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36 "Dong Young Noh"
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Original Articles
The Relationship between Expression of the Sodium/iodide Symporter Gene and the Status of Hormonal Receptors in Human Breast Cancer Tissue
Hyun Jung Oh, June-Key Chung, Joo Hyun Kang, Won Jun Kang, Dong Young Noh, In Ae Park, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee
Cancer Res Treat. 2005;37(4):247-250.   Published online August 31, 2005
DOI: https://doi.org/10.4143/crt.2005.37.4.247
AbstractAbstract PDFPubReaderePub
Purpose

It has been reported that the sodium/iodide symporter (NIS) gene is expressed in several breast cancer tissues, suggesting the possibility of radionuclide imaging and therapy. However, the regulatory mechanism of NIS gene expression in breast cancer is not yet understood. To assess the relationship between the hormonal status and the NIS expression in breast cancer tissue, we investigated the NIS expression and correlated it to the expression of the thyrotropin receptor (thyroid stimulating hormone receptor, TSH-R), the estrogen receptor (ER) and the progesterone receptor (PR) in human breast cancer tissues.

Materials and Methods

Breast cancer tissues were obtained from 44 patients. Pathological examination showed 2 cases of Grade I, 17 of Grade II, 22 of Grade III, and 3 of unknown grade. We measured the expression of NIS and TSH-R genes by using RT-PCR and we measured the status of ER and PR by using immunohistochemistry.

Results

The NIS gene was expressed in 15 (34%) of the 44 breast cancer tissues. The NIS gene was expressed in 32% of the cases with TSH-R gene expression. The NIS gene was expressed in 40% of the breast cancer tissues with a positive PR and in 31% with a negative PR (p>0.05). It was positive for PR in 18% of the cases and negative for PR in 39% of the cases (p>0.05).

Conclusion

The NIS gene is expressed in approximately one-third of the human breast cancer tissues. Its expression was not related to the presence of the TSH-R gene or hormonal receptors, ER and PR.

Citations

Citations to this article as recorded by  
  • Benign thyroid disease and the risk of breast cancer: An updated systematic review and meta-analysis
    Mingyue Han, Yao Wang, Yuanhui Jin, Xue Zhao, Haiying Cui, Guixia Wang, Xiaokun Gang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions
    Man Lu, Hanqing Liu, Bilian Zheng, Shengrong Sun, Chuang Chen
    Cancers.2022; 14(20): 5117.     CrossRef
  • Competitive Endogenous Role of the LINC00511/miR-185-3p Axis and miR-301a-3p From Liquid Biopsy as Molecular Markers for Breast Cancer Diagnosis
    Marwa M. Mahmoud, Eman F. Sanad, Reham A.A. Elshimy, Nadia M. Hamdy
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • The correlation between breast cancer and urinary iodine excretion levels
    Fatma Umit Malya, Huseyin Kadioglu, Mustafa Hasbahceci, Kemal Dolay, Mehmet Guzel, Yeliz Emine Ersoy
    Journal of International Medical Research.2018; 46(2): 687.     CrossRef
  • Different expression of sodium–iodide importer (NIS) between lactating breast and thyroid tissues may be due to structural difference of thyroid-stimulating hormone receptor (TSHR)
    X.-Z. Shi, L. Xue, X. Jin, P. Xu, S. Jia, H.-M. Shen
    Journal of Endocrinological Investigation.2017; 40(1): 41.     CrossRef
  • Is there an association between thyroid function abnormalities and breast cancer?
    Anna Angelousi, Evanthia Diamanti-Kandarakis, Evangelia Zapanti, Afroditi Nonni, Eftuxios Ktenas, Aimilia Mantzou, Konstantinos Kontzoglou, Grigorios Kouraklis
    Archives of Endocrinology and Metabolism.2017; 61(1): 54.     CrossRef
  • Iodide transport and breast cancer
    Vikki L Poole, Christopher J McCabe
    Journal of Endocrinology.2015; 227(1): R1.     CrossRef
  • The prognosis and treatment of primary thyroid cancer occurred in breast cancer patients: comparison with ordinary thyroid cancer
    Chang Min Park, Young Don Lee, Eun Mee Oh, Kwan-Il Kim, Heung Kyu Park, Kwang-Pil Ko, Yoo Seung Chung
    Annals of Surgical Treatment and Research.2014; 86(4): 169.     CrossRef
  • Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer
    Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti, Diego Russo
    BMC Cancer.2014;[Epub]     CrossRef
  • TSH receptor antibodies have predictive value for breast cancer – retrospective analysis
    Paweł Szychta, Wojciech Szychta, Adam Gesing, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
    Thyroid Research.2013;[Epub]     CrossRef
  • Quantitative Immunohistochemical Analysis Reveals Association between Sodium Iodide Symporter and Estrogen Receptor Expression in Breast Cancer
    Sushmita Chatterjee, Renu Malhotra, Frency Varghese, Amirali B. Bukhari, Asawari Patil, Ashwini Budrukkar, Vani Parmar, Sudeep Gupta, Abhijit De, Pranela Rameshwar
    PLoS ONE.2013; 8(1): e54055.     CrossRef
  • Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer
    Sasha J Beyer, Xiaoli Zhang, Rafael E Jimenez, Mei-Ling T Lee, Andrea L Richardson, Kun Huang, Sissy M Jhiang
    BMC Research Notes.2011;[Epub]     CrossRef
  • Do cell surface trafficking impairments account for variable cell surface sodium iodide symporter levels in breast cancer?
