Cancer Research and Treatment

Review Article

Regulation and Role of EZH2 in Cancer: Hirohito Yamaguchi, Mien-Chie Hung; Cancer Res Treat. 2014;46(3):209-222. Published online July 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.3.209

Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer of zeste homolog 2 (EZH2) is an enzymatic subunit of PRC2, and evidence shows that EZH2 plays an essential role in cancer initiation, development, progression, metastasis, and drug resistance. EZH2 expression is indeed regulated by various oncogenic transcription factors, tumor suppressor miRNAs, and cancer-associated non-coding RNA. EZH2 activity is also controlled by post-translational modifications, which are deregulated in cancer. The canonical role of EZH2 is gene silencing through H3K27me3, but accumulating evidence shows that EZH2 methlyates substrates other than histone and has methylase-independent functions. These non-canonical functions of EZH2 are shown to play a role in cancer progression. In this review, we summarize current information on the regulation and roles of EZH2 in cancer. We also discuss various therapeutic approaches to targeting EZH2.

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LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression
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Cancer Biomarkers.2020; 18(1): 95. CrossRef
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The Journal of Pathology.2020; 250(1): 79. CrossRef
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Shira Yomtoubian, Sharrell B. Lee, Akanksha Verma, Franco Izzo, Geoffrey Markowitz, Hyejin Choi, Leandro Cerchietti, Linda Vahdat, Kristy A. Brown, Eleni Andreopoulou, Olivier Elemento, Jenny Chang, Giorgio Inghirami, Dingcheng Gao, Seongho Ryu, Vivek Mit
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HOXC10 promotes cell migration, invasion, and tumor growth in gastric carcinoma cells through upregulating proinflammatory cytokines
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Journal of Cellular Physiology.2020; 235(4): 3579. CrossRef
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Lina Li, Jian Liu, Hongsheng Xue, Chunxiao Li, Qun Liu, Yantong Zhou, Ting Wang, Haijuan Wang, Haili Qian, Tao Wen
Oncogene.2020; 39(10): 2125. CrossRef
Network-Based Genetic Profiling Reveals Cellular Pathway Differences Between Follicular Thyroid Carcinoma and Follicular Thyroid Adenoma
Md. Ali Hossain, Tania Akter Asa, Md. Mijanur Rahman, Shahadat Uddin, Ahmed A. Moustafa, Julian M. W. Quinn, Mohammad Ali Moni
International Journal of Environmental Research and Public Health.2020; 17(4): 1373. CrossRef
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Avinash Khanna, Alexandre Côté, Shilpi Arora, Ludivine Moine, Victor S. Gehling, Jehrod Brenneman, Nico Cantone, Jacob I. Stuckey, Shruti Apte, Ashwin Ramakrishnan, Kamil Bruderek, William D. Bradley, James E. Audia, Richard T. Cummings, Robert J. Sims, P
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Cancer Stem Cell Plasticity – A Deadly Deal
Archana P. Thankamony, Kritika Saxena, Reshma Murali, Mohit Kumar Jolly, Radhika Nair
Frontiers in Molecular Biosciences.2020;[Epub] CrossRef
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model
Chidimma Agatha Akpa, Karsten Kleo, Elisabeth Oker, Nancy Tomaszewski, Clemens Messerschmidt, Cristina López, Rabea Wagener, Kathrin Oehl-Huber, Katja Dettmer, Anne Schoeler, Dido Lenze, Peter J. Oefner, Dieter Beule, Reiner Siebert, David Capper, Lora Di
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Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression
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Cancer Science.2020; 111(7): 2297. CrossRef
CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation
Si-Qi Wang, Jing Liu, Jing Qin, Yun Zhu, Vicky Pui-Chi Tin, Judy Wai Ping Yam, Maria Pik Wong, Zhi-Jie Xiao
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INI-1 (SMARCB1)–Deficient Undifferentiated Sinonasal Carcinoma: Novel Paradigm of Molecular Testing in the Diagnosis and Management of Sinonasal Malignancies
Khvaramze Shaverdashvili, Elham Azimi-Nekoo, Perry Cohen, Nadeem Akbar, Thomas J. Ow, Balazs Halmos, Enrico Castellucci
The Oncologist.2020; 25(9): 738. CrossRef
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Nazli Dizman, Errol J. Philip, Sumanta K. Pal
Nature Reviews Nephrology.2020; 16(8): 435. CrossRef
The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta
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Epigenomes.2020; 4(3): 20. CrossRef
FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway
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Journal of Cellular and Molecular Medicine.2020; 24(20): 11858. CrossRef
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Asad Ur Rehman, Mohammad Askandar Iqbal, Real Sumayya Abdul Sattar, Snigdha Saikia, Mohammad Kashif, Wasif Mohammad Ali, Subhash Medhi, Sundeep Singh Saluja, Syed Akhtar Husain
Cancer Cell International.2020;[Epub] CrossRef
MicroRNA-33b Suppresses Epithelial–Mesenchymal Transition Repressing the MYC–EZH2 Pathway in HER2+ Breast Carcinoma
Birlipta Pattanayak, Iris Garrido-Cano, Anna Adam-Artigues, Eduardo Tormo, Begoña Pineda, Paula Cabello, Elisa Alonso, Begoña Bermejo, Cristina Hernando, María Teresa Martínez, Ana Rovira, Joan Albanell, Federico Rojo, Octavio Burgués, Juan Miguel Cejalvo
Frontiers in Oncology.2020;[Epub] CrossRef
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Steroids.2020; 164: 108729. CrossRef
EZH2 overexpression dampens tumor-suppressive signals via an EGR1 silencer to drive breast tumorigenesis
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Oncogene.2020; 39(48): 7127. CrossRef
RETRACTED: Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter
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Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
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The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer
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Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer
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Molecular Cancer Therapeutics.2020; 19(12): 2490. CrossRef
Aberrant differential expression of EZH2 and H3K27me3 in extranodal NK/T-cell lymphoma, nasal type, is associated with disease progression and prognosis
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Retracted: Long noncoding RNA TALNEC2 plays an oncogenic role in breast cancer by binding to EZH2 to target p57KIP2 and involving in p‐p38 MAPK and NF‐κB pathways
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Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells
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Cell Biology and Toxicology.2019; 35(4): 361. CrossRef
lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer
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LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis
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Biomedicine & Pharmacotherapy.2019; 112: 108719. CrossRef
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iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?
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Protein dynamics analysis reveals that missense mutations in cancer‐related genes appear frequently on hinge‐neighboring residues
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Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity
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Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets
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Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
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Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma
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EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia
Subazini Thankaswamy Kosalai, Mohammad Hamdy Abdelrazak Morsy, Nikos Papakonstantinou, Larry Mansouri, Niki Stavroyianni, Chandrasekhar Kanduri, Kostas Stamatopoulos, Richard Rosenquist, Meena Kanduri
Epigenetics.2019; 14(11): 1125. CrossRef
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DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations
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HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia
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Aberrant Expression of EZH2 in Pediatric Patients with Myelodysplastic Syndrome: A Potential Biomarker of Leukemic Evolution
Teresa de Souza Fernandez, Tatiana Fonseca Alvarenga, Elaiza Almeida Antônio de Kós, Viviane Lamim Lovatel, Rita de Cássia Tavares, Elaine Sobral da Costa, Cecília de Souza Fernandez, Eliana Abdelhay
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Pei-Pei Kung, Patrick Bingham, Alexei Brooun, Michael Collins, Ya-Li Deng, Dac Dinh, Connie Fan, Ketan S. Gajiwala, Rita Grantner, Hovhannes J. Gukasyan, Wenyue Hu, Buwen Huang, Robert Kania, Susan E. Kephart, Cody Krivacic, Robert A. Kumpf, Penney Khamph
