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Volume 45(3); September 2013
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Review Article
Stereotactic Body Radiotherapy for Early Stage Lung Cancer
Yasushi Nagata
Cancer Res Treat. 2013;45(3):155-161.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.155
AbstractAbstract PDFPubReaderePub
Stereotactic body radiation therapy (SBRT) is a newly developed technique currently in clinical use. SBRT originated from stereotactic radiosurgery for intracranial tumors. SBRT has been widely used clinically for lung cancer. The practice of SBRT demands different kinds of patient fixation, breathing control, target determination, treatment planning, and verifications. The history and current standard technique are reviewed. Clinical studies of lung cancer showed high local control rates with acceptable toxicities. Past and on-going clinical trials are reviewed.

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  • Evaluating the linear accelerator accuracy: Integrating Winston-Lutz measurement method and mathematical calculations
    Hsi-Ya Chao, Wen-Tyng Li, Chih-Chia Chang, Yuk-Wah Tsang
    Radiation Physics and Chemistry.2024; 217: 111504.     CrossRef
  • Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Pain Relief for Bone Metastases: A Systematic Review and Meta-Analysis
    Xing Song, Jun Wei, Rui Sun, Wenjie Jiang, Yuan Chen, Yingjie Shao, Wendong Gu
    International Journal of Radiation Oncology*Biology*Physics.2023; 115(4): 909.     CrossRef
  • Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death
    Chang W. Song, Eli Glatstein, Lawrence B. Marks, Bahman Emami, Jimm Grimm, Paul W. Sperduto, Mi-Sook Kim, Susanta Hui, Kathryn E. Dusenbery, L. Chinsoo Cho
    International Journal of Radiation Oncology*Biology*Physics.2021; 110(1): 21.     CrossRef
  • Improved Survival Outcomes in Medically Fit Patients With Early-Stage Non–Small-Cell Lung Cancer Undergoing Stereotactic Body Radiotherapy
    Jason Liu, Caressa Hui, Colton Ladbury, Thomas Waddington, Loretta Erhunmwunsee, Dan Raz, Jae Kim, Ravi Salgia, Stafford Chenery, Daryl Pearlstein, Amanda Schwer, Arya Amini
    Clinical Lung Cancer.2021; 22(5): e678.     CrossRef
  • Optimization of irradiation interval for fractionated stereotactic radiosurgery by a cellular automata model with reoxygenation effects
    Daisuke Kawahara, Lin Wu, Yoichi Watanabe
    Physics in Medicine & Biology.2020; 65(8): 085008.     CrossRef
  • Effets de l’irradiation à haute dose sur la vascularisation : physiopathologie et conséquences cliniques
    A. Nivet, M. Schlienger, P. Clavère, F. Huguet
    Cancer/Radiothérapie.2019; 23(2): 161.     CrossRef
  • Reoxygenation and Repopulation of Tumor Cells after Ablative Hypofractionated Radiotherapy (SBRT and SRS) in Murine Tumors
    Chang W. Song, Robert J. Griffin, Yoon-Jin Lee, Haeun Cho, Jewoo Seo, Inhwan Park, Hyun K. Kim, Do H. Kim, Mi-Sook Kim, Kathryn E. Dusenbery, L. Chinsoo Cho
    Radiation Research.2019; 192(2): 159.     CrossRef
  • Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo
    Wonwoo Kim, Mi-Sook Kim, Hee-jong Kim, Eunjin Lee, Jae-hoon Jeong, Inhwan Park, Youn Kyoung Jeong, Won Il Jang
    International Journal of Hyperthermia.2018; 34(3): 276.     CrossRef
  • Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues
    Bu-Yeo Kim, Hee Jin, Yoon-Jin Lee, Ga-Young Kang, Jaeho Cho, Yun-Sil Lee
    BMC Genetics.2016;[Epub]     CrossRef
  • Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
    Changhoon Song, Beom-Ju Hong, Seoyeon Bok, Chan-Ju Lee, Young-Eun Kim, Sang-Rok Jeon, Hong-Gyun Wu, Yun-Sang Lee, Gi Jeong Cheon, Jin Chul Paeng, David J. Carlson, Hak Jae Kim, G-One Ahn
    International Journal of Radiation Oncology*Biology*Physics.2016; 95(3): 1022.     CrossRef
  • The impact of emphysema on dosimetric parameters for stereotactic body radiotherapy of the lung
    Satoru Ochiai, Yoshihito Nomoto, Yasufumi Yamashita, Tomoki Inoue, Shuuichi Murashima, Daisuke Hasegawa, Yoshie Kurita, Yui Watanabe, Yutaka Toyomasu, Tomoko Kawamura, Akinori Takada, Noriko Ii, Shigeki Kobayashi, Hajime Sakuma
    Journal of Radiation Research.2016; 57(5): 555.     CrossRef
  • Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery
    Chang W. Song, Yoon-Jin Lee, Robert J. Griffin, Inhwan Park, Nathan A. Koonce, Susanta Hui, Mi-Sook Kim, Kathryn E. Dusenbery, Paul W. Sperduto, L. Chinsoo Cho
    International Journal of Radiation Oncology*Biology*Physics.2015; 93(1): 166.     CrossRef
  • Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor
    Satoru Ochiai, Yoshihito Nomoto, Yasufumi Yamashita, Shuuichi Murashima, Daisuke Hasegawa, Yusuke Kurobe, Yutaka Toyomasu, Tomoko Kawamura, Akinori Takada, Noriko II
    Journal of Radiation Research.2015; 56(6): 904.     CrossRef
  • Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery
    Mi-Sook Kim, Wonwoo Kim, In Hwan Park, Hee Jong Kim, Eunjin Lee, Jae-Hoon Jung, Lawrence Chinsoo Cho, Chang W. Song
    Radiation Oncology Journal.2015; 33(4): 265.     CrossRef
  • Stereotactic Body Radiotherapy Using a Radiobiology-Based Regimen for Stage I Non–Small-Cell Lung Cancer: Five-Year Mature Results
    Yuta Shibamoto, Chisa Hashizume, Fumiya Baba, Shiho Ayakawa, Akifumi Miyakawa, Taro Murai, Taiki Takaoka, Yukiko Hattori, Ryuji Asai
    Journal of Thoracic Oncology.2015; 10(6): 960.     CrossRef
  • Radiobiological basis of SBRT and SRS
    Chang W. Song, Mi-Sook Kim, L. Chinsoo Cho, Kathryn Dusenbery, Paul W. Sperduto
    International Journal of Clinical Oncology.2014; 19(4): 570.     CrossRef
  • Recent advances in radiation oncology
    Yasushi Nagata
    International Journal of Clinical Oncology.2014; 19(4): 563.     CrossRef
  • Current and emerging strategies to increase the efficacy of ionizing radiation in the treatment of cancer
    Anthony J Berdis
    Expert Opinion on Drug Discovery.2014; 9(2): 167.     CrossRef
  • Radiation Oncology: Physics Advances that Minimize Morbidity
    Ron R Allison, Rajen M Patel, Robert A McLawhorn
    Future Oncology.2014; 10(15): 2329.     CrossRef
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Original Articles
Survival of Korean Adult Cancer Patients by Stage at Diagnosis, 2006-2010: National Cancer Registry Study
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Aesun Shin, Jin-Soo Lee
Cancer Res Treat. 2013;45(3):162-171.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.162
AbstractAbstract PDFPubReaderePub
PURPOSE
Although the cancer stage at diagnosis is the most important prognostic factor for patients' survival, there are few population-based estimates of stage-specific survival outcome, especially in Asian countries. Our study aims to estimate stage-specific survival for Korean patients.
MATERIALS AND METHODS
We analyzed the Korea National Cancer Incidence Database data on 626,506 adult patients aged > or = 20 years, who were diagnosed between 2006 and 2010 with stomach, colorectal, liver, lung, breast, cervix, prostate, and thyroid cancers. Patients were followed up to December 2011, and the 5-year relative survival rates (RSRs) were calculated for gender and age group by Surveillance, Epidemiology, and End Results (SEER) stage at diagnosis.
RESULTS
The 5-year RSRs for all localized-stage cancers, except for lung and liver, exceeded 90% with that for thyroid cancer being the highest at 100.4%. These values for distant stage liver, lung, and stomach cancers were very dismal at 2.5%, 4.8%, and 5.5%, respectively, while it was 69.1% for thyroid cancer, and was in the range of 18.3-36.4% for colorectal, cervix, breast and prostate cancers. Overall, the 5-year RSRs for all cancer types decreased with aging across all the disease stages with exception of prostate cancer, which suggests biologic difference in these cancer types in a young age group. When compared with US SEER data, Korean patients had better stage-specific survival rates for stomach, colorectal, liver, and cervical cancers.
CONCLUSION
Korean cancer patients showed relatively favorable stage distribution and 5-year RSRs, which suggests potential contribution of the national cancer screening program.

Citations

Citations to this article as recorded by  
  • Identifying Suitable Patients for Overcoming Androgen Deprivation Monotherapy in De Novo Metastatic Hormone-Sensitive Prostate Cancer
    Donghyun Lee, Bumjin Lim, Tuan Thanh Nguyen, Se Young Choi
    Journal of Personalized Medicine.2024; 14(5): 517.     CrossRef
  • Clinical outcomes of argon plasma coagulation for the treatment of gastric low-grade dysplasia
    Hoyoung Wang, Ji Yong Ahn, Jin Hee Noh, Hee Kyoung Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
    Gastrointestinal Endoscopy.2024; 100(2): 221.     CrossRef
  • Association between Gastric Cancer and Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Sample Cohort
    Kyeong Min Han, Mi Jung Kwon, Joo-Hee Kim, Ji Hee Kim, Woo Jin Bang, Hyo Geun Choi, Dae Myoung Yoo, Na-Eun Lee, Nan Young Kim, Ho Suk Kang
    Cancers.2024; 16(13): 2291.     CrossRef
  • Impact of Disability Status on Mortality in Patients with Gastric Cancer: A Nationwide Study Focusing on Regional Disparities
    Woo-Ri Lee, Kyu-Tae Han, Mingee Choi, Seojin Park, Woorim Kim
    Healthcare.2023; 11(5): 641.     CrossRef
  • Examining Final-Administered Medication as a Measure of Data Quality: A Comparative Analysis of Death Data with the Central Cancer Registry in Republic of Korea
    Yae Won Tak, Jeong Hyun Han, Yu Jin Park, Do-Hoon Kim, Ji Seon Oh, Yura Lee
    Cancers.2023; 15(13): 3371.     CrossRef
  • Physical activity and reduced risk of fracture in thyroid cancer patients after thyroidectomy — a nationwide cohort study
    Jinyoung Kim, Kyungdo Han, Jin-Hyung Jung, Jeonghoon Ha, Chaiho Jeong, Jun-Young Heu, Se-Won Lee, Jeongmin Lee, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The Present and Future of Neoadjuvant and Adjuvant Therapy for Locally Advanced Gastric Cancer
    Anna S. Koerner, Ryan H. Moy, Sandra W. Ryeom, Sam S. Yoon
    Cancers.2023; 15(16): 4114.     CrossRef
  • Trends of stomach cancer survival: A systematic review of survival rates from population‐based cancer registration
    Jia Yi Tuo, Jing Hao Bi, Hui Yun Yuan, Yu Fei Jiang, Xiao Wei Ji, Hong Lan Li, Yong Bing Xiang
    Journal of Digestive Diseases.2022; 23(1): 22.     CrossRef
  • Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study
    Bo Ri Kim, Dong Ho Lee, Hyun Ik Shim, Jee Woo Kim, Sanghyun Park, Cheol Min Shin, Kyungdo Han, Sang Woong Youn
    Annals of Dermatology.2022; 34(3): 191.     CrossRef
  • A novel ferroptosis-related long noncoding RNA signature for relapse free survival prediction in patients with breast cancer
    Yuzhi Wang, Yunfei Xu, Yi Zhang
    Medicine.2022; 101(31): e29573.     CrossRef
  • Patterns of age disparities in colon and lung cancer survival: a systematic narrative literature review
    Sophie Pilleron, Helen Gower, Maryska Janssen-Heijnen, Virginia Claire Signal, Jason K Gurney, Eva JA Morris, Ruth Cunningham, Diana Sarfati
    BMJ Open.2021; 11(3): e044239.     CrossRef
  • Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?
    Chang‐Mo Oh, Jiwon Lim, Yuh Seog Jung, Yeol Kim, Kyu‐Won Jung, Seri Hong, Young‐Joo Won
    Cancer Medicine.2021; 10(12): 4087.     CrossRef
  • Net survival differences of breast cancer between stages at diagnosis and age groups in the east coast region of West Malaysia: a retrospective cohort study
    Tengku Muhammad Hanis, Najib Majdi Yaacob, Suhaily Mohd Hairon, Sarimah Abdullah
    BMJ Open.2021; 11(5): e043642.     CrossRef
  • Improving the Early Diagnosis of Gastric Cancer
    Robert J. Huang, Joo Ha Hwang
    Gastrointestinal Endoscopy Clinics of North America.2021; 31(3): 503.     CrossRef
  • Effect of Pap smear screening on cervical cancer stage at diagnosis: results from the Korean National Cancer Screening Program
    Cam Nhung Bui, Seri Hong, Mina Suh, Jae Kwan Jun, Kyu Won Jung, Myong Cheol Lim, Kui Son Choi
    Journal of Gynecologic Oncology.2021;[Epub]     CrossRef
  • Bacteria-Derived Extracellular Vesicles in Urine as a Novel Biomarker for Gastric Cancer: Integration of Liquid Biopsy and Metagenome Analysis
    Jae-Yong Park, Chil-Sung Kang, Ho-Chan Seo, Jin-Chul Shin, Sung-Min Kym, Young-Soo Park, Tae-Seop Shin, Jae-Gyu Kim, Yoon-Keun Kim
    Cancers.2021; 13(18): 4687.     CrossRef
  • The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis
    Yanlong Shi, Wei Wei, Li Li, Qian Wei, Fei Jiang, Guozhi Xia, Hongzhu Yu
    Bioengineered.2021; 12(2): 12246.     CrossRef
  • Prostate Cancer Screening Using Prostate-Specific Antigen Tests in a High-Risk Population in China: A Cost-Utility Analysis
    Xiaojian Qin, Dingwei Ye, Chengyuan Gu, Yongqiang Huang, Weijie Gu, Bo Dai, Hailiang Zhang, Yao Zhu, Han Yang, Shuli Qu
    Current Therapeutic Research.2021; 95: 100653.     CrossRef
  • CalliSpheres drug-eluting beads transarterial-chemoembolization in the treatment of liver metastases from breast cancer
    Xu Chang, Peng Sun, Jianxin Zhang, Lin Zhang, Huiyong Wu, Yinfa Xie, Jibing Liu
    Medicine.2021; 100(52): e28407.     CrossRef
  • Diagnostic performance of MR imaging in evaluating prognostic factors in patients with cervical cancer: a meta-analysis
    Meiling Xiao, Bicong Yan, Ying Li, Jingjing Lu, Jinwei Qiang
    European Radiology.2020; 30(3): 1405.     CrossRef
  • Burden of male hardcore smokers and its characteristics among those eligible for lung cancer screening
    Dong Won Park, Ji-Yun Jang, Tai Sun Park, Hyun Lee, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Ho Joo Yoon, Dae Ryong Kang, Jang Won Sohn
    BMC Public Health.2020;[Epub]     CrossRef
  • Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4
    Dong Ha Kim, Sojung Park, HyeongRyul Kim, Yun Jung Choi, Seon Ye Kim, Ki Jung Sung, Young Hoon Sung, Chang-Min Choi, Miyong Yun, Young-Su Yi, Chae Won Lee, Sang-Yeob Kim, Jae Cheol Lee, Jin Kyung Rho
    Cancer Letters.2020; 475: 2.     CrossRef
  • A Survey of Liver Cancer Specialists’ Views on the National Liver Cancer Screening Program in Korea
    Won Sohn, Young-Sun Lee, Jae Geun Lee, Jihyun An, Eun Sun Jang, Dong Ho Lee, Dong Hyun Sinn
    Journal of Liver Cancer.2020; 20(1): 53.     CrossRef
  • Chemokine receptor 4 expression is correlated with the occurrence and prognosis of gastric cancer
    Yang Li, Hong‐Chang Wang, Jin‐Shen Wang, Bo Sun, Le‐Ping Li
    FEBS Open Bio.2020; 10(6): 1149.     CrossRef
  • The Management of Gastric Intestinal Metaplasia in the United States: A Controversial Topic
    Robert J. Huang, Joo Ha Hwang
    Gastroenterology.2020; 159(1): 402.     CrossRef
  • PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs
    Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Keun-Wook Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee
    Cancer Research and Treatment.2020; 52(3): 661.     CrossRef
  • Establishment and validation of a novel autophagy-related gene signature for patients with breast cancer
    Jun-Xian Du, Cong Chen, Yi-Hong Luo, Jia-Liang Cai, Cheng-Zhe Cai, Jing Xu, Xiao-Jian Ni, Wei Zhu
    Gene.2020; 762: 144974.     CrossRef
  • The change of bone mineral density and bone metabolism after gastrectomy for gastric cancer: a meta-analysis
    H.J. Oh, B.-H. Yoon, Y.-C. Ha, D.-C. Suh, S.-M. Lee, K.-H. Koo, Y.-K. Lee
    Osteoporosis International.2020; 31(2): 267.     CrossRef
  • Aggressive Local Treatment Improves Survival in Stage IV Breast Cancer With Synchronous Metastasis
    Chen-Lu Lian, Li-Yi Guo, Lei Zhang, Jun Wang, Jian Lei, Li Hua, Zhen-Yu He, San-Gang Wu
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Use of the alkaline phosphatase to prealbumin ratio as an independent predictive factor for the prognosis of gastric cancer
    Yang Li, Jin-Shen Wang, Yun Guo, Tao Zhang, Le-Ping Li
    World Journal of Gastroenterology.2020; 26(44): 6963.     CrossRef
  • One Size Does Not Fit All: Marked Heterogeneity in Incidence of and Survival from Gastric Cancer among Asian American Subgroups
    Robert J. Huang, Nora Sharp, Ruth O. Talamoa, Hanlee P. Ji, Joo Ha Hwang, Latha P. Palaniappan
    Cancer Epidemiology, Biomarkers & Prevention.2020; 29(5): 903.     CrossRef
  • S-1 Based Doublet as an Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer: Results from the Randomized Phase III POST Trial
    Choong-kun Lee, Minkyu Jung, Hyo Song Kim, Inkyung Jung, Dong Bok Shin, Seok Yun Kang, Dae Young Zang, Ki Hyang Kim, Moon Hee Lee, Bong-Seog Kim, Kyung Hee Lee, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyun Cheol Chung, Sun Young Rha
    Cancer Research and Treatment.2019; 51(1): 1.     CrossRef
  • Simple risk assessment in prostate cancer patients treated with primary androgen deprivation therapy: The Korean Cancer Study of the Prostate risk classification
    Se Young Choi, Jeman Ryu, Dalsan You, Jun Hyuk Hong, Hanjong Ahn, Choung‐Soo Kim
    International Journal of Urology.2019; 26(1): 62.     CrossRef
  • A Chance to Cut Is a Chance to Cure: Endoscopic Submucosal Dissection for Early Gastric Cancer
    Robert J. Huang, Gregory W. Charville, Joo Ha Hwang, Shai Friedland
    Digestive Diseases and Sciences.2019; 64(5): 1129.     CrossRef
  • Increased Risk of Osteoporosis in Gastric Cancer Survivors Compared to General Population Control: A Study with Representative Korean Population
    Su-Min Jeong, Dong Wook Shin, Ji Eun Lee, Sang-Man Jin, Sung Kim
    Cancer Research and Treatment.2019; 51(2): 530.     CrossRef
  • Burden of Human papillomavirus (HPV)-related disease and potential impact of HPV vaccines in the Republic of Korea
    Young-Tak Kim, Beatriz Serrano, Jae-Kwan Lee, Hyunju Lee, Shin-Wha Lee, Crystal Freeman, Jin-Kyoung Oh, Laia Alemany, Francesc-Xavier Bosch, Laia Bruni
    Papillomavirus Research.2019; 7: 26.     CrossRef
  • Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial
    Min Hwan Kim, Xianglan Zhang, Minkyu Jung, Inkyung Jung, Hyung Soon Park, Seung-Hoon Beom, Hyo Song Kim, Sun Young Rha, Hyunki Kim, Yoon Young Choi, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyun Cheol Chung
    Cancer Research and Treatment.2019; 51(2): 819.     CrossRef
  • Comparative Effectiveness of Abdominal versus Laparoscopic Radical Hysterectomy for Cervical Cancer in the Postdissemination Era
    Jin Hee Kim, Kyungjoo Kim, Seo Jin Park, Jung-Yun Lee, Kidong Kim, Myong Cheol Lim, Jae Weon Kim
    Cancer Research and Treatment.2019; 51(2): 788.     CrossRef
  • Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients
    Canchang Cheng, Qicai Wang, Minggu Zhu, Kelong Liu, Zhiqiao Zhang
    Cancer Cell International.2019;[Epub]     CrossRef
  • Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD): A study protocol and baseline characteristics
    Chaewon Shin, Han-Kwang Yang, SungHye Park, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Yeon-Ju Huh, Yun-Jeong Kim, So-Yong Park, Tae-Beom Ahn, Seok Hwa Lee, Han-Joon Kim, Beomseok Jeon
    Journal of Clinical Neuroscience.2019; 66: 26.     CrossRef
  • Risk of Dementia in Gastric Cancer Survivors Who Underwent Gastrectomy: A Nationwide Study in Korea
    Yoon Jin Choi, Dong Wook Shin, Wooyoung Jang, Dong Ho Lee, Su-Min Jeong, Sanghyun Park, Kyung-do Han, Yong Gyu Park
    Annals of Surgical Oncology.2019; 26(13): 4229.     CrossRef
  • Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
    Yujun Park, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Cancer Immunology, Immunotherapy.2019; 68(11): 1779.     CrossRef
  • Increased Risk of Osteoporotic Fracture in Postgastrectomy Gastric Cancer Survivors Compared With Matched Controls: A Nationwide Cohort Study in Korea
    Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Yun-Suhk Suh, Yoon Jin Choi, Su-Min Jeong, Jae Moon Yun, Sun Ok Song, Youngmin Park
    American Journal of Gastroenterology.2019; 114(11): 1735.     CrossRef
  • Function of fibroblast growth factor 2 in gastric cancer occurrence and prognosis
    Yang Li, Xiao‑Bo Guo, Jin Wang, Hong‑Chang Wang, Le‑Ping Li
    Molecular Medicine Reports.2019;[Epub]     CrossRef
  • Primary Care Comprehensiveness Can Reduce Emergency Department Visits and Hospitalization in People with Hypertension in South Korea
    Nak-Jin Sung, Yong-Jun Choi, Jae-Ho Lee
    International Journal of Environmental Research and Public Health.2018; 15(2): 272.     CrossRef
  • Liver cirrhosis and cancer: comparison of mortality
    Wankyo Chung, Changik Jo, Woo Jin Chung, Dong Joon Kim
    Hepatology International.2018; 12(3): 269.     CrossRef
  • Reproduction of Gastric Cancer Prognostic Score by real-time quantitative polymerase chain reaction assay in an independent cohort
    Kyoung-Mee Kim, Jeeyun Lee, Se Hoon Park, You Jeong Heo, Ji Ryun Jang, Seungtae Kim, Joon Oh Park, Won Ki Kang, Dakeun Lee, Sang-Uk Han, Ji Young An, Min Gew Choi, Tae Sung Sohn, Jae Moon Bae, Sung Kim
    Precision and Future Medicine.2018; 2(1): 27.     CrossRef
  • Long-term survival of patients with thyroid cancer according to the methods of tumor detection: A nationwide cohort study in Korea
    Yuh-Seog Jung, Chang-Mo Oh, Yeol Kim, Kyu-Won Jung, Junsun Ryu, Young-Joo Won, Pierlorenzo Pallante
    PLOS ONE.2018; 13(4): e0194743.     CrossRef
  • Factors related to cancer screening behaviors
    Boyoung Choi, Tae Rim Um, Kwang-Soo Lee
    Epidemiology and Health.2018; 40: e2018011.     CrossRef
  • Radiological Report of Pilot Study for the Korean Lung Cancer Screening (K-LUCAS) Project: Feasibility of Implementing Lung Imaging Reporting and Data System
    Ji Won Lee, Hyae Young Kim, Jin Mo Goo, Eun Young Kim, Soo Jung Lee, Tae Jung Kim, Yeol Kim, Juntae Lim
    Korean Journal of Radiology.2018; 19(4): 803.     CrossRef
  • The Disease Burden of Lung Cancer Attributable to Residential Radon Exposure in Korean Homes
    Jong-Hun Kim, Mina Ha
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Lifestyle interventions to alleviate side effects on prostate cancer patients receiving androgen deprivation therapy: a meta-analysis
    Miaofa Ying, Rui Zhao, Deqi Jiang, Shenglong Gu, Mingxing Li
    Japanese Journal of Clinical Oncology.2018; 48(9): 827.     CrossRef
  • Dual Energy Spectral CT Imaging in the assessment of Gastric Cancer and cell proliferation: A Preliminary Study
    Sai-Ming Cheng, Wei Ling, Jiong Zhu, Jian-Rong Xu, Lian-Ming Wu, Hong-Xia Gong
    Scientific Reports.2018;[Epub]     CrossRef
  • Therapeutic role of axillary lymph node dissection in patients with stage IV breast cancer: a population-based analysis
    San-Gang Wu, Feng-Yan Li, Yue Chen, Jia-Yuan Sun, Huan-Xin Lin, Qin Lin, Zhen-Yu He
    Journal of Cancer Research and Clinical Oncology.2017; 143(3): 467.     CrossRef
  • Thyroid Cancer Overdiagnosis Is a Result of Screening Programs in South Korea
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    Clinical Thyroidology.2017; 29(1): 8.     CrossRef