    S. J. Beyer, R. E. Jimenez, C. L. Shapiro, J. Y. Cho, S. M. Jhiang
    Breast Cancer Research and Treatment.2009; 115(1): 205.     CrossRef
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The Estimation of Breast Cancer Disease-Probability by Difference of Individual Susceptibility
Sue Kyung Park, Keun Young Yoo, Dae Hee Kang, Sei Hyun Ahn, Dong Young Noh, Kuk Jin Choe
Cancer Res Treat. 2003;35(1):35-51.   Published online February 28, 2003
DOI: https://doi.org/10.4143/crt.2003.35.1.35
AbstractAbstract PDF
PURPOSE
The aims were to evaluate the main risk factors (RFs) of breast cancer and to estimate the individual disease-probability from combinations of RFs in Korean female. MATERIALS AND METHODS: We conducted case-control study of 1, 687 incident cases of invasive carcinoma and 1, 238 controls during 1996~2000. A breast cancer disease-probability model was established by a general modeling process using a multivariate logistic regression model, which included the main Korean RFs and synergistic interaction-terms. RESULTS: The main Korean RFs selected were age, family history of second relatives, BMI, age at first full term pregnancy, breast-feeding, and a special test on the breasts. Two synergisms were observed between age and breast-feeding, and between special test and age at first fullterm pregnancy. The disease-probability and model are shown in Table 4, and Appendix 1. CONCLUSION: The availability of previous Western models was limited for Korean female due to the differences inhazard-rates and the characteristics of breast cancer between Asian and Western females. Due to limited basic data, i.e. incidence, hazard-rate and cancer-cohorts, the developing-probability of breast cancer for Korean females was not calculated. Therefore, the disease-probability was calculated instead. This approach might be more beneficial for Koreans, and help in the decision- making for regular screening or hospital visit-interval, counseling in breast-cancer clinics, prescribing high-risk population, and in educating for primary prevention, although it over-estimates the relative probability compared to the developing-probability and the 65% predictive validity.

Citations

Citations to this article as recorded by  
  • Validating Breast Cancer Risk Prediction Models in the Korean Cancer Prevention Study-II Biobank
    Yon Ho Jee, Chi Gao, Jihye Kim, Seho Park, Sun Ha Jee, Peter Kraft
    Cancer Epidemiology, Biomarkers & Prevention.2020; 29(6): 1271.     CrossRef
  • Bone mineral density and the risk of breast cancer: a case-control study of Korean women
    Bo-Kyoung Kim, Yoon-Ho Choi, Yun-Mi Song, Joo-Hyun Park, Hye-Mi Noh, Tuong L. Nguyen, John L. Hopper
    Annals of Epidemiology.2014; 24(3): 222.     CrossRef
  • Breast cancer screening rates-related factors Korea women ever considering area environmental characteristics: The fourth Korea National Health and Nutrition Examination Survey(KNHANES IV)
    Mi-Hwa Lee, Sang-Hyun Kim
    Journal of Digital Convergence.2014; 12(11): 437.     CrossRef
  • Validation of Risk Assessment Models for Predicting the Incidence of Breast Cancer in Korean Women
    Jun Won Min, Myung-Chul Chang, Hae Kyung Lee, Min Hee Hur, Dong-Young Noh, Jung Han Yoon, Yongsik Jung, Jung-Hyun Yang
    Journal of Breast Cancer.2014; 17(3): 226.     CrossRef
  • Estimated risks and optimistic self-perception of breast cancer risk in Korean women
    ChaeWeon Chung, Suk Jeong Lee
    Applied Nursing Research.2013; 26(4): 180.     CrossRef
  • Korean Risk Assessment Model for Breast Cancer Risk Prediction
    Boyoung Park, Seung Hyun Ma, Aesun Shin, Myung-Chul Chang, Ji-Yeob Choi, Sungwan Kim, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kang, Keun-Young Yoo, Sue K. Park, Todd W. Miller
    PLoS ONE.2013; 8(10): e76736.     CrossRef
  • The proper approaches for breast disease
    Jihoon Yu, Intaek Hwang
    Korean Journal of Obstetrics.2011; 54(2): 67.     CrossRef
  • Factors Affecting Periodic Screening Behaviors for Breast Cancer among Hospital Nurses
    Suk Ok Lee, Eun Soon Sim, Sukhee Ahn
    Korean Journal of Women Health Nursing.2010; 16(4): 390.     CrossRef
  • Epidemiologic Characteristics of the Breast Cancer in Korea
    Sue K Park, Daehee Kang, Yeonju Kim, Keun-Young Yoo
    Journal of the Korean Medical Association.2009; 52(10): 937.     CrossRef
  • Implications of Systematic Review for Breast Cancer Prediction
    Sun-Mi Lee, Jin-Hee Park, Han-Jong Park
    Cancer Nursing.2008; 31(5): E40.     CrossRef
  • Breast cancer risk factors in Korean women: a literature review
    S.‐M. Lee, J.‐H. Park, H.‐J. Park
    International Nursing Review.2008; 55(3): 355.     CrossRef
  • The Loss of P16ink4Expression is Strongly Associated with Hypermethylation-Related Inactivation in Breast Carcinoma
    Gyungyub Gong, Mi-Jung Kim, Yhong-Hee Shim, Gyeong Hoon Kang, Sei Hyun Ahn, Jae Y. Ro
    Journal of Breast Cancer.2006; 9(2): 84.     CrossRef
  • Epidemiology and Risk Factors of Breast Cancer
    Keun-Young Yoo
    Journal of the Korean Medical Association.2003; 46(6): 482.     CrossRef
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Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk
Sook Un Kim, Kyoung Mu Lee, Sue Kyung Park, Keun Young Yoo, Dong Young Noh, Kook Jin Choe, Se Hyun Ahn, Daehee Kang
Cancer Res Treat. 2002;34(3):205-211.   Published online June 30, 2002
DOI: https://doi.org/10.4143/crt.2002.34.3.205
AbstractAbstract PDF
PURPOSE
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
RESULTS
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
CONCLUSION
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.

