Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
1 "Hyeo Seop Ahn"
Filter
Filter
Article category
Publication year
Authors
Original Article
Clinical Outcome of Relapsed or Refractory Burkitt Lymphoma and Mature B-Cell Lymphoblastic Leukemia in Children and Adolescents
Hyery Kim, Eun Sil Park, Soo Hyun Lee, Hong Hoe Koo, Hyo Sun Kim, Chuhl Joo Lyu, So Eun Jun, Young Tak Lim, Hee Jo Baek, Hoon Kook, Ji Won Lee, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Hyeo Seop Ahn
Cancer Res Treat. 2014;46(4):358-365.   Published online July 21, 2014
DOI: https://doi.org/10.4143/crt.2013.047
AbstractAbstract PDFPubReaderePub
Purpose
Despite the rapid improvement in survival rate from Burkitt lymphoma and mature B-cell lymphoblastic leukemia (B-ALL) in children, a small subset of patients do not respond to first-line chemotherapy or experience relapse (RL). Herein, we report the clinical characteristics and outcomes of these patients.
Materials and Methods
RL or refractory Burkitt lymphoma and mature B-ALL in 125 patients diagnosed from 1990 to 2009 were retrospectively analyzed.
Results
Nineteen patients experienced RL or progressive disease (PD). Among them, 12 patients had PD or RL less than six months after initial treatment and seven had late RL. Seven patients achieved complete response (CR), 11 had PD, and one had no more therapy. Six patients who achieved CR survived without evidence of disease and four of them underwent high-dose chemotherapy (HDC) followed by stem cell transplantation (SCT). However, 11 patients who failed to obtain CR eventually died of their disease. Five-year overall survival (OS) was 31.6±10.7%. OS of patients with late RL was superior to that of patients with early RL (57.1±18.7%, vs. 16.7±10.8%, p=0.014). Achievement of CR after reinduction had significant OS (p < 0.001). OS for patients who were transplanted was superior (p < 0.01). In multivariate analysis, achievement of CR after reinduction chemotherapy showed an association with improved OS (p=0.05).
Conclusion
Late RL and chemotherapy-sensitive patients have the chance to achieve continuous CR using HDC/SCT, whereas patients who are refractory to retrieval therapy have poor prognosis. Therefore, novel salvage strategy is required for improvement of survival for this small set of patients.

Citations

Citations to this article as recorded by  
  • The experience of relapsed Burkitt lymphoma treatment with targeted drugs and autologous/allogeneic stem cell transplantation
    T. T. Valiev, A. A. Khachatryan, S. V. Goryacheva, N. A. Batmanova, K. I. Kirgizov, S. R. Varfolomeeva
    Oncohematology.2024; 19(1): 40.     CrossRef
  • Refractory Burkitt Lymphoma: Diagnosis and Interventional Strategies
    Francesco Malfona, Anna Maria Testi, Sabina Chiaretti, Maria Luisa Moleti
    Blood and Lymphatic Cancer: Targets and Therapy.2024; Volume 14: 1.     CrossRef
  • MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
    Rosa Bordone, Devon Michael Ivy, Rodrigo D’Amico, Martina Barba, Miriam Gaggianesi, Fiorella Di Pastena, Bianca Cesaro, Francesca Bufalieri, Alessio Balzerano, Enrico De Smaele, Giuseppe Giannini, Lucia Di Marcotullio, Alessandro Fatica, Giorgio Stassi, L
    Oncogene.2024; 43(46): 3349.     CrossRef
  • Prognostic Factors and Treatment Outcome of Relapsing and Refractory Pediatric Mature B-cell Non-Hodgkin Lymphoma, Children’s Cancer Hospital Egypt Experience
    Samah F. Semary, Hany Abdel Rahman, Naglaa Elkinaai, Iman Zaky, Nouran Nagy, Sherine Salem, Asmaa Hamoda
    Journal of Pediatric Hematology/Oncology.2023; 45(6): e757.     CrossRef
  • Chronic Recurrent Multifocal Osteomyelitis Associated With Inflammatory Bowel Disease Successfully Treated With Infliximab
    Shinhyeung Kwak, Dongsub Kim, Joon-sik Choi, Yoonsun Yoon, Eun Sil Kim, Mi Jin Kim, So-Young Yoo, Jong Sup Shim, Yon Ho Choe, Yae-Jean Kim
    Pediatric Infection & Vaccine.2022; 29(2): 96.     CrossRef
  • Burkitt lymphoma
    Cristina López, Birgit Burkhardt, John K. C. Chan, Lorenzo Leoncini, Sam M. Mbulaiteye, Martin D. Ogwang, Jackson Orem, Rosemary Rochford, Mark Roschewski, Reiner Siebert
    Nature Reviews Disease Primers.2022;[Epub]     CrossRef
  • Efficacy and Safety of Inotuzumab Ozogamicin (CMC-544) for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma: A Systematic Review and Meta-Analysis
    Xueqian Li, Meng Zhou, Jiaqian Qi, Yue Han
    Clinical Lymphoma Myeloma and Leukemia.2021; 21(3): e227.     CrossRef
  • Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations
    Birgit Burkhardt, Mary Taj, Nathalie Garnier, Veronique Minard-Colin, Volkan Hazar, Karin Mellgren, Tomoo Osumi, Alina Fedorova, Natalia Myakova, Jaime Verdu-Amoros, Mara Andres, Edita Kabickova, Andishe Attarbaschi, Alan Kwok Shing Chiang, Eva Bubanska,
    Cancers.2021; 13(9): 2075.     CrossRef
  • Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells
    Ghazaleh Khalili-Tanha, Meysam Moghbeli
    Cellular & Molecular Biology Letters.2021;[Epub]     CrossRef
  • EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins
    Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura C. A. Galbraith, Chathura D. Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J. Tierney, Andrew I. Bell, Clare Shannon-Lowe, Marco J. Herold, Alan B. Rickinson, Peter M. Colma
    Cell Death & Differentiation.2020; 27(5): 1554.     CrossRef
  • Treatment of relapsed/refractory paediatric aggressive B‐cell non‐Hodgkin lymphoma
    Maria L. Moleti, Anna M. Testi, Robin Foà
    British Journal of Haematology.2020; 189(5): 826.     CrossRef
  • Clinical Characteristics and Treatment Outcomes of Pediatric Patients with Non-Hodgkin Lymphoma in East Asia
    Jin Kyung Suh, Yi-Jin Gao, Jing-Yan Tang, Shiann-Tarng Jou, Dong-Tsamn Lin, Yoshiyuki Takahashi, Seiji Kojima, Ling Jin, Yonghong Zhang, Jong Jin Seo
    Cancer Research and Treatment.2020; 52(2): 359.     CrossRef
  • An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa
    Ernest Musekwa, Zivanai C. Chapanduka, Fatima Bassa, Mariana Kruger
    South African Journal of Oncology.2020;[Epub]     CrossRef
  • Rituximab is highly effective in children and adolescents with Burkitt lymphoma in Risk Groups R2 to R4
    Zijun Zhen, Jia Zhu, Juan Wang, Suying Lu, Feifei Sun, Junting Huang, Xiaofei Sun
    Pediatric Hematology and Oncology.2020; 37(6): 489.     CrossRef
  • Knockdown of lncRNA MCM3AP-AS1 Attenuates Chemoresistance of Burkitt Lymphoma to Doxorubicin Treatment via Targeting the miR-15a/EIF4E Axis


