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Original Articles
- CNS cancer
- Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)
- Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
- Cancer Res Treat. 2022;54(2):396-405. Published online July 6, 2021
- DOI: https://doi.org/10.4143/crt.2021.393
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Abstract
PDF
Supplementary Material
PubReader
ePub - Purpose
The KNOG-1101 study showed improved 2-year PFS with temozolomide during and after radiotherapy compared to radiotherapy alone for patients with anaplastic gliomas. This trial investigates the effect of concurrent and adjuvant temozolomide on health-related quality of life (HRQoL).
Materials and Methods
In this randomized, open-label, phase II trial, 90 patients with World Health Organization grade III glioma were enrolled across multiple centers in South Korea between March 2012 to February 2015 and followed up through 2017. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and 20-item EORTC QLQ-Brain Neoplasm (QLQ-BN20) were used to compare HRQoL between patients assigned to concurrent chemoradiotherapy with temozolomide followed by 6 cycles of adjuvant temozolomide (arm A) and radiotherapy (RT) alone (arm B).
Results
Of the 90 patients in the study, 84 patients (93.3%) completed the baseline HRQoL questionnaire. Emotional functioning, fatigue, nausea and vomiting, dyspnea, constipation, appetite loss, diarrhea, seizures, itchy skin, drowsiness, hair loss, and bladder control were not affected by the addition of temozolomide. All other items did not differ significantly between arm A and arm B throughout treatment. Global health status particularly stayed consistent at the end of adjuvant temozolomide (p=0.47) and at the end of RT (p=0.33).
Conclusion
The addition of concurrent and adjuvant temozolomide did not show negative influence on HRQoL with improvement of progression-free survival for patients with anaplastic gliomas. The absence of systematic and clinically relevant changes in HRQoL suggests that an overall long-term net clinical benefit exists for concurrent and adjuvant temozolomide. -
Citations
Citations to this article as recorded by
- Achievements of international rare cancers networks and consortia in the neuro-oncology field
Vincenzo Di Nunno, Enrico Franceschi, Ahmed Idbaih
Current Opinion in Oncology.2024; 36(6): 554. CrossRef - Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review
Jason A. Martin, Nicolas H. Hart, Natalie Bradford, Fiona Naumann, Mark B. Pinkham, Elizabeth P. Pinkham, Justin J. Holland
Journal of Neuro-Oncology.2023; 162(1): 25. CrossRef - Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats
Anastasia Strokotova, Dmitry Sokolov, Olga Molodykh, Elena Koldysheva, Evgenii Kliver, Victor Ushakov, Maxim Politko, Nadezhda Mikhnevich, Galina Kazanskaya, Svetlana Aidagulova, Elvira Grigorieva
Biomedical Reports.2023;[Epub] CrossRef
- Achievements of international rare cancers networks and consortia in the neuro-oncology field
- 8,356 View
- 164 Download
- 4 Web of Science
- 3 Crossref
- Central nervous system
- A Nationwide, Population-Based Epidemiology Study of Primary Central Nervous System Tumors in Korea, 2007-2016: A Comparison with United States Data
- Ho Kang, Sang Woo Song, Johyun Ha, Young-Joo Won, Chul-Kee Park, Heon Yoo, Kyu-Won Jung
- Cancer Res Treat. 2021;53(2):355-366. Published online October 7, 2020
- DOI: https://doi.org/10.4143/crt.2020.847
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to determine the epidemiologic characteristics and survival of patients with primary brain and other central nervous system (CNS) tumors in Korea and to compare our findings with those from the United States.
Materials and Methods
We collected data on primary brain and CNS tumors diagnosed between 2007 and 2016 from the Korea Central Cancer Registry. The age-standardized incidence rates (ASRs) and 5-year relative survival rates (RSRs) were evaluated. We applied the classification and definitions of the Central Brain Tumor Registry of the United States to our analysis for direct comparison with United States data.
Results
A total of 115,050 primary brain and CNS tumors were identified, and the ASR of all tumors was 22.01 per 100,000 individuals, which was lower than the 23.41 in the United States. However, the ASR of malignant tumors was significantly lower herein (4.27) than in the United States (7.08). Meningeal tumors were the most common histologic group among all tumors (ASR, 8.32). The 5-year RSR of all primary brain and other CNS tumors was 86.4%, and that of all malignant tumors was 44.1%, which was higher than the 35.8% observed in the United States. Among malignant tumors, glioblastomas had the lowest 5-year RSR (12.1%).