  • Fecal occult blood test/fecal carcinoembriogenic antigen dual rapid test as a useful tool for colorectal cancer screening
    Maru Kim, Hyung-Jin Kim, In Kyu Lee, Seong-Taek Oh, Kyungja Han
    European Surgery.2017; 49(3): 127.     CrossRef
  • Supervivencia global de pacientes con cáncer en el Instituto Nacional de Cancerología (INC)
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    Revista Colombiana de Cancerología.2017; 21(1): 12.     CrossRef
  • Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure
    Hyo Jeong Kim, Min Gi Choi, Moo Kyun Park, Young Rok Seo
    Journal of Cancer Prevention.2017; 22(1): 6.     CrossRef
  • The effect of distant metastases sites on survival in de novo stage-IV breast cancer: A SEER database analysis
    San-Gang Wu, Hui Li, Li-Ying Tang, Jia-Yuan Sun, Wen-Wen Zhang, Feng-Yan Li, Yong-Xiong Chen, Zhen-Yu He
    Tumor Biology.2017; 39(6): 101042831770508.     CrossRef
  • Cancer survival in Qidong between 1972 and 2011: A population-based analysis
    Jian-Guo Chen, Jian Zhu, Yong-Hui Zhang, Yi-Xin Zhang, Deng-Fu Yao, Yong-Sheng Chen, Jian-Hua Lu, Lu-Lu Ding, Hai-Zhen Chen, Chao-Yong Zhu, Li-Ping Yang, Yuan-Rong Zhu, Fu-Lin Qiang
    Molecular and Clinical Oncology.2017; 6(6): 944.     CrossRef
  • Influence of Socioeconomic Status, Comorbidity, and Disability on Late-stage Cancer Diagnosis
    Bo Ram Park, So Young Kim, Dong Wook Shin, Hyung Kook Yang, Jong Hyock Park
    Osong Public Health and Research Perspectives.2017; 8(4): 264.     CrossRef
  • Emergency Department Visits Can Be Reduced by Having a Regular Doctor for Adults with Diabetes Mellitus: Secondary Analysis of 2013 Korea Health Panel Data
    Clara Lee, Nak-Jin Sung, Hyeong-Seok Lim, Jae-Ho Lee
    Journal of Korean Medical Science.2017; 32(12): 1921.     CrossRef
  • Conversion to monotherapy with luteinizing-hormone releasing hormone agonist or orchiectomy after reaching PSA nadir following maximal androgen blockade is able to prolong progression-free survival in patients with metastatic prostate cancer: A propensity
    Gyeong Eun Min, Hanjong Ahn
    Oncology Letters.2017; 13(6): 4832.     CrossRef
  • The survival benefits of local surgery in stage IV breast cancer are not affected by breast cancer subtypes: a population-based analysis
    San-Gang Wu, Wen-Weng Zhang, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Juan Zhou, Zhen-Yu He
    Oncotarget.2017; 8(40): 67851.     CrossRef
  • Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer patients
    Jiwon Koh, Chan-Young Ock, Jin Won Kim, Soo Kyung Nam, Yoonjin Kwak, Sumi Yun, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Oncotarget.2017; 8(16): 26356.     CrossRef
  • Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese
    Eunjung Lee, Lihua Liu, Juanjuan Zhang, Mariana C. Stern, Afsaneh Barzi, Amie Hwang, Andre E. Kim, Ann S. Hamilton, Anna H. Wu, Dennis Deapen
    Cancer Epidemiology, Biomarkers & Prevention.2017; 26(4): 587.     CrossRef
  • Financial burden on the families of patients with hepatitis B virus-related liver diseases and the role of public health insurance in Yunnan province of China
    Y.H. Che, V. Chongsuvivatwong, L. Li, H. Sriplung, Y.Y. Wang, J. You, S.J. Ma, Y. Yan, R.Y. Zhang, T. Shen, H.M. Chen, S.F. Rao, X.L. Zhang
    Public Health.2016; 130: 13.     CrossRef
  • Population-based outcomes research on treatment patterns and impact of chemotherapy in older patients with metastatic gastric cancer
    Keun-Wook Lee, Ju Hyun Lee, Jin Won Kim, Ji-Won Kim, Soyeon Ahn, Jee Hyun Kim
    Journal of Cancer Research and Clinical Oncology.2016; 142(3): 687.     CrossRef
  • Cumulative Metformin Use and Its Impact on Survival in Gastric Cancer Patients After Gastrectomy
    Choong-kun Lee, Minkyu Jung, Inkyung Jung, Su Jin Heo, Yong Hyu Jeong, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyo Song Kim, Sun Young Rha, Hyun Cheol Chung
    Annals of Surgery.2016; 263(1): 96.     CrossRef
  • DNA methylation in human papillomavirus-infected cervical cells is elevated in high-grade squamous intraepithelial lesions and cancer
    Mi-Kyung Kim, In-Ho Lee, Ki-Heon Lee, Yoo Kyung Lee, Kyeong A So, Sung Ran Hong, Chang-Sun Hwang, Mee-Kyung Kee, Jee Eun Rhee, Chun Kang, Soo Young Hur, Jong Sup Park, Tae-Jin Kim
    Journal of Gynecologic Oncology.2016;[Epub]     CrossRef
  • Metastatic Thyroid Gland Tumor Presenting as an Initial Manifestation of Recurrent Uterine Cervical Cancer
    So Dam Hong, Jae Kyoung Shin, Hee Jin Hong, Jin Hyung Heo, So Young Chong, Doyoun Oh, Jisu Oh
    The Korean Journal of Medicine.2016; 90(1): 68.     CrossRef
  • Fitness outcomes from a randomised controlled trial of exercise training for men with prostate cancer: the ENGAGE study
    Cadeyrn J. Gaskin, Steve F. Fraser, Patrick J. Owen, Melinda Craike, Liliana Orellana, Patricia M. Livingston
    Journal of Cancer Survivorship.2016; 10(6): 972.     CrossRef
  • Aberrant methylation ofPCDH10andRASSF1Agenes in blood samples for non-invasive diagnosis and prognostic assessment of gastric cancer
    Charinya Pimson, Tipaya Ekalaksananan, Chamsai Pientong, Supannee Promthet, Nuntiput Putthanachote, Krittika Suwanrungruang, Surapon Wiangnon
    PeerJ.2016; 4: e2112.     CrossRef
  • Predictive factors for a long-term response duration in non-squamous cell lung cancer patients treated with pemetrexed
    Sojung Park, Hyun Jung Kim, Chang–Min Choi, Dae Ho Lee, Sang–We Kim, Jung–Shin Lee, Woo Sung Kim, Se Hoon Choi, Jin Kyung Rho, Jae Cheol Lee
    BMC Cancer.2016;[Epub]     CrossRef
  • Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Cancer Research and Treatment.2016; 48(3): 899.     CrossRef
  • Cause of Death in Korean Men with Prostate Cancer: an Analysis of Time Trends in a Nationwide Cohort
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Journal of Korean Medical Science.2016; 31(11): 1802.     CrossRef
  • Does the interval of screening endoscopy affect survival in gastric cancer patients?
    Jieun Kim, Su Mi Kim, Man Ho Ha, Jeong Eun Seo, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Sin-Ho Jung, Jae Moon Bae
    Medicine.2016; 95(49): e5490.     CrossRef
  • Gastric cancer survival and affiliation to health insurance in a middle-income setting
    Esther de Vries, Claudia Uribe, Constanza Pardo, Valery Lemmens, Ellen Van de Poel, David Forman
    Cancer Epidemiology.2015; 39(1): 91.     CrossRef
  • Effect of endoscopy screening on stage at gastric cancer diagnosis: results of the National Cancer Screening Programme in Korea
    K S Choi, J K Jun, M Suh, B Park, D K Noh, S H Song, K W Jung, H-Y Lee, I J Choi, E-C Park
    British Journal of Cancer.2015; 112(3): 608.     CrossRef
  • A phase I/II trial of second-line chemotherapy with paclitaxel and irinotecan in fluoropyrimidine- and platinum-pretreated patients with advanced gastric cancer
    Jin Won Kim, In Sil Choi, Yu Jung Kim, Kyung-Hun Lee, Keun-Wook Lee, Tae-Yong Kim, Sae-Won Han, Jee Hyun Kim, Tae-You Kim, Jong Seok Lee, Yung-Jue Bang, Seock-Ah Im, Do-Youn Oh
    Cancer Chemotherapy and Pharmacology.2015; 75(6): 1175.     CrossRef
  • The Korean guideline for lung cancer screening
    Seung Hun Jang, Seungsoo Sheen, Hyae Young Kim, Hyeon Woo Yim, Bo Young Park, Jae Woo Kim, In Kyu Park, Young Whan Kim, Kye Young Lee, Kyung Soo Lee, Jong Mog Lee, Bin Hwangbo, Sang Hyun Paik, Jin-Hwan Kim, Nak Jin Sung, Sang-hyun Lee, Seung-sik Hwang, So
    Journal of the Korean Medical Association.2015; 58(4): 291.     CrossRef
  • The Korean guideline for gastric cancer screening
    Hyun Ah Park, Su Youn Nam, Sang Kil Lee, Sang Gyun Kim, Ki-Nam Shim, Sang Min Park, Sun-Young Lee, Hye Seung Han, Yong Moon Shin, Kyoung-Mee Kim, Kyung-Jae Lee, Tae-Yong Lee, Il Ju Choi, Seong Sook Hong, Jae Woo Kim, Yoon Jae Lee, Soo Young Kim, Yeol Kim,
    Journal of the Korean Medical Association.2015; 58(5): 373.     CrossRef
  • The Basic Facts of Korean Breast Cancer in 2012: Results from a Nationwide Survey and Breast Cancer Registry Database
    Zisun Kim, Sun Young Min, Chan Seok Yoon, Kyu-Won Jung, Beom Seok Ko, Eunyoung Kang, Seok Jin Nam, Seokwon Lee, Min Hee Hur
    Journal of Breast Cancer.2015; 18(2): 103.     CrossRef
  • Management of gastric cancer: East vs west
    Sook Ryun Park
    Current Problems in Cancer.2015; 39(6): 315.     CrossRef
  • Correlation between Serum 1,25-Dihydroxyvitamin D Levels and Breast Cancer Prognosis in Korea
    Hae Won Bang, Seung Taek Lim, Ye Won Jeon, Young Jin Suh
    Journal of Breast Disease.2015; 3(2): 37.     CrossRef
  • Prognosis of Cervical Cancer in the Era of Concurrent Chemoradiation from National Database in Korea: A Comparison between Squamous Cell Carcinoma and Adenocarcinoma
    Jung-Yun Lee, Young Tae Kim, Sunghoon Kim, Boram Lee, Myong Cheol Lim, Jae-Weon Kim, Young-Joo Won, Jose G. Trevino
    PLOS ONE.2015; 10(12): e0144887.     CrossRef
  • Health Behaviors of Breast Cancer Survivors with Hypertension: A Propensity Analysis of KNHANES III-V (2005-2012)
    Ju-Ri Jeong, Sun Kim, So-Ra Jo, Ju-Youn Joh, Yeon-Pyo Kim, Yinglin Xia
    PLOS ONE.2015; 10(5): e0127346.     CrossRef
  • The Basic Facts of Korean Breast Cancer in 2011: Results of a Nationwide Survey and Breast Cancer Registry Database
    Zisun Kim, Sun Young Min, Chan Seok Yoon, Hun Jae Lee, Jung Sun Lee, Hyun Jo Youn, Heung Kyu Park, Dong-Young Noh, Min Hee Hur
    Journal of Breast Cancer.2014; 17(2): 99.     CrossRef
  • Preoperative MRI criteria for trials on less radical surgery in Stage IB1 cervical cancer
    Jung-Yun Lee, Jina Youm, Tae Hun Kim, Jeong Yeon Cho, Min A Kim, Dong Hoon Suh, Myong Cheol Lim, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
    Gynecologic Oncology.2014; 134(1): 47.     CrossRef
  • A phase II trial of Cremorphor EL-free paclitaxel (Genexol-PM) and gemcitabine in patients with advanced non-small cell lung cancer
    Hee Kyung Ahn, Minkyu Jung, Sun Jin Sym, Dong Bok Shin, Shin Myung Kang, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Eun Kyung Cho
    Cancer Chemotherapy and Pharmacology.2014; 74(2): 277.     CrossRef
  • Lung Cancer Screening
    Young-Woong Won
    Hanyang Medical Reviews.2014; 34(1): 15.     CrossRef
  • Reply on "Characteristics and Survival of Korean Anal Cancer From the Korea Central Cancer Registry Data"
    Hyoung-Chul Park, Bong Hwa Lee
    Annals of Coloproctology.2014; 30(1): 56.     CrossRef
  • A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer
    Y-K Kang, S Y Rha, P Tassone, J Barriuso, R Yu, T Szado, A Garg, Y-J Bang
    British Journal of Cancer.2014; 111(4): 660.     CrossRef
  • Gender-specific Colorectal Cancer: Epidemiologic Difference and Role of Estrogen
    Hee Man Kim, Hyun-Soo Kim
    The Korean Journal of Gastroenterology.2014; 63(4): 201.     CrossRef
  • Cancer Control Programs in East Asia: Evidence From the International Literature
    Malcolm A. Moore
    Journal of Preventive Medicine & Public Health.2014; 47(4): 183.     CrossRef
  • Abiraterone acetate and prednisolone for metastatic castration‐resistant prostate cancer failing androgen deprivation and docetaxel‐based chemotherapy: A phase II bridging study in Korean and Taiwanese patients
    Cheol Kwak, Tony Tong Lin Wu, Hyun Moo Lee, Hsi Chin Wu, Sung Joon Hong, Yen Chuan Ou, Seok Soo Byun, Hyou Young Rhim, Thian Kheoh, Ying Wan, Howard Yeh, Margaret K Yu, Choung Soo Kim
    International Journal of Urology.2014; 21(12): 1239.     CrossRef
  • Stereotactic Body Radiation Therapy for Prostate Cancer Patients with Old Age or Medical Comorbidity
    Sea-Won Lee, Hong Seok Jang, Jong Hoon Lee, Sung Hwan Kim, Sei Chul Yoon
    Medicine.2014; 93(28): e290.     CrossRef
  • Economic Evaluation of Prostate Cancer Screening Test as a National Cancer Screening Program in South Korea
    Sangjin Shin, Youn Hee Kim, Jin Sub Hwang, Yoon Jae Lee, Sang Moo Lee, Jeonghoon Ahn
    Asian Pacific Journal of Cancer Prevention.2014; 15(8): 3383.     CrossRef
  • Reconsideration of Clinical and Histopathological Prognostic Factors in Breast Cancer Patients: A Single Center Experience
    Ozgur Tanriverdi, Nezih Meydan, Sabri Barutca
    Asian Pacific Journal of Cancer Prevention.2014; 15(2): 807.     CrossRef
  • Differences in the Survival of Gastric Cancer Patients after Gastrectomy according to the Medical Insurance Status
    Jae Seong Jang, Dong Gue Shin, Hye Min Cho, Yujin Kwon, Dong Hui Cho, Kyung Bok Lee, Sang Soo Park, Jin Yoon, Yong Seog Jang, Il Myung Kim
    Journal of Gastric Cancer.2013; 13(4): 247.     CrossRef
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A Phase II Study to Evaluate the Efficacy of Ramosetron, Aprepitant, and Dexamethasone in Preventing Cisplatin-Induced Nausea and Vomiting in Chemotherapy-Naive Cancer Patients
Geundoo Jang, Hun Ho Song, Keon Uk Park, Hyeong Su Kim, Dae Ro Choi, Jung Hye Kwon, Ho Young Kim, Boram Han, Jung Han Kim, Joo Young Jung, Hyo Jung Kim, Dae Young Zang
Cancer Res Treat. 2013;45(3):172-177.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.172
AbstractAbstract PDFPubReaderePub
PURPOSE
Combination therapy with aprepitant, serotonin receptor antagonist, and steroids improves the complete response rate of both acute and delayed chemotherapy-induced nausea and vomiting (CINV). However, it is not known whether ramosetron is suitable for administration in combination with aprepitant. Therefore, we conducted a multicenter, open-label, prospective, phase II study in order to assess the efficacy and tolerability of combination therapy with ramosetron, aprepitant, and dexamethasone (RAD) for prevention of cisplatin-based CINV in chemotherapy-naive patients with solid cancers.
MATERIALS AND METHODS
Forty-one patients with various solid cancers (31 male and 10 female; median age, 59 years) who received treatment with highly emetogenic chemotherapy (median cisplatin dose, 70 mg/m2; range 50 to 75 mg/m2) were enrolled in this study. Oral aprepitant (125 mg on day 1; 80 mg on days 2 and 3), intravenous ramosetron (0.6 mg on day 1), and oral dexamethasone (12 mg on day 1; 8 mg on days 2-4) were administered for prevention of CINV.
RESULTS
The complete response (no emesisand retching and no rescue medication) rate was 94.9% in the acute period (24 hours post-chemotherapy), 92.3% in the delayed period (24-120 hours post-chemotherapy), and 92.3% in the overall period (0-120 hours). The absolute complete response (complete response plus no nausea) rate was 74.4% in the acute period, 51.3% in the delayed period, and 46.2% in the overall period. There were no grade 3 or 4 toxicities related to these antiemetic combinations.
CONCLUSION
RAD regimen is a safe and effective antiemetic treatment for prevention of CINV in patients receiving highly emetogenic chemotherapy.