    Chao Guo, Ming Gong, Zhenling Li
    Cancer Management and Research.2020; Volume 12: 5845.     CrossRef
  • Pediatric Aggressive Mature B-Cell Lymphomas, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology
    Kimberly Davies, Matthew Barth, Saro Armenian, Anthony N. Audino, Phillip Barnette, Branko Cuglievan, Hilda Ding, James B. Ford, Paul J. Galardy, Rebecca Gardner, Rabi Hanna, Robert Hayashi, Alexandra E. Kovach, Andrea Judit Machnitz, Kelly W. Maloney, Li
    Journal of the National Comprehensive Cancer Network.2020; 18(8): 1105.     CrossRef
  • Hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory B-cell non-Hodgkin lymphoma
    Naoto Fujita, Ryoji Kobayashi, Yoshiko Atsuta, Fuminori Iwasaki, Junji Suzumiya, Yoji Sasahara, Masami Inoue, Katsuyoshi Koh, Tsukasa Hori, Hiroaki Goto, Tatsuo Ichinohe, Yoshiko Hashii, Koji Kato, Ritsuro Suzuki, Tetsuo Mitsui
    International Journal of Hematology.2019; 109(4): 483.     CrossRef
  • An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence
    Kevin Kalisz, Francesco Alessandrino, Rose Beck, Daniel Smith, Elias Kikano, Nikhil H. Ramaiya, Sree Harsha Tirumani
    Insights into Imaging.2019;[Epub]     CrossRef
  • Unusual lymphoid malignancy and treatment response in two children with Down syndrome
    Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Outcome of relapse in children and adolescents with B‐cell non‐Hodgkin lymphoma and mature acute leukemia: A report from the French LMB study
    Charlotte Rigaud, Anne Auperin, Anne Jourdain, Stephanie Haouy, Marie‐Laure Couec, Nathalie Aladjidi, Virginie Gandemer, Anne Lambliotte, Geneviève Plat, Judith Landman‐Parker, Jean Michon, Thierry Leblanc, Catherine Patte, Veronique Minard‐Colin
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Anti-Tumor Effect of a Novel DOX/GA-CdTe QD was Mediated by Apoptotic and Autophagic Cell Death
    Huaqin Zuo, Fan Wang, Di Zhou, Yi Zhou, Bing Chen, Jian Ouyang, Peipei Xu
    Nano.2017; 12(01): 1750011.     CrossRef
  • Immunotherapy with the trifunctional anti-CD20 × anti-CD3 antibody FBTA05 in a patient with relapsed t(8;14)-positive post-transplant lymphoproliferative disease
    Anna Kieslich, Peter Ruf, Horst Lindhofer, Raynold Buhmann, Angelika Eggert, Patrick Hundsdoerfer
    Leukemia & Lymphoma.2017; 58(8): 1989.     CrossRef
  • Outcomes of adults with relapsed or refractory Burkitt and high‐grade B‐cell leukemia/lymphoma
    Nicholas J. Short, Hagop M. Kantarjian, Heidi Ko, Joseph D. Khoury, Farhad Ravandi, Deborah A. Thomas, Guillermo Garcia‐Manero, Maria Khouri, Jorge E. Cortes, William G. Wierda, Srdan Verstovsek, Zeev Estrov, Alessandra Ferrajoli, Philip A. Thompson, Sher
    American Journal of Hematology.2017;[Epub]     CrossRef
  • 16,062 View
  • 194 Download
  • 23 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP