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Head and Neck cancer
Long-term Survivorship and Non-cancer Competing Mortality in Head and Neck Cancer: A Nationwide Population-Based Study in South Korea
Yuh-Seog Jung, Dahhay Lee, Kyu-Won Jung, Hyunsoon Cho
Cancer Res Treat. 2023;55(1):50-60.   Published online March 4, 2022
DOI: https://doi.org/10.4143/crt.2021.1086
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
As the survival of head and neck cancer (HNC) improves, survivors increasingly confront non-cancer–related deaths. This nationwide population-based study aimed to investigate non-cancer–related deaths in HNC survivors.
Materials and Methods
Data from the Korean Central Cancer Registry were obtained to characterize causes of death, mortality patterns, and survival in patients with HNC between 2006 and 2016 (n=40,890). Non-cancer-related mortality relative to the general population was evaluated using standardized mortality ratios (SMRs). The 5- and 10-year cause-specific competing risks probabilities of death (cumulative incidence function, CIF) and subdistribution hazards ratios (sHR) from the Fine-Gray models were estimated.
Results
Comorbidity-related mortality was frequent in older patients, whereas suicide was predominant in younger patients. The risk of suicide was greater in patients with HNC than in the general population (SMR, 3.1; 95% confidence interval [CI], 2.7 to 3.5). The probability of HNC deaths reached a plateau at 5 years (5-year CIF, 33.9%; 10-year CIF, 39.5%), whereas the probability of non-HNC deaths showed a long-term linear increase (5-year, CIF 5.6%; 10-year CIF, 11.9%). Patients who were male (sHR, 1.56; 95% CI, 1.41 to 1.72), diagnosed with early-stage HNC (localized vs. distant: sHR, 1.86; 95% CI, 1.58 to 2.21) and older age (65-74 vs. 0-44: sHR, 6.20; 95% CI, 4.92 to 7.82; ≥ 75 vs. 0-44: sHR, 9.81; 95% CI, 7.76 to 12.39) had an increased risk of non-cancer mortality.
Conclusion
Non-HNC–related deaths continue increasing. HNC survivors are at increased risk of suicide in the younger and comorbidity-related death in the older. Better population-specific surveillance awareness and survivorship plans for HNC survivors are warranted.

Citations

Citations to this article as recorded by  
  • Surviving and thriving: Assessing quality of life and psychosocial interventions in mental health of head and neck cancer patients
    Liqing Lin, Hao Lin, Renbin Zhou, Bing Liu, Kaige Liu, Ronghua Jiang
    Asian Journal of Surgery.2025; 48(3): 1634.     CrossRef
  • Time‐varying association of second primary malignancy and long‐term survival outcomes in patients with head and neck cancer
    Xiaoke Zhu, Yu Heng, Jian Zhou, Hanqing Lin, Liang Zhou, Ming Zhang, Pengyu Cao, Lei Tao
    International Journal of Cancer.2023; 153(1): 94.     CrossRef
  • 5,406 View
  • 160 Download
  • 4 Web of Science
  • 2 Crossref
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Breast cancer
Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors
Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Na Yeon Kim, Sungkeun Shim, Ho Young Kim, Danbee Kang, Juhee Cho, Eunsook Lee, Yoon Jung Chang, Hyunsoon Cho
Cancer Res Treat. 2022;54(4):1065-1073.   Published online December 8, 2021
DOI: https://doi.org/10.4143/crt.2021.835
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Fear of cancer recurrence (FCR) is a common psychological issue in breast cancer (BC) survivors during early survivorship but whether the same is true among long-term survivors has yet to be empirically evaluated. This study investigated FCR level, its associated factors, and impact on quality of life (QoL) in long-term BC survivors.
Materials and Methods
Participants included women diagnosed with BC between 2004 and 2010 at two tertiary hospitals. Survey was conducted in 2020. The study measured FCR with the Fear of Cancer Recurrence Inventory and other patient-reported outcomes, including depression and cancer-related QoL. Logistic regression was used to identify factors associated with FCR, and structural equation modeling was conducted to explore the impact of FCR on other outcomes.
Results
Of 333 participants, the mean age at diagnosis was 45.5, and 46% experienced FCR. Age at diagnosis ≤ 45 (adjusted odds ratio [aOR], 2.64; 95% confidence interval [CI], 1.51 to 4.60), shorter time since diagnosis (aOR, 1.75, 95% CI, 1.08 to 2.89), and having a history of recurrence (aOR, 2.56; 95% CI, 1.16 to 5.65) was associated with more FCR. FCR was significantly associated with an increased risk of depression (β=0.471, p < 0.001) and negatively impacted emotional functioning (β=–0.531, p < 0.001). In addition, a higher FCR level may impair overall health-related QoL in long-term BC survivors (β=–0.108, p=0.021).
Conclusion
Ten years after diagnosis, long-term BC survivors still experienced a high level of FCR. Further, the negative impact of FCR on QoL and increased depression risk require an FCR screening and appropriate interventions to enhance long-term BC survivors' QoL.