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Citations to this article as recorded by  
  • Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21
    Hyo Jung Kim, Sang Won Shin, Eun-Kee Song, Na-Ri Lee, Jun Suk Kim, Jin Seok Ahn, Hwan-Jung Yun, Yo-Han Cho, Keon Uk Park, Si-Young Kim, Joung Soon Jang, Sang-We Kim, Hyun Woo Lee, Se Ryeon Lee, Yang Soo Kim, Soon Nam Lee, Yoon Ho Ko, Hwa Jung Kim, Jin-Hyo
    The Oncologist.2015; 20(12): 1440.     CrossRef
  • Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration
    Hannah Kenward, Ludovic Pelligand, Jonathan Elliott
    Experimental Brain Research.2014; 232(8): 2685.     CrossRef
  • Anticipatory nausea in animal models: a review of potential novel therapeutic treatments
    Erin M. Rock, Cheryl L. Limebeer, Linda A. Parker
    Experimental Brain Research.2014; 232(8): 2511.     CrossRef
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How Molecular Understanding Affects to Prescribing Patterns and Clinical Outcome of Gefitinib in Non-small Cell Lung Cancer? 10 Year Experience of Single Institution
Bhumsuk Keam, Dong-Wan Kim, Jin Hyun Park, Jeong-Ok Lee, Tae Min Kim, Se-Hoon Lee, Doo Hyun Chung, Dae Seog Heo
Cancer Res Treat. 2013;45(3):178-185.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.178
AbstractAbstract PDFPubReaderePub
PURPOSE
Gefitinib was introduced in 2002 for treatment of non-small cell lung cancer (NSCLC); however, it is not clear whether its use in daily practice has changed the outcome of patients. The purpose of this study is to evaluate the question of how molecular understanding regarding gefitinib and epidermal growth factor receptor (EGFR) mutation affect the prescribing patterns and clinical outcomes of treatment with gefitinib in NSCLC, in a real practical field.
MATERIALS AND METHODS
We conducted a retrospective analysis of the consecutive database of NSCLC patients who were treated with gefitinib at Seoul National University Hospital between January 2002 and December 2011. Prescribing patterns and clinical outcomes were analyzed by year.
RESULTS
A total of 1,115 NSCLC patients, who received gefitinib at recurred or metastatic setting, were included in this study. Proportion of patients receiving gefitinib, for the first line, showed a gradual increase, from 5.2% in 2002-2003 to 30.6% in 2010-2011. Proportion of patients who underwent EGFR mutation testing showed a rapid increase, from 0.6% in 2004-2005 to 73.5% in 2010-2011. The response rate also showed a gradual increase, from 17.2% in 2002-2003 to 57.1% in 2010-2011 (p<0.001). The median progression-free survival of gefitinib was increased with statistical significance from 2.8 months in 2002-2003 to 9.1 months in 2010-2011 (p<0.001).
CONCLUSION
We demonstrated that molecular understanding and practical use of EGFR mutation testing have resulted in a change in the prescription patterns of gefitinib. Use of an enrichment strategy can lead to improvement in the efficacy of gefitinib in real practice.

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  • Utilisation and Determinants of Epidermal Growth Factor Receptor Mutation Testing in Patients with Non-small Cell Lung Cancer in Routine Clinical Practice: A Global Systematic Review
    Aye Myat Thi, Sandar Tin Tin, Mark McKeage, J. Mark Elwood
    Targeted Oncology.2020; 15(3): 279.     CrossRef
  • The Risk of Herpes Zoster in Patients with Non-small Cell Lung Cancer according to Chemotherapy Regimens: Tyrosine Kinase Inhibitors versus Cytotoxic Chemotherapy
    Ji Young Choi, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Seong Jin Jo
    Cancer Research and Treatment.2019; 51(1): 169.     CrossRef
  • EGFR Mutation Testing of non-squamous NSCLC: Impact and Uptake during Implementation of Testing Guidelines in a Population-Based Registry Cohort from Northern New Zealand
    Mark McKeage, Mark Elwood, Sandar Tin Tin, Prashannata Khwaounjoo, Phyu Aye, Angie Li, Karen Sheath, Phillip Shepherd, George Laking, Nicola Kingston, Christopher Lewis, Donald Love
    Targeted Oncology.2017; 12(5): 663.     CrossRef
  • EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and non-adenocarcinoma histology: The IGNITE study
    Baohui Han, Sergei Tjulandin, Koichi Hagiwara, Nicola Normanno, Laksmi Wulandari, Konstantin Laktionov, Achmad Hudoyo, Yong He, Yi-Ping Zhang, Meng-Zhao Wang, Chien Ying Liu, Marianne Ratcliffe, Rose McCormack, Martin Reck
    Lung Cancer.2017; 113: 37.     CrossRef
  • The prognostic value of CT radiomic features for patients with pulmonary adenocarcinoma treated with EGFR tyrosine kinase inhibitors
    Hyungjin Kim, Chang Min Park, Bhumsuk Keam, Sang Joon Park, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Jin Mo Goo, Fan Yang
    PLOS ONE.2017; 12(11): e0187500.     CrossRef
  • Gefitinib-Induced Interstitial Lung Disease in Korean Lung Cancer Patients
    Seung-Hoon Beom, Dong-Wan Kim, Sung Hoon Sim, Bhumsuk Keam, Jin Hyun Park, Jeong-Ok Lee, Tae Min Kim, Se-Hoon Lee, Dae Seog Heo
    Cancer Research and Treatment.2016; 48(1): 88.     CrossRef
  • Evolution of targeted therapies in cancer: opportunities and challenges in the clinic
    Sam Santhosh, Prasanna Kumar, Vedam Ramprasad, Amitabha Chaudhuri
    Future Oncology.2015; 11(2): 279.     CrossRef
  • Total Lesion Glycolysis in Positron Emission Tomography Can Predict Gefitinib Outcomes in Non–Small-Cell Lung Cancer with Activating EGFR Mutation
    Bhumsuk Keam, Soo Jin Lee, Tae Min Kim, Jin Chul Paeng, Se-Hoon Lee, Dong-Wan Kim, Yoon Kyung Jeon, Doo Hyun Chung, Keon Wook Kang, June-Key Chung, Dae Seog Heo
    Journal of Thoracic Oncology.2015; 10(8): 1189.     CrossRef
  • The gefitinib dose reduction on survival outcomes in epidermal growth factor receptor mutant non-small cell lung cancer
    Sung Hoon Sim, Bhumsuk Keam, Dong-Wan Kim, Tae Min Kim, Se-Hoon Lee, Doo Hyun Chung, Dae Seog Heo
    Journal of Cancer Research and Clinical Oncology.2014; 140(12): 2135.     CrossRef
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Prognostic Significance of Serum Carcinoembryonic Antigen Normalization on Survival in Rectal Cancer Treated with Preoperative Chemoradiation
Mi-Joo Chung, Su-Mi Chung, Ji-Yoon Kim, Mi-Ryeong Ryu
Cancer Res Treat. 2013;45(3):186-192.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.186
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this retrospective study was to identify factors predictive of survival in rectal cancer patients who received surgery with curative intent after preoperative chemoradiotherapy (CRT).
MATERIALS AND METHODS
Between July 1996 and June 2010, 104 patients underwent surgery for rectal cancer after preoperative CRT. The median dose of radiotherapy was 50.4 Gy (range, 43.2 to 54.4 Gy) for 6 weeks. Chemotherapy was a bolus injection of 5-fluorouracil and leucovorin for the first and last week of radiotherapy (n=84, 77.1%) or capecitabine administered daily during radiotherapy (n=17, 16.3%). Low anterior resection (n=86, 82.7%) or abdominoperineal resection (n=18, 17.3%) was performed at a median 47 days from the end of radiotherapy, and four cycles of adjuvant chemotherapy was administered. The serum carcinoembryonic antigen (CEA) level was checked at initial diagnosis and just before surgery.
RESULTS
After a median follow-up of 48 months (range, 9 to 174 months), 5-year disease free survival (DFS) was 74.5% and 5-year overall survival (OS) was 86.4%. Down staging of T diagnoses occurred in 32 patients (30.8%) and of N diagnoses in 40 patients (38.5%). The CEA change from initial diagnosis to pre-surgery (high-high vs. high-normal vs. normal-normal) was a statistically significant prognostic factor for DFS (p=0.012), OS (p=0.002), and distant metastasis free survival (p=0.018) in a multivariate analysis.
CONCLUSION
Patients who achieve normal CEA level by the time of surgery have a more favorable outcome than those who retain a high CEA level after preoperative CRT. The normalization of CEA levels can provide important information about the prognosis in rectal cancer treatment.

