Cancer Research and Treatment

Original Articles

Using the Lymph Node Ratio to Evaluate the Prognosis of Stage II/III Breast Cancer Patients Who Received Neoadjuvant Chemotherapy and Mastectomy: San-Gang Wu, Qun Li, Juan Zhou, Jia-Yuan Sun, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Xun-Xing Gaun, Zhen-Yu He; Cancer Res Treat. 2015;47(4):757-764. Published online December 8, 2014; DOI: https://doi.org/10.4143/crt.2014.039

Purpose
This study was conducted to investigate the prognostic value of lymph node ratio (LNR) in stage II/III breast cancer patients who undergo mastectomy after neoadjuvant chemotherapy.
Materials and Methods
Clinical and pathological data describing stage II/III breast cancer patients were included in this retrospective study. The primary outcomes were locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS).
Results
Among 277 patients, there were 43 ypN0, 64 ypN1, 89 ypN2, and 81 ypN3 cases. Additionally, there were 43, 57, 92 and 85 cases in the LNR 0, 0.01-0.20, 0.21-0.65, and > 0.65 groups, respectively. The median follow-up was 49.5 months. Univariate analysis showed that both ypN stage and LNR were prognostic factors of LRFS, DMFS, DFS, and OS (p < 0.05). Multivariate analysis showed that LNR was an independent prognostic factor of LRFS, DMFS, DFS, and OS (p < 0.05), while ypN stage had no effect on prognosis (p > 0.05).
Conclusion
The integrated use of LNR and ypN may be suitable for evaluation the prognosis of stage II/III breast cancer patients who undergo mastectomy after neoadjuvant chemotherapy.