Conclusion
In Korea, malignant brain and other CNS tumors have a lower incidence and better survival outcome. -
Citations
Citations to this article as recorded by- Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database
Yong Kyun Won, Eun Seog Kim, In Young Jo, Hyuk-jin Oh, Sang Mi Lee, Ik Dong Yoo, Sun-pyo Hong, Jeong Won Lee, Jin Ho Song, Nayoon Kang, Hong Seok Jang
Journal of Neuro-Oncology.2025; 171(2): 463. CrossRef - 18F-FET PET/CT can aid in diagnosing patients with indeterminate MRI findings for brain tumors: a prospective study
Sheng-Chieh Chan, Tsung-Lang Chiu, Shu-Hang Ng, Hung-Wen Kao, Sheng-Tzung Tsai, Shu-Hsin Liu
Annals of Nuclear Medicine.2025; 39(4): 342. CrossRef - Management and survival trends for diffuse gliomas diagnosed at a single neurooncology center in China during 2000 to 2020
Depei Li, Yinsheng Chen, Tang-Fai Wong, Qunying Yang, ChengCheng Guo, Xiaobing Jiang, Chao Ke, Xiangheng Zhang, Jing Zeng, Yanchun Lv, Shaoxiong Wu, Jian Wang, Ke Sai, Yonggao Mou, Zhongping Chen
Scientific Reports.2025;[Epub] CrossRef - The Natural History and Treatment of Meningiomas: An Update
Arsene Daniel Nyalundja, Fabrice Mugisha, Claire Karekezi
Seminars in Neurology.2024; 44(01): 001. CrossRef - Gamma knife radiosurgery as primary management for intracranial meningioma identified as growing on serial imaging
Yeong Jin Kim, Kyung-Sub Moon, Sue Jee Park, Tae-Young Jung, In-Young Kim, Shin Jung
Medicine.2024; 103(5): e37082. CrossRef - Changes in the Epidemiologic Pattern of Primary CNS Tumors in Response to the Aging Population: An Updated Nationwide Cancer Registry Data in the Republic of Korea
Yoon Hwan Byun, Johyun Ha, Ho Kang, Chul-Kee Park, Kyu-Won Jung, Heon Yoo
JCO Global Oncology.2024;[Epub] CrossRef - Surgical indications and outcomes of the endoscopic endonasal approach for brain tumors in older adults in Korea: a retrospective study
Sun Mo Nam, Yoon Hwan Byun, Jung Hee Kim, Min-Sung Kim, Chul-Kee Park, Yong Hwy Kim
Journal of Korean Society of Geriatric Neurosurgery.2024; 20(1): 21. CrossRef - Bevacizumab Alone Versus Bevacizumab Plus Irinotecan in Patients With Recurrent Glioblastoma: A Nationwide Population-Based Study
Yeonhu Lee, Eunyoung Lee, Tae Hoon Roh, Se-Hyuk Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef - Survival After Newly-Diagnosed High-Grade Glioma Surgery: What Can We Learn From the French National Healthcare Database?
Charles Champeaux Depond, Luc Bauchet, Dahmane Elhairech, Philippe Tuppin, Vincent Jecko, Joconde Weller, Philippe Metellus
Brain Tumor Research and Treatment.2024; 12(3): 162. CrossRef - Optimal timing of chemoradiation after resection or biopsy of glioblastomas: a nationwide population-based study
Dongeun Lee, Eunyoung Lee, Tae Hoon Roh, Se-Hyuk Kim
BMC Cancer.2024;[Epub] CrossRef - Association between insomnia disorder and mortality among patients who underwent craniotomy for brain tumor resection: a South Korean nationwide cohort study
Hey-ran Choi, In-Ae Song, Hye Yoon Park, Tak Kyu Oh
Sleep and Breathing.2023; 27(1): 329. CrossRef - Fully Automated MRI Segmentation and Volumetric Measurement of Intracranial Meningioma Using Deep Learning
Ho Kang, Joseph Nathanael Witanto, Kevin Pratama, Doohee Lee, Kyu Sung Choi, Seung Hong Choi, Kyung‐Min Kim, Min‐Sung Kim, Jin Wook Kim, Yong Hwy Kim, Sang Joon Park, Chul‐Kee Park
Journal of Magnetic Resonance Imaging.2023; 57(3): 871. CrossRef - Patterns of care and survival of Chinese glioblastoma patients in the temozolomide era: a Hong Kong population-level analysis over a 14-year period
Peter Y M Woo, Stephen Yau, Tai-Chung Lam, Jenny K S Pu, Lai-Fung Li, Louisa C Y Lui, Danny T M Chan, Herbert H F Loong, Michael W Y Lee, Rebecca Yeung, Carol C H Kwok, Siu-Kie Au, Tze-Ching Tan, Amanda N C Kan, Tony K T Chan, Calvin H K Mak, Henry K F Ma
Neuro-Oncology Practice.2023; 10(1): 50. CrossRef - Paths of Evolution of Progressive Anaplastic Meningiomas: A Clinical and Molecular Pathology Study
Rina Di Bonaventura, Liverana Lauretti, Maurizio Martini, Tonia Cenci, Giuliano Di Monaco, Davide Palombi, Giovanni Maria Ceccarelli, Silvia Chiesa, Marco Gessi, Alessia Granitto, Alessio Albanese, Luigi Maria Larocca, Quintino Giorgio D’Alessandris, Robe
Journal of Personalized Medicine.2023; 13(2): 206. CrossRef - Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore
Current Oncology Reports.2023; 25(7): 765. CrossRef - Decreased income, unemployment, and disability after craniotomy for brain tumor removal: a South Korean nationwide cohort study
Tak Kyu Oh, In-Ae Song, Ji-Eyon Kwon, Solyi Lee, Hey-Ran Choi, Young-Tae Jeon
Supportive Care in Cancer.2022; 30(2): 1663. CrossRef - Association between surgical volume and outcomes after craniotomy for brain tumor removal: A South Korean nationwide cohort study
Hey-ran Choi, In-Ae Song, Tak Kyu Oh
Journal of Clinical Neuroscience.2022; 100: 75. CrossRef - The comparative burden of brain and central nervous system cancers from 1990 to 2019 between China and the United States and predicting the future burden
Jiajia Huang, Hanmei Li, Hualing Yan, Fen-Xiang Li, Mai Tang, Da-Lin Lu
Frontiers in Public Health.2022;[Epub] CrossRef - Anaplastic Meningioma: Clinical Characteristics, Prognostic Factors and Survival Outcome
Dong Ok Seo, Sang Woo Song, Young-Hoon Kim, Chang-Ki Hong, Jeong Hoon Kim
Brain Tumor Research and Treatment.2022; 10(4): 244. CrossRef - Classification and Diagnosis of Adult Glioma: A Scoping Review
Yoon Hwan Byun, Chul-Kee Park
Brain & Neurorehabilitation.2022;[Epub] CrossRef - The epidemiology series of brain-related disorders in Mongolia: nationwide registry-based epidemiological study on CNS tumours in Mongolia, 2015–2019
Tuvshingerel Sandagdorj, Undarmaa Tudev, Otgonbold Jamiyandorj, Takakazu Oka, Battuvshin Lkhagvasuren
Journal of Integrative Neuroscience.2022;[Epub] CrossRef - Depression and mortality after craniotomy for brain tumor removal: A Nationwide cohort study in South Korea
Tak Kyu Oh, In-Ae Song, Hye Yoon Park, Young-Tae Jeon
Journal of Affective Disorders.2021; 295: 291. CrossRef
- Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database
- 8,661 View
- 216 Download
- 22 Crossref
- Concurrent and Adjuvant Temozolomide for Newly Diagnosed Grade III Gliomas without 1p/19q Co-deletion: A Randomized, Open-Label, Phase 2 Study (KNOG-1101 Study)
- Kihwan Hwang, Tae Min Kim, Chul-Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
- Cancer Res Treat. 2020;52(2):505-515. Published online October 28, 2019
- DOI: https://doi.org/10.4143/crt.2019.421
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Abstract
PDFPubReaderePub
- Purpose
We investigated the efficacy of temozolomide during and after radiotherapy in Korean adults with anaplastic gliomas without 1p/19q co-deletion.