Citations

Citations to this article as recorded by  
  • Health-related quality of life in long-term early-stage breast cancer survivors compared to general population in Korea
    Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Na Yeon Kim, Sungkeun Shim, Ho Young Kim, Danbee Kang, Juhee Cho, Eunsook Lee, Yoonjung Chang, Hyunsoon Cho
    Journal of Cancer Survivorship.2025; 19(2): 487.     CrossRef
  • CANCER. Is this Forever? Examining the Relationship Between Event Centrality and Fear of Cancer Recurrence from a Cognitive-Behavioral Standpoint
    Diana Todea, Andreea Luca, Ioana R. Podina
    Journal of Rational-Emotive & Cognitive-Behavior Therapy.2025;[Epub]     CrossRef
  • Fear of the Cancer Coming Back: A Metasynthesis of Fear of Recurrence in Breast Cancer
    Kai‐Yue Wang, Hui Li, Nan Qin
    Public Health Nursing.2025; 42(1): 457.     CrossRef
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    Yingting Jiang, Xinyu Wu, Hongman Li, Ying Xiong, M. Tish Knobf, Zengjie Ye
    European Journal of Oncology Nursing.2025; 74: 102799.     CrossRef
  • Dyadic effects of illness perception and maladaptive cognitive-emotional regulation strategies on the fear of cancer recurrence in breast cancer patients and spouses: an actor-partner interdependence mediation model
    Hui Ren, Tianye Yang, Songli Mei, Zhu Zhu, Jianjun Shi, Lingling Tong, Jia Yang, Yabin Sun
    BMC Psychiatry.2025;[Epub]     CrossRef
  • Validating the Black Identity, Hair Product Use, and Breast Cancer Scale (BHBS) Among Black Breast Cancer Survivors
    Dede K. Teteh-Brooks, Marissa Ericson, Traci N. Bethea, Lenna Dawkins-Moultin, Nicole Sarkaria, Jared Bailey, Adana A. M. Llanos, Susanne Montgomery
    International Journal of Environmental Research and Public Health.2025; 22(2): 174.     CrossRef
  • The Lived Experience of Suffering by Nigerian Female Breast Cancer Survivors: A Phenomenological Perspective
    Chinomso Ugochukwu Nwozichi, Margaret Olutosin Ojewale, Omolabake Salako, Deliverance Brotobor, Elizabeth Olaogun
    Journal of Patient Experience.2025;[Epub]     CrossRef
  • Examining the Sequential Relationships Between Voice Changes, Symptom Experiences, Fear of Cancer Recurrence, and Voice-Related Quality of Life in Patients With Thyroid Cancer
    Myung Kyung Lee, Jihyun Oh
    Cancer Nursing.2025;[Epub]     CrossRef
  • Cancer Recurrence Fear and Return to Work in Breast Cancer Survivors:The Mediating Effects of Health Literacy
    Xiaoli Zhu, Juanjuan Lei, Rong Chen, Zhu Chen, Zhengchong Xiong, Lin Yang, Mengxiao Jiang, Huiting Zhang
    Journal of Multidisciplinary Healthcare.2025; Volume 18: 1031.     CrossRef
  • Satisfaction with and perceived benefits of needs-assessment related to rehabilitation after chemotherapy among patients with breast cancer
    Marta Kramer Mikkelsen, Helle Elisabeth Jensen, Guri Spiegelhauer, Kirsten Amdi, Kasper Madsen, Kirstine Steen Nybom, Rikke Balschmidt Holm-Petersen, Dorte Nielsen
    Disability and Rehabilitation.2024; 46(12): 2548.     CrossRef
  • Fear of recurrence in postoperative lung cancer patients: Trajectories, influencing factors and impacts on quality of life
    Xiaoyan Yang, Yonglin Li, Jialing Lin, Jianqing Zheng, Huimin Xiao, Weiti Chen, Feifei Huang
    Journal of Clinical Nursing.2024; 33(4): 1409.     CrossRef
  • Unmet care needs of women who have undergone breast cancer surgery: A scoping review
    Qiaohong Ke, Fiona Timmins, Eileen Furlong, Diarmuid Stokes
    Journal of Advanced Nursing.2024; 80(5): 1732.     CrossRef
  • Dyadic association between mindfulness, family avoidance of communication about cancer and fear of cancer recurrence among breast cancer couples: A cross-sectional study
    Xiangyu Zhao, Yunxue Zhang, Rui Qin, Guopeng Li, Xudong He, Xiaona Shen, Ping Li
    European Journal of Oncology Nursing.2024; 68: 102491.     CrossRef
  • Prevalence and Factors Contributing to Fear of Recurrence in Breast Cancer Patients and Their Partners: A Cross-Sectional Study
    Ling Tong, Yuan Wang, Dewu Xu, Yibo Wu, Ling Chen
    International Journal of Women's Health.2024; Volume 16: 229.     CrossRef
  • Fear of Cancer Progression: A Comparison between the Fear of Progression Questionnaire (FoP-Q-12) and the Concerns about Recurrence Questionnaire (CARQ-4)
    Andreas Hinz, Thomas Schulte, Anja Mehnert-Theuerkauf, Diana Richter, Annekathrin Sender, Hannah Brock, Michael Friedrich, Susanne Briest
    Healthcare.2024; 12(4): 435.     CrossRef
  • Factors affecting the fear of recurrence in Breast cancer patients
    Dinara Kussainova, Anar Tursynbekova, Gulshara Aimbetova, Fatima Bagiyarova, Dilyara Kaidarova
    Research Journal of Pharmacy and Technology.2024; : 314.     CrossRef
  • Fear of Cancer Recurrence in Differentiated Thyroid Cancer Survivors: A Systematic Review
    Jacob Hampton, Ahmad Alam, Nicholas Zdenkowski, Christopher Rowe, Elizabeth Fradgley, Christine J. O'Neill
    Thyroid®.2024; 34(5): 541.     CrossRef
  • Revisiting Combined Modality Therapy in Older Patients With Luminal Breast Cancer Through the Patient Lens
    Robert W. Mutter, Cynthia Chauhan, Matthew P. Goetz, Jean L. Wright
    Journal of Clinical Oncology.2024; 42(18): 2121.     CrossRef
  • The impact of fear of cancer recurrence on the quality of life of breast cancer patients: A longitudinal study of the mediation effect of cortisol and hope
    Meidi Xiong, Yuping Cheng, Ying Luo, Chao Fang, Hongmei Yao, Qianqian Liu, Fang Lu, Xuan Li, Ziying Bie, Jinbing Bai, Chunhua Zhang
    European Journal of Oncology Nursing.2024; 70: 102600.     CrossRef
  • Psychosocial factors associated with quality of life in cancer survivors: umbrella review
    Viktorya Voskanyan, Chiara Marzorati, Diana Sala, Roberto Grasso, Ricardo Pietrobon, Iris van der Heide, Merel Engelaar, Nanne Bos, Augusto Caraceni, Norbert Couspel, Montse Ferrer, Mogens Groenvold, Stein Kaasa, Claudio Lombardo, Aude Sirven, Hugo Vachon
    Journal of Cancer Research and Clinical Oncology.2024;[Epub]     CrossRef
  • Enhancing Early-Stage Breast Cancer Survivorship: Evidence-Based Strategies, Surveillance Testing, and Imaging Guidelines
    Mitchell J. Elliott, Sherry Shen, Diana L. Lam, Thelma Brown, Marissa B. Lawson, Neil M. Iyengar, David W. Cescon
    American Society of Clinical Oncology Educational Book.2024;[Epub]     CrossRef
