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2 "Hee Yun Seo"
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Original Articles
Clinical Factors Related to Suspected Second Primary Lung Cancer Development in Patients with Head and Neck Cancer
Eui Bae Kim, Yong Park, Seh Jong Park, Dae Sik Kim, Jee Won Kim, Hee Yun Seo, Hwa Jung Sung, In Keun Choi, Kyong Hwa Park, Sang Cheul Oh, Chul Won Choi, Byung Soo Kim, Yeul Hong Kim, Jun Suk Kim, Sang Won Shin, Chul Yong Kim, Kwang-Yoon Jung
Cancer Res Treat. 2008;40(4):178-183.   Published online December 31, 2008
DOI: https://doi.org/10.4143/crt.2008.40.4.178
AbstractAbstract PDFPubReaderePub
Purpose

The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC.

Materials and Methods

We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006.

Results

A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001).

Conclusions

Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.

Citations

Citations to this article as recorded by  
  • African American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer
    Yusra F. Shao, Seongho Kim, John D. Cramer, Dina Farhat, Jeffrey Hotaling, Syed Naweed Raza, George Yoo, Ho‐sheng Lin, Harold Kim, Ammar Sukari, Misako Nagasaka
    Head & Neck.2022; 44(10): 2069.     CrossRef
  • Should fluorodeoxyglucose positron emission tomography/computed tomography be the first-line imaging investigation for restaging the laryngeal carcinoma patients?
    Tarun Jain, Guman Singh, Sumit Goyal, Ajay Yadav, Dinesh Yadav, Nitin Khunteta, Hemant Malhotra
    World Journal of Nuclear Medicine.2021; 20(02): 164.     CrossRef
  • Modern Radiology in the Management of Head and Neck Cancer
    G.J.C. Burkill, R.M. Evans, V.V. Raman, S.E.J. Connor
    Clinical Oncology.2016; 28(7): 440.     CrossRef
  • Synchronous Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia of the Palate
    Pablo Rosado, Soledad Fernández, Luis Junquera, Juan Carlos De Vicente
    Journal of Craniofacial Surgery.2011; 22(1): 348.     CrossRef
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The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer
Yong Park, Jee Won Kim, Dae Sik Kim, Eui Bae Kim, Se Jong Park, Jin Yong Park, Woo Suk Choi, Jong Gyu Song, Hee Yun Seo, Sang Cheul Oh, Byung Soo Kim, Jong Jae Park, Yeul Hong Kim, Jun Suk Kim
Cancer Res Treat. 2008;40(3):127-132.   Published online September 30, 2008
DOI: https://doi.org/10.4143/crt.2008.40.3.127
AbstractAbstract PDFPubReaderePub
Purpose

Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer.

Materials and Methods

Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively.

Results

No significant difference in the mean serum BMP-2 levels was observed between the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p<0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (204.73 pg/ml versus 173.33 pg/ml, p=0.021).

Conclusions

BMP-2 seems to have a role in progression to metastatic disease in gastric cancer, especially in the late stage of tumorigenesis, including invasion and metastasis. BMP-2 may facilitate bone metastasis in gastric cancer. To confirm these findings, further studies are required with tissue specimens and the use of a cancer cell line.

Citations

Citations to this article as recorded by  
  • Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study
    Lazar Chisavu, Viviana Mihaela Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller
    Diagnostics.2024; 14(6): 664.     CrossRef
  • Duality of bone morphogenetic proteins in cancer: A comprehensive analysis
    Tanu Sharma, Anmol Kapoor, Chandi C. Mandal
    Journal of Cellular Physiology.2022; 237(8): 3127.     CrossRef
  • BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer
    Zilu Chen, Liyue Yuan, Xiaopeng Li, Junhui Yu, Zhengshui Xu
    Cell Cycle.2022; 21(21): 2298.     CrossRef
  • Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour
    Alejandro Álvarez-Artime, Belén García-Soler, Rosa María Sainz, Juan Carlos Mayo
    International Journal of Molecular Sciences.2021; 22(11): 5560.     CrossRef
  • Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach
    Jalil Nourisa, Berit Zeller-Plumhoff, Heike Helmholz, Bérengère Luthringer-Feyerabend, Vladimir Ivannikov, Regine Willumeit-Römer
    Computational and Structural Biotechnology Journal.2021; 19: 4110.     CrossRef
  • BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract
    Yongchun Zhang, Jianwen Que
    Annual Review of Physiology.2020; 82(1): 251.     CrossRef
  • Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres
    Sahitya Injamuri, Mohamed N. Rahaman, Youqu Shen, Yue‐Wern Huang
    Journal of Biomedical Materials Research Part A.2020; 108(5): 1231.     CrossRef
  • Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression


    Wan Nuraini Wan Hasan, Kok-Yong Chin, Norzana Abd Ghafar, Ima Nirwana Soelaiman
    Drug Design, Development and Therapy.2020; Volume 14: 969.     CrossRef
  • Detection of circulating BMP5 as a risk factor for Barrett’s esophagus
    Ana C. P. Correia, Silvia Calpe, Nahid Mostafavi, Sanne Johanna Maria Hoefnagel, Maria del Carmen Sancho-Serra, Patricia S. de Koning, Kausilia K. Krishnadath
    Scientific Reports.2020;[Epub]     CrossRef
  • The Dual Role of Bone Morphogenetic Proteins in Cancer
    Duc-Hiep Bach, Hyen Joo Park, Sang Kook Lee
    Molecular Therapy - Oncolytics.2018; 8: 1.     CrossRef
  • Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells
    Tobias Sinnberg, Heike Niessner, Mitch P. Levesque, Christoph Dettweiler, Claus Garbe, Christian Busch
    Biology Open.2018;[Epub]     CrossRef
  • Decreased expression of bone morphogenetic protein-2 is correlated with biochemical recurrence in prostate cancer: Immunohistochemical analysis
    Bum Sik Tae, Seok Cho, Hyun Cheol Kim, Cheol Hwan Kim, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim, Hong Seok Park, Jun Cheon, Mi Mi Oh, Sung Gu Kang
    Scientific Reports.2018;[Epub]     CrossRef
  • Computational model of mesenchymal migration in 3D under chemotaxis
    F. O. Ribeiro, M. J. Gómez-Benito, J. Folgado, P. R. Fernandes, J. M. García-Aznar
    Computer Methods in Biomechanics and Biomedical Engineering.2017; 20(1): 59.     CrossRef
  • Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy
    Haijun Tian, Jie Zhao, Elsa J. Brochmann, Jeffrey C. Wang, Samuel S. Murray
    Cytokine & Growth Factor Reviews.2017; 34: 73.     CrossRef
  • BMP signaling pathways affect differently migration and invasion of esophageal squamous cancer cells
    Min Hu, Facai Cui, Fengzhen Liu, Jinlin Wang, Xiaoxia Wei, Yi Li
    International Journal of Oncology.2017; 50(1): 193.     CrossRef
  • Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis
    Jian Sun, Xuan Liu, Hong Gao, Long Zhang, Qing Ji, Ziyuan Wang, Lihong Zhou, Yan Wang, Hua Sui, Zhongze Fan, Qi Li
    Oncotarget.2017; 8(7): 11489.     CrossRef
  • BMP10 inhibited the growth and migration of gastric cancer cells
    Haiming Lei, Jian Wang, Peihua Lu, Xinghua Si, Koulan Han, Tingyan Ruan, Junjie Lu
    Tumor Biology.2016; 37(3): 3025.     CrossRef
  • How does the pathophysiological context influence delivery of bone growth factors?
    Xiaohua Yu, Darilis Suárez-González, Andrew S. Khalil, William L. Murphy
    Advanced Drug Delivery Reviews.2015; 84: 68.     CrossRef
  • Inactivation of the Phosphatidylinositol 3‐Kinase/Akt Pathway is Involved in BMP9‐mediated Tumor‐suppressive Effects in Gastric Cancer Cells
    Liang Duan, Liwei Ye, Rui Wu, Haiyan Wang, Xueru Li, Huan Li, Shimei Yuan, He Zha, Hui Sun, Yunyuan Zhang, Xian Chen, Yan Zhang, Lan Zhou
    Journal of Cellular Biochemistry.2015; 116(6): 1080.     CrossRef
  • Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2
    Yun-Jung Choi, Patrick N. Ingram, Kun Yang, Lan Coffman, Mangala Iyengar, Shoumei Bai, Dafydd G. Thomas, Euisik Yoon, Ronald J. Buckanovich
    Proceedings of the National Academy of Sciences.2015;[Epub]     CrossRef
  • Association Between BMP-2 and Carcinogenicity
    Branko Skovrlj, Steven M. Koehler, Paul A. Anderson, Sheeraz A. Qureshi, Andrew C. Hecht, James C. Iatridis, Samuel K. Cho
    SPINE.2015; 40(23): 1862.     CrossRef
  • In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2
    Frederico O. Ribeiro, María José Gómez-Benito, João Folgado, Paulo R. Fernandes, José Manuel García-Aznar, Masaya Yamamoto
    PLOS ONE.2015; 10(6): e0127722.     CrossRef