Materials and Methods
This was a randomized, open-label, phase 2 study and notably the first multicenter trial for Korean grade III glioma patients. Eligible patients were aged 18 years or older and had newly diagnosed non-co-deleted anaplastic glioma with an Eastern Cooperative Oncology Group performance status of 0-2. Patients were randomized 1:1 to receive radiotherapy alone (60 Gy in 30 fractions of 2 Gy) (control group, n=44) or to receive radiotherapy with concurrent temozolomide (75 mg/m2/day) followed by adjuvant temozolomide (150-200 mg/m2/day for 5 days during six 28-day cycles) (treatment group, n=40). The primary end-point was 2-year progression-free survival (PFS). Seventy patients (83.3%) were available for the analysis of the isocitrate dehydrogenase 1 gene (IDH1) mutation status.
Results
The two-year PFS was 42.2% in the treatment group and 37.2% in the control group. Overall survival (OS) did not reach to significant difference between the groups. In multivariable analysis, age was a significant risk factor for PFS (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.04 to 4.16). The IDH1 mutation was the only significant prognostic factor for PFS (HR, 0.28; 95% CI, 0.13 to 0.59) and OS (HR, 0.19; 95% CI, 0.07 to 0.50). Adverse events over grade 3 were seen in 16 patients (40.0%) in the treatment group and were reversible.
Conclusion
Concurrent and adjuvant temozolomide in Korean adults with newly diagnosed non-co- deleted anaplastic gliomas showed improved 2-year PFS. The survival benefit of this regimen needs further analysis with long-term follow-up at least more than 10 years. -
Citations
Citations to this article as recorded by- Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
Jordina Rincon-Torroella, Maureen Rakovec, Anita L. Kalluri, Kelly Jiang, Carly Weber-Levine, Megan Parker, Divyaansh Raj, Josh Materi, Sadra Sepehri, Abel Ferres, Karisa C. Schreck, Iban Aldecoa, Calixto-Hope G. Lucas, Haris I. Sair, Kristin J. Redmond,
Journal of Neuro-Oncology.2025; 171(1): 35. CrossRef - Multidisciplinary Management of Isocitrate Dehydrogenase–Mutated Gliomas in a Contemporary Molecularly Defined Era
Rupesh Kotecha, David Schiff, Arnab Chakravarti, Jessica L. Fleming, Paul D. Brown, Vinay K. Puduvalli, Michael A. Vogelbaum, Vinai Gondi, Marco Gallus, Hideho Okada, Minesh P. Mehta
Journal of Clinical Oncology.2024; 42(21): 2588. CrossRef - The IDH paradox: Meta-analysis of alkylating chemotherapy in IDH-wild type and -mutant lower grade gliomas
Connor J Kinslow, Soumyajit Roy, Fabio M Iwamoto, Paul D Brown, David M DeStephano, Peter D Canoll, Summer S Qureshi, Matthew Gallito, Michael B Sisti, Jeffrey N Bruce, David P Horowitz, Lisa A Kachnic, Alfred I Neugut, James B Yu, Minesh P Mehta, Simon K
Neuro-Oncology.2024; 26(10): 1839. CrossRef - The Role of Systemic Therapies in the Treatment of Grades 1-4 Gliomas
Jan Stepka, Mariusz Dotka, Maciej Kosiński, Piotr Suchecki, Maciej Hobot, Igor Piotrowski
Cureus.2024;[Epub] CrossRef - Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline
Nimish A. Mohile, Hans Messersmith, Na Tosha Gatson, Andreas F. Hottinger, Andrew Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A. Shih, Roy Strowd, M
Journal of Clinical Oncology.2022; 40(4): 403. CrossRef - Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline
Nimish A Mohile, Hans Messersmith, Na Tosha N Gatson, Andreas F Hottinger, Andrew B Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A Shih, Roy Strowd,
Neuro-Oncology.2022; 24(3): 358. CrossRef - Executive summary of American Radium Society’s appropriate use criteria for the postoperative management of lower grade gliomas
Martin C. Tom, Michael T. Milano, Samuel T. Chao, Scott G. Soltys, Jonathan P.S. Knisely, Arjun Sahgal, Seema Nagpal, Simon S. Lo, Siavash Jabbari, Tony J.C. Wang, Manmeet S. Ahluwalia, Marian Simonson, Joshua D. Palmer, Melanie Hayden Gephart, Lia M. Hal
Radiotherapy and Oncology.2022; 170: 79. CrossRef - Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)
Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeo
Cancer Research and Treatment.2022; 54(2): 396. CrossRef - The Risk of Heart Disease-Related Death Among Anaplastic Astrocytoma Patients After Chemotherapy: A SEER Population-Based Analysis
Qi Lin, Jia-Hao Bao, Fei Xue, Jia-Jun Qin, Zhen Chen, Zhong-Rong Chen, Chao Li, Yi-Xuan Yan, Jin Fu, Zhao-Li Shen, Xian-Zhen Chen
Frontiers in Oncology.2022;[Epub] CrossRef - Association between a prior cancer history and prognosis in adult patients with high‑grade glioma
Dongjie He, Peiwen Wu, Gaiyan Li, Siying Zhu, Qiming Wang, Qiuju Shao, Hao Chang
Journal of Clinical Neuroscience.2022; 106: 20. CrossRef
- Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
- 9,883 View
- 635 Download
- 10 Web of Science
- 10 Crossref
- Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
- Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won
- Cancer Res Treat. 2017;49(2):494-501. Published online August 24, 2016
- DOI: https://doi.org/10.4143/crt.2016.129
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Abstract
PDFPubReaderePub
- Purpose
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
Materials and Methods
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
Results
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
Conclusion
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States. -
Citations
Citations to this article as recorded by- Dosimetric impacts on height development after radiotherapy for intracranial non-germinomatous germ cell tumors