Citations

Citations to this article as recorded by  
  • Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
    Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass
    BMC Cancer.2014;[Epub]     CrossRef
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Correlation of GLUT-1 Expression and F-18-FDG Uptake on Positron Emission Tomography in Breast Carcinoma
Gi Jeong Cheon, June Key Chung, Bo Kwang Kim, Yong Jin Lee, Dong Young Noh, Ja June Jang, Jeong Seok Yeo, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee
J Korean Cancer Assoc. 2000;32(6):1067-1074.
AbstractAbstract PDF
PURPOSE
Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has been proven to be useful in the detection of breast cancer. However, the degree of FDG uptake was variable. In this study, we evaluated the relationship between glucose transporter-1 (GLUT-1) expression with the FDG uptake in patients with breast cancer.
MATERIALS AND METHODS
15 patients with proven breast cancer underwent F-18-FDG PET. After surgical resection, anti-GLUT-1 immunohistochemical staining was performed in tumor tissues to measure the GLUT-1 expression. We evaluated the correlation between semi-quantitative FDG uptake by standardized uptake value (SUV) and GLUT-1 expression.
RESULTS
In total 15 patients, there was no significant correlation between SUV and GLUT-1 expression. We separated the patients into two groups according to the tumor size. In the group of large tumor (short diameter > or =2 cm), there was no significant correlation. However, in the group of small tumor (short diameter <2 cm), there was a significant correlation between the FDG uptake and GLUT-1 expression (rho=0.812, p=0.047).
CONCLUSION
GLUT-1 expression can influence the FDG uptake in the small breast cancers. For large breast cancers, other factors as well as GLUT-1 expression may influence the FDG uptake.
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The Role of bcl-2 and p53 in Tamoxifen-Induced Apoptosis of Human Breast Cancer Cell Lines
Woo Chul Noh, Dong Young Noh, Yong Ho Ham, Chang Min Kim, Nam Sun Paik, Nan Mo Moon, Kuk Jin Choe
J Korean Cancer Assoc. 2000;32(3):531-538.
AbstractAbstract PDF
PURPOSE
Tamoxifen has been well known as an effective anti-tumor agent against breast cancer. The important role of bcl-2 and p53 proteins in tamoxifen-induced apoptosis of breast cancer cells has been suggested. However, the paradoxical fact that bcl-2 over-expression is assdegrees Ciated with better prognosis in clinic has not yet been clearly explained. To investigate this paradox, we analyzed the effect and dynamics of bcl-2 and p53 on the apoptosis after treatment of breast cancer cells with tamoxifen.
MATERIALS AND METHODS
The human breast cancer cell lines MCF-7 and MB MDA-468 were treated with 17-betaestradiol (E2) and tamoxifen.
RESULTS
Following tamoxifen treatment, MCF-7 cells underwent apoptosis accompanied by reduced bcl-2 expression. E2 pre-treatment led to the inhibition of tamoxifen-mediated apoptosis and bcl-2 down-regulation. When MB MDA-468 cells were treated with E2 or tamoxifen, bcl-2 and p53 protein expression did not change and apoptosis did not develop.
CONCLUSION
We observed that the down-regulation of bcl-2 by tamoxifen treatment can facilitate the apoptosis of breast cancer cells without p53 mutations. This finding was consistent with clinical experiences in which bcl-2 positive tumors were assdegrees Ciated with more indolent phenotypes in breast cancer.
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Clinical Analysis of Malignant Pheochromocytoma
Seung Eun Choi, Young Cheol Kim, Tae Seon Kim, Dong Young Noh, Yeo Kyu Youn, Kuk Jin Choe, Seung Keun Oh
J Korean Cancer Assoc. 1999;31(6):1307-1314.
AbstractAbstract PDF
PURPOSE
There are no specific clinical and histopathologic characteristics of malignant pheochromocytoma and the optimal treatment modality has not been established yet. We analyzed the clinical and histopathologic features of malignant pheochromocytoma and treatment results.
MATERIALS AND METHODS
We reviewed the clinical records of 10 patients with malignant pheochromocytoma diagnosed at Seoul National University Hospital from March 1987 to June 1998.