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    Hongyan Li, Yabin Sun, Tianye Yang, Xin Yin, Zhu Zhu, Jianjun Shi, Lingling Tong, Jia Yang, Hui Ren
    BMC Nursing.2024;[Epub]     CrossRef
  • Understanding Reasons for Cancer Disparities in Italy: A Qualitative Study of Barriers and Needs of Cancer Patients and Healthcare Providers
    Giulia Ferraris, Veronica Coppini, Maria Vittoria Ferrari, Dario Monzani, Roberto Grasso, Gabriella Pravettoni
    Cancer Control.2024;[Epub]     CrossRef
  • Latent profile analysis and related factors for fear of cancer recurrence among Chinese breast cancer patients in rehabilitation
    Yinjie Bai, Jing Zhang, Yujing Sun, Yingying Wang, Huangfei Xu
    European Journal of Oncology Nursing.2024; 71: 102651.     CrossRef
  • Infographics on signs and symptoms of metastatic (secondary) breast cancer can empower women with a breast cancer diagnosis
    Nazanin Derakshan, Joanne Taylor, Bethany Chapman
    Frontiers in Psychology.2024;[Epub]     CrossRef
  • Virtual body and emotions: A pilot study on the use of virtual reality for the management of unpleasant sensations after cancer
    Valeria Sebri, Ilaria Durosini, Milija Strika, Silvia Francesca Maria Pizzoli, Ketti Mazzocco, Gabriella Pravettoni
    Counselling and Psychotherapy Research.2024; 24(4): 1632.     CrossRef
  • Correlation between symptom experience and fear of cancer recurrence in postoperative breast cancer patients undergoing chemotherapy in China: A cross-sectional study
    Manxia Han, Huaying Chen, Jialing Li, Xuemei Zheng, Xue Zhang, Lin Tao, Xiaoxia Zhang, Xianqiong Feng, Tim Luckett
    PLOS ONE.2024; 19(9): e0308907.     CrossRef
  • Addressing the Arguments Against Omitting Radiotherapy After Breast-Conserving Surgery for Early Luminal Breast Cancers
    A. Maghous, I. Lalya, E. Marnouche, M. Hommadi, M. Belemlih, K. Andaloussi Saghir, M. Elmarjany, K. Hadadi, H. Sifat
    Indian Journal of Gynecologic Oncology.2024;[Epub]     CrossRef
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    Ka Ryeong Bae, So Hee Kim
    Asian Oncology Nursing.2024; 24(3): 125.     CrossRef
  • Facilitating and Inhibiting Factors in Deciding to Start Retreatment in Survivors of Breast Cancer Recurrence
    Mahsa Matbouei, Majid Samsami, Mohsen Soleimani
    International Journal of Cancer Management.2023;[Epub]     CrossRef
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    D. Azria, C. Bourgier, C. Lemanski
    Cancer/Radiothérapie.2023; 27(3): 181.     CrossRef
  • Effects of CALM intervention on neutrophil-to-lymphocyte ratio (NLR), fear of cancer recurrence and quality of life in patients with lung cancer
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    Supportive Care in Cancer.2023;[Epub]     CrossRef
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    Sharon Manne, Katie Devine, Shawna Hudson, Deborah Kashy, Denalee O’Malley, Lisa E. Paddock, Elisa V. Bandera, Adana A. M. Llanos, Angela Fong, Neetu Singh, Sara Frederick, Andrew M. Evens
    BMC Cancer.2023;[Epub]     CrossRef
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    Seul Ki Park, Yul Ha Min
    Frontiers in Psychology.2023;[Epub]     CrossRef
  • Altered regional homogeneity and homotopic connectivity in Chinese breast cancer survivors with fear of cancer recurrence: A resting-state fMRI study
    Li Peng, Xiaofei Hu, Chen Xu, Yuanyuan Xu, Han Lai, Ying Yang, Ju Liu, Yuan Xue, Min Li
    Journal of Psychosomatic Research.2023; 173: 111454.     CrossRef
  • Protective Factors against Fear of Cancer Recurrence in Breast Cancer Patients: A Latent Growth Model
    Gabriella Bentley, Osnat Zamir, Rawan Dahabre, Shlomit Perry, Evangelos C. Karademas, Paula Poikonen-Saksela, Ketti Mazzocco, Berta Sousa, Ruth Pat-Horenczyk
    Cancers.2023; 15(18): 4590.     CrossRef
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    Priya Iyer
    The Lancet Regional Health - Southeast Asia.2022; 4: 100061.     CrossRef
  • 7,865 View
  • 242 Download
  • 35 Web of Science
  • 37 Crossref
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Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea
Tran Thi Xuan Mai, Jin Hyuk Choi, Myung Kyung Lee, Yoon Jung Chang, So-Youn Jung, Hyunsoon Cho, Eun Sook Lee
Cancer Res Treat. 2019;51(4):1600-1611.   Published online April 12, 2019
DOI: https://doi.org/10.4143/crt.2018.426
AbstractAbstract PDFPubReaderePub
Purpose
We aimed to evaluate health-related quality of life (HRQOL) at 1-year post-diagnosis in breast cancer (BC) patients and its association with overall survival using data from the National Cancer Center Hospital.
Materials and Methods
Data of a BC cohort were first obtained between 2004 and 2006 and followed up. HRQOL was assessed using EORTC QLQ-C30 and BC specific module QLQ-BR23 few days after diagnosis and 1 year after that. We examined and compared the difference in the two HRQOL scores measured for each patient by the patient’s current survival status. The Cox proportional hazards model was fitted to evaluate the impact of HRQOL on survival, with adjustment for baseline HRQOL and other factors.
Results
Of 299 enrolled patients, 206 responded at 1-year post-diagnosis (80.6%) and were followed up for 11.6 years on average. At 1-year post-diagnosis, survivors had better HRQOL scores than those who died, although their health status was similar at baseline. Survivors reported significant increase 1 year after diagnosis in global health status and emotional scales. Between the groups, functional scales such as physical, role, and emotional were significantly different. Functional scales, including physical (adjusted hazard ratio [aHR], 0.70), role (aHR, 0.68), emotional (aHR, 0.72), and symptom scales, including fatigue (aHR, 1.34), dyspnea (aHR, 1.29), appetite loss (aHR, 1.24) were significantly associated with overall survival. Patients who were less worried about future health had favorable survival (aHR, 0.83).
Conclusion
Besides treatment-related symptoms, non-medical aspects at 1-year post-diagnosis, including functional well-being and future perspective, are predictive of long-term survival. Intervention to enhance physical, role, and emotional support for women soon after their BC diagnosis might help to improve disease survival outcomes afterwards.