Guanhua Deng, Juan Li, Zhaoming Zhou, Changguo Shan, Jing He, Mingyao Lai, Ping Zhang, Junjie Zhen, Shaoqun Li, Weiping Hong, Xiaolei Hu, Jie Ding, Linbo Cai, Cheng Zhou, Lei Wen
International Journal of Radiation Biology.2025; 101(5): 510. CrossRef - Pediatric sellar teratoma – Case report and review of the literature
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European Journal of Medical Research.2023;[Epub] CrossRef - Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
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PLOS ONE.2023; 18(7): e0288528. CrossRef - The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta‐analysis
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Pediatric Blood & Cancer.2023;[Epub] CrossRef - Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study
Chenggong Zeng, Qunying Yang, Zhuoran Li, Zhiqing Wei, Tingting Chen, Meiling Deng, Jian Wang, Juan Wang, Feifei Sun, Junting Huang, Suying Lu, Jia Zhu, Xiaofei Sun, Zijun Zhen
Journal of Neuro-Oncology.2023; 164(3): 643. CrossRef - Intracranial Germ Cell Tumors
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Seminars in Neurology.2023; 43(06): 897. CrossRef - A Pineal Germinoma with Rapid Enlargement following Tumor Resection
Chia-Jung Hsu, Hsiang-Chih Liao, Dueng-Yuan Hueng, Kuan-Yin Tseng
Diagnostics.2023; 13(23): 3579. CrossRef - Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: a retrospective study
Lei Wen, Juan Li, Mingyao Lai, Zhaoming Zhou, Qingjun Hu, Guanhua Deng, Changguo Shan, Ruyu Ai, Hainan Li, Ming Lu, Liang Zhang, Taihua Wu, Dan Zhu, Yuanyuan Chen, Longhua Chen, Linbo Cai, Cheng Zhou
Strahlentherapie und Onkologie.2022; 198(5): 458. CrossRef - Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors
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Health and Quality of Life Outcomes.2022;[Epub] CrossRef - Hypothalamic syndrome
Hermann L. Müller, Maithé Tauber, Elizabeth A. Lawson, Jale Özyurt, Brigitte Bison, Juan-Pedro Martinez-Barbera, Stephanie Puget, Thomas E. Merchant, Hanneke M. van Santen
Nature Reviews Disease Primers.2022;[Epub] CrossRef - A GIANT GERMINOMA MIMICS HIGH-GRADE GLIOMA: A RARE FORM OF THALAMIC REGION TUMOR
Dirga Rachmad Aprianto, Muhammad Arifin Parenrengi
Wiadomości Lekarskie.2022; 75(8): 2036. CrossRef - Clinical Outcomes and Diagnostic Consistency of Serum and CSF Tumor Markers in Pediatric Intracranial Germ Cell Tumors in Thailand: A Multicenter Study
Lalita Sathitsamitphong, Chalinee Monsereenusorn, Piti Techavichit, Kanjana Shotelersuk, Piradee Suwanpakdee, Piya Rujkijyanont, Pimlak Charoenkwan
Global Pediatric Health.2022;[Epub] CrossRef - Neurological and endocrinological manifestations of 49 children with intracranial pure germinoma at initial diagnosis in Taiwan
Hsin-Yuan Chang, Chiao-Fan Chiu, Shih-Ming Jung, Alex Mun-Ching Wong, Chieh-Tsai Wu, Fu-Sung Lo
Pediatrics & Neonatology.2021; 62(1): 106. CrossRef - Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort
Sean Stephens, Anna Kuchel, Robyn Cheuk, Hamish Alexander, Thomas Robertson, Thulasi Rajah, Quan Tran, Po-ling Inglis
Journal of Clinical Neuroscience.2021; 90: 1. CrossRef - Characteristics of growth disturbances in patients with intracranial germinomas of different origins
Bo Li, Jiayi Wang, Jiongxian Yang, Yanong Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu
Child's Nervous System.2021; 37(8): 2531. CrossRef - A clinical approach to parasellar lesions in the transition age
Emilia Sbardella, Giulia Puliani, Tiziana Feola, Riccardo Pofi, Rosa Pirchio, Franz Sesti, Federica Verdecchia, Daniele Gianfrilli, Daniel Moffat, Andrea M. Isidori, Ashley B. Grossman
Journal of Neuroendocrinology.2021;[Epub] CrossRef - Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999–2017
Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won
Gynecologic Oncology.2021; 163(1): 79. CrossRef - Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae
Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim
Cancer Research and Treatment.2021; 53(4): 983. CrossRef - Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor
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晓红 高
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Takeshi Takayasu, Mauli Shah, Antonio Dono, Yuanqing Yan, Roshan Borkar, Nagireddy Putluri, Jay-Jiguang Zhu, Seiji Hama, Fumiyuki Yamasaki, Hidetoshi Tahara, Kazuhiko Sugiyama, Kaoru Kurisu, Yoshua Esquenazi, Leomar Y. Ballester
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Mohammad H. Abu Arja, Eric Bouffet, Jonathan L. Finlay, Mohamed S. AbdelBaki
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Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 409. CrossRef - Central Nervous System Germ Cell Tumors: A Review of the Literature
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- Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea
- Byung Sup Kim, Ho Jun Seol, Do-Hyun Nam, Chul-Kee Park, Il Han Kim, Tae Min Kim, Jeong Hoon Kim, Young Hyun Cho, Sang Min Yoon, Jong Hee Chang, Seok-Gu Kang, Eui Hyun Kim, Chang-Ok Suh, Tae-Young Jung, Kyung-Hwa Lee, Chae-Yong Kim, In Ah Kim, Chang-Ki Hong, Heon Yoo, Jin Hee Kim, Shin-Hyuk Kang, Min Kyu Kang, Eun-Young Kim, Sun-Hwan Kim, Dong-Sup Chung, Sun-Chul Hwang, Joon-Ho Song, Sung Jin Cho, Sun-Il Lee, Youn-Soo Lee, Kook-Jin Ahn, Se Hoon Kim, Do Hun Lim, Ho-Shin Gwak, Se-Hoon Lee, Yong-Kil Hong
- Cancer Res Treat. 2017;49(1):193-203. Published online June 27, 2016
- DOI: https://doi.org/10.4143/crt.2015.473
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to investigate the feasibility and survival benefits of combined treatment with radiotherapy and adjuvant temozolomide (TMZ) in a Korean sample.