RESULTS
Nine of 10 (90%) patients had functional tumors. The biochemical laboratory findings showed elevated 24-hour urine VMA level in nine patients available. The median size of the tumors was 11x11 cm. Six of 10 (60%) patients were initially diagnosed as malignant tumors because of direct invasions to adjacent tissues or distant metastases. On the other hand, remaining 4 patients were initially diagnosed as benign, but the distant metastases developed metachronously after resection of the primary lesion. The median duration between the initial operation and the detection of metastases was 57 months (range: 47~72 months) in these patients. The liver was the most common site of metastases (60%). With regards to the histopathological features, most of the tumors (87.5%) showed capsulation, necrosis and hemorrhage. The findings of lymphatic invasion, angio-invasion, and mitosis were found in 62.5% of the cases. All but 2 patients were initially treated with radical operation for the primary lesions. The disease recurrences or metastases occurred in 7 out of 10 patients. Of these, 4 patients were treated with chemotherapy or interferon- a after recurrences. Overall, the median survival for all patients was 82 months (range: 37~143 months). Two patients is alive and only one patient is alive without recurrence.
CONCLUSION
The careful follow-up for at least 5 years and the aggressive multi-disciplinary therapy may be needed for the diagnosis and the management of malignant pheochromocytoma.
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The Predictors of Axillary Node Metastasis in 2 cm or Less Breast Cancer
Han Sung Kang, Dong Young Noh, Oh Joong Kwon, Yeo Kyu Youn, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1999;31(6):1188-1194.
AbstractAbstract PDF
PURPOSE
Axillary node involvement is the single most important prognostic variable in patients with breast cancer. If axillary lymph node status of breast cancer patients could be accurately predicted from basic clinical information and from characteristics of their primary tumors, many patients could be spared axillary lymph node dissection. With the availability of numerous histologic prognosticators and new immunochemical prognostic indicators, it is reasonable to reconsider the necessity of axillary node dissection for lesions more advanced than duct carcinoma in situ.
MATERIALS AND METHODS
Six hundred fifty-six patients with Tl invasive breast cancer were evaluated. All the patients underwent axillary dissection, and the pathologic status of the nodes was known. The parameters of the primary tumor in this study were age, size, family history, tumor palpability, nuclear and histological grade, hormone receptor status, lymphatic vessel invasion (LVI), and various tumor markers (bc1-2, cathepsinD, c-erbB2, E-cadherin, p53).
RESULTS
Approximately 31% of the 656 patients with Tl breast carcinoma had axillary node metastasis. Four factors were identified as significant predictors of node metastasis: age 35 or less (p=0.01), lymphatic vessel invasion (p < 0.01), tumor palpability (p=0.02), and tumor size (p<0.01). However, independent predictors of lymph node metastasis in the multivariate logistic regression analyses were tumor size (p=0.04) and LVI (p=0.03).
CONCLUSION
Characteristics of the primary tumor can help assess the risk for axillary lymph node metastases in Tl breast cancer. Selected patients who have 1cm or less without lymphatic vessel invasion are considered to be at minimal risk of axillary node metastasis and might be spared routine axillary dissection.
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A Case-Control Study of the Association between Glutathione S-transferase (GST) M1 and T1 Genetic Polymorphism and Breast Cancer in Korean Women: Preliminary report
Sue Kyung Park, Dae Hee Kang, Byung Joo Park, Seung Joon Lee, Young Chul Kim, Han Sung Kang, Jun Suk Suh, Se Hyun Ahn, Dong Young Noh, Kuk Jin Choe
J Korean Cancer Assoc. 1999;31(4):653-662.
AbstractAbstract PDF
PURPOSE
A hospital-based case-control study was conducted to evaluate the role of glutathione-S-transferase (GST) Ml and Tl genetic polymorphism for developing breast cancer in Korea.
MATERIALS AND METHODS
Histologically confirmed incident cases of breast cancer (n=176) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital (SNUH), Borame hospital, and Asan Medical Center from 1994 to 1998. Women with no self-reporting past history of any malignancies who were selected from the inpatients at the same department at three hospitals during the same period served as controls (n 118). Information on the life-styles including reproductive factors were obtained by interview using questionnaire. Age and education adjusted odds ratio and 95% confidence interval were estimated by unconditional linear logistic regression.
RESULTS
These subjects had similar risk factors for developing breast cancer to general Korean population based on other epidetniologic studies previously performed in Korea. GSTI1 null type showed a borderline significance relation in the breast cancer risk (adjusted OR=1.6, 95% CI=0.96-2.62), however, GSTM1 null type was not significant (adjusted OR=1.1, 95% CI=0.67-1.80). Particularly noteworthy was an borderline increasing tendency (p<0.1) of the breast cancer risk with the risk null genotypes assessed by multivariate logistic regression model after adjusting age and education: the putative low-risk genotype with both GSTM1 & GSTT1 wild type, OR=1.0; one putative high risk genotype with GSTM1 null or GSTMl null type, OR=1.9 (95% CI=0.92-3.74); all two putative high risk genotype with both GSTM1 & GSTT1 null type, OR=2.0 (95% CI=0.89-4.68).
CONCLUSIONS
These findings suggest that both GSTMl and GSTT1 null type might be the risk factor of developing breast cancer in Korean women. Further investigation with larger sample size should be needed to provide more concrete information on the role of GST genetic polymorphism in breast cancer.
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A Clinical Study of Infiltrating Lobular Breast Cancer
Jung Mo Kim, Young Chul Kim, Dong Young Noh, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1999;31(1):90-97.
AbstractAbstract PDF
PURPOSE
Infiltrating lobular carcinoma of the breast was known to have a high incidence of multicentricity and bilaterality in patients. We analyzed the clinical features of infiltrating lobular breast cancer.
