Cancer Research and Treatment

Original Articles

Validating the Korean Geriatric Assessment Tool in Elderly Multiple Myeloma Patients: A Multicenter Study: Ji Yun Lee, Sang-A Kim, Youngil Koh, Ho-Young Yhim, Gyeong-Won Lee, Chang-Ki Min, Young Rok Do, Hyo Jung Kim, Sung Hwa Bae, Hyeon-Seok Eom, Sung-Hoon Jung, Hyunkyung Park, Seung-Hyun Nam, Ji Hyun Lee, Sung-Hyun Kim, Hyun Jung Lee, Young Seob Park, Soo-Mee Bang; Received January 15, 2025 Accepted February 20, 2025 Published online February 21, 2025; DOI: https://doi.org/10.4143/crt.2025.066 [Accepted]

Abstract PDF: Purpose
This study evaluates the Korean Cancer Study Group Geriatric Score-7 (KG-7) frailty screening tool's effectiveness in elderly multiple myeloma (MM) patients to prevent under and over-treatment.
Materials and Methods
This prospective pilot cohort study included 100 elderly patients aged 70 and older with newly diagnosed MM who had not undergone transplantation from August 2020 to January 2022.
Results
The median age was 77 years, and 73% of patients were classified at International Staging System (ISS) stages 2 or 3. Using a 5-point cutoff on the KG-7 index (non-frail, score ≥ 5; frail, score < 5), 31% were categorized as frail. After a median follow-up of 26.8 months, the 3-year overall survival rate was 73.0%. There was no statistically significant association between any frailty index and the risk of death. However, frail patients defined by the simplified frailty index (HR, 2.49; 95% CI, 1.09–5.95; p=0.030) and by KG-7 (HR, 2.43; 95% CI, 1.03–5.86; p=0.043) had a significantly higher risk of grade 3–4 non-hematologic toxicity, whereas the IMWG definition did not. Over a 24-month tracking period, vulnerability as measured by KG-7 either improved or deteriorated.
Conclusion
The pilot study, which had a limited number of participants, did not demonstrate KG-7’s effectiveness in predicting survival; however, it successfully predicted severe non-hematologic toxicities. We plan to conduct larger studies in elderly MM patients to determine whether KG-7 can help tailor their treatment regimens.

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Machine Learning–Based Prognostic Gene Signature for Early Triple-Negative Breast Cancer: Ju Won Kim, Jonghyun Lee, Sung Hak Lee, Sangjeong Ahn, Kyong Hwa Park; Received September 26, 2024 Accepted November 18, 2024 Published online November 19, 2024; DOI: https://doi.org/10.4143/crt.2024.937 [Epub ahead of print]

Abstract PDF Supplementary Material PubReader ePub: Purpose
This study aimed to develop a machine learning–based approach to identify prognostic gene signatures for early-stage triple-negative breast cancer (TNBC) using next-generation sequencing data from Asian populations.
Materials and Methods
We utilized next-generation sequencing data to analyze gene expression profiles and identify potential biomarkers. Our methodology involved integrating various machine learning techniques, including feature selection and model optimization. We employed logistic regression, Kaplan-Meier survival analysis, and receiver operating characteristic (ROC) curves to validate the identified gene signatures.
Results
We identified a gene signature significantly associated with relapse in TNBC patients. The predictive model demonstrated robustness and accuracy, with an area under the ROC curve of 0.9087, sensitivity of 0.8750, and specificity of 0.9231. The Kaplan-Meier survival analysis revealed a strong association between the gene signature and patient relapse, further validated by logistic regression analysis.
Conclusion
This study presents a novel machine learning-based prognostic tool for TNBC, offering significant implications for early detection and personalized treatment. The identified gene signature provides a promising approach for improving the management of TNBC, contributing to the advancement of precision oncology.

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Hematologic malignancy

The Role of Direct Oral Anticoagulants in Managing Myeloproliferative Neoplasms Patients: Ji Yun Lee, Ju-Hyun Lee, Woochan Park, Jeongmin Seo, Minsu Kang, Eun Hee Jung, Sang-A Kim, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang; Cancer Res Treat. 2025;57(2):612-620. Published online September 20, 2024; DOI: https://doi.org/10.4143/crt.2024.738

Abstract PDF Supplementary Material PubReader ePub

Purpose
Thrombosis and bleeding significantly affect morbidity and mortality in myeloproliferative neoplasms (MPNs). The efficacy and safety of direct oral anticoagulants (DOACs) in MPN patients remain uncertain.
Materials and Methods
We conducted a large, retrospective, nationwide cohort study using the Korean Health Insurance Review and Assessment Service database from 2010 to 2021.
Results
Out of the 368 MPN patients included in the final analysis, 62.8% were treated with DOACs for atrial fibrillation (AF), and 37.2% for venous thromboembolism (VTE). The AF group was statistically older with higher CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke, transient ischemic attack, or thromboembolism, vascular disease, age 65-74 years, sex category [female]) scores compared to the VTE group. Antiplatelet agents were used in 51.1% of cases, and cytoreductive drugs in 79.3%, with hydroxyurea being the most common (64.9%). The median follow-up was 22.3 months, with 1-year cumulative incidence rates of thrombosis and bleeding at 11.1% and 3.7%, respectively. Multivariate analysis identified CHA2DS2-VASc scores ≥ 3 (hazard ratio [HR], 3.48), concomitant antiplatelet use (HR, 2.57), and cytoreduction (HR, 2.20) as significant thrombosis risk factors but found no significant predictors for major bleeding.
Conclusion
Despite the limitations of retrospective data, DOAC treatment in MPN patients seems effective and has an acceptable bleeding risk.

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Survey of Clinical Practice in Chronic Myeloproliferative Neoplasms in Croatia: A Study by the MPN Working Group Party of the Croatian Cooperative Group for Hematologic Diseases (KROHEM)
Ivan Krecak, Marko Lucijanic, Rajko Kusec
Journal of Clinical Medicine.2025; 14(5): 1524. CrossRef

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Breast cancer

Molecular Classification of Breast Cancer Using Weakly Supervised Learning: Wooyoung Jang, Jonghyun Lee, Kyong Hwa Park, Aeree Kim, Sung Hak Lee, Sangjeong Ahn; Cancer Res Treat. 2025;57(1):116-125. Published online June 25, 2024; DOI: https://doi.org/10.4143/crt.2024.113

Abstract PDF Supplementary Material PubReader ePub: Purpose
The molecular classification of breast cancer is crucial for effective treatment. The emergence of digital pathology has ushered in a new era in which weakly supervised learning leveraging whole-slide images has gained prominence in developing deep learning models because this approach alleviates the need for extensive manual annotation. Weakly supervised learning was employed to classify the molecular subtypes of breast cancer.
Materials and Methods
Our approach capitalizes on two whole-slide image datasets: one consisting of breast cancer cases from the Korea University Guro Hospital (KG) and the other originating from The Cancer Genomic Atlas dataset (TCGA). Furthermore, we visualized the inferred results using an attention-based heat map and reviewed the histomorphological features of the most attentive patches.
Results
The KG+TCGA-trained model achieved an area under the receiver operating characteristics value of 0.749. An inherent challenge lies in the imbalance among subtypes. Additionally, discrepancies between the two datasets resulted in different molecular subtype proportions. To mitigate this imbalance, we merged the two datasets, and the resulting model exhibited improved performance. The attentive patches correlated well with widely recognized histomorphologic features. The triple-negative subtype has a high incidence of high-grade nuclei, tumor necrosis, and intratumoral tumor-infiltrating lymphocytes. The luminal A subtype showed a high incidence of collagen fibers.
Conclusion
The artificial intelligence (AI) model based on weakly supervised learning showed promising performance. A review of the most attentive patches provided insights into the predictions of the AI model. AI models can become invaluable screening tools that reduce costs and workloads in practice.

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Gastrointestinal cancer

Longitudinal Comparative Analysis of Circulating Tumor DNA and Matched Tumor Tissue DNA in Patients with Metastatic Colorectal Cancer Receiving Palliative First-Line Systemic Anti-Cancer Therapy: Seung-been Lee, Ji-Won Kim, Hong-Geun Kim, Sung-Hyun Hwang, Kui-Jin Kim, Ju Hyun Lee, Jeongmin Seo, Minsu Kang, Eun Hee Jung, Koung Jin Suh, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Nak-Jung Kwon, Keun-Wook Lee; Cancer Res Treat. 2024;56(4):1171-1182. Published online April 29, 2024; DOI: https://doi.org/10.4143/crt.2024.016

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study aimed to compare tumor tissue DNA (ttDNA) and circulating tumor DNA (ctDNA) to explore the clinical applicability of ctDNA and to better understand clonal evolution in patients with metastatic colorectal cancer undergoing palliative first-line systemic therapy.
Materials and Methods
We performed targeted sequencing analysis of 88 cancer-associated genes using germline DNA, ctDNA at baseline (baseline-ctDNA), and ctDNA at progressive disease (PD-ctDNA). The results were compared with ttDNA data.
Results
Among 208 consecutively enrolled patients, we selected 84 (41 males; median age, 59 years; range, 35 to 90 years) with all four sample types available. A total of 202 driver mutations were found in 34 genes. ttDNA exhibited the highest mutation frequency (n=232), followed by baseline-ctDNA (n=155) and PD-ctDNA (n=117). Sequencing ctDNA alongside ttDNA revealed additional mutations in 40 patients (47.6%). PD-ctDNA detected 13 novel mutations in 10 patients (11.9%) compared to ttDNA and baseline-ctDNA. Notably, seven mutations in five patients (6.0%) were missense or nonsense mutations in APC, TP53, SMAD4, and CDH1 genes. In baseline-ctDNA, higher maximal variant allele frequency (VAF) values (p=0.010) and higher VAF values of APC (p=0.012), TP53 (p=0.012), and KRAS (p=0.005) mutations were significantly associated with worse overall survival.
Conclusion
While ttDNA remains more sensitive than ctDNA, our ctDNA platform demonstrated validity and potential value when ttDNA was unavailable. Post-treatment analysis of PD-ctDNA unveiled new pathogenic mutations, signifying cancer’s clonal evolution. Additionally, baseline-ctDNA’s VAF values were prognostic after treatment.

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Precision-Guided Durable Response From Venetoclax With Decitabine in a Patient With a Metastatic Refractory IDH2 -Mutant Cholangiocarcinoma
Eylül Özgü, Ünal Metin Tokat, Ashkan Adibi, Şevval Nur Bilgiç, Esranur Aydın, Onur Tutar, Mutlu Demiray
JCO Precision Oncology.2025;[Epub] CrossRef
Evolution of Neo-RAS-WT in Circulating Tumor DNA from First-Line to Subsequent Therapies in Metastatic Colorectal Cancer
Marco Siringo, Michela De Meo, Irene Bottillo, Paola Grammatico, Enrico Cortesi, Chiara Nicolazzo, Paola Gazzaniga
Cancers.2025; 17(7): 1070. CrossRef

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Correspondence

Bridging the Gap between Trial Adverse Events and Real-World Data: Sang Hyuk Kim, Hyun Lee, Dong Won Park; Cancer Res Treat. 2024;56(3):972-973. Published online January 10, 2024; DOI: https://doi.org/10.4143/crt.2024.019

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Original Articles

Hematologic malignancy

Pembrolizumab for Patients with Relapsed or Refractory Extranodal NK/T-Cell Lymphoma in Korea: Ji Yun Lee, Ji Hyun Kwon, Joon Young Hur, Jun Ho Yi, Ji Hyun Lee, Hyungwoo Cho, Young Rok Do, Jae-Cheol Jo, Hye Jin Kang, Yougil Koh, Won Sik Lee, Sung Nam Lim, Sang Eun Yoon, Seok Jin Kim, Jeong-Ok Lee; Cancer Res Treat. 2024;56(2):681-687. Published online November 10, 2023; DOI: https://doi.org/10.4143/crt.2023.1042

Abstract PDF PubReader ePub

Purpose
Programmed death-1 blockade with pembrolizumab has shown promising activity in relapsed/refractory (R/R) extranodal natural killer/T-cell lymphoma (NKTCL), but studies are limited, with small patient numbers.
Materials and Methods
Thirteen institutes involved with the Consortium for Improving Survival of Lymphoma, a Korean lymphoma study group, collected the clinical data of 59 patients treated with pembrolizumab as salvage therapy between 2016 and 2022.
Results
The median age of the patients was 60 years (range, 22 to 87 years), and 76.3% had advanced Ann Abor stage disease. Pembrolizumab was given to 35.6%, 40.7%, and 23.7% of the patients as second-, third-, and fourth- or higher-line chemotherapy, respectively. The overall response rate was 40.7%, with 28.8% having complete response. The estimated 2-year progression-free survival (PFS) and overall survival rates for all patients were 21.5% and 28.7%, respectively; for responders, the rates were 53.0% and 60.7%, respectively. Although not statistically significant, Eastern Cooperative Oncology Group performance status ≥ 2 (hazard ratio [HR], 1.91; 95% confidence interval [95% CI], 0.93 to 3.94; p=0.078) and stage III or IV disease (HR, 2.59; 95% CI, 0.96 to 6.96; p=0.060) were associated with a trend toward shorter PFS in multivariate analysis. Grade 3 or 4 adverse events (AEs) were noted in 12 patients (20.3%); neutropenia (10.2%), fatigue (6.8%), and pneumonitis (5.1%) were most common AEs.
Conclusion
In conclusion, while pembrolizumab had a modest effect on patients with R/R NKTCL, it may be a useful salvage therapy for patients with localized disease and good performance status.

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An evaluation of sugemalimab for the treatment of relapsed or refractory extranodal natural killer T-cell lymphoma
Yingfang Feng, Xia Liu, Jingwei Yu, Zheng Song, Lanfang Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang
Expert Opinion on Biological Therapy.2025; 25(1): 9. CrossRef
Pembrolizumab

Reactions Weekly.2024; 2025(1): 390. CrossRef

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General

Impact of Patient Sex on Adverse Events and Unscheduled Utilization of Medical Services in Cancer Patients Undergoing Adjuvant Chemotherapy: A Multicenter Retrospective Cohort Study: Songji Choi, Seyoung Seo, Ju Hyun Lee, Koung Jin Suh, Ji-Won Kim, Jin Won Kim, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jwa Hoon Kim, Tae Won Kim, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Sang-We Kim, Dae Ho Lee, Jae Cheol Lee, Chang-Min Choi, Shinkyo Yoon, Su-Jin Koh, Young Joo Min, Yongchel Ahn, Hwa Jung Kim, Jin Ho Baek, Sook Ryun Park, Jee Hyun Kim; Cancer Res Treat. 2024;56(2):404-413. Published online November 7, 2023; DOI: https://doi.org/10.4143/crt.2023.784

Abstract PDF Supplementary Material PubReader ePub

Purpose
The female sex is reported to have a higher risk of adverse events (AEs) from cytotoxic chemotherapy. Few studies examined the sex differences in AEs and their impact on the use of medical services during adjuvant chemotherapy. This sub-study aimed to compare the incidence of any grade and grade ≥ 3 AEs, healthcare utilization, chemotherapy completion rate, and dose intensity according to sex.
Materials and Methods
This is a sub-study of a multicenter cohort conducted in Korea that evaluated the impact of healthcare reimbursement on AE evaluation in patients who received adjuvant chemotherapy between September 2013 and December 2016 at four hospitals in Korea.
Results
A total of 1,170 patients with colorectal, gastric, or non–small cell lung cancer were included in the study. Female patients were younger, had fewer comorbidities, and experienced less postoperative weight loss of > 10%. Females had significantly higher rates of any grade AEs including nausea, abdominal pain, stomatitis, vomiting, and neutropenia, and experienced more grade ≥ 3 neutropenia, nausea, and vomiting. The dose intensity of chemotherapy was significantly lower in females, and they also experienced more frequent dose reduction after the first cycle. Moreover, female patients receiving platinum-containing regimens had significantly higher rates of unscheduled outpatient visits.
Conclusion
Our study found that females experienced a higher incidence of multiple any-grade AEs and severe neutropenia, nausea, and vomiting, across various cancer types, leading to more frequent dose reductions. Physicians should be aware of sex differences in AEs for chemotherapy decisions.

Citations

Citations to this article as recorded by

Cancer care for transgender and gender‐diverse people: Practical, literature‐driven recommendations from the Multinational Association of Supportive Care in Cancer
Elizabeth J. Cathcart‐Rake, Alexandre Chan, Alvaro Menendez, Denise Markstrom, Carla Schnitzlein, Yee Won Chong, Don S. Dizon
CA: A Cancer Journal for Clinicians.2025; 75(1): 68. CrossRef
Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system in male and female rats
Chiara Di Marino, Álvaro Llorente-Berzal, Alba M. Diego, Ariadni Bella, Laura Boullon, Esther Berrocoso, Michelle Roche, David P. Finn
Frontiers in Pharmacology.2025;[Epub] CrossRef
[Translated article] Toxicity of the FOLFOX-6 regimen, with or without 5-fluorouracil bolus, in metastatic colorectal cancer
María Teresa Garrido Martínez, María Rodríguez Jorge, Ignacio García Giménez, María Isabel Guzmán Ramos, Salvador Grutzmancher Sáiz, Victoria Aviñó Tarazona
Farmacia Hospitalaria.2025;[Epub] CrossRef
The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma
Jun Kawashima, Yutaka Endo, Selamawit Woldesenbet, Mujtaba Khalil, Miho Akabane, François Cauchy, Feng Shen, Shishir Maithel, Irinel Popescu, Minoru Kitago, Matthew J. Weiss, Guillaume Martel, Carlo Pulitano, Luca Aldrighetti, George Poultsides, Andrea Ru
Annals of Surgical Oncology.2025; 32(6): 4341. CrossRef
Toxicidad del esquema FOLFOX-6, asociado o no a bolo de 5-fluorouracilo, en cáncer colorrectal metastásico
María Teresa Garrido Martínez, María Rodríguez Jorge, Ignacio García Giménez, María Isabel Guzmán Ramos, Salvador Grutzmancher Sáiz, Victoria Aviñó Tarazona
Farmacia Hospitalaria.2024;[Epub] CrossRef

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Genitourinary cancer

Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations: Boram Song, Seok Hyun Lee, Jeong Hwan Park, Kyung Chul Moon; Cancer Res Treat. 2024;56(1):280-293. Published online September 11, 2023; DOI: https://doi.org/10.4143/crt.2023.577

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study aimed to evaluate the molecular features of clear cell adenocarcinoma (CCA) of the urinary tract and investigate its pathogenic pathways and possible actionable targets.
Materials and Methods
We retrospectively collected the data of patients with CCA between January 1999 and December 2016; the data were independently reviewed by two pathologists. We selected five cases of urinary CCA, based on the clinicopathological features. We analyzed these five cases by whole exome sequencing (WES) and subsequent bioinformatics analyses to determine the mutational spectrum and possible pathogenic pathways.
Results
All patients were female with a median age of 62 years. All tumors were located in the urethra and showed aggressive behavior with disease progression. WES revealed several genetic alterations, including driver gene mutations (AMER1, ARID1A, CHD4, KMT2D, KRAS, PBRM1, and PIK3R1) and mutations in other important genes with tumor-suppressive and oncogenic roles (CSMD3, KEAP1, SMARCA4, and CACNA1D). We suggest putative pathogenic pathways (chromatin remodeling pathway, mitogen-activated protein kinase signaling pathway, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Wnt/β-catenin pathway) as candidates for targeted therapies.
Conclusion
Our findings shed light on the molecular background of this extremely rare tumor with poor prognosis and can help improve treatment options.

