Hongfei Cai, Yonghui Wang, Da Qin, Youbin Cui, Hongbo Zhang
    Engineered Regeneration.2023; 4(1): 55.     CrossRef
  • Domestic medical travel from non-Seoul regions to Seoul for initial breast cancer treatment: a nationwide cohort study
    Jae Ho Jeong, Jinhong Jung, Hee Jeong Kim, Jong Won Lee, Beom-Seok Ko, Byung Ho Son, Kyung Hae Jung, Il Yong Chung
    Annals of Surgical Treatment and Research.2023; 104(2): 71.     CrossRef
  • Crataegus pinnatifida Bunge root extract induces apoptosis of murine lung carcinoma cells in vitro
    Minjeong Kwon, Jongbeom Chae, Ju-Ock Nam
    Journal of Applied Biological Chemistry.2023;[Epub]     CrossRef
  • Disparities in lung cancer short- and long-term outcomes after surgery: Analysis from the national cancer database
    Mark R. Korst, Aman M. Patel, Daniel J. Garcia, Akash R. Patel, Hassaam S. Choudhry, Joseph G. Santitoro, Vincent Yeung, Joshua A. Kra
    Cancer Treatment and Research Communications.2023; 37: 100777.     CrossRef
  • Trend of lung cancer surgery, hospital selection, and survival between 2005 and 2016 in South Korea
    Dohun Kim, Gil‐Won Kang, Hoyeon Jang, Jun Yeun Cho, Bumhee Yang, Hee Chul Yang, Jinwook Hwang
    Thoracic Cancer.2022; 13(2): 210.     CrossRef
  • Current Status of Lung Cancer and Surgery Based on Studies Using a Nationwide Database
    Dohun Kim, Jung-Won Lee
    Journal of Chest Surgery.2022; 55(1): 1.     CrossRef
  • Assessment of textbook outcome after lobectomy for early‐stage non‐small cell lung cancer in a Korean institution: A retrospective study
    Woo Sik Yu, Jaeyong Shin, Jung A Son, Joonho Jung, Seokjin Haam
    Thoracic Cancer.2022; 13(8): 1211.     CrossRef
  • Pulmonary vein stump thrombosis after lung resection for lung cancer: clinical features and outcome
    Ji-Eun Park, Seung-Ick Cha, Deok Heon Lee, Eung Bae Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Seung-Soo Yoo, Shin-Yup Lee, Jaehee Lee, Chang-Ho Kim, Jae-Yong Park
    Blood Coagulation & Fibrinolysis.2022; 33(6): 295.     CrossRef
  • Healthcare vulnerability disparities in pancreatic cancer treatment and mortality using the Korean National Sample Cohort: a retrospective cohort study
    Sung Hoon Jeong, Hyeon Ji Lee, Choa Yun, Il Yun, Yun Hwa Jung, Soo Young Kim, Hee Seung Lee, Sung-In Jang
    BMC Cancer.2022;[Epub]     CrossRef
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    Aakash M. Shah, Emaad Siddiqui, Sari D. Holmes, Alexis Okoh, Mohamed Abdullah, Kristopher Deatrick, Sunjay Kaushal, Justin Sambol
    The Journal of Thoracic and Cardiovascular Surgery.2021; 161(3): 1064.     CrossRef
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    Kyu-Tae Han, Woorim Kim, Seungju Kim
    International Journal of Environmental Research and Public Health.2021; 18(7): 3462.     CrossRef
  • Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?
    Elizabeth Ahern, Ben J Solomon, Rina Hui, Nick Pavlakis, Ken O'Byrne, Brett G M Hughes
    Journal for ImmunoTherapy of Cancer.2021; 9(6): e002248.     CrossRef
  • Do Patients Residing in Provincial Areas Transport and Spend More on Cancer Treatment in Korea?