Materials and Methods
A total of 750 Korean patients with histologically confirmed glioblastoma multiforme, who received concurrent chemoradiotherapy with TMZ (CCRT) and adjuvant TMZ from January 2006 until June 2011, were analyzed retrospectively.
Results
After the first operation, a gross total resection (GTR), subtotal resection (STR), partial resection (PR), biopsy alone were achieved in 388 (51.7%), 159 (21.2%), 96 (12.8%), and 107 (14.3%) patients,respectively. The methylation status of O6-methylguanine-DNA methyltransferase (MGMT) was reviewed retrospectively in 217 patients. The median follow-up period was 16.3 months and the median overall survival (OS) was 17.5 months. The actuarial survival rates at the 1-, 3-, and 5-year OS were 72.1%, 21.0%, and 9.0%, respectively. The median progression-free survival (PFS) was 10.1 months, and the actuarial PFS at 1-, 3-, and 5-year PFS were 42.2%, 13.0%, and 7.8%, respectively. The patients who received GTR showed a significantly longer OS and PFS than those who received STR, PR, or biopsy alone, regardless of the methylation status of the MGMT promoter. Patients with a methylated MGMT promoter also showed a significantly longer OS and PFS than those with an unmethylated MGMT promoter. Patients who received more than six cycles of adjuvant TMZ had a longer OS and PFS than those who received six or fewer cycles. Hematologic toxicity of grade 3 or 4 was observed in 8.4% of patients during the CCRT period and in 10.2% during the adjuvant TMZ period.
Conclusion
Patients treated with CCRT followed by adjuvant TMZ had more favorable survival rates and tolerable toxicity than those who did not undergo this treatment. -
Citations
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Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park
Acta Neuropathologica Communications.2024;[Epub] CrossRef - The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Recommendation Using the Delphi Method (Version 2023.1)
Min-Sung Kim, Se-Il Go, Chan Woo Wee, Min Ho Lee, Seok-Gu Kang, Kyeong-O Go, Sae Min Kwon, Woohyun Kim, Yun-Sik Dho, Sung-Hye Park, Youngbeom Seo, Sang Woo Song, Stephen Ahn, Hyuk-Jin Oh, Hong In Yoon, Sea-Won Lee, Joo Ho Lee, Kyung Rae Cho, Jung Won Choi
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Mou Yueyang, Hu Yaqin, Xue Guolian, Zhao Wenjian, Jiao Yang, Li Chen, Cao Haiyan, Chao Min, Deng Jianping, Dai Penggao, Zhu Hongli, Wang Liang
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Kihwan Hwang, Junhyung Kim, Seok‐Gu Kang, Tae‐Young Jung, Jeong Hoon Kim, Se‐Hyuk Kim, Shin‐Hyuk Kang, Yong‐Kil Hong, Tae Min Kim, Yu Jung Kim, Byung Se Choi, Jong Hee Chang, Chae‐Yong Kim
Cancer Medicine.2022; 11(2): 371. CrossRef - Prognostic Value and Risk Factors of Treatment-Related Lymphopenia in Malignant Glioma Patients Treated With Chemoradiotherapy: A Systematic Review and Meta-Analysis
Yongchao Zhang, Shichao Chen, Hualei Chen, Shanshan Chen, Zhen Li, Enshan Feng, Wei Li
Frontiers in Neurology.2022;[Epub] CrossRef - PrACTiC: A Predictive Algorithm for Chemoradiotherapy-Induced Cytopenia in Glioblastoma Patients
Alireza Amouheidari, Zahra Alirezaei, Stefan Rauh, Masoud Hassanpour, Ozkan Kanat
Journal of Oncology.2022; 2022: 1. CrossRef - Relapsing High—Grade Glioma from Peritumoral Zone: Critical Review of Radiotherapy Treatment Options
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Fahimeh Attarian, Farzad Taghizadeh-Hesary, Azar Fanipakdel, Seyed Alireza Javadinia, Pejman Porouhan, Babak PeyroShabany, Danial Fazilat-Panah
Frontiers in Oncology.2021;[Epub] CrossRef - Tumor treating fields plus temozolomide for newly diagnosed glioblastoma: a sub-group analysis of Korean patients in the EF-14 phase 3 trial
Chae-Yong Kim, Sun Ha Paek, Do-hyun Nam, Jong-Hee Chang, Yong-Kil Hong, Jeong Hoon Kim, Oh Lyong Kim, Se-Hyuk Kim
Journal of Neuro-Oncology.2020; 146(3): 399. CrossRef - Risk Factors for Cognitive Impairment in High-Grade Glioma Patients Treated with Postoperative Radiochemotherapy
Qiang Wang, Fengxia Xiao, Fei Qi, Xiaopeng Song, Yonghua Yu
Cancer Research and Treatment.2020; 52(2): 586. CrossRef - Immunotherapy for gliomas: shedding light on progress in preclinical and clinical development
Maria B. Garcia-Fabiani, Maria Ventosa, Andrea Comba, Marianela Candolfi, Alejandro J. Nicola Candia, Mahmoud S. Alghamri, Padma Kadiyala, Stephen Carney, Syed M. Faisal, Anna Schwendeman, James J. Moon, Lindsay Scheetz, Joerg Lahann, Ava Mauser, Pedro R.