Citations

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Urethral clear cell adenocarcinoma in an adult female: A rare case report
Yacob Sheiferawe Seman, Michael Teklehaimanot Abera, Fadil Nuredin Abrar, Tesfaye Kebede Legesse, Mesfin Asefa Tola, Tsiyon Nigusie Alemu
Urology Case Reports.2025; 58: 102882. CrossRef
Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review
Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang
Frontiers in Oncology.2025;[Epub] CrossRef
Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population
Ye He, Binyao Li, Xinying Zhao, Lingling Pan, Yanqing Liu, Chaoting Lan, Fuming Deng, Wen Fu, Yan Zhang, Xiaoyu Zuo
Journal of Pediatric Urology.2024; 20(3): 438.e1. CrossRef
The L‐type calcium channel CaV1.3: A potential target for cancer therapy
Xuerun Liu, Boqiang Shen, Jingyi Zhou, Juan Hao, Jianliu Wang
Journal of Cellular and Molecular Medicine.2024;[Epub] CrossRef

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Lung and Thoracic cancer

A Randomized Phase II Study of Irinotecan Plus Cisplatin with or without Simvastatin in Ever-Smokers with Extended Disease Small Cell Lung Cancer: Youngjoo Lee, Soo-Hyun Lee, Geon Kook Lee, Eun Jin Lim, Ji-Youn Han; Cancer Res Treat. 2023;55(3):885-893. Published online March 20, 2023; DOI: https://doi.org/10.4143/crt.2023.283

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study evaluated whether an addition of simvastatin to chemotherapy improves survival in ever-smokers with extensive disease (ED)–small cell lung cancer (SCLC).
Materials and Methods
This is an open-label randomized phase II study conducted in National Cancer Center (Goyang, Korea). Chemonaive patients with ED-SCLC, smoking history (≥ 100 cigarettes lifetime), and Eastern Cooperative Oncology Group performance status of ≤ 2 were eligible. Patients were randomized to receive irinotecan plus cisplatin alone or with simvastatin (40 mg once daily orally) for a maximum of six cycles. Primary endpoint was the the 1-year survival rate.
Results
Between September 16, 2011, and September 9, 2021, 125 patients were randomly assigned to the simvastatin (n=62) or control (n=63) groups. The median smoking pack year was 40 years. There was no significant difference in the 1-year survival rate between the simvastatin and control groups (53.2% vs. 58.7%, p=0.535). The median progression-free survival and overall survival between the simvastatin arm vs. the control groups were 6.3 months vs. 6.4 months (p=0.686), and 14.4 months vs. 15.2 months, respectively (p=0.749). The incidence of grade 3-4 adverse events was 62.9% in the simvastatin group and 61.9% in the control group. In the exploratory analysis of lipid profiles, patients with hypertriglyceridemia had significantly higher 1-year survival rates than those with normal triglyceride levels (80.0% vs. 52.7%, p=0.046).
Conclusion
Addition of simvastatin to chemotherapy provided no survival benefit in ever-smokers with ED-SCLC. Hypertriglyceridemia may be associated with better prognosis in these patient population.

Citations

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Cardiovascular/anti‐inflammatory drugs repurposed for treating or preventing cancer: A systematic review and meta‐analysis of randomized trials
David J. Benjamin, Alyson Haslam, Vinay Prasad
Cancer Medicine.2024;[Epub] CrossRef
Repurposing simvastatin in cancer treatment: an updated review on pharmacological and nanotechnological aspects
Nargis Ara, Abdul Hafeez, Shom Prakash Kushwaha
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(10): 7377. CrossRef
Strategies to Target Chemoradiotherapy Resistance in Small Cell Lung Cancer
Tony Yu, Benjamin H. Lok
Cancers.2024; 16(20): 3438. CrossRef
β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers
Pedro Gabriel Senger Braga, Janaína da Silva Vieira, Aline Rachel Bezerra Gurgel, Patricia Chakur Brum
Frontiers in Pharmacology.2024;[Epub] CrossRef
Statins—From Fungi to Pharmacy
Anna Sadowska, Patryk Osiński, Alicja Roztocka, Karolina Kaczmarz-Chojnacka, Ewa Zapora, Diana Sawicka, Halina Car
International Journal of Molecular Sciences.2023; 25(1): 466. CrossRef

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Breast cancer

PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients: Ju Won Kim, Ah Reum Lim, Ji Young You, Jung Hyun Lee, Sung Eun Song, Nam Kwon Lee, Seung Pil Jung, Kyu Ran Cho, Cheol Yong Kim, Kyong Hwa Park; Cancer Res Treat. 2023;55(2):531-541. Published online September 7, 2022; DOI: https://doi.org/10.4143/crt.2022.221

Abstract PDF Supplementary Material PubReader ePub

Purpose
Mutations in the PIK3CA gene occur frequently in breast cancer patients. Activating PIK3CA mutations confer resistance to human epidermal growth factor receptor 2 (HER2)-targeted treatments. In this study, we investigated whether PIK3CA mutations were correlated with treatment response or duration in patients with HER2-positive (HER2+) breast cancer.
Materials and Methods
We retrospectively reviewed the clinical information of patients with HER2+ breast cancer who received HER2-targeted therapy for early-stage or metastatic cancers. The pathologic complete response (pCR), progression-free survival (PFS), and overall survival were compared between patients with wild-type PIK3CA (PIK3CAw) and those with mutated PIK3CA (PIK3CAm). Next-generation sequencing was combined with examination of PFS associated with anti-HER2 monoclonal antibody (mAb) treatment.
Results
Data from 90 patients with HER2+ breast cancer were analyzed. Overall, 34 (37.8%) patients had pathogenic PIK3CA mutations. The pCR rate of the PIK3CAm group was lower than that of the PIK3CAw group among patients who received neoadjuvant chemotherapy for early-stage cancer. In the metastatic setting, the PIK3CAm group showed a significantly shorter mean PFS (mPFS) with first-line anti-HER2 mAb. The mPFS of second-line T-DM1 was lower in the PIK3CAm group than that in the PIK3CAw group. Sequencing revealed differences in the mutational landscape between PIK3CAm and PIK3CAw tumors.
Conclusion
Patients with HER2+ breast cancer with activating PIK3CA mutations had lower pCR rates and shorter PFS with palliative HER2-targeted therapy than those with wild-type PIK3CA. Precise targeted-therapy is needed to improve survival of patients with HER2+/PIK3CAm breast cancer.

Citations

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Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms
Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala, Andrew A. Davis
Oncotarget.2025; 16(1): 11. CrossRef
The Effect and Treatment of PIK3CA Mutations in Breast Cancer: Current Understanding and Future Directions
Young-Bin Cho, Kyoung-Sik Park
Medicina.2025; 61(3): 518. CrossRef
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes
Yan Wisnu Prajoko, Didik Setyo Heriyanto, Bayu Tirta Dirja, Susanto Susanto, Vincent Lau, Andrew Nobiantoro Gunawan, Brigitta Natasya Halim, Nur Dina Amalina, Rashi Kalra
PLOS One.2025; 20(5): e0322154. CrossRef
Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis
Qian Ma, Bai Wei, Bi-Cheng Wang, Ganxin Wang, Xuan Zhou, Yan Wang
Oncology Letters.2024;[Epub] CrossRef
A novel PIK3CA hot-spot mutation in breast cancer patients detected by HRM-COLD-PCR analysis
Saoussen Debouki-Joudi, Wala Ben Kridis, Fatma Trifa, Wajdi Ayadi, Abdelmajid Khabir, Tahia Sellami-Boudawara, Jamel Daoud, Afef Khanfir, Raja Mokdad-Gargouri
Breast Disease.2024; 43(1): 213. CrossRef
Liquid Biopsy in the Clinical Management of Cancers
Ho-Yin Ho, Kei-See (Kasey) Chung, Chau-Ming Kan, Sze-Chuen (Cesar) Wong
International Journal of Molecular Sciences.2024; 25(16): 8594. CrossRef
Modeling the management of patients with human epidermal growth factor receptor 2-positive breast cancer with liquid biopsy: the future of precision medicine
Eleonora Nicolò, Caterina Gianni, Giuseppe Curigliano, Carolina Reduzzi, Massimo Cristofanilli
Current Opinion in Oncology.2024; 36(6): 503. CrossRef
Current progress in chimeric antigen receptor-modified T cells for the treatment of metastatic breast cancer
Li Yin, Gui-lai Chen, Zhuo Xiang, Yu-lin Liu, Xing-yu Li, Jing-wang Bi, Qiang Wang
Biomedicine & Pharmacotherapy.2023; 162: 114648. CrossRef
Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer
Kyoungmin Lee, Jongwon Lee, Jungmin Choi, Sung Hoon Sim, Jeong Eun Kim, Min Hwan Kim, Yeon Hee Park, Jee Hyun Kim, Su-Jin Koh, Kyong Hwa Park, Myoung Joo Kang, Mi Sun Ahn, Kyoung Eun Lee, Hee-Jun Kim, Hee Kyung Ahn, Han Jo Kim, Keon Uk Park, In Hae Park
Scientific Reports.2023;[Epub] CrossRef
Association of PIK3CA mutation with outcomes in HER2-positive breast cancer treated with anti-HER2 therapy: A meta-analysis and bioinformatic analysis of TCGA‑BRCA data
Haizhu Chen, Xingbin Hu, Daquan Wang, Ying Wang, Yunfang Yu, Herui Yao
Translational Oncology.2023; 37: 101738. CrossRef
Appraisal of Systemic Treatment Strategies in Early HER2-Positive Breast Cancer—A Literature Review
Danilo Giffoni de Mello Morais Mata, Rania Chehade, Malek B. Hannouf, Jacques Raphael, Phillip Blanchette, Abdullah Al-Humiqani, Monali Ray
Cancers.2023; 15(17): 4336. CrossRef
The clinical significance of HER2 expression in DCIS
Ioanna Akrida, Francesk Mulita
Medical Oncology.2022;[Epub] CrossRef

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307 Download
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12 Crossref

Hematologic malignancy

Predictive Parameters of Febrile Neutropenia and Clinical Significance of G-CSF Receptor Signaling Pathway in the Development of Neutropenia during R-CHOP Chemotherapy with Prophylactic Pegfilgrastim in Patients with Diffuse Large B-Cell Lymphoma: Do Young Kim, Jehyun Nam, Joo-Seop Chung, Byeol Eun Jeon, Ji Hyun Lee, Jae-Cheol Jo, Sang-Woo Kim, Ho-Jin Shin; Cancer Res Treat. 2022;54(4):1256-1267. Published online December 31, 2021; DOI: https://doi.org/10.4143/crt.2021.944

Abstract PDF Supplementary Material PubReader ePub

Purpose
Pegfilgrastim is widely used to prevent chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) in patients with diffuse large B-cell lymphoma (DLBCL). We investigated the predictive factors affecting CIN and FN incidence in patients with DLBCL receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy with pegfilgrastim and conducted experiments to find reason for the occurrence of CIN even when pegfilgrastim was used.
Materials and Methods
We reviewed the CIN and FN events of 200 patients with DLBCL. Based on these data, we investigate the association with predictive factor and the levels of granulocyte-colony stimulating factor (G-CSF) receptor signaling pathway markers (pSTAT3, pAKT, pERK1/2, pBAD, and CXCR4) in bone marrow (BM) samples isolated from patients with DLBCL.
Results
FN was significantly associated with stage III/IV (hazard ratio [HR], 12.74) and low serum albumin levels (HR, 3.87). Additionally, patients with FN had lower progression-free survival (PFS; 2-year PFS, 51.1 % vs. 74.0%) and overall survival (OS; 2-year OS, 58.2% vs. 85.0%) compared to those without FN. The occurrence of CIN was associated with overexpression of G-CSF receptor signaling pathway markers, and expression levels of these markers were upregulated in BM cells co-cultured with DLBCL cells. The rate of neutrophil apoptosis was also higher in neutrophils co-cultured with DLBCL cells and was further promoted by treatment with doxorubicin.
Conclusion
Our findings suggest that high DLBCL burden may alter the BM environment and G-CSF receptor signaling pathway, even in chemotherapy-naïve state, which may increase CIN frequency during R-CHOP chemotherapy.

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Hypogammaglobulinemia at Diagnosis is Associated With Inferior Survival and Higher Risk of Infections in Diffuse Large B Cell Lymphoma
Åsa Lindberg, Åsa Johansson, Fredrik Kahn, Göran Jönsson, Mats Jerkeman
Hematological Oncology.2025;[Epub] CrossRef
Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study
Masaya Morimoto, Yuma Yokoya, Kikuaki Yoshida, Hideki Kosako, Yoshikazu Hori, Toshiki Mushino, Shinobu Tamura, Reiko Ito, Ryosuke Koyamada, Takuya Yamashita, Shinichiro Mori, Nobuyoshi Mori, Sachiko Ohde
Hematology Reports.2024; 16(1): 76. CrossRef
Multi‐omics integration reveals the oncogenic role of eccDNAs in diffuse large B‐cell lymphoma through STING signalling
Zijuan Wu, Wei Zhang, Luqiao Wang, Jiayan Leng, Yongle Li, Zhou Fan, Mengtao Zhan, Lei Cao, Yongning Jiang, Yan Jiang, Bing Sun, Jianxin Fu, Jianyong Li, Wenyu Shi, Hui Jin
Clinical and Translational Medicine.2024;[Epub] CrossRef
Transcriptomic analysis of neutrophil apoptosis induced by diffuse large B-cell lymphoma unveils a potential role in neutropenia
Byeol-Eun Jeon, Ji-Eun Lee, Jungwook Park, Hyejung Jung, Eun Gyung Park, Du Hyeong Lee, Young-Su Seo, Heui-Soo Kim, Ho-Jin Shin, Sang-Woo Kim
Genes & Genomics.2023; 45(8): 1013. CrossRef

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Lung Cancer

Risk of Coronavirus Disease 2019 Occurrence, Severe Presentation, and Mortality in Patients with Lung Cancer: Bumhee Yang, Hayoung Choi, Sun-Kyung Lee, Sung Jun Chung, Yoomi Yeo, Yoon Mi Shin, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Yun Su Sim, Ho Joo Yoon, Jang Won Sohn, Hyun Lee, Sang-Heon Kim; Cancer Res Treat. 2021;53(3):678-684. Published online December 28, 2020; DOI: https://doi.org/10.4143/crt.2020.1242

Abstract PDF PubReader ePub

Purpose
This study aimed to analyze whether patients with lung cancer have a higher susceptibility of coronavirus disease 2019 (COVID-19), severe presentation, and higher mortality than those without lung cancer.
Materials and Methods
A nationwide cohort of confirmed COVID-19 (n=8,070) between January 1, 2020, and May 30, 2020, and a 1:15 age-, sex-, and residence-matched cohort (n=121,050) were constructed. A nested case-control study was performed to compare the proportion of patients with lung cancer between the COVID-19 cohort and the matched cohort.
Results
The proportion of patients with lung cancer was significantly higher in the COVID-19 cohort (0.5% [37/8,070]) than in the matched cohort (0.3% [325/121,050]) (p=0.002). The adjusted odds ratio [OR] of having lung cancer was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR, 1.51; 95% confidence interval [CI], 1.05 to 2.10). Among patients in the COVID-19 cohort, compared to patients without lung cancer, those with lung cancer were more likely to have severe COVID-19 (54.1% vs. 13.2%, p < 0.001), including mortality (18.9% vs. 2.8%, p < 0.001). The adjusted OR for the occurrence of severe COVID-19 in patients with lung cancer relative to those without lung cancer was 2.24 (95% CI, 1.08 to 4.74).
Conclusion
The risk of COVID-19 occurrence and severe presentation, including mortality, may be higher in patients with lung cancer than in those without lung cancer.

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Impact of physical activity on all-cause mortality in individuals with non-cystic fibrosis bronchiectasis
Sang Hyuk Kim, Hayoung Choi, Kyungdo Han, Jin-Hyung Jung, Bumhee Yang, Hyun Lee
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Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study
Bo-Guen Kim, Hyun Lee, Yeonghee Eun, Kyungdo Han, Jin-Hyung Jung, Hayoung Choi, Hyungjin Kim, Dong Wook Shin
Scientific Reports.2025;[Epub] CrossRef
COVID-19 and risk of long-term mortality in COPD: a nationwide population-based cohort study
Hyun Lee, Sang Hyuk Kim, Cho Yun Jeong, Jee-Eun Chung, Youlim Kim, Kyung Hoon Min, Kwang Ha Yoo, Jong Seung Kim, Ji-Yong Moon
BMJ Open Respiratory Research.2025; 12(1): e002694. CrossRef
Comprehensive risk assessment for pulmonary manifestations in systemic lupus erythematosus: a large-scale Korean population-based longitudinal study
Bo-Guen Kim, Jiyeong Kim, Yeonghee Eun, Dong Won Park, Sang-Heon Kim, Hyun Lee
RMD Open.2025; 11(1): e005267. CrossRef
Risk of acute exacerbation of chronic obstructive pulmonary disease after COVID-19 recovery: a nationwide population-based cohort study
Sang Hyuk Kim, Hyun Lee, Min Ji Kim, Youlim Kim, Kyung Hoon Min, Kwang Ha Yoo, Jong Seung Kim, Ji-Yong Moon
Respiratory Research.2025;[Epub] CrossRef
Increased risk of suicide among individuals with chronic obstructive pulmonary disease: A nationwide cohort study in Korea
Sang Hyuk Kim, Ji-Yong Moon, Taehee Kim, Jin-Hyung Jung, Kyungdo Han, Kyung Hoon Min, Hyun Lee
Journal of Affective Disorders.2025; 381: 507. CrossRef
Increased Risk of New-Onset Asthma After COVID-19: A Nationwide Population-Based Cohort Study
Bo-Guen Kim, Hyun Lee, Sang Woo Yeom, Cho Yun Jeong, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Jong Seung Kim, Sang-Heon Kim
The Journal of Allergy and Clinical Immunology: In Practice.2024; 12(1): 120. CrossRef
Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: a nationwide population-based cohort study
Bo-Guen Kim, Hyun Lee, Cho Yun Jeong, Sang Woo Yeom, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Jong Seung Kim, Sang-Heon Kim
Frontiers in Public Health.2024;[Epub] CrossRef
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Yuxian Chen, Yang Li, Hong Meng, Chunhai Li, Fanlei Kong
Frontiers in Oncology.2024;[Epub] CrossRef
A year of experience with COVID‐19 in patients with cancer: A nationwide study
Mina Khosravifar, Sogol Koolaji, Negar Rezaei, Ali Ghanbari, Seyedeh Melika Hashemi, Erfan Ghasemi, Ali Bitaraf, Ozra Tabatabaei‐Malazy, Nazila Rezaei, Sahar Mohammadi Fateh, Arezou Dilmaghani‐Marand, Rosa Haghshenas, Ameneh Kazemi, Erfan Pakatchian, Farz
Cancer Reports.2023;[Epub] CrossRef
Risk factors for mortality among lung cancer patients with covid-19 infection: A systematic review and meta-analysis
Mingyue Wu, Siru Liu, Changyu Wang, Yuxuan Wu, Jialin Liu, Yoon-Seok Chung
PLOS ONE.2023; 18(9): e0291178. CrossRef
International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical Trials
Matthew P. Smeltzer, Giorgio V. Scagliotti, Heather A. Wakelee, Tetsuya Mitsudomi, Upal Basu Roy, Russell C. Clark, Renee Arndt, Clayton D. Pruett, Karen L. Kelly, Peter Ujhazy, Melissa L. Johnson, Yesim Eralp, Carlos H. Barrios, Fabrice Barlesi, Fred R.
Journal of Thoracic Oncology.2022; 17(5): 651. CrossRef
Conceptual Framework for Cancer Care During a Pandemic Incorporating Evidence From the COVID-19 Pandemic
Vivienne Milch, Anne E. Nelson, Melissa Austen, Debra Hector, Scott Turnbull, Rahul Sathiaraj, Carolyn Der Vartanian, Rhona Wang, Cleola Anderiesz, Dorothy Keefe
JCO Global Oncology.2022;[Epub] CrossRef
COVID-19 and Lung Cancer Survival: An Updated Systematic Review and Meta-Analysis
Simone Oldani, Fausto Petrelli, Giuseppina Dognini, Karen Borgonovo, Maria Chiara Parati, Mara Ghilardi, Lorenzo Dottorini, Mary Cabiddu, Andrea Luciani
Cancers.2022; 14(22): 5706. CrossRef
Interstitial lung disease increases susceptibility to and severity of COVID-19
Hyun Lee, Hayoung Choi, Bumhee Yang, Sun-Kyung Lee, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
European Respiratory Journal.2021; 58(6): 2004125. CrossRef
Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis
Marco Tagliamento, Elisa Agostinetto, Marco Bruzzone, Marcello Ceppi, Kamal S. Saini, Evandro de Azambuja, Kevin Punie, C. Benedikt Westphalen, Gilberto Morgan, Paolo Pronzato, Lucia Del Mastro, Francesca Poggio, Matteo Lambertini
Critical Reviews in Oncology/Hematology.2021; 163: 103365. CrossRef
Characteristics and outcomes of the Korean patients with coronavirus disease 2019; analyses of the national database
Sang-Heon Kim
Allergy, Asthma & Respiratory Disease.2021; 9(3): 113. CrossRef

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Lung cancer

Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase–Low Squamous Cell Lung Cancer: Mihong Choi, Heung Tae Kim, Ji-Youn Han, Geon Kook Lee, Soo-Hyun Lee, Kun Young Lim, Jungnam Joo, Hye Jin Won, Jin Soo Lee, Youngjoo Lee; Cancer Res Treat. 2021;53(1):87-92. Published online August 13, 2020; DOI: https://doi.org/10.4143/crt.2020.741

Abstract PDF Supplementary Material PubReader ePub

Purpose
Squamous cell carcinomas (SqCC) of the lung often express high levels of thymidylate synthase (TS), which is associated with primary resistance to pemetrexed. We explored the efficacy of pemetrexed in a selected population of patients with lung SqCC with low TS expression.
Materials and Methods
In this single-arm phase II trial, we enrolled 32 previously-treated patients with advanced lung SqCC exhibiting low immunohistochemical staining for TS (i.e., in 10% or less of tumor cells). The primary endpoint was 12-week progression-free survival (PFS) rate.
Results
Of 32 patients, eight patients (25%) had an Eastern Cooperative Oncology Group performance status of 2, and seven patients (22%) had previously received three or more lines of chemotherapy. The disease control rate from pemetrexed treatment was 30%, and no objective response was observed. The 12-week PFS rate was 24.5% (95% confidence interval [CI], 13.0 to 46.1). Median PFS was 1.3 months (95% CI, 1.3 to 2.7), and median overall survival was 11.8 months (95% CI, 8.1 to not applicable). Most of adverse events were grade 1 or 2.
Conclusion
Pemetrexed demonstrated modest activity as a salvage chemotherapy in patients with advanced lung SqCC with low TS expression, although its toxicity was generally manageable.