MATERIALS AND METHODS
We studied 29 patients with infiltrating lobular carcinoma of the breast, from Jan. 1980 to Mar. 1997 in the Department of Surgery, Seoul National University Hospital.
RESULTS
The age of the patients ranged from 32 to 71 years with an average of 45.2 years. The main complaining symptom was a painless mass. The diameter of the tumor ranged from 0.7 to 7 cm with a mean size of 2.8 cm. The axillary lymph node was positive for malignancy in 12 cases. The number of multicentric breast cancers were 7 cases (24.1%), and the number of bilateral breast cancers were 3 cases (10.3%). The estrogen receptor was positive in 66.7%, and the progesterone receptor was positive in 75% of the cases. There were one local recurrence and three distant metastases during a mean follow-up period of 4.5 years. The 5-year survival rate and 5-year disease free survival rate were 89.6% and 88.6%, respectively.
CONCLUSION
Infiltrating lobular breast cancers are at greater risk of developing multicentricity and bilaterality than nonlobular breast cancers. Careful program of frequent follow-up examinations and thorough histopathological studies are needed for patients with infiltrating lobular breast cancers.
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The Expression of Phospholipase C-gamma1 and Its Cellular Characteristics
Dong Young Noh, Han Sung Kang, Young Chul Kim, In Ae Park, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1998;30(3):457-463.
AbstractAbstract PDF
BACKGROUND
The activation of phospholipase C(PLC) is one of the early cellular events in various growth process, including malignant transformation. PLC-gamma1 is activated through direct interaction with growth factor receptor tyrosine kinase. MATERIAL AND METHODS: Using immunoblot assay, we evaluated overexpression of PLC-gamma1 expression in twenty human breast cancer tissues. It was also determined whether there was any connection between other prognostic factors(numbers of metastatic axillary nodes, nuclear and histological grade, c-erbB2, p53 and E-cadherin) and the overexpression of PLC-gamma1 protein.
RESULTS
Seventeen of 20 breast cancer tissues showed overexpression of PLC-gamma1, which was corresponded to that seen on the immunohistochemistry( kappa= 0.8275, p = 0.003). Of 3 tumor markers, immunohistochemically determined, positive expression of E-cadherin only was associated with PLC-gamma1 protein overexpression in a range of statistical significance (p=0.045, kappa=0.607).
CONCLUSION
PLC-gamma1 overexpression might be pathogenic trigger involved in breast cancer and the relationship between expression of E-cadherin and PLC-gamma1 would require further elucidation.
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High Risk Group for Female Breast Cancer in Korea
Keun Young Yoo, Sue Kyung Park, Joohun Sung, Daehee Kang, Young Cheol Kim, Han Sung Kang, Jun Suk Suh, Jee Soo Kim, Ik Jin Yun, Sehwan Han, Dong Young Noh, Kyk Jin Choe
J Korean Cancer Assoc. 1998;30(3):435-449.
AbstractAbstract PDF
PURPOSE
A hospital-based case-control study was conducted to find out risk factors for developing breast cancer in Korea.
MATERIALS AND METHODS
Histologically confirmed incident cases of breast cancer(n=280) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital during 1994 to 1997. Women with free of self-reporting past history of any malignancies were regarded as controls who were selected from the inpatients at the Department of Obstetrics and Gynecology of the same hospital during 1992 to 1994(n=930). Information on life-styles including reproductive factors were obtained by direct interview using questionnaire. Age- and education-adjusted odds ratio and 95% confidence interval were estimated by unconditional linear logistic regression.
RESULTS
Based on the risk factors identified by both this study and other epidemiologic studies previously performed in Korea, high risk group for female breast cancer in Korea was established as follows. (1) women with age over 50, (2) women who have a family history of breast cancer, (3) women with age at menarche before 14-year old, (4) women with age at menopause after 50-year old, (5) women who were not experienced a full term pregnancy, (5) nulliparous women (6) women with age at her first fullterm pregnancy after 35-year old (7) women who were not experienced breast feeding, (8) women with body mass index more than 25 kg/m2 or with body weight more than 64 kg.
CONCLUSION
Life-time risk of breast cancer, as an indicator of absolute risk, according to the risk factors should be pursued in further prospective studies with community population.
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Retroperitoneal Sarcoma
Ji Soo Kim, Won Shik Han, Dong Young Noh, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1998;30(2):370-377.
AbstractAbstract PDF
PURPOSE
To determine the clinical feature, surgical management of primary and recurrent disease, predictive factors for outcome, and impact of multimodality therapy in retroperitoneal sarcoma.
MATERIALS AND METHODS
60 patients were confirmed pathologically as soft-tissue sarcoma of the retroperitoneum by operation or needle biopsy in Seoul National University Hospital from 1983 to 1995. A retrospective analysis was performed.
RESULTS
The abdominal mass was common presenting symptom. Histologically liposarcomas(25%) and leiomyosarcomas(23.3%) were most common, and MFHs(11.7%) and malignant schwannomas(11.7%) followed. The overall 5 year survival rate was 54.6%. Complete resection was possible in 51.7% of patients and strongly predicts outcome (<0.0001). These patients had a median survival of 130 months compared to 20 months for those undergoing partial resection and 9 months for those with unresectable tumors. 11(35%) of completely resected patients have had local recurrence. These patients underwent reoperation when feasible. Complete resection of recurrent disease was performed in 10 patients(90%), with a 42 months median survival time after reoperation. Resection of adjacent organ was performed in 19 patients. 14 of these were completely resected, and showed 100% of 5 year survival rate. Tumor grade was not a significant predictor of outcome. Gender, histologic type, encapsulation, stage, resectability, combined resection were significant prognostic factors by univariate analysis. But resectability was only independent prognostic factor on mutivariate analysis. Radiation therapy and chemotherapy could not be shown to have significant impact on survival.
