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Volume 46(1); January 2014
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Editorial
Editorial: New Systems Introduced for the Betterment of Our Journal
Il Han Kim
Cancer Res Treat. 2014;46(1):1-1.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.1
AbstractAbstract PDFPubReaderePub
No abstract available.

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  • Adaptive radiation therapy in head and neck cancer for clinical practice: state of the art and practical challenges
    Ovidiu Veresezan, Idriss Troussier, Alexis Lacout, Sarah Kreps, Sophie Maillard, Aude Toulemonde, Pierre-Yves Marcy, Florence Huguet, Juliette Thariat
    Japanese Journal of Radiology.2017; 35(2): 43.     CrossRef
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Review Article
Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
Sahdeo Prasad, Amit K. Tyagi, Bharat B. Aggarwal
Cancer Res Treat. 2014;46(1):2-18.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.2
AbstractAbstract PDFPubReaderePub

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.

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    Journal of Materials Chemistry B.2016; 4(24): 4295.     CrossRef
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    Mitochondrion.2016; 30: 24.     CrossRef
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    Biochimica et Biophysica Acta (BBA) - General Subjects.2016; 1860(10): 2107.     CrossRef
  • Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells
    Yao Fei, Yajie Xiong, Yifan Zhao, Wenjuan Wang, Meilin Han, Long Wang, Caihong Tan, Zhongqin Liang
    Brain Research.2016; 1646: 580.     CrossRef
  • Curcumin: A new candidate for melanoma therapy?
    Hamed Mirzaei, Gholamreza Naseri, Ramin Rezaee, Mohsen Mohammadi, Zarrin Banikazemi, Hamid Reza Mirzaei, Hossein Salehi, Mostafa Peyvandi, John M. Pawelek, Amirhossein Sahebkar
    International Journal of Cancer.2016; 139(8): 1683.     CrossRef
  • Redox maintenance and concerted modulation of gene expression and signaling pathways by a nanoformulation of curcumin protects peripheral blood mononuclear cells against gamma radiation
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    Chemico-Biological Interactions.2016; 257: 81.     CrossRef
  • PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells
    Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf, Abdelilah Aboussekhra
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    Md Kausar Raza, Koushambi Mitra, Abhijith Shettar, Uttara Basu, Paturu Kondaiah, Akhil R. Chakravarty
    Dalton Transactions.2016; 45(33): 13234.     CrossRef
  • A novel antifungal surface-coating application to limit postharvest decay on coated apples: Molecular, thermal and morphological properties of electrospun zein–nanofiber mats loaded with curcumin
    Azime Yilmaz, Fatih Bozkurt, Perihan Kubra Cicek, Enes Dertli, Muhammed Zeki Durak, Mustafa Tahsin Yilmaz
    Innovative Food Science & Emerging Technologies.2016; 37: 74.     CrossRef
  • Inhibition of Autophagy Enhances Curcumin United light irradiation-induced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells
    Tianhui Niu, Yan Tian, Zhusong Mei, Guangjin Guo
    Scientific Reports.2016;[Epub]     CrossRef
  • Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson’s Disease
    M. D. Pandareesh, M. K. Shrivash, H. N. Naveen Kumar, K. Misra, M. M. Srinivas Bharath
    Neurochemical Research.2016; 41(11): 3113.     CrossRef
  • The Role of Natural Polyphenols in the Prevention and Treatment of Cervical Cancer—An Overview
    Marius Moga, Oana Dimienescu, Cristian Arvatescu, Aurel Mironescu, Laura Dracea, Liana Ples
    Molecules.2016; 21(8): 1055.     CrossRef
  • Spices for Prevention and Treatment of Cancers
    Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
    Nutrients.2016; 8(8): 495.     CrossRef
  • Affinity of nat/68Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers
    Sara Rubagotti, Stefania Croci, Erika Ferrari, Michele Iori, Pier Capponi, Luca Lorenzini, Laura Calzà, Annibale Versari, Mattia Asti
    International Journal of Molecular Sciences.2016; 17(9): 1480.     CrossRef
  • Soluble curcumin amalgamated chitosan microspheres augmented drug delivery and cytotoxicity in colon cancer cells: In vitro and in vivo study
    Kiran Jyoti, Richa Kaur Bhatia, Elvis A.F. Martis, Evans C. Coutinho, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
    Colloids and Surfaces B: Biointerfaces.2016; 148: 674.     CrossRef
  • Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?
    Gabriela Mazzanti, Silvia Di Giacomo
    Molecules.2016; 21(9): 1243.     CrossRef
  • Pluronic stabilized Fe3O4 magnetic nanoparticles for intracellular delivery of curcumin
    K. C. Barick, Ekta Ekta, Santosh L. Gawali, Avipsha Sarkar, A. Kunwar, K. I. Priyadarsini, P. A. Hassan
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  • Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
    Vânia Ortega Gutierres, Michel Leandro Campos, Carlos Alberto Arcaro, Renata Pires Assis, Helen Mariana Baldan-Cimatti, Rosângela Gonçalves Peccinini, Silvia Paula-Gomes, Isis Carmo Kettelhut, Amanda Martins Baviera, Iguatemy Lourenço Brunetti
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  • Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes
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  • Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment
    Heba A. Hazzah, Ragwa M. Farid, Maha M.A. Nasra, Walaa A. Hazzah, Magda A. El-Massik, Ossama Y. Abdallah
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  • Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats
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    Environmental Toxicology and Pharmacology.2015; 40(2): 445.     CrossRef
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  • Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria
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    R. K. Davidson, I. M. Clark
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  • Protective effects of bioconjugates of curcumin with nicotinic and picolinic acids on markers of oxidative stress in human erythrocytes
    Syed Ibrahim Rizvi, Archana Pandey, Ravindra Kumar Gupta, Kanti Bhooshan Pandey
    Biologia.2015; 70(5): 703.     CrossRef
  • The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent
    Koushambi Mitra, Srishti Gautam, Paturu Kondaiah, Akhil R. Chakravarty
    Angewandte Chemie International Edition.2015; 54(47): 13989.     CrossRef
  • The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent
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  • Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling
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  • In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment
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    International Journal of Molecular Sciences.2015; 16(5): 9236.     CrossRef
  • Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice
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  • Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
    Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Yu-Jen Cheng, Jhi-Jhu Hwang, Inn-Wen Chong, Jeremy J.W. Chen
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  • Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
    Tianhui Niu, Yan Tian, Qing Cai, Qu Ren, Lizhao Wei, Andrzej T Slominski
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  • Monoamine oxidase-A inhibitory activity of novel Curcumin analogues
    Vishnu Nayak Badavath, İpek Baysal, Gulberk Ucar, Barij Nayan Sinha, Susanta Kumar Mondal, Venkatesan Jayaprakash
    JOURNAL OF PHARMACEUTICAL CHEMISTRY.2015; 2(3-4): 12.     CrossRef
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    Lixia Wang, Xiantao Ye, Xingming Cai, Jingna Su, Renqiang Ma, Xuyuan Yin, Xiuxia Zhou, Huabin Li, Zhiwei Wang
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  • Novel Evidence for Curcumin and Boswellic Acid–Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer
    Shusuke Toden, Yoshinaga Okugawa, Constanze Buhrmann, Durgha Nattamai, Esperanza Anguiano, Nicole Baldwin, Mehdi Shakibaei, C. Richard Boland, Ajay Goel
    Cancer Prevention Research.2015; 8(5): 431.     CrossRef
  • CHITOSAN ENCAPSULATED CURCUMIN NANOPARTICLES AS AN EFFECTIVE DRUG DELIVERY SYSTEM FOR ORAL CANCER TREATMENT
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  • Novel antitumor mechanisms of curcumin: implication of altered tumor metabolism, reconstituted tumor microenvironment and augmented myelopoiesis
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  • Synthesis, Characterization andIn VitroAnticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation
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    Arshad H. Rahmani, Mohammad A. Al Zohairy, Salah M. Aly, Masood A. Khan
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  • Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells
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  • Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer
    N Hasima, B Ozpolat
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  • Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease Is Phase Specific: Implication of its Therapeutic Effectiveness
    Limamanen Phom, Bovito Achumi, Debasmita P. Alone, Muralidhara, Sarat Chandra Yenisetti
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  • Therapeutic Effects of Curcumin on Alzheimer’s Disease
    Edward C. Yao, Lei Xue
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  • Curcumin and Chronic Kidney Disease (CKD): Major Mode of Action through Stimulating Endogenous Intestinal Alkaline Phosphatase
    Siddhartha Ghosh, Todd Gehr, Shobha Ghosh
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  • Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration
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  • Piperine, a Natural Bioenhancer, Nullifies the Antidiabetic and Antioxidant Activities of Curcumin in Streptozotocin-Diabetic Rats
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  • Synergistic Apoptosis-Inducing Effects on A375 Human Melanoma Cells of Natural Borneol and Curcumin
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  • Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
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  • Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
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Original Articles
A Randomized Double-Blind, Double-Dummy, Multicenter Trial of Azasetron versus Ondansetron to Evaluate Efficacy and Safety in the Prevention of Delayed Nausea and Vomiting Induced by Chemotherapy
Hee Yeon Lee, Hoon-Kyo Kim, Kyung Hee Lee, Bong-Seog Kim, Hong Suk Song, Sung Hyun Yang, Joon Hee Kim, Yeul Hong Kim, Jong Gwang Kim, Sang-We Kim, Dong-Wan Kim, Si-Young Kim, Hee Sook Park
Cancer Res Treat. 2014;46(1):19-26.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.19
AbstractAbstract PDFPubReaderePub
PURPOSE
This study was conducted to evaluate the efficacy and safety of azasetron compared to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting.
MATERIALS AND METHODS
This study was a multi-center, prospective, randomized, double-dummy, double-blind and parallel-group trial involving 12 institutions in Korea between May 2005 and December 2005. A total of 265 patients with moderately and highly emetogenic chemotherapy were included and randomly assigned to either the azasetron or ondansetron group. All patients received azasetron (10 mg intravenously) and dexamethasone (20 mg intravenously) on day 1 and dexamethasone (4 mg orally every 12 hours) on days 2-4. The azasetron group received azasetron (10 mg orally) with placebo of ondansetron (orally every 12 hours), and the ondansetron group received ondansetron (8 mg orally every 12 hours) with placebo of azasetron (orally) on days 2-6.
RESULTS
Over days 2-6, the effective ratio of complete response in the azasetron and ondansetron groups was 45% and 54.5%, respectively (95% confidence interval, -21.4 to 2.5%). Thus, the non-inferiority of azasetron compared with ondansetron in delayed chemotherapy-induced nausea and vomiting was not proven in the present study. All treatments were well tolerated and no unexpected drug-related adverse events were reported. The most common adverse events related to the treatment were constipation and hiccups, and there were no differences in the overall incidence of adverse events.
CONCLUSION
In the present study, azasetron showed inferiority in the control of delayed chemotherapy-induced nausea and vomiting compared with ondansetron whereas safety profiles were similar between the two groups.