    Woorim Kim, Kyu-Tae Han, Seungju Kim
    International Journal of Environmental Research and Public Health.2021; 18(17): 9247.     CrossRef
  • Pulmonary Metastasectomy in Colorectal Cancer: A Population-Based Retrospective Cohort Study Using the Korean National Health Insurance Database
    Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
    Cancer Research and Treatment.2021; 53(4): 1104.     CrossRef
  • Rare location and drainage pattern of right pulmonary veins and aberrant right upper lobe bronchial branch: A case report
    Fu-Qiang Wang, Rui Zhang, Han-Lu Zhang, Yun-Hai Mo, Yu Zheng, Guang-Hao Qiu, Yun Wang
    World Journal of Clinical Cases.2021; 9(32): 9954.     CrossRef
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    Rob Stirling, Michael Stenger, John Zalcberg
    Lung Cancer.2020; 142: 138.     CrossRef
  • Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis
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    BMC Surgery.2020;[Epub]     CrossRef
  • Time trends and predictors of survival in surgically resected early‐stage non–small cell lung cancer patients
    Jitesh B. Shewale, Erin M. Corsini, Arlene M. Correa, Eric L. Brown, Luis G. Leon‐Novelo, Alan G. Nyitray, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack Roth, Garrett L. Walsh, Ara A. Vaporciyan, Stephen G. Swisher, Boris Sepe
    Journal of Surgical Oncology.2020; 122(3): 495.     CrossRef
  • Patterns of percutaneous transthoracic needle biopsy (PTNB) of the lung and risk of PTNB-related severe pneumothorax: A nationwide population-based study
    Bo Ram Yang, Mi-Sook Kim, Chang Min Park, Soon Ho Yoon, Kum Ju Chae, Joongyub Lee, James West
    PLOS ONE.2020; 15(7): e0235599.     CrossRef
  • Surgical Treatment of Lung Cancer
    Haley Hoy, Thuy Lynch, Monica Beck
    Critical Care Nursing Clinics of North America.2019; 31(3): 303.     CrossRef
  • Higher Age Puts Lung Cancer Patients at Risk for Not Receiving Anti-cancer Treatment
    Won-Il Choi, Jiah Choi, Mi-Ae Kim, Gyumin Lee, Jihyeon Jeong, Choong Won Lee
    Cancer Research and Treatment.2019; 51(3): 1241.     CrossRef
  • Recent Trends in Demographics, Surgery, and Prognosis of Patients with Surgically Resected Lung Cancer in a Single Institution from Korea
    Jae Kwang Yun, Han Pil Lee, Geun Dong Lee, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Sehoon Choi
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Pharmacodynamics of Pre-Operative PD1 checkpoint blockade and receptor activator of NFkB ligand (RANKL) inhibition in non-small cell lung cancer (NSCLC): study protocol for a multicentre, open-label, phase 1B/2, translational trial (POPCORN)
    Elizabeth Ahern, Annette Cubitt, Emma Ballard, Michele W. L. Teng, William C. Dougall, Mark J. Smyth, David Godbolt, Rishendran Naidoo, Amanda Goldrick, Brett G. M. Hughes
    Trials.2019;[Epub]     CrossRef
  • Progress in the Management of Early-Stage Non–Small Cell Lung Cancer in 2017
    Jessica S. Donington, Young Tae Kim, Betty Tong, Andre L. Moreira, Jamie Bessich, Kathleen D. Weiss, Yolonda L. Colson, Dennis Wigle, Raymond U. Osarogiagbon, Jeffrey Zweig, Heather Wakelee, Justin Blasberg, Megan Daly, Leah Backhus, Paul Van Schil
    Journal of Thoracic Oncology.2018; 13(6): 767.     CrossRef
  • 10,741 View
  • 290 Download
  • 16 Web of Science
  • 29 Crossref
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Inquiry about Management of Non-Small Cell Lung Cancer
Jae Young Park, Jung Suk Kim, Sin Kam, Sang Chul Chae, Jun Hee Won, Chang Ho Kim, Jae Chul Kim, Sang Hoon Jun, In Kyu Park, Tae Hoon Jung
J Korean Cancer Assoc. 1998;30(2):214-224.
AbstractAbstract PDF
PURPOSE
In recent years there has been a considerable increase in the use of chemotherapy as an adjuvant to surgery, radical radiotherapy and in addition to best supportive care. However, the value of chemotherapy in improving survival is still unclear, despite more than 50 randomised trials addressing this question in the different stages of disease. This study was done to evaluate Korean doctors' personal management preference and their beliefs about prognosis in non-small celllung cancer(NSCLC).
MATERIALS AND METHODS
A mail survey of Korean respirologists, thoracic surgeons, radiation oncologists, and medical oncologists was performed. Four cases of NSCLC were described and respondents were asked to give their treatment recommendations and to estimate the prognosis in each case.
RESULTS
After a complete resection for stage II NSCLC, 27% recommended no adjuvant treatment, 36% recommended radiotherapy, 18% recommended chemotherapy, and 19% recommended both radiotherapy and chemotherapy. After a complete resection for stage IIIA(N2) NSCLC, the vast majority of respondents recommended adjuvant therapy. For an asymptomatic patient with stage IIIB NSCLC, 5% recommended supportive care, 24% recommended radiotherapy, 16% recommended chemotherapy, and 54% recommended chemotherapy combined with radiotherapy. For a patient with stage IV NSCLC, 76% recommended chemotherapy with or without palliative radiotherapy. Doctors' treatment preference was significantly different by their speciliaty in a case with stage II, IIIA(N2), or IV NSCLC. Most respondents believed that chemotherapy would increase survival in NSCLC. Doctors' beliefs about the efficacy of treatment were strongly associated with their treatment recommendations.
CONCLUSION
Korean doctors generally preferred relatively aggressive management although their personal preferences varied widely. Team approach is important in deciding the treatment modality because doctors' treatment preference is different by their speciality.
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A Case of Primary Malignant Lymhoma of the CNA
Cjul Sung Kwak, Jung Lim Lee, Dong Wook Kim, Sang Il Cheon, Sang Cheul Kim, Sae Kwang Moon, In Kyu Park
J Korean Cancer Assoc. 1987;19(2):119-125.
AbstractAbstract PDF
Primary CNS lym poma is a multifocal, infiltrative, malignant lymphoma that has a predilection for paraventricular areas. This tumor occurs with increased frequency in patients who are immunologically suppressed, particulary those with organ transplants or AIDS. Radiotherapy has traditionally been administered to patients with CNS lymphomas. But the failure in the brain at sites of other than those originally involved was common in spite of the use of whole brain irradiation. We experienced a case of a patient with primary CNS malignant lymphoma who had multicentric recurrence in spinal axis following whole brain radiotherapy. So we have reported the case with the review of previous literatures.
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