CONCLUSION
Complete resection is the most important prognostic factor of retroperitoneal sarcoma. Extensive and aggressive surgery must be considered including resection of adjacent organs. Multiple resection seems to improve survival in recunent cases.
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Breast Cancer of 35 Years Old or Less
Han Sung Kang, Han Kwang Yang, Dong Young Noh, Yeo Kyu Yong, Sang Joon Kim, Seung Keun Oh, Kuk Jin Choe, Jin Pok Kim
J Korean Cancer Assoc. 1998;30(2):262-271.
AbstractAbstract PDF
PURPOSE
The age of onset of Korean breast carcinoma is younger than that in western countries by some 10 years, thus the criteria of young age in manuscript from western countries cannot reflect the characteristics of young breast cancer properly in Korea.
MATERIALS AND METHODS
We studied 290 breast cancer patients, 35 years old or younger retrospectively, from Jan. 1980 to Dec. 1995 in the Department of Surgery, Seoul National University Hospital. The age criteria of 30 and 35 years was utilized to define two groups.
RESULTS
The group(age< or =35) had larger primary tumors, more metastatic lymph nodes, and worse stages than older counterpart(p=0.015, 0.0066, 0.0329 respectively). They had worse disease-free survival but not overall survival(p=0.0312, 0.2427 respectively). The other group(age < or =30) showed significantly worse outcome in overall as well as disease free survival(p=0.0056, 0.0013) compared to the group(age>30). When we compared the group of age< or =30 to that of 31< or = age < or =35, there was statistically significant difference in primary tumor size, axillary nodal status and pathological stage(p=0.023, 0.019, 0.022 respectively).
CONCLUSION
The age of 30 might be better criteria to define young age as prognostic factor rather than age of 35 in Korea.
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Germline Mutation of BRCA2 Gene in Korean Breast / Ovarian Cancer Families
Yong Jin Won, Jae Hwan Oh, Ji Hyun Kim, Dong Young Noh, Kuk Jin Choe, Soon Beom Kang, Lee Su Kim, Man Su Ro, Nam Sun Paik, Dae Hyun Yang, Se Min Oh, Soon Nam Lee, Kyung Kook Kim, Jae Gahb Park
J Korean Cancer Assoc. 1998;30(2):242-252.
AbstractAbstract PDF
PURPOSE
Recent discovery of BRCA1 and BRCA2 genes has made it possible to perform presymptomatic diagnosis in hereditary breast/ovarian cancer families. We have previously reported germline mutations of the BRCA1 gene in Korean hereditary breast/ovarian cancer families. In that study two out of 13 families were found to have germline mutations in BRCA1 gene. One was a nonsense mutation in codon 1815, and the other was a frameshift mutation due to 2 base-pair deletion in codon 1701 of BRCA1 gene. This study was intended to identify germline mutations of the BRCA2 gene in Korean breast/ovarian cancer families.
MATERIALS AND METHODS
Peripheral blood DNA was obtained from 10 breast cancer patients registered at the Korean Hereditary Tumor Registry with positive family history of breast and/or ovarian cancer. Exons 11 and 27 of the BRCA2 gene(together accounting for 50% of the coding region of the BRCA2 gene) were amplified by polymerase chain reaction(PCR) and screened for mutations by in vitro transcription/translation method. For confirmation of the mutations, automatic sequencing of the PCR products displaying abnormal truncated protein bands was perfomed.
RESULT
We identified an abnormal truncated protein in the exon 11 of the BRCA2 gene from a member of hereditary breast cancer family, SNU-B4. Sequencing analysis revealed a 4 bp deletion in codons 1248-49 of the exon 11, resulting in frameshift that led to premature stop codon and truncation of the protein product.
CONCLUSION
We have identified a germline mutation from a Korean hereditary breast cancer family. So far only one case of the same mutation has been registered in Database of BRCA2 mutation (BIC) by a commercial genetic diagnosis company, Myriad Genetics, Inc. Identification of the germline mutation in BRCA2 gene should aid in the accurate presymptomatic diagnosis of the at-risk members in this family.
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Clinical Review of Familial and Hereditary Breast Cancer
Young Joon Ahn, Han Sung Kang, Ji Soo Kim, Dong Young Noh, Yeo Kyu Youn, Jae Gahb Park, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1998;30(1):119-126.
AbstractAbstract PDF
PURPOSE
Family history of breast cancer can increase woman's risk of having the disease two to threefold. Patients with familial breast cancer affect the younger at diagnosis and have higher frequency of bilateral disease than those with sporadic cases. We evaluated the characteristics of familial breast cancer(FBC) patients including hereditary breast cancer(HBC) and compared those to sporadic breast cancer(SBC). MATERIALS & METHODS: Of the 885 patients operated on for breast cancer from January 1991 to December 1995 in Seoul National University hospital, 18 patients(2.0%) were classified as familial breast cancer and 5 patients as hereditary breast cancer by definition.