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    Ayyar Porkodi, Deepak Gopal Shewade, Goud Alladi Charanraj
    Current Issues in Pharmacy and Medical Sciences.2023; 36(3): 129.     CrossRef
  • Hiccups in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study
    Mevlüde Ergen, Fatma Arikan, Rüya Fırat Çetin
    Journal of Pain and Symptom Management.2021; 62(3): e85.     CrossRef
  • A Fast and Validated HPLC Method for the Simultaneous Analysis of Five 5-HT3 Receptor Antagonists via the Quantitative Analysis of Multicomponents by a Single Marker
    Fuchao Chen, Baoxia Fang, Peng Li, Sicen Wang, Amr M. Mahmoud
    International Journal of Analytical Chemistry.2021; 2021: 1.     CrossRef
  • Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis
    Vanessa Piechotta, Anne Adams, Madhuri Haque, Benjamin Scheckel, Nina Kreuzberger, Ina Monsef, Karin Jordan, Kathrin Kuhr, Nicole Skoetz
    Cochrane Database of Systematic Reviews.2021;[Epub]     CrossRef
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    Hiroki Hosokawa, Hideaki Shimoda, Takayuki Ishii
    YAKUGAKU ZASSHI.2019; 139(4): 647.     CrossRef
  • Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration
    Bao-Xia Fang, Fu-Chao Chen, Dan Zhu, Jun Guo, Lin-Hai Wang
    Oncotarget.2017; 8(63): 106249.     CrossRef
  • Gender Differences in Hiccup Patients: Analysis of Published Case Reports and Case-Control Studies
    Gyeong-Won Lee, Rock Bum Kim, Se Il Go, Hyun Seop Cho, Seung Jun Lee, David Hui, Eduardo Bruera, Jung Hun Kang
    Journal of Pain and Symptom Management.2016; 51(2): 278.     CrossRef
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    Bishal Gyawali, Bishesh Sharma Poudyal, Mahesh Iddawela
    Journal of Global Oncology.2016; 2(3): 145.     CrossRef
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    K. Jordan, F. Jahn, M. Aapro
    Annals of Oncology.2015; 26(6): 1081.     CrossRef
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Chemotherapy in Advanced Gastric Cancer Patients Associated with Disseminated Intravascular Coagulation
In Gyu Hwang, Jin Hwa Choi, Se Hoon Park, Sung Yong Oh, Hyuk-Chan Kwon, Soon Il Lee, Do Hyoung Lim, Gyeong-Won Lee, Jung Hun Kang
Cancer Res Treat. 2014;46(1):27-32.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.27
AbstractAbstract PDFPubReaderePub
PURPOSE
Little is known about the clinical features of advanced gastric cancer (AGC) combined with disseminated intravascular coagulation (DIC). The main objective of this study was to determine the clinical outcome of patients with AGC complicated by DIC.
MATERIALS AND METHODS
We conducted a retrospective review of 68 AGC patients diagnosed with DIC at four tertiary medical centers between January 1995 and June 2010.
RESULTS
Sixty eight patients were included. The median age was 55 years (range, 25 to 78 years). Nineteen patients received chemotherapy, whereas 49 patients received only best supportive care (BSC). The median overall survival (OS) of the 68 patients was 16 days (95% confidence interval [CI], 11 to 21 days). Significantly prolonged OS was observed in the chemotherapy group, with a median survival of 61 days compared to 9 days in the BSC group (p<0.001, log-rank test). Age and previous chemotherapy were another significant factors that were associated with OS in univariate analysis. In multivariate analysis, age (> or =65 vs. <65; hazard ratio [HR], 0.38; 95% CI, 0.18 to 0.78; p<0.001), chemotherapy (BSC vs. chemotherapy; HR 0.31; 95% CI, 0.15 to 0.63; p<0.001), and previous chemotherapy (yes or no; HR, 0.49; 95% CI, 0.25 to 0.98; p<0.045) were consistently independent prognostic factors that impacted OS.
CONCLUSION
Our study showed that patients with AGC complicated by DIC had very poor OS, and suggested that chemotherapy might improve OS of these patients.

