Cancer Research and Treatment

Volume 38(1); February 2006

Review Article

Tissue Array Methods for High-throughput Clinicopathologic Research: Hye Seung Lee, Woo Ho Kim; Cancer Res Treat. 2006;38(1):1-6. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.1

Recent research in molecular biology has identified a significant number of novel markers, which may have diagnostic, prognostic and therapeutic significance. High-throughput tissue array method facilitates the validation of novel markers by enabling the simultaneous analysis of hundreds or thousands of tissue specimens. Tissue array slides can be analyzed using techniques such as immunohistochemistry and in situ hybridization. In this review, we give a brief overview of tissue array method and its application to high throughput clinicopathologic research.

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Distinctive Phenotypic and Microenvironmental Characteristics of Neuroendocrine Carcinoma and Adenocarcinoma Components in Gastric Mixed Adenoneuroendocrine Carcinoma
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Modern Pathology.2024; 37(10): 100568. CrossRef
Prognostic significance of CD8 and TCF1 double positive T cell subset in microsatellite unstable gastric cancer
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Scientific Reports.2024;[Epub] CrossRef
Immunoscore is a strong predictor of survival in the prognosis of stage II/III gastric cancer patients following 5-FU-based adjuvant chemotherapy
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Differential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer
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Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer
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Original Articles

Long Term Trends and the Future Gastric Cancer Mortality in Korea: 1983~2013: Yunhee Choi, Jin Gwack, Yeonju Kim, Jisuk Bae, Jae-Kwan Jun, Kwang-Pil Ko, Keun-Young Yoo; Cancer Res Treat. 2006;38(1):7-12. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.7; Correction in: Cancer Res Treat 2007;39(1):44

Abstract PDF PubReader ePub

Purpose

In spite of gastric cancer's decreasing incidence and mortality rates, it is still the most common cancer in Korea. In the present study, we examined the temporal trends of gastric cancer mortality during the past 20 years in Korea by using an age-period-cohort model, and we predicted the mortality rates for the next 10 years.

Materials and Methods

Data on the annual number of deaths due to gastric cancer and data on population statistics from 1984 to 2003 were obtained from the Korean National Statistical Office. A log-linear Poisson age-period-cohort model was used to estimate age, period and birth cohort effects. To project two periods (10 years) into the future, the new cohort values were estimated by performing linear regression that was applied to a chosen number of the most recent cohort values.

Results

The trends of gastric cancer mortality were predominantly explained by the cohort effect; the risk of gastric cancer death decreased since the 1919 birth cohort for both genders. The predicted, expected age-adjusted mortality rates per 100,000 for males and females are 45.72 and 23.75, respectively, during 2004~2008, and 34.62 and 17.93 respectively, during 2009~2013. During 2004~2008 and 2009~2013, the predicted numbers of deaths due to gastric cancer in males are 36,922 and 27,959, respectively, whereas those in females are 19,698 and 14,869, respectively.

Conclusions

Not only the mortality, but also the incidence of gastric cancer in Korea is expected to further decrease in both men and women if the trends of the past 20 years continue.

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Prognostic Factors for Advanced Gastric Cancer: Stage-stratified Analysis of Patients who Underwent Curative Resection: Joong-Min Park, Woo-Sang Ryu, Jong-Han Kim, Sung-Soo Park, Seung-Joo Kim, Chong-Suk Kim, Young-Jae Mok; Cancer Res Treat. 2006;38(1):13-18. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.13

Abstract PDF PubReader ePub

Purpose

Advanced gastric cancer patients have a poorer prognosis as compared to the patients with early gastric cancer. This study was conducted to define the prognostic factors for advanced gastric cancer.

Materials and Methods

606 patients with advanced gastric cancer who underwent curative gastric resection at our hospital were retrospectively examined. The patients were divided into two groups: group 1 was comprised of patients with a survival time <5 years, and group 2 patients had a survival time ≥5 years. We compared clinicopathological characteristics of the two groups by performing univariate and multivariate analysis. We also investigated the prognostic factors according to the stage.

Results

On univariate analysis, 7 factors (age, tumor size, Borrmann type, resection type, distal resection margin, depth of invasion and lymph node status) were found to be different, and multivariate analysis revealed that patient age, depth of invasion and lymph node metastasis were the only significantly differences between the two groups. On the other hand, age and the Borrmann type for stage I b patients, age and the number of retrieved lymph nodes for stage II patients, tumor size for stage III patients, and the type of resection for stage IV patients were found to be the independent prognostic factors.