  • Comparative transcriptome analysis between metastatic and non-metastatic gastric cancer reveals potential biomarkers
    DAN FENG, XIAOFEI YE, ZHENXIN ZHU, ZIRAN WEI, QINGPING CAI, YAJIE WANG
    Molecular Medicine Reports.2015; 11(1): 386.     CrossRef
  • Gastric stem cells and gastric cancer stem cells
    Myoung-Eun Han, Sae-Ock Oh
    Anatomy & Cell Biology.2013; 46(1): 8.     CrossRef
  • Cancer stem cells: the ‘heartbeat’ of gastric cancer
    Guihua Xu, Jie Shen, Xiaohui Ou Yang, Masakiyo Sasahara, Xiulan Su
    Journal of Gastroenterology.2013; 48(7): 781.     CrossRef
  • Serum BMP-2 Up-regulation as an Indicator of Poor Survival in Advanced Non-small Cell Lung Cancer Patients
    Zheng-Hua Fei, Cheng-Yun Yao, Xiao-Lei Yang, Xin-En Huang, Sheng-Lin Ma
    Asian Pacific Journal of Cancer Prevention.2013; 14(9): 5293.     CrossRef
  • P‐glycoprotein (ABCB1) inhibited network of mitochondrion transport along microtubule and BMP signal‐induced cell shape in chimpanzee left cerebrum by systems‐theoretical analysis
    Hong Lin, Lin Wang, Minghu Jiang, Juxiang Huang, Lianxiu Qi
    Cell Biochemistry and Function.2012; 30(7): 582.     CrossRef
  • Bone–vasculature interactions in the mandible: Is bone an angiogenic tissue?
    E.M. Dietrich, K. Antoniades
    Medical Hypotheses.2012; 79(5): 582.     CrossRef
  • Major Determinants of BMP-2 Serum Levels in Hemodialysis Patients
    Elísio Costa, Joana Coimbra, Cristina Catarino, Sandra Ribeiro, Flávio Reis, Henrique Nascimento, João Fernandes, Vasco Miranda, Maria do Sameiro Faria, Luís Belo, Alice Santos-Silva
    Renal Failure.2012; 34(10): 1355.     CrossRef
  • Bone Morphogenetic Protein-4-induced Epithelial-Mesenchymal Transition and Invasiveness Through Smad1-mediated Signal Pathway in Squamous Cell Carcinoma of the Head and Neck
    Ting Xu, Chang-yun Yu, Jin-jie Sun, Yong Liu, Xing-wei Wang, Lei-ming Pi, Yong-quan Tian, Xin Zhang
    Archives of Medical Research.2011; 42(2): 128.     CrossRef
  • Bone Morphogenetic Protein-2 and -4 Play Tumor Suppressive Roles in Human Diffuse-Type Gastric Carcinoma
    Yo-taro Shirai, Shogo Ehata, Masakazu Yashiro, Kazuyoshi Yanagihara, Kosei Hirakawa, Kohei Miyazono
    The American Journal of Pathology.2011; 179(6): 2920.     CrossRef
  • Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression
    Myoung Hee Kang, Sang Cheul Oh, Hyun Joo Lee, Han Na Kang, Jung Lim Kim, Jun Suk Kim, Young A. Yoo
    Experimental Cell Research.2011; 317(12): 1746.     CrossRef
  • Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma
    Ulrike Maegdefrau, Stephanie Arndt, Georgi Kivorski, Claus Hellerbrand, Anja-Katrin Bosserhoff
    Laboratory Investigation.2011; 91(11): 1615.     CrossRef
  • Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy
    JIN-SOON SUH, WON-HO HAHN, JONG SEOK LEE, HAE JEONG PARK, MI-JA KIM, SUNG WOOK KANG, JOO-HO CHUNG, BYOUNG-SOO CHO
    Experimental and Therapeutic Medicine.2011; 2(2): 337.     CrossRef
  • Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
    Yong Park, Myoung Hee Kang, Hee Yeon Seo, Joong Min Park, Chul Won Choi, Yeul Hong Kim, In Sun Kim, Jun Suk Kim, Sang Cheul Oh
    Medical Oncology.2010; 27(4): 1192.     CrossRef
  • The Yin and Yang of bone morphogenetic proteins in cancer
    Ashok Singh, Rebecca J. Morris
    Cytokine & Growth Factor Reviews.2010; 21(4): 299.     CrossRef
  • BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway
    Myoung Hee Kang, Jun Suk Kim, Ji Eun Seo, Sang Cheul Oh, Young A. Yoo
    Experimental Cell Research.2010; 316(1): 24.     CrossRef
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