Citations

Citations to this article as recorded by  
  • Health-related quality of life in long-term early-stage breast cancer survivors compared to general population in Korea
    Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Na Yeon Kim, Sungkeun Shim, Ho Young Kim, Danbee Kang, Juhee Cho, Eunsook Lee, Yoonjung Chang, Hyunsoon Cho
    Journal of Cancer Survivorship.2025; 19(2): 487.     CrossRef
  • Lower Adherence to Lifestyle Recommendations of the World Cancer Research Fund/American Institute for Cancer Research (2018) Is Associated with Decreased Overall 10-Year Survival in Women with Breast Cancer
    Jaqueline Schroeder de Souza, Luiza Kuhnen Reitz, Cândice Laís Knöner Copetti, Yara Maria Franco Moreno, Francilene Gracieli Kunradi Vieira, Patricia Faria Di Pietro
    Nutrients.2025; 17(6): 1001.     CrossRef
  • Long-term trajectory of postoperative health-related quality of life in young breast cancer patients: a 15-year follow-up study
    Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Juhee Cho, Eunsook Lee, Yoon Jung Chang, Hyunsoon Cho
    Journal of Cancer Survivorship.2023; 17(5): 1416.     CrossRef
  • Associations between health-related fitness and quality of life in newly diagnosed breast cancer patients
    Kerry S. Courneya, Ki-Yong An, Fernanda Z. Arthuso, Gordon J. Bell, Andria R. Morielli, Jessica McNeil, Qinggang Wang, Spencer J. Allen, Stephanie M. Ntoukas, Margaret L. McNeely, Jeff K. Vallance, S. Nicole Culos-Reed, Karen Kopciuk, Lin Yang, Charles E.
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    EPMA Journal.2023; 14(3): 457.     CrossRef
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    Adán Rodríguez-Gonzalez, Alberto Carmona-Bayonas, Raquel Hernandez San Gil, Patricia Cruz-Castellanos, Mónica Antoñanzas-Basa, David Lorente-Estelles, María Jose Corral, Manuel González-Moya, Oscar Alfredo Castillo-Trujillo, Emilio Esteban, Paula Jiménez-
    Clinical and Translational Oncology.2023; 25(12): 3492.     CrossRef
  • Illness Perception and Quality of Life in Patients with Breast Cancer
    Edyta Ośmiałowska, Jakub Staś, Mariusz Chabowski, Beata Jankowska-Polańska
    Cancers.2022; 14(5): 1214.     CrossRef
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    Journal of Nursing Research.2022;[Epub]     CrossRef
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    Cancers.2022; 14(17): 4133.     CrossRef
  • Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors
    Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Na Yeon Kim, Sungkeun Shim, Ho Young Kim, Danbee Kang, Juhee Cho, Eunsook Lee, Yoon Jung Chang, Hyunsoon Cho
    Cancer Research and Treatment.2022; 54(4): 1065.     CrossRef
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  • 189 Download
  • 12 Web of Science
  • 15 Crossref
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Beliefs and Intentions to Undergo Lung Cancer Screening among Korean Males
Nhung Cam Bui, Yoon Young Lee, Mina Suh, Boyoung Park, Hyunsoon Cho, Yeol Kim, Kui Son Choi
Cancer Res Treat. 2018;50(4):1096-1105.   Published online November 16, 2017
DOI: https://doi.org/10.4143/crt.2017.393
AbstractAbstract PDFPubReaderePub
Purpose
Low-dose computed tomography (LDCT) has been reported as an effective screening method for lung cancer in high-risk populations. We aimed to examine willingness to be screened among Korean males using LDCT and to determine factors associated with lung cancer screening intentions (LCS) based on the Health Belief Model (HBM).
Materials and Methods
Data were obtained from the 2015 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling. The survey included 1,730 male participants 40-74-year-old. Respondents were questioned regarding their willingness to undergo LCS and components of HBM. Factors associated with intentions to undergo screening were explored using logistic regression.
Results
Among participants, 65.2% were current smokers. Among high-risk subjects, 60.6% of men reported intentions to undergo LCS, compared to 49.9% of average-risk males. Men with higher perceived susceptibility in the average- and high-risk groups were, respectively, 1.63 (95% confidence interval [CI], 1.39 to 1.91) and 2.30 (95% CI, 1.14 to 4.63) times more likely to intend to undergo LCS compared to those with lower perceived barriers. Also, men in the average- and high-risk groups with higher perceived barriers to screening were, respectively, 0.79 (95% CI, 0.68 to 0.91) and 0.52 (95% CI, 0.29 to 0.92) times less likely to intend to undergo LCS compared to those with lower perceived barriers.
Conclusion
Tailored interventions designed to promote accurate perceptions of susceptibility and risk, as well as to reduce perceived barriers to screening, may effectively increase adherence to recommendations for LCS among high-risk Korean men.

Citations

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Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea
Chang-Mo Oh, Hyunsoon Cho, Young-Joo Won, Hyun-Joo Kong, Yun Ho Roh, Ki-Heon Jeong, Kyu-Won Jung
Cancer Res Treat. 2018;50(3):729-737.   Published online July 14, 2017
DOI: https://doi.org/10.4143/crt.2017.166
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This descriptive study was aimed to examine trends in the incidence of melanoma and nonmelanoma in South Korea.
Materials and Methods
The nationwide incidence data for melanoma and non-melanoma skin cancer was obtained from the Korea Central Cancer Registry. Age-standardized rates were calculated and analyzed, using a Joinpoint regression model.
Results
The incidence of basal cell carcinoma has increased dramatically both in men (average annual percentage change [AAPC], 8.0 [95% confidence interval (CI), 6.0 to 10.1]) and women (AAPC, 9.0 [95% CI, 7.5 to 10.4]). Squamous cell carcinoma has also steadily increased both in men (AAPC, 3.3 [95% CI, 2.6 to 4.0]) and women (AAPC, 6.8 [95% CI, 5.3 to 8.4]). Cutaneous melanoma increased continuously from 1999 to 2014 inwomen (AAPC, 3.5 [95% CI, 2.4 to 4.6]), whilst rapidly increasing in men until 2005 (APC, 7.9 [95% CI, 2.4 to 13.7]) after which no increase has been observed (APC, ‒0.2 [95% CI, ‒2.3 to 2.0]).
Conclusion
The incidence rates of melanoma and non-melanoma skin cancer have increased over the past years, with the exception of melanoma in men. Further studies are required to investigate the reasons for the increased incidence of these skin cancers in South Korea.

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Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea
Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Hyunsoon Cho, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Cancer Res Treat. 2017;49(3):607-615.   Published online September 23, 2016
DOI: https://doi.org/10.4143/crt.2016.139
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This descriptive study assessed the current trends in the incidence of urological cancers and patient survival in Korea.
Materials and Methods
In this nationwide retrospective observational study based on the data from the Korea National Cancer Incidence Database (KNCIDB), this study analyzed the age-standardized incidence rates (ASRs) and annual percentage changes (APCs) of kidney, bladder, prostate, testicular, and penile cancers as well as cancer of the renal pelvis and ureter between 1999 and 2012. The relative survival rates (RSRs) were calculated for urological cancer patients diagnosed between 1993 and 2012 from the KNCIDB data.