RESULTS
The mean age of the patients was 45.7 years in FBC, 47.0 years in HBC and 46.8 years in SBC. The bilateral disease were more frequent in family history positive group(FBC; 22.2%, HBC; 60%) than SBC(1.5%) (p<0.01). In this series, there were no statistical differences in the age at onset, tumor location, histopathologic types and clinical stages amomg the different groups of the breast cancer, but bilateral cancer were seen more often in the familial history positive group than the other groups.
CONCLUSION
As the frequency of familial and hereditary breast cancer was relatively low compared to that seen in other western countries, it would be necessary for the physician to inquire the family history of pateints with the breast cancer more carefully.
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Clinicopathologic Analysis of 40 Mucinous Breast Carcinomas
Woo Jin Choe, Han Sung Kang, Ji Soo Kim, Dong Young Noh, In Ae Park, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe
J Korean Cancer Assoc. 1998;30(1):106-112.
AbstractAbstract PDF
PURPOSE
Mucinous carcinoma of breast was known to have a lower lymph node metastasis and better prognosis than other type of breast cancer. This study was performed to clarify the clinicopathologic features and prognosis of mucinous breast carcinoma.
MATERIALS AND METHODS
We reviewed clinicopathologic features of 40 patients diagnosed mucinous breast carcinoma from Jan. 1985 to Dec. 1995 and compared 31 patients of unmixed mucinous breast carcinoma with 1128 patients of infiltrating ductal carcinoma group.
RESULTS
Of total 40 mucinous ca., 31 cases were unmixed type showing no component of invasive ductal component(IDC) and 9 cases were mixed type showing IDC. The average age of the patients was 47 ranging from 31 to 71 years. The most common symptom was palpable breast mass(38 cases, 95%). According to TNM classification, the numbers of unmixed type were following, stage I 14 cases(45%), stage II 15 cases(48%), and stage III 2 cases(7%), and of mixed type, stage I 1 cases(11%), and stage II was 8 cases(89%). Axillary lymph node metastasis was shown to be negative in 26 cases of unmixed mucinous carcinoma(84%), whereas it did in 544 cases of infilterating ductal carcinoma(48%)(p<0.05). Because all patients with unmixed mucinous carcinoma survived except 2 patients who died of cancer unrelated causes, it was impossible to analyze the difference of outcome in unmixed mucinous carcinoma and infilterating ductal carcinoma(5YSR: 81%).
CONCLUSION
Considering unmixed mucinous carcinoma had fewer axillary lymph node metatasis than infiterating ductal carcinoma, it may be concluded that unmixed mucinous carcinoma had better prognosis.
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Germline Mutations of BRCA1 Gene in Korean Breast and/or Ovarian Cancer Families
Yong Jin Won, Jae Hwan Oh, Xiao Hong Huang, Dong Young Noh, Kuk Jin Choe, Soon Beom Kang, Lee Su Kim, Man Su Noh, Nam Sun Paik, Dae Hyun Yang, Se Min Oh, Soon Nam Lee, Jae Gahb Park
J Korean Cancer Assoc. 1997;29(5):713-723.
AbstractAbstract PDF
PURPOSE
To understand the involvement of BRCA1 gene in Korean breast and/or ovarian cancer families.
MATERIALS AND METHODS
Germline mutations of BRCA1 gene were analyzed in 13 families which included 3 hereditary site-specific breast cancer families, 6 suspected breast cancer families, and 3 suspected breast-ovarian cancer family, and one Li-Fraumeni family by screening BRCA1 gene using single strand conformation polymorphism (SSCP) analysis on polymerase chain reaction (PCR) amplified genomic DNA and confirmed the results by sequencing.
RESULTS
Including one family with previously reported nonsense mutation of BRCA1 gene, we detected two mutations in unrelated families. One newly identified mutation was frame shift mutation resulting from TG deletion in codon 1701, which results in a truncated BRCA1 protein, at codon 1714.
CONCLUSION
The proportion of families who inherit the mutated BRCA1 gene seems to be small among Korean breast and/or ovarian cancer families.
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A Clinicopathologic Analysis of Medullary Breast Cancer
Myung Chul Chang, Jee Soo Kim, Ik Jin Yun, Dong Young Noh, Yeo Kyu Youn, Seung Keun Oh, Kuk Jin Choe, In Ae Park
J Korean Cancer Assoc. 1997;29(3):422-428.
AbstractAbstract PDF
PURPOSE
Medullary carcinoma of breast was known to have a better prognosis than other breast cancer, but the histopathological definition of medullary carcinoma has varied with time. This study was performed to clarify the clinicopathologic features of medullary breast cancer.
MATERIALS AND METHODS
Twenty cases of breast cancer originally were diagnosed as medullary carcinoma at the Department of Surgery, Seoul National University Hospital from Jan. 1985 to Jun. 1995. The whole cases were reviewed and reclassified using the strictly defined histologic criteria applied by Ridolfi et al.
RESULTS
When reclassified, 16 tumors fulfilled the criteria of typical medullary cancer. But the rest 4 tumors were found to be nonmedullary cancer. The patients ranged from 29 to 69 years in age with an average of 49. The main symptom was the painless mass. The diameter of the tumor ranged from 1 to 8 cm with a mean size of 2.7 cm. The axillary lymph node was positive in three cases. The estrogen receptor was positive in 10%, and the progesterone receptor was positive in 20% of the cases. There were no local recurrences or distant metastasis during a mean follow-up period of 5.5 years.. All patients survived until the last follow-up.
