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Volume 8(1); 1973
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Original Articles
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TRANSFORMATION OF GUINEA PIG CELLS BY MURINE SARCOMA VIRUS
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Johng S. Rhim
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J Korean Cancer Assoc. 1973;8(1):1-13.
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Abstract
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- Transformation of guinea pig cells by murine sareoma virus (MSV) was studied. Guinea pig(GP) cells were transformed in vitro by the Kirsten strain of MSV (Ki-MSV). The transEormed cells were found to relense infectious virus continuaualy and produced group-specific complement-fixing antigen characteristics of the murine leukemla-sarcoma virus complex. All the focus-derived lines were found to be either producers or nonpro- ducers (NP). The NP guinea pig cells produccd neither virus nor viral antigens. However, the sarcoma virus genome could be rescued in these NP cells by cocultivation with "helper" murine leukemia virus (MuLV) releasing GP cell. Thus, these findings presents evidenee that MSV can transform GP eells in the absence of MuLV, but that MuLV is required for the replieation of infectious MSV particles. Studies on the host range of Ki-MSV indicate that members of the murine sarcoma-leukemia virus complex, particularly Ki-MSV, exhibit a wider host range than was hitherto believed. Particles resembling guinea pig leukemia virus were activated from guinea pig GP cells or eultured normal GP cells following chemieal treatment.
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MALIGNANT SOLID TUMOR OF INFANCY AND CHILDHOOD IN KOREA
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Chae Koo Lee, Sang Kook Lee
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J Korean Cancer Assoc. 1973;8(1):13-19.
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Abstract
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- In several countries cancer is now the second most common causes of death in children over the age of one year. And it has recently become apparent that there is as much variation from country to country and within different communities in childhood as there is in adult cancer. In this connection, a statistical survey- was performed on the primary solid malignant tumors of Korean infants and childhood based on biopay mnter ials. In this study total 700 cases of primary malignant tumors(male 447, female 252 and unknown sex 1) diagnosed during the period of ten years, 1956 to 1967 were colleeted from the major general hospitals thrughout the country. All malignant tumors were classified acearding to the WHO code number. Among solid malignant tumors in both sexes, the .incidence is highest for lymphoma(24. 6%), and thereafter in order of frequency ratios, for retinoblastoma(15.0%), malignant tumors of soft tissue(13. 7%) Wilms' tumor(11. 3%), malignant tumor of gonadal and germ cell (6. 7%), malignant tumor of bone(5. 6%), and neurohlastoma(3.4%), The frequency ratio of malignant tumors among the Korean infants and children show some different points as compared to those of Western European and Amerian populations in that retineblastoma and hepato- cellular earcinoma are more frequent, and among the lymphomas, lympho- sareoma is by far the most frequent type, whereas in the Western countries Hodgkins disease and lymphosareoma oecur about equally.
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LEUKEMIA AMONG KOREANS - A STATICAL AND HEMATOLOGICAL STUDY ON 601 CASES OF LEUKEMIA AND ALLIED CONDITIONS -
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Sang In Kim
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J Korean Cancer Assoc. 1973;8(1):19-25.
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Abstract
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- Six-hundred-one cases af leukemia and allied conditions of Koresns diagnosed by authors at the Seoul National lniversity Hospital during the last 15 years were analysed. The number of leukemia patients are markedly inereased from 51 cases in 1957 1959 to 176 cases in 1969~ 1971, and it wss mainly due to an increase of the acute form leukemia in childhood. The relative frequency of chronic leukemias are rather decrea- sing in recent years. Male to female sex ratio is 1.85: 1 in over-all leukemia cases, however it is 2.26: 1 in the age group of 0-14 years and 1. 40: 1 in the age group of 60 years and over. The sex ratio in ALL, AML and CML is 2.58: 1, 1.63: 1 and 1. 40: 1 respeetively. The age incidence of leukemia is highest at the age group of 0-14 years being 35. 8%(26. 2% in 0-8 year age group), and it decreases gradually with the inerease of age until only 4.0% at the age group of 60 years and over. The type frequencies of leukemia and allied conditions nre AML 88. 1%, ALL 30. 9%, CML 16.0% myelo-monocytic leukemia 5.8%, lymphoma with leukemie manifestation in peripheral blood 3.9%, multiple myeloma 1.7%, erythremic myelosis and erythroleukemia l. 2%, stem cell leukemia 1.0%, and monocytic leukemia 0.8% respectively. The incidence of chronic lymphoid leukemia is very low showing only 0. 5% of the total 601 cases.
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