Conclusion

The age of patients had prognostic value in the early stages of advanced gastric cancers such as stage I b or II. The number greater than 20 retrieved lymph nodes affected the survival, particularly for the patients with stage II disease, and the tumor size was a significant prognostic factor for patients with stage III disease. Therefore, physicians are advised to pay special attention to lymph node dissection for those patients with stage II or III disease.

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Prognostic and Clinical Significance of the Positive Lymph Node Ratio in Patients Undergoing Radical Resection for Gastric Cancer
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Increased ERCC Expression Correlates with Improved Outcome of Patients Treated with Cisplatin as an Adjuvant Therapy for Curatively Resected Gastric Cancer: Sun Kyung Baek, Si-Young Kim, Jae Jin Lee, Yoon Wha Kim, Hwi Joong Yoon, Kyung Sam Cho; Cancer Res Treat. 2006;38(1):19-24. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.19

Abstract PDF PubReader ePub

Purpose

It has been reported that the overexpression of the excision repair cross-complementing 1 (ERCC1) gene, which is essential for the repair of cisplatin (CDDP)-DNA adducts, negatively influences the effectiveness of CDDP-based therapy for primary gastric cancer. We investigated whether the ERCC1 expression was associated with survival for gastric cancer patients in an adjuvant setting.

Materials and Methods

We retrospectively analyzed 44 patients who were diagnosed with stage II or higher disease after undergoing curative resection and they had also received cisplatin-based chemotherapy. The ERCC1 expression was examined by performing immunohistochemical (IHC) staining, and this was divided into two groups according to the percentage of IHC staining of the tumor cell nuclei (negative: 10% or less, positive: more than 10%).

Results

Among the 44 patients (ERCC1-negative/ERCC1-positive group=16/28), 32 patients were male and their median age was 52 years. There was no difference for the baseline characteristics of the two groups. The median follow-up duration was 41 months. The median disease-free survival (DFS) and the overall survival (OS) for the ERCC1-positive group were significant higher than those of the ERCC1-negative group (DFS: 40.4 vs. 14.6 months, p=0.02, OS: undefined vs. 20.4 months, p=0.008).

Conclusion

The overall survival in gastric cancer patients who received cisplatin-based adjuvant chemotherapy after a curative resection is higher in those patients showing the overexpression of the ERCC1 gene. However, prospective studies using the ERCC1 gene expression as a prognostic marker for the DNA repair activity are needed.

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Annals of Surgical Oncology.2012; 19(7): 2081. CrossRef
Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy
Ki Han Kim, Hyuk-Chan Kwon, Sung Yong Oh, Sung Hyun Kim, Suee Lee, Kyung A Kwon, Jin Seok Jang, Min Chan Kim, Su-Jin Kim, Hyo-Jin Kim
Biomarkers.2011; 16(1): 74. CrossRef
ERCC1: Impact in Multimodality Treatment of Upper Gastrointestinal Cancer
Ralf Metzger, Elfriede Bollschweiler, Arnulf H Hölscher, Ute Warnecke-Eberz
Future Oncology.2010; 6(11): 1735. CrossRef
Biomarker analysis in stage III–IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival
J-S Kim, M-A Kim, T M Kim, S-H Lee, D-W Kim, S-A Im, T-Y Kim, W H Kim, H-K Yang, D S Heo, Y-J Bang, K-U Lee, K-J Choe, N K Kim
British Journal of Cancer.2009; 100(5): 732. CrossRef

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Characteristics of Synchronous Cancers in Gastric Cancer Patients: Ja Seong Bae, Jun Ho Lee, Keun Won Ryu, Young Woo Kim, Jae Moon Bae; Cancer Res Treat. 2006;38(1):25-29. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.25

Abstract PDF PubReader ePub

Purpose

The primary objective of the current study was to investigate the characteristics of synchronous cancers in gastric cancer patients.

Materials and Methods

We analyzed the 2,237 patients who were diagnosed between December 2000 and December 2003 with gastric cancer and synchronous cancers of organs other than the stomach.