Citations

Citations to this article as recorded by

Prognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study
Lingfeng Tang, Linshan Jiang, Xiujie Shu, Yudi Jin, Haochen Yu, Shengchun Liu
Scientific Reports.2024;[Epub] CrossRef
Prognostic disparities in young patients based on breast cancer subtype: A population-based study from the SEER database
Bing Chen, Xiaojuan Zhang, Yi Liu, Chuandong Wang
Medicine.2023; 102(13): e33416. CrossRef
The Effect of Lymph Node Harvest on Prognosis in Locally Advanced Middle-Low Rectal Cancer After Neoadjuvant Chemoradiotherapy
Zhuangbin Lin, Xiaobo Li, Jianyuan Song, Rong Zheng, Cheng Chen, Anchuan Li, Benhua Xu
Frontiers in Oncology.2022;[Epub] CrossRef
Breast Cancer Patients With Positive Apical or Infraclavicular/Ipsilateral Supraclavicular Lymph Nodes Should Be Excluded in the Application of the Lymph Node Ratio System
Zhe Wang, Wei Chong, Huikun Zhang, Xiaoli Liu, Yawen Zhao, Zhifang Guo, Li Fu, Yongjie Ma, Feng Gu
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
Is Pathologic Axillary Staging Valid If Lymph Nodes Are Less than 10 with Axillary Lymph Node Dissection after Neoadjuvant Chemotherapy?
Hee Jun Choi, Jai Min Ryu, Jun Ho Lee, Yoonju Bang, Jongwook Oh, Byung-Joo Chae, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Se Kyung Lee, Jonghan Yu
Journal of Clinical Medicine.2022; 11(21): 6564. CrossRef
A novel nomogram for predicting locoregional recurrence risk in breast cancer patients treated with neoadjuvant chemotherapy and mastectomy
Zhou Huang, Mei Shi, Wei-Hu Wang, Liang-Fang Shen, Yu Tang, Qing-Lin Rong, Li Zhu, Xiao-Bo Huang, Jian Tie, Jia-Yi Chen, Jun Zhang, Hong-Fen Wu, Jing Cheng, Min Liu, Chang-Ying Ma, Shu-Lian Wang, Ye-Xiong Li
Radiotherapy and Oncology.2021; 161: 191. CrossRef
Lymph node ratio as best prognostic factor in triple‐negative breast cancer patients with residual disease after neoadjuvant chemotherapy
Gabriel A. De la Cruz‐Ku, Diego Chambergo‐Michilot, Bryan Valcarcel, Pamela Rebaza, Mecker Möller, Jhajaira M. Araujo, Daniel Enriquez, Zaida Morante, Cesar Razuri, Renato Luque, Antonella Saavedra, Eduardo Eyzaguirre, Maria Lujan, Naysha Noel, Joseph Pin
The Breast Journal.2020; 26(9): 1659. CrossRef
Development and validation of a nomogram incorporating axillary lymph node ratio to predict survival in node-positive breast cancer patients after neoadjuvant chemotherapy
Jianguo Lai, Zihao Pan, Peixian Chen, Guolin Ye, Kai Chen, Fengxi Su
Japanese Journal of Clinical Oncology.2019; 49(1): 22. CrossRef
Lymph node ratio as an alternative to pN staging for predicting prognosis after neoadjuvant chemotherapy in breast cancer
Dong Hui Cho, Soo Youn Bae, Ji Young You, Hong Kyu Kim, Young Woo Chang, Yoo Jin Choi, Sang Uk Woo, Gil Soo Son, Jae Bok Lee, Jeoung Won Bae, Seung Pil Jung
The Kaohsiung Journal of Medical Sciences.2018; 34(6): 341. CrossRef
Ganglio secundario como indicador de linfadenectomía axilar en pacientes afectas de cáncer de mama
Manel Cremades, Mireia Torres, Montse Solà, Jordi Navinés, Icíar Pascual, Antonio Mariscal, Albert Caballero, Eva Castellà, Miguel Ángel Luna, Joan Francesc Julián
Cirugía Española.2017; 95(9): 536. CrossRef
Secondary Node Analysis as an Indicator for Axillary Lymphadenectomy in Breast Cancer Patients
Manel Cremades, Mireia Torres, Montse Solà, Jordi Navinés, Icíar Pascual, Antonio Mariscal, Albert Caballero, Eva Castellà, Miguel Ángel Luna, Joan Francesc Julián
Cirugía Española (English Edition).2017; 95(9): 536. CrossRef
Risk factors of locoregional relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy following mastectomy and radiotherapy
Liang Huang, Sheng Chen, Wentao T. Yang, Zhiming Shao
Oncotarget.2017; 8(24): 39703. CrossRef
Lymph Node Ratio Analysis After Neoadjuvant Chemotherapy is Prognostic in Hormone Receptor-Positive and Triple-Negative Breast Cancer
Jacqueline Tsai, Danielle Bertoni, Tina Hernandez-Boussard, Melinda L. Telli, Irene L. Wapnir
Annals of Surgical Oncology.2016; 23(10): 3310. CrossRef
Number of negative lymph nodes as a prognostic factor for ypN0-N1 breast cancer patients undergoing neoadjuvant chemotherapy
Fei Xin, Yue Yu, Zheng-Jun Yang, Li-Kun Hou, Jie-Fei Mao, Li Xia, Xin Wang, Xu-Chen Cao
Tumor Biology.2016; 37(6): 8445. CrossRef

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Ovarian Ablation Using Goserelin Improves Survival of Premenopausal Patients with Stage II/III Hormone Receptor-Positive Breast Cancer without Chemotherapy-Induced Amenorrhea: Juan Zhou, San-Gang Wu, Jun-Jie Wang, Jia-Yuan Sun, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Zhen-Yu He; Cancer Res Treat. 2015;47(1):55-63. Published online August 21, 2014; DOI: https://doi.org/10.4143/crt.2013.165

