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Volume 45(1); March 2013
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Special Articles
Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hong Gwan Seo, Jin-Soo Lee
Cancer Res Treat. 2013;45(1):1-14.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.1
AbstractAbstract PDFPubReaderePub
PURPOSE
This article gives an overview of nationwide cancer statistics, including incidence, mortality, survival and prevalence, and their trends in Korea based on 2010 cancer incidence data.
MATERIALS AND METHODS
Incidence data from 1993 to 2010 were obtained from the Korea National Cancer Incidence Database, and vital status was followed until 31 December 2011. Mortality data from 1983 to 2010 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, prevalence, and relative survival were calculated.
RESULTS
In total, 202,053 cancer cases and 72,046 cancer deaths occurred during 2010, and 960,654 prevalent cancer cases were identified in Korea as of 1 January 2011. The incidence of all cancers combined showed an annual increase of 3.3% from 1999 to 2010. The incidences of liver and cervical cancers have decreased while those of thyroid, breast, prostate and colorectal cancers have increased. Notably, thyroid cancer, which is the most common cancer in Korea, increased by 24.2% per year rapidly in both sexes. The mortality of all cancers combined showed a decrease by 2.7% annually from 2002 to 2010. Five-year relative survival rates of patients who were diagnosed with cancer from 2006 to 2011 had improved by 22.9% compared with those from 1993 to 1995.
CONCLUSION
While the overall cancer incidence in Korea has increased rapidly, age-standardized cancer mortality rates have declined since 2002 and survival has improved.

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    The Journal of Alternative and Complementary Medicine.2015; 21(4): 217.     CrossRef
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    Jaeyong Shin, Eun-Cheol Park, Hong-Chul Bae, Seri Hong, Suk-Yong Jang, Jae-Hyun Kim, Jee Suk Chang, Sang Gyu Lee
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  • Screening Prostate-specific Antigen Concentration and Prostate Cancer Mortality: The Korean Heart Study
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    Breast Cancer Research and Treatment.2015; 152(1): 147.     CrossRef
  • Incidence of kidney, bladder, and prostate cancers in Korea: An update
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  • Overexpressions of Vimentin and Integrins in Human Metastatic Spine Tumors
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  • Thyroid Cancer and Radiation
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  • All-or-(N)One – an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci
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  • Effects of adjuvant radiotherapy on completely resected gastric cancer: A radiation oncologist’s view of the ARTIST randomized phase III trial
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  • The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
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  • Anticancer activity of CopA3 dimer peptide in human gastric cancer cells
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  • Ten-Year Changes in the Hepatitis B Prevalence in the Birth Cohorts in Korea
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  • Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009
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  • Reliability and Validity of the Korean Version of the Modified Adult Attachment Scale for the Use of Medically Ill Patients
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  • Multiple cores of high grade prostatic intraepithelial neoplasia and any core of atypia on first biopsy are significant predictor for cancer detection at a repeat biopsy
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  • Diagnostic Thyroidectomy May Be Preferable in Patients With Suspicious Ultrasonography Features After Cytopathology Diagnosis of AUS/FLUS in the Bethesda System
    Yong Sang Lee, Hyeung Kyoo Kim, Hojin Chang, Seok Mo Kim, Bup-Woo Kim, Hang-Seok Chang, Cheong Soo Park
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  • Influences of Symptom Experience and Depression on Quality of Life in Colorectal Cancer Patients with Stoma Reversal
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    International Journal of Environmental Research and Public Health.2015; 12(8): 10133.     CrossRef
  • Interactions between Paraoxonase 1 Genetic Polymorphisms and Smoking and Their Effects on Oxidative Stress and Lung Cancer Risk in a Korean Population
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Prediction of Cancer Incidence and Mortality in Korea, 2013
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hong Gwan Seo, Jin-Soo Lee
Cancer Res Treat. 2013;45(1):15-21.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.15
AbstractAbstract PDFPubReaderePub
PURPOSE
To estimate the current cancer burden in Korea, cancer incidence and mortality rates were projected for the year 2013.
MATERIALS AND METHODS
Cancer incidence data from 1999 to 2010 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2011 were obtained from Statistics Korea. Cancer incidence in 2013 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. For cancer mortality, a similar procedure was used, except that a Joinpoint regression model was used to determine at which year the linear trend changed significantly.
RESULTS
In total, 247,732 new cancer cases and 74,179 cancer deaths are projected to occur in Korea in 2013. For all sites combined, the crude incidence rates are projected to be 489.8 and 492.2, and the age-standardized incidences to be 350.4 and 318.4 per 100,000 for males and females, respectively.
CONCLUSION
Cancer has become an important public health concern in Korea, and as the Korean population ages, the cancer burden will continue to increase.

