KCA
Search
- Page Path
- HOME > Search
Original Article
- A Modified NHL-BFM-95 Regimen Produces Better Outcome Than HyperCVAD in Adult Patients with T-Lymphoblastic Lymphoma, a Two-Institution Experience
- Chun Li, Zhi-Jun Wuxiao, Xiaoqin Chen, Guanjun Chen, Yue Lu, Zhongjun Xia, Yang Liang, Hua Wang
- Cancer Res Treat. 2020;52(2):573-585. Published online December 6, 2019
- DOI: https://doi.org/10.4143/crt.2019.542
-
Abstract
PDF
Supplementary Material
PubReader
ePub - Purpose
Lymphoblastic lymphoma (LBL) is an invasive neoplasm of precursor T-cell or B-cell lineage. A broadly accepted standard treatment for adult LBL has not yet been defined.
Materials and Methods
To address this issue, we compared two chemotherapy regimens: a modified non-Hodgkin lymphoma Berlin–Frankfurt–Münster-95 (NHL-BFM-95) regimen and HyperCVAD/MA. This retrospective study consecutively enrolled 207 adult LBL patients at two hospitals from 2000 to 2018. Univariate and multivariate analysis were used to assess prognostic factors.
Results
In the present study, most clinical characteristics were similar between the two treatment groups except for age and lactate dehydrogenase (LDH) level. Patients treated with modified NHL-BFM-95 regimen tended to be younger and with elevated LDH level. The modified NHL-BFM- 95 regimen produced better treatment outcomes than those with HyperCVAD/MA in patients with T-LBL or patients < 40 years. Treatment with HyperCVAD/MA, high Eastern Cooperative Oncology Group scores, and bone marrow involvement were independent risk factors in T-LBL. No patients interrupted treatment for severe adverse events.
Conclusion
The results suggested that the modified regimen is well-tolerated and can produce the promising outcomes in patients with T-LBL or patients < 40 years. -
Citations
Citations to this article as recorded by
- Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai
Fangfang Yu, Jiahua Niu, Jianmin Yang, Jian Hou, Siguo Hao, Aibin Liang, Hong Xiong, Qi Zhu, Ligen Liu, Jun Shi, Juan Du, Bobin Chen, Rong Wei, Wenli Zhao, Lihua Sun, Yunhua Hou, Rong Tao, Xianmin Song
Bone Marrow Transplantation.2025; 60(3): 380. CrossRef - Cutaneous Involvement in a Case of T-lymphoblastic Lymphoma: A Rare Presentation
Priyanka Kowe, Madhusmita Sethy, Biswanath Behera, Pritinanda Mishra, Ashutosh Panigrahi
Indian Dermatology Online Journal.2025; 16(2): 326. CrossRef - The Efficacy of Pediatric‐Inspired Regimens vs. Hyper‐CVAD in the Treatment of Adolescents and Young Adults With Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis
Wenqing Su, Melisa Stricherz, Alison Martin, Jonathan Belsey, Eric Kemadjou, Daniel J. DeAngelo
American Journal of Hematology.2025; 100(5): 847. CrossRef - Superiority of allo-SCT to auto-SCT in high-risk T-cell lymphoblastic lymphoma/leukemia patients with aaIPI ≥3: insights from a retrospective, multicenter analysis
Xiaodan Luo, Zhiping Fan, Runhui Zheng, Fen Huang, Na Xu, Pengfei Qin, Jingren Lin, Chunyan Wang, Huiqiang Huang, Huo Tan, Qifa Liu
Blood Science.2025; 7(2): e00222. CrossRef - Subcutaneous panniculitis‐like T‐cell lymphoma in a young girl presenting with periorbital edema and fever: A case report
Seyed Mohamad Kazem Nourbakhsh, Mohammad Bahadoram, Farid Kosari, Mehrdad Jafari, Nahid Aslani, Shakiba Hassanzadeh
Clinical Case Reports.2022;[Epub] CrossRef - Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma
Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai
Blood Science.2022; 4(3): 155. CrossRef - Total Body Irradiation–Based Conditioning Regimen Improved the Survival of Adult Patients With T-Cell Lymphoblastic Lymphoma After Allogeneic Peripheral Blood Stem Cell Transplantation
Jiahua Niu, Zhixiao Chen, Jie Gao, Huiying Qiu, Liping Wan, Ying Wang, Wenwei Wang, Yin Tong, Chongmei Huang, Yu Cai, Xiaowei Xu, Kun Zhou, Ying Zhang, Xinxin Xia, Chang Shen, Yu Wei, Tingfeng Chen, Xianmin Song, Jun Yang
Cell Transplantation.2022;[Epub] CrossRef - Characteristics of growth disturbances in patients with intracranial germinomas of different origins
Bo Li, Jiayi Wang, Jiongxian Yang, Yanong Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu
Child's Nervous System.2021; 37(8): 2531. CrossRef - Event-free survival at 24 months is a robust surrogate endpoint for long-term survival in pediatric, adolescent, and adult T cell lymphoblastic lymphoma
Haizhu Chen, Yan Qin, Jianliang Yang, Peng Liu, Changgong Zhang, Xiaohui He, Shengyu Zhou, Sheng Yang, Lin Gui, Liqiang Zhou, Yan Sun, Yuankai Shi
Annals of Hematology.2020; 99(12): 2847. CrossRef
- Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai
- 8,456 View
- 168 Download
- 8 Web of Science
- 9 Crossref
First
Prev