Expert Opinion on Investigational Drugs.2020; 29(7): 659. CrossRef Long Intergenic Non-Protein Coding RNA 1094 Promotes Initiation and Progression of Glioblastoma by Promoting microRNA-577-Regulated Stabilization of Brain-Derived Neurotrophic Factor
Xiaoyan Dong, Xiuxin Fu, Miao Yu, Zengfen Li
Cancer Management and Research.2020; Volume 12: 5619. CrossRef- SNHG7 Facilitates Glioblastoma Progression by Functioning as a Molecular Sponge for MicroRNA-449b-5p and Thereby Increasing MYCN Expression
Yaogang Chen, Shaoyong Yuan, Tieying Ning, Huiqing Xu, Bo Guan
Technology in Cancer Research & Treatment.2020;[Epub] CrossRef - Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres
Hyeong-Cheol Oh, Jin-Kyoung Shim, Junseong Park, Ji-Hyun Lee, Ran Joo Choi, Nam Hee Kim, Hyun Sil Kim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Journal of Cancer Research and Clinical Oncology.2020; 146(11): 2817. CrossRef - Clinical Characteristics of High-Grade Glioma with Primary Leptomeningeal Seeding at Initial Diagnosis in a Single Center Study
Ji-Eyon Kwon, Kihwan Hwang, Kyeong-O Go, Chan Woo Wee, In Ah Kim, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Jung Ho Han, Chae-Yong Kim
Brain Tumor Research and Treatment.2020; 8(2): 77. CrossRef - A Longitudinal Study of Lipid Peroxidation and Symptom Clusters in Patients With Brain Cancers
Sanghee Kim
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Yong Wonn Kwon, Won-Jin Moon, Mina Park, Hong Gee Roh, Young Cho Koh, Sang Woo Song, Jin Woo Choi
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Haihui Jiang, Yong Cui, Junmei Wang, Song Lin
Oncotarget.2017; 8(12): 20354. CrossRef
- Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection
- 16,268 View
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- 24 Web of Science
- 28 Crossref
- Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009
- Sang-Hoon Shin, Kyu-Won Jung, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo
- Cancer Res Treat. 2015;47(4):569-574. Published online February 12, 2015
- DOI: https://doi.org/10.4143/crt.2014.085
-
Abstract
PDFPubReaderePub
- Purpose
Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries. Materials and Methods Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.
Results
The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis. Conclusion These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL. -
Citations
Citations to this article as recorded by- All-cause and tumor-specific mortality trends in elderly primary central nervous system lymphoma (PCNSL) patients: a surveillance, epidemiology, and end results (SEER) analysis
Taylor FURST, Haydn HOFFMAN, Lawrence S. CHIN
Journal of Neurosurgical Sciences.2024;[Epub] CrossRef - Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
Raphael Reinecke, Kolja Jahnke, Martha Foltyn‐Dumitru, Karsten Lachner, Moritz Armbrust, Katharina J. Weber, Pia S. Zeiner, Marcus Czabanka, Uta Brunnberg, Sylvia Hartmann, Joachim P. Steinbach, Michael W. Ronellenfitsch
Journal of Neurochemistry.2024; 168(6): 1157. CrossRef - Targeting the tumor microenvironment in primary central nervous system lymphoma: Implications for prognosis
Han Shi, Xuefei Sun, Yuchen Wu, Qu Cui, Shengjun Sun, Nan Ji, Yuanbo Liu
Journal of Clinical Neuroscience.2024; 124: 36. CrossRef - Defining MRI-based follow-up protocol for primary central nervous system lymphoma
Inka K. Puhakka, Kaisa L. Sunela, Aino L. Rönkä, Aino M. Rajamäki, Ulla-Mari Arkko, Tuula M. Klaavuniemi, Milla E.L Kuusisto, Pekka A. Jäkälä, Tuomas A. Selander, Hanne K. Kuitunen, Anne-Mari Kantanen, Outi M. Kuittinen
Annals of Hematology.2024;[Epub] CrossRef - Long term outcomes in older patients with primary central nervous system lymphoma: an analysis of the Texas Cancer Registry
Ethan A. Burns, Cesar Gentille Sanchez, Sunil Mathur, Carlo Guerrero, Ibrahim N. Muhsen, Humaira Sarfraz, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang, Shilpan S. Shah, Ivo W. Tremont, Bin Teh, Siddhartha Ganguly, Sai Ravi Kiran Pingali
Annals of Hematology.2023; 102(5): 1111. CrossRef - Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Yao Hu, Qingyun Zhang, Zhiyuan Wu, Kun Chen, Xiao Xu, Weizhe Ma, Bobin Chen, Limin Jin, Ming Guan
Discover Oncology.2023;[Epub] CrossRef - Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis
Inka Puhakka, Hanne Kuitunen, Pekka Jäkälä, Eila Sonkajärvi, Taina Turpeenniemi-Hujanen, Aino Rönkä, Tuomas Selander, Miika Korhonen, Outi Kuittinen
BMC Cancer.2022;[Epub] CrossRef - Use of rituximab, temozolomide, and radiation in recurrent and refractory primary central nervous system lymphoma in the Philippines: a retrospective analysis
Julette Marie F Batara, Almira Doreen Abigail O Apor, Christianne V Mojica, Mark Willy L Mondia
Neuro-Oncology Advances.2022;[Epub] CrossRef - The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper
Justine R Smith, Alexandra L Farrall, Janet L Davis, Joke H de Boer, Anthony J Hall, Manabu Mochizuki, H Nida Sen, Hiroshi Takase, Ninette H ten Dam-van Loon, Valérie Touitou, Daniel V Vasconcelos-Santos, David J Wilson, Steven Yeh, Mark H B Radford
BMJ Open.2022; 12(7): e060701. CrossRef - Changing Incidence and Survival of Primary Central Nervous System Lymphoma in Australia: A 33-Year National Population-Based Study