CONCLUSION
Medullary breast cancer has good prognosis but strict, uniform histopathological diagnostic criteria are needed.
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Correlation of c-erbB-2 protooncogene amplification with estrogen receptor status in human breast cancer
Hang Jun Cho, Dong Young Noh, Kuk Jin Choe, Ju Bae Park
J Korean Cancer Assoc. 1992;24(6):821-828.
AbstractAbstract PDF
No abstract available.
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Malignant cystosarcoma phyllodes
Dong Young Noh, Soo Jin Kim, Kuk Jin Choe, Jin Pok Kim, Woo Ho Kim
J Korean Cancer Assoc. 1992;24(5):730-736.
AbstractAbstract PDF
No abstract available.
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Recurrent carcinoma of the thyroid
Byung In Moon, Dong Young Noh, Seung Keun Oh
J Korean Cancer Assoc. 1992;24(3):422-427.
AbstractAbstract PDF
No abstract available.
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DNA ploidy, S-phase activity and c-erbB-2 oncogene protein expression in breast cancer and its relationship to prognosis
Dong Young Noh, Kuk Jin Choe, Jin Pok Kim, In Ae Park, Seong Hoe Park, Keun Young Yoo
J Korean Cancer Assoc. 1992;24(1):73-81.
AbstractAbstract PDF
No abstract available.
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Proportionality assuption test of Cox's proportional hazards model in survival analysis
Moo Song Lee, Keun Young Yoo, Dong Young Noh, Kuk Jin Choe
J Korean Cancer Assoc. 1991;23(4):852-859.
AbstractAbstract PDF
No abstract available.
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Comparison of biochemical assay and immunohistochemical assay of estrogen receptor in breast carcinomas
Dong Young Noh, Se Hwan Han, Kuk Jin Choe, Jin Pok Kim, Myung Chul Lee, Seong Hae Park
J Korean Cancer Assoc. 1991;23(4):749-754.
AbstractAbstract PDF
No abstract available.
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A clinical study of breast cancer
Dong Young Noh, Deuk Ho Cha, Jae Won Jo, Young Jin Song, Oh Jung Kwon, In Kyu Hong, Kuk Jin Choe, Jin Pok Kim
J Korean Cancer Assoc. 1991;23(2):410-417.
AbstractAbstract
No abstract available.
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Effect of growth factors and differentiation inducer DMSO on the anaplastic thyroid carcinoma cell line, SNU-80
Seung Keun Oh, Dong Young Noh, Jae Gahb Park
J Korean Cancer Assoc. 1991;23(2):237-246.
AbstractAbstract PDF
No abstract available.
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Establishment of SNU cell lines: november 1989-august 1990
Jae Gahb Park, You Me Jeon, Kyu Ju Park, Han Kwang Yang, Dong Young Noh, Sun Whe Kim, Seung Keun Oh, Kuhn Uk Lee, Yong Hyun Park, Kuk Jin Choe, Jin Pok Kim, Soo Tae Kim
J Korean Cancer Assoc. 1991;23(2):169-187.
AbstractAbstract PDF
No abstract available.
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Correlation of c-erbB-2 protein overexpression in human breast carcinoma with nodal status, tumor size, stage, age and survival
Byung Sik Kim, Dong Young Noh, Kak Jin Choe, Kuhn Kuk Lee, Seong Hoe Park, Yong Il Kim, Joo Bae Park
J Korean Cancer Assoc. 1991;23(1):20-28.
AbstractAbstract PDF
No abstract available.
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Early Gastric Cancer - 137 cases -
Jin Pok Kim, Jae Gahb Park, Dong Young Noh, In Hyuk Oh, Chung Yong Kim, Kyoo Wan Choi, In Sung, Man Chung Han, Yong Il Kim
J Korean Cancer Assoc. 1983;15(1):42-50.
AbstractAbstract PDF
During a thirteen year period from May 1969 to December 1982, 137 cases of early gastric cancer were treated and we could follow 130 cases among them. The incidence of EGC among resected stomach was(9.7%). The male; female ratio was l.8:1 and their average age was 47.2 years. By UGI, double contrast x-ray study, 52.6% of them were diagnosed or suspected as EGC and by gastroscopy 62.6% of them were diagnosed or suspected as EGC. Fifty five cases(42.6%) of them were confined to the mucosa and 74 cases(57.4%) of them were confined to the submucosa. Two cases(3.6%) of mucosal cancer and 20 cases(27%) of submucosal cancer showed lymph node invasion. The most frequent macrotype of EGC was IIc(40%) and microtype was signet ring cell type(39%). The five year survival rate of mucosal cancer was 100% and submucosal cancer was 91% so overall 95%. Since the clinical features do not provide guidelines to diagnosis and there is no ecreening test yet, the diagnosis depends on double contrast barium studies, endoscopy with biopsy and their interpretation. And early detection of the stomach cancer is the most important to improve its pragnosis.
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Establishment of SNU Cell Lines in Growth Factor and Growth hormone Supplemented Medium
Jae Gahb Park, Nam Sook Kwon, Dong Young Noh, In Gyu Hong, Seung Keun Oh, Kuhn Uk Lee, Yong Hyun Park, Sung Kuk Hong, Kuk Jin Choe, Jin Pok Kim, Soo Tae Kim, Dae Seog Heo, Yung Jue Bang, Seon Yang Pa
J Korean Cancer Assoc. 1990;22(1):1-14.
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