Citations

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  • Adenocarcinoma of the colon in children with LAL: A case report
    Siham Abbaoui, Najlae Zaari, Abdelouhab Ammor, Houssain Benhaddou
    International Journal of Surgery Case Reports.2024; 121: 109995.     CrossRef
  • Comparison of pathological response of standard chemoradiotherapy versus short course radiotherapy in rectal carcinoma: A pilot study
    Bangalore Rammohan Nagarjun, Ashini Shah, Amisha Gami, Jahnavi Gandhi, Ankita Parikh, Viraj Modi
    Indian Journal of Pathology and Microbiology.2023; 66(4): 708.     CrossRef
  • Can normalized carcinoembryonic antigen following neoadjuvant chemoradiation predict tumour recurrence after curative resection for locally advanced rectal cancer?
    Youngki Hong, Amandeep Ghuman, Keat Seong Poh, Dimitri Krizzuk, Arun Nagarajan, Sudha Amarnath, Juan J. Nogueras, Steven D. Wexner, Giovanna DaSilva
    Colorectal Disease.2021; 23(6): 1346.     CrossRef
  • Prognostic Impact of Carcinoembryonic Antigen Levels in Rectal Cancer Patients Who Had Received Neoadjuvant Chemoradiotherapy
    Jung Il Joo, Sang Woo Lim, Bo Young Oh
    Annals of Coloproctology.2021; 37(3): 179.     CrossRef
  • Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer
    Yu-Han Lin, Chen-Hsuan Wu, Hung-Chun Fu, Yu-Jen Chen, Yin-Yi Chen, Yu-Che Ou, Hao Lin
    Cancer Biomarkers.2020; 28(3): 285.     CrossRef
  • Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy
    Peter Jo, Azadeh Azizian, Junius Salendo, Frank Kramer, Markus Bernhardt, Hendrik Wolff, Jens Gruber, Marian Grade, Tim Beißbarth, B. Ghadimi, Jochen Gaedcke
    International Journal of Molecular Sciences.2017; 18(6): 1140.     CrossRef
  • Two case reports
    Chang hoon Ahn, Soon Chul Kim
    Medicine.2017; 96(46): e8074.     CrossRef
  • Evaluating the Prognostic Role of Elevated Preoperative Carcinoembryonic Antigen Levels in Colon Cancer Patients: Results from the National Cancer Database
    Adan Z. Becerra, Christian P. Probst, Mohamedtaki A. Tejani, Christopher T. Aquina, Maynor G. González, Bradley J. Hensley, Katia Noyes, John R. Monson, Fergal J. Fleming
    Annals of Surgical Oncology.2016; 23(5): 1554.     CrossRef
  • Prognosis Can Be Predicted More Accurately Using Pre- and Postchemoradiotherapy Carcinoembryonic Antigen Levels Compared to Only Prechemoradiotherapy Carcinoembryonic Antigen Level in Locally Advanced Rectal Cancer Patients Who Received Neoadjuvant Chemor
    SooYoon Sung, Seok Hyun Son, Chul Seung Kay, Yoon Suk Lee
    Medicine.2016; 95(10): e2965.     CrossRef
  • Can serum dynamics of carcinoembryonic antigen level during neoadjuvant chemoradiotherapy in rectal cancer predict tumor response and recurrence? A multi-institutional retrospective study
    Mi Joo Chung, Taek Keun Nam, Jae Uk Jeong, Sung Hwan Kim, Kyubo Kim, Hong Seok Jang, Bae Kwon Jeong, Jong Hoon Lee
    International Journal of Colorectal Disease.2016; 31(9): 1595.     CrossRef
  • Postoperative carcinoembryonic antigen level has a prognostic value for distant metastasis and survival in rectal cancer patients who receive preoperative chemoradiotherapy and curative surgery: a retrospective multi-institutional analysis
    Songmi Jeong, Taek Keun Nam, Jae Uk Jeong, Sung Hwan Kim, Kyubo Kim, Hong Seok Jang, Bae Kwon Jeong, Jong Hoon Lee
    Clinical & Experimental Metastasis.2016; 33(8): 809.     CrossRef
  • Biomarkers and Molecular Imaging as Predictors of Response to Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer
    Chiara Molinari, Federica Matteucci, Paola Caroli, Alessandro Passardi
    Clinical Colorectal Cancer.2015; 14(4): 227.     CrossRef
  • Desenlaces del manejo no quirúrgico posterior a neoadyuvancia del cáncer localmente avanzado de recto
    Pilar Adriana Torres-Mesa, Ricardo Oliveros, Jorge Mesa, Natalia Olaya, Ricardo Sánchez
    Revista Colombiana de Cancerología.2014; 18(3): 109.     CrossRef
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  • 68 Download
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Impact of Chemoradiation on Prognosis in Stage IVB Cervical Cancer with Distant Lymphatic Metastasis
Hee Seung Kim, Taehun Kim, Eung Seok Lee, Hak Jae Kim, Hyun Hoon Chung, Jae Weon Kim, Yong Sang Song, Noh Hyun Park
Cancer Res Treat. 2013;45(3):193-201.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.193
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients with stage IVB cervical cancer who have distant lymphatic metastasis.
MATERIALS AND METHODS
Among 2,322 patients with cervical cancer between January 2000 and March 2010, 43 patients (1.9%) had stage IVB disease. After exclusion of 19 patients due to insufficient data and hematogenous metastasis, 24 patients (1%) who received CCR (n=10) or SC (n=14) were enrolled. We compared tumor response, progression-free survival (PFS) and overall survival (OS), and disease recurrence between CCR and SC.
RESULTS
Complete response rates were 60% and 0% after CCR and SC (p<0.01). Grade 3 or 4 leukopenia was more common in patients treated with CCR (24.4% vs. 9.1%, p=0.03), whereas grade 3 or 4 neuropenia was more frequent in those treated with SC (28.4% vs. 11.1%, p=0.03). Development of grade 3 proctitis occurred as a late radiotherapy (RT)-related toxicity in only one patient (10%) treated with CCR. In addition, squamous cell carcinoma and CCR were favorable prognostic factors for improvement of PFS (adjusted hazard ratios [HRs], 0.17 and 0.12; 95% confidence intervals [CIs], 0.04 to 0.80 and 0.03 to 0.61), and only CCR was significant for improvement of OS (adjusted HR, 0.15; 95% CI, 0.02 to 0.90). However, no differences in the rate and pattern of disease recurrence were observed between CCR and SC.
CONCLUSION
CCR may be more effective than SC for improving survival, and can be regarded as a feasible method with some caution regarding late RT-related toxicity for treatment of stage IVB cervical cancer with distant lymphatic metastasis.

Citations

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  • Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy – an Option or a Must?: A Narrative Review
    Sea-Won Lee, Aeran Kim, Sung Jong Lee, Sung Hwan Kim, Jong Hoon Lee
    Cancer Research and Treatment.2024; 56(1): 1.     CrossRef
  • Outcomes associated with treatment to all sites of disease in patients with stage IVB cancer of the cervix
    Shira Peleg Hasson, Shira Felder, Limor Helpman, Alexandra Taylor, Mihal Shalamov, Sireen Abuakar, Smadar Bauer, Ronnie Shapira-Frommer, Inbal Greenhouse, Jacob Korach, Tatiana Rabin, Jeffrey Goldstein, Akram Saad
    International Journal of Gynecologic Cancer.2023; 33(5): 683.     CrossRef
  • Definitive pelvic radiotherapy for patients with newly diagnosed stage IVB cervical cancer: a systematic review
    David Viveros-Carreño, Santiago Vieira-Serna, Carlos Fernando Grillo - Ardila, Juliana Rodriguez, Nathalia Mora-Soto, Anuja Jhingran, Pedro T Ramirez, Rene Pareja
    International Journal of Gynecologic Cancer.2023; 33(7): 1057.     CrossRef
  • Definitive vs palliative pelvic radiation for patients with newly diagnosed stage IVB cervical cancer treated with bevacizumab – An exploratory study
    Rachel L. Wiley, Ioana L. Bondre, Randa Jalloul, Ann H. Klopp, Jolyn S. Taylor, Lois M. Ramondetta
    Gynecologic Oncology Reports.2022; 40: 100963.     CrossRef
  • Survival, treatment pattern, and treatment outcome in patients with cervical cancer metastatic to distant lymph nodes
    Haoliang Lin, Dongyan Wang, Hui Li, Chuling Wu, Fengqian Zhang, Zhongqiu Lin, Tingting Yao
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Dynamic Nomogram Based on the Metastatic Number and Sites and Therapy Strategies Predicting the Prognosis of Patients with Metastatic Cervical Cancer
    Yuan Ma, Jing Li, Xinyue Tan, Mengjiao Cai, Xiaozhi Zhang, Jinlu Ma
    International Journal of Women's Health.2022; Volume 14: 1807.     CrossRef
  • Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
    Satomi Hattori, Nobuhisa Yoshikawa, Kazumasa Mogi, Kosuke Yoshida, Masato Yoshihara, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi, Shiro Suzuki, Hiroaki Kajiyama
    Current Oncology.2021; 28(3): 1663.     CrossRef
  • A Nomogram-Based Risk Classification System Predicting the Overall Survival of Patients With Newly Diagnosed Stage IVB Cervix Uteri Carcinoma
    Wenke Yu, Lu Huang, Zixing Zhong, Tao Song, Hong'en Xu, Yongshi Jia, Jinming Hu, Huafeng Shou
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Surgery of primary sites for stage IVB cervical cancer patients receiving chemoradiotherapy: a population-based study
    Haoran Li, Yangyang Pang, Xi Cheng
    Journal of Gynecologic Oncology.2020;[Epub]     CrossRef
  • Intensity modulated radiation therapy boost in locally-advanced cervical cancer in the absence of brachytherapy
    Roberta Lazzari, Giulia Riva, Matteo Augugliaro, Andrea Vavassori, Samantha Dicuonzo, Federica Cattani, Stefania Comi, Nicoletta Colombo, Barbara Alicja Jereczek-Fossa
    International Journal of Gynecologic Cancer.2020; 30(5): 607.     CrossRef
  • Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer
    Nobuhisa Yoshikawa, Akira Shirakawa, Kosuke Yoshida, Satoshi Tamauchi, Shiro Suzuki, Fumitaka Kikkawa, Hiroaki Kajiyama
    Nutrition in Clinical Practice.2020; 35(6): 1041.     CrossRef
  • Effect of addition of bevacizumab to chemoradiotherapy in newly diagnosed stage IVB cervical cancer: a single institution experience in Korea
    Sang Hee Youn, Yeon-Joo Kim, Sang-Soo Seo, Sokbom Kang, Myong Cheol Lim, Ha Kyun Chang, Sang-Yoon Park, Joo-Young Kim
    International Journal of Gynecologic Cancer.2020; 30(6): 764.     CrossRef
  • Detection of distant metastatic disease by positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) at initial staging of cervical carcinoma
    Alexander Lin, Sirui Ma, Farrokh Dehdashti, Stephanie Markovina, Julie Schwarz, Barry Siegel, Matthew Powell, Perry Grigsby
    International Journal of Gynecologic Cancer.2019; 29(3): 487.     CrossRef
  • Score for the Overall Survival Probability of Patients With First-Diagnosed Distantly Metastatic Cervical Cancer: A Novel Nomogram-Based Risk Assessment System
    Shilong Zhang, Xin Wang, Zhanming Li, Wenrong Wang, Lishun Wang
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Special Focus on Stage IV Cervical Cancer Patients: A Decade Experience
    Sophie Espenel, Max Adrien Garcia, Julien Langrand-Escure, Alexis Vallard, Jane Chloé Trone, Chloé Rancoule, Nicolas Vial, Pablo Moreno-Acosta, Céline Chauleur, Claire Boutet, Michel Peoc'h, Nathalie Prevot-Bitot, Jean Baptiste Guy, Nicolas Magné
    Oncology.2019; 97(3): 125.     CrossRef
  • Selection and identification of novel peptides specifically targeting human cervical cancer
    Xiaomin Liu, Jingwen Peng, Jie He, Qiaoran Li, Jianbin Zhou, Xiaoqiu Liang, Shengsong Tang
    Amino Acids.2018; 50(5): 577.     CrossRef
  • Radiotherapy Improves the Survival of Patients With Metastatic Cervical Cancer: A Propensity-Matched Analysis of SEER Database
    Kejie Huang, Mingfang Jia, Ping Li, Jianglong Han, Rui Zhang, Qin Li, Yunfeng Qiao, TangPeng Xu, Peng Ruan, Qibin Song, Yanbo Li, Zhenming Fu
    International Journal of Gynecologic Cancer.2018; 28(7): 1360.     CrossRef
  • Race and nodal disease status are prognostic factors in patients with stage IVB cervical cancer
    Shin Nishio, Koji Matsuo, Koji Yonemoto, Mototsugu Shimokawa, Masayuki Hosaka, Michiko Kodama, Takahito M. Miyake, Kimio Ushijima, Toshiharu Kamura, Shannon N. Westin, Pamela T. Soliman, Robert L. Coleman
    Oncotarget.2018; 9(64): 32321.     CrossRef
  • Predictors of Survival in Patients With FIGO Stage IVB Cervical Cancer
    Tomoyuki Sasano, Seiji Mabuchi, Hiromasa Kuroda, Ryoko Takahashi, Katsumi Kozasa, Fumiaki Isohashi, Yasuo Yoshioka, Kazuhiko Ogawa, Tadashi Kimura
    International Journal of Gynecological Cancer.2016; 26(3): 528.     CrossRef
  • Advances in diagnosis and treatment of metastatic cervical cancer
    Haoran Li, Xiaohua Wu, Xi Cheng
    Journal of Gynecologic Oncology.2016;[Epub]     CrossRef
  • Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients
    Jung Ho Im, Hong In Yoon, Sunghoon Kim, Eun Ji Nam, Sang Wun Kim, Ga Won Yim, Ki Chang Keum, Young Tae Kim, Gwi Eon Kim, Yong Bae Kim
    Radiation Oncology.2015;[Epub]     CrossRef
  • Cancer of the cervix uteri
    Adriana Bermudez, Neerja Bhatla, Eric Leung
    International Journal of Gynecology & Obstetrics.2015;[Epub]     CrossRef
  • HER2 as a novel therapeutic target for cervical cancer
    Doo-Yi Oh, Seokhwi Kim, Yoon-La Choi, Young Jae Cho, Ensel Oh, Jung-Joo Choi, Kyungsoo Jung, Ji-Young Song, Suzie E. Ahn, Byoung-Gie Kim, Duk-Soo Bae, Woong-Yang Park, Jeong-Won Lee, Sangyong Song
    Oncotarget.2015; 6(34): 36219.     CrossRef
  • Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells
    Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Liu
    Genes & Cancer.2014; 5(5-6): 154.     CrossRef
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Role of Postoperative Radiotherapy for Microscopic Margin Involvement in the Squamous Cell Carcinoma of Esophagus
Sanghyuk Song, Eui Kyu Chie, Hak Jae Kim, Chang-Hyun Kang, Young Tae Kim, Joo Hyun Kim, Charn Il Park
Cancer Res Treat. 2013;45(3):202-209.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.202
AbstractAbstract PDFPubReaderePub
PURPOSE
The objective of this study was to assess the effect of postoperative radiotherapy on the outcome of esophageal cancer with microscopically positive resection margin by comparing the results with those of patients with negative resection margin.
MATERIALS AND METHODS
Medical records of 88 patients treated with macroscopic resection followed by postoperative radiotherapy for stage II or III squamous cell carcinoma of the esophagus from June 1984 to March 2008 were reviewed. Twelve patients had received chemotherapy. Patients were classified into two groups based on resection margin status: negative resection margin (group A, n=66) and microscopically positive resection margin (group B, n=22). Median follow-up duration of living patients was 68 months (range, 18 to 115 months). Median total radiation dose of group A and group B was 51.5 Gy (range, 45 to 69 Gy) and 52.1 Gy (range, 45 to 64 Gy), respectively.
RESULTS
Median overall survival and disease-free survival were 15 and 10 months, respectively. The five-year overall survival, disease-free survival, and local control rates for group A and group B were 15.9% and 16.4%, 13.5% and 9.1%, and 76.3% and 69.6%, respectively. No statistically significant difference in terms of overall survival, disease-free survival, and local control (p=0.295, p=0.209, and p=0.731, respectively) was observed between group A and group B. Seven patients experienced toxicity of grade 3 or higher.
CONCLUSION
A significant portion of patients with margin involvement reached long term survival after addition of postoperative radiotherapy. These results suggest a potential role of postoperative radiotherapy, especially for patients with margin involvement.

