Cancer Research and Treatment

Original Articles

Gastrointestinal cancer

Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study: Jeeyoo Lee, Aesun Shin, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee; Cancer Res Treat. 2021;53(1):140-147. Published online August 25, 2020; DOI: https://doi.org/10.4143/crt.2020.480

Purpose
Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries.
Materials and Methods
The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders.
Results
In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45).
Conclusion
Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.

Citations

Citations to this article as recorded by

Implication of calcium supplementations in health and diseases with special focus on colorectal cancer
Shahanavaj Khan, S. Needa Mosvi, Saeed Vohra, Nitesh Kumar Poddar
Critical Reviews in Clinical Laboratory Sciences.2024; 61(6): 496. CrossRef
The burden of colorectal cancer attributable to dietary risk in Middle East and North African from 1990 to 2019
Yahya Pasdar, Fatemeh Khosravi Shadmani, Hawal Lateef Fateh, Davood Soleimani, Behrooz Hamzeh, Mojtaba Ghalandari, Behrooz Moloudpour, Mitra Darbandi
Scientific Reports.2023;[Epub] CrossRef
Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
Epidemiology and Health.2023; 45: e2023102. CrossRef
Anti-colorectal cancer effects of seaweed-derived bioactive compounds
Yunhua Fu, Dong Xie, Yinghao Zhu, Xinyue Zhang, Hao Yue, Kai Zhu, Zifeng Pi, Yulin Dai
Frontiers in Medicine.2022;[Epub] CrossRef
Osteosarcopenic adiposity syndrome update and the role of associated minerals and vitamins
Jasminka Z. Ilich
Proceedings of the Nutrition Society.2021; 80(3): 344. CrossRef

6,429 View
150 Download
5 Crossref

Active and Passive Smoking, BRAF^V600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study: Kyoung-Nam Kim, Yunji Hwang, Kyungsik Kim, Kyu Eun Lee, Young Joo Park, June Young Choi, Do Joon Park, BeLong Cho, Daehee Kang, Sue K. Park; Cancer Res Treat. 2019;51(4):1392-1399. Published online February 20, 2019; DOI: https://doi.org/10.4143/crt.2018.612

Abstract PDF Supplementary Material PubReader ePub

Purpose
The association between tobacco smoking and thyroid cancer remains uncertain. We evaluated the associations of active and passive smokingwith the risk of papillary thyroid cancer (PTC), the most common type of thyroid cancer, and with the BRAFV600E mutation, the most common oncogenic mutation in PTC related to poor prognosis.
Materials and Methods
We conducted this study with newly diagnosed PTC patients (n=2,142) and community controls (n=21,420) individually matched to cases for age and sex. Information on active and passive smoking and potential confounders were obtained from structured questionnaires, anthropometric measurements, and medical records. BRAF^V600E mutation status was assessed in PTC patients. We evaluated the associations of active and passive smoking with PTC and BRAF^V600E mutation risk using conditional and unconditional logistic regression models, respectively.
Results
We did not find associations between exposure indices of active and passive smoking and PTC risk in both men and women, except for the association between current smoking and lower PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.30 to 1.00). The CI for the association was wider in female PTC patients (OR, 0.23; 95% CI, 0.02 to 2.62), possibly owing to a smaller sample size in this stratum.
Conclusion
We did not find consistent associations between active and passive smoking and PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients.

Citations

Citations to this article as recorded by

Geographic variation in the association between Hashimoto’s thyroiditis and Papillary thyroid carcinoma, a meta-analysis
Nabil W. G. Sweis, Ayman A. Zayed, Mira Al Jaberi, Lina AlQirem, Tala Basheer Hyasat, Farah A. Khraisat, Ward Maaita, Ahmad Moayad Naser, Abdullah Nimer, Mamoon Qatamin, Jaleel J. G. Sweis, Nadia Sweis, Abdallah T. Al-Ani, Ahmad M. Alghrabli, Alireza Hagh
Endocrine.2023; 81(3): 432. CrossRef
Sex-specific Associations between Body Mass Index and Thyroid Cancer Incidence among Korean Adults
Kyoung-Nam Kim, Kyungsik Kim, Sangjun Lee, Sue K. Park
Cancer Epidemiology, Biomarkers & Prevention.2023; 32(9): 1227. CrossRef
Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis
Joon-Hyop Lee, Young Jun Chai, Ka Hee Yi
Endocrinology and Metabolism.2021; 36(3): 590. CrossRef
Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes
Sabbir T. Rahman, Nirmala Pandeya, Rachel E. Neale, Donald S. A. McLeod, Peter D. Baade, Philippa H. Youl, Roger Allison, Susan Leonard, Susan J. Jordan
Clinical Endocrinology.2021; 95(6): 891. CrossRef
circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis
Jiazhe Liu, Hongchang Li, Chuanchao Wei, Junbin Ding, Jingfeng Lu, Gaofeng Pan, Anwei Mao, Tao Huang
Computational and Mathematical Methods in Medicine.2020; 2020: 1. CrossRef