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    Hirotaka Suto, Yumiko Inui, Atsuo Okamura
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    Ekaterina Proskuriakova, Vaisny Balamurali, Anuradha Hooda, Paramjeet Khosla
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    Ren-Ze Huang, Nuo Chen, Yan Hu, Wan-Ming Hu, Feng-Hua Wang, Dong-Liang Chen
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Comparative analysis of systemic oncological treatments and best supportive care for advanced gastresophageal cancer: A comprehensive scoping review and evidence map
    Santero Marilina, Meade Adriana, Selva Anna, Acosta‐Dighero Roberto, Meza Nicolás, Quintana Maria Jesús, Bracchiglione Javier, Requeijo Carolina, Salazar Josefina, Rodríguez Grijalva Gerardo, Solà Ivan, Urrútia Gerard, Bonfill Cosp Xavier
    Journal of Evidence-Based Medicine.2023; 16(2): 216.     CrossRef
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    Ling Chen, Jing Lin, Yu Chen, Jiami Yu, Xiaojie Wang
    PeerJ.2023; 11: e16527.     CrossRef
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    Mayu Kobayashi, Hideo Wada, Shunsuke Fukui, Hiroki Mizutani, Yuhuko Ichikawa, Katsuya Shiraki, Isao Moritani, Hidekazu Inoue, Motomu Shimaoka, Hideto Shimpo
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    Sehem Ghazala, Jawad Bilal, Irbaz Bin Riaz
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    Se-Il Go, Min Jeong Lee, Won Sup Lee, Hye Jung Choi, Un Seok Lee, Rock Bum Kim, Myoung Hee Kang, Hoon-Gu Kim, Gyeong-Won Lee, Jung Hun Kang, Jeong-Hee Lee, Sun Joo Kim
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The Role of Radiotherapy in the Treatment of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Taek-Keun Nam, Jae-Sook Ahn, Yoo-Duk Choi, Jae-Uk Jeong, Yong-Hyeob Kim, Mee Sun Yoon, Ju-Young Song, Sung-Ja Ahn, Woong-Ki Chung
Cancer Res Treat. 2014;46(1):33-40.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.33
AbstractAbstract PDFPubReaderePub
PURPOSE
To assess radiotherapy for patients with early stage gastric mucosa-associated lymphoid tissue (MALT) lymphoma with respect to survival, treatment response, and complications.
MATERIALS AND METHODS
Enrolled into this study were 48 patients diagnosed with gastric MALT lymphoma from January 2000 to September 2012. Forty-one patients had low grade and seven had mixed component with high grade. Helicobacter pylori eradication was performed in 33 patients. Thirty-four patients received radiotherapy alone. Ten patients received chemotherapy before radiotherapy, and three patients underwent surgery followed by chemotherapy and radiotherapy. One patient received surgery followed by radiotherapy. All patients received radiotherapy of median dose of 30.6 Gy.
RESULTS
The duration of follow-up ranged from 6 to 158 months (median, 48 months). Five-year overall survival and cause-specific survival rates were 90.3% and 100%. All patients treated with radiotherapy alone achieved pathologic complete remission (pCR) in 31 of the low-grade and in three of the mixed-grade patients. All patients treated with chemotherapy and/or surgery prior to radiotherapy achieved pCR except one patient who received chemotherapy before radiotherapy. During the follow-up period, three patients developed diffuse large B-cell lymphoma in the stomach, and one developed gastric adenocarcinoma after radiotherapy. No grade 3 or higher acute or late complications developed. One patient, who initially exhibited gastroptosis, developed mild atrophy of left kidney.
CONCLUSION
These findings indicate that a modest dose of radiotherapy alone can achieve a high cure rate for low-grade and even mixed-grade gastric MALT lymphoma without serious toxicity. Patients should be carefully observed after radiotherapy to screen for secondary malignancies.

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    Lucy Navsaria, Alfonso Badillo, Michael Wang
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    Aswin Nagarajan, Arun Sakthivelu, Alexander John, Ramya Ravichandar
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    Anne-Laure Rentien, Michaël Lévy, Christiane Copie-Bergman, Charlotte Gagniere, Jehan Dupuis, Yann Le Baleur, Karim Belhadj, Iradj Sobhani, Corinne Haioun, Jean-Charles Delchier, Aurelien Amiot
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    Tamara Matysiak-Budnik, Bettina Fabiani, Christophe Hennequin, Catherine Thieblemont, Georgia Malamut, Guillaume Cadiot, Olivier Bouché, Agnès Ruskoné-Fourmestraux
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    L. Ghorbal, A. Hdiji, H. Ben Salah, F. Elloumi, M. Frikha, M. Elloumi, J. Daoud
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A Distribution Weighted Prognostic Scoring Model for Node Status in Advanced Rectal Cancer
Kwang-Hee Yeo, Ho Hyun Kim, Dong-Yi Kim, Young-Jin Kim, Jae-Kyun Ju
Cancer Res Treat. 2014;46(1):41-47.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.41
AbstractAbstract PDFPubReaderePub
PURPOSE
There are various lymph node-based staging systems. Nevertheless, there is debate over the use of parameters such as the number of involved lymph nodes and the lymph node ratio. As a possible option, the distribution of metastatic lymph nodes may have a prognostic significance in rectal cancer. This study is designed to evaluate the impact of distribution-weighted nodal staging on oncologic outcome in rectal cancer.
MATERIALS AND METHODS
From a prospectively maintained colorectal cancer database of our institution, a total of 435 patients who underwent a curative low anterior resection for mid and upper rectal cancer between 1995 and 2004 were enrolled. Patients were divided into 3 groups according to the location of apical metastatic nodes. A location-weighted prognostic score was calculated by a scoring model using a logistic regression test for location based-statistical weight to number of lymph nodes. All cases were categorized in quartiles from lymph node I to lymph node IV using this protocol.
RESULTS
The location of lymph node metastasis was an independent factor that was associated with a poor prognostic outcome (p<0.001). Based on this result, the location-weighted-nodal prognostic scoring model did not show lesser significant results (p<0.0001) in both overall survival and cancer-free survival analyses.
CONCLUSION
The location of apical nodes among the metastatic nodes does not have a lesser significant impact on oncologic result in patients with advanced rectal cancer. A location-weighted prognostic scoring model, which considered the numbers of involved lymph nodes as the rate of significance according to the location, may more precisely predict the survival outcome in patients with lymph node metastasis.

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    Eyad Fawzi AlSaeed, Mutahir Tunio, Ahmad Zubaidi, Omar Al-Obaid, Abdullah Kamal Ahmed, Omar Abdulmohsen Al-Omar, Emad Ahmed Abid, Mohammed Jaber Alsiwat
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Dose KRAS Mutation Status Affect on the Effect of VEGF Therapy in Metastatic Colon Cancer Patients?
Seung Tae Kim, Kyong Hwa Park, Sang Won Shin, Yeul Hong Kim
Cancer Res Treat. 2014;46(1):48-54.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.48
AbstractAbstract PDFPubReaderePub
PURPOSE
Mutations affecting the KRAS gene are an established negative predictor for anti-epidermal growth factor receptor (anti-EGFR) therapies in metastatic colorectal cancer (CRC). However, the role of KRAS mutation as a biomarker for anti-vascular endothelial growth factor (VEGF) remains controversial.
MATERIALS AND METHODS
We analyzed retrospective data from 32 CRC patients who were available for KRAS mutation status and received cytotoxic chemotherapy plus bevacizumab as a first-line therapy. Six of 32 patients received anti-EGFR therapies. We used KRAS mutation status as a predictive or prognostic factor in CRC patients receiving bevacizumab.
RESULTS
We observed mutations in KRAS in 59.4% of patients. Bevacizumab was used in combination with oxaliplatin based regimens. There was no significant difference for progression free survival (PFS) and overall survival (OS) in patients with oxaliplatin based cytotoxic chemotherapy plus bevacizumab according to the status of KRAS mutation. After first-line therapy, 28 patients (87.5%) received second-line therapy. In univariate analysis, KRAS mutations did not have a major prognostic value for PFS (hazard ratio, 1.007; 95% confidence interval [CI], 0.469 to 2.162; p>0.05) or OS (hazard ratio, 0.548; 95% CI, 0.226 to 1.328; p>0.05). In addition, anti-EGFR therapies did not affect the impact on OS.
CONCLUSION
KRAS mutation is neither a predictive for bevacizumab nor a prognostic for OS in CRC patients receiving anti-VEGF therapy.

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Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil
Jae Joon Han, Sun Kyung Baek, Jae Jin Lee, Gou Young Kim, Si-Young Kim, Suk-Hwan Lee
Cancer Res Treat. 2014;46(1):55-64.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.55
AbstractAbstract PDFPubReaderePub
PURPOSE
The novel heat shock protein tumor necrosis factor receptor-associated protein 1 (TRAP1) is associated with multidrug resistance in colorectal cancer (CRC) cells in vitro. Excision repair cross-complementation group 1 (ERCC1) expression levels in tumor tissues also predict clinical outcomes in metastatic CRC patients receiving combination oxaliplatin and 5-fluorouracil treatment. We investigated whether TRAP1 and ERCC1 protein expression by immunohistochemistry predict clinical outcomes in CRC patients.
MATERIALS AND METHODS
The study population consisted of 56 patients with metastatic CRC who received first-line oxaliplatin/5-fluorouracil therapy. Clinical response and overall survival (OS) by levels of the markers TRAP1 and ERCC1 were evaluated.
RESULTS
The rates of TRAP1 and ERCC1 expression were 21% and 52%, respectively. Patients negative for ERCC1 expression showed a tendency to respond to chemotherapy (p=0.066). Median OS was significantly longer in patients negative for TRAP1 than those positive for TRAP1 (p=0.023). Patients negative for ERCC1 expression also had a better OS than those positive for ERCC1 (p=0.021). The median OS was 30.9 months for patients negative for TRAP1 and ERCC1 compared to 13.2 months for those positive for TRAP1 and/or positive for ERCC1 expression (p=0.006). The combination of TRAP1 and ERCC1 expression was significantly associated with the response to chemotherapy (p=0.046) and independently predicted median OS in multivariate analysis (hazard ratio, 2.98; 95% confidence interval, 1.18 to 7.49).
CONCLUSION
The present study demonstrates that the combination of TRAP1 and ERCC1 expression predicts the survival of metastatic CRC patients who were treated with oxaliplatin/5-fluorouracil.

