Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
1 "Hairong Xiong"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
MiR-1246 Promotes Metastasis and Invasion of A549 cells by Targeting GSK-3β‒Mediated Wnt/β-Catenin Pathway
Fan Yang, Hairong Xiong, Li Duan, Qian Li, Xin Li, Yongqin Zhou
Cancer Res Treat. 2019;51(4):1420-1429.   Published online March 4, 2019
DOI: https://doi.org/10.4143/crt.2018.638
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
MicroRNAs (miRNAs) are a group of small non-coding RNAs involved in different cancers, including lung cancer. Here, we aim to investigate the expression profiles of circulating miRNAs and their roles contributed to the progress of lung cancer.
Materials and Methods
The levels of circulating miRNA in lung cancer patients were investigated by miRNAs assay. Then we predicted the target genes of aberrantly expressing miRNAs by searching genetic databases. Based on the A549 cells transfected with miR-1246 mimics or miR-1246 inhibitor,we further measured the roles of miR-1246 involving in the epithelial-mesenchymal transition (EMT), migration and invasion capacities of lung cancer cells in vitro. Finally, we detected the effects of miR-1246 on glycogen synthase kinase-3β (GSK-3β)/β-catenin pathway by immunofluorescence and Western blot, respectively.
Results
We identified that 14 miRNAs were aberrantly expressed in the serum of lung cancer patients. Among them, miR-1246 was the most up-regulated. The cell assays indicated that miR-1246 significantly increased the migration and invasion capabilities of A549 lung cancer cells. Meanwhile, immunofluorescence analysis revealed that miR-1246 promoted EMT process of A549 cells accompanying with decreasing E-cadherin expression, while increasing vimentin and transforming growth factor β (TGF-β) expression. Furthermore, an online tool predicated that miR-1246 might bind to 3′-untranslated region of GSK-3β, which was confirmed by overexpression and knockdown of miR-1246 assays.
Conclusion
Taken together, the study illustrates that miR-1246 regulates Wnt/β-catenin pathway through targeting GSK-3β/β-catenin, which partly contributing to tumor metastasis. MiR-1246 may play an essential role in the diagnosis and therapeutic of lung cancer.

Citations

Citations to this article as recorded by  
  • Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity
    Zhengang Ding, Zineng Yan, Xun Yuan, Guangzhao Tian, Jiang Wu, Liwei Fu, Han Yin, Songlin He, Chao Ning, Yazhe Zheng, Zhichao Zhang, Xiang Sui, Libo Hao, Yuting Niu, Shuyun Liu, Weimin Guo, Quanyi Guo
    Journal of Nanobiotechnology.2024;[Epub]     CrossRef
  • Small Extracellular Vesicles Derived from Helicobacter Pylori‐Infected Gastric Cancer Cells Induce Lymphangiogenesis and Lymphatic Remodeling via Transfer of miR‐1246
    Chen Lu, Li Xie, Shengkui Qiu, Tianlu Jiang, Luyao Wang, Zetian Chen, Yiwen Xia, Jialun Lv, Ying Li, Bowen Li, Chao Gu, Zekuan Xu
    Small.2024;[Epub]     CrossRef
  • Wnt/β-catenin Signaling in Lung Cancer: Association with Proliferation, Metastasis, and Therapy Resistance
    Maliheh Entezari, Mahshid Deldar Abad Paskeh, Sima Orouei, Amirabbas Kakavand, Shamin Rezaei, Elahe Sadat Hejazi, Parya Pashootan, Naghmeh Nazdari, Alireza Tavakolpournegari, Mehrdad Hashemi, Shokooh Salimimoghadam, Sepideh Mirzaei, Afshin Taheriazam, Sae
    Current Cancer Drug Targets.2024; 24(1): 94.     CrossRef
  • Exosomal derived miR-1246 from hydroquinone-transformed cells drives S phase accumulation arrest by targeting cyclin G2 in TK6 cells
    Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
    Chemico-Biological Interactions.2024; 387: 110809.     CrossRef
  • Role of adhesion molecules in cancer and targeted therapy
    Chunmei Fan, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Qianjin Liao, Guiyuan Li, Can Guo, Wei Xiong, He Huang, Zhaoyang Zeng
    Science China Life Sciences.2024; 67(5): 940.     CrossRef