Abstract PDF PubReader ePub

Purpose
The purpose of this study was to assess the value of ovarian ablation using goserelin in premenopausal patients with stage II/III hormone receptor-positive breast cancer without chemotherapy-induced amenorrhea (CIA). Materials and Methods We retrospectively reviewed the data of breast patients treated between October 1999 and November 2007 without CIA. The Kaplan-Meier method was used for calculation of the survival rate. Log rank method and Cox regression analysis were used for univariate and multivariate prognostic analysis. Results The median follow-up period was 61 months. Initially, 353 patients remained without CIA after chemotherapy and 98 among those who received goserelin and tamoxifen (TAM). In univariate analysis, goserelin improved locoregional recurrence-free survival (LRFS) (98.9% vs. 94.1%, p=0.041), distant metastasis-free survival (DMFS) (85.4% vs. 71.9%, p=0.006), disease-free survival (DFS) (85.4% vs. 71.6%, p=0.005), and overall survival (OS) (93.5% vs. 83.5%, p=0.010). In multivariate analysis, goserelin treatment was an independent factor influencing DMFS (hazard ratio [HR], 1.603; 95% confidence interval [CI], 1.228 to 2.092; p=0.001), DFS (HR, 1.606; 95% CI, 1.231 to 2.096; p=0.001), and OS (HR, 3.311; 95% CI, 1.416 to 7.742; p=0.006). In addition, treatment with goserelin resulted in significantly improved LRFS (p=0.039), DMFS (p=0.043), DFS (p=0.036), and OS (p=0.010) in patients aged < 40 years. In patients aged ≥ 40 years, goserelin only improved DMFS (p=0.028) and DFS (p=0.027). Conclusion Ovarian ablation with goserelin plus TAM resulted in significantly improved therapeutic efficacy in premenopausal patients with stage II/III hormone receptor-positive breast cancer without CIA.

Citations

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An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis
Akmaral Baspakova, Afshin Zare, Roza Suleimenova, Aidar B. Berdygaliev, Bibigul Karimsakova, Kymbat Tussupkaliyeva, Nadiar M. Mussin, Kulyash R. Zhilisbayeva, Nader Tanideh, Amin Tamadon
Molecular Aspects of Medicine.2025; 101: 101336. CrossRef
Adjuvant ovarian function suppression and tamoxifen in premenopausal breast cancer patients: A meta-analysis
Hamdy A. Azim, Kyrillus S. Shohdy, David F. Kaldas, Loay Kassem, Hatem A. Azim
Current Problems in Cancer.2020; 44(6): 100592. CrossRef
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Valentine D. Verpaalen, J. Brad Case, Michael J. Dark, S. Joel Cardenas-Goicoechea, Matt D. Winter, Sarah E. Boston, Fernando Garcia-Pereira, Alice S. Rhoton-Vlasak, Beau B. Toskich
American Journal of Veterinary Research.2020; 81(9): 747. CrossRef
Breast cancer in young patients. Peculiarities of prognosis and adjuvant hormone therapy (a literature review)
D. N. Kravchenko, A. A. Parokonnaya, M. I. Nechushkin, E. A. Nikitina, N. D. Hakurinova
Tumors of female reproductive system.2018; 14(3): 55. CrossRef
Evaluating the Survival Benefit Following Ovarian Function Suppression in Premenopausal Patients with Hormone Receptor Positive Early Breast Cancer
Lin Qiu, Fangmeng Fu, Meng Huang, Yuxiang Lin, Yazhen chen, Minyan Chen, Chuan Wang
Scientific Reports.2016;[Epub] CrossRef
Evaluation of a Survivorship Care Plan: Long-Term Use, Care Coordination and Quality of Life in Breast Cancer Survivors
Meagan E Brennan, Frances M Boyle, Phyllis N Butow, Andrew J Spillane
Breast Cancer Management.2015; 4(3): 145. CrossRef
More Options for Fertility Preservation for Patients With Cancer
Pamela N. Munster
Journal of Clinical Oncology.2015; 33(22): 2413. CrossRef

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