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    Ying Zhao, Xiaomin Guo, Li Zhang, Dongwei Wang, Yan Li
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Clinical Implications of Systemic Inflammatory Response Markers as Independent Prognostic Factors in Colorectal Cancer Patients
Kwang Yeol Paik, In Kyu Lee, Yoon Suk Lee, Na Young Sung, Taek Soo Kwon
Cancer Res Treat. 2014;46(1):65-73.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.65
AbstractAbstract PDFPubReaderePub
PURPOSE
Cancer-related inflammation affects many aspects of malignancy. We confirm the effects of early postoperative systemic inflammation on cancer prognosis.
MATERIALS AND METHODS
Six hundred consecutive patients underwent surgery for colorectal cancer from 2006 to 2009. Measurements of white blood cells, neutrophils, lymphocytes, monocytes, and platelet counts were performed preoperatively, daily until the fourth postoperative day, and subsequently every two days. Patients were divided into three groups based on the days spent on the leukocyte count to drop below 10,000/mm3 after surgery.
RESULTS
Preoperative white blood cell (WBC) counts correlated with stage of disease. In univariate survival analyses, tumor, node, metastasis (TNM) stage, and monocyte count were associated with cancer-free survival. In addition, cancer-free survival outcomes were worse in patients who required more than four days for the normalization of WBC count. A TNM stage greater than II and the neutrophil lymphocyte ratio were associated with the duration of overall survival. In a multivariate analysis of these significant variables, TNM stage, an interval longer than four days for normalization of WBC counts and monocyte count independently associated with cancer-free survival.
CONCLUSION
Postoperative early inflammatory phase and preoperative monocyte count correlate with poor colon cancer prognosis. We can conclude that preoperative and postoperative inflammatory response and period unfavorably affect the metastatic microenvironment.

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High-Dose-Rate Brachytherapy for the Treatment of Vaginal Intraepithelial Neoplasia
Jin Ho Song, Joo Hwan Lee, Jong Hoon Lee, Jong Sup Park, Sook Hee Hong, Hong Seok Jang, Yeon Sil Kim, Byung Ock Choi, Sei Chul Yoon
Cancer Res Treat. 2014;46(1):74-80.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.74
AbstractAbstract PDFPubReaderePub
PURPOSE
Vaginal intraepithelial neoplasia (VAIN), a rare premalignant condition, is difficult to eradicate. We assess the effectiveness of high-dose rate intracavitary brachytherapy (HDR-ICR) in patients with VAIN or carcinoma in situ (CIS) of the vagina after hysterectomy.
MATERIALS AND METHODS
We reviewed 34 patients treated for posthysterectomy VAIN or CIS of the vagina by brachytherapy as the sole treatment. All patients underwent a coloposcopic-directed punch biopsy or had abnormal cytology, at least 3 consecutive times. All patients were treated with a vaginal cylinder applicator. The total radiation dose was mainly 40 Gy in 8 fractions during the periods of 4 weeks at a prescription point of the median 0.2 cm (range, 0 to 0.5 cm) depth from the surface of the vaginal mucosa.
RESULTS
Acute toxicity was minimal. Seven patients had grade 1/2 acute urinary and rectal complications. There were 15 cases of late toxicity, predominantly vaginal mucosal reaction in 12 patients. Of these patients, two patients suffered from grade 3 vaginal stricture and dyspareunia continuously. After a median follow-up time of 48 months (range, 4 to 122 months), there were 2 recurrences and 2 persistent diseases, in which a second-line therapy was needed. The success rate was 88.2%. The average prescription point in failure patients was 1.1 mm from the surface of the vagina compared to an average of 2.6 mm in non-recurrent patients (p=0.097).
CONCLUSION
HDR-ICR is an effective treatment method in VAIN patients. In spite of high cure rates, we should consider issues regarding vaginal toxicity and radiation techniques to reduce the occurrence of failure and toxicity.

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Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3
Hee Jung Kim, Ga Won Yim, Eun Ji Nam, Young Tae Kim
Cancer Res Treat. 2014;46(1):81-92.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.81
AbstractAbstract PDFPubReaderePub
PURPOSE
Celecoxib, a highly selective cyclooxygenase-2 inhibitor, regulates apoptosis of several types of human cancer cells. The purpose of this study was to investigate whether celecoxib in combination with paclitaxel modulates apoptosis of ovarian cancer cells, and to identify the signal pathway by which celecoxib mediates apoptosis.
MATERIALS AND METHODS
OVCAR-3 cells were exposed to paclitaxel (20 microM) in the absence or presence of celecoxib (10 microM). Cell viability was evaluated using a Cell Counting Kit-8 assay. Apoptosis was evaluated using Annexin-V/7-aminoactinomycin D staining and a cellular DNA fragmentation enzyme-linked immunosorbent assay. Caspase-3, -9, and cleavage of poly ADP-ribose polymerase (PARP) were determined by western blotting. Expression of nuclear factor-kappaB (NF-kappaB) and vascular endothelial growth factor (VEGF) and Akt activation were assessed using reverse transcriptase-polymerase chain reaction and western blotting.
RESULTS
Celecoxib enhanced paclitaxel-induced growth inhibition of OVCAR-3 cells. Celecoxib significantly increased paclitaxel-induced apoptosis of OVCAR-3 cells. Pretreatment with celecoxib also increased activation of caspase-9, -3 and cleaved PARP following paclitaxel-treatment. Exposure of OVCAR-3 cells to celecoxib in combination with paclitaxel resulted in downregulation of NF-kappaB activation and VEGF expression. Furthermore, combining celecoxib and paclitaxel inhibited phosphorylation of Akt.
CONCLUSION
OVCAR-3 cells were sensitized to paclitaxel-induced apoptosis by celecoxib through downregulation of NF-kappaB and Akt activation, suggesting that celecoxib may work synergistically with paclitaxel to inhibit different targets and ultimately produce anticancer effects. Combining celecoxib with paclitaxel may prove beneficial in the clinical treatment of ovarian cancer.

Citations

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    Guohua Jin, Jianguang Zhang, Tingting Cao, He Zhu, Yang Shi, Kapil Sharma
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    Xian Xu, Guo-Qin Zhu, Kai Zhang, Yi-Chan Zhou, Xiao-Lin Li, Wei Xu, Hao Zhang, Yun Shao, Zhen-Yu Zhang, Wei-Hao Sun
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    Hsih-Te Yang, Jiun-Huang Ju, Yue-Ting Wong, Ilya Shmulevich, Jung-Hsien Chiang
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  • Synergistic growth inhibitory effect of deracoxib with doxorubicin against a canine mammary tumor cell line, CMT-U27
    Tülay BAKIREL, Fulya Üstün ALKAN, Oya ÜSTÜNER, Suzan ÇINAR, Funda YILDIRIM, Gaye ERTEN, Utku BAKIREL
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  • Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer
    Andrew J. Wilson, Oluwole Fadare, Alicia Beeghly-Fadiel, Deok-Soo Son, Qi Liu, Shilin Zhao, Jeanette Saskowski, Md. Jashim Uddin, Cristina Daniel, Brenda Crews, Brian D. Lehmann, Jennifer A. Pietenpol, Marta A. Crispens, Lawrence J. Marnett, Dineo Khabele
    Oncotarget.2015; 6(25): 21353.     CrossRef
  • 13,353 View
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Case Reports
Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review
Miso Kim, Dae-Won Lee, Jin Im, Koung Jin Suh, Bhumsuk Keam, Hyeong-Gon Moon, Seock-Ah Im, Wonshik Han, In Ae Park, Dong-Young Noh
Cancer Res Treat. 2014;46(1):93-97.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.93
AbstractAbstract PDFPubReaderePub
Adenoid cystic carcinoma (ACC) of the breast is a very rare and indolent tumor with a favorable prognosis, despite its triple-negative status. Due to its rarity, there has been no consensus regarding treatments, and treatment guidelines have not been established. Here, we report on six patients with ACC of the breast. All of the patients initially presented with localized disease and no axillary lymph node metastases. Although some of our patients developed local recurrence or distant metastases, all patients had a favorable clinical course, and to date, none of the patients has died from complications of her disease. Here, we described the clinicopathologic features of ACC of the breast and review the current literature.

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    Sang Min Lee, Bum-Sup Jang, Won Park, Yong Bae Kim, Jin Ho Song, Jin Hee Kim, Tae Hyun Kim, In Ah Kim, Jong Hoon Lee, Sung-Ja Ahn, Kyubo Kim, Ah Ram Chang, Jeanny Kwon, Hae Jin Park, Kyung Hwan Shin
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    Harsh Batra, Priya S C Bose, Yang Ding, Alan Dai, Hui Chen, Constance T Albarracin, Hongxia Sun, Aysegul A Sahin, Fei Yang, Ignacio I Wistuba, Maria G Raso
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    Joanna Rypel, Paulina Kubacka, Joanna Mykała-Cieśla, Jacek Pająk, Weronika Bulska-Będkowska, Jerzy Chudek
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    Giuseppe Accardo, Alba ML Capobianco, Giuseppe La Torre, Alexios Thodas, Graziella Marino, Leuconoe Grazia Sisti, Giulia Vita
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    Vicente Marco, Felip Garcia, Isabel T. Rubio, Teresa Soler, Laura Ferrazza, Ignasi Roig, Inmaculada Mendez, Xavier Andreu, Clarisa González Mínguez, Francesc Tresserra
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    Wenxiang Zhang, Yi Fang, Zhihui Zhang, Jing Wang
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    Gábor Cserni, Cecily M. Quinn, Maria Pia Foschini, Simonetta Bianchi, Grace Callagy, Ewa Chmielik, Thomas Decker, Falko Fend, Anikó Kovács, Paul J. van Diest, Ian O. Ellis, Emad Rakha, Tibor Tot
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    Thomas Edward Glover, Ryan Butel, Cara Manmeet Bhuller, Emma Louise Senior
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    G. Treglia, F. Bertagna, L. Ceriani, L. Giovanella
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  • Radiologic and Pathological Correlation of Adenoid Cystic Carcinoma of the Breast: A Case Report
    Jung Gyu Kim, Shin Young Kim, Hae Yoen Jung, Sung Yong Kim, Deuk Young Lee, Sang Hyun Park
    Journal of the Korean Society of Radiology.2015; 72(6): 411.     CrossRef
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    Wei Tang, Wei Jun Peng, Ya Jia Gu, Hui Zhu, Ting Ting Jiang, Can Li
    Journal of Computer Assisted Tomography.2015; 39(4): 523.     CrossRef
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    Elizabeth Kander, Sania Raza, Sagar Dhamne, Mariana Solari, Sarika Jain
    Cancer Treatment Communications.2015; 4: 182.     CrossRef
  • Breast Neoplasms with Dermal Analogue Differentiation (Mammary Cylindroma): Report of 3 Cases and a Proposal for a New Terminology
    Emad A. Rakha, Andrew H.S. Lee, Rachael Sheeran, Chris Abbosh, Zsolt Hodi, Will Merchant, Ian O. Ellis, Abeer M. Shaaban
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    Kosuke Miyai
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  • 106 Download
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Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy
Su Lim Lee, Eun Deok Chang, Sae Jung Na, Jeong Soo Kim, Ho Jung An, Yoon Ho Ko, Hye Sung Won
Cancer Res Treat. 2014;46(1):98-103.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.98
AbstractAbstract PDFPubReaderePub
Pseudocirrhosis refers to a condition that shows changes in hepatic contour that mimic cirrhosis radiographically in the absence of the typical histopathological findings of cirrhosis. This condition has been observed in patients with cancer metastatic to the liver, both in those who have undergone prior systemic chemotherapy and those who have not. Pseudocirrhosis may cause difficulty in interpretation of the response to chemotherapy and hepatic decompression and complication of portal hypertension have a negative effect on the prognosis. We report on a case of breast cancer with liver metastases that showed cirrhotic changes during disease progression. Progression of liver metastases was confirmed by F18 fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT). We also performed ultrasound-guided liver biopsy and confirmed tumor infiltration with severe desmoplastic fibrosis. This case suggests the pathogenesis of pseudocirrhosis through histopathological findings and the role of PET-CT in evaluation of the response to chemotherapy in patients with pseudocirrhosis.

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    Laura A. Huppert, Zak Walker, Moming Li, Mi-Ok Kim, Jennifer Callan, Danielle Brandman, Melanie Majure, Michelle E. Melisko, Hope S. Rugo, Spencer Behr, A. Jo Chien
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  • Liposomes, modified with PTDHIV-1 peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer
    Rui-Jun Ju, Xue-Tao Li, Ji-Feng Shi, Xiu-Ying Li, Meng-Ge Sun, Fan Zeng, Jia Zhou, Lei Liu, Cheng-Xiang Zhang, Wei-Yu Zhao, Wan-Liang Lu
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  • 16,559 View
  • 183 Download
  • 26 Web of Science
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Primary Follicular Lymphoma in a Male Breast: A Case Report
Seung Pil Jung, Kang Min Han, Seok Jin Kim, Seok Jin Nam, Jeoung Won Bae, Jeong Eon Lee
Cancer Res Treat. 2014;46(1):104-107.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.104
AbstractAbstract PDFPubReaderePub
Primary breast lymphoma (PBL) is a rare disease, particularly in males. Diffuse large B cell lymphoma is the most common PBL, while follicular lymphoma is less common. Furthermore, primary follicular lymphoma of a male breast is rarely reported. We report a male patient with primary follicular lymphoma of the breast and hepatocellular carcinoma (HCC). A 46-year-old man was diagnosed with liver cirrhosis secondary to chronic hepatitis B infection. Ten years later, he underwent segmentectomy of the liver due to HCC. Another 5 months later, he presented with a painless mass in the right chest wall. The mass was diagnosed as follicular lymphoma of the breast. The stage was IEA and he did not receive adjuvant therapy. Although only a few cases have been reported, lymphoma should be considered as a possible cause of breast mass, even in male patients.

Citations

Citations to this article as recorded by  
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    Fengbo Huang, Yachao Ruan, Xiaojuan He, Hui Lian, Jinhua Yang
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