6,301 View
187 Download
5 Web of Science
5 Crossref

Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk: Sook Un Kim, Kyoung Mu Lee, Sue Kyung Park, Keun Young Yoo, Dong Young Noh, Kook Jin Choe, Se Hyun Ahn, Daehee Kang; Cancer Res Treat. 2002;34(3):205-211. Published online June 30, 2002; DOI: https://doi.org/10.4143/crt.2002.34.3.205

Abstract PDF

PURPOSE
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
RESULTS
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
CONCLUSION
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.

Citations

Citations to this article as recorded by

Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass
BMC Cancer.2014;[Epub] CrossRef

4,366 View
34 Download
1 Crossref

Dietary Habit and Helicobacter pylori Infection in Early Gastric Cancer Patient: Sang Ah Lee, Daehee Kang, Weon Seon Hong, Ki Nam Shim, Jae Won Choe, Haymie Choi; Cancer Res Treat. 2002;34(2):104-110. Published online April 30, 2002; DOI: https://doi.org/10.4143/crt.2002.34.2.104

Abstract PDF

PURPOSE
Helicobacter pylori (H. pylori) is now generally accepted to be strongly associated with the development of gastric cancer, as well as intakes of some salted foods, charred foods, etc. To evaluate the association among dietary habits, H. pylori infection, and early gastric cancer in Koreans, a hospital based case-control study was conducted. Material and Method: A total of 268 persons participated in this case-control study. Sixty nine patients were newly diagnosed as an early gastric cancer (EGC) at the Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, Seoul, Korea. One hundred ninety-nine subjects with no symptoms who visited the Health Promotion Center for their general checkups were selected as the controls. All subjects were examined for H. pylori infection, biochemical blood test the life style, and dietary habit were interviewed by a trained dietition with semi-quantitative food frequency question naire (FFQ) and adaptive salt concentration were taste evaluated.
RESULTS
H. pylori seropositivity was observed in 88.4% in cases, as compared with 74.9% in controls (OR=2.5, 95% CI: 1.1-5.7). The adaptive salt concentration was associated with early gastric cancer risk (chi-squir=50.8, p<0.001). The analysis of food intake frequency demonstrated that early gastric cancer risk was reduced by the intake of clear soups, raw vegetables, fruits and juices, beef with vegetables and soybean curds. On the other hand, high intake of salt-fermented fish and kimchi elevated the risk of early gastric cancer.
CONCLUSION
These results suggest that some dietary factors and H. pylori infection have a significant association with the development of early gastric cancer.

Citations

Citations to this article as recorded by

Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
Epidemiology and Health.2023; 45: e2023102. CrossRef
Effect of dietary vitamin C on gastric cancer risk in the Korean population
Bach Viet Hoang, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Jeongseon Kim
World Journal of Gastroenterology.2016; 22(27): 6257. CrossRef
Epidemiology and screening of gastric cancer in Korea
Minkyo Song, Hwi-Won Lee, Daehee Kang
Journal of the Korean Medical Association.2015; 58(3): 183. CrossRef
Gastric Cancer Epidemiology in Korea
Aesun Shin, Jeongseon Kim, Sohee Park
Journal of Gastric Cancer.2011; 11(3): 135. CrossRef
Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: A meta‐analysis of observational studies
Hyun Ja Kim, Sun Young Lim, Jung‐Sug Lee, Sohee Park, Aesun Shin, Bo Youl Choi, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Jeongseon Kim
Cancer Science.2010; 101(2): 508. CrossRef
Identifying the Risk Factors Through the Development of a Predictive Model for Gastric Cancer in South Korea
Dong-Suk Lee, Han-Kwang Yang, Jong-Won Kim, Jeong-Whan Yook, Seong-Hoon Jeon, Sung-Hak Kang, Young-Ju Kim
Cancer Nursing.2009; 32(2): 135. CrossRef