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Bioengineered miR-7-5p modulates non–small cell lung cancer cell metabolism to improve therapy
Gavin M. Traber, Mei-Juan Tu, Su Guan, Neelu Batra, Ai-Ming Yu
Molecular Pharmacology.2025; 107(1): 100006. CrossRef

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Genitourinary cancer

Cause of Mortality after Radical Prostatectomy and the Impact of Comorbidity in Men with Prostate Cancer: A Multi-institutional Study in Korea: Sahyun Pak, Dalsan You, In Gab Jeong, Dong-Eun Lee, Sung Han Kim, Jae Young Joung, Kang-Hyun Lee, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn; Cancer Res Treat. 2020;52(4):1242-1250. Published online July 3, 2020; DOI: https://doi.org/10.4143/crt.2020.286

Abstract PDF Supplementary Material PubReader ePub: Purpose
This study aimed to examine the causes of death in Korean patients who underwent radical prostatectomy for prostate cancer and investigate the relationship between comorbidity and mortality.
Materials and Methods
We conducted a retrospective multicenter cohort study including 4,064 consecutive patients who had prostate cancer and underwent radical prostatectomy between January 1998 and June 2013. The primary endpoint of this study was all-cause mortality, and the secondary endpoints were cancer-specific mortality (CSM) and other-cause mortality (OCM). Charlson comorbidity index (CCI) was calculated to assess the comorbidities of each patient.
Results
Of 4,064 patients, 446 (11.0%) died during follow-up. The cause of death was prostate cancer in 132 patients (29.6%), other cancers in 121 patients (27.1%), and vascular disease in 57 patients (12.8%) in our cohort. The overall 10-year CSM rate was lower than the OCM rate (4.6% vs. 10.5%). The 10-year CSM rate was lower than the OCM rate in low- to intermediate-risk group patients (1.2% vs. 10.6%), whereas they were similar in high-risk group patients (11.8% vs. 10.1%). In the multivariable analysis, CCI was independently associated with all-cause mortality after radical prostatectomy, regardless of age and pathologic features.
Conclusion
Death from prostate cancer was rare in Korean men who underwent radical prostatectomy. Clinicians should be aware of the possibility of overtreatment of low-risk prostate cancer in men with significant comorbidity. Our findings may help to facilitate counseling and plan management in this patient group.

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Outcomes of Pregnancy after Breast Cancer in Korean Women: A Large Cohort Study: Moo Hyun Lee, Young Ae Kim, Jin Hyuk Hong, So-Youn Jung, Sunmi Lee, Sun-Young Kong, Boyoung Park, Eun Sook Lee; Cancer Res Treat. 2020;52(2):426-437. Published online September 3, 2019; DOI: https://doi.org/10.4143/crt.2018.382

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to determine the rate and outcomes of pregnancies subsequent to breast cancer in Korea, and the effect of such pregnancies on the prognosis of women who survived breast cancer and subsequently conceived. Materials and Methods We followed a total of 31,761 Korean women 45 years of age or younger who were treated for primary breast cancer from 2002 to 2010. We also included follow-up surveys that were conducted through December 2011. We identified recurrence and mortality from breast cancer using data linked to the Korea National Health Insurance database. We used propensity score matching of the study cohort to analyze the risks of recurrence and mortality from breast cancer depending on pregnancy.
Results
Within our sample, 992 women (3.1%) became pregnant after receiving treatment for breast cancer. Of those, 622 (67.5%) successfully delivered; the remaining 370 (32.5%) failed to deliver. After propensity score matching, we found that the women who became pregnant after breast cancer did not have a different risk of recurrence (hazard ratio [HR], 0.503; 95% confidence interval [CI], 0.434 to 0.584) and death (HR, 0.520; 95% CI, 0.397 to 0.681), compared with those who did not conceive after breast cancer treatment. Conclusion Our study is the first to report outcomes for Korean women who survived breast cancer and subsequently conceived. Women who survived breast cancer and subsequently became pregnant did not show a poorer survival outcome, compared with those who did not become pregnant.

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Reproduction outcomes and prognostic significance of pregnancy after nasopharyngeal carcinoma treatment
Meijuan Luo, Liting Liu, Zhenchong Yang, Yujing Liang, Dongxiang Wen, Sailan Liu, Xiaoyun Li, Chuanmiao Xie, Linquan Tang, Qiuyan Chen, Shanshan Guo, Haiqiang Mai
Annals of Medicine.2025;[Epub] CrossRef
Conception and pregnancy among women with a live birth after breast cancer treatment: A survey study of young breast cancer survivors
Kimia Sorouri, Tal Sella, Shoshana M. Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Ann H. Partridge
Cancer.2024; 130(4): 517. CrossRef
Safe and successful pregnancy following breast cancer treatment in young patients 35 years old or under without invasive fertility preservation: a retrospective study
Ji Hye Kim, Yong Yeup Kim, Jai Hyun Chung, Woo Young Kim, Jae Bok Lee, Sang Uk Woo
Annals of Surgical Treatment and Research.2024; 106(4): 189. CrossRef
Female reproductive health in pediatric, adolescent, and young adult cancer survivors
Holly R. Hoefgen, Janie Benoit, Serena Chan, Yasmin Jayasinghe, Maryam Lustberg, Victoria Pohl, Amanda Saraf, Deb Schmidt, Leslie Coker Appiah
Pediatric Blood & Cancer.2023;[Epub] CrossRef
Pregnancy rate, maternal and neonatal outcomes among breast cancer survivors: A systematic review
Marzieh Azizi, Elham Ebrahimi, Zahra Behboodi Moghadam, Zohreh Shahhosseini, Maryam Modarres
Nursing Open.2023; 10(10): 6690. CrossRef
Breast Cancer in Pregnancy
Natalie Levey, Iris Krishna
Obstetrics and Gynecology Clinics of North America.2022; 49(1): 181. CrossRef
Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group
Soo Youn Bae, Jihyoun Lee, Ji Sung Lee, Jae Sun Yoon, Ku Sang Kim, Yoo Seok Kim, Zisun Kim, Jun Won Min, Eun-Jung Shim, Ilkyun Lee, Min Hyuk Lee, Sungmin Park
The Breast.2022; 63: 46. CrossRef
Update on Pregnancy Following Breast Cancer Diagnosis and Treatment
Marta Perachino, Francesca Poggio, Luca Arecco, Eva Blondeaux, Stefano Spinaci, Camilla Marrocco, Alessia Levaggi, Matteo Lambertini
The Cancer Journal.2022; 28(3): 176. CrossRef
Survival outcomes following pregnancy or assisted reproductive technologies after breast cancer: A population‐based study
J. Alejandro Rauh‐Hain, Jose Zubizarreta, Roni Nitecki, Alexander Melamed, Shuangshuang Fu, Kirsten Jorgensen, Paula C. Brady, Valerie L. Baker, Mariana Chavez‐MacGregor, Sharon H. Giordano, Nancy L. Keating
Cancer.2022; 128(17): 3243. CrossRef
Survival after breast cancer in women with a subsequent live birth: Influence of age at diagnosis and interval to subsequent pregnancy
Richard A. Anderson, Matteo Lambertini, Peter S. Hall, W. Hamish Wallace, David S. Morrison, Tom W. Kelsey
European Journal of Cancer.2022; 173: 113. CrossRef
Pregnancy After Breast Cancer: A Systematic Review and Meta-Analysis
Matteo Lambertini, Eva Blondeaux, Marco Bruzzone, Marta Perachino, Richard A. Anderson, Evandro de Azambuja, Philip D. Poorvu, Hee Jeong Kim, Cynthia Villarreal-Garza, Barbara Pistilli, Ines Vaz-Luis, Cristina Saura, Kathryn J. Ruddy, Maria Alice Franzoi,
Journal of Clinical Oncology.2021; 39(29): 3293. CrossRef

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Identification of Significant Prognostic Tissue Markers Associated with Survival in Upper Urinary Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy: A Retrospective Immunohistochemical Analysis Using Tissue Microarray: Sung Han Kim, Weon Seo Park, Boram Park, Jinsoo Chung, Jae Young Joung, Kang Hyun Lee, Ho Kyung Seo; Cancer Res Treat. 2020;52(1):128-138. Published online June 19, 2019; DOI: https://doi.org/10.4143/crt.2019.119

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to identify prognostic tissue markers for several survival outcomes after radical nephroureterectomy among patients with upper urinary tract urothelial carcinoma using tissue microarray and immunohistochemistry.
Materials and Methods
Retrospectively, data of 162 non-metastatic patients with upper urinary tract urothelial carcinoma after radical nephroureterectomy between 2004 and 2016 were reviewed to determine intravesical recurrence-free survival (IVRFS), disease-free survival (DFS), and overall survival (OS). The expression of 27 tissue markers on a tissue microarray of radical nephroureterectomy samples and prognostic values of clinicopathological parameters were evaluated using immunohistochemistry and Cox proportional hazard models after adjusting for significant prognostic clinicopathological variables. The expression of all tissue markers was categorized into a binary group with continuous H-scores (0-300).
Results
Median follow-up was 53.4 months (range, 3.6 to 176.5 months); and, 58 (35.8%), 48 (29.6%), and 19 (11.7%) bladder recurrence, disease progression, and all cause death, respectively, were identified. After adjusting for significant clinicopathological factors including intravesical instillation for bladder recurrence-free survival, pathologic T category and intravesical instillation for disease progression-free survival , and pathologic T category for OS (p < 0.05), IVRFS was associated with epithelial cadherin (hazard ratio [HR], 0.49), epidermal growth factor receptor/erythroblastosis oncogene B (c-erb) (HR, 2.59), and retinoblastoma protein loss (HR, 1.85); DFS was associated with cyclin D1 (HR, 2.16) and high-molecular-weight cytokeratin (HR, 0.42); OS was associated with E-cadherin (HR, 0.34) and programmed cell death 1 ligand (HR, 13.42) (p < 0.05).
Conclusion
Several significant tissue markers were associated with survival outcomes in upper urinary tract urothelial carcinoma patients treated with radical nephroureterectomy.

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A multi‐institutional retrospective study of open versus laparoscopic nephroureterectomy focused on the intravesical recurrence
Soichiro Shimura, Kazumasa Matsumoto, Masaomi Ikeda, Shigenori Moroo, Dai Koguchi, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
Asia-Pacific Journal of Clinical Oncology.2023; 19(1): 71. CrossRef
Upper Tract Urinary Carcinoma: A Unique Immuno-Molecular Entity and a Clinical Challenge in the Current Therapeutic Scenario
Giulia Mazzaschi, Giulia Claire Giudice, Matilde Corianò, Davide Campobasso, Fabiana Perrone, Michele Maffezzoli, Irene Testi, Luca Isella, Umberto Maestroni, Sebastiano Buti
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
Prognostic value of programmed death ligand‐1 and programmed death‐1 expression in patients with upper tract urothelial carcinoma
Luca Campedel, Eva Compérat, Géraldine Cancel‐Tassin, Justine Varinot, Christian Pfister, Clara Delcourt, Françoise Gobet, Mathieu Roumiguié, Pierre‐Marie Patard, Gwendoline Daniel, Pierre Bigot, Julie Carrouget, Caroline Eymerit, Stéphane Larré, Priscill
BJU International.2023; 132(5): 581. CrossRef
The Prevalence and Prognostic Role of PD-L1 in Upper Tract Urothelial Carcinoma Patients Underwent Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
Yi Lu, Jiaqi Kang, Zhiwen Luo, Yuxuan Song, Jia Tian, Zhongjia Li, Xiao Wang, Li Liu, Yongjiao Yang, Xiaoqiang Liu
Frontiers in Oncology.2020;[Epub] CrossRef

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Surveillance Rate and its Impact on Survival of Hepatocellular Carcinoma Patients in South Korea: A Cohort Study: Sanghyuk Im, Eun Sun Jang, Ju Hyun Lee, Chung Seop Lee, Beom Hee Kim, Jung Wha Chung, Jin-Wook Kim, Sook-Hyang Jeong; Cancer Res Treat. 2019;51(4):1357-1369. Published online February 12, 2019; DOI: https://doi.org/10.4143/crt.2018.430

Abstract PDF Supplementary Material PubReader ePub

Purpose
Though regular surveillance of hepatocellular carcinoma (HCC) for high-risk patients is widely recommended, its rate and effectiveness are not clear. The aim of this study is to investigate the actual rate of HCC surveillance and its related factors and to clarify its impact on survival in a Korean HCC cohort.
Materials and Methods
From 2012 to 2015, 319 newly diagnosed HCC patients were prospectively enrolled at a tertiary hospital. Patient interviews based on a structured questionnaire survey were conducted. Surveillance was defined as liver imaging test ≥ 2 times with at least 3-month interval within 2 years prior to HCC diagnosis.
Results
Surveillance rate was 39.8%. Of the HCC patients with high-risk factors, only 182 (57.1%) had knowledge for the need for regular surveillance, and 141 (44.2%) had the accurate information about the method (ultrasound-based study). Surveillance group showed a higher proportion of early HCC (p < 0.001) and a longer overall survival (p < 0.001) compared to non-surveillance group. The multivariable Cox regression analysis indicated Child-Pugh class A, history of anti-viral therapy, low serum α-fetoprotein level, non-advanced Barcelona Clinic Liver Cancer stage as independent predictors of overall survival, while regular surveillance was not (p=0.436).
Conclusion
Less than half of the newly diagnosed Korean HCC patients were under surveillance and the accurate perception for the need of HCC surveillance was insufficient. Of those under surveillance, most patients were diagnosed with early stage HCC, which led to the improved survival. Comprehensive efforts to optimize the surveillance program for the target population are warranted.

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Mayur Brahmania, Stephen Congly, Yashasavi Sachar, Kelly W. Burak, Brendan Lethebe, Jessie Hart Szostakiwskyj, David Lautner, Alexandra Medellin, Deepak Bhayana, Jason Wong, Henry Nguyen, Matthew D. Sadler, Meredith Borman, Alexander I. Aspinall, Carla S.
Liver International.2025;[Epub] CrossRef
Impact of Screening on Mortality for Patients Diagnosed with Hepatocellular Carcinoma in a Safety-Net Healthcare System: An Opportunity for Addressing Disparities
Kalyani Narra, Madison Hull, Kari J. Teigen, Vedaamrutha Reddy, Jolonda C. Bullock, Riyaz Basha, Nadia Alawi-Kakomanolis, David E. Gerber, Timothy J. Brown
Cancers.2024; 16(22): 3829. CrossRef
Benefits and harms of screening for hepatocellular carcinoma in high-risk populations: systematic review and meta-analysis
Jichun Yang, Zhirong Yang, Xueyang Zeng, Shuqing Yu, Le Gao, Yu Jiang, Feng Sun
Journal of the National Cancer Center.2023; 3(3): 175. CrossRef
Factors associated with the survival outcomes of patients with untreated hepatocellular carcinoma: An analysis of nationwide data
Min Jung Kwon, Soy Chang, Ji Hoon Kim, Ji Won Han, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Pil Soo Sung
Frontiers in Oncology.2023;[Epub] CrossRef
Prognosis of hepatocellular carcinoma patients diagnosed under regular surveillance: potential implications for surveillance goal
Joo Hye Song, Myung Ji Goh, Yewan Park, Joo Hyun Oh, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Scandinavian Journal of Gastroenterology.2021; 56(3): 274. CrossRef
Prior antiviral treatment and mortality among patients with hepatitis C virus-related hepatocellular carcinoma: A national cohort study
Dong Hyun Sinn, Danbee Kang, Yun Soo Hong, Kwang Cheol Koh, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak, Luca Rinaldi
PLOS ONE.2021; 16(8): e0255624. CrossRef

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Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer: Lan Ying Li, Hee Jung Kim, Sun Ae Park, So Hyun Lee, Lee Kyung Kim, Jung Yun Lee, Sunghoon Kim, Young Tae Kim, Sang Wun Kim, Eun Ji Nam; Cancer Res Treat. 2019;51(3):1117-1127. Published online November 6, 2018; DOI: https://doi.org/10.4143/crt.2018.405

Abstract PDF Supplementary Material PubReader ePub

Purpose
Recurrence and chemoresistance (CR) are the leading causes of death in patients with high-grade serous carcinoma (HGSC) of the ovary. The aim of this study was to identify genetic changes associated with CR mechanisms using a patient-derived xenograft (PDX) mouse model and genetic sequencing.
Materials and Methods
To generate a CR HGSC PDX tumor, mice bearing subcutaneously implanted HGSC PDX tumors were treated with paclitaxel and carboplatin. We compared gene expression and mutations between chemosensitive (CS) and CR PDX tumors with whole exome and RNA sequencing and selected candidate genes. Correlations between candidate gene expression and clinicopathological variables were explored using the Cancer Genome Atlas (TCGA) database and the Human Protein Atlas (THPA).
Results
Three CR and four CS HGSC PDX tumor models were successfully established. RNA sequencing analysis of the PDX tumors revealed that 146 genes were significantly up-regulated and 54 genes down-regulated in the CR group compared with the CS group. Whole exome sequencing analysis showed 39 mutation sites were identified which only occurred in CR group. Differential expression of SAP25, HLA-DPA1, AKT3, and PIK3R5 genes and mutation of TMEM205 and POLR2A may have important functions in the progression of ovarian cancer chemoresistance. According to TCGA data analysis, patients with high HLA-DPA1 expression were more resistant to initial chemotherapy (p=0.030; odds ratio, 1.845).
Conclusion
We successfully established CR ovarian cancer PDX mouse models. PDX-based genetic profiling study could be used to select some candidate genes that could be targeted to overcome chemoresistance of ovarian cancer.

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Retrospective Study of the Significant Predictive Role of Inflammatory Degree in Initial and Repeat Prostate Biopsy Specimens for Detecting Prostate Cancer: Sung Han Kim, Boram Park, Jae Young Joung, Jinsoo Chung, Ho Kyung Seo, Kang Hyun Lee, Weon Seo Park; Cancer Res Treat. 2019;51(3):910-918. Published online October 2, 2018; DOI: https://doi.org/10.4143/crt.2018.314

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to determine whether histologic inflammation (HI) in initial and repeat prostate biopsy specimens was significantly associated with the detection of prostate cancer.
Materials and Methods
Between 2005 and 2017, the clinicopathological records of patients with high prostatespecific antigen (PSA) levels who underwent initial and repeat prostate biopsies were retrospectively reviewed. The presence of HI and its degree in each biopsied specimen were interpreted by one uropathologist with 20 years of experience. The association between HI and cancer diagnosis was statistically assessed, with p < 0.05 considered significant, and the cancer and non-cancer groups were compared.
Results
Among the 522 patients with a median PSA levels of 6.5 ng/dL, including 258 (49.4%) whose cancer was diagnosed following repeat biopsy, the median degrees of HI in the initial and repeat biopsies were 25.0% and 41.7%, respectively. Furthermore, 211 (40.4%) and 247 (47.3%) patients had HI (> 0%) on biopsied specimens, respectively. Comparison of the cancer and noncancer groups revealed that a greater rate of HI specimens in the initial biopsy was associated with fewer prostate cancer diagnoses following repeat biopsy (p < 0.001). Other comparisons between the cancer and non-cancer groups showed that the cancer group had a significantly higher rate of hypertension, whereas those non-cancer group had a significantly higher rate of benign prostatic hyperplasia and prostatitis (p < 0.05).
Conclusion
A finding of a lesser degree of HI in the initial and a greater degree of HI in the repeat biopsied specimens was associated with the higher probability of cancer diagnosis in patients with high PSA levels.