Results

73 (3.3%) of a total of 2,237 gastric cancer patients had synchronous primary cancers. Among these 73 patients, 71 had one synchronous cancer, and two patients had double synchronous cancers. Colorectal cancer (26 patients, 34.7%) was the most frequently encountered synchronous cancer, followed by cancer of the lung (16 patients, 21.3%), esophagus (13 patients, 17.2%), and liver (8 patients, 10.7%). Synchronous cancers were detected with increased frequency in the elderly, in the patients with multiple gastric cancers, in the patients with differentiated gastric cancer, and in the patients with early gastric cancer, as determined on univariate analysis, but the differentiation of gastric cancers was the only risk factor for synchronous cancers on the multivariate analysis.

Conclusions

The differentiation of gastric cancer cells may be a risk factor for synchronous cancers in gastric cancer patients. Careful surveillance by the physician for synchronous cancer is warranted for the patients suffering from gastric cancer.

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Synchronous Gastric and Colonic Adenocarcinoma: A Case Report With its Molecular Implications
Lakshmipriya V, Sarah Grace Priyadarshini , Neha Agarwal, Padmapriya B S
Cureus.2024;[Epub] CrossRef
Triple metachronous primary cancer of uterus, colon, and breast cancer
Guanqiao Li, Jia Yao, Tangna Wu, Yaxiong Chen, Zhenping Wang, Yiming Wang, Fen Wang, Rui Zhong, Shiping Yang
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Gastric cancer and intrahepatic cholangiocarcinoma
Alex Emmanuel Elobu, Ashok Thorat, Vianney Kweyamba, Rakesh Rai
Formosan Journal of Surgery.2019; 52(3): 107. CrossRef
Clinicopathologic characteristics and survival rate in patients with synchronous or metachronous double primary colorectal and gastric cancer
Ji-Hyeon Park, Jeong-Heum Baek, Jun-Young Yang, Won-Suk Lee, Woon-Kee Lee
Korean Journal of Clinical Oncology.2018; 14(2): 83. CrossRef
Can positron emission tomography detect colorectal adenomas and cancers?
Kimihiro Igarashi, Kinichi Hotta, Kenichiro Imai, Yuichiro Yamaguchi, Sayo Ito, Noboru Kawata, Masaki Tanaka, Naomi Kakushima, Kohei Takizawa, Hiroyuki Matsubayashi, Masahiro Endo, Kouiku Asakura, Takuma Oishi, Tadakazu Shimoda, Hiroyuki Ono
Journal of Gastroenterology and Hepatology.2017; 32(3): 602. CrossRef
Triple synchronous primary malignancies: a rare occurrence
Heather Katz, Hassaan Jafri, Linda Brown, Toni Pacioles
BMJ Case Reports.2017; 2017: bcr-2017-219237. CrossRef
A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine Cell Carcinoma in the Stomach
Ji-Hoon Kim, Dae-Woon Eom, Cheon-Soo Park, Jae-Young Kwak, Eun-Hwa Park, Jin-Ho Kwak, Hyuk-Jae Jang, Kun-Moo Choi, Myung-Sik Han
Journal of Gastric Cancer.2016; 16(4): 266. CrossRef
Synchronous triple primary cancers occurring in the stomach, kidney, and thyroid
Sung Jin Oh, Dong Sik Bae, Byoung Jo Suh
Annals of Surgical Treatment and Research.2015; 88(6): 345. CrossRef
Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer
I. Cho, J.Y. An, I.G. Kwon, Y.Y. Choi, J.H. Cheong, W.J. Hyung, S.H. Noh
European Journal of Surgical Oncology (EJSO).2014; 40(3): 338. CrossRef
Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
Journal of Gastric Cancer.2014; 14(3): 211. CrossRef
Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
Journal of Gastric Cancer.2014; 14(3): 211. CrossRef
Management of gastric epithelial neoplasia in patients requiring esophagectomy for esophageal cancer
H. I., G. H. Kim, D. Y. Park, Y. D. Kim, B. E. Lee, D. Y. Ryu, D. U. Kim, G. A. Song
Diseases of the Esophagus.2013; 26(6): 603. CrossRef
Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: a case report
Takashi Sato, Koji Tomaru, Tomoko Koide, Makoto Masuda, Masaki Yamamoto, Naoki Miyazawa, Yoshiaki Inayama, Takeshi Kaneko, Yoshiaki Ishigatsubo
Journal of Medical Case Reports.2012;[Epub] CrossRef
Synchronous primary gastric cancer and renal cell carcinoma: A case report and literatures review
Kung-Ning Hu, Wei-Hong Lai, Po-Tsang Tseng, Wen-Ching Wang, Kun-Hung Shen
Urological Science.2012; 23(1): 28. CrossRef
Synchronous multifocal early gastric cancers and rectal adenocarcinoma: Lesson learnt from image‐enhanced endoscopy
Boon Eu Andrew KWEK, Tiing Leong ANG, Kwong Ming FOCK, Eng Kiong TEO
Journal of Digestive Diseases.2011; 12(3): 226. CrossRef
Clinical improvement of membranous nephropathy after endoscopic resection of double early gastrointestinal cancers
Satoshi Matsui, Hiroko Tsuji, Yukinobu Takimoto, Shinji Ono
Clinical and Experimental Nephrology.2011; 15(2): 285. CrossRef
Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients
Shin Hyuk Kim, Byung Kyu Ahn, Young Su Nam, Joo Youn Pyo, Young Ha Oh, Kang Hong Lee
Journal of Gastric Cancer.2010; 10(4): 149. CrossRef
Second primary cancers in patients with gastric cancer
Oktay Buyukasik, Ahmet Hasdemir, Yusuf Gulnerman, Cavit Col, Ozgur Ikiz
Radiology and Oncology.2010;[Epub] CrossRef