  • Wnt/β-catenin-driven EMT regulation in human cancers
    Wenhua Xue, Lin Yang, Chengxin Chen, Milad Ashrafizadeh, Yu Tian, Ranran Sun
    Cellular and Molecular Life Sciences.2024;[Epub]     CrossRef
  • miR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2
    Shuai Yang, Qingping Zou, Ying Liang, Dapeng Zhang, Lina Peng, Wei Li, Wenxuan Li, Mengxing Liu, Ying Tong, Lu Chen, Peng Xu, Zhicong Yang, Kaicheng Zhou, Jianru Xiao, Hailin Wang, Wenqiang Yu
    MedComm.2024;[Epub]     CrossRef
  • miR-1246-overexpressing exosomes improve UVB-induced photoaging by activating autophagy via suppressing GSK3β
    Wei Gao, Limin Yuan, Yue Zhang, Fangzhou Huang, Chen Ai, Tianci Lv, Jiale Chen, Hui Wang, Yixin Ling, Yu-shuai Wang
    Photochemical & Photobiological Sciences.2024; 23(5): 957.     CrossRef
  • Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer
    Caiyan Yin, Jianwei Yu, Gaohua Liu, Jun He, Peng Wu
    Pathology - Research and Practice.2024; 257: 155315.     CrossRef
  • Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma
    Farah Ramadan, Raya Saab, Farah Ghamloush, Rita Khoueiry, Zdenko Herceg, Ludovic Gomez, Bassam Badran, Philippe Clezardin, Nader Hussein, Pascale A. Cohen, Sandra E. Ghayad
    Cancers.2024; 16(9): 1652.     CrossRef
  • Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
    Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yunxi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia, Zhenfang Du
    Journal of Translational Medicine.2024;[Epub]     CrossRef
  • A study of microRNAs as new prognostic biomarkers in anal cancer patients
    Olav Dahl, Mette Pernille Myklebust
    Acta Oncologica.2024; 63: 456.     CrossRef
  • Extracellular vesicles from highly invasive melanoma subpopulations increase the invasive capacity of less invasive melanoma cells through mir-1246-mediated inhibition of CCNG2
    Tim Kingreen, Stefanie Kewitz-Hempel, Christian Rohde, Gerd Hause, Cord Sunderkötter, Dennis Gerloff
    Cell Communication and Signaling.2024;[Epub]     CrossRef
  • Identification of common salivary miRNA in oral lichen planus and oral squamous cell carcinoma: systematic review and meta-analysis
    Maryam Koopaie, Parisa Akhbari, Mahnaz Fatahzadeh, Sajad Kolahdooz
    BMC Oral Health.2024;[Epub]     CrossRef
  • Exosomal microRNAs in cancer metastasis: A bridge between tumor micro and macroenvironment
    Mohamed J. Saadh, Amirmohammad Khalifehsoltani, Abbas Hameed Abdul Hussein, Omer Qutaiba B. Allela, Hayder Naji Sameer, Jasur Rizaev, Huda Ghassan Hameed, Ameer Hassan Idan, Fahad Alsaikhan
    Pathology - Research and Practice.2024; 263: 155666.     CrossRef
  • Research progress of lncRNA and miRNA in hepatic ischemia-reperfusion injury
    Shan-Fei Zhu, Wei Yuan, Yong-Liang Du, Bai-Lin Wang
    Hepatobiliary & Pancreatic Diseases International.2023; 22(1): 45.     CrossRef
  • MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata
    Si-si Qi, Ying Miao, You-yu Sheng, Rui-ming Hu, Jun Zhao, Qin-ping Yang
    Annals of Dermatology.2023; 35(1): 46.     CrossRef
  • Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β‐catenin signaling in rats
    Taiwei Wang, Xuemiao Huang, Jian Liu, Wei Liu, Zhaoyun Yang, Kang He, Junyu Chen, Lijing Zhao
    Environmental Toxicology.2023; 38(5): 1143.     CrossRef
  • MITF Downregulation Induces Death in Human Mast Cell Leukemia Cells and Impairs IgE-Dependent Degranulation
    Elizabeth Proaño-Pérez, Laia Ollé, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Muñoz-Cano, Margarita Martin
    International Journal of Molecular Sciences.2023; 24(4): 3515.     CrossRef
  • The ameliorative effect of CangFu Daotan Decoction on polycystic ovary syndrome of rodent model is associated with m6A methylation and Wnt/β-catenin pathway
    Yuwei Zhang, Haili Zhou, Caifei Ding
    Gynecological Endocrinology.2023;[Epub]     CrossRef
  • The role of selected non-coding RNAs in the biology of non-small cell lung cancer
