Cancer Research and Treatment

Original Article

Adjuvant Postoperative Radiotherapy with or without Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: The Importance of Patient Selection for the Postoperative Chemoradiotherapy: Jong Hoon Lee, Jin Ho Song, Sang Nam Lee, Jin Hyoung Kang, Min Sik Kim, Dong Il Sun, Yeon-Sil Kim; Cancer Res Treat. 2013;45(1):31-39. Published online March 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.1.31

PURPOSE
We wanted to evaluate the role of postoperative chemoradiotherapy (CRT) for patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).
MATERIALS AND METHODS
From March 1993 to July 2008, 101 patients with advanced SCCHN and who had undergone macroscopically complete resection were enrolled. Survival and the cumulative incidence of local or regional relapse, metastasis, and acute toxicity were analyzed.
RESULTS
There was a marginally significant difference of disease-free survival at five years in favor of the CRT arm (51.3% vs. 41.8%, respectively; p=0.10). However, there was no significant difference in overall survival between the two treatment arms (p=0.20). The rate of locoregional failure only for the radiotherapy arm was significantly higher than that for the CRT arm (23.2% vs. 4.4%, respectively; p=0.01). The incidence of grade 3 or 4 hematologic toxicity was significantly higher in the CRT arm than that in the radiotherapy arm (37.7% vs. 1.7%, respectively; p=0.01). In CRT arm, early mortality group within 1 year had low performance status and old age over sixty compared with those of the others.
CONCLUSION
After curative-intent surgery, adjuvant CRT is more effective in locoregional tumor control than radiotherapy alone for patients with advanced SCCHN. However, compared with radiotherapy alone, this combined modality treatment had no survival benefit, and was significantly associated with increased toxicity. Thus, patients with low performance status and old age must be cautious in selection of toxic trimodality treatment.

Citations

Citations to this article as recorded by

Modern management of distant metastases from head and neck squamous cell carcinoma
Patrick Bradley, Claudia Montenegro, Cesare Piazza
Current Opinion in Otolaryngology & Head & Neck Surgery.2025; 33(2): 115. CrossRef
Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study
P. Sharmila Nirojini, N.K. Bhuvaneshwari, N. Dharsshini, S. Dhivya Bharathi, K. Velavan
Indian Journal of Medical and Paediatric Oncology.2024; 45(02): 134. CrossRef
Factors Associated with Patient Survival in Clear Cell Adenocarcinoma of the Cervix: A Single-Center Experience in China
Ting Wang, Zhiying Lu, Xiaodan Zhang, Keqin Hua
International Journal of General Medicine.2022; Volume 15: 4625. CrossRef
Adding Concomitant Chemotherapy to Postoperative Radiotherapy in Oral Cavity Carcinoma with Minor Risk Factors: Systematic Review of the Literature and Meta-Analysis
Alessia Di Rito, Francesco Fiorica, Roberta Carbonara, Francesca Di Pressa, Federica Bertolini, Francesco Mannavola, Frank Lohr, Angela Sardaro, Elisa D’Angelo
Cancers.2022; 14(15): 3704. CrossRef
Metastatic disease in head & neck oncology
Paolo Pisani, Mario Airoldi, Anastasia Allais, Paolo Aluffi Valletti, Mariapina Battista, Marco Benazzo, Roberto Briatore, Salvatore Cacciola, Salvatore Cocuzza, Andrea Colombo, Bice Conti, Alberto Costanzo, Laura della Vecchia, Nerina Denaro, Cesare Fant
Acta Otorhinolaryngologica Italica.2020; 40(SUPPL. 1): S1. CrossRef
The Efficacy of Low Postoperative Radiation Dose in Patients with Advanced Hypopharyngeal Cancer without High-Risk Factors

Hengmin Tao, Zhong Shen, Zhichao Liu, Yumei Wei
Cancer Management and Research.2020; Volume 12: 7553. CrossRef
Contemporary treatment patterns and outcomes of salivary gland carcinoma: a National Cancer Database review
Jay K. Ferrell, Jess C. Mace, Daniel Clayburgh
European Archives of Oto-Rhino-Laryngology.2019; 276(4): 1135. CrossRef
Detection of high PD-L1 expression in oral cancers by a novel monoclonal antibody L1Mab-4
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Yukinari Kato
Biochemistry and Biophysics Reports.2018; 13: 123. CrossRef
Postoperative radiotherapy dose requirement in standard combined-modality practice for head and neck squamous cell carcinoma: Analysis of salient surgical and radiotherapy parameters in 2 cohorts
Bidhu K. Mohanti, Alok Thakar, Jaspreet Kaur, Sudhir Bahadur, Monica Malik, Ajeet K. Gandhi, Suman Bhasker, Atul Sharma
Head & Neck.2017; 39(9): 1788. CrossRef
Silencing of FANCD2 enhances the radiosensitivity of metastatic cervical lymph node-derived head and neck squamous cell carcinoma HSC-4 cells
Hua-Jun Feng, Yi-Lin Bao, Zhuo-Ping Liang, Fei-Peng Zhao, Sheng-En Xu, Wei Xu, Chong Zhao, Gang Qin
International Journal of Oncology.2017; 50(4): 1241. CrossRef
Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?
Merdan Fayda, Mustafa Isin, Makbule Tambas, Murat Guveli, Rasim Meral, Musa Altun, Dilek Sahin, Gozde Ozkan, Yasemin Sanli, Husniye Isin, Emre Ozgur, Ugur Gezer
Tumor Biology.2016; 37(3): 3969. CrossRef
Diagnostic and therapeutic features associated with modification of quality-of-life's outcomes between one and six months after major surgery for head and neck cancer
Margherita Gobbo, Federica Bullo, Giuseppe Perinetti, Annalisa Gatto, Giulia Ottaviani, Matteo Biasotto, Giancarlo Tirelli
Brazilian Journal of Otorhinolaryngology.2016; 82(5): 548. CrossRef
Recurrence patterns after postoperative radiotherapy for squamous cell carcinoma of the pharynx and larynx
Yusuke Iizuka, Michio Yoshimura, Haruo Inokuchi, Yukinori Matsuo, Akira Nakamura, Takashi Mizowaki, Shigeru Hirano, Morimasa Kitamura, Ichiro Tateya, Masahiro Hiraoka
Acta Oto-Laryngologica.2015; 135(1): 96. CrossRef
Chemotherapy of Head and Neck Cancer
Chang Ki Yeo
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2014; 57(5): 291. CrossRef
Photochemotherapeutic effects of UV-C on acridine orange in human breast cancer cells: potential application in anticancer therapy
Arunkumar Pitchaimani, Arun Renganathan, Selvamurugan Cinthaikinian, Kumpati Premkumar
RSC Advances.2014; 4(42): 22123. CrossRef
Analysis of the Prognostic Factors for Distant Metastasis after Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Head and Neck Cancer
Dong Hyun Kim, Won Taek Kim, Joo Hye Lee, Yong Kan Ki, Ji Ho Nam, Byung Joo Lee, Jin Choon Lee, Young Jin Choi, Young Mi Seol, Dong Won Kim
Cancer Research and Treatment.1970; 47(1): 46. CrossRef

25,022 View
84 Download
16 Crossref

First
Prev
Page of 1
Next
Last

Search