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Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA
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Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells
Zahre Sajadpoor, Zeinab Amini-Farsani, Hossein Teimori, Mehdi Shamsara, Mohammad Hossein Sangtarash, Payam Ghasemi-Dehkordi, Farrokh Yadollahi
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Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas
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The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma
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Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer
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EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer
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Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells
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Anti-tumor and anti-metastasis activities of honey bee larvae powder by suppressing the expression of EZH2
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Biomedicine & Pharmacotherapy.2018; 105: 690. CrossRef
Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma
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EBioMedicine.2018; 37: 177. CrossRef
DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2
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Cancer Communications.2018; 38(1): 1. CrossRef
EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
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Long Noncoding RNA ANRIL Supports Proliferation of Adult T-Cell Leukemia Cells through Cooperation with EZH2
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MET/ERK and MET/JNK Pathway Activation Is Involved in BCR-ABL Inhibitor-resistance in Chronic Myeloid Leukemia
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EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes
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Oncotarget.2018; 9(31): 21930. CrossRef
The untold stories of the speech gene, the FOXP2 cancer gene
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Genes & Cancer.2018; 9(1-2): 11. CrossRef
SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer
W Lu, S Liu, B Li, Y Xie, M G Izban, B R Ballard, S A Sathyanarayana, S E Adunyah, R J Matusik, Z Chen
Oncogene.2017; 36(10): 1364. CrossRef
Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis
Junchao Xue, Yang Liu, Fei Luo, Xiaolin Lu, Hui Xu, Xinlu Liu, Lu Lu, Qianlei Yang, Chao Chen, Weimin Fan, Qizhan Liu
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Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
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Modulation of HAT activity by the BRCA2 N372H variation is a novel mechanism of paclitaxel resistance in breast cancer cell lines
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Biochemical Pharmacology.2017; 138: 163. CrossRef
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Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options
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The American Journal of Pathology.2017; 187(10): 2288. CrossRef
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Laura Vilorio-Marqués, Vicente Martín, Cristina Diez-Tascón, María Francisca González-Sevilla, Tania Fernández-Villa, Emiliano Honrado, Veronica Davila-Batista, Antonio J. Molina
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Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy
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Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells
Masanobu Tsubaki, Tomoya Takeda, Toshiki Kino, Kazuko Sakai, Tatsuki Itoh, Motohiro Imano, Takashi Nakayama, Kazuto Nishio, Takao Satou, Shozo Nishida
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Methylation-mediated silencing of microRNA-211 promotes cell growth and epithelial to mesenchymal transition through activation of the AKT/β-catenin pathway in GBM
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EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis
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Inhibition of enhancer of zeste homolog 2 increases the expression of p16 and suppresses the proliferation and migration of ovarian carcinoma cells inï¿½vitro and inï¿½vivo
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miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer
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TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis
Min Deng, Ruixin Zhang, Zhengxi He, Qinwei Qiu, Xihong Lu, Jiang Yin, Hao Liu, Xiaoting Jia, Zhimin He
Cancer Research.2017; 77(22): 6069. CrossRef
The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications
Soo Hee Kim, Woo Ick Yang, Yoo Hong Min, Young Hyeh Ko, Sun Och Yoon
Tumor Biology.2016; 37(2): 2037. CrossRef
Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression
Liqiong Cai, Zehua Wang, Denghua Liu
Tumor Biology.2016; 37(5): 6359. CrossRef
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane
Matthew L. Fisher, Gautam Adhikary, Dan Grun, David M. Kaetzel, Richard L. Eckert
Molecular Carcinogenesis.2016; 55(12): 2024. CrossRef
Problems of glioblastoma multiforme drug resistance
A. A. Stavrovskaya, S. S. Shushanov, E. Yu. Rybalkina
Biochemistry (Moscow).2016; 81(2): 91. CrossRef
High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
Si-Hyong Jang, Jong Eun Lee, Mee-Hye Oh, Ji-Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee
Journal of Breast Cancer.2016; 19(1): 53. CrossRef
Expression of Mirna-26B in the Diagnosis and Prognosis of Patients with Non-Small-Cell Lung Cancer
Li-Peng Jiang, Zhi-Tu Zhu, Chun-Yan He
Future Oncology.2016; 12(9): 1105. CrossRef
Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches
Sebastian Carotta
Frontiers in Immunology.2016;[Epub] CrossRef
Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
Fade Mahmoud, Bradley Shields, Issam Makhoul, Laura F. Hutchins, Sara C. Shalin, Alan J. Tackett
Cancer Biology & Therapy.2016; 17(6): 579. CrossRef
Prognostic value of UTX expression in patients with clear cell renal cell carcinoma
Jiajun Wang, Li Liu, Wei Xi, Qilai Long, Yiwei Wang, Qi Bai, Yu Xia, Jiejie Xu, Jianming Guo
Urologic Oncology: Seminars and Original Investigations.2016; 34(8): 338.e19. CrossRef
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics
G. Paolo Dotto, Anil K. Rustgi
Cancer Cell.2016; 29(5): 622. CrossRef
Genomic and Epigenomic Alterations in Cancer
Balabhadrapatruni V.S.K. Chakravarthi, Saroj Nepal, Sooryanarayana Varambally
The American Journal of Pathology.2016; 186(7): 1724. CrossRef
Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma
Yusuke Furukawa, Jiro Kikuchi
International Journal of Hematology.2016; 104(3): 281. CrossRef
Down-Regulation of TSLP After EZH2 Silencing in ESCC Cell Line
Gholamreza Karami Madani, Abolfazl Rad, Mohammad Mahdi Forghanifard
Journal of Biomedicine.2016;[Epub] CrossRef
High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas
Maria Ramaglia, Velia D’Angelo, Adriana Iannotta, Daniela Di Pinto, Elvira Pota, Maria Carmen Affinita, Vittoria Donofrio, Maria Elena Errico, Angela Lombardi, Cristiana Indolfi, Fiorina Casale, Michele Caraglia
Cancer Cell International.2016;[Epub] CrossRef
DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity
Y Wang, H Sun, J Wang, H Wang, L Meng, C Xu, M Jin, B Wang, Y Zhang, Y Zhang, T Zhu
Cell Death & Disease.2016; 7(7): e2316. CrossRef
Significance of EZH2 expression in canine mammary tumors
Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong, Woo-Chan Son
BMC Veterinary Research.2016;[Epub] CrossRef
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl
Rishi G. Vaswani, Victor S. Gehling, Les A. Dakin, Andrew S. Cook, Christopher G. Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Srividya Balasubramanian, Feng Zhao, Andrew C. Good, Robert Campbell, Christina Lee, Nico Cantone, Richard T. Cummings, Emm
Journal of Medicinal Chemistry.2016; 59(21): 9928. CrossRef
MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells
Hongrui Wang, Yake Meng, Quanjun Cui, Fujun Qin, Haisong Yang, Yu Chen, Yajun Cheng, Jiangang Shi, Yongfei Guo
Scientific Reports.2016;[Epub] CrossRef
EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells
Ming-Quan Sha, Xiao-Li Zhao, Liang Li, Li-Hui Li, Yi Li, Tian-Geng Dong, Wei-Xin Niu, Li-Jun Jia, Rong-Guang Shao, Yong-Su Zhen, Zhen Wang
Cell Death & Disease.2016; 7(11): e2486. CrossRef
Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report
Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik, Agata M. Bogusz
Diagnostic Pathology.2016;[Epub] CrossRef
Expression Profile and Function Analysis of LncRNAs during Priming Phase of Rat Liver Regeneration
Jun Li, Wei Jin, Yanli Qin, Weiming Zhao, Cuifang Chang, Cunshuan Xu, Klaus Roemer
PLOS ONE.2016; 11(6): e0156128. CrossRef
Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer
Cortney L. Lawrence, Albert S. Baldwin, Aamir Ahmad
PLOS ONE.2016; 11(10): e0165005. CrossRef
Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids
Qiwei Yang, Archana Laknaur, Lelyand Elam, Nahed Ismail, Larisa Gavrilova-Jordan, John Lue, Michael P. Diamond, Ayman Al-Hendy
Reproductive Sciences.2016; 23(10): 1314. CrossRef
The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway
Hiroyoshi Kurihara, Reo Maruyama, Kazuya Ishiguro, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Kei Mitsuhashi, Hisayoshi Igarashi, Miki Ito, Tokuma Tanuma, Yasutaka Sukawa, Kenji Okita, Tadashi Hasegawa, Kohzoh Imai, Hiroyuki Yamamoto, Yasuhisa Shin
Oncotarget.2016; 7(11): 12704. CrossRef
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagno
Oncotarget.2016; 7(24): 35946. CrossRef
Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells
Lydia Edjekouane, Samira Benhadjeba, Maïka Jangal, Hubert Fleury, Nicolas Gévry, Euridice Carmona, André Tremblay
Oncotarget.2016; 7(47): 77276. CrossRef
Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential
Ranran Sun, Jacson Shen, Yan Gao, Yubing Zhou, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan
Oncotarget.2016; 7(25): 38333. CrossRef
GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers
How-Wen Ko, Heng-Huan Lee, Longfei Huo, Weiya Xia, Cheng-Chieh Yang, Jennifer L. Hsu, Long-Yuan Li, Chien-Chen Lai, Li-Chuan Chan, Chien-Chia Cheng, Adam M. Labaff, Hsin-Wei Liao, Seung-Oe Lim, Chia-Wei Li, Yongkun Wei, Lei Nie, Hirohito Yamaguchi, Mien-C
Oncotarget.2016; 7(35): 57131. CrossRef
Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma
Youtao Xu, Jie Wang, Mantang Qiu, Lei Xu, Ming Li, Feng Jiang, Rong Yin, Lin Xu
Tumor Biology.2015; 36(3): 1643. CrossRef
Role of the ubiquitin proteasome system in hematologic malignancies
Anagh A. Sahasrabuddhe, Kojo S. J. Elenitoba‐Johnson
Immunological Reviews.2015; 263(1): 224. CrossRef
The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer
Lili Liao, Joseph R. Testa, Haifeng Yang
Cancer Genetics.2015; 208(5): 206. CrossRef
The role of aberrant proteolysis in lymphomagenesis
Anagh A. Sahasrabuddhe, Kojo S.J. Elenitoba-Johnson
Current Opinion in Hematology.2015; 22(4): 369. CrossRef
Small Molecule Inhibitors of EZH2: the Emerging Translational Landscape
Heike Keilhack, Jesse J Smith
Epigenomics.2015; 7(3): 337. CrossRef
Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma
Yang-Fan Lv, Guang-Ning Yan, Gang Meng, Xi Zhang, Qiao-Nan Guo
Scientific Reports.2015;[Epub] CrossRef
Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma
Mehnaz Khan, Laura L Walters, Qiang Li, Dafydd G Thomas, Jason M L Miller, Qitao Zhang, Andrew P Sciallis, Yu Liu, Brian J Dlouhy, Patrice E Fort, Steven M Archer, Hakan Demirci, Yali Dou, Rajesh C Rao
Laboratory Investigation.2015; 95(11): 1278. CrossRef
Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer
Emmi I. Joensuu, Taina T. Nieminen, Johanna E. Lotsari, Walter Pavicic, Wael M. Abdel‐Rahman, Päivi Peltomäki
Genes, Chromosomes and Cancer.2015; 54(12): 776. CrossRef
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma
Jiro Kikuchi, Daisuke Koyama, Taeko Wada, Tohru Izumi, Peter O. Hofgaard, Bjarne Bogen, Yusuke Furukawa
Journal of Clinical Investigation.2015; 125(12): 4375. CrossRef
Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters
Nathaniel Melling, Erik Thomsen, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Ste
Carcinogenesis.2015; 36(11): 1333. CrossRef
EZH2 in Bladder Cancer, a Promising Therapeutic Target
Mónica Martínez-Fernández, Carolina Rubio, Cristina Segovia, Fernando López-Calderón, Marta Dueñas, Jesús Paramio
International Journal of Molecular Sciences.2015; 16(11): 27107. CrossRef
siRNA Silencing EZH2 Reverses Cisplatin-resistance of Human Non-small Cell Lung and Gastric Cancer Cells
Wen Zhou, Jian Wang, Wang-Ying Man, Qing-Wei Zhang, Wen-Gui Xu
Asian Pacific Journal of Cancer Prevention.2015; 16(6): 2425. CrossRef
H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis
Mariano Colón-Caraballo, Janice B. Monteiro, Idhaliz Flores
Reproductive Sciences.2015; 22(9): 1134. CrossRef
A Gene Regulatory Program in Human Breast Cancer
Renhua Li, John Campos, Joji Iida
Genetics.2015; 201(4): 1341. CrossRef
MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells
Xiaoping Liu, Qianqian Lei, Zhibin Yu, Gang Xu, Hailin Tang, Wei Wang, Zeyou Wang, Guiyuan Li, Minghua Wu
Oncotarget.2015; 6(10): 7930. CrossRef
Enhancer of zeste acts as a major developmental regulator ofCiona intestinalisembryogenesis
Emilie Le Goff, Camille Martinand-Mari, Marianne Martin, Jérôme Feuillard, Yvan Boublik, Nelly Godefroy, Paul Mangeat, Stephen Baghdiguian, Giacomo Cavalli
Biology Open.2015; 4(9): 1109. CrossRef

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