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Growth and differentiation factor 15 and NF‐κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detection
Benjamin A. Rybicki, Sudha M. Sadasivan, Yalei Chen, Oleksandr Kravtsov, Watchareepohn Palangmonthip, Kanika Arora, Nilesh S. Gupta, Sean Williamson, Kevin Bobbitt, Dhananjay A. Chitale, Deliang Tang, Andrew G. Rundle, Kenneth A. Iczkowski
Cancer Medicine.2021; 10(9): 3013. CrossRef

6,435 View
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1 Web of Science
1 Crossref

NFATC3–PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines: Jee-Eun Jang, Hwang-Phill Kim, Sae-Won Han, Hoon Jang, Si-Hyun Lee, Sang-Hyun Song, Duhee Bang, Tae-You Kim; Cancer Res Treat. 2019;51(1):391-401. Published online June 14, 2018; DOI: https://doi.org/10.4143/crt.2018.103

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study was designed to identify novel fusion transcripts (FTs) and their functional significance in colorectal cancer (CRC) lines.
Materials and Methods
We performed paired-end RNA sequencing of 28 CRC cell lines. FT candidates were identified using TopHat-fusion, ChimeraScan, and FusionMap tools and further experimental validation was conducted through reverse transcription-polymerase chain reaction and Sanger sequencing. FT was depleted in human CRC line and the effects on cell proliferation, cell migration, and cell invasion were analyzed.
Results
One thousand three hundred eighty FT candidates were detected through bioinformatics filtering. We selected six candidate FTs, including four inter-chromosomal and two intrachromosomal FTs and each FT was found in at least one of the 28 cell lines. Moreover, when we tested 19 pairs of CRC tumor and adjacent normal tissue samples, NFATC3–PLA2G15 FT was found in two. Knockdown of NFATC3–PLA2G15 using siRNA reduced mRNA expression of epithelial–mesenchymal transition (EMT) markers such as vimentin, twist, and fibronectin and increased mesenchymal–epithelial transition markers of E-cadherin, claudin-1, and FOXC2 in colo-320 cell line harboring NFATC3–PLA2G15 FT. The NFATC3–PLA2G15 knockdown also inhibited invasion, colony formation capacity, and cell proliferation.
Conclusion
These results suggest that that NFATC3–PLA2G15 FTs may contribute to tumor progression by enhancing invasion by EMT and proliferation.

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Deeksha Rikhari, Ankit Srivastava, Sandhya Rai, Mubashra, Srinivas Patnaik, Sameer Srivastava
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Mohadese Mozafari, Siti Nurnasihah Md Hashim, Khairul Bariah Ahmad Amin Noordin, Siti Aishah Zainal, Ahmad Azlina
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N. E. Arnotskaya, T. I. Kushnir, I. A. Kudryavtsev, A. A. Mitrofanov, A. Kh. Bekyashev, V. E. Shevchenko
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Charbel Akkawi, Jerome Feuillard, Felipe Leon Diaz, Khalid Belkhir, Nelly Godefroy, Jean-Marie Peloponese, Marylene Mougel, Sebastien Laine
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Unearthing novel fusions as therapeutic targets in solid tumors using targeted RNA sequencing
Sungbin An, Hyun Hee Koh, Eun Sol Chang, Juyoung Choi, Ji-Young Song, Mi-Sook Lee, Yoon-La Choi
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Ihsan Ullah, Le Yang, Feng-Ting Yin, Ye Sun, Xing-Hua Li, Jing Li, Xi-Jun Wang
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Transcriptome Analysis Reveals MFGE8-HAPLN3 Fusion as a Novel Biomarker in Triple-Negative Breast Cancer
Meng-Yuan Wang, Man Huang, Chao-Yi Wang, Xiao-Ying Tang, Jian-Gen Wang, Yong-De Yang, Xin Xiong, Chao-Wei Gao
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Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes
Davide Maspero, Alice Dassano, Giulia Pintarelli, Sara Noci, Loris De Cecco, Matteo Incarbone, Davide Tosi, Luigi Santambrogio, Tommaso A Dragani, Francesca Colombo
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Yan Lin, Moussa Harouna Koumba, Suxuan Qu, Dongxu Wang, Lianjie Lin
Cellular Signalling.2020; 74: 109707. CrossRef
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Nishu Dalal, Rekha Jalandra, Minakshi Sharma, Hridayesh Prakash, Govind K. Makharia, Pratima R. Solanki, Rajeev Singh, Anil Kumar
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Vincenza Barresi, Ilaria Cosentini, Chiara Scuderi, Salvatore Napoli, Virginia Di Bella, Giorgia Spampinato, Daniele Filippo Condorelli
International Journal of Molecular Sciences.2019; 20(21): 5252. CrossRef
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Filippo Pagani, Giovanni Randon, Vincenzo Guarini, Alessandra Raimondi, Michele Prisciandaro, Riccardo Lobefaro, Maria Di Bartolomeo, Gabriella Sozzi, Filippo de Braud, Patrizia Gasparini, Filippo Pietrantonio
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Psychosocial Health of Disease-Free Breast Cancer Survivors Compared with Matched Non-cancer Controls: Boyoung Park, Moo Hyun Lee, Sun-Young Kong, Eun Sook Lee; Cancer Res Treat. 2019;51(1):178-186. Published online April 5, 2018; DOI: https://doi.org/10.4143/crt.2017.585

Abstract PDF PubReader ePub

Purpose
The present study investigated the psychosocial health of disease-free breast cancer survivors who receive health examinations compared to matched non-cancer controls in a community setting.
Materials and Methods
We used baseline data from the Health Examinee cohort, which is composed of subjects participating in health. The disease-free breast cancer survivors were defined as those who were ≥ 2 years from initial diagnosis of breast cancer who had completed treatment. Females without a history of cancer were randomly selected at 1:4 ratio by 5-year age groups, education, and household income as a comparison group. We analyzed results from the Psychosocial Well-being Index-Short Form (PWI-SF) as a psychosocial health measurement.
Results
A total of 347 survivors of breast cancer and 1,388 matched controls were included. Total scores on the PWI-SF were lower in breast cancer survivors than matched non-cancer controls (p=0.006), suggesting a lower level of psychosocial stress in breast cancer survivors. In comparison to the control group, prevalence of drinking, smoking and obesity were lower, while exercising for ≥ 150 min/wk was higher in breast cancer survivors (p < 0.05). These findings suggest that breast cancer survivors have better health behaviors than their noncancer controls. After adjusting for other sociodemographic variables, breast cancer survivors were 36% less likely to be included in the stress group (odds ratio, 0.64; 95% confidence interval, 0.42 to 0.98).
Conclusion
The disease-free breast cancer survivors resuming daily life demonstrated better psychosocial health status compared to matched non-cancer controls.

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Effect of perceived injustice-targeted pain neuroscience education compared with biomedically focused education in breast cancer survivors: a study protocol for a multicentre randomised controlled trial (BCS-PI trial)
Eva Roose, Eva Huysmans, Laurence Leysen, Kenza Mostaqim, Paul Van Wilgen, David Beckwée, Marijke De Couck, Annick Timmermans, Rinske Bults, Jo Nijs, Astrid Lahousse
BMJ Open.2024; 14(1): e075779. CrossRef
Effects of a Single Session of Mindfulness and Compassion on Skin Temperature in Breast Cancer Survivors
David A. Rodríguez, Nadia Martínez, Li Erandi Tepepa Flores, Benjamín Domínguez, Patricia Cortés, Ana L. Chávez
International Journal of Environmental Research and Public Health.2024; 21(8): 1064. CrossRef
Gender Difference in the Impact of Total Energy Intake on the Association between Low Fiber Intake and Mental Health in Middle-Aged and Older Adults
Sinyoung Cho, Minseon Park
Nutrients.2024; 16(16): 2583. CrossRef
Psychological factors influencing healthcare utilization in breast cancer survivors with pain
Eva Roose, Wilfried Cools, Laurence Leysen, Paul Van Wilgen, David Beckwée, Annick Timmermans, Rinske Bults, Jo Nijs, Marian Vanhoeij, Christel Fontaine, Astrid Lahousse, Eva Huysmans
Pain Medicine.2024; 25(12): 768. CrossRef
Determinants of Psychosocial Distress in Breast Cancer Patients at a Safety Net Hospital
Jessica K. Liu, Amy H. Kaji, Katherine G. Roth, Danielle M. Hari, James J. Yeh, Christine Dauphine, Junko Ozao-Choy, Kathryn T. Chen
Clinical Breast Cancer.2022; 22(1): 43. CrossRef
Self-Concept and Psychosocial Well-Being among Korean Women with BRCA1/2 Gene Mutations
Kyunghwa Lee, Doo Ree Kim
Asian Oncology Nursing.2022; 22(1): 11. CrossRef
Psychosocial stress accompanied by an unhealthy eating behavior is associated with abdominal obesity in Korean adults: A community-based prospective cohort study
Minji Kim, Yangha Kim
Frontiers in Nutrition.2022;[Epub] CrossRef
Effect of Psychosocial Distress on the Rate of Kidney Function Decline
Jae Young Kim, Young Su Joo, Jong Hyun Jhee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Journal of General Internal Medicine.2021; 36(10): 2966. CrossRef
Signifikanter Überlebensvorteil durch Sacituzumab-Govitecan beim TNBC
Sebastian Weiße, Svenja Quaester, Jürgen Dunst
InFo Hämatologie + Onkologie.2021; 24(9): 29. CrossRef

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Geographical Variations and Trends in Major Cancer Incidences throughout Korea during 1999-2013: Young-Joo Won, Kyu-Won Jung, Chang-Mo Oh, Eun-Hye Park, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-based Regional Cancer Registries; Cancer Res Treat. 2018;50(4):1281-1293. Published online January 4, 2018; DOI: https://doi.org/10.4143/crt.2017.411

Abstract PDF PubReader ePub

Purpose
We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013.
Materials and Methods
Data were obtained from the Korean National Cancer Incidence Database. We calculated the age-standardized cumulative cancerincidences according to sex and geographicalregion (metropolitan cities, provinces, and districts) for three 5-year periods (1999-2003, 2004- 2008, and 2009-2013). Each quintile interval contained the same number of regions. Disease maps were created to visualize regional differences in the cancer incidences.
Results
Substantial differences in cancer incidences were observed according to district and cancer type. The largest variations between geographical regions were found for thyroid cancer among both men and women. There was little variation in the incidences of stomach, colorectal, and lung cancer according to geographical region. Substantially elevated incidences of specific cancers were observed in Jeollanam-do (thyroid); Daejeon (colorectum); Jeollanam-do, Gyeongsangbuk-do, and Chungcheongbuk-do (lung); Seocho-gu, Gangnam-gu and Seongnam, Bundang-gu (breast and prostate); Chungcheong and Gyeongsang provinces (stomach); Ulleung-gun and the southern districts of Gyeongsangnam-do and Jeollanam-do (liver); and along the Nakdonggang River (gallbladder and biliary tract).
Conclusion
Mapping regional cancer incidences in Korea allowed us to compare the results according to geographical region. Our results may facilitate the development of infrastructure for systematic cancerincidence monitoring,which could promote the planning and implementation of region-specific cancer management programs.

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Role of environmental pollutants-induced ferroptosis in pulmonary diseases
Long Yang, Yongkang Qiao, Zeyu Huang, Yuzhu Chen, Enxi Zhang, Zhiwei Liu, Yuxuan Wang, Shaobo Chen, Jinrui Dong, Bin Liu
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Dagyeong Lee, Hye-won Yun, Nayeon Kim, Juwon Park, Kyu-won Jung, Mina Suh, Dong Wook Shin
Cancer Epidemiology.2024; 91: 102594. CrossRef
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Tung Hoang, Hyeongtaek Woo, Sooyoung Cho, Jeeyoo Lee, Sayada Zartasha Kazmi, Aesun Shin
Cancer Research and Treatment.2023; 55(2): 603. CrossRef
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Cham Thi Nguyen, Insang Song, Inkyung Jung, Yoon‐Jung Choi, Sun‐Young Kim
Cancer Medicine.2023; 12(16): 17418. CrossRef
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Vitor Rodrigues, Rui Martins, Bruno de Sousa
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Regional disparities in major cancer incidence in Korea, 1999-2018
Eun Hye Park, Mee Joo Kang, Kyu-Won Jung, Eun Hye Park, E Hwa Yun, Hye-Jin Kim, Hyun-Joo Kong, Chang Kyun Choi, Jeong-Soo Im, Hong Gwan Seo
Epidemiology and Health.2023; 45: e2023089. CrossRef
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Seon-Ha Kim, Minsu Ock, Min-Woo Jo, Sungchan Park
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Jae-Seok Min, Sang-Ho Jeong, Ji-Ho Park, Taehan Kim, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Miyeong Park, Young-Joon Lee
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Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
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Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
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Family History of Gastric Cancer and Helicobacter pylori Treatment
Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Young-Il Kim, Myeong-Cherl Kook, Boram Park, Jungnam Joo
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Jaehyeong Cho, Seng Chan You, Seongwon Lee, DongSu Park, Bumhee Park, George Hripcsak, Rae Woong Park
International Journal of Environmental Research and Public Health.2020; 17(21): 7824. CrossRef

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Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population: Sung Han Kim, Sohee Kim, Jae Young Joung, Whi-An Kwon, Ho Kyung Seo, Jinsoo Chung, Byung-Ho Nam, Kang Hyun Lee; Cancer Res Treat. 2018;50(4):1194-1202. Published online December 21, 2017; DOI: https://doi.org/10.4143/crt.2017.484

Abstract PDF Supplementary Material PubReader ePub

Purpose
The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model.
Materials and Methods
A total of 1,179,172 Korean men who were cancer free from 1996 to 1997, had taken a physical examination, and completed a lifestyle questionnaire, were enrolled in our study to predict their risk for PC for the next eight years, using the Cox proportional hazards model. The model’s performance was evaluated using the C-statistic and Hosmer‒Lemeshow type chi-square statistics.
Results
The risk prediction model studied age, height, body mass index, glucose levels, family history of cancer, the frequency of meat consumption, alcohol consumption, smoking status, and physical activity, which were all significant risk factors in a univariate analysis. The model performed very well (C statistic, 0.887; 95% confidence interval, 0.879 to 0.895) and estimated an elevated PC risk in patients who did not consume alcohol or smoke, compared to heavy alcohol consumers (hazard ratio [HR], 0.78) and current smokers (HR, 0.73) (p < 0.001).
Conclusion
This model can be used for identifying Korean and other East Asian men who are at a high risk for developing PC, as well as for cancer screening and developing preventive health strategies.

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Okyaz Eminaga, Omran Al-Hamad, Martin Boegemann, Bernhard Breil, Axel Semjonow
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Tailored Biofunctionalized Biosensor for the Label-Free Sensing of Prostate-Specific Antigen
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Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth: Jaehyun Lee, Yong Jae Shin, Kyoungmin Lee, Hee Jin Cho, Jason K. Sa, Sang-Yun Lee, Seok-Hyung Kim, Jeongwu Lee, Yeup Yoon, Do-Hyun Nam; Cancer Res Treat. 2018;50(3):1009-1022. Published online November 10, 2017; DOI: https://doi.org/10.4143/crt.2017.315

Abstract PDF Supplementary Material PubReader ePub

Purpose
Glioblastoma (GBM) is classified as one of the most aggressive and lethal brain tumor. Great strides have been made in understanding the genomic and molecular underpinnings of GBM, which translated into development of new therapeutic approaches to combat such deadly disease. However, there are only few therapeutic agents that can effectively inhibit GBM invasion in a clinical framework. In an effort to address such challenges, we have generated anti-SEMA3A monoclonal antibody as a potential therapeutic antibody against GBM progression.
Materials and Methods
We employed public glioma datasets, Repository of Molecular Brain Neoplasia Data and The Cancer Genome Atlas, to analyze SEMA3AmRNA expression in human GBM specimens. We also evaluated for protein expression level of SEMA3A via tissue microarray (TMA) analysis. Cell migration and proliferation kinetics were assessed in various GBM patient-derived cells (PDCs) and U87-MG cell-line for SEMA3A antibody efficacy. GBM patient-derived xenograft (PDX) models were generated to evaluate tumor inhibitory effect of anti-SEMA3A antibody in vivo.
Results
By combining bioinformatics and TMA analysis, we discovered that SEMA3A is highly expressed in human GBM specimens compared to non-neoplastic tissues. We developed three different anti-SEMA3A antibodies, in fully human IgG form, through screening phage-displayed synthetic antibody library using a classical panning method. Neutralization of SEMA3A significantly reduced migration and proliferation capabilities of PDCs and U87-MG cell line in vitro. In PDX models, treatment with anti-SEMA3A antibody exhibited notable tumor inhibitory effect through down-regulation of cellular proliferative kinetics and tumor-associated macrophages recruitment.
Conclusion
In present study, we demonstrated tumor inhibitory effect of SEMA3A antibody in GBM progression and present its potential relevance as a therapeutic agent in a clinical framework.

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Boric Acid Induces Oxidative Damage and Apoptosis Through SEMA3A/PLXNA1/NRP1 Signalling Pathway in U251 Glioblastoma Cell
Ezgi Kar, Zeynep Övenler, Ceyhan Hacıoğlu, Fatih Kar
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Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes
Natalia Andryszak, Paweł Kurzawa, Monika Krzyżaniak, Marek Ruchała, Michał Nowicki, Dariusz Iżycki, Rafał Czepczyński
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Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization
Ruyu Yang, Fan Yang, Yajing Wei, Biqi Huang, Tiefeng Cao, Hao Tan, Duo Liu, Qiuyu Zou, Jinjuan Wen, Lei Wen, Xi Lu, Changyang Yu, Heng Cai, Xiaofei Xie, Shaoru Jiang, Shuzhong Yao, Yanchun Liang
International Immunopharmacology.2024; 138: 112559. CrossRef
Semaphorins: Novel Insights on Their Emerging Multifaceted Roles in the Evolving Landscape of Breast Cancer
Ts. Popov
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Role of semaphorins, neuropilins and plexins in cancer progression
P. Fernández-Nogueira, P. Linzoain- Agos, M. Cueto-Remacha, I. De la Guia-Lopez, L. Recalde-Percaz, A. Parcerisas, P. Gascon, N. Carbó, A. Gutierrez-Uzquiza, G. Fuster, P. Bragado
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Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance
Radhika Aiyappa-Maudsley, Louis F. V. McLoughlin, Thomas A. Hughes
International Journal of Molecular Sciences.2023; 24(17): 13093. CrossRef
Pinpointing the interaction site between semaphorin‐3A and its inhibitory peptide
Kevin Kretschmer, Jan Stichel, Kathrin Bellmann‐Sickert, Lars Baumann, Donald Bierer, Bernd Riedl, Annette G. Beck‐Sickinger
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Semaphorin 3A influences neuronal processes that are altered in patients with autism spectrum disorder: Potential diagnostic and therapeutic implications
Carmela Matrone, Gabriella Ferretti
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Semaphorins as Potential Immune Therapeutic Targets for Cancer
Jun Jiang, Fang Zhang, Yi Wan, Ke Fang, Ze-dong Yan, Xin-ling Ren, Rui Zhang
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Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
Antonella Lettieri, Roberto Oleari, Alyssa J. J. Paganoni, Cristina Gervasini, Valentina Massa, Alessandro Fantin, Anna Cariboni
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Irina Larionova, Elena Kazakova, Tatiana Gerashchenko, Julia Kzhyshkowska
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Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma
Xiangyu Li, Ming Liu, Junfeng Zhao, Tong Ren, Xin Yan, Lijun Zhang, Xun Wang
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The Prognostic Value of Serum Semaphorin3A and VEGF Levels in Patients with Metastatic Colorectal Cancer
Tuba Karpuz, Murat Araz, Levent Korkmaz, Ibrahim Kılınc, Sidika Findik, Mustafa Karaagaç, Melek Karakurt Eryilmaz, Mehmet Artac
Journal of Gastrointestinal Cancer.2020; 51(2): 491. CrossRef
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Carla Riera-Domingo, Annette Audigé, Sara Granja, Wan-Chen Cheng, Ping-Chih Ho, Fátima Baltazar, Christian Stockmann, Massimiliano Mazzone
Physiological Reviews.2020; 100(1): 1. CrossRef
SEMA3AExon 9 Expression Is a Potential Prognostic Marker of Unfavorable Recurrence-Free Survival in Patients with Tongue Squamous Cell Carcinoma
Tian Tian, Lingnan Zhang, Kailiang Tang, Aiqin Wang, Jing Wang, Jingjing Wang, Fang Wang, Wenlong Wang, Xiangrui Ma
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Sphere-Forming Culture for Expanding Genetically Distinct Patient-Derived Glioma Stem Cells by Cellular Growth Rate Screening
Kayoung Shin, Hyemi Shin, Hee Jin Cho, Hyunju Kang, Jin-Ku Lee, Yun Jee Seo, Yong Jae Shin, Donggeon Kim, Harim Koo, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Hye Won Lee, Do-Hyun Nam
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A comprehensive review of tumor proliferative and suppressive role of semaphorins and therapeutic approaches
Ishtiaque Ahammad
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Christopher A Chuckran, Chang Liu, Tullia C Bruno, Creg J Workman, Dario AA Vignali
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Class-3 Semaphorins and Their Receptors: Potent Multifunctional Modulators of Tumor Progression
Shira Toledano, Inbal Nir-Zvi, Rotem Engelman, Ofra Kessler, Gera Neufeld
International Journal of Molecular Sciences.2019; 20(3): 556. CrossRef
Multifaceted Functional Role of Semaphorins in Glioblastoma
Cristiana Angelucci, Gina Lama, Gigliola Sica
International Journal of Molecular Sciences.2019; 20(9): 2144. CrossRef

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Comparison of Clinical Features and Outcomes in Epithelial Ovarian Cancer according to Tumorigenicity in Patient-Derived Xenograft Models: Kyung Jin Eoh, Young Shin Chung, So Hyun Lee, Sun-Ae Park, Hee Jung Kim, Wookyeom Yang, In Ok Lee, Jung-Yun Lee, Hanbyoul Cho, Doo Byung Chay, Sunghoon Kim, Sang Wun Kim, Jae-Hoon Kim, Young Tae Kim, Eun Ji Nam; Cancer Res Treat. 2018;50(3):956-963. Published online October 17, 2017; DOI: https://doi.org/10.4143/crt.2017.181

Abstract PDF Supplementary Material PubReader ePub

Purpose
Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients.
Materials and Methods
Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity.
Results
Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patientswho underwent non-optimal (residual disease ≥ 1 cm) primary orinterval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers.
Conclusions
Tumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.