Citations

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  • Efficacy of postoperative radiotherapy in esophageal squamous cell carcinoma patients with positive circumferential resection margin
    Reiko Otake, Akihiko Okamura, Kotaro Yamashita, Yu Imamura, Jun Kanamori, Ryotaro Kozuki, Keita Takahashi, Tasuku Toihata, Noriko Yamamoto, Takao Asari, Shinji Mine, Masayuki Watanabe
    Esophagus.2021; 18(2): 288.     CrossRef
  • The Impact of Adjuvant Postoperative Radiation Therapy and Chemotherapy on Survival After Esophagectomy for Esophageal Carcinoma
    Andrew T. Wong, Meng Shao, Justin Rineer, Anna Lee, David Schwartz, David Schreiber
    Annals of Surgery.2017; 265(6): 1146.     CrossRef
  • Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells
    Hyun-Seuk Moon, Saime Batirel, Christos S. Mantzoros
    Metabolism.2014; 63(11): 1447.     CrossRef
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Prognostic Role of Interleukin-6, Interleukin-8, and Leptin Levels According to Breast Cancer Subtype
Young Ae Cho, Mi-Kyung Sung, Jee-Young Yeon, Jungsil Ro, Jeongseon Kim
Cancer Res Treat. 2013;45(3):210-219.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.210
AbstractAbstract PDFPubReaderePub
PURPOSE
Inflammation within the tumor microenvironment has been reported to show an association with poor prognosis in breast cancer. However, the associations may differ according to breast cancer subtype. In this study, we investigated the association between inflammation-related markers and breast cancer recurrence according to patients' tumor subtypes.
MATERIALS AND METHODS
This prospective study included 240 patients who underwent surgery for management of newly diagnosed breast cancer. Levels of inflammation-related markers (interleukin [IL]-1beta, IL-6, IL-8, monocyte chemoattractant protein-1 [MCP-1], leptin, and adiponectin) were measured at diagnosis, and the associations between these markers and breast cancer recurrence during a six-year follow-up period were examined using the Kaplan-Meier statistical method.
RESULTS
Overall, inflammation-related markers showed no association with breast cancer recurrence. However, when data were stratified by tumor subtype, higher levels of some mediators showed an association with poor prognosis among patients with particular subtypes. Compared to patients without recurrence, patients with recurrence had higher levels of circulating IL-6 (p=0.024) and IL-8 (p=0.016) only among those with HER2- tumors and had higher levels of leptin (p=0.034) only among those with estrogen receptor (ER)+/progesterone receptor (PR)+ tumors. Results of survival analyses revealed an association of high levels of IL-6 (p=0.016) and IL-8 (p=0.022) with poor recurrence-free survival in patients with HER2- tumors. In addition, higher leptin levels indicated shorter recurrence-free survival time only among patients with ER+/PR+ tumors (p=0.022).
CONCLUSION
We found that certain cytokines could have a differential prognostic impact on breast cancer recurrence according to breast cancer subtype. Conduct of additional large studies will be required in order to elucidate the precise roles of these cytokines in breast cancer progression.