5,220 View
60 Download
6 Crossref

Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report): Kyoung Mu Lee, Seung Joon Lee, Sue Kyung Park, Sang Yun Lee, Hyung June Im, Ki Jung Yoon, In Mi Choi, Young Ju Lee, Soo Ung Kim, Hwang Choi, Seung Ho Choi, Young Whan Kim, Soo Han Cho, Daehee Kang; J Korean Cancer Assoc. 2001;33(1):41-48.

Abstract PDF: PURPOSE
The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study.
MATERIALS AND METHODS
Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively.
RESULTS
CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35CONCLUSION
These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.

3,523 View
25 Download

Obesity Related to Breast Cancer Risk by Hormonal Receptor Status: Keun Young Yoo, Sue Kyung Park, Daehee Kang; J Korean Cancer Assoc. 2000;32(5):962-971.

Abstract PDF: PURPOSE
A hospital-based case-control study was designed to assess whether obesity may differ in breast cancer risk according to the estrogen receptor (ER) or progesterone receptor (PR) status.
MATERIALS AND METHODS
Information on life-styles was obtained in a hospital-based cancer registry at the Aichi Cancer Center Hospital, Japan, 1988~1992. Newly diagnosed cases with breast cancer (n=1,154) and controls with no history of cancer (n=21,714) were selected. Body mass index with known and suspected risk factors for breast cancer was included simultaneously in the logistic regression model. Hypothesis tests for differences in odds ratios were done by Wald test based on the polytomous logistic regression models.
RESULTS
Both current weight and body mass index were significantly related to the risk of breast cancer; OR for body weight per 5 kg=1.11 (1.05~1.73), OR for body mass index per 10 kg/m2=1.54 (1.25~1.90). The risks of both body weight and body mass index, however, was not modified by ER, nor by PR.
CONCLUSION
This study strongly suggests that obesity may be associated with breast cancer risk. The possibility that obesity differs according to hormonal receptor status should be pursued in further studies.

2,496 View
19 Download

High Risk Group for Female Breast Cancer in Korea: Keun Young Yoo, Sue Kyung Park, Joohun Sung, Daehee Kang, Young Cheol Kim, Han Sung Kang, Jun Suk Suh, Jee Soo Kim, Ik Jin Yun, Sehwan Han, Dong Young Noh, Kyk Jin Choe; J Korean Cancer Assoc. 1998;30(3):435-449.

Abstract PDF: PURPOSE
A hospital-based case-control study was conducted to find out risk factors for developing breast cancer in Korea.
MATERIALS AND METHODS
Histologically confirmed incident cases of breast cancer(n=280) were selected from inpatients at the Department of General Surgery, Seoul National University Hospital during 1994 to 1997. Women with free of self-reporting past history of any malignancies were regarded as controls who were selected from the inpatients at the Department of Obstetrics and Gynecology of the same hospital during 1992 to 1994(n=930). Information on life-styles including reproductive factors were obtained by direct interview using questionnaire. Age- and education-adjusted odds ratio and 95% confidence interval were estimated by unconditional linear logistic regression.
RESULTS
Based on the risk factors identified by both this study and other epidemiologic studies previously performed in Korea, high risk group for female breast cancer in Korea was established as follows. (1) women with age over 50, (2) women who have a family history of breast cancer, (3) women with age at menarche before 14-year old, (4) women with age at menopause after 50-year old, (5) women who were not experienced a full term pregnancy, (5) nulliparous women (6) women with age at her first fullterm pregnancy after 35-year old (7) women who were not experienced breast feeding, (8) women with body mass index more than 25 kg/m2 or with body weight more than 64 kg.
CONCLUSION
Life-time risk of breast cancer, as an indicator of absolute risk, according to the risk factors should be pursued in further prospective studies with community population.

3,372 View
29 Download

First
Prev
Page of 1
Next
Last

Search