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Optimal Timing for the Administration of Capecitabine with Preoperative Chemoradiation for Locally Advanced Rectal Cancer: Young Ju Noh, Won Sik Choi, Jong Hoon Kim, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Tae Won Kim, Heung Moon Chang, Min Hee Ryu, Seung Do Ahn, Sang-wook Lee, Seong Soo Shin, Jung Eun Lee, Eun Kyung Choi; Cancer Res Treat. 2006;38(1):30-34. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.30

Abstract PDF PubReader ePub

Purpose

Capecitabine is an oral fluoropyrimidine carbamate and it is known as an effective radiosensitizer. Capecitabine and its metabolite reach their peak concentration in the plasma at 1~2 hours after a single oral administration of capecitabine and the levels fall rapidly thereafter. To verify the radiosensitizing effect of capecitabine that is based on such pharmacokinetic characteristics, we performed a retrospective analysis on the optimal timing of capecitabine administration with performing preoperative chemoradiation for locally advanced rectal cancer.

Materials and Methods

Among 171 patients who were treated with preoperative radiotherapy and concurrent capecitabine administration for rectal cancer, 56 patients were administered capecitabine at 1~2 hours before radiotherapy (group A), and at other time in the other 115 patients (group B). Total mesorectal excision was done at 4 to 6 weeks after the completion of chemoradiation. The radiosensitizing effect of capecitabine was evaluated on the basis of the pathological response.

Results

Complete pathological regression of the primary tumor was observed in 12 patients (21.4%) for group A and in 11 patients (9.6%) for group B (p=0.031). Residual disease less than 0.5 cm (a good response) was observed in 19 patients (33.9%) for group A and in 23 patients (20.0%) for group B (p=0.038). On multivariate analysis, the capecitabine ingestion time showed marginal significance.

Conclusion

When performing preoperative chemoradiation for locally advanced rectal cancer, the radiosensitizing effect of capecitabine was enhanced when it was administered 1 hour before radiotherapy.

Citations

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Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer
R Clifford, N Govindarajah, J L Parsons, S Gollins, N P West, D Vimalachandran
British Journal of Surgery.2018; 105(12): 1553. CrossRef

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Serum HER2 as a Response Indicator to Various Chemotherapeutic Agents in Tissue HER2 Positive Metastatic Breast Cancer: Sun-Young Kong, Do Hoon Lee, Eun Sook Lee, Susan Park, Keun Seok Lee, Jungsil Ro; Cancer Res Treat. 2006;38(1):35-39. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.35

Abstract PDF PubReader ePub

Purpose

The aim of study was to evaluate the usefulness of serum HER2 as a therapeutic response indicator in patients with HER2 positive metastatic breast cancer (MBC).

Materials and Methods

The levels of serum HER2 and CA15.3 were assayed in 148 serial serum samples from 50 HER2 positive MBC patients at both the baseline and follow-ups. The changes in the levels of serum HER2 and CA15.3 in relation to the tumor responses to the various chemotherapy regimens were monitored.