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Original Articles
Response Evaluation after Neoadjuvant Chemoradiation by Positron Emission Tomography-Computed Tomography for Esophageal Squamous Cell Carcinoma
Joon Suk Park, Joon Young Choi, Seung Hwan Moon, Yong Chan Ahn, Jeeyun Lee, Dohun Kim, Kwhanmien Kim, Young Mog Shim
Cancer Res Treat. 2013;45(1):22-30.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.22
AbstractAbstract PDFPubReaderePub
PURPOSE
Parameters of positron emission tomography-computed tomography (PET-CT) were compared with the results of histopathologic examination in order to determine which can provide an objective indication of response after neoadjuvant chemoradiation for treatment of thoracic esophageal squamous cell carcinoma (SCC).
MATERIALS AND METHODS
Between August 2003 and January 2010, data on 25 patients who underwent neoadjuvant chemoradiation and subsequent resection for treatment of esophageal SCC were retrospectively reviewed. Changes in maximum standardized uptake value (DeltaSUVmax), metabolic tumor volume (DeltaMTV), and total lesion glycolysis (DeltaTLG) were analyzed by comparison with the histopathologic findings.
RESULTS
Pathologic complete remission (CR) for the main tumor was achieved in 11 patients. Postradiation esophagitis was observed in 10 patients. DeltaSUVmax of the main tumor was significantly greater in the CR group than in the partial response (PR) group (p=0.039), while DeltaMTV and DeltaTLG of the main tumor were not (p=0.141 and p=0.349, respectively). The cut-off DeltaSUVmax value for CR was estimated as 72.1%, indicating significantly better accuracy than visual interpretation (p=0.045). Of the 48 involved lymph nodes, DeltaSUVmax and DeltaMTV of lymph nodes were significantly greater in the CR group than in the PR group (p=0.045 and p=0.014, respectively), while DeltaTLG was not (p=0.063). The cut-off value of DeltaSUVmax for prediction of CR in lymph nodes was calculated as 50.67%.
CONCLUSION
PET-CT could be used for prediction of response to neoadjuvant treatment in thoracic esophageal SCC. DeltaSUVmax may be a more significant predictor for CR after neoadjuvant chemoradiation than DeltaTLG and DeltaMTV.

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Adjuvant Postoperative Radiotherapy with or without Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: The Importance of Patient Selection for the Postoperative Chemoradiotherapy
Jong Hoon Lee, Jin Ho Song, Sang Nam Lee, Jin Hyoung Kang, Min Sik Kim, Dong Il Sun, Yeon-Sil Kim
Cancer Res Treat. 2013;45(1):31-39.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.31
AbstractAbstract PDFPubReaderePub
PURPOSE
We wanted to evaluate the role of postoperative chemoradiotherapy (CRT) for patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).
MATERIALS AND METHODS
From March 1993 to July 2008, 101 patients with advanced SCCHN and who had undergone macroscopically complete resection were enrolled. Survival and the cumulative incidence of local or regional relapse, metastasis, and acute toxicity were analyzed.
RESULTS
There was a marginally significant difference of disease-free survival at five years in favor of the CRT arm (51.3% vs. 41.8%, respectively; p=0.10). However, there was no significant difference in overall survival between the two treatment arms (p=0.20). The rate of locoregional failure only for the radiotherapy arm was significantly higher than that for the CRT arm (23.2% vs. 4.4%, respectively; p=0.01). The incidence of grade 3 or 4 hematologic toxicity was significantly higher in the CRT arm than that in the radiotherapy arm (37.7% vs. 1.7%, respectively; p=0.01). In CRT arm, early mortality group within 1 year had low performance status and old age over sixty compared with those of the others.
CONCLUSION
After curative-intent surgery, adjuvant CRT is more effective in locoregional tumor control than radiotherapy alone for patients with advanced SCCHN. However, compared with radiotherapy alone, this combined modality treatment had no survival benefit, and was significantly associated with increased toxicity. Thus, patients with low performance status and old age must be cautious in selection of toxic trimodality treatment.