Results
Prostate cancer was diagnosed in 66,812 individuals followed by bladder (41,549) and kidney (36,836) cancers. The overall ASR (18.26 per 100,000) increased with age because of the higher ASRs of bladder and prostate cancers in the elderly. The ASR for kidney cancer was highest in the 40-59-year-old group, whereas testicular cancer occurred most frequently before the age of 40. The incidence of most urological cancers increased (overall APC, 6.39%; p < 0.001), except for penile (APC, –2.01%; p=0.05) and bladder (APC, –0.40%; p=0.25) cancers. The overall survival increased steadily (5-year RSR, 66.4% in 1993-1995 vs. 84.2% in 2008-2012; p < 0.001), particularly for prostate (by 34.10%) and kidney (by 16.30%) cancers, but not for renal pelvis and ureter cancers (–7.20%).
Conclusion
The most common urological cancer in Korea was prostate cancer followed by bladder and kidney cancers. The incidence of most urological cancers, except for penile and bladder cancers, increased. Survival also increased, particularly for prostate and kidney cancers.

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Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
Cancer Res Treat. 2017;49(2):526-533.   Published online September 1, 2016
DOI: https://doi.org/10.4143/crt.2016.316
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to describe the trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea.
Materials and Methods
The incidence and mortality rate of cervical cancer among ≥ 20-year-old women from 1993 to 2012 were obtained from the Korea Central Cancer Registry and the Korean Statistical Information Service. Age-standardized rates were calculated and Joinpoint regression was used to evaluate the trends in the incidence and mortality rate. Age-period-cohort analysis was performed to investigate the independent effects of age, period and cohort.
Results
The incidence of cervical cancer decreased from 32.8 per 100,000 in 1993 to 15.9 per 100,000 in 2012 (annual percent change [APC], –3.9%; 95% confidence interval [CI], –4.2% to –3.6%). The mortality rate decreased from 5.2 per 100,000 in 1993 to 2.1 per 100,000 in 2012 (APC, –4.8%; 95% CI, –5.1% to –4.4%); however, the incidence and mortality rates among young women (< 30 years old) increased. An age-period-cohort model of the incidence and mortality rate showed decreasing period effects between 1993 and 2008 and decreasing cohort effects between 1928 and 1973, while birth cohorts after 1973 exhibited slight increases in the incidence and mortality rate of cervical cancer.
Conclusion
Recent decreases in the incidence and mortality rate of cervical cancer were due to decreases in the period and cohort effects, which reflect the implementation of a cancer screening program and changes in lifestyle. However, our findings also highlighted an increase in cohort effects on the incidence and mortality rate among young women born after 1973.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2016
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2016;48(2):451-457.   Published online March 25, 2016
DOI: https://doi.org/10.4143/crt.2016.092
AbstractAbstract PDFPubReaderePub
Purpose
To estimate of Korea’s current cancer burden, this study aimed to report on projected cancer incidence and mortality rates for the year 2016.
Materials and Methods
Cancer incidence data from 1999 to 2013 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2014 were acquired from Statistics Korea. Cancer incidence in 2016 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 254,962 new cancer cases and 75,172 cancer deaths are expected to occur in Korea in 2016. The five leading primary cancer incident sites in 2016 were estimated colorectal, stomach, lung, liver and thyroid cancer in men; thyroid, breast, colorectal, stomach, and lung cancer in women.
Conclusion
Currently cancer is one of the foremost public health concerns in Korea. Although cancer rates are anticipated to decrease the nation’s cancer burden will continue to increase as the population ages.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013
Chang-Mo Oh, Young-Joo Won, Kyu-Won Jung, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2016;48(2):436-450.   Published online March 3, 2016
DOI: https://doi.org/10.4143/crt.2016.089
AbstractAbstract PDFPubReaderePub
Purpose
This study described the 2013 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999-2013 were obtained from Korea National Cancer Incidence Database and followed until December 31, 2014. Mortality data from 1983-2013 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2014 among all cancer patients diagnosed since 1999. Crude, and age-standardized and 5-year relative survival rates were also calculated.
Results
In 2013, a total of 225,343 and 75,334 Koreans were newly diagnosed and died from cancer, respectively. The age-standardized rates for cancer incidence and mortality in 2013 were 290.5 and 87.9 per 100,000, respectively. The age-standardized cancer incidence rate increased 3.1% annually between 1999 and 2013. However, the overall cancer incidence rates have decreased slightly in recent years (2011 to 2013). The age-standardized rate for all-cancer mortality has decreased 2.7% annually since 2002. Overall, the 5-year relative survival rate for people diagnosed with cancer between 2009 and 2013 was 69.4%, which represents an improved survival rate as compared with 41.2% for people diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased between 2011 and 2013; mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2009-2013 in Korea.

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Prediction of Cancer Incidence and Mortality in Korea, 2015
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):142-148.   Published online March 17, 2015
DOI: https://doi.org/10.4143/crt.2015.066
AbstractAbstract PDFPubReaderePub
Purpose
For estimation of Korea’s current cancer burden, this study aimed to report on the projected cancer incidence and mortality rates for the year 2015. Materials and Methods Cancer incidence data from 1999 to 2012 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2013 were acquired from Statistics Korea. The cancer incidence in 2015 was projected by fitting a linear regression model to the observed age-specific cancer incidence rates against the observed years and then multiplying the projected age-specific rates by the age-specific population. A similar procedure was used for cancer mortality, except a Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 280,556 new cancer cases and 76,698 cancer deaths are expected to occur in Korea in 2015. The crude incidence rate per 100,000 of all sites combined will likely reach 551.6 and the age-standardized incidence rate, 347.6. The estimated five leading primary cancer incidence sites are the stomach, colorectum, lung, prostate, and liver in men; and thyroid, breast, colorectum, stomach, and lung in women. The projected crude mortality rate of all sites combined and age-standardized rate is 150.8 and 82.4, respectively. Conclusion Cancer is currently one of the foremost public health concerns in Korea, and as the population ages, the nation’s cancer burden will continue to increase.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):127-141.   Published online March 3, 2015
DOI: https://doi.org/10.4143/crt.2015.060
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study was to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends. Materials and Methods Incidence data from 1993 to 2012 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2013. Mortality data from 1983 to 2012 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated. Results A total of 224,177 cancer cases and 73,759 cancer deaths were reported in 2012, and there were 1,234,879 prevalent cases identified in Korea as of January 1, 2013. Over the past 14 years (1999-2012), overall incidence rates have increased by 3.3% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, incidence of thyroid cancer increased by 22.3% per year in both sexes and has been the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2012. Five-year relative survival rates of patients diagnosed in the last 5 years (2008-2012) have improved by 26.9% compared with those from 1993 to1995. Conclusion Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased and survival has improved.