Results

The levels of serum HER2 and CA15.3 were elevated in 82% and 62% of tissue HER2 positive patients, respectively, prior to therapies, with the changes in both tumor markers showing statistical significance in relation to the tumor responses (p<0.01) in patients with elevated baseline serum markers.

Conclusion

The level of serum HER2 could be a valuable response indicator, not only for trastuzumab containing therapy, but also for other common MBC chemotherapeutic agents. Also, as it is more frequently elevated, the serum level of HER2 may also be a more useful tumor marker than CA15.3 in HER2 positive MBC.

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AlGaN/GaN HEMT Based Biosensor for Detection of the HER2 Antigen Spiked in Human Serum
Shivanshu Mishra, Pharyanshu Kachhawa, Prasenjit Mondal, Surajit Ghosh, Chaturvedula Tripura, Nidhi Chaturvedi
IEEE Transactions on Electron Devices.2022; 69(8): 4527. CrossRef
Amphiregulin confers trastuzumab resistance via AKT and ERK activation in HER2-positive breast cancer
Ji-Won Kim, Debora K. Kim, Ahrum Min, Kyung-Hun Lee, Hyun-Jin Nam, Jee Hyun Kim, Jin-Soo Kim, Tae-Yong Kim, Seock-Ah Im, In Ae Park
Journal of Cancer Research and Clinical Oncology.2016; 142(1): 157. CrossRef
The Significance of Serum HER2 Levels at Diagnosis on Intrinsic Subtype-Specific Outcome of Operable Breast Cancer Patients
Moo Hyun Lee, So-Youn Jung, Sun Hee Kang, Eun Jin Song, In Hae Park, Sun-Young Kong, Young Mee Kwon, Keun Seok Lee, Han-Sung Kang, Eun Sook Lee, Aamir Ahmad
PLOS ONE.2016; 11(10): e0163370. CrossRef
HER2 amplification level is not a prognostic factor for HER2-positive breast cancer with trastuzumab-based adjuvant treatment: a systematic review and meta-analysis
Qian-Qian Xu, Bo Pan, Chang-Jun Wang, Yi-Dong Zhou, Feng Mao, Yan Lin, Jing-Hong Guan, Song-Jie Shen, Xiao-Hui Zhang, Ya-Li Xu, Ying Zhong, Xue-Jing Wang, Yan-Na Zhang, Qiang Sun
Oncotarget.2016; 7(39): 63571. CrossRef
Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status
Maria Soares, Rita Ribeiro, Shabir Najmudin, Andreia Gameiro, Rita Rodrigues, Fátima Cardoso, Fernando Ferreira
Oncotarget.2016; 7(14): 17314. CrossRef
A comparative study of disease genes and drug targets in the human protein interactome
Jingchun Sun, Kevin Zhu, W Jim Zheng, Hua Xu
BMC Bioinformatics.2015;[Epub] CrossRef
Classification of Cancer Primary Sites Using Machine Learning and Somatic Mutations
Yukun Chen, Jingchun Sun, Liang-Chin Huang, Hua Xu, Zhongming Zhao
BioMed Research International.2015; 2015: 1. CrossRef
HER2/CEP17 ratio and HER2 immunohistochemistry predict clinical outcome after first-line trastuzumab plus taxane chemotherapy in patients with HER2 fluorescence in situ hybridization-positive metastatic breast cancer
Ji-Won Kim, Jee Hyun Kim, Seock-Ah Im, Yu Jung Kim, Hye-Suk Han, Jin-Soo Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Yoon Kyung Jeon, Do-Youn Oh, Tae-You Kim, In Ae Park
Cancer Chemotherapy and Pharmacology.2013; 72(1): 109. CrossRef
Serum epidermal growth factor is associated with prognosis and hormone receptor status in patients with HER2-positive metastatic breast cancer treated with first-line trastuzumab plus taxane chemotherapy
Ji-Won Kim, Jee Hyun Kim, Seock-Ah Im, Kyung-Hun Lee, Jin-Soo Kim, Tae-Yong Kim, Sae-Won Han, Yoon Kyung Jeon, Do-Youn Oh, Tae-You Kim, In Ae Park
Cancer Chemotherapy and Pharmacology.2013; 72(5): 1023. CrossRef
ABCB1, FCGR2A, and FCGR3A Polymorphisms in Patients with HER2-Positive Metastatic Breast Cancer Who Were Treated with First-Line Taxane plus Trastuzumab Chemotherapy
Ji-Won Kim, Jee Hyun Kim, Seock-Ah Im, Yu Jung Kim, Hye-Suk Han, Jin-Soo Kim, Sae-Won Han, Yoon Kyung Jeon, Do-Youn Oh, Wonshik Han, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang
Oncology.2012; 83(4): 218. CrossRef
In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models
Guodong Shen, Hui Huang, Anli Zhang, Ting Zhao, Siyi Hu, Liansheng Cheng, Jing Liu, Weihua Xiao, Bin Ling, Qiang Wu, Lihua Song, Wei Wei
Cancer Immunology, Immunotherapy.2011; 60(3): 339. CrossRef
Serum HER2 Level Measured by Dot Blot: A Valid and Inexpensive Assay for Monitoring Breast Cancer Progression
Li-Duan Tan, Yuan-Yuan Xu, Yue Yu, Xiao-Qing Li, Ying Chen, Yu-Mei Feng, Irina Lebedeva
PLoS ONE.2011; 6(4): e18764. CrossRef

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The Effect of Simulation on Recurrence after Breast-Conserving Surgery and Radiotherapy: Preliminary Results: Ji-Yoon Kim, Yeon-Sil Kim, Mi-Ryung Ryu, Sung-Whan Kim, Chul-Seung Kay, Sei-Chul Yoon, Woo-Chan Park, Byung-Joo Song, Se-Jeong Oh, Sang-Seol Jung, Jong-Man Won, Seung-Nam Kim, Su-Mi Chung; Cancer Res Treat. 2006;38(1):40-47. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.40

Abstract PDF PubReader ePub: Purpose
To evaluate the effect of the simulation method on recurrence among the patients who received radiotherapy after breast-conserving surgery (BCS) for early breast carcinoma.
Materials and Methods
Between 1995 and 2000, 70 patients with stage I-II breast carcinoma underwent breast-conserving surgery and adjuvant radiotherapy. Twenty nine patients (41.4%) were simulated with the 2D contour-based method (September 1995 to August 1997) and 41 patients (58.6%) were simulated with the 3D CT-based method (September 1997 to February 2000). To analyze the effect of the simulation method, the patient and treatment characteristics were compared.
Results
The characteristics were similar for the patients between the 2D contour-based simulation group and the 3D CT-based simulation group. During a median follow-up period of 75 months, 4 (13.8%) of 29 patients who were treated with 2D simulation and 1 (2.4%) of 41 patients who were treated with 3D simulation group developed treatment failure. The five-year survival rates were 89.2% and 95.1% between the 2D and 3D simulation groups (p=0.196). The five-year disease free survival (DFS) rates were 86.2% and 97.5% between the 2D and 3D simulation groups (p=0.0636). On univariate analysis, age > 40 (p= 0.0226) and the number of dissected axillary lymph node ≥ 10 (p=0.0435) were independent predictors of improved 5-year DFS.
Conclusions
Although our data showed marginal significance for the DFS between the two groups, it is insufficient, due to the small number of patients in our study, to prove whether 3D CT-based simulation might improve the DFS and reduce the risk of recurrence when compared with 2D contour-based simulation. Further study is needed with a larger group of patients.

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Resveratrol at High Doses Acts as an Apoptotic Inducer in Endothelial Cells: Kyungmin In, Jongbong Park, Heonyong Park; Cancer Res Treat. 2006;38(1):48-53. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.48

Abstract PDF PubReader ePub

Purposes

Resveratrol is a phenolic compound found in grapes and other food products. In order to assess the availability of resveratrol as an angio-inhibiting drug, we examined whether resveratrol plays an important role in bovine aortic endothelial cells (BAECs) for cell apoptosis and cell migration.

Methods and Materials

Endothelial cell apoptosis was observed as detected by the Hoechst staining and the caspase-3 activity. Additionally, Western blotting was performed for monitoring the activities of various cell signaling molecules.

Results

Resveratrol was shown to act as a pro-apoptotic agent. The pro-apoptotic effect of resveratrol was as great as that of etoposide, a well-known anti-cancer drug. In addition, resveratrol had an inhibitory effect on endothelial cell migration. The demonstrated efficacy of resveratrol suggests that resveratrol may be utilized as an anti-angiogenic drug. To determine the underlying mechanisms, we further investigated which signaling molecules are activated by resveratrol. Extracellular signal-regulated kinase (ERK) was activated by the treatment with resveratrol in BAECs, whereas endothelial nitric oxide synthetase (eNOS), Akt, and Jun N-terminal kinase (JNK) were inhibited. The pretreatment with PD compound, an ERK inhibitor, had no effect on the pro-apoptosis induced by resveratrol.

Conclusion

Resveratrol plays an important role in endothelial cell apoptosis, indicating that resveratrol can be utilized as a potent anti-angiogenic drug.

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Novel plasma-polymerized coating facilitates HeLa cell spheroid formation, exerting necroptosis via β-cyclodextrin-encapsulated resveratrol
Sujeong Jang, Namwuk Baek, Youngsik Seo, Hyuna Lim, Donggeun Jung, Heonyong Park
Journal of Analytical Science and Technology.2024;[Epub] CrossRef
Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol
Lijing Zhang, Kaining Zhi, Yanfang Su, Wenpeng Peng, Xianfang Meng
Molecular Neurobiology.2023; 60(10): 6043. CrossRef
A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity
Bryce LaFoya, Jordan A. Munroe, Allan R. Albig, Myon-Hee Lee
PLOS ONE.2019; 14(1): e0210607. CrossRef
Resveratrol-Induced Temporal Variation in the Mechanical Properties of MCF-7 Breast Cancer Cells Investigated by Atomic Force Microscopy
Jagoba Iturri, Andreas Weber, Alberto Moreno-Cencerrado, Maria dM Vivanco, Rafael Benítez, Stefano Leporatti, José Luis Toca-Herrera
International Journal of Molecular Sciences.2019; 20(13): 3275. CrossRef
Effect of Fermented Platycodon grandiflorum Extract on Cell Proliferation and Migration in Bovine Aortic Endothelial Cells
Woosoung Choi, Jina Song, Mi-Hyeon Park, Heui Jong Yu, Heonyong Park
Journal of Life Science.2016; 26(1): 59. CrossRef
Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells
RUBICELI MEDINA-AGUILAR, LAURENCE A. MARCHAT, ELENA ARECHAGA OCAMPO, PATRICIO GARIGLIO, JAIME GARCÍA MENA, NICOLÁS VILLEGAS SEPÚLVEDA, MACARIO MARTÍNEZ CASTILLO, CÉSAR LÓPEZ-CAMARILLO
Oncology Reports.2016; 35(6): 3696. CrossRef
Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells
Tomohiko Fukuda, Katsutoshi Oda, Osamu Wada-Hiraike, Kenbun Sone, Kanako Inaba, Yuji Ikeda, Chinami Makii, Aki Miyasaka, Tomoko Kashiyama, Michihiro Tanikawa, Takahide Arimoto, Tetsu Yano, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
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Apoptotic Effect of Pinosylvin at a High Concentration Regulated by c-Jun N-Terminal Kinase in Bovine Aortic Endothelial Cells
Jina Song, Jinsun Park, Eunsil Jeong, A-Young So, Jaeho Pyee, Heonyong Park
Journal of Life Science.2015; 25(4): 416. CrossRef
Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis
Jiening Dun, Xueyan Chen, Haixia Gao, Yan Zhang, Huajun Zhang, Yongjian Zhang
Experimental Biology and Medicine.2015; 240(12): 1672. CrossRef
Pinosylvin at a high concentration induces AMPK-mediated autophagy for preventing necrosis in bovine aortic endothelial cells
Jinsun Park, Jaeho Pyee, Heonyong Park
Canadian Journal of Physiology and Pharmacology.2014; 92(12): 993. CrossRef
Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-α-dependent pathway
Arif Yurdagul, James J. Kleinedler, Marshall C. McInnis, Alok R. Khandelwal, Allyson L. Spence, A. Wayne Orr, Tammy R. Dugas
American Journal of Physiology-Heart and Circulatory Physiology.2014; 306(6): H797. CrossRef
Protective Effects of Resveratrol on TNF-α-Induced Endothelial Cytotoxicity in Baboon Femoral Arterial Endothelial Cells
Juan Xiao, Jun Song, Vida Hodara, Allen Ford, Xing Li Wang, Qiang Shi, Li Chen, John L. VandeBerg
Journal of Diabetes Research.2013; 2013: 1. CrossRef
Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines
Fatemehsadat Amiri, Amir-Hassan Zarnani, Hamid Zand, Fariba Koohdani, Mahmood Jeddi-Tehrani, Mohammadreza Vafa
European Journal of Pharmacology.2013; 718(1-3): 34. CrossRef
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova-Kostova, Ivo Iavicoli, Rosanna Di Paola, Aleardo Koverech, Salvatore Cuzzocrea, Enrico Rizzarelli, Edward J. Calabrese
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2012; 1822(5): 753. CrossRef
Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats
Yavuz Simsek, Simay Gurocak, Yusuf Turkoz, Nusret Akpolat, Onder Celik, Ali Ozer, Ercan Yılmaz, Ugur Turhan, Fatma Ozyalin
Journal of Pediatric and Adolescent Gynecology.2012; 25(4): 262. CrossRef
Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development
Lindsay Peltz, Jessica Gomez, Maribel Marquez, Frances Alencastro, Negar Atashpanjeh, Tara Quang, Thuy Bach, Yuanxiang Zhao, Antonio Paolo Beltrami
PLoS ONE.2012; 7(5): e37162. CrossRef
Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells
Minna Kairisalo, Alessandra Bonomo, Alise Hyrskyluoto, Giuseppa Mudò, Natale Belluardo, Laura Korhonen, Dan Lindholm
Neuroscience Letters.2011; 488(3): 263. CrossRef
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Christoph A. Schmitt, Elke H. Heiss, Verena M. Dirsch
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Dose-Dependency of Resveratrol in Providing Health Benefits
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Resveratrol commonly displays hormesis: Occurrence and biomedical significance
Edward J Calabrese, Mark P Mattson, Vittorio Calabrese
Human & Experimental Toxicology.2010; 29(12): 980. CrossRef
Biochemical characterization of the lipid-binding properties of a broccoli cuticular wax-associated protein, WAX9D, and its application
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Arsenic Trioxide Induces Apoptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS: Young Cha, Dae-Weon Park, Chu Hee Lee, Suk-Hwan Baek, Seong-Yong Kim, Jae-Ryong Kim, Jung Hye Kim; Cancer Res Treat. 2006;38(1):54-60. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.54

Abstract PDF PubReader ePub

Purpose

Treatment with arsenic trioxide (As₂O₃) results in a wide range of cellular effects that includes induction of apoptosis, inhibition of cell growth, promotion or inhibition of cellular differentiation, and inhibition of angiogenesis through a variety of mechanisms. The mechanisms of As₂O₃-induced cell death have been mainly studied in hematological cancers, and those mechanisms in solid cancers have yet to be clearly defined. In this study, the mechanisms by which As₂O₃ induces apoptosis in human colorectal adenocarcinoma HT-29 cells were investigated.

Materials and Methods

To examine the levels of apoptosis, HT-29 cells were treated with As₂O₃ and then we measured the percentage of Annexin V binding cells, the amount of ROS production and the mitochondrial membrane potential. Western blot analysis was performed to identify the activated caspases after As₂O₃ exposure, and we compared the possible target molecules of apoptosis. As₂O₃ treatment induced the loss of the mitochondrial membrane potential and an increase of ROS, as well as activation of caspase-3, -7, -9 and -10.

Results

As₂O₃ induced apoptosis via the production of reactive oxygen species and the loss of the mitochondrial membrane potential. As₂O₃ induced the activation of caspase-3, -7, -9 and -10. Furthermore, As₂O₃ treatment downregulates the Mcl-1 and Bcl-2 expressions, and the release of cytochrome c and an apoptosis-inducing factor (AIF). Pretreating the HT-29 cells with N-acetyl-L-cysteine, which is a thiol-containing antioxidant, inhibited the As₂O₃-induced apoptosis and caspase activation.

Conclusion

Taken together, these results suggest that the generation of reactive oxygen species (ROS) by As₂O₃ might play an important role in the regulation of As₂O₃-induced apoptosis. This cytotoxicity is mediated through a mitochondria-dependent apoptotic signal pathway in HT-29 cells.

Citations

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Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date
Meng Yan, Hao Wang, Rui Wei, Wenwen Li
Archives of Pharmacal Research.2024; 47(3): 249. CrossRef
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