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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts
Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong
Scientific Reports.2025;[Epub] CrossRef
TOWARDS Study: Patient-Derived Xenograft Engraftment Predicts Poor Survival in Patients With Newly Diagnosed Triple-Negative Breast Cancer
Christos Vaklavas, Cindy B. Matsen, Zhengtao Chu, Kenneth M. Boucher, Sandra D. Scherer, Satya Pathi, Anna Beck, Kirstyn E. Brownson, Saundra S. Buys, Namita Chittoria, Elyse D'Astous, H. Evin Gulbahce, N. Lynn Henry, Stephen Kimani, Jane Porretta, Regina
JCO Precision Oncology.2024;[Epub] CrossRef
Generation, evolution, interfering factors, applications, and challenges of patient-derived xenograft models in immunodeficient mice
Mingtang Zeng, Zijing Ruan, Jiaxi Tang, Maozhu Liu, Chengji Hu, Ping Fan, Xinhua Dai
Cancer Cell International.2023;[Epub] CrossRef
Cancer “Avatars”: Patient-Derived Xenograft Growth Correlation with Postoperative Recurrence and Survival in Pancreaticobiliary Cancer
Isaac T Lynch, Amro M Abdelrahman, Roberto Alva-Ruiz, Alessandro Fogliati, Rondell P Graham, Rory Smoot, Mark J Truty
Journal of the American College of Surgeons.2023; 237(3): 483. CrossRef
Identification of Prognostic Markers of Gynecologic Cancers Utilizing Patient-Derived Xenograft Mouse Models
Ha-Yeon Shin, Eun-ju Lee, Wookyeom Yang, Hyo Sun Kim, Dawn Chung, Hanbyoul Cho, Jae-Hoon Kim
Cancers.2022; 14(3): 829. CrossRef
Experimental models for ovarian cancer research
Sum In Tsang, Ayon A. Hassan, Sally K.Y. To, Alice S.T. Wong
Experimental Cell Research.2022; 416(1): 113150. CrossRef
Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application
Alessandra Ciucci, Marianna Buttarelli, Anna Fagotti, Giovanni Scambia, Daniela Gallo
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Harnessing preclinical models for the interrogation of ovarian cancer
Tianyu Qin, Junpeng Fan, Funian Lu, Li Zhang, Chen Liu, Qiyue Xiong, Yang Zhao, Gang Chen, Chaoyang Sun
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Prognostic value of patient‐derived xenograft engraftment in pediatric sarcomas
Helena Castillo‐Ecija, Guillem Pascual‐Pasto, Sara Perez‐Jaume, Claudia Resa‐Pares, Monica Vila‐Ubach, Carles Monterrubio, Ana Jimenez‐Cabaco, Merce Baulenas‐Farres, Oscar Muñoz‐Aznar, Noelia Salvador, Maria Cuadrado‐Vilanova, Nagore G Olaciregui, Leire B
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Patient-Derived Xenograft Models in Cervical Cancer: A Systematic Review
Tomohito Tanaka, Ruri Nishie, Shoko Ueda, Shunsuke Miyamoto, Sousuke Hashida, Hiromi Konishi, Shinichi Terada, Yuhei Kogata, Hiroshi Sasaki, Satoshi Tsunetoh, Kohei Taniguchi, Kazumasa Komura, Masahide Ohmichi
International Journal of Molecular Sciences.2021; 22(17): 9369. CrossRef
Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine
Jennifer L. Leiting, Stephen J. Murphy, John R. Bergquist, Matthew C. Hernandez, Tommy Ivanics, Amro M. Abdelrahman, Lin Yang, Isaac Lynch, James B. Smadbeck, Sean P. Cleary, David M. Nagorney, Michael S. Torbenson, Rondell P. Graham, Lewis R. Roberts, Gr
JHEP Reports.2020; 2(2): 100068. CrossRef
Patient-derived xenograft model engraftment predicts poor prognosis after surgery in patients with pancreatic cancer
Qi Chen, Tao Wei, Jianxin Wang, Qi Zhang, Jin Li, Jingying Zhang, Lei Ni, Yi Wang, Xueli Bai, Tingbo Liang
Pancreatology.2020; 20(3): 485. CrossRef
A Biobank of Colorectal Cancer Patient-Derived Xenografts
Suad M. Abdirahman, Michael Christie, Adele Preaudet, Marie C. U. Burstroem, Dmitri Mouradov, Belinda Lee, Oliver M. Sieber, Tracy L. Putoczki
Cancers.2020; 12(9): 2340. CrossRef
High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints
Michael-Antony Lisio, Lili Fu, Alicia Goyeneche, Zu-hua Gao, Carlos Telleria
International Journal of Molecular Sciences.2019; 20(4): 952. CrossRef
Efficient use of patient-derived organoids as a preclinical model for gynecologic tumors
Yoshiaki Maru, Naotake Tanaka, Makiko Itami, Yoshitaka Hippo
Gynecologic Oncology.2019; 154(1): 189. CrossRef
Current Status of Patient-Derived Ovarian Cancer Models
Yoshiaki Maru, Yoshitaka Hippo
Cells.2019; 8(5): 505. CrossRef
Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis
Jianfa Wu, Yunxi Zheng, Qi Tian, Ming Yao, Xiaofang Yi
Journal of Obstetrics and Gynaecology Research.2019; 45(10): 2062. CrossRef
Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells
Ugo Testa, Eleonora Petrucci, Luca Pasquini, Germana Castelli, Elvira Pelosi
Medicines.2018; 5(1): 16. CrossRef

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Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up: Hyae Young Kim, Kyu-Won Jung, Kun Young Lim, Soo-Hyun Lee, Jae Kwan Jun, Jeongseon Kim, Bin Hwangbo, Jin Soo Lee; Cancer Res Treat. 2018;50(3):748-756. Published online July 17, 2017; DOI: https://doi.org/10.4143/crt.2017.312

Abstract PDF Supplementary Material PubReader ePub

Purpose
Because of growing concerns about lung cancer in female never smokers, chest low-dose computed tomography (LDCT) screening is often performed although it has never shown clinical benefits. We examinewhether or not female never smokers really need annual LDCT screening when the initial LDCT showed negative findings.
Materials and Methods
This retrospective cohort study included 4,365 female never smokers aged 40 to 79 years who performed initial LDCT from Aug 2002 to Dec 2007. Lung cancer diagnosis was identified from the Korea Central Cancer Registry Database registered until December 31, 2013. We calculated the incidence, cumulative probability, and standardized incidence ratio (SIR) of lung cancer by Lung Imaging Reporting and Data System (Lung-RADS) categories showed on initial LDCT.
Results
After median follow-up of 9.69 years, 22 (0.5%) had lung cancer. Lung cancer incidence for Lung-RADS category 4 was 1,848.4 (95% confidence interval [CI], 1,132.4 to 3,017.2) per 100,000 person-years and 16.4 (95% CI, 7.4 to 36.4) for categories 1, 2, and 3 combined. The cumulative probability of lung cancer for category 4 was 10.6% at 5 years and 14.8% at 10 years while they were 0.07% and 0.17% when categories 1, 2, and 3 were combined. The SIR for subjects with category 4 was 43.80 (95% CI, 25.03 to 71.14), which was much higher than 0.47 (95% CI, 0.17 to 1.02) for categories 1, 2, and 3 combined.
Conclusion
Considering the low risk of lung cancer development in female never smokers, it seems unnecessary to repeat annual LDCT screening for at least 5 years or even longer unless the initial LDCT showed Lung-RADS category 4 findings.

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Low Dose Computed Tomography for Lung Cancer Screening in Tuberculosis Endemic Countries: A Systematic Review and Meta-Analysis
Vikram Damaraju, Juhu Kiran Krushna Karri, Gayathri Gandrakota, Yamini Marimuthu, Adimulam Ganga Ravindra, Rajeev Aravindakshan, Navneet Singh
Journal of Thoracic Oncology.2025; 20(3): 296. CrossRef
Radiological Changes in Chest Computed Tomography Findings of School Cooks: A Comparative Study With Age-matched Controls
Jung Hee Hong, Jin Young Kim, Kiook Baek
Safety and Health at Work.2025;[Epub] CrossRef
Lung cancer screening for never smokers: current evidence and future directions
Kay Choong See
Singapore Medical Journal.2024;[Epub] CrossRef
Cooking oil fume exposure and Lung-RADS distribution among school cafeteria workers of South Korea
Minjun Kim, Yangho Kim, A Ram Kim, Woon Jung Kwon, Soyeoun Lim, Woojin Kim, Cheolin Yoo
Annals of Occupational and Environmental Medicine.2024;[Epub] CrossRef
Distribution of Solid Lung Nodules Presence and Size by Age and Sex in a Northern European Nonsmoking Population
Jiali Cai, Marleen Vonder, Gert Jan Pelgrim, Mieneke Rook, Gerdien Kramer, Harry J.M. Groen, Geertruida H. de Bock, Rozemarijn Vliegenthart
Radiology.2024;[Epub] CrossRef
Toward More Effective Lung Cancer Risk Stratification to Empower Screening Programs for the Asian Nonsmoking Population
Fu-Zong Wu, Yeun-Chung Chang
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ACR Appropriateness Criteria® Lung Cancer Screening: 2022 Update
Kim L. Sandler, Travis S. Henry, Arya Amini, Saeed Elojeimy, Aine Marie Kelly, Christopher T. Kuzniewski, Elizabeth Lee, Maria D. Martin, Michael F. Morris, Neeraja B. Peterson, Constantine A. Raptis, Gerard A. Silvestri, Arlene Sirajuddin, Betty C. Tong,
Journal of the American College of Radiology.2023; 20(5): S94. CrossRef
Performance of Lung-RADS in different target populations: a systematic review and meta-analysis
Yifei Mao, Jiali Cai, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Matthijs Oudkerk, Marleen Vonder, Monique D. Dorrius, Geertruida H. de Bock
European Radiology.2023; 34(3): 1877. CrossRef
Preoperative computed tomography-guided patent blue localization for pulmonary nodules
Po-Chih Chang, Shah-Hwa Chou, Che-Yu Chuang, I-Hsiao Yang, Yu-Wei Liu, Ming-Cheng Shi, Reu-Sheng Sheu, Ting-Wei Chang
Formosan Journal of Surgery.2022; 55(3): 102. CrossRef
Lung cancer screening in never-smokers: facts and remaining issues
Maurizio V. Infante, Giuseppe Cardillo
European Respiratory Journal.2020; 56(5): 2002949. CrossRef
Low-dose chest computed tomographic screening and invasive diagnosis of pulmonary nodules for lung cancer in never-smokers
Yeon Wook Kim, Hye-Rin Kang, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
European Respiratory Journal.2020; 56(5): 2000177. CrossRef
Predicting Lung Cancer Occurrence in Never-Smoking Females in Asia: TNSF-SQ, a Prediction Model
Li-Hsin Chien, Chung-Hsing Chen, Tzu-Yu Chen, Gee-Chen Chang, Ying-Huang Tsai, Chin-Fu Hsiao, Kuan-Yu Chen, Wu-Chou Su, Wen-Chang Wang, Ming-Shyan Huang, Yuh-Min Chen, Chih-Yi Chen, Sheng-Kai Liang, Chung-Yu Chen, Chih-Liang Wang, Mei-Hsuan Lee, Ren-Hua C
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(2): 452. CrossRef
Role of Low-Dose Computerized Tomography in Lung Cancer Screening among Never-Smokers
Hye-Rin Kang, Jun Yeun Cho, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
Journal of Thoracic Oncology.2019; 14(3): 436. CrossRef
Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018
Haval Balata, Kwun M. Fong, Lizza E. Hendriks, Stephen Lam, Jamie S. Ostroff, Nir Peled, Ning Wu, Charu Aggarwal
Journal of Thoracic Oncology.2019; 14(9): 1513. CrossRef

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Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study: Jae Young Joung, Whi-An Kwon, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won; Cancer Res Treat. 2018;50(1):293-301. Published online April 19, 2017; DOI: https://doi.org/10.4143/crt.2016.543

Abstract PDF Supplementary Material PubReader ePub

Purpose
Secondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC.
Materials and Methods
The study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments.
Results
For patients with primary RCC, the risk of developing a SPC was higher than the risk of developing cancer in the general population (SIR, 1.13; 95% confidence interval, 1.08 to 1.18). Most cancer types showed higher incidences in patients with RCC than in the general population. However, the relative incidence of gastric cancer as an SPC varied by age. Gastric cancer incidence was elevated in young patients (< 30 years) with RCC, but reduced in older (≥ 30) patients with RCC. Patients with advanced RCC died prematurely, regardless of SPC development. In contrast, those with early-stage RCC survived for longer periods, although SPC development affected their post-RCC survival. After SPC development, women had better survival than men.
Conclusion
In Korean patients with primary RCC, the incidence of SPC was 13% higher than the incidence of cancer in the general population. These findings may play important roles in the conduct of follow-up evaluations and education for patients with RCC.

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Maria B. Bengtsen, Dóra K. Farkas, Henrik T. Sørensen, Mette Nørgaard
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Prediction of Cancer Incidence and Mortality in Korea, 2017: Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee; Cancer Res Treat. 2017;49(2):306-312. Published online March 17, 2017; DOI: https://doi.org/10.4143/crt.2017.130

Abstract PDF PubReader ePub

Purpose
This study aimed to report on cancer incidence and mortality for the year 2017 in Korea in order to estimate the nation’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2014 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2015 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observe age-specific cancer rates against observed years, and then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly; we only used data of the latest trend.
Results
A total of 221,143 new cancer cases and 80,268 cancer deaths are expected to occur in Korea in 2017. The most common cancer sites are the colorectum, stomach, lung, thyroid, and breast. These five cancers represent half of the overall burden of cancer in Korea. For mortality, the most common sites are the lung, liver, colorectal, stomach, and pancreas.
Conclusion
The incidence rate of all cancers in Korea appears to have decreased mainly because of a decrease in thyroid cancer. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluation of cancer-control programs.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014: Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries; Cancer Res Treat. 2017;49(2):292-305. Published online March 9, 2017; DOI: https://doi.org/10.4143/crt.2017.118

Abstract PDF PubReader ePub

Purpose
This study presents the 2014 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999 to 2014 was obtained from the Korea National Cancer Incidence Database and followed until December 31, 2015. Mortality data from 1983 to 2014 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2015, among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality, prevalence, and 5-year relative survivals were also calculated.
Results
In 2014, 217,057 and 76,611 Koreans were newly diagnosed and died from cancer respectively. The ASRs for cancer incidence and mortality in 2014 were 270.7 and 85.1 per 100,000, respectively. The all-cancer incidence rate has increased significantly by 3.4% annually from 1999 to 2012, and started to decrease after 2012 (2012-2014; annual percent change, –6.6%). However, overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2010 and 2014 was 70.3%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased since 2012 and mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2010-2014 in Korea.

Citations

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Increased prevalence of metabolic syndrome in adult cancer survivors: Asian first report in community setting
Minkyung Kim, In-Hoo Kim, Min Kyung Lim, Yeol Kim, Boyoung Park
Cancer Epidemiology.2019; 58: 130. CrossRef
Ki-67 labeling index as a prognostic marker in advanced stomach cancer
Sang Hyuk Seo, Kwang Hee Kim, Sang Hoon Oh, Yunseon Choi, Ki Jung Ahn, Ji Young Lee, Sang Min Lee, Jisun Park, Woo Gyeong Kim
Annals of Surgical Treatment and Research.2019; 96(1): 27. CrossRef
Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center
Seung-Hun Song, Dae Keun Kim, Su Ye Sung, Young Sun Her, Ok-Hee Lee, Myoung Hwa Choi, Hae Kyung Kim, Sang Woo Lyu, Dong Suk Kim
The World Journal of Men's Health.2019; 37(2): 219. CrossRef
Association between awareness of nutrition labeling and high-density lipoprotein cholesterol concentration in cancer survivors and the general population: The Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2016
Ji Sung Yoo, Kyu-Tae Han, Seung Hyun Chung, Eun-Cheol Park
BMC Cancer.2019;[Epub] CrossRef
Unexpected malignant uterine pathology: Incidence, characteristics and outcome in a large single-center series of hysterectomies for presumed benign uterine disease
P. Wagner, F.K.F. Kommoss, S. Kommoss, A.D. Hartkopf, I. Pasternak, E. Oberlechner, K. Greif, M. Wallwiener, F. Neis, H. Abele, B. Krämer, C. Reisenauer, A. Staebler, D. Wallwiener, S.Y. Brucker, F.A. Taran
Gynecologic Oncology.2019; 153(1): 49. CrossRef
Randomized Phase III Trial of Irinotecan Plus Cisplatin versus Etoposide Plus Cisplatin in Chemotherapy-Naïve Korean Patients with Extensive-Disease Small Cell Lung Cancer
Dong-Wan Kim, Hoon-Gu Kim, Joo-Hang Kim, Keunchil Park, Hoon-Kyo Kim, Joung Soon Jang, Bong-Seog Kim, Jin-Hyoung Kang, Kyung Hee Lee, Sang-We Kim, Hun Mo Ryoo, Jin-Soo Kim, Ki Hyeong Lee, Jung Hye Kwon, Jin-Hyuk Choi, Sang Won Shin, Seokyung Hahn, Dae Seo
Cancer Research and Treatment.2019; 51(1): 119. CrossRef
Clinical Features and Association with Visceral Malignancy in 80 Patients with Sebaceous Neoplasms
Jee Eun Kim, Jong Hoon Kim, Kee-Yang Chung, Jin Sook Yoon, Mi Ryung Roh
Annals of Dermatology.2019; 31(1): 14. CrossRef
Prognostic significance of pretreatment lymphocyte percentage and age at diagnosis in patients with locally advanced cervical cancer treated with definite radiotherapy
Myung-Hwa Jeong, Hyungjoo Kim, Tae-Hun Kim, Moon-Hong Kim, Beob-Jong Kim, Sang-Young Ryu
Obstetrics & Gynecology Science.2019; 62(1): 35. CrossRef
Cross-national analysis about the difference of histopathological management in Tis and T1 colorectal cancer between Japan and Korea
Naohisa Yoshida, Yuji Naito, Yutaka Inada, Yoshito Itoh, Sang Pyo Lee, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Hye Seung Han, Masayoshi Nakanishi, Mitsuo Kishimoto, Sun-Young Lee
Journal of the Anus, Rectum and Colon.2019; 3(1): 18. CrossRef
Development of a risk scoring system for patients with papillary thyroid cancer
Kyoungjune Pak, Yun Hak Kim, Sunghwan Suh, Tae Sik Goh, Dae Cheon Jeong, Seong Jang Kim, In Joo Kim, Myoung‐Eun Han, Sae‐Ock Oh
Journal of Cellular and Molecular Medicine.2019; 23(4): 3010. CrossRef
Symptom experiences and health‐related quality of life among non‐small cell lung cancer patients participating in clinical trials
Kyunghwa Lee, Eui Geum Oh, Sanghee Kim, Sang‐We Kim
Journal of Clinical Nursing.2019; 28(11-12): 2111. CrossRef
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
British Journal of Cancer.2019; 120(6): 668. CrossRef
Association of Periodontitis with Oral Cancer: A Case-Control Study
Y.J. Shin, H.W. Choung, J.H. Lee, I.C. Rhyu, H.D. Kim
Journal of Dental Research.2019; 98(5): 526. CrossRef
Economic burden of lung cancer: A retrospective cohort study in South Korea, 2002-2015
Soo Min Jeon, Jin-Won Kwon, Sun Ha Choi, Hae-Young Park, Seil Sohn
PLOS ONE.2019; 14(2): e0212878. CrossRef
Relationship Between Preferences for Advance Directive Treatments and Decisional Conflicts Among Low-Income, Home-Based Cancer Management Recipients in Korea
Miyeong Kim, Seongkum Heo, Jung-Yi Hur, JaeLan Shim, JinShil Kim
Journal of Transcultural Nursing.2019; 30(6): 587. CrossRef
Clinical Outcomes of Conversion Surgery after Neoadjuvant Chemotherapy in Patients with Borderline Resectable and Locally Advanced Unresectable Pancreatic Cancer: A Single-Center, Retrospective Analysis
Changhoon Yoo, Sang Hyun Shin, Kyu-pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Jun Ho Kang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Jin-hong Park, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Baek-Yeol Ryoo, Song
Cancers.2019; 11(3): 278. CrossRef
Association of body mass index with bladder cancer risk in men depends on abdominal obesity
Jin Bong Choi, Jung Ho Kim, Sung-Hoo Hong, Kyung-Do Han, U-Syn Ha
World Journal of Urology.2019; 37(11): 2393. CrossRef
Prevalence of Pressure Injuries Nationwide from 2009 to 2015: Results from the National Inpatient Sample Database in Korea
Gyeong Hoe Kim, Jin Yong Lee, Jayeun Kim, Hyun Joo Kim, Ji-Ung Park
International Journal of Environmental Research and Public Health.2019; 16(5): 704. CrossRef
Changes in Bone Mineral Density in Women With Breast Cancer
Soo Hyun Kim, Young Up Cho, Sei Joong Kim, Mi Sook Han
Cancer Nursing.2019; 42(2): 164. CrossRef
The economic burden of cancers attributable to smoking in Korea, 2014
Thi Nguyen, Minji Han, Jin-Kyoung Oh
Tobacco Induced Diseases.2019;[Epub] CrossRef
Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers
Hyeong Sik Ahn, Tae Uk Kang, Heather Swan, Min Ji Kang, Nayoung Kim, Hyun Jung Kim, Seon Mee Park
Pancreas.2019; 48(3): 412. CrossRef
Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma
Sung Joo Kim, Mi-Ju Kim, Ji-Soo Han, You-Na Sung, Soyeon An, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Sang Soo Lee, HyungJun Cho, Song Cheol Kim, James R. Eshleman, Seung-Mo Hong
Pancreas.2019; 48(3): 400. CrossRef
Evaluation of satisfaction with three different cervical cancer screening modalities: clinician-collected Pap test vs. HPV test by self-sampling vs. HPV test by urine sampling
Hye Young Shin, Bomyee Lee, Sang-Hyun Hwang, Dong Ock Lee, Na Young Sung, Jae Young Park, Jae Kwan Jun
Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Genomic Characterization of Differentiated Thyroid Carcinoma
Young Shin Song, Young Joo Park
Endocrinology and Metabolism.2019; 34(1): 1. CrossRef
Risk factors associated with locoregional failure and estimation of survival after curative resection for patients with distal bile duct cancer
Jung Ho Im, Joon Seong Park, Dong Sup Yoon, Dong Ki Lee, Jun Won Kim, Ik Jae Lee
Scientific Reports.2019;[Epub] CrossRef
Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
Hyunjung Kim, Hae Il Jung, Soon Ha Kwon, Sang Ho Bae, Hyung Chul Kim, Moo-Jun Baek, Moon Soo Lee
Annals of Surgical Treatment and Research.2019; 96(4): 191. CrossRef
Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma
Im-kyung Kim, Yun Sun Lee, Hyung Sun Kim, Seung Myung Dong, Joon Seong Park, Dong Sup Yoon
Scientific Reports.2019;[Epub] CrossRef
Salvage Concurrent Chemo-radiation Therapy for Loco-regional Recurrence Following Curative Surgery of Non-small Cell Lung Cancer
Kyung Hwa Lee, Yong Chan Ahn, Hongryull Pyo, Jae Myoung Noh, Seung Gyu Park, Tae Gyu Kim, Eonju Lee, Heerim Nam, Hyebin Lee, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
Cancer Research and Treatment.2019; 51(2): 769. CrossRef
Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma
Changhoon Yoo, Jihoon Kang, Ho Yeong Lim, Jee Hyun Kim, Myung-Ah Lee, Kyung-Hun Lee, Tae-You Kim, Baek-Yeol Ryoo
Cancer Research and Treatment.2019; 51(2): 510. CrossRef
Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database
Byung-Woo Kim, Chang-Mo Oh, Hwa Young Choi, Joong-Won Park, Hyunsoon Cho, Moran Ki
Gut and Liver.2019; 13(1): 104. CrossRef
A retrospective feasibility study of biweekly docetaxel in patients with high-risk metastatic castration-naïve prostate cancer
Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee, Se Hoon Park
BMC Urology.2019;[Epub] CrossRef
Risk of cancer in pre-dialysis chronic kidney disease: A nationwide population-based study with a matched control group
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kyungdo Han, Seoung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Kidney Research and Clinical Practice.2019; 38(1): 60. CrossRef
The economic burden of cancer attributable to obesity in Korea: A population‐based cohort study
Joo Eun Lee, Chung Mo Nam, Sang Gyu Lee, Sohee Park, Tae Hyun Kim, Eun‐Cheol Park
European Journal of Cancer Care.2019;[Epub] CrossRef
Factors for the Early Revision of Misdiagnosed Tuberculosis to Lung Cancer: A Multicenter Study in A Tuberculosis-Prevalent Area
Chin-Chung Shu, Shih-Chieh Chang, Yi-Chun Lai, Cheng-Yu Chang, Yu-Feng Wei, Chung-Yu Chen
Journal of Clinical Medicine.2019; 8(5): 700. CrossRef
Safety of Laparoscopic Oncologic Resection in Elderly Patients with Colorectal Cancer: A Multicenter Retrospective Study Based on Perioperative Short-Term Outcomes
Bong-Hyeon Kye, Thammanij Rookkachart, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Seong-Taek Oh
Journal of Laparoendoscopic & Advanced Surgical Techniques.2019; 29(8): 1016. CrossRef
Performance Evaluation of SENTiFIT 270 and FOB Gold Reagent for Detecting Fecal Occult Blood
Da Young Kang, Dokyun Kim, Keonhan Kim, In-Ho Jang, Seok Hoon Jeong
Annals of Clinical Microbiology.2019; 22(2): 29. CrossRef
Expression of NF2 Modulates the Progression of BRAF V600E Mutated Thyroid Cancer Cells
Mi-Hyeon You, Min Ji Jeon, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
Endocrinology and Metabolism.2019; 34(2): 203. CrossRef
Integrative cancer treatment may have a survival benefit in patients with lung cancer
Kyeore Bae, Eunseok Kim, Ji-Sook Kong, Jeehye Kim, So-jung Park, Hyeong joon Jun, Chong-kwan Cho, Mi Kyung Kim, Hwa-Seung Yoo
Medicine.2019; 98(26): e16048. CrossRef
Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits
Sang Gyun Kim, Da Hyun Lyu, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Youngju Cha, Hwoon-Yong Jung
The Korean Journal of Internal Medicine.2019; 34(4): 785. CrossRef
Clinical Features and Outcomes of Invasive Breast Cancer: Age-Specific Analysis of a Modern Hospital-Based Registry
Ji-Yeon Kim, Danbee Kang, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong Han Yu, Se Kyung Lee, Young-Hyuck Im, Jin Seok Ahn, Eliseo Guallar, Juhee Cho, Yeon Hee Park
Journal of Global Oncology.2019; (5): 1. CrossRef
The Korean–Advance Directive Model and Factors Associated With Its Completion Among Patients With Hematologic Disorders
Mee Ok Lee, Jinny Park, Eun Young Park, Youngji Kim, Eunjoo Bang, Seongkum Heo, JinShil Kim
Journal of Hospice & Palliative Nursing.2019; 21(4): E10. CrossRef
Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection
Jieun Jang, Eun-Jung Cho, Yunji Hwang, Elisabete Weiderpass, Choonghyun Ahn, Jeoungbin Choi, Soung-Hoon Chang, Hai-Rim Shin, Min Kyung Lim, Keun-Young Yoo, Sue K. Park
Cancer Research and Treatment.2019; 51(3): 1107. CrossRef
Clinical and Genetic Characteristics of BRCA1/2 Mutation in Korean Ovarian Cancer Patients: A Multicenter Study and Literature Review
Byung Su Kwon, Jung Mi Byun, Hyun Joo Lee, Dae Hoon Jeong, Tae Hwa Lee, Kyung-Hwa Shin, Dong Soo Suh, Ki Hyung Kim
Cancer Research and Treatment.2019; 51(3): 941. CrossRef
The Health Burden of Cancer Attributable to Obesity in Korea: A Population-Based Cohort Study
Joo Eun Lee, Chung Mo Nam, Sang Gyu Lee, Sohee Park, Tae Hyun Kim, Eun-Cheol Park
Cancer Research and Treatment.2019; 51(3): 933. CrossRef
Interventional radiology for post-gastrectomy complications
Suyoung Park, Ji Hoon Shin, Kichang Han
International Journal of Gastrointestinal Intervention.2019; 8(3): 145. CrossRef
The burdens of tuberculosis on patients with malignancy: incidence, mortality and relapse
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Scientific Reports.2019;[Epub] CrossRef
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, Sang-Jae Park
Gut and Liver.2019; 13(6): 683. CrossRef
Effect of Different Types of Mammography Equipment on Screening Outcomes: A Report by the Alliance for Breast Cancer Screening in Korea
Bo Hwa Choi, Eun Hye Lee, Jae Kwan Jun, Keum Won Kim, Young Mi Park, Hye-Won Kim, You Me Kim, Dong Rock Shin, Hyo Soon Lim, Jeong Seon Park, Hye Jung Kim
Korean Journal of Radiology.2019; 20(12): 1638. CrossRef
Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy
Jae Jun Shin, Young Min Choi, Jong Kwan Jun, Kyung-Hun Lee, Tae-Yong Kim, Wonshik Han, Seock-Ah Im
Journal of Breast Cancer.2019; 22(4): 624. CrossRef
Predictors of Quality of Life and Social Support as a Mediator between Defecation Function and Quality of Life among Rectal Cancer Patients
Jung Rang Kim, Seon Young Hwang
Korean Journal of Adult Nursing.2019; 31(5): 487. CrossRef
Psychometric Evaluation of a Korean Version of the Cancer Survivors' Self-efficacy Scale
Soo Hyun Kim, Bo Gyeong Lee, Ji Yeon Lee, Sei Joong Kim, Min Hee Hur, Moon Hee Lee, Mi Sook Han
Cancer Nursing.2019; 42(6): 509. CrossRef
Do disinfection byproducts in drinking water have an effect on human cancer risk worldwide? A meta‐analysis
Laleh R. Kalankesh, Susana Rodríguez‐Couto, Mohammad Ali Zazouli, Mahmood Moosazadeh, Seyednouraddin Mousavinasab
Environmental Quality Management.2019; 29(2): 105. CrossRef
Relationship between occupational sunlight exposure and the incidence of renal cancer
Hyun-Suk Jang, Jong-Han Leem, Seong Soo Jeon, Shin-Goo Park, Sangyoon Lee, Yangwon Kang, Go Choi, Hyung Doo Kim, Hyeonwoo Ju, Sung Wook Jang, Youna Won, Hwan-Cheol Kim
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef
Correlates of life-support treatment preferences among low-income home-based cancer management recipients
JinShil Kim, Seongkum Heo, Mi Yeong Kim, Eun Young Park, Eun Ju Seo, Mee Ok Lee, Bo Yoon Jeong, Jung-Ah Lee
European Journal of Oncology Nursing.2019; 43: 101665. CrossRef
Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
Hyun Ju Kim, Sang Gyun Kim, Jung Kim, Hyoungju Hong, Hee Jong Lee, Min Seong Kim, Hyunsoo Chung, Hyun Chae Jung, Sudeep Gupta
PLOS ONE.2019; 14(10): e0224614. CrossRef
Association between obstructive sleep apnoea and breast cancer: The Korean National Health Insurance Service Data 2007–2014
Ji Ho Choi, Jae Yong Lee, Kyung Do Han, Young Chang Lim, Jae Hoon Cho
Scientific Reports.2019;[Epub] CrossRef
Risk of Cancers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Results from the Korea National Health Insurance Claims Database 2010–2018
Sung Soo Ahn, Minkyung Han, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Inkyung Jung, Sang-Won Lee
Journal of Clinical Medicine.2019; 8(11): 1871. CrossRef
A Text Mining Analysis of HPV Vaccination Research Trends
Yedong Son, Hee Sun Kang
Child Health Nursing Research.2019; 25(4): 458. CrossRef
A Survey on Current Trends of Breast Imaging Practices in Korea
Bo La Yun, Sun Mi Kim, Mijung Jang, Nariya Cho, Boo-Kyung Han
Journal of the Korean Society of Radiology.2019; 80(5): 919. CrossRef
Resveratrol induces cell death through ROS‑dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells
Thae Kim, Ji Park, Jae Woo
Molecular Medicine Reports.2019;[Epub] CrossRef
Pro‑apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells
Gwangbeom Heo, Dongwan Kang, Chaeun Park, Su Kim, Jieun Choo, Yunna Lee, Jin‑Wook Yoo, Yunjin Jung, Jaewon Lee, Nam Kim, Hae Chung, Hyung Moon, Eunok Im
Oncology Letters.2019;[Epub] CrossRef
Smoking and Urinary Cotinine Levels Are Predictors of Increased Risk for Gastric Intestinal Metaplasia
Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn, Seungho Ryu
Cancer Research.2019; 79(3): 676. CrossRef
Cancer Risk from Exposure to Particulate Matter and Ozone According to Obesity and Health-Related Behaviors: A Nationwide Population-Based Cross-Sectional Study
Kyoung Jin Kim, Jinyoung Shin, Jaekyung Choi
Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 357. CrossRef
Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study
Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn, Seungho Ryu
Cancer Epidemiology, Biomarkers & Prevention.2019; 28(4): 789. CrossRef
A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data
Ji-Man Kang, Johyun Ha, Eun Kyung Hong, Hee Young Ju, Byung Kiu Park, Sang-Hoon Shin, Young-Joo Won, Kyu-Won Jung, Hyeon Jin Park
Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 409. CrossRef
A psychological intervention programme for patients with breast cancer under chemotherapy and at a high risk of depression: A randomised clinical trial
Yeon Hee Kim, Kyung Sook Choi, Kihye Han, Hae Won Kim
Journal of Clinical Nursing.2018; 27(3-4): 572. CrossRef
Necessity of D2 lymph node dissection in older patients ≥ 80 years with gastric cancer
Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
Journal of Geriatric Oncology.2018; 9(2): 115. CrossRef
Mapping patterns of locoregional recurrence following contemporary treatment with radiation therapy for breast cancer: A multi-institutional validation study of the ESTRO consensus guideline on clinical target volume
Jee Suk Chang, Jeongshim Lee, Mison Chun, Kyung Hwan Shin, Won Park, Jong Hoon Lee, Jin Hee Kim, Won Sup Yoon, Ik Jae Lee, Juree Kim, Hye Li Park, Yong Bae Kim
Radiotherapy and Oncology.2018; 126(1): 139. CrossRef
Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014–2016
Yung-Taek Ouh, Kyung-Jin Min, Hyun Woong Cho, Moran Ki, Jin-Kyoung Oh, Sang Yop Shin, Jin Hwa Hong, Jae-Kwan Lee
Journal of Gynecologic Oncology.2018;[Epub] CrossRef
Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells
I. P. Shanura Fernando, K. K. Asanka Sanjeewa, Hyun‐Soo Kim, Lei Wang, Won Woo Lee, You‐Jin Jeon
Journal of Applied Toxicology.2018; 38(4): 527. CrossRef
Cancer incidence in northern Thailand: Results from six population‐based cancer registries 1993–2012
Donsuk Pongnikorn, Karnchana Daoprasert, Narate Waisri, Mathieu Laversanne, Freddie Bray
International Journal of Cancer.2018; 142(9): 1767. CrossRef
Incidental Anterior Mediastinal Nodular Lesions on Chest CT in Asymptomatic Subjects
Soon Ho Yoon, Seung Ho Choi, Chang Hyun Kang, Jin Mo Goo
Journal of Thoracic Oncology.2018; 13(3): 359. CrossRef
Changes in Clinical Characteristics of Patients with an Initial Diagnosis of Prostate Cancer in Korea: 10-Year Trends Reported by a Tertiary Center
Ji Eun Heo, Hyun Kyu Ahn, Jinu Kim, Byung Ha Chung, Kwang Suk Lee
Journal of Korean Medical Science.2018;[Epub] CrossRef
Phase II study of oxaliplatin, irinotecan and S-1 therapy in patients with advanced gastric cancer: the Korean Cancer Study Group ST14-11
Hyeong Su Kim, Min-Hee Ryu, Dae Young Zang, Sook Ryun Park, Boram Han, Won Ki Kang, Sun Young Rha, Minkyu Jung, Jin-Soo Kim, Byung Woog Kang, Kyung-Hee Lee, Sang-Young Rho, Jung Han Kim, Kab Choong Kim, Ji Woong Cho, Dae Ro Choi, Hyun Lim, Ho Suk Kang, Ja
Gastric Cancer.2018; 21(5): 802. CrossRef
Psychiatric comorbidities among ovarian cancer survivors in South Korea: A nationwide population‐based, longitudinal study
Jaesung Heo, Mison Chun, Young‐Taek Oh, O. Kyu Noh, Logyoung Kim
Psycho-Oncology.2018; 27(3): 1021. CrossRef
Sequential spinal and intracranial dural metastases in gastric adenocarcinoma: A case report
Hongsik Kim, Kyung Sik Yi, Won-Dong Kim, Seung-Myoung Son, Yaewon Yang, Jihyun Kwon, Hye Sook Han
World Journal of Gastroenterology.2018; 24(5): 651. CrossRef
Analysis of Motion-dependent Clinical Outcome of Tumor Tracking Stereotactic Body Radiotherapy for Prostate Cancer
Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Jin Ho Song, Yun Hee Lee, In Bong Ha, Sung Chul Kam, Jeong Seok Hwa, Jae Seog Hyun, Jungmo Do, Dong Hyeok Jeong, Hojin Jeong
Journal of Korean Medical Science.2018;[Epub] CrossRef
Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Digestive Diseases and Sciences.2018; 63(4): 1052. CrossRef
A national survey of lung cancer specialists’ views on low-dose CT screening for lung cancer in Korea
Dong Wook Shin, Sohyun Chun, Young Il Kim, Seung Joon Kim, Jung Soo Kim, SeMin Chong, Young Sik Park, Sang-Yun Song, Jin Han Lee, Hee Kyung Ahn, Eun Young Kim, Sei Hoon Yang, Myoung Kyu Lee, Deog Gon Cho, Tae Won Jang, Ji Woong Son, Jeong-Seon Ryu, Moon-J
PLOS ONE.2018; 13(2): e0192626. CrossRef
The prevalence and clinical significance of postgastrectomy anemia in patients with early-stage gastric cancer: A retrospective cohort study
Ji-Hyun Kim, You-Jin Bae, Kyong-Hwa Jun, Hyung-Min Chin
International Journal of Surgery.2018; 52: 61. CrossRef
Budget Impact of the Accreditation Program for Clinical Laboratories on Colorectal Cancer Screening via Fecal Immunochemical Testing: Results from the National Cancer Screening Program in Korea
Jae Kwan Jun, Na Young Sung, Seung Hoon Song, Seri Hong, Mi-Ae Jang, Junghan Song, Jeong-Ho Kim, Won-Ki Min, You Kyoung Lee
Annals of Laboratory Medicine.2018; 38(3): 249. CrossRef
Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells
Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, Kyong-Ah Yoon, Hiromu Suzuki
PLOS ONE.2018; 13(2): e0193275. CrossRef
The Correlation Between Serum Chemokines and Clinical Outcome in Patients with Advanced Biliary Tract Cancer
Su Jin Lee, Jung Eun Kim, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Young Suk Park, Ho Yeong Lim
Translational Oncology.2018; 11(2): 353. CrossRef
Use of complementary and alternative medicine by lymphoma survivors in South Korea
Kisook Kim, Soo Hyun Kim, Oh Nam Ok, Im-Ryung Kim, Suyeon Lee, So Hee Kim, Won Seog Kim, Min-Hee Ryu, Moon Hee Lee
European Journal of Oncology Nursing.2018; 33: 91. CrossRef
Forty‐nine gastric cancer cell lines with integrative genomic profiling for development of c‐MET inhibitor
Hyun Jeong Kim, Sun Kyoung Kang, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Hei‐Cheul Jeung, Michael Kragh, Ivan D. Horak, Hyun Cheol Chung, Sun Young Rha
International Journal of Cancer.2018; 143(1): 151. CrossRef
Pre-treatment anxiety is associated with persistent chemotherapy-induced peripheral neuropathy in women treated with neoadjuvant chemotherapy for breast cancer
Kwang-Min Lee, Dooyoung Jung, Heesung Hwang, Kyung-Lak Son, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Bong-Jin Hahm
Journal of Psychosomatic Research.2018; 108: 14. CrossRef
Comparison of the short-term outcomes of reduced-port laparoscopic surgery and conventional multiport surgery in colon cancer: a propensity score matching analysis
Ji Hoon Kang, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim, Han Deok Kwak, Jae Kyun Ju, Young Jin Kim
Annals of Surgical Treatment and Research.2018; 94(3): 147. CrossRef
Risk of Interval Cancer in Fecal Immunochemical Test Screening Significantly Higher During the Summer Months: Results from the National Cancer Screening Program in Korea
Jae Myung Cha, Mina Suh, Min Seob Kwak, Na Young Sung, Kui Son Choi, Boyoung Park, Jae Kwan Jun, Sang-Hyun Hwang, Do-Hoon Lee, Byung Chang Kim, You Kyoung Lee, Dong Soo Han
American Journal of Gastroenterology.2018; 113(4): 611. CrossRef
Kidney transplantation in patients with diabetes: better than nothing
Chang Seong Kim
The Korean Journal of Internal Medicine.2018; 33(2): 293. CrossRef
Afatinib in heavily pretreated advanced NSCLC patients who progressed following prior gefitinib or erlotinib: Compassionate use program in Korea
Moon Ki Choi, Jin Seok Ahn, Young-Chul Kim, Byoung Chul Cho, In-Jae Oh, Sang-We Kim, Jong Seok Lee, Joo-Hang Kim, Myung-Ju Ahn, Keunchil Park
Lung Cancer.2018; 119: 36. CrossRef
Health-Related Quality of Life in Non-Hodgkin Lymphoma Survivors: A Prospective Cohort Study
Danbee Kang, Juhee Cho, Im Ryung Kim, Mi Kyung Kim, Won Seog Kim, Seok Jin Kim
Cancer Research and Treatment.2018; 50(4): 1051. CrossRef
The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)
Jeanny Kwon, Keun-Young Eom, Young Seok Kim, Won Park, Mison Chun, Jihae Lee, Yong Bae Kim, Won Sup Yoon, Jin Hee Kim, Jin Hwa Choi, Sei Kyung Chang, Bae Kwon Jeong, Seok Ho Lee, Jihye Cha
Cancer Research and Treatment.2018; 50(3): 964. CrossRef
Comparative analysis of Adam33 mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Insight Onco™ NGS
Soo-Jin Kim, Eunhee Kim, Kyung-Taek Rim
Molecular & Cellular Toxicology.2018; 14(2): 221. CrossRef
Predictive Nomogram for Recurrence of Stage I Colorectal Cancer After Curative Resection
Chan Kim, Woo Ram Kim, Ki-Yeol Kim, Hong Jae Chon, Seung Hoon Beom, Hyojoong Kim, Minkyu Jung, Sang Joon Shin, Nam Kyu Kim, Joong Bae Ahn
Clinical Colorectal Cancer.2018; 17(3): e513. CrossRef
Breast Cancer Epidemiology of the Working-Age Female Population Reveals Significant Implications for the South Korean Economy
Jeong Hyun Park, Se Kyung Lee, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Ji-Yeon Kim, Jin-Seok Ahn, Won Park, Jonghan Yu, Yeon Hee Park
Journal of Breast Cancer.2018; 21(1): 91. CrossRef
Successful Robotic Gastrectomy Does Not Require Extensive Laparoscopic Experience
Ji Yeong An, Su Mi Kim, Soohyun Ahn, Min-Gew Choi, Jun-Ho Lee, Tae Sung Sohn, Jae-Moon Bae, Sung Kim
Journal of Gastric Cancer.2018; 18(1): 90. CrossRef
Nab-paclitaxel plus gemcitabine versus FOLFIRINOX as the first-line chemotherapy for patients with metastatic pancreatic cancer: retrospective analysis
Jihoon Kang, Inhwan Hwang, Changhoon Yoo, Kyu-pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Seung-Mo Hong, Sang Hyun Shin, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Song C
Investigational New Drugs.2018; 36(4): 732. CrossRef
The combination of cisplatin and topotecan as a second-line treatment for patients with advanced/recurrent uterine cervix cancer
Ji Young Moon, Ik-Chan Song, Young Bok Ko, Hyo Jin Lee
Medicine.2018; 97(14): e0340. CrossRef
Higher satisfaction with an alternative collection device for stool sampling in colorectal cancer screening with fecal immunochemical test: a cross-sectional study
Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee, Do-Hoon Lee
BMC Cancer.2018;[Epub] CrossRef
Anaplastic lymphoma kinase (ALK)-expressing Lung Adenocarcinoma with Combined Neuroendocrine Component or Neuroendocrine Transformation: Implications for Neuroendocrine Transformation and Response to ALK-tyrosine Kinase Inhibitors
Jongmin Sim, Hyunjin Kim, Jiyeon Hyeon, Yoon-La Choi, Joungho Han
Journal of Korean Medical Science.2018;[Epub] CrossRef
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Cancer Research and Treatment.2018; 50(2): 303. CrossRef
Prediction of Cancer Incidence and Mortality in Korea, 2018
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Cancer Research and Treatment.2018; 50(2): 317. CrossRef
Intracranial control and survival outcome of tyrosine kinase inhibitor (TKI) alone versus TKI plus radiotherapy for brain metastasis of epidermal growth factor receptor-mutant non-small cell lung cancer
SooYoon Sung, Sea-Won Lee, Yoo-Kang Kwak, Jin Hyung Kang, Sook Hee Hong, Yeon-Sil Kim
Journal of Neuro-Oncology.2018; 139(1): 205. CrossRef
Role of Laparoscopic Gastrectomy in Very Elderly Patients with Gastric Cancer Who Have Outlived the Average Lifespan
Dong Jin Kim, Wook Kim
Journal of Gastric Cancer.2018; 18(2): 109. CrossRef
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer
Charles J. Cho, Jaeeun Jung, Lushang Jiang, Eun Ji Lee, Dae-Soo Kim, Byung Sik Kim, Hee Sung Kim, Hwoon-Yong Jung, Ho-June Song, Sung Wook Hwang, Yangsoon Park, Min Kyo Jung, Chan Gi Pack, Seung-Jae Myung, Suhwan Chang
Digestive Diseases and Sciences.2018; 63(7): 1835. CrossRef
The Incidence of Other Primary Cancers in Patients with Cutaneous Lymphoma
Young Jae Kim, Ho Jeong Shin, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Woo Jin Lee
Annals of Dermatology.2018; 30(3): 335. CrossRef
Effects of Heated-Humidified Anesthetic Gas in the Elderly Patients with Colorectal Cancer during Laparoscopic Surgery: Randomized Controlled Trial
Hyo-Sun Park, Younhee Kang
Korean Journal of Adult Nursing.2018; 30(2): 206. CrossRef
Feasibility and accessibility of electronic patient-reported outcome measures using a smartphone during routine chemotherapy: a pilot study
Woo Kyun Bae, Jihyun Kwon, Hyun Woo Lee, Sang-Cheol Lee, Eun-Kee Song, Hyeok Shim, Keun Ho Ryu, Jemin Song, Sungbo Seo, Yaewon Yang, Jong-Hyock Park, Ki Hyeong Lee, Hye Sook Han
Supportive Care in Cancer.2018; 26(11): 3721. CrossRef
Proposal for cervical cancer screening in the era of HPV vaccination
Yung-Taek Ouh, Jae Kwan Lee
Obstetrics & Gynecology Science.2018; 61(3): 298. CrossRef
Updates on Cancer Epidemiology in Korea, 2018
Sun-Seog Kweon
Chonnam Medical Journal.2018; 54(2): 90. CrossRef
Changes in ovarian cancer survival during the 20 years before the era of targeted therapy
Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Myong Cheol Lim, Boram Lee, Kyu-Won Jung, Jae Weon Kim, Sang-Yoon Park, Young-Joo Won
BMC Cancer.2018;[Epub] CrossRef
Factors related to cancer screening behaviors
Boyoung Choi, Tae Rim Um, Kwang-Soo Lee
Epidemiology and Health.2018; 40: e2018011. CrossRef
Screening Upper Endoscopy for Early Detection of Gastric Cancer
Jeong Seop Moon
Journal of Korean Medical Science.2018;[Epub] CrossRef
Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea
Whi-An Kwon, Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
BMC Cancer.2018;[Epub] CrossRef
Effect of mammography screening on stage at breast cancer diagnosis: results from the Korea National Cancer Screening Program
Kui Son Choi, Minjoo Yoon, Seung Hoon Song, Mina Suh, Boyoung Park, Kyu Won Jung, Jae Kwan Jun
Scientific Reports.2018;[Epub] CrossRef
Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: a retrospective cohort study
Anna Song, Wankyu Eo, Sehyun Kim, Bumsang Shim, Sookyung Lee
BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef
Treatment patterns and outcomes in patients with metastatic gastric cancer receiving third-line chemotherapy: A population-based outcomes study
In Sil Choi, Mihong Choi, Ju Hyun Lee, Jee Hyun Kim, Koung Jin Suh, Ji Yun Lee, Beodeul Kang, Ji-Won Kim, Se-Hyun Kim, Jin Won Kim, Jeong-Ok Lee, Yu Jung Kim, Soo-Mee Bang, Jong Seok Lee, Keun-Wook Lee, Ju-Seog Lee
PLOS ONE.2018; 13(6): e0198544. CrossRef
A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma
Seung Jae Lee, Si Young Lim, Tae Kyung Yoo, Seul Ki Kim, You Gyung Kim, Hyun Joo Lee, Jae Uk Song
The Korean Journal of Medicine.2018; 93(3): 300. CrossRef
Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database
Aesun Shin, Young‐Joo Won, Hye‐Kyung Jung, Hyun‐Joo Kong, Kyu‐Won Jung, Chang‐Mo Oh, Sunho Choe, Jihyun Lee
Journal of Gastroenterology and Hepatology.2018; 33(12): 1961. CrossRef
Radiological Report of Pilot Study for the Korean Lung Cancer Screening (K-LUCAS) Project: Feasibility of Implementing Lung Imaging Reporting and Data System
Ji Won Lee, Hyae Young Kim, Jin Mo Goo, Eun Young Kim, Soo Jung Lee, Tae Jung Kim, Yeol Kim, Juntae Lim
Korean Journal of Radiology.2018; 19(4): 803. CrossRef
A Randomized Phase 2 Trial of Consolidation Chemotherapy After Preoperative Chemoradiation Therapy Versus Chemoradiation Therapy Alone for Locally Advanced Rectal Cancer: KCSG CO 14-03
Sun Young Kim, Jungnam Joo, Tae Won Kim, Yong Sang Hong, Jeong Eun Kim, In Gyu Hwang, Beom Gyu Kim, Keun-Wook Lee, Ji-Won Kim, Ho-Suk Oh, Joong Bae Ahn, Dae Young Zang, Dae Yong Kim, Jae Hwan Oh, Ji Yeon Baek
International Journal of Radiation Oncology*Biology*Physics.2018; 101(4): 889. CrossRef
The influence of diabetes and antidiabetic medications on the risk of pancreatic cancer: a nationwide population-based study in Korea
Da Young Lee, Ji Hee Yu, Sanghyun Park, Kyungdo Han, Nam Hoon Kim, Hye Jin Yoo, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim, Ji A. Seo
Scientific Reports.2018;[Epub] CrossRef
Status of BRCA1/2 Genetic Testing Practices in Korea (2014)
Kyungju Lee, Ja-Hyun Jang, Seung-Tae Lee, Kyong-Ah Yoon, Eun Sook Lee, Jong-Won Kim, Sun-Young Kong
Laboratory Medicine Online.2018; 8(3): 107. CrossRef
How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis
Jae-Eun Lee
Osong Public Health and Research Perspectives.2018; 9(3): 105. CrossRef
External validation of IBTR! 2.0 nomogram for prediction of ipsilateral breast tumor recurrence
Byung Min Lee, Jee Suk Chang, Young Up Cho, Seho Park, Hyung Seok Park, Jee Ye Kim, Joo Hyuk Sohn, Gun Min Kim, Ja Seung Koo, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
Radiation Oncology Journal.2018; 36(2): 139. CrossRef
Survival Trends in Gastric Adenocarcinoma: A Population-Based Study in Sweden
Johannes Asplund, Joonas H. Kauppila, Fredrik Mattsson, Jesper Lagergren
Annals of Surgical Oncology.2018; 25(9): 2693. CrossRef
A comparative study of the clinical characteristics of breast cancer patients less than 35 years old and older patients
Tae Sik Hwang, Ah Rem Jeong, Joung Won Na, Yun Yeong Kim, Joon-Hyop Lee, Yoo Seung Chung, Sang Tae Choi, Jin Mo Kang, Heung Kyu Park, Yong Soon Chun
Korean Journal of Clinical Oncology.2018; 14(1): 1. CrossRef
Metastatic colon cancer of an ovarian cancer origin mimicking primary colon cancer: A case report
Ji-Hyeon Park, Dong Hae Jung, Jeong-Heum Baek
Korean Journal of Clinical Oncology.2018; 14(1): 53. CrossRef
Relationships among Mood Status, Social Support, Symptom Experience and Quality of Life in Colorectal Cancer Patients - based on the Theory of Unpleasant Symptoms
Hyun Jeong Seo, Eun Jung Ryu, Mi Young Ham
Asian Oncology Nursing.2018; 18(2): 104. CrossRef
Long-Term Clinical Outcomes of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer: A Prospective Multicenter Cohort Study
Sang Gyun Kim, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Da Hyun Lyu, Seung-Hee Park, Il Ju Choi, Wan Sik Lee, Seun Ja Park, Jae Jun Kim, Ji Hyun Kim, Chul-Hyun Lim, Joo Young Cho, Gwang Ha Kim, Yong Chan Lee, Hwoon-Yong Jung, Jun Haeng Lee, Hoon Jai Chun, S
Gut and Liver.2018; 12(4): 402. CrossRef
Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells
I.P. Shanura Fernando, K.K. Asanka Sanjeewa, Yong-Seok Ann, Chang-ik Ko, Seung-Hong Lee, Won Woo Lee, You-Jin Jeon
Toxicology in Vitro.2018; 52: 297. CrossRef
Necessity of adjuvant concurrent chemo-radiotherapy in D2-resected LN-positive gastric cancer
Jeong Il Yu, Do Hoon Lim, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Seung Tae Kim, Su Jin Lee, Sung Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Hye Seung Kim, Soohyun Ahn
Radiotherapy and Oncology.2018; 129(2): 306. CrossRef
Decreasing Disease-Specific Mortality of Differentiated Thyroid Cancer in Korea: A Multicenter Cohort Study
Min Ji Jeon, Hee Kyung Kim, Eun Heui Kim, Eun Sook Kim, Hyon-Seung Yi, Tae Yong Kim, Ho-Cheol Kang, Young Kee Shong, Won Bae Kim, Bo Hyun Kim, Won Gu Kim
Thyroid.2018; 28(9): 1121. CrossRef
Marked Loss of Muscle, Visceral Fat, or Subcutaneous Fat After Gastrectomy Predicts Poor Survival in Advanced Gastric Cancer: Single-Center Study from the CLASSIC Trial
Hyung Soon Park, Hyo Song Kim, Seung Hoon Beom, Sun Young Rha, Hyun Cheol Chung, Jee Hung Kim, You Jin Chun, Si Won Lee, Eun-Ah Choe, Su Jin Heo, Sung Hoon Noh, Woo Jin Hyung, Jae-Ho Cheong, Hyoung-Il Kim, Taeil Son, Joon Seok Lim, Song-Ee Baek, Minkyu Ju
Annals of Surgical Oncology.2018; 25(11): 3222. CrossRef
Association Between Fusobacterium nucleatum, Pathway Mutation, and Patient Prognosis in Colorectal Cancer
Dae-Won Lee, Sae-Won Han, Jun-Kyu Kang, Jeong Mo Bae, Hwang-Phill Kim, Jae-Kyung Won, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim
Annals of Surgical Oncology.2018; 25(11): 3389. CrossRef
Adjuvant Chemotherapy Versus Chemoradiation for Patients with Resected Pancreatic Adenocarcinoma: A Single-Center Retrospective Study
Do Young Kim, Young Jin Choi, Young Mi Seol, Hyojeong Kim
The Korean Journal of Pancreas and Biliary Tract.2018; 23(3): 108. CrossRef
Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(4): 169. CrossRef
Disparities in Cervical Cancer Screening Among Women With Disabilities: A National Database Study in South Korea
Dong Wook Shin, Jeong-Won Lee, Jin Hyung Jung, Kyungdo Han, So Young Kim, Kui Son Choi, Jong Heon Park, Jong Hyock Park
Journal of Clinical Oncology.2018; 36(27): 2778. CrossRef
Real-world treatment patterns for patients 80 years and older with early lung cancer: a nationwide claims study
Kyungjong Lee, Hye Ok Kim, Hee Kyoung Choi, Gi Hyeon Seo
BMC Pulmonary Medicine.2018;[Epub] CrossRef
Novel graded prognostic assessment for colorectal cancer patients with brain metastases
Byoung Hyuck Kim, Hae Jin Park, Kyubo Kim, Sae-Won Han, Tae-You Kim, Seung-Yong Jeong, Kyu Joo Park, Eui Kyu Chie
International Journal of Clinical Oncology.2018; 23(6): 1112. CrossRef
BRCA1/2 mutations, including large genomic rearrangements, among unselected ovarian cancer patients in Korea
Do-Hoon Kim, Chi-Heum Cho, Sun Young Kwon, Nam-Hee Ryoo, Dong-Seok Jeon, Wonmok Lee, Jung-Sook Ha
Journal of Gynecologic Oncology.2018;[Epub] CrossRef
Three-Port Right-Side Approach-Duet Totally Laparoscopic Distal Gastrectomy for Uncut Roux-en-Y Reconstruction
Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
Journal of Laparoendoscopic & Advanced Surgical Techniques.2018; 28(9): 1109. CrossRef
Preoperative Nodal 18F-FDG Avidity Rather than Primary Tumor Avidity Determines the Prognosis of Patients with Advanced Gastric Cancer
Hyun Woo Kwon, Liang An, Hye Ryeong Kwon, Sungsoo Park, Sungeun Kim
Journal of Gastric Cancer.2018; 18(3): 218. CrossRef
Comparison of cervical cancer screening among women with and without hysterectomies: a nationwide population-based study in Korea
Ji-Yeon Shin, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun
BMC Cancer.2018;[Epub] CrossRef
Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential
Soon-Chan Kim, Chang-Won Hong, Sang-Geun Jang, Ye-Ah Kim, Byong-Chul Yoo, Young-Kyoung Shin, Seung-Yong Jeong, Ja-Lok Ku, Jae-Gahb Park
Translational Oncology.2018; 11(5): 1232. CrossRef
Association between the Dietary Inflammatory Index and Risk for Cancer Recurrence and Mortality among Patients with Breast Cancer
Hyeonjeong Jang, Min Sung Chung, Shin Sook Kang, Yongsoon Park
Nutrients.2018; 10(8): 1095. CrossRef
Breast Ultrasound Computer-Aided Diagnosis: Analysis of Types of Errors
Min Kyung Jeong, Bong Joo Kang, Eunjeong Kim, Sung Hun Kim
Journal of the Korean Society of Radiology.2018; 79(3): 114. CrossRef
Nurse-led interventions on quality of life for patients with cancer
Xiuju Cheng, Shougang Wei, Huapeng Zhang, Senyao Xue, Wei Wang, Kaikai Zhang
Medicine.2018; 97(34): e12037. CrossRef
Prevalence and risk factors for upper gastrointestinal diseases in health check-up subjects: a nationwide multicenter study in Korea
Kwangwoo Nam, Jeong Eun Shin, Sung Eun Kim, Gwang Ho Baik, Sang Hyeon Choi, Ju Yup Lee, Kyung Sik Park, Young-Eun Joo, Dae-Seong Myung, Hyeon Ju Kim, Hyun Joo Song, Suck Chei Choi, Hyun Jin Kim, Hyun Young Kim, Nayoung Kim
Scandinavian Journal of Gastroenterology.2018; 53(8): 910. CrossRef
Lymphovascular Invasion Increases the Risk of Nodal and Distant Recurrence in Node-Negative Stage I–IIA Non-Small-Cell Lung Cancer
Soo Yoon Sung, Yoo-Kang Kwak, Sea-Won Lee, In Young Jo, Jae Kil Park, Kyung Soo Kim, Kyo Young Lee, Yeon-Sil Kim
Oncology.2018; 95(3): 156. CrossRef
Colonoscopy education for surgical residents in Korea: a national survey of Korean Surgical Skill Study Group
Duck-Woo Kim, Min Hyun Kim, Hyun Ae Kim, Kil Yeon Lee, Seung-Yong Jeong, Woo Yong Lee
Annals of Surgical Treatment and Research.2018; 95(3): 121. CrossRef
Socioeconomic Inequalities in Stomach Cancer Screening in Korea, 2005–2015: After the Introduction of the National Cancer Screening Program
Eun-young Lee, Yoon Young Lee, Mina Suh, Eunji Choi, Tran Thi Xuan Mai, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Jin Kyung Oh, Moran Ki, Kui Son Choi
Yonsei Medical Journal.2018; 59(8): 923. CrossRef
Evaluation of various kinetic parameters of CA-125 in patients with advanced-stage ovarian cancer undergoing neoadjuvant chemotherapy
Yong Jae Lee, In Ha Lee, Yun-Ji Kim, Young Shin Chung, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Surinder K. Batra
PLOS ONE.2018; 13(9): e0203366. CrossRef
Clinical Significance of Circulating Tumor Cells in Gastric Cancer
Hye Kyung Jeon, Gwang Ha Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2018; 18(3): 162. CrossRef
Noncontrast magnetic resonance imaging versus ultrasonography for hepatocellular carcinoma surveillance (MIRACLE-HCC): study protocol for a prospective randomized trial
Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh, Myeong-Jin Kim
BMC Cancer.2018;[Epub] CrossRef
Factors Affecting Endoscopic Curative Resection of Gastric Cancer in the Population-Based Screening Era
Yoon Gwon Mun, Myung-Gyu Choi, Chul-Hyun Lim, Han Hee Lee, Dong Hoon Kang, Jae Myung Park, Kyo Young Song
Clinical Endoscopy.2018; 51(5): 478. CrossRef
The role of third-line chemotherapy in recurrent or metastatic gastric cancer
Yong Won Choi, Mi Sun Ahn, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Seok Yun Kang, Joon Seong Park, Jin-Hyuk Choi, Seung Soo Sheen
Medicine.2018; 97(39): e12588. CrossRef
Primary malignant peripheral nerve sheath tumor of prostate in a young adult
Hyojeong Kim, Do Young Kim, Young Mi Seol, Ja Yoon Ku, Kyung Un Choi, Young Jin Choi
Medicine.2018; 97(39): e12040. CrossRef
BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts
Joo-Yeon Lee, Jisun Kim, Sung-Won Kim, Sue K. Park, Sei Hyun Ahn, Min Hyuk Lee, Young Jin Suh, Dong-Young Noh, Byung Ho Son, Young Up Cho, Sae Byul Lee, Jong Won Lee, John L. Hopper, Joohon Sung
Scientific Reports.2018;[Epub] CrossRef
Effect of Smoking Cessation and Reduction on the Risk of Cancer in Korean Men: A Population Based Study
Seulggie Choi, Jooyoung Chang, Kyuwoong Kim, Sang Min Park, Kiheon Lee
Cancer Research and Treatment.2018; 50(4): 1114. CrossRef
Trends in Gastric Cancer Incidence According to the Clinicopathological Characteristics in Korea, 1999-2014
Bang Wool Eom, Kyu-Won Jung, Young-Joo Won, Hannah Yang, Young-Woo Kim
Cancer Research and Treatment.2018; 50(4): 1343. CrossRef
Phase II Study of Dovitinib in Patients with Castration-Resistant Prostate Cancer (KCSG-GU11-05)
Yoon Ji Choi, Hye Sook Kim, Se Hoon Park, Bong-Seog Kim, Kyoung Ha Kim, Hyo Jin Lee, Hong Suk Song, Dong-Yeop Shin, Ha Young Lee, Hoon-Gu Kim, Kyung Hee Lee, Jae Lyun Lee, Kyong Hwa Park
Cancer Research and Treatment.2018; 50(4): 1252. CrossRef
Socioeconomic Inequalities in Cervical and Breast Cancer Screening among Women in Korea, 2005–2015
Eunji Choi, Yoon Young Lee, Mina Suh, Eun Young Lee, Tran Thi Xuan Mai, Moran Ki, Jin-Kyoung Oh, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
Yonsei Medical Journal.2018; 59(9): 1026. CrossRef
Socioeconomic Inequalities in Colorectal Cancer Screening in Korea, 2005–2015: After the Introduction of the National Cancer Screening Program
Tran Thi Xuan Mai, Yoon Young Lee, Mina Suh, Eunji Choi, Eun Young Lee, Moran Ki, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Jin-Kyoung Oh, Kui Son Choi
Yonsei Medical Journal.2018; 59(9): 1034. CrossRef
Acupuncture for the Treatment of Taxane‐Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Trial
Young Ju Jeong, Min Ah Kwak, Jung Chul Seo, Seong Hoon Park, Jin Gu Bong, Im Hee Shin, Sung Hwan Park, Sven Schröder
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
Eighth edition of tumor-node-metastasis staging system improve survival predictability for papillary, but not follicular thyroid carcinoma: A multicenter cohort study
Mijin Kim, Hye In Kim, Min Ji Jeon, Hee Kyung Kim, Eun Heui Kim, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Bo Hyun Kim, Tae Yong Kim, Sun Wook Kim, Ho-Cheol Kang, Won Bae Kim, Jae Hoon Chung, Young Kee Shong, Tae Hyuk Kim, Won Gu Kim
Oral Oncology.2018; 87: 97. CrossRef
Occupational cancer claims in Korea from 2010 to 2016
Kyungjoon Lee, Sujin Lee, Jeehee Min, Inah Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
Rate and Structure of Mortality from Malignant Neopasms of Lymphatic and Haematopoietic Tissue in the Regions of the Republic of Bashkortostan (2006–2015)
R. A. Maier, A. F. Baibulatova, B. A. Bakirov
Creative surgery and oncology.2018; 8(2): 52. CrossRef
Cancer risk after renal transplantation in South Korea: a nationwide population-based study
Jaesung Heo, O Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
BMC Nephrology.2018;[Epub] CrossRef
Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
Kyeong A So, Seon Ah Kim, Yoo Kyung Lee, In Ho Lee, Ki Heon Lee, Jee Eun Rhee, Mee Kyung Kee, Chi Heum Cho, Sung Ran Hong, Chang Sun Hwang, Mi Seon Jeong, Ki Tae Kim, Moran Ki, Soo Young Hur, Jong Sup Park, Tae Jin Kim
Obstetrics & Gynecology Science.2018; 61(6): 662. CrossRef
Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer
Huapyong Kang, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jeong Youp Park
World Journal of Gastrointestinal Oncology.2018; 10(11): 421. CrossRef
Clinical and Laboratory Characteristics and Mortality in Korean Patients with Systemic Sclerosis: A Nationwide Multicenter Retrospective Cohort Study
Ki Won Moon, Shin-Seok Lee, Yun Jong Lee, Jae-Bum Jun, Su-Jin Yoo, Ji Hyeon Ju, Sung Hae Chang, In Ah Choi, Tae Young Kang, Eun Bong Lee, Seung-Geun Lee
The Journal of Rheumatology.2018; 45(9): 1281. CrossRef
Recent treatment patterns and survival outcomes in pancreatic cancer according to clinical stage based on single-center large-cohort data
Doo-ho Lee, Jin-Young Jang, Jae Seung Kang, Jae Ri Kim, Youngmin Han, Eunjung Kim, Wooil Kwon, Sun-Whe Kim
Annals of Hepato-Biliary-Pancreatic Surgery.2018; 22(4): 386. CrossRef
Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma
Eun Young Kim, Arum Kim, Gaeun Lee, Hangsuck Lee, Yoon Soo Chang
BMC Cancer.2018;[Epub] CrossRef
Efficacy of Intraoperative Neural Monitoring (IONM) in Thyroid Surgery: the Learning Curve
Min Kyu Kwak, Song Jae Lee, Chang Myeon Song, Yong Bae Ji, Kyung Tae
International Journal of Thyroidology.2018; 11(2): 130. CrossRef
Evaluation of Surgical Completeness in Endoscopic Total Thyroidectomy with Central Neck Dissection via a Unilateral Axillo-Breast Approach Compared with Bilateral Axillo-Breast and Open Approach
Ik Joon Choi, Ilhan Lim, Byeong-Cheol Lee, Guk Haeng Lee, Myung-Chul Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2018; 61(12): 697. CrossRef
Clinical relevance of Lgr5 expression in colorectal cancer patients
Young Joo Kim, Dong Hyun Kang, Geum Jong Song, Tae Sung Ahn, Myoung Won Son, Moon Soo Lee, Moo-Jun Baek
Korean Journal of Clinical Oncology.2018; 14(2): 76. CrossRef
Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection
Jung Ho Park, Hyoung-Chul Park, Sung Chan Park, Jae Hwan Oh, Duck-Woo Kim, Sung-Bum Kang, Seung Chul Heo, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
Annals of Coloproctology.2018; 34(6): 286. CrossRef
National Epidemiologic Survey of Thyroid cancer (NEST) in Korea
Chang-Mo Oh, Hyun-Joo Kong, Eunyang Kim, Hyejin Kim, Kyu-Won Jung, Sohee Park, Young-Joo Won
Epidemiology and Health.2018; 40: e2018052. CrossRef
Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee
Genomics & Informatics.2018; 16(4): e35. CrossRef
Optimal Starting Age for Colorectal Cancer Screening in an Era of Increased Metabolic Unhealthiness: A Nationwide Korean Cross-Sectional Study
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
Gut and Liver.2018; 12(6): 655. CrossRef
Effects of 17beta;-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model
Chin-Hee Song, Nayoung Kim, Sung Hwa Sohn, Sun Min Lee, Ryoung Hee Nam, Hee Young Na, Dong Ho Lee, Young-Joon Surh
Gut and Liver.2018; 12(6): 682. CrossRef
Risk of Malnutrition after Gastrointestinal Cancer Surgery: A Propensity Score Matched Retrospective Cohort Study
Sung-Hoon Yoon, Bong-Hyeon Kye, Hyung-Jin Kim, Kyong-Hwa Jun, Hyeon-Min Cho, Hyung-Min Chin
Surgical Metabolism and Nutrition.2018; 9(1): 16. CrossRef
Validation of Administrative Big Database for Colorectal Cancer Searched by International Classification of Disease 10th Codes in Korean: A Retrospective Big-cohort Study
Young-Jae Hwang, Nayoung Kim, Chang Yong Yun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Il Tae Son, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee, Seon Mee Park, Dong Ho Lee
Journal of Cancer Prevention.2018; 23(4): 183. CrossRef
Prognostic Implications of Multiplex Detection of KRAS Mutations in Cell-Free DNA from Patients with Pancreatic Ductal Adenocarcinoma
Min Kyeong Kim, Sang Myung Woo, Boram Park, Kyong-Ah Yoon, Yun-Hee Kim, Jungnam Joo, Woo Jin Lee, Sung-Sik Han, Sang-Jae Park, Sun-Young Kong
Clinical Chemistry.2018; 64(4): 726. CrossRef
EGFR mutation decreases FDG uptake in non‑small cell lung cancer via the NOX4/ROS/GLUT1 axis
Long Chen, Yongchun Zhou, Xiaoxia Tang, Conghui Yang, Yadong Tian, Ran Xie, Ting Chen, Jiapeng Yang, Mingwei Jing, Fukun Chen, Chun Wang, Hua Sun, Yunchao Huang
International Journal of Oncology.2018;[Epub] CrossRef
Molecular Basis of Alcohol-Related Gastric and Colon Cancer
Hye-Kyung Na, Ja Lee
International Journal of Molecular Sciences.2017; 18(6): 1116. CrossRef
Second Primary Cancer Screening: Role of the Primary Care Physician
Seung-Won Oh
Korean Journal of Family Medicine.2017; 38(3): 109. CrossRef
Opioid Withdrawal Symptoms after Conversion to Oral Oxycodone/Naloxone in Advanced Cancer Patients Receiving Strong Opioids
Jung Hoon Kim, Haana Song, Gyeong-Won Lee, Jung Hun Kang
The Korean Journal of Hospice and Palliative Care.2017; 20(2): 131. CrossRef
Thyroid function after TSH suppression for thyroid cancer: When is optimal time to check?
Laura Sterian Ward, Danilo Villagelin
Clinical Endocrinology.2017; 87(3): 231. CrossRef
Validity of self-reported cancer history in the health examinees (HEXA) study: A comparison of self-report and cancer registry records
Sooyoung Cho, Aesun Shin, Daesub Song, Jae Kyung Park, Yeonjung Kim, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee
Cancer Epidemiology.2017; 50: 16. CrossRef
External Validation of a Gastric Cancer Nomogram Derived from a Large-volume Center Using Dataset from a Medium-volume Center
Pyeong Su Kim, Kyung-Muk Lee, Dong-Seok Han, Moon-Won Yoo, Hye Seung Han, Han-Kwang Yang, Ho Yoon Bang
Journal of Gastric Cancer.2017; 17(3): 204. CrossRef
Strategies for Appropriate Patient-centered Care to Decrease the Nationwide Cost of Cancers in Korea
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2017; 50(4): 217. CrossRef
Changes in standardized mortality rates from thyroid cancer in Korea between 1985 and 2015: Analysis of Korean national data
Yun Mi Choi, Won Gu Kim, Hyemi Kwon, Min Ji Jeon, Minkyu Han, Tae Yong Kim, Young Kee Shong, Sang Mo Hong, Eun‐Gyoung Hong, Won Bae Kim
Cancer.2017; 123(24): 4808. CrossRef
Stress and Depressive Symptoms in Cancer Survivors and Their Family Members: Korea Community Health Survey, 2012
Mi Han
International Journal of Environmental Research and Public Health.2017; 14(9): 999. CrossRef
Karyopherin α-2 is a reliable marker for identification of patients with high-risk stage II colorectal cancer
Dongjun Jeong, Hyeongjoo Kim, Seona Ban, Seunghyun Oh, Sanghee Ji, Doyeon Kim, Tae Sung Ahn, Han Jo Kim, Sang Byung Bae, Hyog Young Kwon, Jungkyun Im, Moon Soo Lee, Hyun Deuk Cho, Chang-Jin Kim, Moo-Jun Baek
Journal of Cancer Research and Clinical Oncology.2017; 143(12): 2493. CrossRef
Second primary cancer after liver transplantation in hepatocellular carcinoma: a nationwide population-based study
Jaesung Heo, O. Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
Hepatology International.2017; 11(6): 523. CrossRef
Association Between Health Behaviors and Family History of Cancer in Cancer Survivors: Data From the Korean Genome and Epidemiology Study
Minji Hwang, Boyoung Park
Journal of Cancer Prevention.2017; 22(3): 166. CrossRef
Insulin Resistance Associated With Differentiated Thyroid Carcinoma: Penalized Conditional Logistic Regression Analysis of a Matched Case-Control Study Data
Zahra Heidari, Mahdi Abdani, Mohammad Ali Mansournia
International Journal of Endocrinology and Metabolism.2017;[Epub] CrossRef
Phase II, multicentre, randomised trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy in patients with HER2-negative metastatic breast cancer
Yeon Hee Park, Seock-Ah Im, Sung-Bae Kim, Joo Hyuk Sohn, Keun Seok Lee, Yee Soo Chae, Ki Hyeong Lee, Jee Hyun Kim, Young-Hyuck Im, Ji-Yeon Kim, Tae-Yong Kim, Kyung-Hun Lee, Jin-Hee Ahn, Gun Min Kim, In Hae Park, Soo Jung Lee, Hye Sook Han, Se Hyun Kim, Ky
European Journal of Cancer.2017; 86: 385. CrossRef
Screening strategy for colorectal cancer according to risk
Dong Soo Han
Journal of the Korean Medical Association.2017; 60(11): 893. CrossRef
Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea
Tae Yong Kim, Young Kee Shong
Endocrinology and Metabolism.2017; 32(4): 399. CrossRef
Treatment Patterns and Outcomes in Elderly Patients with Metastatic Breast Cancer: A Multicenter Retrospective Study
Jin Hyun Park, In Sil Choi, Ki Hwan Kim, Jin-Soo Kim, Kyung-Hun Lee, Tae-Yong Kim, Seock-Ah Im, Se Hyun Kim, Yu Jung Kim, Jee Hyun Kim
Journal of Breast Cancer.2017; 20(4): 368. CrossRef
Dietary supplement use among cancer survivors and the general population: a nation-wide cross-sectional study
Sihan Song, Jiyoung Youn, Yun Jung Lee, Minji Kang, Taisun Hyun, YoonJu Song, Jung Eun Lee
BMC Cancer.2017;[Epub] CrossRef
Gastric Cancer Recurrence in 12 Years after Surgical Resection
Ki Hwan Ku, Seun Ja Park, Jae Hyun Kim, Hye Jung Kwon, Hee Kyung Chang, Jung Gu Park
The Korean Journal of Gastroenterology.2017; 70(6): 296. CrossRef
Treatment with Cisplatin and Etoposide Chemotherapy in Patient with Metastatic Breast Cancer
Mi Kim, Jin-sun Lee
Journal of Breast Disease.2017; 5(2): 39. CrossRef
Comparison of post-surgery follow-up methods in patients aged 80 years or older with non-metastatic colorectal cancer
Dong Min Seo, Ji Won Park, Dong Woon Lee, Yoon-Hye Kwon, In Ho Song, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Korean Journal of Clinical Oncology.2017; 13(2): 102. CrossRef
Secular Trends for Diagnostic Motives and Environmental Risk Factors in Thyroid Cancer Using Questionnaire Survey
Hana Kim, Yul Hwangbo, Sung Hye Kong, Young Shin Song, Min Joo Kim, Sun Wook Cho, You Jin Lee, Ka Hee Yi, Do Joon Park, Eun Kyung Lee, Young Joo Park
International Journal of Thyroidology.2017; 10(2): 82. CrossRef
Clinicopathological impacts of high c-Met expression in head and neck squamous cell carcinoma: a meta-analysis and review
Jung Han Kim, Bum Jun Kim, Hyeong Su Kim
Oncotarget.2017; 8(68): 113120. CrossRef
The role of anti-EGFR agents in patients with locoregionally advanced head and neck cancer: a meta-analysis of randomized trials
Bum Jun Kim, Jae Ho Jeong, Hyeong Su Kim, Jung Han Kim
Oncotarget.2017; 8(60): 102371. CrossRef
The role of anti-EGFR agents in the first-line treatment of advanced esophago-gastric adenocarcinoma: a meta-analysis
Bum Jun Kim, Jung Han Kim, Hyun Joo Jang, Hyeong Su Kim
Oncotarget.2017; 8(58): 99033. CrossRef
Prognostic value of c-Met overexpression in hepatocellular carcinoma: a meta-analysis and review
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim, Hyun Joo Jang, Jin Lee
Oncotarget.2017; 8(52): 90351. CrossRef
Clinicopathological impacts of high c-Met expression in renal cell carcinoma: a meta-analysis and review
Jung Han Kim, Bum Jun Kim, Hyeong Su Kim
Oncotarget.2017; 8(43): 75478. CrossRef
Molecular targeted agents as second-line treatment for hepatocellular carcinoma: a meta-analysis and review
Jung Han Kim, Bum Jun Kim, Hyun Joo Jang, Jin Lee
Oncotarget.2017; 8(60): 102321. CrossRef
Prognostic value of smoking status in non-small-cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim
Oncotarget.2017; 8(54): 93149. CrossRef
The addition of bevacizumab in the first-line treatment for metastatic colorectal cancer: an updated meta-analysis of randomized trials
Hyun Joo Jang, Bum Jun Kim, Jung Han Kim, Hyeong Su Kim
Oncotarget.2017; 8(42): 73009. CrossRef
MET inhibitors in advanced non-small-cell lung cancer: a meta-analysis and review
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim
Oncotarget.2017; 8(43): 75500. CrossRef
Survival benefit of anti-angiogenic agents in patients with previously treated advanced gastric or gastroesophageal junction cancer: a meta-analysis
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim, Hyun Joo Jang
Oncotarget.2017; 8(57): 97565. CrossRef
Prognostic value of c-Met overexpression in pancreatic adenocarcinoma: a meta-analysis
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim, Jin Lee, Hyun Joo Jang
Oncotarget.2017; 8(42): 73098. CrossRef
Korean OBEsity Surgical Treatment Study (KOBESS): protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass
Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo
BMJ Open.2017; 7(10): e018044. CrossRef
Occupational radiation exposure and its health effects on interventional medical workers: study protocol for a prospective cohort study
Seulki Ko, Hwan Hoon Chung, Sung Bum Cho, Young Woo Jin, Kwang Pyo Kim, Mina Ha, Ye Jin Bang, Yae Won Ha, Won Jin Lee
BMJ Open.2017; 7(12): e018333. CrossRef
N of 1 case reports of exceptional responders accrued from pancreatic cancer patients enrolled in first-in-man studies from 2002 through 2012
Ignacio Garrido-Laguna, Danielle Tometich, Nan Hu, Jian Ying, Katherine Geiersbach, Jonathan Whisenant, Kai Wang, Jeffrey S. Ross, Sunil Sharma
Oncoscience.2015; 2(3): 285. CrossRef

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