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    Young Eun Seo, Hoyoung Ryu, Jong Jin Oh, Seong Jin Jeong, Sung Il Hwang, Hak Jong Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee, Sangchul Lee
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    Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Chungkil Won, Chang Keun Kang, Gon Sup Kim
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    Jae Ho Jeong, Sook Ryun Park, Yongchel Ahn, Min-Hee Ryu, Baek-Yeol Ryoo, Sun-Young Kong, Jeong Hwan Yook, Moon-Won Yoo, Beom Su Kim, Byung Sik Kim, Yoon-Koo Kang
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  • Unmet needs of non‐Hodgkin lymphoma survivors in Korea: prevalence, correlates, and associations with health‐related quality of life
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  • Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer
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    Hyejung Cha, Hee Chul Park, Jeong Il Yu, Tae Hyun Kim, Taek-Keun Nam, Sang Min Yoon, Won Sup Yoon, Jun Won Kim, Mi Sook Kim, Hong Seok Jang, Youngmin Choi, Jin Hee Kim, Chul Seung Kay, Inkyung Jung, Jinsil Seong
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    Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-
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    Do-Hoon Kim, Hyojin Chae, Irene Jo, Jaeeun Yoo, Hyeyoung Lee, Woori Jang, Joonhong Park, Gun Dong Lee, Dong-Seok Jeon, Keun Ho Lee, Soo Young Hur, Byung Joo Chae, Byung Joo Song, Myungshin Kim, Yonggoo Kim
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    Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
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    Je-Wook Shin, Byung Kwan Park, Min Jung Kim, Bun Kim, Byung Chang Kim, Sung Chan Park, Kyung Su Han, Dae Kyung Sohn, Jae Hwan Oh
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  • Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center
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  • Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
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  • Phase II Study of Irinotecan and Cisplatin Combination Chemotherapy in Metastatic, Unresectable Esophageal Cancer
    Miso Kim, Bhumsuk Keam, Tae-Min Kim, Hoon-Gu Kim, Jin-Soo Kim, Sung Sook Lee, Seong Hoon Shin, Min Kyoung Kim, Keon Uk Park, Dong-Wan Kim, Hwan Jung Yun, Jong Seok Lee, Dae Seog Heo
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  • Current Trends of Lung Cancer Surgery and Demographic and Social Factors Related to Changes in the Trends of Lung Cancer Surgery: An Analysis of the National Database from 2010 to 2014
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  • Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients
    Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim, Seung-Mo Hong
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    PLOS ONE.2016; 11(4): e0154133.     CrossRef
  • Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
    Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
    PLOS ONE.2016; 11(3): e0150531.     CrossRef
  • The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence
    Aldona Kowalska, Agnieszka Walczyk, Iwona Pałyga, Danuta Gąsior-Perczak, Klaudia Gadawska-Juszczyk, Monika Szymonek, Tomasz Trybek, Katarzyna Lizis-Kolus, Dorota Szyska-Skrobot, Estera Mikina, Stefan Hurej, Janusz Słuszniak, Ryszard Mężyk, Stanisław Góźdź
    PLOS ONE.2016; 11(4): e0153242.     CrossRef
  • UEG Week 2016 Poster Presentations

    United European Gastroenterology Journal.2016; 4(5_suppl): A157.     CrossRef
  • A Comparison of Spatial Pattern Detection Methods for Major Cancer Mortality in Korea
    Jiyu Kim, Myeonggyun Lee, Inkyung Jung
    Asia Pacific Journal of Public Health.2016; 28(6): 539.     CrossRef
  • Survival Analysis of Advanced Non–Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy
    Jongmin Kim, Chong-Kwan Cho, Hwa-Seung Yoo
    Integrative Cancer Therapies.2016; 15(4): 467.     CrossRef
  • Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells
    HAE NIM LEE, HYE YEON JANG, HYEONG JIN KIM, SEONG AH SHIN, GANG SIK CHOO, YOUNG SEOK PARK, SANG KI KIM, JI YOUN JUNG
    International Journal of Molecular Medicine.2016; 37(4): 939.     CrossRef
  • Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report
    SEUNG-GU YEO
    Experimental and Therapeutic Medicine.2016; 11(4): 1465.     CrossRef
  • Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma
    SONG XU, XIAO-MING YI, CHAO-PENG TANG, JING-PING GE, ZHENG-YU ZHANG, WEN-QUAN ZHOU
    Oncology Reports.2016; 36(1): 10.     CrossRef
  • Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
    Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
    World Journal of Gastroenterology.2016; 22(10): 2981.     CrossRef
  • Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging
    Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Seung-ha Lee, Phil-Sang Chung, Bruce J. Tromberg
    Journal of Biomedical Optics.2016; 21(7): 074001.     CrossRef
  • Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
    Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
    Oncotarget.2016; 7(35): 57213.     CrossRef
  • Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX
    Sung Yong Oh, Aesun Shin, Seong-Geun Kim, Jung-Ah Hwang, Seung Hyun Hong, Yeon-Su Lee, Hyuk-Chan Kwon
    Oncotarget.2016; 7(21): 31204.     CrossRef
  • Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China
    Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu, Sung Hoon Noh
    Oncotarget.2016; 7(28): 44660.     CrossRef
  • Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis
    Ahrim Moon, Sung-Im Do, Hyun-Soo Kim, Youn-Wha Kim
    Oncotarget.2016; 7(48): 79319.     CrossRef
  • The Korean guideline for colorectal cancer screening
    Dae Kyung Sohn, Min Ju Kim, Younhee Park, Mina Suh, Aesun Shin, Hee Young Lee, Jong Pil Im, Hyoen-Min Cho, Sung Pil Hong, Baek-hui Kim, Yongsoo Kim, Jeong Wook Kim, Hyun-Soo Kim, Chung Mo Nam, Dong Il Park, Jun Won Um, Soon Nam Oh, Hwan Sub Lim, Hee Jin C
    Journal of the Korean Medical Association.2015; 58(5): 420.     CrossRef
  • The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
    Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong
    BMC Cancer.2015;[Epub]     CrossRef
  • Total and Dietary Calcium Intake and Colorectal Adenoma in Korean Adults
    Ju Eun Seol, Chang Ho Cho, Sung Hi Kim, Jung Eun Lee
    Journal of Cancer Prevention.2015; 20(2): 153.     CrossRef
  • Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia
    Yoon Park, Jeongseon Kim
    Journal of Cancer Prevention.2015; 20(2): 97.     CrossRef
  • The role of surgery in stage IV gastric cancer
    Dong-Seok Han
    Korean Journal of Clinical Oncology.2015; 11(1): 1.     CrossRef
  • Epidemiology of prostate cancer in South Korea
    Hyun Ho Han, Jae Won Park, Joon Chae Na, Byung Ha Chung, Choung-Soo Kim, Woo Jin Ko
    Prostate International.2015; 3(3): 99.     CrossRef
  • Comparison of Quality of Life and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomies
    Hee-Sook Lim, Gyu-Seok Cho, Yoon-Hyung Park, Soon-Kyung Kim
    Clinical Nutrition Research.2015; 4(3): 153.     CrossRef
  • Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine
    Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong
    Yonsei Medical Journal.2015; 56(5): 1177.     CrossRef
  • Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
    Seog Yun Park, Yuh-S Jung, Chang Hwan Ryu, Chang Yoon Lee, You Jin Lee, Eun Kyung Lee, Seok-Ki Kim, Tae Sung Kim, Tae Hyun Kim, Jeyun Jang, Daeyoon Park, Seung Myung Dong, Jae-Goo Kang, Jin Soo Lee, Junsun Ryu
    Endocrine-Related Cancer.2015; 22(4): 679.     CrossRef
  • <i>Helicobacter Pylori</i> Infection and Related Gastrointestinal Diseases
    Chang Seok Bang, Gwang Ho Baik
    The Korean Journal of Medicine.2015; 89(2): 142.     CrossRef
  • Comparison of two different S-1 plus cisplatin dosing schedules as first-line chemotherapy for metastatic and/or recurrent gastric cancer: a multicenter, randomized phase III trial (SOS)
    M.-H. Ryu, E. Baba, K.H. Lee, Y.I. Park, N. Boku, I. Hyodo, B.-H. Nam, T. Esaki, C. Yoo, B.-Y. Ryoo, E.-K. Song, S.-H. Cho, W.K. Kang, S.H. Yang, D.Y. Zang, D.B. Shin, S.R. Park, K. Shinozaki, T. Takano, Y.-K. Kang
    Annals of Oncology.2015; 26(10): 2097.     CrossRef
  • Has the National Cancer Screening Program reduced income inequalities in screening attendance in South Korea?
    Sujin Kim, Soonman Kwon, S. V. Subramanian
    Cancer Causes & Control.2015; 26(11): 1617.     CrossRef
  • Lung Cancer Screening: Update
    Hyae Young Kim
    Journal of the Korean Society of Radiology.2015; 73(3): 137.     CrossRef
  • Laparoscopic Sentinel Node Navigation Surgery for Gastric Cancer
    Keun Won Ryu
    The Journal of Minimally Invasive Surgery.2015; 18(3): 63.     CrossRef
  • It needs adaptation to the 2015 Korean guideline for breast cancer screening
    Jong-Myon Bae
    Journal of the Korean Medical Association.2015; 58(9): 833.     CrossRef
  • Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
    Jong-Myon Bae, Eun Hee Kim
    Journal of Preventive Medicine and Public Health.2015; 48(5): 225.     CrossRef
  • Laparoscopic Total Gastrectomy in Elderly Patients (≥70 Years) with Gastric Carcinoma: A Retrospective Study
    Hong Sung Jung, Young Kyu Park, Seong Yeob Ryu, Oh Jeong
    Journal of Gastric Cancer.2015; 15(3): 176.     CrossRef
  • Anti-Cancer Effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells
    Soojin Lee, Huijin Gim, Ji Hwan Shim, Hyun Soo Park, Byung Joo Kim
    Herbal Formula Science.2015; 23(1): 101.     CrossRef
  • Motivos de consulta al servicio de urgencias de los pacientes adultos con enfermedades hemato-oncológicas en un hospital de cuarto nivel de atención
    Rocio Mariño, Sergio Cervera, Lizet Moreno, Oswaldo Sánchez
    Revista Colombiana de Cancerología.2015; 19(4): 204.     CrossRef
  • Educational Needs for Sexual Health and Its Effect on Depression and the Quality of Life in Patients with Prostate Cancer
    Soonyoung Oh, Eunjung Ryu
    Asian Oncology Nursing.2015; 15(3): 163.     CrossRef
  • Factors Associated with Human Papillomavirus Vaccination and Intention among Male and Female College Students
    Seung Yeun Lee, Mi Ah Han, Jong Park, So Yeon Ryu
    Korean Journal of Health Promotion.2015; 15(3): 141.     CrossRef
  • Prostate-specific antigen kinetics after stereotactic body radiotherapy as monotherapy or boost after whole pelvic radiotherapy for localized prostate cancer
    Hun Jung Kim, Jung Hoon Phak, Woo Chul Kim
    Prostate International.2015; 3(4): 118.     CrossRef
  • The Impact of Low Adherence to the Low-iodine Diet on the Efficacy of the Radioactive Iodine Ablation Therapy
    Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
    Clinical Nutrition Research.2015; 4(4): 267.     CrossRef
  • Hyperuricemia as a Novel Risk Factor for Colorectal Adenomatous Polyp
    Jung Won Lee, Jong Pil Im
    The Korean Journal of Gastroenterology.2015; 66(4): 183.     CrossRef
  • Trends in Colorectal Cancer Incidence in Daejeon and Chungcheongnam-do, South Korea (2000-2012)
    Soon-Young Kim, In-Sun Kweon, Jung-A Kim, Tae-Yong Lee, Hae-Sung Nam
    Journal of agricultural medicine and community health.2015; 40(3): 115.     CrossRef
  • Time to learn from the past and prepare for the future in <i>Helicobacter pylori</i> eradication
    Chang Seok Bang, Gwang Ho Baik
    The Korean Journal of Internal Medicine.2015; 30(6): 789.     CrossRef
  • Effects of a Patient Educational Video Program on Bowel Preparation Prior to Colonoscopy
    You Young Cho, Hyeon Ok Kim
    Journal of Korean Academy of Nursing.2015; 45(5): 704.     CrossRef
  • Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey
    Sang Hwa Lee, Wan Seop Kim, Yoo Duk Choi, Jeong Wook Seo, Joung Ho Han, Mi Jin Kim, Lucia Kim, Geon Kook Lee, Chang Hun Lee, Mee Hye Oh, Gou Young Kim, Sun Hee Sung, Kyo Young Lee, Sun Hee Chang, Mee Sook Rho, Han Kyeom Kim, Soon Hee Jung, Se Jin Jang
    Journal of Pathology and Translational Medicine.2015; 49(6): 481.     CrossRef
  • Modifiable risk factors of lung cancer in “never-smoker” women
    Jong-Myon Bae
    Epidemiology and Health.2015; 37: e2015047.     CrossRef
  • Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies
    Jong-Myon Bae, Eun Hee Kim
    Journal of Preventive Medicine and Public Health.2015; 48(6): 280.     CrossRef
  • Thyroid Cancer: We Need a Carcinogen-specific Genome Study
    Jong-Myon Bae
    Journal of Korean Medical Science.2015; 30(12): 1920.     CrossRef
  • Family Caregivers’ Quality of Life, Depression and Anxiety according to Symptom Control in Hospice Patients
    Yun Hee Kim, Seung Hun Lee, Ho Seop Lim, Young Jin Choi, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Dong Wook Jeong, Kyoung Hwa Yu
    The Korean Journal of Hospice and Palliative Care.2015; 18(4): 314.     CrossRef
  • A Case of the Advanced Non-Small Cell Lung Cancer Patient Who Showed Symptoms Improvement
    So-Ra Park, Soo-Min Lee, Soo-Kyung Lee
    Journal of Sasang Constitutional Medicine.2015; 27(3): 326.     CrossRef
  • Multiple cores of high grade prostatic intraepithelial neoplasia and any core of atypia on first biopsy are significant predictor for cancer detection at a repeat biopsy
    Tae Sun Kim, Kwang Jin Ko, Seung Jea Shin, Hyun Soo Ryoo, Wan Song, Hyun Hwan Sung, Deok Hyun Han, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Kyu Sung Lee, Sung Won Lee, Hyun Moo Lee, Han Yong Choi, Hwang Gyun Jeon
    Korean Journal of Urology.2015; 56(12): 796.     CrossRef
  • An Iodine Database for Common Korean Foods and the Association between Iodine Intake and Thyroid Disease in Korean Adults
    Mi-Rhan Han, Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
    International Journal of Thyroidology.2015; 8(2): 170.     CrossRef
  • Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea
    Jin-Kyoung Oh, Min Kyung Lim, E Hwa Yun, Min-Ho Choi, Sung-Tae Hong, Soung-Hoon Chang, Sue Kyung Park, Sung-Il Cho, Dong-Hyun Kim, Keun-Young Yoo, Hai-Rim Shin
    International Journal of Epidemiology.2015; : dyv302.     CrossRef
  • Comparative evaluation of the mutagenicity and genotoxicity of smoke condensate derived from Korean cigarettes
    Ha Ryong Kim, Jeong Eun Lee, Mi Ho Jeong, Seong Jin Choi, Kyuhong Lee, Kyu Hyuck Chung
    Environmental Health and Toxicology.2015; 30: e2015014.     CrossRef
  • Adherence to Guidelines for Cancer Survivors and Health-Related Quality of Life among Korean Breast Cancer Survivors
    Sihan Song, Eunkyung Hwang, Hyeong-Gon Moon, Dong-Young Noh, Jung Lee
    Nutrients.2015; 7(12): 10307.     CrossRef
  • Microflora of upper gastrointestinal tract in gastric cancer patients
    Dongwoo Kang, Jong Won Kim, Seung Ho Choi
    Korean Journal of Clinical Oncology.2015; 11(2): 87.     CrossRef
  • Minimally invasive surgery in gastric cancer
    Do Joong Park, Sang Hoon Ahn, Hyung-Ho Kim
    Korean Journal of Clinical Oncology.2015; 11(2): 37.     CrossRef
  • Second-Line Chemotherapy in Advanced Biliary Tract Cancer: A Retrospective Analysis
    Hyun Jung Kim, Jina Yun, Han Jo Kim, Kyoung Ha Kim, Se Hyung Kim, Sang-Cheol Lee, Sang Byung Bae, Chan Kyu Kim, Nam Su Lee, Kyu Taek Lee, Seong Kyu Park, Jong-Ho Won, Hyun Jong Choi, Jong Ho Moon, Dae Sik Hong
    Soonchunhyang Medical Science.2015; 21(2): 75.     CrossRef
  • Age Over 80 is a Possible Risk Factor for Postoperative Morbidity After a Laparoscopic Resection of Colorectal Cancer
    Taekhyun Kang, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Won Kon Han, Kyung Uk Jung
    Annals of Coloproctology.2015; 31(6): 228.     CrossRef
  • Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
    Jong-Myon Bae, Eun Hee Kim
    Epidemiology and Health.2015; 37: e2015052.     CrossRef
  • Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces cell cycle arrest and apoptosis via the downregulation of Akt in human lung cancer cells
    HYUN SOOK LIM, YONG JUNG KANG, BOKYUNG SUNG, SEON HEE KIM, MIN JEONG KIM, HYE RIM KIM, SEONG JIN KIM, YUNG HYUN CHOI, HYUNG RYONG MOON, HAE YOUNG CHUNG, NAM DEUK KIM
    Oncology Reports.2015; 34(5): 2431.     CrossRef
  • Gluten Psychosis: Confirmation of a New Clinical Entity
    Elena Lionetti, Salvatore Leonardi, Chiara Franzonello, Margherita Mancardi, Martino Ruggieri, Carlo Catassi
    Nutrients.2015; 7(12): 5532.     CrossRef
  • Chemical Composition and Antiproliferative Activity of Supercritical Extract of Immature Citrus Peel in human cervical carcinoma HeLa cells
    Jeong Yong Moon, YeonWoo Song, Ho Bong Hyun, Somi KimCho
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(12): 8836.     CrossRef
  • Prognosis of Cervical Cancer in the Era of Concurrent Chemoradiation from National Database in Korea: A Comparison between Squamous Cell Carcinoma and Adenocarcinoma
    Jung-Yun Lee, Young Tae Kim, Sunghoon Kim, Boram Lee, Myong Cheol Lim, Jae-Weon Kim, Young-Joo Won, Jose G. Trevino
    PLOS ONE.2015; 10(12): e0144887.     CrossRef
  • Clinical Characteristics and Incidence of Thyroid Nodule in the Male Population for Health Check-up
    Yeon Jin Jeon, Young Teag Koh, Seung Jong Oh, Min Young Koo
    Korean Journal of Endocrine Surgery.2015; 15(4): 93.     CrossRef
  • Clinical Characteristics and Incidence of Thyroid Nodule in the Male Population for Health Check-up
    Yeon Jin Jeon, Young Teag Koh, Seung Jong Oh, Min Young Koo
    Korean Journal of Endocrine Surgery.2015; 15(4): 93.     CrossRef
  • Metabolic Syndrome in Korean Cancer Survivors and Family Members: A Study in a Health Promotion Center
    Jin Young Shin, Yoon Ho Choi, Yun Mi Song
    Nutrition and Cancer.2015; 67(7): 1075.     CrossRef
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