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Feasibility of Oxaliplatin, Leucovorin, and 5-Fluorouracil (FOLFOX-4) Chemotherapy in Heavily Pretreated Patients with Recurrent Epithelial Ovarian Cancer
Hee Jun Lee, Hee Seung Kim, Noh Hyun Park, Hyun Hoon Chung, Jae Weon Kim, Yong Sang Song
Cancer Res Treat. 2013;45(1):40-47.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.40
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study is to evaluate the efficacy and toxicity of oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX-4) chemotherapy in heavily pretreated patients with recurrent epithelial ovarian cancer (EOC).
MATERIALS AND METHODS
Clinical data were reviewed in 28 patients who received FOLFOX-4 as more than the second-line chemotherapy, consisting of 85 mg/m2 of oxaliplatin as a 2-hour infusion, 200 mg/m2 of leucovorin as a 2-hour infusion, and bolus 400 mg/m2 on day 1, followed by a 22-hour infusion of 600 mg/m2 of 5-fluorouracil for two consecutive days every three weeks. In addition, its efficacy and toxicity were compared with those reported in in three previous relevant studies.
RESULTS
A total of 128 cycles of FOLFOX-4 were administered with the median number of five cycles (range, 1 to 10 cycles). In nine patients with measurable disease, complete response (CR) and partial response (PR) were observed in 0 (0%) and two (22.2%) patients, whereas in 19 patients with non-measurable disease, CR and PR were observed in 0 (0%) and five (26.3%) patients. Among all patients, grade 3 anemia, neutropenia, and thrombocytopenia were observed in two (7.1%), three (10.7%), and one (3.6%) patient, and grade 3 fatigue, nausea and vomiting, and peripheral neuropathy were observed in one (3.6%), two (7.1%), and three (10.7%) patients. In addition, median values of time to progressive disease and chemotherapy-specific survival were three months (range, 0 to 10 months) and nine months (range, 4 to 24 months).
CONCLUSION
FOLFOX-4 is feasible as salvage chemotherapy with acceptable toxicity for heavily pretreated patients with recurrent EOC.

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Prognostic Value of Different Patterns of Squamous Cell Carcinoma Antigen Level for the Recurrent Cervical Cancer
Bae Kwon Jeong, Seung Jae Huh, Doo Ho Choi, Won Park, Duk Soo Bae, Byoung-Gie Kim
Cancer Res Treat. 2013;45(1):48-54.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.48
AbstractAbstract PDFPubReaderePub
PURPOSE
In some unusual cases, in patients with cervical cancer, an elevation of squamous cell carcinoma antigen (SCC-Ag) was not observed at diagnosis but was observed on recurrence, or vice versa. The objective of this study was to identify patient-, disease-, and treatment-related factors associated with this unusual level of SCC-Ag, and to determine whether SCC-Ag is a useful tumor marker in such patients.
MATERIALS AND METHODS
Among 129 patients with recurrence, 14 who showed a normal SCC-Ag level at diagnosis but an elevated level at recurrence were classified as group I; 22 patients with an elevated SCC-Ag level at diagnosis but not at recurrence were classified as group II; and 76 patients with an elevated SCC-Ag level at both diagnosis and recurrence were classified as group III.
RESULTS
In univariate analysis, unusual SCC-Ag showed statistically significant relationships with pathology and biochemical response to treatment. However, in the multivariate analysis, none of the clinicopathologic factors showed a statistical relationship with unusual levels of SCC-Ag. The 5-year disease-free survival rates for groups I, II, and III were 7.1%, 9.1%, and 0% (p=0.418), and the 5-year overall survival rates were 34.3%, 58.4%, and 33.3% (p=0.142), respectively.
CONCLUSION
The value of SCC-Ag has been confirmed in all patients; thus, check of SCC-Ag level at follow-up should be considered. Although no statistically significant differences were observed among the groups, we conclude that patients with a high initial SCC-Ag and elevated SCC-Ag at relapse have poor prognosis due to high SCC-Ag level.

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Impact of KRAS Mutation Status on Outcomes in Metastatic Colon Cancer Patients without Anti-Epidermal Growth Factor Receptor Therapy
Seung Tae Kim, Kyong Hwa Park, Jun Suk Kim, Sang Won Shin, Yeul Hong Kim
Cancer Res Treat. 2013;45(1):55-62.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.55
AbstractAbstract PDFPubReaderePub
PURPOSE
Activating mutation of the KRAS oncogene is an established negative predictor for anti-epidermal growth factor receptor (anti-EGFR) therapies in metastatic colorectal cancer (CRC). However, KRAS mutation as a prognostic factor of survival outcome remains controversial in CRC, independent of anti-EGFR therapies.
MATERIALS AND METHODS
We conducted a retrospective analysis of 103 CRC patients who were available for evaluation of KRAS mutation status. None of the patients analyzed had received anti-EGFR therapies. The role of KRAS mutation status was evaluated as a predictive factor for oxaliplatin or irinotecan and as a prognostic factor in CRC patients who did not receive anti-EGFR therapies.
RESULTS
Mutations in KRAS were observed in 48.5% of patients. The response for oxaliplatin- (p=0.664) and irinotecan-based (p=0.255) cytotoxic chemotherapy did not differ according to the KRAS mutation status. In addition, no significant difference in progression free survival (PFS; oxaliplatin, p=0.583 and irinotecan, p=0.426) and overall survival (OS; p=0.258) was observed between the wild and mutant type of the KRAS gene. In univariate and multivariate analyses, KRAS mutations did not have a major prognostic value regarding PFS (oxaliplatin: hazard ratio, 0.892; 95% confidence interval [CI], 0.590 to 1.347; p=0.586 and irinotecan: hazard ratio, 0.831; 95% CI, 0.524 to 1.319; p=0.433) or OS (hazard ratio, 0.754; 95% CI, 0.460 to 1.236; p=0.263). In addition, anti-vascular endothelial growth factor therapies did not affect PFS to oxaliplatin or irinotecan and OS.
CONCLUSION
KRAS mutation is not a prognostic marker for PFS to oxaliplatin or irinotecan and OS in CRC patients who did not receive anti-EGFR therapies.

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  • Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases
    Hiroaki Niitsu, Takao Hinoi, Manabu Shimomura, Hiroyuki Egi, Minoru Hattori, Yasuyo Ishizaki, Tomohiro Adachi, Yasufumi Saito, Masashi Miguchi, Hiroyuki Sawada, Masatoshi Kochi, Shoichiro Mukai, Hideki Ohdan
    World Journal of Surgical Oncology.2015;[Epub]     CrossRef
  • KRAS Status as an Independent Prognostic Factor for Survival after Yttrium-90 Radioembolization Therapy for Unresectable Colorectal Cancer Liver Metastases
    Steven J. Lahti, Minzhi Xing, Di Zhang, James J. Lee, Michael J. Magnetta, Hyun S. Kim
    Journal of Vascular and Interventional Radiology.2015; 26(8): 1102.     CrossRef
  • Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian patients with metastatic colorectal cancer
    LEE CHENG PHUA, HUI WEN NG, ANGIE HUI LING YEO, ELYA CHEN, MICHELLE SHU MEI LO, PEH YEAN CHEAH, ERIC CHUN YONG CHAN, POH KOON KOH, HAN KIAT HO
    Oncology Letters.2015; 10(4): 2519.     CrossRef
  • Characterization of rare transformingKRASmutations in sporadic colorectal cancer
    Joanna HM Tong, Raymond WM Lung, Frankie MC Sin, Peggy PY Law, Wei Kang, Anthony WH Chan, Brigette BY Ma, Tony WC Mak, Simon SM Ng, Ka Fai To
    Cancer Biology & Therapy.2014; 15(6): 768.     CrossRef
  • Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer
    Alfonso De Stefano
    World Journal of Gastroenterology.2014; 20(29): 9732.     CrossRef
  • RAS mutations: impact on treatment outcome
    Sameh Mikhail, Tanios Bekaii-Saab
    Colorectal Cancer.2013; 2(6): 525.     CrossRef
  • The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer
    Ching-Wen Huang, Hsiang-Lin Tsai, Yi-Ting Chen, Chun-Ming Huang, Cheng-Jen Ma, Chien-Yu Lu, Chao-Hung Kuo, Deng-Chyang Wu, Chee-Yin Chai, Jaw-Yuan Wang
    BMC Cancer.2013;[Epub]     CrossRef
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ERCC1 Can Be a Prognostic Factor in Hilar Cholangiocarcinoma and Extrahepatic Bile Duct Cancer, But Not in Intrahepatic Cholangiocarcinoma
Kyun Woo Park, Eun-Seon Jung, Dong-Gu Kim, Young-Kyung Yoo, Tae-Ho Hong, In Seok Lee, Yoon Ho Koh, Ji-Hoon Kim, Myung Ah Lee
Cancer Res Treat. 2013;45(1):63-69.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.63
AbstractAbstract PDFPubReaderePub
PURPOSE
There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC), hilar cholangiocarcinoma (HC), and extrahepatic cholangiocarcinoma (EHC). Despite different clinical presentation, the same protocol has been used in treatment of patients with these cancers. We analyzed clinicopathologic findings and protein expression in order to investigate the difference and the specific prognostic factors among these three types of cancers.
MATERIALS AND METHODS
We conducted a retrospective review of 104 patients diagnosed with bile duct cancer at Seoul St. Mary's Hospital between January 1994 and May 2004. We performed immunohistochemical staining for p53, cyclin D1, thymidine phosphorylase, survivin, and excision repair cross-complementing group 1 (ERCC1).
RESULTS
Of the 104 patients, EHC was most common (44.2%). In pathologic findings, perineural invasion was significantly less common in ICC. Overall survival was similar among the three types of cancer. Lymph node invasion, lymphatic, and venous invasion showed a significant association with survival outcome in ICC, however, the differentiation of histologic grade had prognostic significance in HC and EHC. No difference in protein expression was observed among these types of cancer, however, ERCC1 showed a significant association with survival outcome in HC and EHC, not in ICC.
CONCLUSION
Based on our data, ICC showed different characteristics and prognostic factors, separate from the other two types of bile duct cancer. Conduct of further studies with a large sample size is required in order to confirm these data.

Citations

Citations to this article as recorded by  
  • Systematic Review of Preoperative Prognostic Biomarkers in Perihilar Cholangiocarcinoma
    Rishaan Pawaskar, Kevin Zhang Huang, Helen Pham, Adnan Nagrial, Mark Wong, Siobhan O’Neill, Henry Pleass, Lawrence Yuen, Vincent W. T. Lam, Arthur Richardson, Tony Pang, Christopher B. Nahm
    Cancers.2024; 16(4): 698.     CrossRef
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    Tai-Jan Chiu, Yueh-Wei Liu, Chee-Chien Yong, Shih-Min Yin, Cheng-His Yeh, Yen-Yang Chen
    Cancers.2023; 15(22): 5474.     CrossRef
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    Nikolaos Charalampakis, Georgios Papageorgiou, Sergios Tsakatikas, Rodanthi Fioretzaki, Christo Kole, Stylianos Kykalos, Maria Tolia, Dimitrios Schizas
    Immunotherapy.2021; 13(13): 1113.     CrossRef
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    Andrea Ruzzenente, Matteo Fassan, Simone Conci, Michele Simbolo, Rita T. Lawlor, Corrado Pedrazzani, Paola Capelli, Mirko D’Onofrio, Calogero Iacono, Aldo Scarpa, Alfredo Guglielmi
    Annals of Surgical Oncology.2016; 23(5): 1699.     CrossRef
  • Intracellular autocrine VEGF signaling promotes EBDC cell proliferation, which can be inhibited by Apatinib
    Sui Peng, Yanyan Zhang, Hong Peng, Zunfu Ke, Lixia Xu, Tianhong Su, Allan Tsung, Samer Tohme, Hai Huang, Qiuyang Zhang, Riccardo Lencioni, Zhirong Zeng, Baogang Peng, Minhu Chen, Ming Kuang
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    Heidi D. Lehrke, Julie K. Heimbach, Tsung-Teh Wu, Sarah M. Jenkins, Gregory J. Gores, Charles B. Rosen, Taofic Mounajjed
    American Journal of Surgical Pathology.2016; 40(4): 510.     CrossRef
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    Muhtashim Mian, Mairéad G McNamara, Mark Doherty, David Hedley, Jennifer J Knox, Stefano Serra
    Journal of Clinical Pathology.2016; 69(8): 695.     CrossRef
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    Hong Peng, Qiuyang Zhang, Jiali Li, Ning Zhang, Yunpeng Hua, Lixia Xu, Yubin Deng, Jiaming Lai, Zhenwei Peng, Baogang Peng, Minhu Chen, Sui Peng, Ming Kuang
    Oncotarget.2016; 7(13): 17220.     CrossRef
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Case Reports
A Case Report of Paraneoplastic Pemphigus Associated with Esophageal Squamous Cell Carcinoma
Jin Hyun Cho, Nam Jun Kim, Sung Min Ko, Chunghun Kim, Hee Kyung Ahn, Jina Yun, Yeon Hee Park
Cancer Res Treat. 2013;45(1):70-73.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.70
AbstractAbstract PDFPubReaderePub
Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and skin biopsy revealed esophageal squamous cell carcinoma and paraneoplastic pemphigus. Palliative chemotherapy and systemic glucocorticoid were started, however, the patient died of overwhelming sepsis on the ninth day of chemotherapy. This case demonstrates that paraneoplastic pemphigus can occur in esophageal squamous cell carcinoma and could be a cause of morbidity.

Citations

Citations to this article as recorded by  
  • Paraneoplastic pemphigus: a rare case
    Thota Pravallika, K. V. T. Gopal, P. V. Krishnam Raju, B. Rekha Rani
    International Journal of Research in Dermatology.2025; 11(3): 280.     CrossRef
  • Paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome: Part I. Clinical overview and pathophysiology
    Hannah J. Anderson, Simo Huang, Jason B. Lee
    Journal of the American Academy of Dermatology.2024; 91(1): 1.     CrossRef
  • T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen
    Hayato Takahashi, Hisato Iriki, Yasuhiko Asahina
    The Journal of Dermatology.2023; 50(2): 112.     CrossRef
  • S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)
    Emiliano Antiga, Rikke Bech, Roberto Maglie, Giovanni Genovese, Luca Borradori, Barbara Bockle, Marzia Caproni, Frédéric Caux, Nisha Suyien Chandran, Alberto Corrà, Francesco D'Amore, Maryam Daneshpazhooh, Dipankar De, Dario Didona, Marian Dmochowski, Kos
    Journal of the European Academy of Dermatology and Venereology.2023; 37(6): 1118.     CrossRef
  • A Case of Severe Refractory Pemphigus Vulgaris in a Patient With Stable Esophageal Malignancy
    Vanessa C Browne, Catherine Choi, Eugenio M Capitle, Reena Khianey
    Cureus.2021;[Epub]     CrossRef
  • Paraneoplastic pemphigus and cutaneous squamous cell carcinoma: uncommun 3 cases
    Afaf Khouna
    Journal of Dermatology & Cosmetology.2021; 5(1): 17.     CrossRef
  • Pemphigus Vulgaris and Bullous Pemphigoid of the Upper Aerodigestive Tract: A Review Article and Novel Approaches to Management
    Mohammed Hassan Hussain, Faiz Tanweer, Georgios Sakagiannis, Manish Mair, Sara Mahmood, Sithamparappillai Ashokkumar
    ORL.2021; 83(6): 395.     CrossRef
  • A rare association of paraneoplastic pemphigus with gastric signet cell ring carcinoma
    Anfisa Lepekhova, Olga Olisova, Natalia Teplyuk, Dmitrii Zolotenkov, Anastasiia Allenova
    Australasian Journal of Dermatology.2019;[Epub]     CrossRef
  • Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus
    Kyle T. Amber, Manuel Valdebran, Sergei A. Grando
    Autoimmunity Reviews.2018; 17(10): 1002.     CrossRef
  • Pemphigus
    Patricia Chirinos-Saldaña, Alejandro Navas, Arturo Ramírez-Miranda, María Carmen Jiménez-Martínez, Enrique O. Graue-Hernández
    Eye & Contact Lens: Science & Clinical Practice.2016; 42(2): 91.     CrossRef
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Interstitial Pneumonitis after Treatment with Pemetrexed for Non-small Cell Lung Cancer
Kyeong-Hyun Kim, Seo-Young Song, Kyu-Hyoung Lim, Seon-Sook Han, Se-Hyun Kim, Jun Hwi Cho, Chan Woo Park, Seoungkoo Lee, Hui-Young Lee
Cancer Res Treat. 2013;45(1):74-77.   Published online March 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.1.74
AbstractAbstract PDFPubReaderePub
Pemetrexed is approved as a first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC) with cisplatin and as a single agent for second-line treatment or for patients who show no disease progression after four cycles of platinum-based doublet induction chemotherapy as maintenance therapy. Pemetrexed has a modest toxicity profile and has not traditionally been regarded as a cause of interstitial pneumonitis. Here, we report on a rare case of pemetrexed-induced pneumonitis in a patient with NSCLC.

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  • Incidence and risk of drug-induced interstitial lung disease associated with anti-neoplastic drugs
    Il-Hyung Hwang, Seung Hyeun Lee, Hankil Lee
    Expert Opinion on Drug Safety.2025; : 1.     CrossRef
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    Ryota Otoshi, Akimasa Sekine, Eri Hagiwara, Koji Okudela, Takuma Katano, Naoto Aiko, Goshi Matama, Kohsuke Isomoto, Satoshi Ikeda, Tomohisa Baba, Shigeru Komatsu, Takashi Ogura
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    N. China-Pereira, S. Campainha, A. Furtado, S. Conde, A. Barroso
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    B. Adhikari, R. M. Dongol, D. Baral, Y. Hewett, B. K. Shah
    Acta Oncologica.2016; 55(4): 521.     CrossRef
  • Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells
    Ki-Eun Hwang, Young-Suk Kim, Jae-Wan Jung, Su-Jin Kwon, Do-Sim Park, Byong-Ki Cha, Seon-Hee Oh, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
    Oncotarget.2015; 6(30): 29482.     CrossRef
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    Vera Hirsh
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    Motoyasu Kato, Takehito Shukuya, Fumiyuki Takahashi, Keita Mori, Kentaro Suina, Tetsuhiko Asao, Ryota Kanemaru, Yuichiro Honma, Keiko Muraki, Koji Sugano, Rina Shibayama, Ryo Koyama, Naoko Shimada, Kazuhisa Takahashi
    BMC Cancer.2014;[Epub]     CrossRef
  • Enhanced apoptosis by pemetrexed and simvastatin in malignant mesothelioma and lung cancer cells by reactive oxygen species-dependent mitochondrial dysfunction and Bim induction
    KI-EUN HWANG, YOUNG-SUK KIM, YU-RI HWANG, SU-JIN KWON, DO-SIM PARK, BYONG-KI CHA, BYOUNG-RYUN KIM, KWON-HA YOON, EUN-TAIK JEONG, HAK-RYUL KIM
    International Journal of Oncology.2014; 45(4): 1769.     CrossRef
  • Pemetrexed

    Reactions Weekly.2013; 1460(1): 34.     CrossRef
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