    Kajetan Kiełbowski, Konrad Ptaszyński, Janusz Wójcik, Małgorzata Edyta Wojtyś
    Advances in Medical Sciences.2023; 68(1): 121.     CrossRef
  • Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control
    Afshin Taheriazam, Seyedeh Delaram Bayanzadeh, Melika Heydari Farahani, Sarah Mojtabavi, Mohammad Arad Zandieh, Sadaf Gholami, Mohammad Hossein Heydargoy, Maryam Jamali Hondori, Zahra Kangarloo, Mitra Behroozaghdam, Ramin Khorrami, Mohammad Ali Sheikh Bei
    European Journal of Pharmacology.2023; 951: 175781.     CrossRef
  • Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata
    Sijie Wei, Lihua Geng, Haoyu Yu, Jing Wang, Yang Yue, Quanbin Zhang, Ning Wu
    Molecules.2023; 28(11): 4343.     CrossRef
  • Novel shikonin derivative suppresses tumor growth and metastasis intervention of Wnt/β-catenin pathway
    Hongwei Han, Zhongling Wen, Xiaohui Lai, Minkai Yang, Jiangyan Fu, Liangjie Yang, Qingqing Chen, Yudi Ma, Wencai Jie, Changyi Wang, Tongming Yin, Guihua Lu, Xiaoming Wang, Shucun Sun, Quan Zhao, Jinliang Qi, Hongyan Lin, Yonghua Yang
    Process Biochemistry.2023; 132: 297.     CrossRef
  • miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
    Wenjian Cen, Qin Yan, Wenpeng Zhou, Minjie Mao, Qitao Huang, Yaobin Lin, Neng Jiang
    Cellular Oncology.2023; 46(6): 1821.     CrossRef
  • Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
    Elizabeth Córdoba-Lanús, Angélica Domínguez de-Barros, Alexis Oliva, Delia Mayato, Francisca Gonzalvo, Ana Remírez-Sanz, Javier J. Zulueta, Bartolomé Celli, Ciro Casanova
    International Journal of Molecular Sciences.2023; 24(15): 12437.     CrossRef
  • MicroRNAs in idiopathic inflammatory myopathies: state-of-the-art and future perspectives
    Federico Pettorossi, Michela Gasparotto, Anna Ghirardello, Chiara Franco, Giulio Ceolotto, Alessandra Giannella, Luca Iaccarino, Elisabetta Zanatta, Andrea Doria, Mariele Gatto
    Current Opinion in Rheumatology.2023; 35(6): 374.     CrossRef
  • Current landscape of miRNAs and TGF‐β signaling in lung cancer progression and therapeutic targets
    Bashdar Mahmud Hussen, Safeen Jasim Saleem, Snur Rasool Abdullah, Sayran Mohamadtahr, Hazha Jamal Hidayat, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
    Molecular and Cellular Probes.2023; 72: 101929.     CrossRef
  • miR‐199a/214 cluster enhances prostate cancer sensitiveness to nimotuzumab via targeting TBL1XR1
    Sheng Hu, Qiang Zhou, Qiang Lu, Xi Guo, Yong Wang, Yi‐Xing Duan
    The Kaohsiung Journal of Medical Sciences.2023; 39(12): 1178.     CrossRef
  • A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies
    Riya Thapa, Gaurav Gupta, Asif Ahmad Bhat, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Shakir Saleem, Ruqaiyah Khan, Najla Altwaijry, Harish Dureja, Sachin Kumar Singh, Kamal Dua
    International Journal of Biological Macromolecules.2023; 253: 127375.     CrossRef
  • Prospects of microRNAs as therapeutic biomarkers in non-small cell lung cancer
    Jennifer Sally Samson, Venkatachalam Deepa Parvathi
    Medical Oncology.2023;[Epub]     CrossRef
  • Identification of serum miR-1246 and miR-150-5p as novel diagnostic biomarkers for high-grade serous ovarian cancer
    Magdalena Niemira, Anna Erol, Agnieszka Bielska, Anna Zeller, Anna Skwarska, Karolina Chwialkowska, Mariusz Kuzmicki, Jacek Szamatowicz, Joanna Reszec, Pawel Knapp, Marcin Moniuszko, Adam Kretowski
    Scientific Reports.2023;[Epub]     CrossRef
  • MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth
    Jingyan Li, Zhanlei Zhang, Jieting Hu, Xiaoting Wan, Wei Huang, Hong Zhang, Ningyi Jiang
    Molecular and Cellular Biochemistry.2022; 477(3): 649.     CrossRef
  • A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers
    Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • The roles of G3BP1 in human diseases (review)
    Yidong Ge, Jiabei Jin, Jinyun Li, Meng Ye, Xiaofeng Jin
    Gene.2022; 821: 146294.     CrossRef
  • miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting AXIN2 and CFTR