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  • Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer
    Tim Schauer, Anna Henriksson, Emelie Strandberg, Henrik Lindman, Sveinung Berntsen, Ingrid Demmelmaier, Truls Raastad, Karin Nordin, Jesper F. Christensen
    International Journal of Clinical Oncology.2023; 28(1): 89.     CrossRef
  • Modular microfluidic system for on-chip extraction, preconcentration and detection of the cytokine biomarker IL-6 in biofluid
    Lucile Alexandre, Amel Bendali, Iago Pereiro, Madad Azimani, Simon Dumas, Laurent Malaquin, Thanh Duc Mai, Stéphanie Descroix
    Scientific Reports.2022;[Epub]     CrossRef
  • IL-6: The Link Between Inflammation, Immunity and Breast Cancer
    Juan Chen, Yanghui Wei, Weiqin Yang, Qingnan Huang, Yong Chen, Kai Zeng, Jiawei Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Role of adipose tissue-derived cytokines in the progression of inflammatory breast cancer in patients with obesity
    Aya Saber Ibrahim, Mohamed El-Shinawi, Salwa Sabet, Sherif Abdelaziz Ibrahim, Mona Mostafa Mohamed
    Lipids in Health and Disease.2022;[Epub]     CrossRef
  • Prognostic value of neutrophil-to-lymphocyte ratio for patients with triple-negative breast cancer: A meta-analysis
    Yi Liu, Meilin He, Chuandong Wang, Xiaojuan Zhang, Shaoxin Cai
    Medicine.2022; 101(28): e29887.     CrossRef
  • High Post-Treatment Leptin Concentration as a Prognostic Biomarker of the High Risk of Luminal Breast Cancer Relapse: A Six-Year Comprehensive Study
    Katarzyna Kwiatkowska, Piotr Rhone, Katarzyna Wrzeszcz, Barbara Ruszkowska-Ciastek
    Life.2022; 12(12): 2063.     CrossRef
  • Systemic Inflammatory Response as a Prognostic Factor in Breast Cancer. Part I. Tumor-Promoting Inflammation. Serum Inflammatory Markers
    Natalia S. Sergeeva, Tatiana A. Karmakova, Marianna A. Polyak, Igor I. Alentov, Andrey D. Kaprin
    Annals of the Russian academy of medical sciences.2022; 77(5): 345.     CrossRef
  • Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1
    Divij Mathew, Raul M. Torres
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum
    Muhammad Muhammad, Chang-sheng Shao, Qing Huang
    Sensors and Actuators B: Chemical.2021; 334: 129607.     CrossRef
  • Hypersensitive detection of IL-6 on SERS substrate calibrated by dual model
    Ting Zhou, Dechan Lu, Qiutian She, Cairou Chen, Jingbo Chen, Zufang Huang, Shangyuan Feng, Ruiyun You, Yudong Lu
    Sensors and Actuators B: Chemical.2021; 336: 129597.     CrossRef
  • Obesity-related proteins score as a potential marker of breast cancer risk
    Sha Diao, Xueyao Wu, Xiaofan Zhang, Yu Hao, Bin Xu, Xu Li, Lulu Tian, Yunqi Miao, Xunying Zhao, Feng Ye, Jiayuan Li
    Scientific Reports.2021;[Epub]     CrossRef
  • Preoperative Fibrinogen and Hematological Indexes in the Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer
    Mehmet Velidedeoglu, Berrin Papila Kundaktepe, Hulya Aksan, Hafize Uzun
    Medicina.2021; 57(7): 698.     CrossRef
  • Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells
    Sarra Bouaouiche, Silvia Ghione, Randa Sghaier, Olivier Burgy, Cindy Racoeur, Valentin Derangère, Ali Bettaieb, Stéphanie Plenchette
    International Journal of Molecular Sciences.2021; 22(16): 8449.     CrossRef
  • Association of circulating leptin, adiponectin, and resistin concentrations with long-term breast cancer prognosis in a German patient cohort
    Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude
    Scientific Reports.2021;[Epub]     CrossRef
  • Radiation induces an inflammatory response that results in STAT3-dependent changes in cellular plasticity and radioresistance of breast cancer stem-like cells
    Kimberly M. Arnold, Lynn M. Opdenaker, Nicole J. Flynn, Daniel Kwesi Appeah, Jennifer Sims-Mourtada
    International Journal of Radiation Biology.2020; 96(4): 434.     CrossRef
  • The −174G>C and −596G>A Polymorphisms Are Not Associated with Circulating IL-6 Levels in Breast Cancer Patients from Jalisco, México
    David Javalera, Antonio Quintero-Ramos, Yadira Medina-Mora, Alicia Del Toro-Arreola, Ramon Antonio Franco-Topete, Antonio Oceguera-Villanueva, Adelfo Barragán-Ruiz, Maria Rosa Flores-Márquez, Antonio Topete, Adrian Daneri-Navarro
    Genetic Testing and Molecular Biomarkers.2020; 24(4): 224.     CrossRef
  • Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas
    Noemi Eiro, Sandra Cid, María Fraile, Jorge Ruben Cabrera, Luis O. Gonzalez, Francisco J. Vizoso
    Diagnostics.2020; 10(11): 865.     CrossRef
  • Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8
    Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee, Chanitra Thuwajit
    BMC Cancer.2018;[Epub]     CrossRef
  • Association of Metabolic, Inflammatory, and Tumor Markers With Circulating Tumor Cells in Metastatic Breast Cancer
    Ana Elisa Lohmann, Ryan J O Dowling, Marguerite Ennis, Eitan Amir, Christine Elser, Christine Brezden-Masley, Theodore Vandenberg, Elma Lee, Kamran Fazaee, Vuk Stambolic, Pamela J Goodwin, Martin C Chang
    JNCI Cancer Spectrum.2018;[Epub]     CrossRef
  • Serum adiponectin in breast cancer
    Li Gu, Chang Cao, Jing Fu, Qian Li, De-Hua Li, Ming-Yao Chen
    Medicine.2018; 97(29): e11433.     CrossRef
  • Impact of serum vascular endothelial growth factor and interleukin-6 on treatment response to epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small-cell lung cancer
    Yijun Jia, Xuefei Li, Chao Zhao, Tao Jiang, Sha Zhao, Limin Zhang, Xiaozhen Liu, Jinpeng Shi, Meng Qiao, Jiawei Luo, Sangtian Liu, Ruoshuang Han, Xiaoxia Chen, Caicun Zhou
    Lung Cancer.2018; 125: 22.     CrossRef
  • Laser direct-write based fabrication of a spatially-defined, biomimetic construct as a potential model for breast cancer cell invasion into adipose tissue
    Benjamin T Vinson, Theresa B Phamduy, Joshua Shipman, Brian Riggs, Amy L Strong, Samuel C Sklare, Walter L Murfee, Matthew E Burow, Bruce A Bunnell, Yong Huang, Douglas B Chrisey
    Biofabrication.2017; 9(2): 025013.     CrossRef
  • Circulating leptin and adiponectin, and breast density in premenopausal Mexican women: the Mexican Teachers’ Cohort
    L. Dossus, S. Rinaldi, C. Biessy, M. Hernandez, M. Lajous, A. Monge, E. Ortiz-Panozo, E. Yunes, R. Lopez-Ridaura, G. Torres-Mejía, I. Romieu
    Cancer Causes & Control.2017; 28(9): 939.     CrossRef
  • SERS-based Immunoassay in a Microfluidic System for the Multiplexed Recognition of Interleukins from Blood Plasma: Towards Picogram Detection
    Agnieszka Kamińska, Katarzyna Winkler, Aneta Kowalska, Evelin Witkowska, Tomasz Szymborski, Anna Janeczek, Jacek Waluk
    Scientific Reports.2017;[Epub]     CrossRef
  • Infiltration of F98 glioma cells in Fischer rat brain is temporary stimulated by radiation
    Guillaume Desmarais, Gabriel Charest, Hélène Therriault, Minghan Shi, David Fortin, Rachel Bujold, David Mathieu, Benoit Paquette
    International Journal of Radiation Biology.2016; 92(8): 444.     CrossRef
  • Regulation of IL-20 Expression by Estradiol through KMT2B-Mediated Epigenetic Modification
    Chia-Hsin Su, I-Hsuan Lin, Tsai-Yu Tzeng, Wen-Ting Hsieh, Ming-Ta Hsu, Wei Xu
    PLOS ONE.2016; 11(11): e0166090.     CrossRef
  • Aggressive estrogen-receptor-positive breast cancer arising in patients with elevated body mass index
    Cesar Augusto Santa-Maria, Jingsheng Yan, Xian-Jin Xie, David Michael Euhus
    International Journal of Clinical Oncology.2015; 20(2): 317.     CrossRef
  • Interleukin-8 is associated with increased total mortality in women but not in men—findings from a community-based cohort of elderly
    Ilais Moreno Velásquez, Johan Ärnlöv, Karin Leander, Lars Lind, Bruna Gigante, Axel C. Carlsson
    Annals of Medicine.2015; 47(1): 28.     CrossRef
  • Type 2 Diabetes and Breast Cancer: The Interplay between Impaired Glucose Metabolism and Oxidant Stress
    Patrizia Ferroni, Silvia Riondino, Oreste Buonomo, Raffaele Palmirotta, Fiorella Guadagni, Mario Roselli
    Oxidative Medicine and Cellular Longevity.2015; 2015: 1.     CrossRef
  • Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration
    Kingsley O. Osuala, Mansoureh Sameni, Seema Shah, Neha Aggarwal, Michelle L. Simonait, Omar E. Franco, Yan Hong, Simon W. Hayward, Fariba Behbod, Raymond R. Mattingly, Bonnie F. Sloane
    BMC Cancer.2015;[Epub]     CrossRef
  • Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche
    Zach S. Templeton, Wen-Rong Lie, Weiqi Wang, Yael Rosenberg-Hasson, Rajiv V. Alluri, John S. Tamaresis, Michael H. Bachmann, Kitty Lee, William J. Maloney, Christopher H. Contag, Bonnie L. King
    Neoplasia.2015; 17(12): 849.     CrossRef
  • Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors
    Henry Thompson, Scot Sedlacek, Pamela Wolfe, Devchand Paul, Susan Lakoski, Mary Playdon, John McGinley, Shawna Matthews
    Nutrients.2015; 7(7): 5156.     CrossRef
  • Wound Healing and Cancer Stem Cells: Inflammation as a Driver of Treatment Resistance in Breast Cancer
    Kimberly M. Arnold, Lynn M. Opdenaker, Daniel Flynn, Jennifer Sims-Mourtada
    Cancer Growth and Metastasis.2015; 8: CGM.S11286.     CrossRef
  • Interleukin-6 as a Prognostic Marker for Breast Cancer: A Meta-analysis
    ShuChen Lin, ZhiHua Gan, Kun Han, Yang Yao, DaLiu Min
    Tumori Journal.2015; 101(5): 535.     CrossRef
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Evaluation of Prescribing Medications for Terminal Cancer Patients near Death: Essential or Futile
Hye Ran Lee, Seong Yoon Yi, Do Yeun Kim
Cancer Res Treat. 2013;45(3):220-225.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.220
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study is to evaluate the prescription of essential or futile medications for terminal cancer patients during their final admission.
MATERIALS AND METHODS
We conducted a retrospective review of the medical charts of terminally ill cancer patients admitted to the Hemato-oncology Department of two teaching hospitals from March 1, 2007 to December 31, 2009. Essential medications were based on the drugs listed by the International Association for Hospice and Palliative Care, while futile medications were defined when short-term benefit to patients with respect to survival, quality of life, or symptom control was not anticipated.
RESULTS
A total of 196 patients were included. Among essential medications, strong opioids were the most frequently prescribed drugs during the last admission (62.2% fentanyl, 44.3% morphine), followed by megestrol (46.0%), and metoclopramide (37.2%); 51% of gastric protectors were prescribed with potential futility. Anti-hypertensive and antiglycemic agents were administered to those who experienced arterial blood pressure below 90 mm Hg (47.3%) or presented with a single measurement of fasting glucose below 50 mg/dL (10.7%), respectively. Statins were prescribed to 6.1% (12/196) of patients, and 75% of those prescriptions were regarded as futile.
CONCLUSION
Our data suggest that effective prescription of essential medications and withdrawal from futile medications should be actively reconciled for improvement of a patient's end-of-life care.

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    João Luís Rodrigues-Ribeiro, Luísa Castro, Filipa Pinto-Ribeiro, Rui Nunes
    BMC Palliative Care.2024;[Epub]     CrossRef
  • Treatment patterns and out-of-hospital healthcare resource utilisation by patients with advanced cancer living with pain: An analysis from the Stop Cancer PAIN trial
    Nikki McCaffrey, Seong Leang Cheah, Tim Luckett, Jane L. Phillips, Meera Agar, Patricia M. Davidson, Frances Boyle, Tim Shaw, David C. Currow, Melanie Lovell, Ali Montazeri
    PLOS ONE.2023; 18(2): e0282465.     CrossRef
  • Examining Final-Administered Medication as a Measure of Data Quality: A Comparative Analysis of Death Data with the Central Cancer Registry in Republic of Korea
    Yae Won Tak, Jeong Hyun Han, Yu Jin Park, Do-Hoon Kim, Ji Seon Oh, Yura Lee
    Cancers.2023; 15(13): 3371.     CrossRef
  • Consultation-Based Deprescribing Service to Optimize Palliative Care for Terminal Cancer Patients
    Minoh Ko, Sunghwan Kim, Sung Yun Suh, Yoon Sook Cho, In-Wha Kim, Shin Hye Yoo, Ju-Yeun Lee, Jung Mi Oh
    Journal of Clinical Medicine.2023; 12(23): 7431.     CrossRef
  • Prescription Change in Older Adults Patients with End-Stage Cancer after Transition to Palliative Care
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    Korean Journal of Clinical Geriatrics.2023; 24(3): 115.     CrossRef
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    Tatiana Peralta, Maria Margarida Castel-Branco, Paulo Reis-Pina, Isabel Vitória Figueiredo, Marília Dourado
    BMC Palliative Care.2022;[Epub]     CrossRef
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    Palliative Medicine Reports.2022; 3(1): 279.     CrossRef
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    Hyeon Sik Yun, Youn Seon Choi, Su Hyun Kim, Yoo Jeong Lee, Jae young Park
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    Barbara Roux, Lucas Morin, Arnaud Papon, Marie-Laure Laroche
    European Geriatric Medicine.2019; 10(3): 463.     CrossRef
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    Patrick M. Zueger, Holly M. Holmes, Gregory S. Calip, Dima M. Qato, A. Simon Pickard, Todd A. Lee
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    Ferraz Gonçalves
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    Adam Todd, Andy Husband, Inga Andrew, Sallie-Anne Pearson, Laura Lindsey, Holly Holmes
    BMJ Supportive & Palliative Care.2017; 7(2): 113.     CrossRef
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    Marina Milic, Anna Foster, Karim Rihawi, Alan Anthoney, Chris Twelves
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    Nele J. Van Den Noortgate, Rebecca Verhofstede, Joachim Cohen, Ruth D. Piers, Luc Deliens, Tinne Smets
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  • Non-beneficial treatments in hospital at the end of life: a systematic review on extent of the problem
    M Cardona-Morrell, JCH Kim, RM Turner, M Anstey, IA Mitchell, K Hillman
    International Journal for Quality in Health Care.2016; 28(4): 456.     CrossRef
  • Deprescription in Advanced Cancer Patients Referred to Palliative Care
    Liliana Oliveira, Marta Oliveira Ferreira, Alexandre Rola, Miguel Magalhães, José Ferraz Gonçalves
    Journal of Pain & Palliative Care Pharmacotherapy.2016; 30(3): 201.     CrossRef
  • Polypharmacy among inpatients aged 70 years or older in Australia
    Ruth E Hubbard, Nancye M Peel, Ian A Scott, Jennifer H Martin, Alesha Smith, Peter I Pillans, Arjun Poudel, Leonard C Gray
    Medical Journal of Australia.2015; 202(7): 373.     CrossRef
  • Prescribing for older people discharged from the acute sector to residential aged‐care facilities
    P. Hopcroft, N. M. Peel, A. Poudel, I. A. Scott, L. C. Gray, R. E. Hubbard
    Internal Medicine Journal.2014; 44(10): 1034.     CrossRef
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Psychosocial Impact of Cancer Patients on Their Family Members
Sun Min Lim, Hyeon Chang Kim, Soohyeon Lee
Cancer Res Treat. 2013;45(3):226-233.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.226
AbstractAbstract PDFPubReaderePub
PURPOSE
A population-based study was conducted in order to examine the characteristics of family members of cancer patients in comparison with the general population and also to evaluate the psychosocial impact of cancer patients on their family members.
MATERIALS AND METHODS
From the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) (2007-2009) dataset, we identified 460 cancer patients and then selected family members of these patients who were aged 20 years or older (n=565). The control group was sampled from members of families without a cancer patient with matching for sex and age (n=2,260). Serial conditional logistic regression models were used for comparison of characteristics between family members of cancer patients and subjects in the control group.
RESULTS
Family members of cancer patients were less employed (57.9% vs. 63.0%, p<0.001), more functionally limited (20.2% vs. 16.5%, p=0.032), and had lower self-rated health (p=0.023) compared with sex and age-matched control subjects. They also had a significantly higher level of stress (79.7% vs. 76.1%, p=0.008), history of depression (12.9% vs. 10.2%, p=0.035), and current depressive symptoms (5.5% vs. 3.5%, p=0.038). However, higher physical activity was reported in family members of cancer patients (13.6% vs. 9.6%, p=0.003) than in control subjects. The presence of a cancer patient in the family showed an association with current depressive symptoms (odds ratio, 1.62; 95% confidence interval, 1.05 to 2.48; p=0.028), however, the association was no longer significant after adjustment for household income, education level, and employment status (p=0.304).
CONCLUSION
Family members of cancer patients are more susceptible to depression, probably due to adverse change in socioeconomic status. Use of multidisciplinary approaches for promotion of psychological health and well-being is essential.

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    Rod Carlo Columbres, Erin Jay G. Feliciano, Kathleen Joy Taleon-Tampo, Katelyn Edelwina Y. Legaspi, Michelle Ann B. Eala, Kenrick Ng, Fumiko Chino, Frederic Ivan L. Ting, Edward Christopher Dee
    The Lancet Regional Health - Western Pacific.2024; 47: 101114.     CrossRef
  • Financial Sequelae of Cancer for Patients' Family Members and Caregivers: A Focus on the Philippines
    Rod Carlo Columbres, Erin Jay G. Feliciano, Lance Isidore Catedral, Jose Ma. H. Zaldarriaga, Michelle Ann B. Eala, Jerickson Abbie Flores, Enrico D. Tangco, Narjust Florez, Frederic Ivan L. Ting, Edward Christopher Dee
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    Jean-François Stephan, Sani Karam
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    Iago Dillion Lima Cavalcanti, Diogo Timóteo Costa, José Cleberson Santos Soares, Mariane Cajubá de Britto Lira Nogueira
    Journal of Religion and Health.2023; 62(3): 1998.     CrossRef
  • Association between changes in having of cancer patients in the family and depression: A longitudinal panel study
    Yun Seo Jang, Na-Young Yoon, Kyungduk Hurh, Eun-Cheol Park, Min Jin Ha
    Journal of Affective Disorders.2023; 333: 482.     CrossRef
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    Normarie Torres Blasco, Rosario Costas Muñiz, Carolina Zamore, Laura Porter, Maria Claros, Guillermo Bernal, Megan Johnson Shen, William Breitbart, EM Castro
    BMJ Open.2022; 12(4): e045487.     CrossRef
  • Unmet supportive care needs of caregivers according to medical settings of cancer patients: a cross-sectional study
    Véronique Christophe, Amelie Anota, Laurence Vanlemmens, Alexis Cortot, Tatiana Ceban, Guillaume Piessen, Emilie Charton, Anne-Sophie Baudry
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    Yie Lin Lew, Fuad Ismail, Siti Azdiah Abdul Aziz, Noraida Mohamed Shah
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    Li-Ping Wong, Yek-Ching Kong, Nanthini Thevi Bhoo-Pathy, Shridevi Subramaniam, Ros Suzanna Bustamam, Nur Aishah Taib, Gwo-Fuang Ho, Hafizah Zaharah, Matin Mellor, Yin-Ling Woo, Cheng-Har Yip, Nirmala Bhoo-Pathy
    JCO Oncology Practice.2021; 17(4): e548.     CrossRef
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    Valerio Nardone, Alfonso Reginelli, Claudia Vinciguerra, Pierpaolo Correale, Maria Grazia Calvanese, Sara Falivene, Angelo Sangiovanni, Roberta Grassi, Angela Di Biase, Maria Angela Polifrone, Michele Caraglia, Salvatore Cappabianca, Cesare Guida
    Frontiers in Psychology.2021;[Epub]     CrossRef
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  • Supportive care needs: An aspect of Thai women with breast cancer undergoing chemotherapy
    Supanee Klungrit, Sureeporn Thanasilp, Chanokporn Jitpanya
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    Anne-Sophie Baudry, Laurence Vanlemmens, Amelie Anota, Alexis Cortot, Guillaume Piessen, Veronique Christophe
    European Journal of Oncology Nursing.2019; 43: 101669.     CrossRef
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  • Family Members of Cancer Patients in Korea Are at an Increased Risk of Medically Diagnosed Depression
    Youngdae Cho, Yongwoo Jeon, Sung-In Jang, Eun-Cheol Park
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    Kyung-Hyun Choi, Sang Min Park
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  • High-risk smoldering myeloma: Perspective on watchful monitoring
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Case Reports
A Rare Presentation of Follicular Lymphoma: Cerebellar Involvement, Successfully Treated with a Combination of Radiotherapy and Chemotherapy
Nuri Karadurmus, Selmin Ataergin, Gokhan Erdem, Mustafa Cakar, Ozdes Emer, Sukru Ozaydin, Mustafa Ozturk, Mukerrem Safali, Fikret Arpaci
Cancer Res Treat. 2013;45(3):234-238.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.234
AbstractAbstract PDFPubReaderePub
The central nervous system (CNS) is an important area of involvement for both high-grade, aggressive primary and secondary lymphomas. Although follicular lymphoma represents a low-grade histology, it may rarely present with CNS involvement. Here, we describe a patient diagnosed with follicular lymphoma who was presented with cerebellar involvement.

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  • Follicular lymphoma with secondary central nervous system relapse: a case report and literature review
    Yuri Tsuboi, Misayo Shimizu, Akihiro Kuroda, Takuya Suyama, Masanori Seki, Atsushi Shinagawa
    Oxford Medical Case Reports.2023;[Epub]     CrossRef
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    Furqaan Ahmed Kaji, Nicolás Martinez‐Calle, Vishakha Sovani, Christopher Paul Fox
    British Journal of Haematology.2022; 197(6): 662.     CrossRef
  • Secondary parenchymal CNS involvement by lymphoma including rare types: Follicular and EBV-positive NK/T cell lymphoma, nasal type
    B.K. Kleinschmidt-DeMasters, Ahmed Gilani
    Annals of Diagnostic Pathology.2021; 53: 151765.     CrossRef
  • Cerebral Amyloidoma Resulting from Central Nervous System Lymphoplasmacytic Lymphoma: A Case Report and Literature Review
    Geetha Jagannathan, Guldeep Uppal, Kevin Judy, Mark T. Curtis
    Case Reports in Pathology.2018; 2018: 1.     CrossRef
  • Sites of extranodal involvement are prognostic in patients with stage 1 follicular lymphoma
    Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S. Londono, Amit K. Verma, Stefan K. Barta
    Oncotarget.2017; 8(45): 78410.     CrossRef
  • Follicular Lymphoma Presenting with Leptomeningeal Disease
    Rubens Costa, Ricardo Costa, Renata Costa
    Case Reports in Hematology.2014; 2014: 1.     CrossRef
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  • 96 Download
  • 6 Crossref
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Angiomatoid Fibrous Histiocytoma as a Second Tumor in a Young Adult with Testicular Cancer
Han-Sang Lee, Taewan Kim, Jin-Sook Kim, Hye Ran Lee, Mee Joo, Ji Yeon Park, Seong Yoon Yi
Cancer Res Treat. 2013;45(3):239-243.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.239
AbstractAbstract PDFPubReaderePub
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, with a low-grade malignant potential, occurring predominantly in children and young adults. Association between AFH and other malignancies has been rarely reported. A 27-year-old man who presented with a palpable abdominal mass was diagnosed as having testicular cancer with multiple liver and lung metastases. At 16 months after chemotherapy, a follow-up computed tomographic scan revealed a supraclavicular mass measuring 3 cm in size, which was suspected to be a recurrence. The patient underwent surgical excision, and the mass was pathologically diagnosed as a AFH. The patient has had no local recurrence and no distant metastasis for 12 months after resection. To the best of our knowledge, this is the first case report of AFH as a second tumor in a patient with testicular cancer.

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    British Journal of Neurosurgery.2023; 37(5): 1069.     CrossRef
  • Endobronchial Primary Pulmonary Angiomatoid Fibrous Histiocytoma in a Patient with Testicular Germ Cell Tumor: An Evidence Against Somatic Transformation
    Mehmet Çetin, Kubra Katipoglu, İlteriş Türk, Şeref Özkara, Kemal Kosemehmetoglu, Pınar Bıçakçıoğlu
    International Journal of Surgical Pathology.2022; 30(6): 662.     CrossRef
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    Gerardo Cazzato, Anna Colagrande, Antonietta Cimmino, Mariella Silecchia, Teresa Lettini, Leonardo Resta, Giuseppe Ingravallo
    Osteology.2021; 1(3): 112.     CrossRef
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    Chee Kiang Tay, Mariko Siyue Koh, Angela Takano, Marie Christine Aubry, William R. Sukov, Andrew L. Folpe
    Human Pathology.2016; 58: 134.     CrossRef
  • Angiomatoid Fibrous Histiocytoma: The Current Status of Pathology and Genetics
    Khin Thway, Cyril Fisher
    Archives of Pathology & Laboratory Medicine.2015; 139(5): 674.     CrossRef
  • Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation
    Ali Yikilmaz, Bo-Yee Ngan, Oscar M. Navarro
    Pediatric Radiology.2015; 45(12): 1796.     CrossRef
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  • 54 Download
  • 6 Crossref
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Successful Treatment by Chemotherapy of Pineal Parenchymal Tumor with Intermediate Differentiation: A Case Report
Ji-won Yi, Hyo-jeong Kim, Young-jin Choi, Young-mi Seol, Dong-hwahn Kahng, Yu-yi Choi, Eun-kyoung Park
Cancer Res Treat. 2013;45(3):244-249.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.244
AbstractAbstract PDFPubReaderePub
A 37-year-old male presented with a mass measuring 2.5 cm in size in the midbrain and obstructive hydrocephalus, which had manifested as a headache and dizziness. Magnetic resonance (MR) imaging of the brain showed intermediate enhancement on T1-weighted MR imaging and a high intensity of enhancement on T2-weighted MR. Neurosurgeons performed an occipital craniotomy with partial removal of the tumor and the postoperative diagnosis was a pineal parenchymal tumor with intermediate differentiation. He had undergone irradiation with 54 Gy of radiation on 27 fractions for removal of the remaining tumor approximately one month after surgery. However, in follow-up imaging performed four months after radiotherapy, a remnant mass in the superoposterior aspect of the midbrain was found to have extended to the hypothalamus and the third ventricle. He was treated with six cycles of procarbazine, lomustine, vincristine chemotherapy. At five months since the completion of chemotherapy, the brain MR imaging showed no evidence of any remaining tumor and he no longer displayed any of his initial symptoms.

Citations

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  • Radiation therapy for pineal parenchymal tumor of intermediate differentiation: A case series and literature review
    Cassie Liu, Joseph Carmicheal, Michael J. Baine, Chi Zhang
    Journal of Central Nervous System Disease.2023;[Epub]     CrossRef
  • Survival and Malignant Transformation of Pineal Parenchymal Tumors: A 30-Year Retrospective Analysis in a Single-Institution
    Tae-Hwan Park, Seung-Ki Kim, Ji Hoon Phi, Chul-Kee Park, Yong Hwy Kim, Sun Ha Paek, Chang-Hyun Lee, Sung-Hye Park, Eun Jung Koh
    Brain Tumor Research and Treatment.2023; 11(4): 254.     CrossRef
  • Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades
    Hajime Takase, Reo Tanoshima, Navneet Singla, Yoshihiko Nakamura, Tetsuya Yamamoto
    Neurosurgical Review.2022; 45(2): 1135.     CrossRef
  • Survival and associated predictors for patients with pineoblastoma or pineal parenchymal tumors of intermediate differentiation older than 3 years: Insights from the National Cancer Database
    Panagiotis Kerezoudis, Yagiz Ugur Yolcu, Nadia N Laack, Michael W Ruff, Soumen Khatua, David J Daniels, Terry C Burns, Sani H Kizilbash
    Neuro-Oncology Advances.2022;[Epub]     CrossRef
  • Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) and Papillary Tumor of Pineal Region (PTPR)
    Nishanth Sadashiva, Harsh Deora, Kirit Arumalla, Shilpa Rao, Jitender Saini, Dhaval Shukla, Vani Santosh
    Neurology India.2021; 69(5): 1153.     CrossRef
  • Revisiting the pineal gland: a review of calcification, masses, precocious puberty, and melatonin functions
    Shrey Patel, Benjamin Rahmani, Jason Gandhi, Omar Seyam, Gunjan Joshi, Inefta Reid, Noel L. Smith, Wayne C. Waltzer, Sardar Ali Khan
    International Journal of Neuroscience.2020; 130(5): 464.     CrossRef
  • Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation
    Debajyoti Chatterjee, Khushboo Lath, Navneet Singla, Narendra Kumar, Bishan D. Radotra
    Applied Immunohistochemistry & Molecular Morphology.2019; 27(3): 210.     CrossRef
  • The Higher the Grade, the Bigger the Field
    Jason M. Beckta, Ranjit S. Bindra
    International Journal of Radiation Oncology*Biology*Physics.2018; 102(3): 488.     CrossRef
  • Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation
    Yun Jee Kang, Wenya Linda Bi, Adrian M. Dubuc, Louine Martineau, Azra H. Ligon, Aaron L. Berkowitz, Ayal A. Aizer, Eudocia Q. Lee, Keith L. Ligon, Shakti H. Ramkissoon, Ian F. Dunn
    World Neurosurgery.2016; 85: 96.     CrossRef
  • Twenty-seven cases of pineal parenchymal tumours of intermediate differentiation: mitotic count, Ki-67 labelling index and extent of resection predict prognosis
    Tao Yu, Xingwen Sun, Junmei Wang, Xiaohui Ren, Ning Lin, Song Lin
    Journal of Neurology, Neurosurgery & Psychiatry.2016; 87(4): 386.     CrossRef
  • Revisiting the metastatic potential of childhood pineal parenchymal tumor of intermediate differentiation: a case report
    Navneet Singla, Ankur Kapoor, Sivashanmugam Dhandapani, B. D. Radotra, Debajyoti Chatterjee
    Child's Nervous System.2016; 32(7): 1183.     CrossRef
  • An Unusual Variant of Anlage Tumor of Pineal Region in an Infant
    Raghvendra Ramdasi, Kanchan Kothari, Naina Goel, Amit Mahore
    Brain Tumor Research and Treatment.2015; 3(1): 52.     CrossRef
  • Diffusion characteristics of pediatric pineal tumors
    Asim F Choudhri, Matthew T Whitehead, Adeel Siddiqui, Paul Klimo, Frederick A Boop
    The Neuroradiology Journal.2015; 28(2): 209.     CrossRef
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