Alexandra L. Farrall, Justine R. Smith
Cancers.2021; 13(3): 403. CrossRef - Eye involvement in primary central nervous system lymphoma
Alexandra L. Farrall, Justine R. Smith
Survey of Ophthalmology.2020; 65(5): 548. CrossRef - Characteristics, management and outcome of DLBCL patients, presenting with simultaneous systemic and CNS disease at diagnosis: A retrospective multicenter study
Chava Perry, Sharon Ben Barouch, Neta Goldschmidt, Nadav Sarid, Yair Herishanu, Lev Shvidel, Osnat Bairey, Noa Lavi, Netanel Horowitz, Avraham Avigdor, Eyal Lebel, Orit Sofer, Ron Ram, Irit Avivi
American Journal of Hematology.2019; 94(9): 992. CrossRef - Improved survival in primary central nervous system lymphoma up to age 70 only: a population-based study on incidence, primary treatment and survival in the Netherlands, 1989–2015
M van der Meulen, A G Dinmohamed, O Visser, J K Doorduijn, J E C Bromberg
Leukemia.2017; 31(8): 1822. CrossRef - Role of radiation therapy in primary central nervous system lymphoma
Hyeon Kang Koh, Il Han Kim, Tae Min Kim, Do Hoon Lim, Dongryul Oh, Jae Ho Cho, Woo-Chul Kim, Jin Hee Kim, Woong-Ki Chung, Bae-Kwon Jeong, Ki Mun Kang, Semie Hong, Chang-Ok Suh, In Ah Kim
Journal of Neuro-Oncology.2017; 135(3): 629. CrossRef
- All-cause and tumor-specific mortality trends in elderly primary central nervous system lymphoma (PCNSL) patients: a surveillance, epidemiology, and end results (SEER) analysis
- 12,846 View
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- 15 Web of Science
- 14 Crossref
- Incidence of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors in Korea, 2006-2010
- Kyu-Won Jung, Kwang Hyon Park, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo
- Cancer Res Treat. 2015;47(2):166-172. Published online October 30, 2014
- DOI: https://doi.org/10.4143/crt.2014.017
-
Abstract
PDFPubReaderePub
- Purpose
Primary spinal cord and appendage tumors (PSCAT) originating from the spinal cord, spinal meninges, and cauda equina are uncommon. Worldwide, population-based cancer registry data are mostly based on malignant tumors only, which means few data are available on PSCATs, including non-malignant tumors. Therefore, the objective of this study was to provide information regarding the incidence of both non-malignant and malignant PSCATs in Korea on a national level. Materials and Methods Incidence of PSCATs was estimated from cases diagnosed between 2006 and 2010 using the National Cancer Incidence Database in Korea. Age-adjusted rates were calculated using the world standard population, and male-to-female rate ratios were calculated by histology type. Results Of all PSCATs registered (n=3,312), 86.6% were non-malignant. The overall age-adjusted incidence of PSCATs was 1.08 per 100,000 person-years, with an incidence of 0.99 per 100,000 in females and 1.15 in males. The most common site of PSCATs was the spinal cord (83.4%), followed by spinal meninges (16.1%) and cauda equina (0.5%). The most common histological type was neurilemmoma (41.3%), followed by meningiomas (20.1%) and ependymomas (7.6%). Men had significantly higher rates than women for ependymomas and lymphomas but had lower rates for meningiomas. Conclusion This study provides the first population-based analysis of PSCATs in Korea. -
Citations
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José Alberto Carlos-Escalante, Ángel Antonio Paz-López, Bernardo Cacho-Díaz, Guillermo Pacheco-Cuellar, Gervith Reyes-Soto, Talia Wegman-Ostrosky
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James J. Yahaya
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Ryan G. Chiu, Blake E. Murphy, Amy Zhu, Ankit I. Mehta
World Neurosurgery.2020; 140: e175. CrossRef - Primary Central Nerve System Lymphoma Affecting the Lumbosacral Nerve Root: A Case Report
Junhyung Kim, Bonggyu Ryu, Seung-Jae Hyun, Ki-Jeong Kim
The Nerve.2020; 6(2): 110. CrossRef - Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics
Rachel E. Tsolinas, John F. Burke, Anthony M. DiGiorgio, Leigh H. Thomas, Xuan Duong-Fernandez, Mark H. Harris, John K. Yue, Ethan A. Winkler, Catherine G. Suen, Lisa U. Pascual, Adam R. Ferguson, J. Russell Huie, Jonathan Z. Pan, Debra D. Hemmerle, Vinee
Neurosurgical Focus.2020; 48(5): E6. CrossRef - A Nation-Wide Epidemiological Study of Newly Diagnosed Primary Spine Tumor in the Adult Korean Population, 2009-2011
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Moon Jun Sohn, Sung Hwan Kim
Journal of Korean Neurosurgical Society.2017; 60(2): 195. CrossRef - Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009–2012
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na-Rye Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
Neuro-Oncology Practice.2015; 2(2): 93. CrossRef
- Surgical Strategy for Dumbbell-Shaped Cervical Schwannoma at the Vicinity of the Vertebral Artery: The Utilization of Anatomic Layer
- 11,115 View
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- 10 Crossref
- Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
- Guk Heui Jo, Oliver Bögler, Yong-Joon Chwae, Heon Yoo, Seung Hoon Lee, Jong Bae Park, Youn-Jae Kim, Jong Heon Kim, Ho-Shin Gwak
- Cancer Res Treat. 2015;47(2):221-241. Published online August 29, 2014
- DOI: https://doi.org/10.4143/crt.2013.159
-
Abstract
PDFPubReaderePub
- Purpose
Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced autophagy for cell death nor the existence of autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, has been verified yet. Materials and Methods We observed both temporal and dose-dependent response patterns of autophagy and apoptosis to radiation in MG cell lines. Additionally, we investigated the role of autophagy in apoptosis through knockdown of autophagy-related proteins. Results Autophagic activity measured by staining of acidic vesicle organelles and Western blotting of LC-3 protein increased in proportion to radiation dose from day 1 to 5 after irradiation. Apoptosis measured by annexin-V staining and Western blotting of cleaved poly(ADP-ribose) polymerase demonstrated relatively late appearance 3 days after irradiation that increased for up to 7 days. Blocking of pan-caspase (Z-VAD-FMK) did not affect apoptosis after irradiation, but silencing of Atg5 effectively reduced radiation-induced autophagy, which decreased apoptosis significantly. Inhibition of autophagy in Atg5 knockdown cells was shown to be beneficial for cell survival. Stable transfection of GFP-LC3 cells was observed after irradiation. Annexin-V was localized in cells bearing GFP-LC3 punctuated spots, indicating autophagy in immunofluorescence. Some of these punctuated GFP-LC3 bearing cells formed conglomerated spots and died in final phase. Conclusion These findings suggest that autophagy appears earlier than apoptosis after irradiation and that a portion of the apoptotic population that appears later is autophagy-dependent. Thus, autophagy is a pathway to cell death after irradiation of MG cells. -
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- Surgical Outcomes of Hemorrhagic Metastatic Brain Tumors
- Heon Yoo, Eugene Jung, Ho Shin Gwak, Sang Hoon Shin, Seung Hoon Lee
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- DOI: https://doi.org/10.4143/crt.2011.43.2.102
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Abstract
PDFPubReaderePub
- PURPOSE
Hemorrhagic metastatic brain tumors are not rare, but little is known about the surgical outcome following treatment. We conducted this study to determine the result of the surgical outcome of hemorrhagic metastatic brain tumors.
MATERIALS AND METHODS
From July 2001 to December 2008, 21 patients underwent surgery for hemorrhagic metastatic brain tumors at our institution. 15 patients had lung cancer, 3 had hepatocellular carcinoma, and the rest had rectal cancer, renal cell carcinoma, and sarcoma. 20 patients had macroscopic hemorrhage in the tumors, and one patient had intracerebral hemorrhage surrounding the tumor. A retrospective clinical review was conducted focusing on the patterns of presenting symptoms and signs, as well as local recurrence following surgery.
RESULTS
Among 21 hemorrhagic brain metastases, local recurrence developed in two patients. The 12 month progression free survival rate was 86.1%. Mean time to progression was 20.8 months and median survival time after surgery was 11.7 months.
CONCLUSION
The results of our study showed that hemorrhagic metastatic brain tumors rarely recurred after surgery. Surgery should be considered as a good treatment option for hemorrhagic brain metastasis, especially in cases with increased intracranial pressure or severe neurologic deficits. -
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- Radiation-induced Necrosis Deteriorating Neurological Symptoms and Mimicking Progression of Brain Metastasis after Stereotactic-guided Radiotherapy
- Young Zoon Kim, Dae Yong Kim, Heon Yoo, Hee Seok Yang, Sang Hoon Shin, Eun Kyung Hong, Kwan Ho Cho, Seung Hoon Lee
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Abstract
PDFPubReaderePub
Purpose Although radiation-induced necrosis (RIN) is not a tumor in itself, the lesion progressively enlarges with mass effects and diffuse peritumoral edema in a way that resembles neoplasm. To identify the RIN that mimics progression of brain metastasis, we performed surgical resections of symptomatic RIN lesions.
Meterials and Methods From June 2003 to December 2005, 7 patients received stereotactic-guided radiotherapy (SRT) for metastatic brain tumor, and they later underwent craniotomy and tumor resection due to the progressive mass effects and the peritumoral edema that caused focal neurological deficit. On MR imaging, a ring-like enhanced single lesion with massive peritumoral edema could not be distinguished from progression of brain metastasis.
Results Four patients had non-small cell lung cancer, 2 patients had colorectal cancer and 1 patient had renal cell carcinoma. The mean tumor volume was 8.7 ml (range: 3.0~20.7 ml). The prescribed dose of SRT was 30 Gy with 4 fractions for one patient, 18 Gy for two patients and 20 Gy for the other four patients. The four patients who received SRT with a dose of 20 Gy had RIN with or without microscopic residual tumor cells.
Conclusions Early detection of recurrent disease after radiotherapy and identifying radiation-induced tissue damage are important for delivering adequate treatment. Therefore, specific diagnostic tools that can distinguish RIN from progression of metastatic brain tumor need to be developed.
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