    Rokas Lukosevicius, Simonas Juzenas, Violeta Salteniene, Ugne Kulokiene, Justina Arstikyte, Georg Hemmrich-Stanisak, Andre Franke, Alexander Link, Paulius Ruzgys, Saulius Satkauskas, Henrikas Pauzas, Tadas Latkauskas, Gediminas Kiudelis, Francesc Balaguer
    International Journal of Molecular Sciences.2022; 23(4): 2107.     CrossRef
  • Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer
    Teng-Fei Yin, Shi-Yu Du, Dong-Yan Zhao, Xi-Zhen Sun, Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou, Shu-Kun Yao
    World Journal of Clinical Cases.2022; 10(11): 3352.     CrossRef
  • Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases
    Sherona R. Sirkisoon, Grace L. Wong, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo
    Cancer Letters.2022; 540: 215726.     CrossRef
  • MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17
    Zhengcheng Liu, Wei Zhao, Rusong Yang
    Environmental Toxicology.2022; 37(11): 2651.     CrossRef
  • APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b
    Giulia Antoniali, Emiliano Dalla, Giovanna Mangiapane, Xiaolong Zhao, Xinming Jing, Yi Cheng, Veronica De Sanctis, Dilara Ayyildiz, Silvano Piazza, Mengxia Li, Gianluca Tell
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • miR-1246 Promotes Laryngeal Squamous Cell Carcinoma Progression by Interacting with THBS1
    Lifeng Wu, Na Zuo, Shuo Pan, Yue Wang, Qixue Wang, Jun Ma
    Journal of Environmental Pathology, Toxicology and Oncology.2022; 41(3): 65.     CrossRef
  • Cancer associated fibroblasts secreted exosomal miR-1290 contributes to prostate cancer cell growth and metastasis via targeting GSK3β
    Shuo Wang, Peng Du, Yudong Cao, Jinchao Ma, Xiao Yang, Ziyi Yu, Yong Yang
    Cell Death Discovery.2022;[Epub]     CrossRef
  • Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
    Umaporn Limothai, Nattawat Jantarangsi, Natthasit Suphavejkornkij, Sasipha Tachaboon, Janejira Dinhuzen, Watchadaporn Chaisuriyong, Supachoke Trongkamolchai, Mananya Wanpaisitkul, Chatchai Chulapornsiri, Anongrat Tiawilai, Thawat Tiawilai, Terapong Tantaw
    PLOS Neglected Tropical Diseases.2022; 16(10): e0010836.     CrossRef
  • miRNAs in anti-cancer drug resistance of non-small cell lung cancer: Recent advances and future potential
    Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Application of bioactive metal ions in the treatment of bone defects
    Shaorong Li, Yutao Cui, He Liu, Yuhang Tian, Gan Wang, Yi Fan, Jingwei Wang, Dankai Wu, Yanbing Wang
    Journal of Materials Chemistry B.2022; 10(45): 9369.     CrossRef
  • ExoBCD: a comprehensive database for exosomal biomarker discovery in breast cancer
    Xuanyi Wang, Zixuan Chai, Guizhi Pan, Youjin Hao, Bo Li, Ting Ye, Yinghong Li, Fei Long, Lixin Xia, Mingwei Liu
    Briefings in Bioinformatics.2021;[Epub]     CrossRef
  • MicroRNAs and Lung Cancer: A Review Focused on Targeted Genes
    Yao-Hui Wang, Zhi-Ruo Zhu, De Tong, Rui Zhou, Kui Xiao, Ling Peng
    Exploratory Research and Hypothesis in Medicine.2021; 000(000): 1.     CrossRef
  • Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion
    Mingyu Qian, Zihang Chen, Xiaofan Guo, Shaobo Wang, Zongpu Zhang, Wei Qiu, Yanhua Qi, Shouji Zhang, Jianye Xu, Rongrong Zhao, Hao Xue, Gang Li
    Laboratory Investigation.2021; 101(5): 612.     CrossRef
  • MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer
    Shengjie Tang, Shuangjiang Li, Tao Liu, Yiwei He, Haiyang Hu, Yunhe Zhu, Shoujun Tang, Haining Zhou
    Cancer Letters.2021; 502: 71.     CrossRef
  • CD9 Upregulation-Decreased CCL21 Secretion in Mesenchymal Stem Cells Reduces Cancer Cell Migration
    Chia-Chu Hsieh, Szu-Chun Hsu, Ming Yao, Dong-Ming Huang
    International Journal of Molecular Sciences.2021; 22(4): 1738.     CrossRef
  • Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients
    Eijiro Ueta, Koichiro Tsutsumi, Hironari Kato, Hiroshi Matsushita, Hidenori Shiraha, Masakuni Fujii, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada
    Scientific Reports.2021;[Epub]     CrossRef
  • Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions
    Kazuya Kusama, Mohammad B. Rashid, Rasoul Kowsar, Mohamed A. Marey, Anup K. Talukder, Kentaro Nagaoka, Masayuki Shimada, Hasan Khatib, Kazuhiko Imakawa, Akio Miyamoto
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • MiRNAs and Cancer: Key Link in Diagnosis and Therapy
    Yu Shi, Zihao Liu, Qun Lin, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Chang Gong
    Genes.2021; 12(8): 1289.     CrossRef
  • Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway
    Fengfeng Sun, Peng Sun, Xiaofeng Yang, Liangliang Hu, Jianguo Gao, Tao Tian
    Aging.2021; 13(18): 22528.     CrossRef
  • Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer
    Xuyang Liang, Zhimei Zhang, Lu Wang, Shuxian Zhang, Ling Ren, Shouying Li, Jing Xu, Shengxiang Lv
    Bioengineered.2021; 12(2): 10023.     CrossRef
  • MicroRNA-1246 Mediates Drug Resistance and Metastasis in Breast Cancer by Targeting NFE2L3
    Yue-chu Dai, Yin Pan, Ming-ming Quan, Qi Chen, Yue Pan, Yan-yun Ruan, Jian-guo Sun
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23 Transcription
    Lu Cai, Qian Zhang, Lili Du, Feiyun Zheng
    Cytogenetic and Genome Research.2021; 161(10-11): 488.     CrossRef
  • Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo
    Petro Zhupanyn, Alexander Ewe, Thomas Büch, Anastasia Malek, Phil Rademacher, Claudia Müller, Anja Reinert, Yarúa Jaimes, Achim Aigner
    Journal of Controlled Release.2020; 319: 63.     CrossRef
  • MiRNAs and LncRNAs: Dual Roles in TGF-β Signaling-Regulated Metastasis in Lung Cancer
    Xing-Ning Lai, Jun Li, Li-Bo Tang, Wen-Tong Chen, Lei Zhang, Li-Xia Xiong
    International Journal of Molecular Sciences.2020; 21(4): 1193.     CrossRef
  • Maimendong and Qianjinweijing Tang (Jin formula) suppresses lung cancer by regulation of miR-149-3p
    Zequn Jiang, Yanxia Ma, Tian Tian, Yan Sun, Hao Chen, Ye Lu, Yan Wu, Haiying Jiang, Wenting Li, Li Li, Hongguang Zhou, Mianhua Wu
    Journal of Ethnopharmacology.2020; 258: 112836.     CrossRef
  • Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective
    Beatrice Aramini, Valentina Masciale, Khawaja Husnain Haider
    World Journal of Stem Cells.2020; 12(6): 406.     CrossRef
  • Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains
    Loredana Guglielmi, Marta Nardella, Carla Musa, Ingrid Cifola, Manuela Porru, Beatrice Cardinali, Ilaria Iannetti, Chiara Di Pietro, Giulia Bolasco, Valentina Palmieri, Laura Vilardo, Nicolò Panini, Fabrizio Bonaventura, Massimiliano Papi, Ferdinando Scav
    Cancers.2020; 12(6): 1635.     CrossRef
  • Downregulation of DUSP9 Promotes Tumor Progression and Contributes to Poor Prognosis in Human Colorectal Cancer
    Zhaoyan Qiu, Ning Liang, Qian Huang, Tao Sun, Hongyuan Xue, Tianyu Xie, Xinxin Wang, Qian Wang
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Circulating miR-1246 in the Progression of Chronic Obstructive Pulmonary Disease (COPD) in Patients from the BODE Cohort


    Sara Cazorla-Rivero, Glorian Mura-Escorche, Francisca Gonzalvo-Hernández, Delia Mayato, Elizabeth Córdoba-Lanús, Ciro Casanova
    International Journal of Chronic Obstructive Pulmonary Disease.2020; Volume 15: 2727.     CrossRef
  • miR-1260b Activates Wnt Signaling by Targeting Secreted Frizzled-Related Protein 1 to Regulate Taxane Resistance in Lung Adenocarcinoma
    Jin Ren, Deqiang Wang, Hanpeng Huang, Xiaoqin Li, Xiufen Zhuang, Jian Li
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Exosomes derived from human umbilical cord blood mesenchymal stem cells improve hepatic ischemia reperfusion injury via delivering miR-1246
    Kun Xie, Lei Liu, Jiangming Chen, Fubao Liu
    Cell Cycle.2019; 18(24): 3491.     CrossRef
  • 11,255 View
  • 381 Download
  • 75 Web of Science
  • 66 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP